Canadian Asset Map for Stem Cell

Canadian asset Map for steM Cell and regenerative MediCine This publication is also available online in HTML and .pdf formats at www.ic.gc.ca/stemcells This publication is available upon request in accessible formats. Contact: Multimedia Services Section Communications and Marketing Branch Industry Canada Room 441E, East Tower 235 Queen Street Ottawa ON K1A 0H5 Telephone: 613-995-8552 Fax: 613-954-6436 Email: [email protected] Aussi offert en français sous le titre : Carte des ressources canadiennes dans les domaines des cellules souches et de la médecine régénérative Cette publication est disponible en ligne en formats HTML et pdf à www.ic.gc.ca/cellulessouches Release Note: Published by Industry Canada, March 2012. To obtain an electronic copy of this report, please visit www.ic.gc.ca/stemcells perMission to reproduCe: Non-commercial Reproduction Except as otherwise specifically noted, the information in this publication may be reproduced, in part or in whole and by any means, without change or further permission for non-commercial re-distribution, provided that due diligence is exercised in ensuring the accuracy of the information reproduced; that International BioPharma Solutions Ltd. is identified as the source; and that the reproduction is not represented as an official version of the information reproduced, nor as having been made in affiliation with, or with the endorsement of Industry Canada or International BioPharma Solutions Ltd. Commercial Reproduction Reproduction of materials in this document, in whole or in part, for the purposes of commercial redistribution is prohibited except with written permission from International BioPharma Solutions Ltd. For permission to reproduce the information in this publication for commercial redistribution, please contact : International BioPharma Solutions Ltd. 1277 Nelson Street, Suite 1502 Vancouver, BC, V6E 4M8 Canada Telephone: 604-408-4310 Fax: 604-408-4312 Internet: www.BioPharmaSolutions.com disClaiMer: This report was produced by International BioPharma Solutions Ltd. under contract for Industry Canada. The contents of the report are those of the report’s author, International BioPharma Solutions Ltd., and do not necessarily reflect the views of Industry Canada or the Government of Canada. note to readers: This study was completed in March 2011, and the majority of the research was conducted between December 2010 and January 2011. The data and information contained in this report are believed to be reliable and accurate as of December 2010 to January 2011 but are not guaranteed for completeness or accuracy. Design and Pre-press production by: AN Design Communications Ottawa, ON www.an-design.ca TABLE OF CONTENTS3

1 EXECUTIVE SUMMARY 2

2 INTRODUCTION 4 2.1 Importance of Regenerative Medicine and Stem Cells 4 2.2 Purpose of the Asset Map 4 2.3 Description of Stem Cells 5

3 OVERVIEW OF STEM CELL AND REGENERATIVE MEDICINE RESEARCH IN CANADA 7 3.1 Canada’s Global Position in Stem Cell and Regenerative Medicine Research 7 3.2 Funding for Stem Cell and Regenerative Medicine Research 8 3.3 Stem Cell and Regenerative Medicine Research Centres 9 3.4 Funding and Researchers by University and Province 9

4 FOCUS OF STEM CELL AND TISSUE ENGINEERING RESEARCHERS 13 4.1 Pluripotent Stem Cells 13 4.2 Tissue-Specific Stem Cells (Somatic) 14 4.3 Cancer Stem Cells 15 4.4 Tissue Engineering 15

5 DISEASES/CONDITIONS TARGETED BY STEM CELL AND REGENERATIVE MEDICINE RESEARCHERS 19 5.1 Cancer 19 5.2 Neurology 19 5.3 Musculoskeletal 20 5.4 Cardiovascular 20 5.5 Metabolic Including Diabetes 20 5.6 Hematological 21 5.7 Other 21 5.8 Translational Medicine 21

6 RELEVANT SUPPORT FACILITIES 25 6.1 Biobanks 25 6.2 Other Relevant Facilities 25

7 NETWORKS 31 7.1 National and International Networks 31 7.2 Provincial Networks 31

8 KEY RESEARCHERS AND INSTITUTIONS 37 8.1 Key Researchers 37 8.2 Key Research Institutions 39

9 CONCLUSION 46

10 ACKNOWLEDGEMENTS 46

11 CONTACTS 47

iii CANADIAN ASSET MAP FOR STEM CELL TABLEAND REGENERATIVE OF CONTENTS MEDICINE

appendiX 48 Appendix 1 Methodology 48 Appendix 2 Interviewees 51 Appendix 3 Lists of Canadian Stem Cells and Regenerative Medicine Researchers 52 3a. Researchers in Alphabetical Order 52 3b. Researchers According to Regenerative Medicine Focus 96 3c. Researchers According to Disease Focus 117 3d. Examples of Researchers Working in Translational Medicine and/or Clinical Trials 135 Appendix 4 Research Centres Listed by Province 137 Appendix 5 References and Notes 141

iv Canadian asset Map for steM Cell and regenerative MediCine Prepared by International BioPharma Solutions Ltd. For the Life Science Industries Branch of Industry Canada CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE

eXeCutive suMMarY

• Regenerative medicine, particularly stem (9% each) cells, has considerable potential to help in • 416 researchers (in professor, associate the treatment of numerous common and professor, or similar positions) were intractable diseases and conditions identifi ed as working in the fi eld of stem • Canada is a leader in stem cell research cells and regenerative medicine research; as these cells were fi rst discovered by 47% of these are located in Ontario, 25% Canadian scientists; however, other in Quebec, 13% in British Columbia and countries have become more and more 9% in Alberta important in this fi eld • In terms of universities, the University • 68 centres within or affi liated with 25 of Toronto (or its affi liated institutions) of Canada’s universities are associated houses by far the greatest number of with stem cell and regenerative medicine researchers (26%), followed by the research University of British Columbia (UBC) • From the sources available for this Asset (12%), the University of Ottawa, McGill Map (mainly federal government), University, and Université de Montréal more than $277.5 million was spent on • Many of the 416 researchers are stem cell and regenerative medicine extremely well regarded, with 81 research over the last fi ve years (2006/7– endowed Chairholders, 69 of whom 2010/11), with Canadian Institutes of are Canada Research Chairs (CRCs); Health Research (CIHR) and Canada 20 researchers have made signifi cant Foundation for Innovation (CFI) as the contributions to stem cell research and/or largest funders (providing 36% and 23% are particularly well funded and/or cited of funds, respectively); since the data • Th e most important research from these sources perhaps account organizations within or affi liated with for only 50%–60% of overall funding, the universities in terms of numbers approximately $460 million–$560 million of stem cell and regenerative medicine were probably spent on stem cell/ researchers and endowed Chairs are regenerative medicine research with the University of Toronto (Ontario • Th e majority (65%) of funding went to Cancer Institute, Sick Kids, McEwen Ontario (ON), particularly the University Centre, Sunnybrook), the University of of Toronto and the University of Ottawa; British Columbia (Terry Fox Laboratory), Québec (QC) received 15%, followed by Université Laval (Laboratoire British Columbia (BC) and Alberta (AB) d’organogénèse expérimentale—LOEX),

2 EXECUTIVE SUMMARY 1

and the University of Ottawa (Sprott • Canada has at least 4 public or university Centre) cord blood banks, 2 stem cell line banks, • 73% of researchers work with stem and 15 other relevant tissue banks that cells of some type, while 19% work in can be accessed by its regenerative tissue engineering; others work in social medicine researchers; it also has at least sciences & humanities, bioprocessing, 3 stem cell bioprocessing/manufacturing or various stem cell technologies such facilities as well as other relevant shared as high throughput sorting/analysis or infrastructure cryopreservation • Canada’s stem cell and regenerative • Within the stem cell research area, 54% of medicine researchers are members of researchers work with tissue-specifi c stem at least 5 international, 6 national, and cells, 16% with pluripotent stem cells and numerous provincial relevant networks 10% with cancer stem cells; another 10% • Overall, Canada remains among the work with a number of stem cell types, world leaders in stem cell research. with the majority working with both tissue-specifi c and pluripotent • Of the researchers who only work with tissue-specifi c stem cells, 36% work with hematopoietic, 19% with bone marrow/ mesenchymal and 14% with neural cells • Of those who work with pluripotent stem cells, 92% work with embryonic and 20% with induced pluripotent stem cells (some researchers work with both types of pluripotent stem cells) • Within the tissue engineering fi eld, at least 65% work with both scaﬀ olds and cells, while 27% work just with biomaterials; the focus of the other researchers was unspecifi ed • In terms of disease focus, 25% work in two or more disease areas, 24% work just on cancer, and 14% on neurological, 12% on musculoskeletal, and 10% on cardiovascular conditions • Perhaps 100 researchers (24%) are involved in the translation of stem cell research from the laboratory to the clinic, with the Stem Cell Network (SCN) so far devoting approximately $50 million to the funding of translational projects over the past 10 years

3 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE

introduCtion

2.1 Importance of Regenerative in wound healing. However, these clinical Medicine and Stem Cell uses represent just a small fraction of the Regenerative medicine involves the renewal opportunities in regenerative medicine of body tissues or the restoration of organ and researchers are working furiously to and tissue function through the use of understand the role stem cells may play living cells, particularly stem cells. Stem in other diseases, and to translate these cells off er a particularly rich source of findings into the clinic. regenerative technologies as, under the right conditions, they can diff erentiate To be clinically effective, stem cells need into many diff erent cell types (see below). to be delivered to and integrate with the Th ey have considerable potential to help relevant body site. Delivery methods can in the treatment of numerous common include gels, films, scaffolds, and targeted and intractable diseases and conditions, carrier technologies that are produced such as diabetes, arthritis, stroke, renal from biomaterials (e.g., polymers, lipids), failure, heart failure, cancer, spinal cord modified cells or, in the case of some injury, and neurodegenerative diseases, carrier technologies, modified viruses. including Parkinson’s and Alzheimer’s. Th ey The combination of stem cells (or other can also be used in organ regeneration, cell types) and a scaffold or similar genetic diseases, and other tissue repair technology is called tissue engineering. or replacement (e.g., bone and skin Furthermore, because stem cells occur in transplants, cartilage regeneration). highly limited quantities within the body, effective methods are required to mobilize, A number of stem cell-based regenerative isolate, culture, and store them. Adequate technologies are used today, such as production methods are essential to eye surface stem cells for the treatment unlocking their clinical potential. of some corneal diseases and injuries; and blood stem cells for treating 2.2 Purpose of the Asset Map hematological cancers (e.g. leukemias) Using the methodology described in and other conditions, such as sickle cell Appendix 1, this Asset Map provides anemia. In fact, bone marrow transplants a snapshot of Canadian stem cell and have become a standard of care for the regenerative medicine research. Since treatment of certain hematological cancers, this research sector could potentially be while skin stem cells are frequently used extremely broad-based, we have specifi cally

4 INTRODUCTION 2

focused on pluripotent, tissue-specifi c, and capacity for diff erentiation is usually limited cancer stem cell research, biomaterials in to cell types in the organ of origin.1 So, for terms of scaff olds or similar technologies example, neural stem cells can become any for use in regenerative medicine, and tissue type of cell in the brain or spinal cord but engineering in terms of production of stem cannot diff erentiate into heart cells unless cells and their delivery device. We have not they have been reprogrammed into induced included gene therapy (unless it involves pluripotent stem cells. stem cells) or growth factors, xeno-organs, regeneration of plants or animals (unless Cancer stem cells (also known as tumor- the studies relate to experimental models of initiating cells) are a resilient subset of human conditions) or companies working cells found in tumors with the capacity to in regenerative medicine. self-renew and diff erentiate. Th ey’ve been identifi ed in many types of solid tumor 2.3 Description of Stem Cells cancers, including cancer of the breast, Th is Asset Map distinguishes between three head and neck, lung, prostate, pancreas overall types of stem cell. Th e two major and glioblastoma. Cancer stem cells appear stem cell types are pluripotent and tissue- to be preferentially resistant to both specifi c (also known as adult or stromal). standard chemotherapy and radiotherapy. Th e third type of stem cell specifi cally Although cancer stem cells are not part targeted in this report are cancer stem cells, of regenerative medicine (they regenerate a type of tissue-specifi c cell. cancer tissues thereby destroying normal tissues), they are an important aspect of Pluripotent stem cells have the ability to stem cell research. give rise to all kinds of cell in the body, such as those of the heart, lungs, muscles, skeleton, or brain. Th ese unspecialized stem cells are derived from either embryos or from adult stem cells that have been reprogrammed (or “induced”) to enter an embryonic stem cell–like state. Th e latter are called induced pluripotent stem cells.

Tissue-specific stem cells have been identifi ed in many organs and tissues, including brain, bone marrow, peripheral blood, blood vessels, skeletal muscle, skin, teeth, heart, gut, liver, ovarian epithelium, and testis. Th ey are undiﬀ erentiated cells that are able to self renew and diﬀ erentiate. Since their primary role in a living organism is to maintain and repair the tissue in which they are found, their

5 inside 3.1 Canada’s Global Position in Stem Cell and Regenerative Medicine Research 3.2 Funding for Stem Cell and Regenerative Medicine Research 3.3 Stem Cell and Regenerative Medicine Research Centres 3.4 Funding and Researchers by University and Province overvieW of steM Cell and regenerative MediCine researCH in Canada

3.1 Canada’s Global Position • Drs. Janet Rossant and Andras Nagy fi rst in Stem Cell and Regenerative proved the inherent pluripotential nature Medicine Research of an embryonic stem cell Canada has been a leader in the stem cell • Dr. John Dick discovered cancer stem research fi eld since Canadian researchers cells Drs. James Till and Ernest McCulloch of • Dr. Sam Weiss was the fi rst to identify the Princess Margaret Hospital/Ontario neural stem cells in the brain Cancer Institute in Toronto fi rst proved • Dr. Connie Eaves discovered breast stem the existence of stem cells (hematopoietic) cells almost 50 years ago.2 For this achievement, • Dr. Michael Rudnicki identifi ed muscle they were awarded the 2005 Lasker Prize and cardiac stem cells6 (oft en described as America’s “Nobel”).3 • Dr. Freda Miller demonstrated the Th eir work has contributed to the existence of stem cells in adult skin tissue development of several lifesaving therapies, • Dr. Derek van der Kooy identifi ed retinal such as bone-marrow transplantation to stem cells treat cancer. In fact, more than 42,000 • Dr. Mick Bhatia developed a process to people worldwide have been treated transform skin cells into stem cells.7 using blood stem cells to renew their blood supply.4 Furthermore, through the In fact, Canada’s importance in continued training of researchers in their hematopoietic stem cell research up until and their former students’ labs, Canada has at least 2000 was illustrated by a Nature continued to make signifi cant contributions Immunology review that found 15 of the 32 in this area:5 most important papers in the fi eld over the

7 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE

period from 1960–2000 were authored by 3.2 Funding for Stem Cell and Canadians.8 In the fi eld of embryonic stem Regenerative Medicine Research cell research, Canada ranked second in the Th e majority of funding information number of publications from 1991–2001, was obtained from federal government and fi rst in both total citations and citations sources. Funding information was also 9 per paper. available on the Terry Fox Foundation (TFF), US National Institutes of Health However, in recent years Canada has been (NIH), AllerGen, the Ontario Government, slipping in importance, mainly because and the Saskatchewan Health Research of a slowdown in comparative research Foundation websites. Dollar fi gures were funding. Th us, according to the MaRS not provided on the websites of other Regenerative Medicine 2009 Industry provincial governments. Although the 10 Briefi ng report, in 2009 Canada occupied SCN breaks down its funds for individual 4th position in the global rankings of research projects, only total NCE funding stem cell researching countries aft er the for the Network was used in the analysis United States (US), United Kingdom (UK), (see Appendix 1 Methodology). and South Korea in terms of government funding and 3rd in terms of infl uential A minimum of $277.5 million from the stem cell patents (aft er the US and UK), aforementioned sources was spent on stem although it still had a leading position (1st) cell and regenerative medicine research in terms of citations. Although the South over the last fi ve years (2006/7–2010/11). Korean investments mentioned above have As illustrated in Figure 1, CIHR was the probably declined recently following the largest funder, providing 36% of the funds. bogus cloning research results of Hwang, Th e NCE funds, at 10% of the total, were other governments (e.g., Germany, the those dedicated to the SCN. EU) and US states have been making signifi cant and growing investments Based on the data contained in the BC (Drew Lyall [Executive Director, SCN], Regenerative Medicine Asset Map, the personal communication). Th us, since aforementioned funders included in this 2007, individual US states other than analysis probably account for only 50%–60% of California have promised over $1 billion funding in stem cell and biomaterials research in stem cell research funding, generally for regenerative medicine. Th us, over the last over a 10 year period (e.g., Connecticut fi ve years, approximately $460 million – $560 $100 million, New Jersey $250 million and million were probably spent on research into 11 New York $600 million), while Wisconsin these fi elds. Information contained on the has established a $750 million public- websites of various researchers indicates that 12 private partnership for such research. other funders include: California alone is investing $3 billion in the full spectrum of stem cell research • ALS Society of Canada and therapeutic development, from • Canadian Cancer Society fundamental research to manufacturing • Canadian Breast Cancer Foundation 13 facilities to clinical trials and beyond. • Christopher Reeve Foundation (US) • Heart and Stroke Foundation (of Canada and Ontario)

8 OVERVIEW OF STEM CELL AND REGENERATIVE MEDICINE RESEARCH IN CANADA 3

2% Genome Canada

1% Other*

5% ON Govt

3% NIH (US) 3% NSERC 8% CRC 36% CIHR

9% TFF

10% NCE

23% CFI

* Other includes AllerGen, the Saskatchewan Health Research Foundation, and Insception Biosciences Inc.

figure 1: Source of Funding for Stem Cell & Regenerative Medicine Research 2006/7 to 2010/11 ($277.5M)

• Howard Hughes Medical Institute (US) individual research institutes within or • Juvenile Diabetes Research Foundation aﬃ liated with these universities are also (Canada and US/ International) counted (see Appendix 4), then Canada has • Muscular Dystrophy Association (Canada at least 68 centres where researchers are and US) investigating stem cells and regenerative • National Cancer Institute of Canada medicine. Information on the most • SickKids Foundation important of these centres can be found in • US Muscular Dystrophy Association Section 8. • Various companies (e.g., Roche Foundation for Anemia Research; Bayer) 3.4 Funding and Researchers by University and Province 3.3 Stem Cell and Regenerative As illustrated in Figure 2,14 65% of the Medicine Research Centres $277.5 million in funding went to Ontario As listed in Table 1, 25 of Canada’s (ON). Québec (QC) received 15% followed universities are associated with stem cell by British Columbia (BC) and Alberta (AB) and regenerative medicine research. If the (9% each).

9 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE

2% Other* table 1. Canadian Universities Associated with Stem Cell and Regenerative Medicine Research

provinCe universitY

9% AB BritisH ColuMBia (BC) 9% BC Simon Fraser U. U. British Columbia U. Victoria alBerta (aB) 15% QC U. Alberta U. Calgary sasKatCHeWan (sK) 65% ON U. Saskatchewan ManitoBa (MB) * Other includes MB, SK, NB, NS, NL. U. Manitoba ontario (on) Carleton U. figure 2: Total Funding by Province 2006/7 to 2010/11 (Total $277.5M) McMaster U. Queen’s U. U. Guelph U. Toronto U. Ottawa $11 7M U. Toronto U. Waterloo U. Western Ontario York U. QuÉBeC (QC) École polytechnique de Montréal U. Ottawa McGill U. $42.8M U. Montreal U. Laval UBC McMaster U. $25.7M U. Montréal $23.2M U. Alberta McGill U. $14M $14.4M U. Québec à Montréal $9.7M U. Sherbrooke figure 3: University Funding Over $10M (2006/7 to 2010/11) nova sCotia (ns) Dalhousie U. neW BrunsWiCK (nB) New Brunswick Heart Centre neWfoundland & laBrador (nl) Memorial U.

10 OVERVIEW OF STEM CELL AND REGENERATIVE MEDICINE RESEARCH IN CANADA 3

Associated with the fact that Ontario Ottawa (8%), McGill University (8%), and received the most funding, the University Université de Montréal (8%) (Figure 5 and of Toronto received the lion’s share of Appendix 4). Information on individual funds between 2006/7 and 2010/11, at $117 research institutions aﬃ liated with these million (Figure 314). All other universities universities can be found in Section 8. received less than $50 million.

ON Using the defi nitions stated in section 2.2. 195 and the Methodology (Appendix 1), 416 researchers (in professor, associate professor, or similar positions) were identifi ed as working in the fi eld of stem cells and regenerative medicine research. A list of them can be found in Appendix 3a. Although all these researchers have QC obtained grants for stem cell and related 102 research and/or mention stem cell and related research on their websites, it should be noted that they oft en work in additional BC research areas and stem cells may not be 53 their key focus. AB 37

A breakdown of the number of researchers MB NS SK 5 working in each province and institution 11 NB 1 11 NL 1 can be found in Appendix 4. Th e provincial figure 4: Number of Researchers By Province spread of researchers is illustrated in Figure 4. Forty seven percent reside in Ontario, 25% in Quebec, 13% in British Columbia and 9% in AB. In terms of U. Toronto universities, the University of Toronto 110 (or its aﬃ liated institutions) houses by far the greatest number of researchers (26%), followed by the University of British Columbia (12%), the University of

UBC 50 U. U. McGill Ottawa U. Montreal 33 U. 34 32 U. U. Laval Western McMaster U. U. Calgary 23 Alberta Ontario 19 21 16 17

figure 5: Number of Researchers By University

11 inside 4.1 Pluripotent Stem Cells 4.2 Tissue-Specifi c Stem Cells (Somatic) 4.3 Cancer Stem Cells 4.4 Tissue Engineering foCus of steM Cell and tissue engineering researCHers Of the 416 researchers working in stem 4.1 Pluripotent Stem Cells cell and regenerative medicine research, As described previously, pluripotent stem 303 (73%) work with stem cells of some cells consist of embryonic and induced type, while 79 (19%) work in tissue pluripotent stem cells. Of the 49 researchers engineering (Figure 6). Th e others work who work only with pluripotent stem cells, in social sciences and humanities (n=16), the majority focus on embryonic stem cells bioprocessing (n=6), various stem cell (84% exclusively, another 12% working technologies such as high throughput with both types, i.e., 96% in total). Similarly sorting/analysis or cryopreservation (n=9), with the 17 who work with both pluripotent or their regenerative medicine research and tissue-specifi c cells, 82% focus on focus was unspecifi ed (n=3). embryonic stem cells (65% exclusively, another 17% working with both types). Within the stem cell research area, the Th us, of all 66 researchers who work with majority of researchers (54%, n=166) work pluripotent stem cells, whether or not with tissue-specific stem cells. Forty nine exclusively, 92% work with embryonic stem (16%) investigators work with pluripotent cells. Twenty percent (n=13) of researchers stem cells, while 30 work with cancer working with pluripotent stem cells work stem cells (10%). Another 29 (10%) work with those that have been induced (four with a number of different stem cell types [6%] with induced pluripotent stem (“various”), with at least 17 working cells only, with or without tissue-specifi c with both tissue-specific and pluripotent cells; and nine [14%] with both types (Figure 7). The specific targets of many of pluripotent stem cells, again with or of these researchers can be found in without tissue-specifi c cells) (Figure 8). Appendix 3b. Individual researchers working with each group of cells are listed in Appendix 3b.

13 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE

4% Other

4% Social Sciences & Humanities

19% Tissue Engineering

73% Stem Cells

figure 6: Percentage of Researchers Working in Each Major Discipline (n=416)

10% Stem Cells: Unspeciﬁ ed (n=29)

10% Stem Cells: Various (n=29)

10% Stem Cells: Cancer (n=30)

16% Stem Cells: Pluripotent (n=49)

54% Stem Cells: Tissue-Speciﬁ c (n=166)

figure 7: Focus of Stem Cell Research (n=303)

4.2 Tissue-Speciﬁ c Stem Cells with hematopoietic cells. Th e next most (Somatic) important stem cell types are bone marrow/ Th e majority of Canadian stem cell mesenchymal and neural cells. Bone researchers work with tissue-specifi c cells. marrow contains at least two kinds of stem Th ese can take many diﬀ erent forms as cells: hematopoietic stem cells that form all shown in Figure 9. types of blood cells and mesenchymal stem cells that can generate bone, cartilage, fat, Of the 166 researchers who only work with cells that support the formation of blood, 15 tissue-specifi c stem cells, 58 (36%) work and fi brous connective tissue. In most

14 FOCUS OF STEM CELL AND TISSUE ENGINEERING RESEARCHERS 4

2% Unspeciﬁ c Pluripotent & Tissue-Speciﬁ c (n=1)

3% Induced Pluripotent & Tissue-Speciﬁ c (n=2) 5% Both Pluripotent Types & Tissue-Speciﬁ c (n=3)

3% Induced Pluripotent Only (n=2)

9% Both Pluripotent Types Only (n=6)

17% Embryonic & Tissue-Speciﬁ c (n=11)

61% Embryonic Only (n=41)

figure 8: Focus of Pluripotent Stem Cell Researchers (n=66) cases where a researcher mentioned bone 4.4 Tissue Engineering marrow stem cells, the kind of stem cell was Many of those involved in tissue not specifi ed. In regard to neural stem cells, engineering work with both biomaterials these include stem cells derived from the and stem cells. However, some are just brain, spinal cord, and eye. Th e category of involved in developing the biomaterials, “other” included the few researchers who particularly scaff olds, that are required were working with the stem cells listed at to deliver and/or integrate stem cells the end of Figure 9. Two of the researchers into a person’s body. Figure 10 gives working with a number of (“various”) a breakdown of the research focus of diff erent stem cell types also worked with Canada’s 79 tissue engineers working in the these rarer stem types. Th e tissue-specifi c fi eld of regenerative medicine that includes focus of individual researchers can be found stem cells. At least 65% work with both in Appendix 3b. scaff olds and cells, while 27% work just with biomaterials. Th e focus of each tissue 4.3 Cancer Stem Cells engineering researcher can be found in As indicated in Figure 7, 30 researchers are Appendix 3b. working with cancer stem cells. Among those researchers who are working with several diff erent stem cell types, one is also working with cancer stem cells. Cancer stem cells are an important group of rare cancer cells that have the ability to self- renew, thereby maintaining and growing cancerous tissue. A list of cancer stem cell researchers can be found in Appendix 3b.

15 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE

3% Pancreas (n=5)

4% Muscle (n=7)

10% Unspeciﬁ ed Adult (n=17)

36% Hematopoietic, including cord blood (n=58)

14% Other (n=23)*

14% Neutral, including retinal (n=24)

19% Bone Marrow/Mesenchymal (n=32)

*Other includes amniotic (n=1), cardiac (n=3), dermal (n=3), fat (n=4), fetal (n=2), gastrointestinal (n=2), germline (n=3), lung (n=1), mammary (n=2 + a researcher who worked with various cell types), ovary (n=1), vascular (n=1). Another researcher who worked with various cell types worked with placental stem cells. figure 9: Focus of Tissue-Specifi c Stem Cell Researchers (n=166)

16 FOCUS OF STEM CELL AND TISSUE ENGINEERING RESEARCHERS 4

8% Tissue Engineering: Unspeciﬁ ed (n=6)

9% Biomaterials: Scaffolds (n=7)

18% Biomaterials: Unspeciﬁ ed (n=14)

65% Tissue Engineering: Stem Cells and Scaffolds (n=52)

figure 10: Focus of Tissue Engineering Researchers (n=79)

17 inside 5.1 Cancer 5.2 Neurology 5.3 Musculoskeletal 5.4 Cardiovascular 5.5 Metabolic Including Diabetes Stem Cell Network Mammary Epithelial Stem Cell Progeny, Craig Aarts, 5.6 Hematological 5.7 Other

5.8 Translational Medicine pHoto BY: diseases/Conditions targeted BY steM Cell and regenerative MediCine researCHers

Of the 416 researchers working in stem 5.1 Cancer cell and regenerative medicine research, Th e most common condition targeted 16 are investigating social science and by Canada’s researchers is cancer with humanities aspects. Th ese individuals have 94 working in this area (Figure 11). In been excluded from the disease analysis. addition, two of the nine working in Th us, the data in Figures 11 to 14 refer only hematological diseases include cancer to 400 researchers or a subset thereof. Th e research, as do nine working in the disease focus of each researcher is shown in “various” category. Th us, at least 105 (26%) Appendices 3a and 3c. investigators work in cancer research. As indicated in Figure 12, the most common As indicated in Figure 11, the highest focus of cancer research is hematological, number of researchers (n=101) work in two particularly leukemia. or more disease areas (designated “various”), such as hematological and cardiovascular, 5.2 Neurology or neurological, urological, and cutaneous Th e second most important disease focus is conditions. Th is is particularly true for those neurological. As well as the 56 individuals who focus on tissue engineering. Some of almost exclusively focused on such diseases, these individuals are referred to in the sub- at least another 10 categorized in the sections below. “various” group also work in this area. Th e most common diseases being investigated by these 66 researchers (who constitute 17% of the 400 total number of researchers) are those of the eye, spinal cord, and multiple

19 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE

2% Hematological (n=9)

3% Metabolic (n=12)

25% Various (n=101)

10% Other (n=38) 10% Cardiovascular (n=41)

12% Musculoskeletal (n=49)

24% Cancer (n=94)

14% Neurological (n=56)

figure 11: Disease Focus of Stem Cell and Regenerative Medicine Researchers (n=400)

sclerosis (Figure 13). “Other” conditions 5.4 Cardiovascular include ALS (n=2), Parkinson’s (n=2), Of the 41 researchers working almost Alzheimer’s (n=2), Rett’s syndrome (n=1), exclusively in cardiovascular research, stroke (n=2), brain or unspecifi ed injury 23 (56%) are almost entirely focused on the (n=3), neurological development (n=1), heart. In addition, 16 of those working in and olfactory (n=2). several disease areas include cardiovascular conditions among their areas of focus. Th us 5.3 Musculoskeletal at least 57 (14% of the 400 total) researchers Figure 11 indicates that 49 investigators are working on cardiovascular diseases. are almost exclusively focused on musculoskeletal conditions, including bone, 5.5 Metabolic Including Diabetes disc, ligament and cartilage formation All 12 people working on metabolic and/or regeneration and muscular diseases as shown in Figure 11 work dystrophy. Th e targeted condition is not on diabetes. In addition, five of the specifi ed or involves multiple aspects in researchers in the “various” category also 32 cases. An additional eight researchers work on diabetes. Thus 17 (4% of the 400 in the “various” category also work on total) investigators are using stem cells musculoskeletal conditions, bringing the or related tissue engineering to address total to 57 (14% of the 400 total). diabetes.

20 DISEASES/CONDITIONS TARGETED BY STEM CELL AND REGENERATIVE MEDICINE RESEARCHERS 5

*Other includes one each of colorectal, 4 Other liver, ovarian and prostate.

2 Cervix

4 Breast

6 Brain

37 Hematological

52 Not Specified

figure 12: Number of Researchers Working on Cancer (n=105)

note that in several cases, two 5 Multiple Sclerosis neurological indications were given, hence the total of the bars is more than 66. 11 Spinal Cord Injury

16 Eye

15 Other

5225 Multiple/Not Specified

figure 13: Number of Researchers Working on Neurological Conditions (n=66)

5.6 Hematological allergies, asthma, immunodefi ciency, Figure 11 shows that nine researchers and autoimmune. Five researchers are are working on hematological conditions also working on better understanding other than cancer. In addition, fi ve of the embryogenesis, while eight researchers researchers working in several disease areas are working on aspects of male and female are targeting hematological conditions. fertility (“reproduction”). Respiratory Table 2 shows a breakdown of the conditions, such as cystic fi brosis, or lung hematological focus of these 14 researchers. development or repair, are the focus of four researchers. All other conditions are 5.7 Other targeted by three researchers or fewer. Figure 14 shows all other disease areas targeted by Canada’s stem cell and 5.8 Translational Medicine regenerative medicine researchers. Although the constraints involved in the Th ose receiving the most attention are preparation of this report did not allow for immunological conditions (n=6), including a detailed analysis of researchers that are

21 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE

table 2. Number of Researchers Working Within the Hematological Disease Area (excluding Cancer) tYpe of disease nuMBer of researCHers Anemia 5 Hemophilia 4 Unspecifi ed 5

driving translational medicine (moving fi ndings from the laboratory to the clinic), many were noted during the analysis that did take place. Th irty nine of these are listed in Appendix 3d.

There is no doubt that many other researchers listed in Appendix 3a are also working to translate the basic stem cell research findings to the clinic, as the SCN indicated that its approximately 100 researchers had spent around $50 million on translational research over the past 10 years (Lyall, personal communication). Furthermore, Canada has a history of clinical innovations with stem cells. For example, clinicians at the University of Alberta published “The Edmonton Protocol” in the New England Journal of Medicine (2000), providing the first proof of principle that Type 1 Diabetes could be treated effectively by using replacement beta cells (in this case from donated pancreases).16 This innovation has spurred researchers to explore the potential of deriving functional beta cells from stem cells. In addition, Canadian clinicians developed the “Halifax Protocol” which is now being used in international clinical trials to treat Parkinson’s disease17. Our researchers are also developing new protocols for multiple sclerosis, graft-versus-host disease, stroke, pulmonary hypertension, neuroblastoma and other diseases that can be addressed with stem cells.

22 DISEASES/CONDITIONS TARGETED BY STEM CELL AND REGENERATIVE MEDICINE RESEARCHERS 5 table 2. Number of Researchers Working Within the Hematological Disease Area (excluding Cancer) 1 Aging tYpe of disease nuMBer of researCHers

Anemia 5 1 Cardiopulmonary Hemophilia 4 Unspecifi ed 5 3 Cutaneous

3 Dental

5 Embryogenesis

1 Gastrointestinal

2 Genetic

6 Immunological

1 Infection

1 Renal

5 Reproduction—Female

3 Reproduction—Male

4 Respiratory

2 Urological

figure 14: Number of Researchers Working on “Other” Conditions (n=38)

23 inside 6.1 Biobanks 6.2 Other Relevant Facilities relevant support faCilities 6.1 Biobanks 6.2 Other Relevant Facilities 6.1.1 CORD BLOOD BANKS As well as the biorepositiories, there are Th ere are two public cord blood banks in lots of other facilities that may be relevant Canada: one in Montréal (Héma-Québec to stem cell researchers. Th ese include at Cord Blood Bank) and the other one in least three manufacturing/bioprocessing Edmonton (Alberta Cord Blood Bank). facilities as well as the other centres listed Th ere are also blood banks at several in Table 5. universities that have samples available for research purposes.18 Furthermore, there are private blood banks in which parents can place their baby’s blood in case of future medical problems. In addition, Canadian Blood Services are trying to establish a national cord blood bank that should be available by 2013.19 Th e blood banks listed in Table 3 are those that may be accessed for scientifi c purposes. It should be noted that this list may not be all-inclusive.

6.1.2 OTHER BIOBANKS Other biobanks include those with tissue samples (generally from cancer patients) or pluripotent stem cell lines (both embryonic and induced pluripotent) available for research purposes. Table 4 lists some of those available in Canada. Again, this list is probably not all-inclusive but includes two stem cell line banks and 15 other tissue banks. Other potential biobanks are in the planning stage, e.g., a brain tumour tissue bank in Vancouver.20

25 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE

table 3. Publicly-Available Cord Blood Banks Blood BanK Managed BY url Alberta Cord Blood Bank U. Alberta www.acbb.ca Banque publique de sang de cordon Héma-Québec www.hema-quebec.qc.ca/donner/cellules-souches/don-de- du Québec sang-de-cordon-ombilical/index.fr.html Registre des donneurs de cellules Héma-Québec www.hema-quebec.qc.ca/donner/cellules-souches/registre- souches (moelle osseuse) des-donneurs/index.fr.html Clinical-Research Cord Blood Bank of McGill University Health Centre muhc.ca/research/page/core-facilities the McGill University Health Centre Toronto Cord Blood Program Inseption Biosciences, Mount www.insception.com Sinai Hospital

table 4. Other Biobanks Available to Researchers BioBanK loCation inforMation url steM Cell lines Braley Human Stem Stem Cell and Cancer Research Has more than 15 iPS cell lines for use in fhs.mcmaster.ca/ Cell Library (HSCL) Institute (SCC-RI), Hamilton, ON regenerative medicine research. SCCRI/21 National Registry for Administered by CIHR22 A list of all human embryonic stem cell lines www.cihr-irsc. Human Embryonic derived under the auspices of an Institution gc.ca/e/39580.html Stem Cell Lines that receives Canadian Agency funds. Includes 4 cell lines (2 each in Toronto and Calgary). otHer BioBanKs Brain Tumour Tissue Lawson Research Institute, London, Collects and provides human brain tumour www.lawsonresearch. Bank ON specimens and matching clinical data for com/clinical_research/ neuro-oncology research in Canada and brain_tumour_bank.htm internationally. Breast Tumour Bank BC Cancer Research Centre, This BC Cancer Agency’s breast cancer molonc.bccrc.ca/?page_ Vancouver, BC tumour tissue repository (BREAST-TTR) id=421 comprises several important banks of breast tissues, contemporaneous as well as archival. Canadian Breast Cross Cancer Institute, Edmonton; Collaboration between CBCF—Prairies/NWT www.abtumorbank.com Cancer Foundation Tom Baker Cancer Centre, Calgary; Chapter and the Alberta Health Services, (CBCF) Tumor Bank U. of Calgary; all in AB providing a comprehensive collection of cancer specimens with related clinical information for use by researchers. Canadian Virtual Brain Toronto Western Hospital, Toronto, ON Acts as a resource for researchers to provide www.braintumourbank. Tumour Bank them with information on the types of brain ca tumour tissue samples available and direct them to the tumour tissue banking sites holding these samples.

26 RELEVANT SUPPORT FACILITIES 6

BioBanK loCation inforMation url Manitoba Breast Cancer Care Manitoba, Winnipeg, MB Provides anonymized, processed, and www.umanitoba.ca/ Tumor Bank annotated cancer tissues and data for institutes/manitoba_ translational research. institute_cell_biology/ MBTB/Index4.htm Maritime Brain Tissue Dalhousie U., NS Collects brain tissues and makes them research.medicine.dal. Bank available for researchers who are trying to ca/cores-brain.htm better understand the causes of dementia. National Cancer Queen’s U., Kingston, ON Contains unique disease specifi c collections, www.ctg.queensu.ca/ Institute of Canada housed, catalogued, and linked to an TissueBank/index.html Clinical Trials Group associated clinical dataset to support (NCIC CTG) Tissue correlative science. Bank Ontario Tumour Bank Ontario Institute for Cancer Research, Focused on collection of tumour-related www.ontariotumourbank. Toronto, ON human biospecimens for use by academic ca and industry cancer researchers. OvCaRe Gynaecologic Vancouver General Hospital and BC Contains tumour and serum samples ovcare.ca/research/ Tissue Bank Cancer Agency, Vancouver, BC from over 1,100 consenting patients. In platforms.php addition to providing research material for OvCaRe researchers, the Tumour Bank has contributed to 43 national and international research projects. PROCURE Québec Mont-Royal, QC Collects and stores standardized high www.procure. Prostate Cancer volumes of prostatic tissues, blood, urine, ca/tiki-index. Biobank clinical information and socio-demographic php?page=biobank_ data from men undergoing prostate cancer overview_introduction screening and surgery across QC and facilitates access to these resources. Québec Leukemia Cell Centre de recherche de l’Hôpital Supports basic and clinical blood cancer www.bclq.org/en/index. Bank Maisonneuve-Rosemont, Montréal, research; provides an infrastructure and html QC services aimed at facilitating the work of researchers in various fi elds, such as oncology, hematology and immunology. Le Réseau de Montréal, QC Provides tumour banks and other resources www.rrcancer.ca recherche sur le to Québec researchers. cancer du Fonds de la recherche en santé du Québec (RRCancer- FRSQ Network) Tumour Bank Sunnybrook Research Institute, Collects, stores, and distributes tissues for sunnybrook.ca/research/ Toronto, ON the following body sites: breast, prostate, content/?page=sri_core_ colorectal, gynecological. tbank_home Tumour Tissue BC Cancer Agency, The Deeley Collects anonymized and appropriately www.bccrc.ca/dept/ttr Repository Research Centre, Victoria, BC consented biospecimens (tissues and blood) and associated clinical information for use by cancer translational researchers throughout Canada and worldwide. Vancouver Prostate Vancouver Prostate Centre, Contains over 2,000 prostate cancer www.prostatecentre. Centre Biorepository Vancouver, BC specimens (both fresh frozen and paraffi n com/our-research/core- embedded), as well as an integrated facilities/biorepository database.

27 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE

table 5. Support Facilities for Stem Cell and Regenerative Medicine Research naMe desCription url Biotechnology and Pharmaceutical Develops bioprocesses to produce and purify high quality, www.polymtl.ca/bio-p2/ Processes Research Unit, École valuable biomolecules. polytechnique de Montréal, QC Centre de Recherche de l’Hôpital As well as the Québec Leukemia Cell Bank described in recherche.maisonneuve- Maisonneuve-Rosemont, Montreal, Table 4 and the CECT described below, the Centre de Recherche rosemont.org/en-ca/research/ QC de l’Hôpital Maisonneuve-Rosemont also offers other relevant technical-support-programs/ research facilities such as fl ow cytometry and an animal supply fl ow-cytometry.html facility. Centre for Applied Genomics (TCAG), Provides project support to investigators, including laboratory www.tcag.ca Hospital for Sick Children (Sick Kids), experimentation, statistical analysis and bioinformatics MaRS Centre, Toronto, ON support. It also has a Biobanking and Databasing Facility that provides DNA extraction from lymphoblasts, fi broblasts and other cell types, archiving of white cell pellets, preparation and immortalization of cell lines, and comprehensive databasing and tracking of samples and/or cell lines within the facility. Centre of Excellence for Cellular Opening in 2011, CECT will conduct leading-edge research recherche.maisonneuve- Therapy (CECT), Centre de Recherche on stem cells, the immune system and cancer; train young rosemont.org/en-ca/research/ de l’Hôpital Maisonneuve-Rosemont, researchers; and bring together basic and clinical research. It research-units/centre-of- Montreal, QC will offer bioreactors, a high speed cell sorter, FACS analyzer, a excellence-for-cellular-therapy. level BSCL2 facility, and other state-of-the-art equipment. html LOEX (Experimental Organogenesis Works with epidermal culture and a self-assembly approach to www.cha.quebec.qc.ca/en/ Laboratory—Laboratoire tissue engineering. Activities cover four major areas: (1) Stem www/research/fi elds-of- d’organogénèse expérimentale), cells, differentiation and cellular interactions; (2) Cutaneous, research/tissue-engineering- U. Laval. QC cardiovascular, orthopedic, ophthalmologic, pulmonary and and-regeneration/index.html; urinary tissue reconstruction; (3) Biological applications www.loex.qc.ca/recherche. of reconstructed tissues (physiology, pathophysiology, interets.php?langue=2 pharmacology, toxicology, transplantation) and pre-clinical trials; (4) Clinical applications of cellular and tissue-based therapies. Ottawa Hospital Research Institute With 230,000 square feet of dedicated basic and clinical www.ohri.ca/About/Facilities. (OHRI), Ottawa, ON research space, the OHRI houses good manufacturing practice asp laboratories, advanced imaging equipment, fl ow cytometry facilities, a clinical pharmacokinetics laboratory and other facilities. As a member of the Shared Core Facilities Initiative, OHRI makes many of its facilities available to the broader academic health research community in Ottawa. Pharmaceutical Production Research Commercializing media development and bioreactor protocols www.pprf.ca Facility, Calgary, AB for the expansion of mammalian neural stem cells, as well as developing expansion protocols for pancreatic endocrine tissue and progenitor cells, mesenchymal stem cells, hepatic oval stem cells, embryonic stem cells and mammary stem cells. Philip S. Orsino Cell Therapy Facility, A state-of-the-art facility offering Good Manufacturing Practice www.uhnres.utoroto.ca/ Princess Margaret Hospital, Toronto, (GMP) grade cell and tissue processing capabilities. facilities/psoctf/ ON23

28 RELEVANT SUPPORT FACILITIES 6

naMe desCription url Ontario Human Induced Pluripotent Develops best practices in the technologies of reprogramming www.ontarioips.ca Stem Cell Facility, MaRS Centre, with a focus on the establishment and banking of patient- Toronto, ON specifi c primary fi broblast cell lines, and the subsequent generation and characterization of iPS cells. StemBase, Ottawa Health Research The largest stem cell gene expression database in the world www.stembase.ca Institute, ON containing information on genomic and proteomic analysis of stem cells. Toronto Centre for Phenogenomics, Conducts and supports genetic research involving generation of www.phenogenomics.ca Mount Sinai Hospital, Toronto, ON mutant mice, physiological phenotyping, behavioural analysis, imaging, pathology and cryopreservation for storage and distribution. Services include generation of novel ES cell lines, and expansion of ES cell clones.

29 inside Skin-derived precursors differentiated into Schwann cells, Stem Cell Network Shaalee Dworski, 7.1 National and International Networks

7.2 Provincial Networks pHoto BY: netWorKs 7.1 National and International Networks Canada’s stem cell and regenerative medicine researchers are members of a number of diﬀ erent relevant national and international networks. Th ese include those networks described in Table 6. Unless otherwise indicated, the description information has been sourced from the URL listed in the table. 7.2 Provincial Networks Th ere are also a number of provincial research networks to which researchers belong. Th ese include those listed in Table 7.27

31 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE

table 6. National and International Stem Cell and Regenerative Medicine Networks naMe desCription url national Stem Cell Network (SCN) Headquartered at U. Ottawa, ON, this federal government-funded www.stemcellnetwork.ca Network of Centers of Excellence (NCE) was formed in 2001 and currently includes 96 researchers and 167 industry, public service and academic partners. It is a catalyst for enabling translation of stem cell research into clinical applications, commercial products or public policy. It will receive $63.62M in federal government funding between 2001 & 2012. Centre for Commercialization of This federal government-funded Centre of Excellence for www.ccrm.ca Regenerative Medicine (CCRM) Commercialization and Research (CECR) was established at the end of 2010 at U. Toronto, ON. It aims to accelerate the commercialization of regenerative medicine technologies by bringing together business leadership and innovative stem cell and biomaterial technology development. It will receive $15M in federal government funding between 2011 and 2015.24 AllerGen NCE Inc. Allergy and asthma research federal government-funded NCE www.allergen-nce.ca headquartered at McMaster U., ON. Formed in 2004, it funds some stem cell research in asthma and infl ammatory disease. C17 Council Organization composed of the institutionally appointed heads www.c17.ca of the 16 pediatric hematology, oncology, and stem cell transplantation programs in Canada. Acts as an authoritative Canadian voice representing the interests of children and adolescents with cancer and blood disorders. Canadian Blood & Marrow Transplant National, voluntary, multi-disciplinary organization providing www.cbmtg.org (BMT) Group leadership and promoting excellence in patient care, research and education in the fi eld of blood and marrow transplantation. Canadian Tumour Repository Network A translational cancer research resource, funded by CIHR, that www.ctrnet.ca (CTRNet) furthers Canadian health research by linking cancer researchers with provincial tumour banks. international Cancer Stem Cell Consortium (CSCC) Founded in 2007 by a group of Canadian funding agencies (CFI, www. CIHR, Genome Canada, Ontario Institute for Cancer Research, cancerstemcellconsortium.ca Stem Cell Network) to support international collaboration on research on cancer stem cells. Currently has a strategic partnership with the California Institute for Regenerative Medicine. Aims to secure and manage an estimated $500M in research funds during an initial 5-year period (2009–2014).25 International Consortium of Stem Cell HQ in Ottawa, ON. Consists of 18 stem cell networks from more www.stemcellconsortium.org Networks than 10 countries; currently chaired by Dr. Michael Rudnicki, Scientifi c Director of Canada’s Stem Cell Network. International Society for Cellular A global association driving the translation of scientifi c research www.celltherapysociety.org Therapy to deliver innovative cellular therapies to patients that was established in 1992. Dr. Armand Keating is on the Mesenchymal and Tissue Stem Cells Committee. International Society of Stem Cell An independent, nonprofi t organization formed to foster www.isscr.org Research the international exchange of information on stem cell research between the world’s leading stem cell scientists and researchers. HQ in Deerfi eld, Illinois, US. Drs. Connie Eaves and Derek van der Kooy are on the Board of Directors. Dr. Gordon Keller is a member of the Global Advisory Council.

32 NETWORKS 7

naMe desCription url International Stem Cell Forum Consists of 14 leading funders of stem cell research from N/A 13 countries. Founded in January 2003 to encourage international collaboration and funding support for stem cell research. Canada’s member is CIHR.26 Pediatric Bone and Marrow A voluntary group of clinicians and scientists that includes over www.pbmtc.org Transplant Consortium (PBMTC) 100 pediatric PBMTC centers in Canada, US, Australia and New Zealand. Purpose is to engage in scientifi c and educational activities related to the use of hematopoietic stem cells in the treatment of diseases of children and adolescents. Canadian members include Alberta Children’s Hospital, BC Children’s Hospital, Cancer Care Manitoba, Centre Hospitalier Universitaire Ste Justine Chu Ste-Justine, McGill University Health Center— Montreal Children’s Hospital, and Sick Kids.

33 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE

table 7. Provincial Networks for Stem cell and Regenerative Medicine Researchers

naMe reaCH url BritisH ColuMBia BC Network for Aging Research British Columbia www.bcnar.ca Child & Youth Health Research Network British Columbia www.cyhrnet.ca BC Clinical Genomics Network British Columbia www.bccgn.ca BC Preclinical Research Consortium British Columbia www.bcprc.ca BC Biolibrary British Columbia www.bcbiolibrary.icapture.ubc.ca BC Proteomics Network British Columbia www.bcproteomicsnetwork.ca British Columbia Pancreatic Cancer British Columbia www.bccancer.bc.ca/RES/ResearchPrograms/bcpcr/ Research Net default.htm Brain Research Centre British Columbia www.brain.ubc.ca ICORD (International Collaboration On British Columbia icord.org Repair Discoveries) Centre for Lymphoid Cancer British Columbia www.bccancer.bc.ca/RES/ResearchPrograms/ LymphoidCancers/default.htm alBerta Joint Injury and Arthritis Research Group Alberta www.albertahealthservices.ca/services. asp?pid=service&rid=1715 sasKatCHeWan Airways Research Group U. Saskatchewan www.medicine.usask.ca/research/health-research- groups/airways-research-group/index.html ManitoBa Manitoba Neuroscience Network Manitoba www.sbrc.ca/mnn/ Spinal Cord Research Centre U. Manitoba www.scrc.umanitoba.ca/SCRC/About.html Medical Genetics Research Group Manitoba www.umanitoba.ca/faculties/medicine/units/biochem/ research/genetics.html ontario Health Services Research Network (cancer Ontario www.oicr.on.ca/newsreleases/2010/Backgrounder_ research) Health_Services_Research_July122010.pdf Imaging Network Ontario Ontario sunnybrook.ca/research/content/?page=sri_proj_imno_ home Ontario Cancer Genetics Network Ontario www.cancercare.on.ca/cms/one.aspx?pageId=10051 Ontario Stem Cell Initiative (virtual network Ontario www.ontariostemcell.ca of over 60 stem cell scientists in Ontario) Ontario Translational Research Network Ontario www.otrn.ca (cancer research) QuÉBeC Network for Oral and Bone Health Research Québec www.rsbo.ca Vision Research Network Québec www.visionnetwork.ca

34 NETWORKS 7

naMe reaCH url Cancer Research Network Québec www.rrcancer.ca Réseau de thérapie cellulaire et tissulaire Québec www.reseauthecell.qc.ca (ThéCell) Groupe de recherche en sciences et Institut de génie biomédical of www.polymtl.ca/recherche/rc/unites/details. technologies biomédicales (GRSTB) École polytechnique Montréal php?NoUnite=42 Groupe de recherche sur le système Faculty of Medicine of Université www.grsnc.umontreal.ca nerveux central de Montréal Montréal Diabetes Research Center Montréal Institutions www.montreal-diabetes-research-center.org/en/index.asp MaritiMe provinCes Atlantic Path Research Network (cancer Nova Scotia, New Brunswick, atlanticpath.ca/research/research.html research) Prince Edward Island, Newfoundland and Labrador New Brunswick Cancer Network New Brunswick www.gnb.ca/0051/cancer/index-e.asp

35 inside 8.1 Key Researchers 8.2 Key Research Institutions KeY researCHers and institutions

8.1 Key Researchers • Janet Rossant, University of Toronto— Th ere are several ways to measure the scores high on all six criteria importance of a researcher, including: • Connie Eaves—scores high on four criteria • Key contributions • Keith Humphries—scores high on four • Amount of research funding received criteria • Position within key research institutes • Armand Keating, University of Toronto— • Endowed Chair scores high on fi ve criteria • Number of publications • Gordon Keller—scores high on four criteria • Number of citations. • Freda Miller—scores high on four criteria • Andras Nagy, University of Toronto— Each of the six criteria metrics provides scores high on fi ve criteria diﬀ erent outcomes, as described below, • Michael Rudnicki, University of Ottawa— but the 21 researchers listed in Table 8 scores high on four criteria all score high on key contributions and/ • Guy Sauvageau, Université de Montréal— or levels of research funding ($5 million scores high on four criteria. or greater used as excellence level). Th ree researchers score high on all criteria, while In terms of amount of funding received at least eight other researchers score high within the constraints of the methodology on a minimum of four of the six criteria used in this Asset Map (see Appendix 1), (from the information that was available 51 of the 416 researchers received funding for this project; publication, citation, and of more than $1 million over a five year contributions data are missing for a number period (2006/7 to 2010/11). The 13 who of researchers): received funding of over $5 million are all listed in Table 8, as are two researchers • Mick Bhatia, McMaster University— who have recently received over $5 million scores high on all six criteria of funding for use over the next five years • John Dick, University of Toronto—scores from either the Ontario Government high on all six criteria (Greenblatt) or Networks of Centres of

37 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE

Excellence (NCE) (Zandstra). Thirteen are high level research professorships of the 21 key researchers are directors created by the Canadian Government of or hold similar positions within their to attract and retain some of the world’s research institutions and 11 of these most accomplished and promising received funding of over $5 million. minds. Eleven Chairholders who have made significant achievements in stem As mentioned above, another way of cell/regenerative medicine research measuring a researcher’s importance is and/or received high levels of funding whether or not (s)he holds an endowed (over $5 million) are shown in Table 8 Chair. Eighty one of the 416 researchers while the rest are listed in Appendix 3a. are Chairholders, 69 of whom are Canada Furthermore, using data from Scopus Research Chairs (CRCs). The latter (www.scopus.com), Industry Canada’s Life

table 8. Researchers Who Have Made or Are Making Signifi cant Contributions to Stem Cell Research Citation universitY funding BetWeen # puBs. indeX KeY ContriButions (froM info. supplied BY industrY researCHer researCH institution and position affiliation endoWed CHair 2006/07 & 2010/11a 2005–2010b (H-indeX)b Canada onlY, unless otHerWise indiCated) Bhatia, Mickc Director and Senior Scientist, Stem Cell and Cancer McMaster U., ON CRC in Human Stem Cell Biology; $5M+ 22 13 Developed a process to transform skin cells into stem cells.29 Research Institute Krembil Chair in Stem Cell Biology Dick, John Director, Program in Cancer Stem Cells—Genesis, Ontario U. Toronto, ON CRC in Stem Cell Biology $5M+ 18 13 Isolated the fi rst cancer stem cell, in acute myeloid leukemia (1994), and Institute for Cancer Research subsequent ones in other tumors. Dirks, Peter Scientist & Principal Investigator, Hospital for Sick Children U. Toronto < $1M N/A N/A Isolated and characterized cancer stem cells from human brain tumours of (Sick Kids) different phenotypes that express neural stem cell markers and have stem cell- like behaviour in vitro and in vivo. Eaves, Connie Director, Co-founder, and Senior Scientist, Terry Fox UBC, BC $1M–$2.5M 30 14 Pioneering research in basic blood stem cell biology. Discovered breast stem Laboratory; VP Research BC Cancer Agency cells. Developed stem cell assays. Greenblatt, Jack Principal Investigator, The Donnelly Centre, Banting and U. Toronto, ON $1M–$2.5M N/A N/A A $5.27M grant for 2011–2014 from the Ontario Government for Protein Best Department of Medical Research Complexes in the Epigenetics of Human Disease and Stem Cell Fate research. Humphries, Keith Director & Distinguished Scientist, Terry Fox Laboratory, UBC, BC $5M+ 15 8 N/A BC Cancer Agency Keating, Armand Director, Cell Therapy Program and the Orsino Cell Therapy U. Toronto, ON Epstein Chair in Cell Therapy & $5M+ 33 12 N/A Translational Research Lab., Princess Margaret Hospital Transplantation Keller, Gordon Director, McEwen Centre for Regenerative Medicine and U. Toronto, ON CRC in Embryonic Stem Cell $5M+ N/A N/A Demonstrated that human heart progenitor cells could be grown from Senior Scientist, Ontario Cancer Institute Biology embryonic stem cells (2008).30 Korbutt, Gregory Director, Human Islet Quality Control Laboratory, Alberta U. Alberta, AB $5M+ N/A N/A N/A Diabetes Institute Miller, Freda Senior Scientist, Developmental & Stem Cell Biology U. Toronto, ON CRC in Developmental $4M–$5M 16 11 Demonstrated the existence of stem cells in adult skin tissue, and that they program, Hospital for Sick Children (Sick Kids) Neurobiology could be used to grow nerve cells that could potentially help people with spinal cord injuries or Parkinson’s disease. Nagy, Andrasd Senior Investigator, Samuel Lunenfeld Research Institute, U. Toronto, ON CRC in Stem Cells and $5M+ 18 8 Reconstituted a mouse from a single embryonic stem cell, thus proving the Mount Sinai Hospital and Investigator, McEwen Centre for Regeneration cells’ inherent and defi ning characteristic of pluripotency.31 Established Regenerative Medicine Canada’s fi rst—and to date only—human embryonic stem cell lines (2005). Developed method to create induced pluropotent stem cells (iPS) cells without the use of retroviruses (2009). Paige, Christopher VP Research, Ontario Cancer Institute U. Toronto, ON $5M+ N/A N/A N/A

38 KEY RESEARCHERS AND INSTITUTIONS 8

Science Industries Branch and Science- • Amount of funding received Metrix on publications and citations,28 • Number of researchers at least nine of the 21 researchers had • Number of endowed Chairs a significant number of publications • Number of publications and citations. and citations. The majority of the other researchers probably also had numerous Th ese criteria metrics give slightly diﬀ erent well-cited publications but the data for results in terms of key institutions. these could not be collected for this report. As indicated in section 3.3 and Table 1, 8.2 Key Research Institutions 25 of Canada’s universities are associated As with researchers, there are several ways with stem cell and regenerative medicine of measuring institutional importance, research. Associated with the fact that including: Ontario received 65% of funding (Figure 2

Citation universitY funding BetWeen # puBs. indeX KeY ContriButions (froM info. supplied BY industrY researCHer researCH institution and position affiliation endoWed CHair 2006/07 & 2010/11a 2005–2010b (H-indeX)b Canada onlY, unless otHerWise indiCated) Bhatia, Mickc Director and Senior Scientist, Stem Cell and Cancer McMaster U., ON CRC in Human Stem Cell Biology; $5M+ 22 13 Developed a process to transform skin cells into stem cells.29 Research Institute Krembil Chair in Stem Cell Biology Dick, John Director, Program in Cancer Stem Cells—Genesis, Ontario U. Toronto, ON CRC in Stem Cell Biology $5M+ 18 13 Isolated the fi rst cancer stem cell, in acute myeloid leukemia (1994), and Institute for Cancer Research subsequent ones in other tumors. Dirks, Peter Scientist & Principal Investigator, Hospital for Sick Children U. Toronto < $1M N/A N/A Isolated and characterized cancer stem cells from human brain tumours of (Sick Kids) different phenotypes that express neural stem cell markers and have stem cell- like behaviour in vitro and in vivo. Eaves, Connie Director, Co-founder, and Senior Scientist, Terry Fox UBC, BC $1M–$2.5M 30 14 Pioneering research in basic blood stem cell biology. Discovered breast stem Laboratory; VP Research BC Cancer Agency cells. Developed stem cell assays. Greenblatt, Jack Principal Investigator, The Donnelly Centre, Banting and U. Toronto, ON $1M–$2.5M N/A N/A A $5.27M grant for 2011–2014 from the Ontario Government for Protein Best Department of Medical Research Complexes in the Epigenetics of Human Disease and Stem Cell Fate research. Humphries, Keith Director & Distinguished Scientist, Terry Fox Laboratory, UBC, BC $5M+ 15 8 N/A BC Cancer Agency Keating, Armand Director, Cell Therapy Program and the Orsino Cell Therapy U. Toronto, ON Epstein Chair in Cell Therapy & $5M+ 33 12 N/A Translational Research Lab., Princess Margaret Hospital Transplantation Keller, Gordon Director, McEwen Centre for Regenerative Medicine and U. Toronto, ON CRC in Embryonic Stem Cell $5M+ N/A N/A Demonstrated that human heart progenitor cells could be grown from Senior Scientist, Ontario Cancer Institute Biology embryonic stem cells (2008).30 Korbutt, Gregory Director, Human Islet Quality Control Laboratory, Alberta U. Alberta, AB $5M+ N/A N/A N/A Diabetes Institute Miller, Freda Senior Scientist, Developmental & Stem Cell Biology U. Toronto, ON CRC in Developmental $4M–$5M 16 11 Demonstrated the existence of stem cells in adult skin tissue, and that they program, Hospital for Sick Children (Sick Kids) Neurobiology could be used to grow nerve cells that could potentially help people with spinal cord injuries or Parkinson’s disease. Nagy, Andrasd Senior Investigator, Samuel Lunenfeld Research Institute, U. Toronto, ON CRC in Stem Cells and $5M+ 18 8 Reconstituted a mouse from a single embryonic stem cell, thus proving the Mount Sinai Hospital and Investigator, McEwen Centre for Regeneration cells’ inherent and defi ning characteristic of pluripotency.31 Established Regenerative Medicine Canada’s fi rst—and to date only—human embryonic stem cell lines (2005). Developed method to create induced pluropotent stem cells (iPS) cells without the use of retroviruses (2009). Paige, Christopher VP Research, Ontario Cancer Institute U. Toronto, ON $5M+ N/A N/A N/A

39 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE

table 8. cont’d Citation universitY funding BetWeen # puBs. indeX KeY ContriButions (froM info. supplied BY industrY researCHer researCH institution and position affiliation endoWed CHair 2006/07 & 2010/11a 2005–2010b (H-indeX)b Canada onlY, unless otHerWise indiCated) Rossant, Janet Chief of Research, Hospital for Sick Children (Sick Kids) U. Toronto, ON Lombard Insurance Chair $5M+ 25 11 Reconstituted a mouse from a single embryonic stem cell, thus proving the cells’ inherent and defi ning characteristic of pluripotency.32 Rudnicki, Michael Director and Senior Scientist, Sprott Centre for Stem Cell U. Ottawa CRC in Molecular Genetics $5M+ N/A N/A Discovered adult muscle stem cells. Research (also Scientifi c Director, Stem Cell Network) Sauvageau, Guy Chief Executive Offi cer and founding Scientifi c Director, U. Montréal, QC CRC in the Molecular Genetics $5M+ N/A N/A Developed the use of recombinant proteins allowing for the expansion of the Institute for Research in Immunology and Cancer of Stem Cells hematopoietic stem cells. Sefton, Michael Principal Investigator, Donnelly Centre for Cellular and U. Toronto, ON Michael E. Charles Chair in $5M+ N/A N/A N/A Biomolecular Research Chemical Engineering Till, Jim Senior Scientist, Ontario Cancer Institute U. Toronto, ON Semi-retired N/A N/A Demonstrated the existence of stem cells (1961). van der Kooy, Derek Professor, Department of Medical Genetics and U. Toronto, ON $2.5M–$4M 16 10 Identifi ed retinal stem cells in mice (1994). Identifi ed retinal stem cells in the Microbiology human eye (2000). Weisel, Richard Director, Toronto General Research Institute U. Toronto, ON $5M+ N/A N/A N/A Weiss, Samuel Director, Hotchkiss Brain Institute U. Calgary, AB $1M–$2.5M N/A N/A Identifi ed stem cells in the adult human brain (1992)—discovered a mammalian central nervous system (CNS) stem cell. Zandstra, Peter McEwen Centre for Regenerative Medicine, University U. Toronto, ON CRC in Stem Cell Bioengineering < $1M N/A N/A $15M from 2011 for an NCE CECR: Centre for Commercialization of Regenerative Health Network and Institute of Biomaterials and Medicine. Biomedical Engineering, Donnelly Centre

a Funding (principally federal) collected according to Methodology described in Appendix 1—includes individual investigator funds from Stem Cell Network. b Only publication and citation data supplied within an internal document provided by Industry Canada’s Life Science Industries Branch were used here—see above text for reference. c Also has a 2011–2014 grant from the Ontario Government of $9.2M for the Ontario Consortium for Regeneration Inducing Therapeutics (OCRiT). d Also has a 2011–2014 grant from the Ontario Government of $7.25M for a project titled: Molecular pathways of reprogramming—from discovery to novel therapeutics.

40 KEY RESEARCHERS AND INSTITUTIONS 8

41 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE

above), the University of Toronto received of Calgary, McMaster University, the the lion’s share of funds between 2006/7 University of Ottawa, McGill University and 2010/11, at $117 million (see Figure 3 and Université de Montréal. In addition, above). Th is was followed by the University although housing fewer than fi ve of Ottawa and Université de Montréal. In researchers (by this report’s analysis), the terms of researchers, the order of importance Institute of Cell Biology at the University of the universities changes somewhat. Th e of Manitoba is also considered to be a key University of Toronto remains the most institution by interviewees. important, followed by the University of British Columbia, the University of Ottawa, In terms of publications and citations, McGill University, and Université de data from Industry Canada33 showed that Montréal (see Figure 5 above, Table 9 and between 1996 and 2009, Canada published Appendix 4). Th e University of Toronto has over 1,050 regenerative medicine research the most endowed Chairs although there is papers. Overall, Canadian papers in a higher percentage of Chairs as a ratio of regenerative medicine were cited 30% more researchers at many of the other universities oft en than the world average as indicated with more than 10 relevant investigators. On in Table 10 for our key universities: the this measure, Université de Montréal comes University of Toronto, McGill University, fi rst (Table 9). and the University of British Columbia, as well as the University of Alberta, the Within or affi liated with the universities University of Calgary, and McMaster are key research organizations, listed in University. Appendix 4. Th e seven largest of these in terms of numbers of stem cell and regenerative medicine researchers are described in Table 10. Four are affi liated with the University of Toronto (in order of researcher numbers: Ontario Cancer Institute, Sick Kids, McEwen Centre, Sunnybrook) and one of each is affi liated with the University of British Columbia (Terry Fox Laboratory), Université Laval (LOEX), and the University of Ottawa (Sprott Centre). All have endowed Chairs, with the most residing at McEwen (n=6), Sprott (n=5), and Sick Kids (n=4). Table 11 lists 10 other research institutes that each house fi ve or more investigators: three affi liated with the University of British Columbia, two with the University of Toronto, and one each with the University

42 KEY RESEARCHERS AND INSTITUTIONS 8

table 9. Stem Cell and Regenerative Medicine Researchers and Endowed Chairs by University # relevant # relevant endoWed CHairs # puBs/ sCi. ranK BY provinCe universitY researCHers (% of researCHers) iMpaCt * researCHer # alBerta U. Alberta 16 4 (25%) 116/1.7 10

U. Calgary 21 1 (5%) 60/1.6 7 BC SFU 1 0 N/A 21 joint

UBC 50 7 (14%) 121/1.3 2 U. Victoria 2 1 (50%) N/A 19 ManitoBa U. Manitoba 11 2 (18%) N/A 11 neW BrunsWiCK New Brunswick Heart Centre 1 0 N/A 21 joint neWfoundland & laBrador Memorial U. 1 0 N/A 21 joint nova sCotia Dalhousie U. 11 1 (9%) N/A 12 ontario Carleton U. 1 0 N/A 21 joint

McMaster U. 19 5 (26%) 75/1.1 8

Queen’s U. 9 1 (11%) N/A 13 U. Guelph 1 0 N/A 21 joint U. Ottawa 34 9 (26%) N/A 3 U. Toronto 110 24 (22%) 173/1.5 1 U. Waterloo 3 0 N/A 18 U. Western Ontario 17 1 (6%) N/A 9 York U. 1 1 (100%) N/A 20 QuÉBeC École polytechnique de Montréal 7 3 (43%) N/A 14 McGill U. 33 8 (24%) 89/1.1 4 U. Laval 23 1 (4%) N/A 6 U. Montréal 32 10 (31%) N/A 5 U. Québec à Montréal 3 1 (33%) N/A 17

U. Sherbrooke 4 1 (25%) N/A 16 sasKatCHeWan U. Saskatchewan 5 0 N/A 15

43 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE

table 10. Institutions Housing More Than Ten Researchers in Stem Cell and Regenerative Medicine Research universitY researCH institution affiliation Head # res./CHairs* desCription url Ontario Cancer Institute (OCI), UHN [UHN also includes U. Toronto, ON Director OCI: Neel, Benjamin 19/1 Researchers employ state-of-the-art tools in genomics, proteomics, structural biology, molecular biology, www.uhnresearch.ca/ Toronto General Research Institute and Toronto Western biophysics and the behavioural sciences. With these tools they analyze cancerous cells at the molecular institutes/oci Research Institute] level; test gene and cellular therapies for cancer and other diseases; develop new technologies for diagnosing and treating cancer; determine the effects of diet and behaviour on cancer risks; and develop and test informatics tools for the large-scale analysis of patient populations. Hospital for Sick Children (Sick Kids) U. Toronto, ON Chief of Research: Rossant, Janet 16/4 One of the world’s foremost paediatric health-care institutions and Canada’s leading centre dedicated to www.sickkids.ca advancing children’s health through the integration of patient care, research and education. SickKids is one of Canada’s most research-intensive hospitals and has generated discoveries that have helped children globally. Sprott Centre for Stem Cell Research, Ottawa Hospital U. Ottawa, ON Director Sprott: Rudnicki, Michael; 14/5 One of the leading regenerative medicine centres in Canada. Houses the OHRI’s Regenerative Medicine www.ohri.ca/centres/ Research Institute (OHRI) CEO & Sci. Director OHRI: Stewart, Program (which encompasses basic sciences such as stem cell biology, molecular genetics and molecular StemCellResearch/default.asp Duncan biology, and applied sciences such as transplantation and tissue engineering); headquarters for Canada’s Stem Cell Network. Provides an important hub for stem cell research community in Ottawa. McEwen Centre for Regenerative Medicine, Toronto U. Toronto, ON Director McEwan: Keller, Gordon 12/6 Aims to be a world-renowned centre for stem cell biology and regenerative medicine. Working to accelerate www.mcewencentre.com General Research Institute, University Health Network the development of more effective treatments for conditions such as heart disease, diabetes, respiratory (UHN) disease and spinal cord injury. Distributes their stem cells globally. Sunnybrook Research Institute (SRI), Sunnybrook Health U. Toronto, ON 12/1 Main aims are to understand and prevent disease, and develop treatments that enhance and extend life. sunnybrook.ca/research Sciences Centre (SHSC) VP Research SRI: Julius, Michael Main areas of expertise are in clinical epidemiology and health sciences; clinical integrative biology; imaging; and molecular and cellular biology. Terry Fox Research Labs. UBC thru BCCA, Director: Humphries, Keith 10/1 Aims to fuel major improvements in cancer outcomes through basic and translational research with a www.terryfoxlab.ca BC current focus on cancer stem cells. Faculty comprise experts with diverse backgrounds in biology and medicine and internationally recognized leadership in normal and leukemic stem cell investigations, innate and acquired immunity, embryo and tissue development, telomere biology and aging, signalling, genomics, live cell banking, cell separation, imaging and molecular analysis, and bioinformatics and data management. Strategies range from the investigation of model organisms to experiments with patient’s cells and the initiation and laboratory support of clinical trials. LOEX (Experimental Organogenesis Laboratory— U. Laval, QC Director: Auger, François A 10/1 An international leader in tissue engineering. Its strength lies principally in epidermal culture and its self- www.cha.quebec.qc.ca/en/ Laboratoire d’organogénèse expérimentale) Sci. Director: Germain, Lucie assembly approach to tissue engineering. Activities cover four major areas: Stem cells, differentiation www/research/index.html and cellular interactions; Cutaneous, cardiovascular, orthopedic, ophthalmologic, pulmonary and urinary www.loex.qc.ca tissue reconstruction; Biological applications of reconstructed tissues (physiology, pathophysiology, pharmacology, toxicology, transplantation) and pre-clinical trials; Clinical applications of cellular and tissue-based therapies.

*First number is the number of researchers/second number is number of endowed Chairs.

44 KEY RESEARCHERS AND INSTITUTIONS 8

universitY researCH institution affiliation Head # res./CHairs* desCription url Ontario Cancer Institute (OCI), UHN [UHN also includes U. Toronto, ON Director OCI: Neel, Benjamin 19/1 Researchers employ state-of-the-art tools in genomics, proteomics, structural biology, molecular biology, www.uhnresearch.ca/ Toronto General Research Institute and Toronto Western biophysics and the behavioural sciences. With these tools they analyze cancerous cells at the molecular institutes/oci Research Institute] level; test gene and cellular therapies for cancer and other diseases; develop new technologies for diagnosing and treating cancer; determine the effects of diet and behaviour on cancer risks; and develop and test informatics tools for the large-scale analysis of patient populations. Hospital for Sick Children (Sick Kids) U. Toronto, ON Chief of Research: Rossant, Janet 16/4 One of the world’s foremost paediatric health-care institutions and Canada’s leading centre dedicated to www.sickkids.ca advancing children’s health through the integration of patient care, research and education. SickKids is one of Canada’s most research-intensive hospitals and has generated discoveries that have helped children globally. Sprott Centre for Stem Cell Research, Ottawa Hospital U. Ottawa, ON Director Sprott: Rudnicki, Michael; 14/5 One of the leading regenerative medicine centres in Canada. Houses the OHRI’s Regenerative Medicine www.ohri.ca/centres/ Research Institute (OHRI) CEO & Sci. Director OHRI: Stewart, Program (which encompasses basic sciences such as stem cell biology, molecular genetics and molecular StemCellResearch/default.asp Duncan biology, and applied sciences such as transplantation and tissue engineering); headquarters for Canada’s Stem Cell Network. Provides an important hub for stem cell research community in Ottawa. McEwen Centre for Regenerative Medicine, Toronto U. Toronto, ON Director McEwan: Keller, Gordon 12/6 Aims to be a world-renowned centre for stem cell biology and regenerative medicine. Working to accelerate www.mcewencentre.com General Research Institute, University Health Network the development of more effective treatments for conditions such as heart disease, diabetes, respiratory (UHN) disease and spinal cord injury. Distributes their stem cells globally. Sunnybrook Research Institute (SRI), Sunnybrook Health U. Toronto, ON 12/1 Main aims are to understand and prevent disease, and develop treatments that enhance and extend life. sunnybrook.ca/research Sciences Centre (SHSC) VP Research SRI: Julius, Michael Main areas of expertise are in clinical epidemiology and health sciences; clinical integrative biology; imaging; and molecular and cellular biology. Terry Fox Research Labs. UBC thru BCCA, Director: Humphries, Keith 10/1 Aims to fuel major improvements in cancer outcomes through basic and translational research with a www.terryfoxlab.ca BC current focus on cancer stem cells. Faculty comprise experts with diverse backgrounds in biology and medicine and internationally recognized leadership in normal and leukemic stem cell investigations, innate and acquired immunity, embryo and tissue development, telomere biology and aging, signalling, genomics, live cell banking, cell separation, imaging and molecular analysis, and bioinformatics and data management. Strategies range from the investigation of model organisms to experiments with patient’s cells and the initiation and laboratory support of clinical trials. LOEX (Experimental Organogenesis Laboratory— U. Laval, QC Director: Auger, François A 10/1 An international leader in tissue engineering. Its strength lies principally in epidermal culture and its self- www.cha.quebec.qc.ca/en/ Laboratoire d’organogénèse expérimentale) Sci. Director: Germain, Lucie assembly approach to tissue engineering. Activities cover four major areas: Stem cells, differentiation www/research/index.html and cellular interactions; Cutaneous, cardiovascular, orthopedic, ophthalmologic, pulmonary and urinary www.loex.qc.ca tissue reconstruction; Biological applications of reconstructed tissues (physiology, pathophysiology, pharmacology, toxicology, transplantation) and pre-clinical trials; Clinical applications of cellular and tissue-based therapies.

table 11. Research Institutes Housing between Five and Ten Researchers universitY # res./ researCH institute affiliation CHairs * url Samuel Lunenfeld Research Institute, Mount Sinai Hospital U. Toronto, ON 8/3 www.lunenfeld.ca The Donnelly Centre U. Toronto, ON 8/2 thedonnellycentre.utoronto.ca Stem Cell and Cancer Research Institute McMaster U., ON 7/4 sccri.mcmaster.ca Institut de recherches cliniques de Montréal U. Montréal, QC 7/3 ircm.qc.ca Hotchkiss Brain Institute U. Calgary, AB 7/1 www.hbi.ucalgary.ca Vancouver Coastal Health Research Institute UBC, BC 7/0 www.vchri.ca BC Cancer Agency (excl. Terry Fox Laboratory) UBC, BC 6/1 www.bccrc.ca Biomedical Research Centre UBC, BC 6/1 www.brc.ubc.ca Ottawa Hospital Research Institute U. Ottawa, ON 5/1 www.ohri.ca The Research Institute of the McGill University Health McGill U., QC 5/0 muhc.ca Centre *First number is the number of researchers/second number is number of Endowed Chairs.

45 CANADIAN ASSET MAP FOR STEM CELL AND REGENERATIVE MEDICINE

ConClusion In keeping with the fact that Canadian researchers and highest levels of funding. researchers were the fi rst to identify many Researchers’ main area of focus is tissue- types of stem cells, Canada has a signifi cant specifi c stem cells (not embryonic stem cells number of current researchers in this fi eld as may have been assumed), particularly (416 in professor or associate professor hematopoietic, and the most common positions), many of them internationally disease area targeted is cancer. However, renowned. Canada remains among the a number of other disease areas are also world leaders in stem cell research, with important, particularly neurological, Ontario, and the University of Toronto in musculoskeletal, and cardiovascular particular, having the greatest number of conditions.

aCKnoWledgeMents We would like to thank everyone who Cell Research, Ottawa Hospital Research participated in the creation of this Institute; Cindy Bell, Interim Executive document including Eric Cloutier, Policy Director, Cancer Stem Cell Consortium Advisor, Life Science Industries Branch, and Executive VP Corporate Development, Industry Sector, Industry Canada; Genome Canada; Gordon Keller, Canada Sue Kingsley, President, International Research Chair in Embryonic Stem Cell BioPharma Solutions Ltd. (IBPS); Richard Biology, Director, McEwen Centre for Taylor, via IBPS; Helen Kingsley, via IBPS; Regenerative Medicine, University Health Drew Lyall, Executive Director, Canadian Network, University of Toronto; Juan Carlos Stem Cell Network and Board of Directors Zúñiga-Pfl ücker, Director of the Advanced of the Canadian Stem Cell Foundation and Regenerative Tissue Engineering Centre, Canadian Stem Cell Consortium; Michael University of Toronto; Jim Till, President, Rudnicki, Scientifi c Director, Canadian Cancer Stem Cell Consortium and Board Stem Cell Network and Senior Scientist of Directors of the Canadian Stem Cell and Director of the Regenerative Medicine Foundation. Program and the Sprott Centre for Stem

46 ContaCts Industry Canada, Life Science Industries Branch Eric Cloutier 613-941-6479 [email protected] www.ic.gc.ca/lsib

International BioPharma Solutions Ltd. Sue Kingsley 604-408-4310 [email protected] www.BioPharmaSolutions.com

47 appendiX 1 Methodology 2. Using this information, we identifi ed tHis asset Map Was Created as key leaders within the area of Canadian folloWs: regenerative medicine research. We 1. Initial information on regenerative contacted 10 of these individuals by email medicine research in Canada was obtained to ask for an interview or for information. from: Six replied and, using a discussion guide we created for this purpose, we interviewed • Provincial regenerative medicine asset fi ve (listed in Appendix 2) to gain factual maps: information and inform the structure and – Ontario’s MaRS Regenerative Medicine contents of the fi nal report. 2009 Industry Briefi ng report (www.marsdd.com/buzz/reports/ 3. Th e results of the interviews informed regenerativemedicine) some of the other secondary research – Ontario’s MaRS Regenerative Medicine sources we used to obtain information Asset Map 2009 (www.trra.ca/en/ on regenerative medicine researchers and sectors/resources/MRI_asset_maps_ research centres in Canada. Information RM_050809.pdf) was obtained from the websites and – Th e BC Regenerative Medicine Asset reports listed in activity (1), as well as Map (www.tted.gov.bc.ca/MIT/SBIIO/ the following websites, using key word Documents/AssetMap_RegenMed.pdf) searches “stem cells”, “tissue engineering”, and “regenerative”. Data on researchers and • Th e websites of: their projects (as well as their associated – Canada Research Chairs funding, where available) were obtained for (www.chairs-chaires.gc.ca) the past 5 years (2006/7 to 2010/11) and, in – Canadian Stem Cell Network some cases, into the future from: (www.stemcellnetwork.ca) – Canadian Stem Cell Consortium • Canada Foundation for Innovation (www.cancerstemcellconsortium.com) (www.innovation.ca/projects/index.cfm) – Canadian Stem Cell Foundation • Canadian Institutes of Health Research (stemcellfoundation.ca/#/aboutUs) (www.cihr-irsc.gc.ca/e/826.html) • Genome Canada (www.genomecanada. • Industry Canada’s Life Science Industries ca/en/portfolio/project/health. Branch. aspx; www.genomecanada.ca/en/ portfolio/project/technologies.

48 appendiX METHODOLOGY 1

aspx; genomereports.ca/section. 4. Information obtained on researchers php?Lang=En&ID=3&Nav=Section) from all the aforementioned websites • Networks of Centres of Excellence and asset maps was entered into a master (www.nce-rce.gc.ca/NetworksCentres- Excel spreadsheet. Over 2,000 lines of data CentresReseaux/NCE-RCE_eng.asp) were checked for relevance to this project: • National Research Council Canada studentship (undergraduate, Master’s, (www.nrc-cnrc.gc.ca) Doctoral) and postdoctoral fellowship • Natural Sciences and Engineering projects and duplicates were deleted; and Research Council of Canada researchers’ location and activities were (www.outil.ost.uqam.ca/crsng/Outil. checked against their websites to ensure aspx?Langue=Anglais) they worked in the research areas covered • US National Institutes of Health by this Asset Map and were still residents (projectreporter.nih.gov/reporter.cfm) of Canada. Researchers’ specialties were • Terry Fox Foundation (www.tfri.ca/ determined from their funded projects and programs/foundation_programs.asp) websites. International reputation was also • Wellcome Trust (www.wellcome.ac.uk/ considered in terms of endowed research Funding/International/index.htm —no chairs and key accomplishments, with data Canadian projects found) for these being obtained from both CRC • MSFHR (Michael Smith Foundation for and researcher websites, as well as Industry Health Research: www.msfh r.org) Canada. • Alberta Heritage Foundation for Medical Research—Alberta Innovates 5. In terms of funding, dollar amounts (www.ahfmr.ab.ca/experts/search.php) were generally only available from federal • Saskatchewan Health Research databases: CFI, CIHR, NSERC, Genome Foundation (www.shrf.ca) Canada, and NIH. Funding amounts • Manitoba Health Research Council were also available from the Terry (researcherdirectory.mb.ca/eprojects/ Fox Foundation and for some projects prod/mhrc/mhrcdirectory/index.html) supported by the Ontario Ministry of • Ontario Ministry of Research and Research and Innovation and Saskatchewan Innovation (www.mri.gov.on.ca/english/ Health Research Foundation. Th e amount default.asp) of NCE funding was generally gleaned • Fonds de la Recherche en Santé du from press releases. CRC funding was Québec (www.frsq.gouv.qc.ca/en/ calculated according to the number of years recherche_sante/expertise_quebecoise. a researcher had been a CRC at $100,000/yr shtml) for 5 years for a Tier 2 researcher and • Nova Scotia Health Research $200,000/yr for Tier 1 researcher. Such Foundation (www.nshrf.ca/AbsPage. calculations were only conducted if the aspx?siteid=1&lang=1&id=1) CRC funding was not included in the • New Brunswick Health Research NSERC or CIHR information obtained. Foundation (www.nbhrf.com) Where large-scale grants had been • Newfoundland and Labrador Centre for announced before January 2011 but monies Applied Health Research (www.nlcahr. would be released in the future, only funds mun.ca/research/). deemed to have been used up to 2010/11 were included in the analyses. However, it was not always possible to determine when

49 appendiX 1 METHODOLOGY

the money was made available and in those by interviewees and Industry Canada Life cases, funds were assumed to be released Science Industries Branch. within a few months of the announcement. 9. Information on biobank support facilities Although the SCN breaks down its funds was obtained from the existing asset maps for individual research projects, generally and Google searches using key words of only total NCE funding for the Network province or Canada and “cord blood bank”, was used in the analysis as the individual “tissue bank”, “biobank”, or “biorepository”; data were not identifi ed until the end of some information on biobanks was this project. Th e NCE funds were dedicated obtained from www.specimencentral.com/ to the University of Ottawa where the biobank-directory.aspx. Information on SCN is located. NCE funds comprised less other relevant support facilities came from than 10% of total funding so although a existing asset maps and the research on breakdown according to SCN grants across researchers and their facilities. Canada would have made some diﬀ erence to provincial and university funding 10. Information on networks was obtained (Figures 2 and 3), it would probably have from Activity (2) interviews, the websites not been signifi cant except as concerns for the FRSQ (www.frsq.gouv.qc.ca/en/ the University of Ottawa. Even so, this index.shtml), NCE (www.nce-rce.gc.ca/ university would still have ranked among NetworksCentres-CentresReseaux/NCE- the top fi ve. On the other hand, funding for RCE_eng.asp), and Google searches using key researchers (Section 8.1) did include key words of province or Canada plus those granted by the SCN. “research network” or “research group”.

6. Th e data for each relevant researcher were 11. Information on key research centres was categorized according to institution, province, obtained form those centres’ websites. and key research areas. When key research institutes had been identifi ed from this 12. Information on Canada’s global position categorization, the websites of those institutes and expertise was obtained through factual were checked to locate other researchers that data gathered during Activity 2 interviews, may have been missed. information contained in the MaRS Regenerative Medicine 2009 Industry Briefi ng 7. Analyses were conducted in Excel to report, and other publications as shown in determine researcher numbers, expertise, Appendix 5. and government funding according to province and institution; and key researchers according to the amount of funding obtained.

8. For general information on stem cells/ regenerative medicine and Canada’s position in stem research we used the sources listed in Appendix 5, some of which were provided

50 appendiX INTERVIEWEES 2

2 Interviewees 1. Bell, Cindy. Interim Executive Director, 5. Zúñiga-P ücker, Juan Carlos. Director Cancer Stem Cell Consortium and of the Advanced Regenerative Tissue Executive VP Corporate Development, Engineering Centre, University of Toronto. Genome Canada. [email protected]; (www.sunnybrook.ca/research/team/ T: 613-751-4460. Interviewed December 21, member.asp?t=13&m=191&page=1100) 2010. [email protected]; T: 416-480-6112. Interviewed Dec 16, 2010. 2. Keller, Gordon. Canada Research Chair in Embryonic Stem Cell Biology, Director, McEwen Centre for Regenerative Medicine, University Health Network, University of Toronto. (www.uhnres.utoronto.ca/ researchers/profi le.php?lookup=12091. medbio.utoronto.ca/faculty/keller.html. www.trra.ca/en/profi les/gkeller.asp). [email protected]; T: 416-581-7694. Interviewed Dec 23, 2010.

3. Lyall, Drew (Andrew). Executive Director, Canadian Stem Cell Network and Board of Directors of the Canadian Stem Cell Foundation and Canadian Stem Cell Consortium. (www.stemcellnetwork.ca/ index.php?page=network-staﬀ &hl=eng). [email protected]; T: 613-739-6675. Interviewed Dec 17, 2010.

4. Rudnicki, Michael. Scientifi c Director, Canadian Stem Cell Network Senior Scientist and Director of the Regenerative Medicine Program and the Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute. (www.ohri.ca/profi les/rudnicki.asp). [email protected]; T: 613-739-6740. Interviewed Dec 20, 2010.

51 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3a. Researchers in Alphabetical Order universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Acker, Jason U. Alberta AB Tissue engineering— Various No lmp.med.ualberta.ca/Admin/Faculty/Pages/default. [email protected] cell storage aspx?P=13 Akimenko, Marie-Andrée Ottawa Hospital Research Institute U. Ottawa ON Regeneration—tissue Musculoskeletal No www.careg.uottawa.ca/bio_marie_andree_ [email protected] akimenko.htm Allan, Alison London Regional Cancer Program, U. Western ON Stem cells—cancer Cancer—breast No www.uwo.ca/anatomy/department/allana/aallan.html [email protected] London Health Sciences Centre Ontario Allan, David Sprott Centre for Stem Cell Research, U. Ottawa ON Stem cells— Cardiovascular No www.ohri.ca/profi les/allan.asp [email protected] Ottawa Health Research Institute hematopoietic Alman, Benjamin Hospital for Sick Children U. Toronto ON Stem cells— Musculoskeletal CRC in Mus- www.sickkids.ca/AboutSickKids/Directory/People/A/ [email protected] mesenchymal culoskeletal Benjamin-Alman-Staff-Profi le.html Research; A.J. Latner Profes- sor and Chair of Orthopaedic Surgery Amsden, Brian Queens U. ON Tissue engineering— Various No chemeng.queensu.ca/people/faculty/amsden/ [email protected] scaffolds Anderson, Colin C. U. Alberta AB Stem cells— Metabolic—diabetes No www.ualberta.ca/~smri/Surgery Research Web [email protected] pancreatic (islet) Page/DrAnderson.htm Anderson, Michele Sunnybrook Research Institute U. Toronto ON Stem cells— Cancer—leukemia, No www.immunology.utoronto.ca/faculty/directory/ [email protected] hematopoietic lymphoma anderson.htm Annabi, Borhane U. Québec à QC Stem cells— Cancer CRC in Molecular borhaneannabi.net/index.php?option=com_content& [email protected] Montréal unspecifi ed Oncology view=section&layout=blog&id=2&Itemid=2 Antel, Jack McGill U. QC Stem cells—adult Neurological—multiple No www.mni.mcgill.ca/neuro_team/cru/jack_antel/ [email protected] sclerosis Antoniou, John Jewish General Hospital McGill U. QC Tissue engineering— Musculoskeletal No orthodoc.aaos.org/antoniou/ [email protected] scaffold; Stem cells— mesenchymal Aparicio, Samuel BC Cancer Agency U. British BC Stem cells—various— Cancer—breast CRC in Molecular www.pathology.ubc.ca/NewPathology/Professor/ [email protected] Columbia hematopoietic, induced Oncology; Nan Samuel_Aparicio.html pluripotent and Lorraine Robertson Chair Arora, Rakesh C. Associated with National Research U. Manitoba MB Stem cells—fat Cardiology No www.sbrc.ca/content/blogcategory/59/93/ [email protected] Council of Canada, Institute for Biological Sciences Atkins, Harry Sprott Centre for Stem Cell Research, U. Ottawa ON Stem cells— Various, incl. cancer— No www.ohri.ca/profi les/atkins.asp [email protected] Ottawa Health Research Institute hematopoietic hematopoietic, neurological—MS Aubin, Jane U. Toronto ON Stem cells— Musculoskeletal No medbio.utoronto.ca/faculty/aubin.html [email protected] mesenchymal Audet, Julie Institute of Biomaterials and U. Toronto ON Stem cells— Various No individual.utoronto.ca/julie_audet/ [email protected] Biomedical Engineering hematopoietic Auger, François A. LOEX U. Laval QC Tissue engineering— Various, incl. No www.loex.qc.ca/chercheurs.cv.php?id=2 [email protected] cell culture cardiovascular, transplantation, injury Bader, Gary Institute of Biomaterials and U. Toronto ON Stem cells—embryonic Various No www.lunenfeld.ca/researchers/bader [email protected] Biomedical Engineering

52 appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER 3

universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Acker, Jason U. Alberta AB Tissue engineering— Various No lmp.med.ualberta.ca/Admin/Faculty/Pages/default. [email protected] cell storage aspx?P=13 Akimenko, Marie-Andrée Ottawa Hospital Research Institute U. Ottawa ON Regeneration—tissue Musculoskeletal No www.careg.uottawa.ca/bio_marie_andree_ [email protected] akimenko.htm Allan, Alison London Regional Cancer Program, U. Western ON Stem cells—cancer Cancer—breast No www.uwo.ca/anatomy/department/allana/aallan.html [email protected] London Health Sciences Centre Ontario Allan, David Sprott Centre for Stem Cell Research, U. Ottawa ON Stem cells— Cardiovascular No www.ohri.ca/profi les/allan.asp [email protected] Ottawa Health Research Institute hematopoietic Alman, Benjamin Hospital for Sick Children U. Toronto ON Stem cells— Musculoskeletal CRC in Mus- www.sickkids.ca/AboutSickKids/Directory/People/A/ [email protected] mesenchymal culoskeletal Benjamin-Alman-Staff-Profi le.html Research; A.J. Latner Profes- sor and Chair of Orthopaedic Surgery Amsden, Brian Queens U. ON Tissue engineering— Various No chemeng.queensu.ca/people/faculty/amsden/ [email protected] scaffolds Anderson, Colin C. U. Alberta AB Stem cells— Metabolic—diabetes No www.ualberta.ca/~smri/Surgery Research Web [email protected] pancreatic (islet) Page/DrAnderson.htm Anderson, Michele Sunnybrook Research Institute U. Toronto ON Stem cells— Cancer—leukemia, No www.immunology.utoronto.ca/faculty/directory/ [email protected] hematopoietic lymphoma anderson.htm Annabi, Borhane U. Québec à QC Stem cells— Cancer CRC in Molecular borhaneannabi.net/index.php?option=com_content& [email protected] Montréal unspecifi ed Oncology view=section&layout=blog&id=2&Itemid=2 Antel, Jack McGill U. QC Stem cells—adult Neurological—multiple No www.mni.mcgill.ca/neuro_team/cru/jack_antel/ [email protected] sclerosis Antoniou, John Jewish General Hospital McGill U. QC Tissue engineering— Musculoskeletal No orthodoc.aaos.org/antoniou/ [email protected] scaffold; Stem cells— mesenchymal Aparicio, Samuel BC Cancer Agency U. British BC Stem cells—various— Cancer—breast CRC in Molecular www.pathology.ubc.ca/NewPathology/Professor/ [email protected] Columbia hematopoietic, induced Oncology; Nan Samuel_Aparicio.html pluripotent and Lorraine Robertson Chair Arora, Rakesh C. Associated with National Research U. Manitoba MB Stem cells—fat Cardiology No www.sbrc.ca/content/blogcategory/59/93/ [email protected] Council of Canada, Institute for Biological Sciences Atkins, Harry Sprott Centre for Stem Cell Research, U. Ottawa ON Stem cells— Various, incl. cancer— No www.ohri.ca/profi les/atkins.asp [email protected] Ottawa Health Research Institute hematopoietic hematopoietic, neurological—MS Aubin, Jane U. Toronto ON Stem cells— Musculoskeletal No medbio.utoronto.ca/faculty/aubin.html [email protected] mesenchymal Audet, Julie Institute of Biomaterials and U. Toronto ON Stem cells— Various No individual.utoronto.ca/julie_audet/ [email protected] Biomedical Engineering hematopoietic Auger, François A. LOEX U. Laval QC Tissue engineering— Various, incl. No www.loex.qc.ca/chercheurs.cv.php?id=2 [email protected] cell culture cardiovascular, transplantation, injury Bader, Gary Institute of Biomaterials and U. Toronto ON Stem cells—embryonic Various No www.lunenfeld.ca/researchers/bader [email protected] Biomedical Engineering

53 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3a. Cont’d

universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Bani, Mahmud Associated with National Research U. Ottawa ON Stem cells—adult Neurological—brain No www.med.uottawa.ca/NSC/eng/dr_mahmud_bani. [email protected] Council of Canada, Institute for injury html Biological Sciences Barabé, Frédéric U. Laval QC Stem cells— Cancer—leukemia No www.cri.ulaval.ca/?fbarabe_eng [email protected] hematopoietic Barber, Dwayne Ontario Cancer Institute, University U. Toronto ON Stem cells— Hematological— No www.uhnres.utoronto.ca/researchers/profi le. [email protected] Health Network hematopoietic anemia, cancer php?lookup=335 Barralet, Jake McGill U. QC Biomaterials Musculoskeletal— CRC in in www.mcgill.ca/dentistry/research/barralet/ [email protected] bone formation Osteoinductive Biomaterials Barrett, Christopher McGill U. QC Biomaterials Various No www.chemistry.mcgill.ca/directory/people. [email protected] php?p=9&n=Barrett&t=materials Baylis, Françoise Dalhousie U. NS Social science & SSH: Ethics CRC in Bioethics bioethics.medicine.dal.ca/people/fbaylis.php [email protected] humanities & Philosophy Beausejour, Christian Hôpital Sainte-Justine (Montréal) U. Montréal QC Stem cells— Cancer No www.chu-sainte-justine.org/research/chercheurs. christian.beausejour@recherche-ste- hematopoietic aspx?id_nouveau=65947859&id_page=2432&id_ justine.qc.ca menu=2429 Behie, Leo Includes: Pharmaceutical Production U. Calgary AB Bioprocessing—stem Various—neurological, CRC in schulich.ucalgary.ca/resrch_chem/Chem_Behie.htm [email protected] Research Facility cells production/ metabolic-diabetes Biomedical and culture Biochemical Engineering Ben-David, Yaacov Sunnybrook Research Institute U. Toronto ON Stem cells— Cancer—leukemia No medbio.utoronto.ca/faculty/bendavid.html [email protected] hematopoietic Bennett, Steffany U. Ottawa ON Stem cells—neural Neurological, incl. No www.med.uottawa.ca/bmi/eng/bennett.html [email protected] Alzheimer’s Berthod, François LOEX U. Laval QC Tissue engineering— Various, incl. No www.cha.quebec.qc.ca/en/www/research/the- [email protected] stem cells neurological, research-centre/researchers/francois-berthod/index. urological, cutaneous html Betts, Dean U. Western ON Stem cells— Various No www.uwo.ca/physpharm/facultyprofi le/betts.html [email protected] Ontario pluripotent— induced pluripotent Bhatia, Mickie Stem Cell and Cancer Research McMaster U. ON Stem cells—various— Various, incl. CRC in Human sccri.mcmaster.ca/bhatia_mick.html [email protected] Institute pluripotent, embryonic, respiratory—lung Stem Cell hematopoietic disease Biology; Krembil Chair in Stem Cell Biology Biernaskie, Jeffrey A. Associated with Hotchkiss Brain U. Calgary AB Stem cells—dermal Neurological—injury, No www.ucalgary.ca/research4kids/members/ [email protected] Institute wound healing biernaskie_full Bijl, Janetta U. Montréal QC Stem cells— Cancer—leukemia No recherche.maisonneuve-rosemont.org/en-ca/ [email protected] hematopoietic research/our-research-investigators/bijl-janet.html Bjerknes, Matthew J. U. Toronto ON Stem cells— Gastrointestinal No medbio.utoronto.ca/faculty/bjerknes.html [email protected] gastrointestinal Bramson, Jonathan McMaster U. ON Stem cells—cancer Cancer No fhs.mcmaster.ca/cgt/bramson_jonathan.html [email protected]

Brand, Marjorie Sprott Centre for Stem Cell Research, U. Ottawa ON Stem cells— Hematological—ß- CRC in the www.ohri.ca/profi les/brand.asp [email protected] Ottawa Health Research Institute hematopoietic thalassemia and sickle Regulation of cell anemia Gene Expression Brash, John McMaster U. ON Biomaterials Various No chemeng.mcmaster.ca/brash.html [email protected]

54 appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER 3

55 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3a. Cont’d universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Brinkman, Ryan Terry Fox Laboratory, BC Cancer U. British BC Stem cells—cancer Cancer No www.terryfoxlab.ca/people/RBrinkman/ryan.aspx [email protected] Agency Columbia Brodt, Pnina The Research Institute of the McGill McGill U. QC Stem cells—adult— Cancer No www.mcgill.ca/translational-research-cancer/ [email protected] University Health Centre stromal researcher-biographies/brodt/ Brunette, Donald Biomedical Research Centre U. British BC Tissue engineering— Musculoskeletal No www.dentistry.ubc.ca/research/brunette.html [email protected] Columbia biomaterials, stem cells—mesenchymal Bubela, Tania U. Alberta AB Social science & SSH: Socioeconomic No www.publichealth.ualberta.ca/en/research/ [email protected] humanities benefi ts researchers_supersivors/faculty/bubela.aspx Burt, Helen Mary Biomedical Research Centre U. British BC Tissue engineering— Musculoskeletal No https://www.directory.ubc.ca/index.cfm?page=perso [email protected] Columbia biomaterials, stem nDetail&row=104080471 cells—mesenchymal Buschmann, Michael École QC Biomaterials Musculoskeletal— CRC in www.groupes.polymtl.ca/tissue/en/staff/buschmann. [email protected] polytechnique de cartilage cell delivery Cartilage Tissue php Montréal Engineering Calderone, Angelo Montreal Heart Institute U. Montréal QC Stem cells—neural Cardiology No www.recherche.umontreal.ca/chercheurs_unites/ [email protected] chercheur_affi chage.asp?noseq_chercheur=1596 Cao, Xudong U. Ottawa ON Biomaterials; Tissue Neurological—spinal No www.engineering.uottawa.ca/en/directory/view/ [email protected] engineering—stem cord, eye xudong_cao/ cells Carreau, Madeleine Centre hospitalier de l’Université Laval U. Laval QC Stem cells— Hematological— No www.crchuq.ulaval.ca/en/research/researchers/8076 [email protected] hematopoietic anemia Carrier, Patrick LOEX U. Laval QC Stem cells—epithelial Eye No www.cha.quebec.qc.ca/en/www/research/the- [email protected] (from cornea) research-centre/researchers/patrick-carrier/index. html Casper, Robert Samuel Lunenfeld Research Institute, U. Toronto ON Stem cells— Reproduction—female No www.obgyn.utoronto.ca/faculty/list/All-Faculty/ [email protected] Mount Sinai Hospital hematopoietic fertility Casper.htm Catelas, Isabelle U. Ottawa ON Tissue engineering Musculoskeletal— CRC in www.engineering.uottawa.ca/en/directory/view/ [email protected] bone loss Bioengineering in catelas_isabelle/ Orthopedics Caulfi eld, Tim U. Alberta AB Social science & SSH: Ethics and law CRC in Health www.law.ualberta.ca/facultystaff/profi les/caulfi eld. tcaulfl [email protected] humanities Law and Policy php Cayouette, Michel Institut de recherches cliniques de U. Montréal QC Stem cells—neural Neurological, including No www.cenum.umontreal.ca/membres/2_titulaires/ [email protected] Montréal eye en_cayouette_m.html Chandler, Jennifer U. Ottawa ON Social science & SSH: Law, policy No www.commonlaw.uottawa.ca/en/jennifer-chandler. [email protected] humanities html Chang, Thomas Ming Swi Artifi cial Cells and Organs Research McGill U. QC Tissue engineering— Various, incl. No www.medicine.mcgill.ca/artcell/ [email protected] Centre artifi cial blood cells cardiovascular www.labome.org/expert/canada/mcgill/chang/ thomas-ming-swi-chang-253343.html Chen, Daniel (Xiongbiao) U. Saskatchewan Sask Tissue engineering— Neurological— No www.engr.usask.ca/faculty/Chen_Daniel.php [email protected] scaffolds peripheral Chen, Jie U. Alberta AB Stem cells—cord Various No www.ece.engineering.ualberta.ca/en/FacultyStaff/ [email protected] blood FacultyAcademic/JieChen.aspx Cheng, Hai-Ling Margaret Sunnybrook Research Institute U. Toronto ON Stem cells— Neurological—stroke No www.sickkids.ca/AboutSickKids/Directory/People/C/ [email protected] unspecifi ed Hai-Ling-Margaret-Cheng-Staff-Profi le.html Chow, Bob U. Victoria BC Stem cells—retinal Eye CRC in Retinal web.uvic.ca/biology/faculty/facpages/chow.html [email protected] and Early Eye Development 56 appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER 3

universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Brinkman, Ryan Terry Fox Laboratory, BC Cancer U. British BC Stem cells—cancer Cancer No www.terryfoxlab.ca/people/RBrinkman/ryan.aspx [email protected] Agency Columbia Brodt, Pnina The Research Institute of the McGill McGill U. QC Stem cells—adult— Cancer No www.mcgill.ca/translational-research-cancer/ [email protected] University Health Centre stromal researcher-biographies/brodt/ Brunette, Donald Biomedical Research Centre U. British BC Tissue engineering— Musculoskeletal No www.dentistry.ubc.ca/research/brunette.html [email protected] Columbia biomaterials, stem cells—mesenchymal Bubela, Tania U. Alberta AB Social science & SSH: Socioeconomic No www.publichealth.ualberta.ca/en/research/ [email protected] humanities benefi ts researchers_supersivors/faculty/bubela.aspx Burt, Helen Mary Biomedical Research Centre U. British BC Tissue engineering— Musculoskeletal No https://www.directory.ubc.ca/index.cfm?page=perso [email protected] Columbia biomaterials, stem nDetail&row=104080471 cells—mesenchymal Buschmann, Michael École QC Biomaterials Musculoskeletal— CRC in www.groupes.polymtl.ca/tissue/en/staff/buschmann. [email protected] polytechnique de cartilage cell delivery Cartilage Tissue php Montréal Engineering Calderone, Angelo Montreal Heart Institute U. Montréal QC Stem cells—neural Cardiology No www.recherche.umontreal.ca/chercheurs_unites/ [email protected] chercheur_affi chage.asp?noseq_chercheur=1596 Cao, Xudong U. Ottawa ON Biomaterials; Tissue Neurological—spinal No www.engineering.uottawa.ca/en/directory/view/ [email protected] engineering—stem cord, eye xudong_cao/ cells Carreau, Madeleine Centre hospitalier de l’Université Laval U. Laval QC Stem cells— Hematological— No www.crchuq.ulaval.ca/en/research/researchers/8076 [email protected] hematopoietic anemia Carrier, Patrick LOEX U. Laval QC Stem cells—epithelial Eye No www.cha.quebec.qc.ca/en/www/research/the- [email protected] (from cornea) research-centre/researchers/patrick-carrier/index. html Casper, Robert Samuel Lunenfeld Research Institute, U. Toronto ON Stem cells— Reproduction—female No www.obgyn.utoronto.ca/faculty/list/All-Faculty/ [email protected] Mount Sinai Hospital hematopoietic fertility Casper.htm Catelas, Isabelle U. Ottawa ON Tissue engineering Musculoskeletal— CRC in www.engineering.uottawa.ca/en/directory/view/ [email protected] bone loss Bioengineering in catelas_isabelle/ Orthopedics Caulfi eld, Tim U. Alberta AB Social science & SSH: Ethics and law CRC in Health www.law.ualberta.ca/facultystaff/profi les/caulfi eld. tcaulfl [email protected] humanities Law and Policy php Cayouette, Michel Institut de recherches cliniques de U. Montréal QC Stem cells—neural Neurological, including No www.cenum.umontreal.ca/membres/2_titulaires/ [email protected] Montréal eye en_cayouette_m.html Chandler, Jennifer U. Ottawa ON Social science & SSH: Law, policy No www.commonlaw.uottawa.ca/en/jennifer-chandler. [email protected] humanities html Chang, Thomas Ming Swi Artifi cial Cells and Organs Research McGill U. QC Tissue engineering— Various, incl. No www.medicine.mcgill.ca/artcell/ [email protected] Centre artifi cial blood cells cardiovascular www.labome.org/expert/canada/mcgill/chang/ thomas-ming-swi-chang-253343.html Chen, Daniel (Xiongbiao) U. Saskatchewan Sask Tissue engineering— Neurological— No www.engr.usask.ca/faculty/Chen_Daniel.php [email protected] scaffolds peripheral Chen, Jie U. Alberta AB Stem cells—cord Various No www.ece.engineering.ualberta.ca/en/FacultyStaff/ [email protected] blood FacultyAcademic/JieChen.aspx Cheng, Hai-Ling Margaret Sunnybrook Research Institute U. Toronto ON Stem cells— Neurological—stroke No www.sickkids.ca/AboutSickKids/Directory/People/C/ [email protected] unspecifi ed Hai-Ling-Margaret-Cheng-Staff-Profi le.html Chow, Bob U. Victoria BC Stem cells—retinal Eye CRC in Retinal web.uvic.ca/biology/faculty/facpages/chow.html [email protected] and Early Eye Development 57 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3a. Cont’d universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Couban, Stephen Dalhousie U. NS Stem cells—cord Cancer— No dom.medicine.dal.ca/clinicaldivisions/hematology/ [email protected] blood hematological faculty.htm Courtman, David Sprott Centre for Stem Cell Research, U. Ottawa ON Stem cells—adult— Cardiopulmonary No www.ohri.ca/profi les/courtman.asp [email protected] Ottawa Hospital Research Institute endothelial progenitor Cregan, Sean John P. Robarts Research Institute U. Western ON Stem cells—neural Neurological CRC in Neurode- www.uwo.ca/physpharm/faculty/cregan_sean.html [email protected] Ontario generation and Stem Cell Regen- eration Cross, James Charles U. Calgary AB Stem cells— Reproduction—female No people.ucalgary.ca/~jcross/homepage.html [email protected] various—embryonic, trophoblast, placental, germline Crump, Michael A. Ontario Cancer Institute, University U. Toronto ON Stem cells— Cancer—lymphoma No www.uhnresearch.ca/researchers/profi le. [email protected] Health Network hematopoietic php?lookup=1254 Daar, Abdallah McLaughlin-Rotman Centre for Global U. Toronto ON Social science & SSH: Ethics and law No www.uhnresearch.ca/researchers/profi le. [email protected] Health, University Health Network humanities php?lookup=18592 Dankort, David McGill U. QC Stem cells—cancer Cancer No biology.mcgill.ca/faculty/dankort/index.html [email protected]

Davies, John U. Toronto ON Tissue engineering— Musculoskeletal— No www.utoronto.ca/dentistry/facultyresearch/ [email protected] scaffolds; Stem cells— bone facultyprofi les/john_davies.html mesenchymal De Crescenzo, Gregory École QC Biomaterials Various— CRC in Protein- www.polymtl.ca/recherche/rc/en/professeurs/ [email protected] polytechnique de musculoskeletal, Enhanced details.php?NoProf=302 Montréal cardiovascular Biomaterials DeCoteau, John U. Saskatchewan Sask Stem cells—cancer Cancer No www.medicine.usask.ca/pathology/people/faculty/ [email protected] dr-j-decoteau/ Dedhar, Shoukat BC Cancer Agency U. British BC Stem cells—mammary Cancer No www.bccrc.ca/dept/ic/genetics/shoukat-dedhar-phd [email protected] Columbia Dekaban, Gregory John P. Robarts Research Institute U. Western ON Stem cells— Neurological—spinal No www.robarts.ca/biotherapeutics/Dekaban.htm [email protected] Ontario unspecifi ed cord injury Denburg, Judah Aryeh McMaster U. ON Stem cells— Immunological— No fhs.mcmaster.ca/medicine/Immunology_Allergy/ [email protected] hematopoietic allergy, asthma faculty_member_denburg.htm Dennis, James W. Samuel Lunenfeld Research Institute, U. Toronto ON Stem cells— Cancer, other CRC in www.lunenfeld.ca/researchers/dennis [email protected] Mount Sinai Hospital unspecifi ed Glycobiology Dick, Alexander Sunnybrook Research Institute U. Toronto ON Stem cells— Cardiology No sunnybrook.ca/research/team/member. [email protected] mesenchymal asp?t=10&m=53&page=172 Dick, John McEwen Centre for Regenerative U. Toronto ON Stem cells—various, Cancer, incl. leukemia CRC in Stem Cell www.uhnres.utoronto.ca/researchers/profi le. [email protected] Medicine and Ontario Cancer incl. hematopoietic Biology php?lookup=1468 Institute, University Health Network Dilworth, Jeffrey Sprott Centre for Stem Cell Research, U. Ottawa ON Stem cells—muscle Musculoskeletal: CRC in Epigenetic www.ohri.ca/profi les/dilworth.asp [email protected] Ottawa Health Research Institute progenitors Duchenne Regulation of Transcription Dirks, Peter Hospital for Sick Children U. Toronto ON Stem cells—neural Cancer—brain No www.sickkids.ca/AboutSickKids/Directory/People/D/ [email protected] Peter-Dirks.html Doble, Bradley Stem Cell and Cancer Research McMaster U. ON Stem cells—embryonic Cancer CRC in Stem Cell www.fhs.mcmaster.ca/SCCRI/faculty/doble.html [email protected] Institute Signaling Dobrinski, Ina U. Calgary AB Stem cells— Reproduction—male No www.ucalgary.ca/bmb/dobrinski [email protected] germline—testis

58 appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER 3

universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Couban, Stephen Dalhousie U. NS Stem cells—cord Cancer— No dom.medicine.dal.ca/clinicaldivisions/hematology/ [email protected] blood hematological faculty.htm Courtman, David Sprott Centre for Stem Cell Research, U. Ottawa ON Stem cells—adult— Cardiopulmonary No www.ohri.ca/profi les/courtman.asp [email protected] Ottawa Hospital Research Institute endothelial progenitor Cregan, Sean John P. Robarts Research Institute U. Western ON Stem cells—neural Neurological CRC in Neurode- www.uwo.ca/physpharm/faculty/cregan_sean.html [email protected] Ontario generation and Stem Cell Regen- eration Cross, James Charles U. Calgary AB Stem cells— Reproduction—female No people.ucalgary.ca/~jcross/homepage.html [email protected] various—embryonic, trophoblast, placental, germline Crump, Michael A. Ontario Cancer Institute, University U. Toronto ON Stem cells— Cancer—lymphoma No www.uhnresearch.ca/researchers/profi le. [email protected] Health Network hematopoietic php?lookup=1254 Daar, Abdallah McLaughlin-Rotman Centre for Global U. Toronto ON Social science & SSH: Ethics and law No www.uhnresearch.ca/researchers/profi le. [email protected] Health, University Health Network humanities php?lookup=18592 Dankort, David McGill U. QC Stem cells—cancer Cancer No biology.mcgill.ca/faculty/dankort/index.html [email protected]

59 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3a. Cont’d universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Doillon, Charles U. Laval QC Tissue engineering— Various— No www.crchuq.ulaval.ca/en/research/researchers/4683 [email protected] biomaterials cardiovascular, cancer Downey, Gregory U. Toronto ON Regenerative Respiratory CRC in www.utoronto.ca/respirology/who/Gregory_Downey. [email protected] medicine—unspecifi ed Respiration html Sciences Doyle, John U. Toronto ON Stem cells— Cancer No www.paeds.utoronto.ca/faculty/doyle.htm [email protected] hematopoietic Draper, Jonathan Stem Cell and Cancer Research McMaster U. ON Stem cells—embryonic Various CRC in Human sccri.mcmaster.ca/draper_jon.html [email protected] Institute Stem Cell Lineage Commitment Drouin, Jacques Institut de recherches cliniques de U. Montréal QC Stem cells—fetal Neurological— GlaxoSmithKline www.ircm.qc.ca/en/recherche/statique/unite27.html [email protected] Montréal Parkinson’s Chair in Molecular Genetics Duff, Henry Joseph U. Calgary AB Stem cells— Cardiology No cardiacsciences.ucalgary.ca/research/#duff [email protected] unspecifi ed Dufort, Daniel McGill U. QC Stem cells—embryonic Reproduction— No www.medicine.mcgill.ca/expmed/staff/dufort_daniel. [email protected] implantation htm Dumont, Dan Sunnybrook Research Institute U. Toronto ON Stem cells—embryonic Various— No medbio.utoronto.ca/faculty/dumont.html [email protected] cardiovascular, cancer Duval, Michel U. Montréal QC Stem cells—cord Various No www.chu-sainte-justine.org/research/chercheurs. [email protected] blood aspx?ID_nouveau=38393948&id_page=2432&id_ menu=2429 Dyck, Richard Henry Associated with Hotchkiss Brain U. Calgary AB Stem cells— Neurological—brain No www.cell.ucalgary.ca/r_dyck.html [email protected] Institute unspecifi ed Eaves, Allen Terry Fox Laboratory, BC Cancer U. British BC Stem cells— Cancer—leukemia No www.bccrc.ca/dept/terry-fox-laboratory/faculty/dr.- [email protected] Agency Columbia hematopoietic allen-eaves Eaves, Connie Terry Fox Laboratory, BC Cancer U. British BC Stem cells—various Cancer No www.bccrc.ca/dept/terry-fox-laboratory/faculty/dr.- [email protected] Agency Columbia (embryonic, connie-eaves hematopoietic, breast epithelial) Egan, Sean Hospital for Sick Children U. Toronto ON Stem cells—mammary Cancer—breast No www.sickkids.ca/AboutSickKids/Directory/People/E/ [email protected] epithelial Sean-Egan.html Einsiedel, Edna U. Calgary AB Social science & SSH: Social science No www.ucalgary.ca/einsiedel/ [email protected] humanities El-Hakim, Assaad McGill U. QC Tissue engineering— Urological No urology.mcgill.ca/clinicalStaff/associatePart/El- [email protected] biomaterials, cells Hakim_A.html Eliopoulos, Nicoletta Jewish General Hospital, Lady Davis McGill U. QC Stem cells— Renal No www.ladydavis.ca/en/nicolettaeliopoulos [email protected] Institute for Medical Research mesenchymal Elliott, Janet Anne Wade U. Alberta AB Technology— Various CRC in Interfacial www.cme.engineering.ualberta.ca/en/FacultyStaff/ [email protected] stem cells— Thermodynamics FacultyAcademicStaff/Elliott.aspx cryopreservation Ellis, Anne Queen’s U. ON Stem cells— Immunological— No microimm.queensu.ca/facultyPages/cross_ [email protected] hematopoietic (cord allergy appointed/ellis.html blood) Ellis, James Hospital for Sick Children U. Toronto ON Stem cells— Various, incl. No www.sickkids.ca/Research/Ellis-Lab/index.html [email protected] pluripotent— neurological, incl. embryonic, induced Rett’s; hematological— pluripotent anemia 60 appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER 3

universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Doillon, Charles U. Laval QC Tissue engineering— Various— No www.crchuq.ulaval.ca/en/research/researchers/4683 [email protected] biomaterials cardiovascular, cancer Downey, Gregory U. Toronto ON Regenerative Respiratory CRC in www.utoronto.ca/respirology/who/Gregory_Downey. [email protected] medicine—unspecifi ed Respiration html Sciences Doyle, John U. Toronto ON Stem cells— Cancer No www.paeds.utoronto.ca/faculty/doyle.htm [email protected] hematopoietic Draper, Jonathan Stem Cell and Cancer Research McMaster U. ON Stem cells—embryonic Various CRC in Human sccri.mcmaster.ca/draper_jon.html [email protected] Institute Stem Cell Lineage Commitment Drouin, Jacques Institut de recherches cliniques de U. Montréal QC Stem cells—fetal Neurological— GlaxoSmithKline www.ircm.qc.ca/en/recherche/statique/unite27.html [email protected] Montréal Parkinson’s Chair in Molecular Genetics Duff, Henry Joseph U. Calgary AB Stem cells— Cardiology No cardiacsciences.ucalgary.ca/research/#duff [email protected] unspecifi ed Dufort, Daniel McGill U. QC Stem cells—embryonic Reproduction— No www.medicine.mcgill.ca/expmed/staff/dufort_daniel. [email protected] implantation htm Dumont, Dan Sunnybrook Research Institute U. Toronto ON Stem cells—embryonic Various— No medbio.utoronto.ca/faculty/dumont.html [email protected] cardiovascular, cancer Duval, Michel U. Montréal QC Stem cells—cord Various No www.chu-sainte-justine.org/research/chercheurs. [email protected] blood aspx?ID_nouveau=38393948&id_page=2432&id_ menu=2429 Dyck, Richard Henry Associated with Hotchkiss Brain U. Calgary AB Stem cells— Neurological—brain No www.cell.ucalgary.ca/r_dyck.html [email protected] Institute unspecifi ed Eaves, Allen Terry Fox Laboratory, BC Cancer U. British BC Stem cells— Cancer—leukemia No www.bccrc.ca/dept/terry-fox-laboratory/faculty/dr.- [email protected] Agency Columbia hematopoietic allen-eaves Eaves, Connie Terry Fox Laboratory, BC Cancer U. British BC Stem cells—various Cancer No www.bccrc.ca/dept/terry-fox-laboratory/faculty/dr.- [email protected] Agency Columbia (embryonic, connie-eaves hematopoietic, breast epithelial) Egan, Sean Hospital for Sick Children U. Toronto ON Stem cells—mammary Cancer—breast No www.sickkids.ca/AboutSickKids/Directory/People/E/ [email protected] epithelial Sean-Egan.html Einsiedel, Edna U. Calgary AB Social science & SSH: Social science No www.ucalgary.ca/einsiedel/ [email protected] humanities El-Hakim, Assaad McGill U. QC Tissue engineering— Urological No urology.mcgill.ca/clinicalStaff/associatePart/El- [email protected] biomaterials, cells Hakim_A.html Eliopoulos, Nicoletta Jewish General Hospital, Lady Davis McGill U. QC Stem cells— Renal No www.ladydavis.ca/en/nicolettaeliopoulos [email protected] Institute for Medical Research mesenchymal Elliott, Janet Anne Wade U. Alberta AB Technology— Various CRC in Interfacial www.cme.engineering.ualberta.ca/en/FacultyStaff/ [email protected] stem cells— Thermodynamics FacultyAcademicStaff/Elliott.aspx cryopreservation Ellis, Anne Queen’s U. ON Stem cells— Immunological— No microimm.queensu.ca/facultyPages/cross_ [email protected] hematopoietic (cord allergy appointed/ellis.html blood) Ellis, James Hospital for Sick Children U. Toronto ON Stem cells— Various, incl. No www.sickkids.ca/Research/Ellis-Lab/index.html [email protected] pluripotent— neurological, incl. embryonic, induced Rett’s; hematological— pluripotent anemia 61 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3a. Cont’d universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Emery, Gregory U. Montréal QC Stem cells— Cancer No www.iric.ca/Recherche/Unites_Recherche/ [email protected] unspecifi ed Signalisation_vesiculaire.htm Emili, Andrew The Donnelly Centre—Banting and U. Toronto ON Stem cells—embryonic Cancer No lambda.med.utoronto.ca/Emili.htm [email protected] Best Department of Medical Research Farhat, Walid Hospital for Sick Children U. Toronto ON Tissue engineering — Urological No www.sickkids.ca/AboutSickKids/Directory/People/F/ [email protected] cells, scaffold Walid-Farhat-landing-page.html Farookhi, Riaz McGill U. QC Stem cells—ovarian Reproduction—ovary No www.medicine.mcgill.ca/physio/staffpages/rfarookhi. [email protected] epithelial htm Faucheux, Nathalie U. Sherbrooke QC Biomaterials— Musculoskeletal— CRC in Cell- www.usherbrooke.ca/gchimiquebiotech/personnel/ [email protected] scaffolds bone and cartilage Biomaterial professeurs/nathalie-faucheux/ regeneration Biohybrid Systems Favis, Basil École QC Biomaterials— Various No www.polymtl.ca/recherche/rc/en/professeurs/ [email protected] polytechnique de scaffolds details.php?NoProf=30&showtab=PUB Montréal Fehlings, Michael McEwen Centre for Regenerative U. Toronto ON Stem cells—neural Neurological—spinal No www.uhnresearch.ca/researchers/profi le. [email protected] Medicine and McLaughlin Centre for cord injury php?lookup=1781 Molecular Medicine, Toronto Western Research Institute, University Health Network Ferguson, Peter Charles Mount Sinai Hospital U. Toronto ON Stem cells— Musculoskeletal No orthopaedics.utoronto.ca/faculty/list/ferguson.htm [email protected] mesenchymal stromal Fernandes, Karl U. Montréal QC Stem cells—neural Neurological— CRC in Stem Cell www.cenum.umontreal.ca/membres/2_titulaires/ [email protected] neurodegenerative Neurobiology en_fernandes_k.html diseases, incl. Alzheimer’s Fernlund, Goran U. British BC Tissue engineering— Musculoskeletal No www.mtrl.ubc.ca/faculty_&_staff/fernlund.php [email protected] Columbia biomaterials, stem cells—mesenchymal Figeys, Daniel U. Ottawa ON Stem cells—cell Various No www.med.uottawa.ca/bmi/eng/fi geys.html dfi [email protected] handling Filiaggi, Mark J. Dalhousie U. NS Biomaterials Musculoskeletal— No faculty-server.dentistry.dal.ca/datasystems/faculty_ fi [email protected] bone website/Faculty_Staff_details.php?name=Mark_ Filiaggi§ion=presentations Flynn, Lauren Queen’s U. ON Stem cells—fat; Various No chemeng.queensu.ca/people/faculty/fl ynn/index.php lauren.fl [email protected] Tissue engineering— scaffolds Fradette, Julie LOEX U. Laval QC Stem cells—fat; Tissue Musculoskeletal No www.loex.gc.ca [email protected] engineering Frei, Hanspeter Carleton U. ON Stem cells— Musculoskeletal— No research.mae.carleton.ca/Faculty.html [email protected] mesenchymal bone Garnier, Alain U. Laval QC Bioprocessing—stem Various No www.gch.ulaval.ca/agarnier/ [email protected] cells—culture Gassas, Adam Hospital for Sick Children U. Toronto ON Stem cells— Cancer—leukemia No www.sickkids.ca/Research/LRG/LRG-members/dr- [email protected] hematopoietic adam-gassas/index.html Germain, Lucie LOEX U. Laval QC Stem cells—adult— Various, incl. CRC in Stem www.cha.quebec.qc.ca/en/www/research/the- [email protected] epithelial cutaneous, Cell and Tissue research-centre/researchers/lucie-germain/index. cardiovascular, eye Engineering html

62 appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER 3

universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Emery, Gregory U. Montréal QC Stem cells— Cancer No www.iric.ca/Recherche/Unites_Recherche/ [email protected] unspecifi ed Signalisation_vesiculaire.htm Emili, Andrew The Donnelly Centre—Banting and U. Toronto ON Stem cells—embryonic Cancer No lambda.med.utoronto.ca/Emili.htm [email protected] Best Department of Medical Research Farhat, Walid Hospital for Sick Children U. Toronto ON Tissue engineering — Urological No www.sickkids.ca/AboutSickKids/Directory/People/F/ [email protected] cells, scaffold Walid-Farhat-landing-page.html Farookhi, Riaz McGill U. QC Stem cells—ovarian Reproduction—ovary No www.medicine.mcgill.ca/physio/staffpages/rfarookhi. [email protected] epithelial htm Faucheux, Nathalie U. Sherbrooke QC Biomaterials— Musculoskeletal— CRC in Cell- www.usherbrooke.ca/gchimiquebiotech/personnel/ [email protected] scaffolds bone and cartilage Biomaterial professeurs/nathalie-faucheux/ regeneration Biohybrid Systems Favis, Basil École QC Biomaterials— Various No www.polymtl.ca/recherche/rc/en/professeurs/ [email protected] polytechnique de scaffolds details.php?NoProf=30&showtab=PUB Montréal Fehlings, Michael McEwen Centre for Regenerative U. Toronto ON Stem cells—neural Neurological—spinal No www.uhnresearch.ca/researchers/profi le. [email protected] Medicine and McLaughlin Centre for cord injury php?lookup=1781 Molecular Medicine, Toronto Western Research Institute, University Health Network Ferguson, Peter Charles Mount Sinai Hospital U. Toronto ON Stem cells— Musculoskeletal No orthopaedics.utoronto.ca/faculty/list/ferguson.htm [email protected] mesenchymal stromal Fernandes, Karl U. Montréal QC Stem cells—neural Neurological— CRC in Stem Cell www.cenum.umontreal.ca/membres/2_titulaires/ [email protected] neurodegenerative Neurobiology en_fernandes_k.html diseases, incl. Alzheimer’s Fernlund, Goran U. British BC Tissue engineering— Musculoskeletal No www.mtrl.ubc.ca/faculty_&_staff/fernlund.php [email protected] Columbia biomaterials, stem cells—mesenchymal Figeys, Daniel U. Ottawa ON Stem cells—cell Various No www.med.uottawa.ca/bmi/eng/fi geys.html dfi [email protected] handling Filiaggi, Mark J. Dalhousie U. NS Biomaterials Musculoskeletal— No faculty-server.dentistry.dal.ca/datasystems/faculty_ fi [email protected] bone website/Faculty_Staff_details.php?name=Mark_ Filiaggi§ion=presentations Flynn, Lauren Queen’s U. ON Stem cells—fat; Various No chemeng.queensu.ca/people/faculty/fl ynn/index.php lauren.fl [email protected] Tissue engineering— scaffolds Fradette, Julie LOEX U. Laval QC Stem cells—fat; Tissue Musculoskeletal No www.loex.gc.ca [email protected] engineering Frei, Hanspeter Carleton U. ON Stem cells— Musculoskeletal— No research.mae.carleton.ca/Faculty.html [email protected] mesenchymal bone Garnier, Alain U. Laval QC Bioprocessing—stem Various No www.gch.ulaval.ca/agarnier/ [email protected] cells—culture Gassas, Adam Hospital for Sick Children U. Toronto ON Stem cells— Cancer—leukemia No www.sickkids.ca/Research/LRG/LRG-members/dr- [email protected] hematopoietic adam-gassas/index.html Germain, Lucie LOEX U. Laval QC Stem cells—adult— Various, incl. CRC in Stem www.cha.quebec.qc.ca/en/www/research/the- [email protected] epithelial cutaneous, Cell and Tissue research-centre/researchers/lucie-germain/index. cardiovascular, eye Engineering html

63 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3a. Cont’d universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Geyer, Ronald U. Saskatchewan Sask Stem cells—cancer Cancer No www.saskcancer.ca/Default.aspx?DN=a7fb7a71- N/A 3960-4787-b700-e2925d8a7c8a Ghanekar, Anand U. Toronto ON Stem cells—cancer Cancer—liver No www.uhnres.utoronto.ca/researchers/profi le. [email protected] php?lookup=2011 Ghanem, Amyl Dalhousie U. NS Biomaterials—tissue Various No chemicalengineering.dal.ca/Faculty/Research/ [email protected] engineering Dr._A._Ghanem_.php Giacomantonio, Carman A. Dalhousie U. NS Stem cells—cancer Cancer No generalsurgery.medicine.dal.ca/faculty. N/A htm#Giacomantonio Giasson, Claude J. LOEX affi liation U. Montréal QC Tissue engineering Eye No mapageweb.umontreal.ca/giassonc/ [email protected]

Glass, Kathleen McGill U. QC Social science & SSH: Ethics, legal No www.mcgill.ca/biomedicalethicsunit/faculty/glass/ [email protected] humanities Golding, Michael C. U. Western ON Stem cells—various— Embryogenesis No vetmed.tamu.edu/vtpp/directorydetail?userid=9942; N/A Ontario (moved unspecifi ed vetmed.tamu.edu/rsl/faculty/michael-golding to Texas A&M U. June 2010) Goulet, Francine LOEX U. Laval QC Tissue engineering— Musculoskeletal No www.cha.quebec.qc.ca/en/www/research/the- [email protected] biomaterials, culture research-centre/researchers/francine-goulet/index. html Gramolini, Anthony Orlando The Donnelly Centre, Banting and U. Toronto ON Stem cells— Cardiovascular CRC in www.physiology.utoronto.ca/res/list/gramolini.htm [email protected] Best Department of Medical Research unspecifi ed Cardiovascular Proteomics and Molecular Therapeutics Grant, Denis U. Toronto ON Stem cells— Cancer No www.pharmtox.utoronto.ca/faculty/directory/grant. [email protected] pluripotent— htm embryonic, induced pluripotent Greenblatt, Jack The Donnelly Centre, Banting and U. Toronto ON Stem cells— Various No tdccbr.med.utoronto.ca/members/jack_greenblatt. [email protected] Best Department of Medical Research unspecifi ed html Gregory-Evan, Kevin Vancouver Coastal Health Research U. British BC Stem cells—embryonic Eye Julia Levy B.C. www.ophthalmology.ubc.ca/faculty_pages/k- [email protected] Institute Columbia Leadership gregory-evans.html Chair in Macular Research Grenier, Guillaume U. Sherbrooke QC Stem cells—muscle Musculoskeletal— No www.usherbrooke.ca/departement-chirurgie/ [email protected] progenitors muscle francais/recherche/professeurs-ayant-une-activite- de-recherche/fi ches-de-professeurs/guillaume Griffi th, May Sprott Centre for Stem Cell Research, U. Ottawa ON Biomaterials— Eye No www.ohri.ca/profi les/griffi th.asp mgriffi [email protected] Ottawa Health Research Institute scaffolds; Tissue engineering—stem cells Guidos, Cynthia Hospital for Sick Children U. Toronto ON Stem cells— Cancer—leukemia No www.sickkids.ca/Research/Guidos-Lab/index.html [email protected] hematopoietic Gutkowska, Jolanta Centre de recherche du Centre U. Montréal QC Stem cells—embryonic Cardiology No chumtl.qc.ca/crchum/chercheurs/chercheurs-liste/ [email protected] hospitalier de l’Université de Montréal gutkowska-j.en.html?mode=print Hamilton, Douglas U. Western ON Biomaterials; Tissue Dental No www.uwo.ca/anatomy/department/hamiltond/ [email protected] Ontario engineering dhamilton.html Hansen, David U. Calgary AB Stem cells— Various No homepages.ucalgary.ca/~dhansen/ [email protected] unspecifi ed

64 appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER 3

universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Geyer, Ronald U. Saskatchewan Sask Stem cells—cancer Cancer No www.saskcancer.ca/Default.aspx?DN=a7fb7a71- N/A 3960-4787-b700-e2925d8a7c8a Ghanekar, Anand U. Toronto ON Stem cells—cancer Cancer—liver No www.uhnres.utoronto.ca/researchers/profi le. [email protected] php?lookup=2011 Ghanem, Amyl Dalhousie U. NS Biomaterials—tissue Various No chemicalengineering.dal.ca/Faculty/Research/ [email protected] engineering Dr._A._Ghanem_.php Giacomantonio, Carman A. Dalhousie U. NS Stem cells—cancer Cancer No generalsurgery.medicine.dal.ca/faculty. N/A htm#Giacomantonio Giasson, Claude J. LOEX affi liation U. Montréal QC Tissue engineering Eye No mapageweb.umontreal.ca/giassonc/ [email protected]

65 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3a. Cont’d universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Harvey, Edward McGill U. QC Biomaterials; Tissue Musculoskeletal— No www.medicine.mcgill.ca/orthopaedics/faculty.htm [email protected] engineering—cells bone Hassell, John McMaster U. ON Stem cells—adult, Cancer No www.biology.mcmaster.ca/faculty/hassell/hassell. [email protected] cancer htm Hawke, Thomas McMaster U. ON Stem cells—muscle Musculoskeletal— No fhs.mcmaster.ca/pathology/contact_us/faculty/ [email protected] progenitor muscle faculty_bios/Hawke_000.html Hazell, Alan Stewart Centre de recherché du Centre U. Montréal QC Stem cells—neural Neurological—brain No www.chumtl.qc.ca/crchum/chercheurs/chercheurs- [email protected] hospitalier de l’Université de Montréal injury liste/hazell-as.en.html Hebert, Marie-Josee Centre de recherche du Centre U. Montréal QC Stem cells— Various—renal, No www.chumtl.qc.ca/crchum/chercheurs/chercheurs- [email protected] hospitalier de l’Université de Montréal mesenchymal cardiovascular liste/hebert-mj.fr.html Hedley, David William Ontario Cancer Institute, University U. Toronto ON Stem cells—cancer Cancer—cervical No www.uhnres.utoronto.ca/researchers/profi le. [email protected] Health Network php?lookup=2395 Helgason, Cheryl BC Cancer Agency U. British BC Stem cells—embryonic Immunological— No www.bccrc.ca/dept/et/personnel - content/senior- [email protected] Columbia autoimmune scientists/cheryl-helgason Hess, David John P. Robarts Research Institute U. Western ON Stem cells—bone Various— No www.robarts.ca/david-hess [email protected] Ontario marrow (mesenchymal, cardiovascular; hematopoietic) Metabolic—diabetes Heveker, Nikolaus Hôpital Sainte-Justine U. Montréal QC Stem cells— Various No www.chu-sainte-justine.org/research/chercheurs. nikolaus.heveker@recherche-ste-justine. hematopoietic aspx?ID_NOUVEAU=35430911&id_page=2432&id_ qc.ca menu=2429 Hicks, Geoffrey Cancer Care Manitoba—Institute of U. Manitoba MB Stem cells—embryonic Cancer CRC in Functional www.umanitoba.ca/institutes/manitoba_institute_ [email protected] Cell Biology Genomics cell_biology/MICB/hicks_geoff.htm Hill, David Lawson Health Research Institute, U. Western ON Stem cells—adult Metabolic—diabetes No www.uwo.ca/physpharm/faculty/hill_david.html [email protected] London Health Sciences Centre Ontario Hill, Richard Ontario Cancer Institute, University U. Toronto ON Stem cells—cancer Cancer—cervical No www.uhnres.utoronto.ca/researchers/profi le. [email protected] Health Network php?lookup=2445 Hoang, Trang Institute for Research in Immunology U. Montréal QC Stem cells— Cancer—leukemia CRC in Cell www.iric.ca/Recherche/Chercheurs/Hoang_T.html [email protected] and Cancer hematopoietic Differentiation and the Genetics of Acute Leukemias Hoare, Todd McMaster U. ON Biomaterials Various No chemeng.mcmaster.ca/hoare.html [email protected]

Hoemann, Caroline École QC Tissue engineering— Musculoskeletal No www.polymtl.ca/recherche/rc/en/professeurs/ [email protected] polytechnique de cells; Biomaterials details.php?NoProf=347 Montréal Hogge, Donna Terry Fox Laboratory, BC Cancer U. British BC Stem cells— Cancer—leukemia No www.bccrc.ca/dept/terry-fox-laboratory/faculty/ [email protected] Agency Columbia hematopoietic Hogge Hombach-Klonisch, Sabine U. Manitoba MB Stem cells—cancer Cancer No www.umanitoba.ca/faculties/medicine/units/ [email protected] anatomy/hombachks.html Hoodless, Pamela Terry Fox Laboratory, BC Cancer U. British BC Stem cells—embryonic Embryogenesis No www.bccrc.ca/dept/terry-fox-laboratory/faculty/dr.- [email protected] Agency Columbia pamela-hoodless-phd Hope, Kristin Jill Stem Cell and Cancer Research McMaster U. ON Stem cells— Cancer—leukemia No sccri.mcmaster.ca/hope_kristin.html [email protected] Institute hematopoietic Horb, Markoe Institut de recherches cliniques de U. Montréal QC Stem cells— Metabolic—diabetes No www.montreal-diabetes-research-center.org/en/ [email protected] Montréal adult—endodermal horb/horb.asp progenitors

66 appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER 3

universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Harvey, Edward McGill U. QC Biomaterials; Tissue Musculoskeletal— No www.medicine.mcgill.ca/orthopaedics/faculty.htm [email protected] engineering—cells bone Hassell, John McMaster U. ON Stem cells—adult, Cancer No www.biology.mcmaster.ca/faculty/hassell/hassell. [email protected] cancer htm Hawke, Thomas McMaster U. ON Stem cells—muscle Musculoskeletal— No fhs.mcmaster.ca/pathology/contact_us/faculty/ [email protected] progenitor muscle faculty_bios/Hawke_000.html Hazell, Alan Stewart Centre de recherché du Centre U. Montréal QC Stem cells—neural Neurological—brain No www.chumtl.qc.ca/crchum/chercheurs/chercheurs- [email protected] hospitalier de l’Université de Montréal injury liste/hazell-as.en.html Hebert, Marie-Josee Centre de recherche du Centre U. Montréal QC Stem cells— Various—renal, No www.chumtl.qc.ca/crchum/chercheurs/chercheurs- [email protected] hospitalier de l’Université de Montréal mesenchymal cardiovascular liste/hebert-mj.fr.html Hedley, David William Ontario Cancer Institute, University U. Toronto ON Stem cells—cancer Cancer—cervical No www.uhnres.utoronto.ca/researchers/profi le. [email protected] Health Network php?lookup=2395 Helgason, Cheryl BC Cancer Agency U. British BC Stem cells—embryonic Immunological— No www.bccrc.ca/dept/et/personnel - content/senior- [email protected] Columbia autoimmune scientists/cheryl-helgason Hess, David John P. Robarts Research Institute U. Western ON Stem cells—bone Various— No www.robarts.ca/david-hess [email protected] Ontario marrow (mesenchymal, cardiovascular; hematopoietic) Metabolic—diabetes Heveker, Nikolaus Hôpital Sainte-Justine U. Montréal QC Stem cells— Various No www.chu-sainte-justine.org/research/chercheurs. nikolaus.heveker@recherche-ste-justine. hematopoietic aspx?ID_NOUVEAU=35430911&id_page=2432&id_ qc.ca menu=2429 Hicks, Geoffrey Cancer Care Manitoba—Institute of U. Manitoba MB Stem cells—embryonic Cancer CRC in Functional www.umanitoba.ca/institutes/manitoba_institute_ [email protected] Cell Biology Genomics cell_biology/MICB/hicks_geoff.htm Hill, David Lawson Health Research Institute, U. Western ON Stem cells—adult Metabolic—diabetes No www.uwo.ca/physpharm/faculty/hill_david.html [email protected] London Health Sciences Centre Ontario Hill, Richard Ontario Cancer Institute, University U. Toronto ON Stem cells—cancer Cancer—cervical No www.uhnres.utoronto.ca/researchers/profi le. [email protected] Health Network php?lookup=2445 Hoang, Trang Institute for Research in Immunology U. Montréal QC Stem cells— Cancer—leukemia CRC in Cell www.iric.ca/Recherche/Chercheurs/Hoang_T.html [email protected] and Cancer hematopoietic Differentiation and the Genetics of Acute Leukemias Hoare, Todd McMaster U. ON Biomaterials Various No chemeng.mcmaster.ca/hoare.html [email protected]

67 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3a. Cont’d universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Hough, Margaret Sunnybrook Research Institute U. Toronto ON Stem cells— Genetic No sunnybrook.ca/research/team/member. margaret.hough@ sri.utoronto.ca various—embryonic, asp?t=11&m=83&page=172 hematopoietic Huang, Annie Hospital for Sick Children U. Toronto ON Stem cells—neural Cancer—brain No www.sickkids.ca/AboutSickKids/Directory/People/H/ [email protected] Annie-A-Huang.html Huang, Sui U. Calgary AB Stem cells—embryonic Hematological No www.bio.ucalgary.ca/contact/faculty/huang.html [email protected]

Hughes, Timothy The Donnelly Centre—Banting and U. Toronto ON Stem cells—embryonic Various No hugheslab.med.utoronto.ca/ [email protected] Best Department of Medical Research Hui, Chi-chung Hospital for Sick Children U. Toronto ON Stem cells—various— Neurological No www.sickkids.ca/AboutSickKids/Directory/People/H/ [email protected] unspecifi ed Chi-chung-Hu.html Humphries, Keith Terry Fox Laboratory, BC Cancer U. British BC Stem cells— Hematological— No www.terryfoxlab.ca/people/khumphries/keith.aspx [email protected] Agency Columbia hematopoietic anemia, cancer Hunter, Christopher U. Calgary AB Tissue engineering— Musculoskeletal—disc No www.eng.ucalgary.ca/resrch_mech/Mech_Hunter. [email protected] stem cells; htm Biomaterials Husain, Mansoor McEwen Centre for Regenerative U. Toronto ON Stem cells—embryonic Cardiovascular No uhnres.utoronto.ca/researchers/profi le. [email protected] Medicine, Toronto General Research php?lookup=2610 Institute, University Health Network Illes, Judy U. British BC Social science & SSH: Ethics CRCin www.neuroethics.ubc.ca/National_Core_for_ [email protected] Columbia humanities Neuroethics Neuroethics/People.html Ingram, Liz U. Alberta AB Social science & SSH: Social No www.artdesign.ualberta.ca/Faculty_and_Staff/ [email protected] humanities Faculty/Liz_Ingram.aspx Iscove, Norman McEwen Centre for Regenerative U. Toronto ON Stem cells— Cancer—leukemia No www.uhnresearch.ca/researchers/profi le. [email protected] Medicine, and Ontario Cancer hematopoietic php?lookup=2679 Institute, University Health Network Jackson, Michael U. Manitoba MB Stem cells—bone Cardiology No www.umanitoba.ca/faculties/medicine/units/ N/A marrow pharmacology/faculty_members/index.html Jervis, Eric U. Waterloo ON Bioprocessing—cell Various No chemeng.uwaterloo.ca/faculty/jervis.html [email protected] culture; Tissue engineering Jiang, Xiaoyan Terry Fox Laboratory, BC Cancer U. British BC Stem cells— Cancer—leukemia No www.terryfoxlab.ca/people/XJiang/xiaoyan.aspx [email protected] Agency Columbia hematopoietic Jirik, Frank Southern Alberta Cancer Research U. Calgary AB Stem cells—adult Cancer No www.sacri.ucalgary.ca/node/158 [email protected] Institute Johnson, James U. British BC Stem cells— Metabolic—diabetes No www.cellphys.ubc.ca/faculty_pages/johnson.html [email protected] Columbia pancreatic (islet) Johnston, James U. Saskatchewan Sask Tissue engineering— Musculoskeletal No www.engr.usask.ca/faculty/Johnston_James.php [email protected] scaffolds Jolicoeur, Mario École QC Bioprocessing Various CRC in Applied www.polymtl.ca/bio-p2/ [email protected] polytechnique de Metabolic Montréal Engineering Jolicoeur, Paul Institut de recherches cliniques de U. Montréal QC Stem cells—various— Cancer CRC in in Studies en.wikipedia.org/wiki/Paul_Jolicoeur www.ircm. [email protected] Montréal cancer/mammary of Pathogenesis qc.ca/fr/recherche/statique/unite4.html of Retrovirus— Induced Diseases Jones, Elizabeth McGill U. QC Tissue engineering Cardiovascular CRC in Embryonic people.mcgill.ca/elizabeth.jones3/ [email protected] Biomechanics 68 appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER 3

universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Hough, Margaret Sunnybrook Research Institute U. Toronto ON Stem cells— Genetic No sunnybrook.ca/research/team/member. margaret.hough@ sri.utoronto.ca various—embryonic, asp?t=11&m=83&page=172 hematopoietic Huang, Annie Hospital for Sick Children U. Toronto ON Stem cells—neural Cancer—brain No www.sickkids.ca/AboutSickKids/Directory/People/H/ [email protected] Annie-A-Huang.html Huang, Sui U. Calgary AB Stem cells—embryonic Hematological No www.bio.ucalgary.ca/contact/faculty/huang.html [email protected]

3a. Cont’d universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Jones, Kim McMaster U. ON Biomaterials Various, incl. No chemeng.mcmaster.ca/jones.html [email protected] immunological Joshi, Sadhna U. Toronto ON Stem cells— Infection—HIV No www.utoronto.ca/idmicro/ [email protected] hematopoietic Julius, Michael Sunnybrook Research Institute U. Toronto ON Stem cells—embryonic Various, incl. No www.immunology.utoronto.ca/faculty/directory/ [email protected] immunological, cancer, julius.htm infection Kaern, Mads U. Ottawa ON Stem cells—embryonic Various CRC in Systems www.med.uottawa.ca/Associations/OISB/members/ [email protected] Biology member_mads_kaern.htm Kallos, Michael Includes: Pharmaceutical Production U. Calgary AB Bioprocessing—stem Various No schulich.ucalgary.ca/resrch_chem/Chem_Kallos.htm [email protected] Research Facility cells, tissue culture Kamacheva, Eugenia U. Toronto ON Biomaterials Various No www.chem.utoronto.ca/staff/EK/index.htm [email protected]

Kamnasaran, Deepak U. Laval QC Stem cells—cancer Cancer—brain No kamnasaran.yolasite.com/ [email protected]

Kandel, Rita Samuel Lunenfeld Research Institute, U. Toronto ON Tissue engineering— Musculoskeletal No www.lunenfeld.ca/researchers/kandel [email protected] Mount Sinai Hospital biomaterials, stem cells Kaplan, David Hospital for Sick Children U. Toronto ON Stem cells—cancer Cancer CRC in in www.sickkids.ca/AboutSickKids/Directory/People/K/ [email protected] Cancer and David-Kaplan.html Neuroscience Karimi-Abdolrezaee, Soheila U. Manitoba MB Stem cells—neural Neurological—spinal No www.mich.ca/index.php?page=9&id=64 [email protected] cord injury Karsan, Aly BC Cancer Agency U. British BC Stem cells— Cancer—leukemia No www.bccrc.ca/dept/cmsgsc/faculty/dr-aly-karsan- [email protected] Columbia hematopoietic md/?searchterm=Karsan Keating, Armand U. Toronto ON Stem cells— Cancer— Epstein Chair in www.armandkeating.com [email protected] bone marrow— hematological Cell Therapy and mesenchymal, Transplantation hematopoietic Keeley, Fred Hospital for Sick Children U. Toronto ON Biomaterials Cardiovascular Heart and Stroke www.sickkids.ca/AboutSickKids/Directory/People/K/ [email protected] Foundation of Frederick-Keeley-staff-profi le.html Ontario—Robert M. Freedom Chair in Cardiovascular Science Keller, Gordon McEwen Centre for Regenerative U. Toronto ON Stem cells—embryonic Various, incl. CRC in Embryonic www.uhn.ca/donate/tgwh/site/mcewen/bio_keller. [email protected] Medicine and Ontario Cancer hematological, Stem Cell Biology asp Institute, University Health Network cardiovascular Kelly, Kevin Francis Stem Cell and Cancer Research McMaster U. ON Stem cells—embryonic Various, incl. No sccri.mcmaster.ca/kelly_kevin.html [email protected] Institute cutaneous, cancer Khan, Zia U. Western ON Stem cells—vascular Various No www.uwo.ca/pathol/faculty/khan.html [email protected] Ontario Kieffer, Tim U. British BC Stem cells— Metabolic—diabetes No www.cellphys.ubc.ca/faculty_pages/kieffer.html [email protected] Columbia gastrointestinal Kim, Seung Vancouver Coastal Health Research U. British BC Stem cells—neural Neurological No www.brain.ubc.ca/people.htm#K [email protected] Institute Columbia Kislinger, Thomas Ontario Cancer Institute, UHN U. Toronto ON Stem cells— Cardiovascular No www.uhnres.utoronto.ca/researchers/profi le. [email protected] unspecifi ed php?lookup=12469

70 appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER 3

universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Jones, Kim McMaster U. ON Biomaterials Various, incl. No chemeng.mcmaster.ca/jones.html [email protected] immunological Joshi, Sadhna U. Toronto ON Stem cells— Infection—HIV No www.utoronto.ca/idmicro/ [email protected] hematopoietic Julius, Michael Sunnybrook Research Institute U. Toronto ON Stem cells—embryonic Various, incl. No www.immunology.utoronto.ca/faculty/directory/ [email protected] immunological, cancer, julius.htm infection Kaern, Mads U. Ottawa ON Stem cells—embryonic Various CRC in Systems www.med.uottawa.ca/Associations/OISB/members/ [email protected] Biology member_mads_kaern.htm Kallos, Michael Includes: Pharmaceutical Production U. Calgary AB Bioprocessing—stem Various No schulich.ucalgary.ca/resrch_chem/Chem_Kallos.htm [email protected] Research Facility cells, tissue culture Kamacheva, Eugenia U. Toronto ON Biomaterials Various No www.chem.utoronto.ca/staff/EK/index.htm [email protected]

Kamnasaran, Deepak U. Laval QC Stem cells—cancer Cancer—brain No kamnasaran.yolasite.com/ [email protected]

71 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3a. Cont’d universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Klonisch, Thomas CancerCare Manitoba U. Manitoba MB Stem cells—cancer Cancer No www.umanitoba.ca/faculties/medicine/units/ [email protected] anatomy/klonischt.html Knoppers, Bartha McGill U. QC Social science & SSH: Ethics, law, policy No academic.mcgill.ca/newfac/profi les/2009/by-name/ [email protected] humanities knoppers.htm Ko, Frank U. British BC Tissue engineering— Various CRC in in afml.ampel.ubc.ca/ProfKo.php [email protected] Columbia scaffolds Advanced Fibrous Materials Korbutt, Gregory Alberta Diabetes Institute U. Alberta AB Tissue engineering— Metabolic—diabetes; No www.adi.med.ualberta.ca/Home/Research/ [email protected] stem cells, islet; Other PrincipalInvestigators/Bio/korbutt.cfm Transplantation Kothary, Rashmi K. Ottawa Hospital Research Institute U. Ottawa ON Stem cells—embryonic Various, incl. University Health www.ohri.ca/profi les/kothary.asp [email protected] neurological, Research Chair in cardiovascular Neuromuscular Disorders Kreplak, Laurent Dalhousie U. NS Biomaterials— Various No fi zz.phys.dal.ca/~kreplak/?page_id=14 [email protected] scaffolds Krieger, Charles Simon Fraser U. BC Stem cells—bone Neurological No www2.fas.sfu.ca/kin/Faculty/Krieger.html [email protected] marrow Krylov, Sergey N. York U. ON Stem cells— Various CRC in www.chem.yorku.ca/profs/krylov/ [email protected] unspecifi ed Bioanalytical Chemistry Krystal, Gerald Terry Fox Laboratory, BC Cancer U. British BC Stem cells— Cancer No www.bccrc.ca/dept/terry-fox-laboratory/faculty/ [email protected] Agency Columbia hematopoietic Krystal Kuruvilla, John Ontario Cancer Institute, University U. Toronto ON Stem cells— Cancer— No N/A [email protected] Health Network unspecifi ed hematological Kwon, Brian U. British BC Stem cells— Neurological—spinal No www.orthosurgery.ubc.ca/faculty_bios/kwon.html [email protected] Columbia unspecifi ed cord injury Labbé, Jean-Claude U. Montréal QC Stem cells— Cancer CRC in Cellular www.iric.ca/Recherche/Chercheurs/Labbe_JC.html [email protected] unspecifi ed Division and Differentiation Lacroix, Dan LOEX U. Laval QC Tissue engineering Various No www.cha.quebec.qc.ca/en/www/research/the- [email protected] research-centre/researchers/dan-lacroix/index.html Lagace, Diane U. Ottawa ON Stem cells— Neurological No www.med.uottawa.ca/NSC/eng/lagace.htm [email protected] unspecifi ed Lajoie, Gilles U. Western ON Stem cells—embryonic Various; Proteomics No www.biochem.uwo.ca/fac/lajoie/ [email protected] Ontario Langelier, Eve U. Sherbrooke QC Tissue engineering; Musculoskeletal No www.usherbrooke.ca/gmecanique/departement/ [email protected] Biomaterials personnel/professeurs/eve-langelier/ Lansdorp, Peter Terry Fox Laboratory, BC Cancer U. British BC Stem cells—various— Cancer, other No www.bccrc.ca/dept/terry-fox-laboratory/faculty/ [email protected] Agency Columbia hematopoietic, induced Lansdorp pluripotent, embryonic Laposa, Rebecca U. Toronto ON Stem cells—neural Neurological No www.pharmtox.utoronto.ca/faculty/directory/laposa. [email protected] htm Larouche, Danielle LOEX U. Laval QC Stem cells— Various No www.cha.quebec.qc.ca/en/www/research/the- [email protected] unspecifi ed research-centre/researchers/danielle-larouche/ index.html Leavitt, Blair Centre for Molecular Medicine & U. British BC Stem cells— Neurological No www.cmmt.ubc.ca/research/investigators/leavitt/lab [email protected] Therapeutics Columbia unspecifi ed

72 appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER 3

universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Klonisch, Thomas CancerCare Manitoba U. Manitoba MB Stem cells—cancer Cancer No www.umanitoba.ca/faculties/medicine/units/ [email protected] anatomy/klonischt.html Knoppers, Bartha McGill U. QC Social science & SSH: Ethics, law, policy No academic.mcgill.ca/newfac/profi les/2009/by-name/ [email protected] humanities knoppers.htm Ko, Frank U. British BC Tissue engineering— Various CRC in in afml.ampel.ubc.ca/ProfKo.php [email protected] Columbia scaffolds Advanced Fibrous Materials Korbutt, Gregory Alberta Diabetes Institute U. Alberta AB Tissue engineering— Metabolic—diabetes; No www.adi.med.ualberta.ca/Home/Research/ [email protected] stem cells, islet; Other PrincipalInvestigators/Bio/korbutt.cfm Transplantation Kothary, Rashmi K. Ottawa Hospital Research Institute U. Ottawa ON Stem cells—embryonic Various, incl. University Health www.ohri.ca/profi les/kothary.asp [email protected] neurological, Research Chair in cardiovascular Neuromuscular Disorders Kreplak, Laurent Dalhousie U. NS Biomaterials— Various No fi zz.phys.dal.ca/~kreplak/?page_id=14 [email protected] scaffolds Krieger, Charles Simon Fraser U. BC Stem cells—bone Neurological No www2.fas.sfu.ca/kin/Faculty/Krieger.html [email protected] marrow Krylov, Sergey N. York U. ON Stem cells— Various CRC in www.chem.yorku.ca/profs/krylov/ [email protected] unspecifi ed Bioanalytical Chemistry Krystal, Gerald Terry Fox Laboratory, BC Cancer U. British BC Stem cells— Cancer No www.bccrc.ca/dept/terry-fox-laboratory/faculty/ [email protected] Agency Columbia hematopoietic Krystal Kuruvilla, John Ontario Cancer Institute, University U. Toronto ON Stem cells— Cancer— No N/A [email protected] Health Network unspecifi ed hematological Kwon, Brian U. British BC Stem cells— Neurological—spinal No www.orthosurgery.ubc.ca/faculty_bios/kwon.html [email protected] Columbia unspecifi ed cord injury Labbé, Jean-Claude U. Montréal QC Stem cells— Cancer CRC in Cellular www.iric.ca/Recherche/Chercheurs/Labbe_JC.html [email protected] unspecifi ed Division and Differentiation Lacroix, Dan LOEX U. Laval QC Tissue engineering Various No www.cha.quebec.qc.ca/en/www/research/the- [email protected] research-centre/researchers/dan-lacroix/index.html Lagace, Diane U. Ottawa ON Stem cells— Neurological No www.med.uottawa.ca/NSC/eng/lagace.htm [email protected] unspecifi ed Lajoie, Gilles U. Western ON Stem cells—embryonic Various; Proteomics No www.biochem.uwo.ca/fac/lajoie/ [email protected] Ontario Langelier, Eve U. Sherbrooke QC Tissue engineering; Musculoskeletal No www.usherbrooke.ca/gmecanique/departement/ [email protected] Biomaterials personnel/professeurs/eve-langelier/ Lansdorp, Peter Terry Fox Laboratory, BC Cancer U. British BC Stem cells—various— Cancer, other No www.bccrc.ca/dept/terry-fox-laboratory/faculty/ [email protected] Agency Columbia hematopoietic, induced Lansdorp pluripotent, embryonic Laposa, Rebecca U. Toronto ON Stem cells—neural Neurological No www.pharmtox.utoronto.ca/faculty/directory/laposa. [email protected] htm Larouche, Danielle LOEX U. Laval QC Stem cells— Various No www.cha.quebec.qc.ca/en/www/research/the- [email protected] unspecifi ed research-centre/researchers/danielle-larouche/ index.html Leavitt, Blair Centre for Molecular Medicine & U. British BC Stem cells— Neurological No www.cmmt.ubc.ca/research/investigators/leavitt/lab [email protected] Therapeutics Columbia unspecifi ed

73 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3a. Cont’d universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Lecanu, Laurent The Research Institute of the McGill McGill U. QC Stem cells—neural Neurological No muhc.ca/research/researcher/laurent-lecanu-msc- N/A University Health Centre phd Lee, Patrick WK Dalhousie U. NS Stem cells—cancer Cancer No microbiology.medicine.dal.ca/people/plee/ [email protected]

Lefebvre, Louis U. British BC Stem cells—embryonic Genetic CRC in Genomic www.medgen.ubc.ca/research/research_faculty/ [email protected] Columbia Imprinting llefebvre.htm Legge, Raymond U. Waterloo ON Tissue engineering— Various No chemeng.uwaterloo.ca/faculty/legge.html [email protected] scaffolds Leibing, Annette U. Montréal QC Social science & SSH: Social No www.meos.qc.ca [email protected] humanities Lemmens, Trudo U. Toronto ON Social science & SSH: Law No www.law.utoronto.ca/faculty_content.asp?profi le=33 [email protected] humanities &cType=facMembers&itemPath=1/3/4/0/0 Leroux, Therese U. Montréal QC Social science & SSH: Policy No www.crdp.umontreal.ca/en/chercheurs/leroux_ [email protected] humanities therese/index.html Lessard, Julie Institute for Research in Immunology U. Montréal QC Stem cells— Cancer— CRC in Molecular www.iric.ca/Recherche/Chercheurs/Lessard_FR.htm [email protected] and Cancer hematopoietic hematological Genetics of Stem Cell Hematopoiesis Levesque, Eric Centre hospitalier de l’Université Laval U. Laval QC Stem cells— Cancer No www.pharmacogenomics.pha.ulaval.ca/sgc/lang/ [email protected] hematopoietic en_CA/pid/10271 Levin, Leonard Centre de recherche de l’Hôpital U. Montréal QC Stem cells—neural Eye CRC in recherche.maisonneuve-rosemont.org/en-ca/ [email protected] Maisonneuve-Rosemont Ophtalmology research/our-research-investigators/levin-leonard. and Vision html Sciences Levy, Gary Toronto General Research Institute, U. Toronto ON Stem cells—various— Various, incl. No www.uhnres.utoronto.ca/researchers/profi le. [email protected] University Health Network unspecifi ed immunological php?lookup=3442 Lewis, James Franklin Lawson Health Research Institute, U. Western ON Stem cells—bone Immunological— No dom.lhsc.on.ca/dom/divisions/respirology/jl.htm jfl [email protected] London Health Sciences Centre Ontario marrow infl ammation Li, Julang U. Guelph ON Stem cells—dermal Reproduction—female; No www.aps.uoguelph.ca/?action=faculty&id=104 [email protected] Other Li, Ren-Ke McEwen Centre for Regenerative U. Toronto ON Stem cells— Cardiovascular, CRC in Cardiac www.mcewencentre.com/bio_li.asp [email protected] Medicine, Toronto General Research hematopoietic cardiology Regeneration Institute, University Health Network Lilicrap, David Queen’s U. ON Stem cells— Hematological— No www.path.queensu.ca/labs/lillicrap/ [email protected] unspecifi ed hemophilia Ly, Hung Montreal Heart Institute U. Montréal QC Stem cells— Cardiology No www.icm-mhi.org/en/medecine-prof.html [email protected] mesenchymal Lynn, Francis U. British BC Stem cells—embryonic Metabolic—diabetes No www.surgery.ubc.ca/faculty/fclynn.html [email protected] Columbia Mak, Tak Ontario Cancer Institute, University U. Toronto ON Stem cells— Cancer No www.uhnresearch.ca/researchers/profi le. [email protected] Health Network mesenchymal php?lookup=3816 Marra, Marco BC Cancer Agency, Genome U. British BC Stem cells—embryonic Various No www.bcgsc.ca/faculty/mmarra/research/view [email protected] Sciences Centre Columbia Marshall, Aaron U. Manitoba MB Stem cells—various— Various CRC in Molecular umanitoba.ca/faculties/medicine/units/immunology/ [email protected] unspecifi ed Immunology marshallbio.html Massie, Bernard Associated with National Research U. Montréal QC Stem cells—various— Various, incl. No www.universadecouvrir.gc.ca/page/index. [email protected] Council—Biotechnology Research adult hematological— php?p=195&l=e Institute hemophilia

74 appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER 3

universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Lecanu, Laurent The Research Institute of the McGill McGill U. QC Stem cells—neural Neurological No muhc.ca/research/researcher/laurent-lecanu-msc- N/A University Health Centre phd Lee, Patrick WK Dalhousie U. NS Stem cells—cancer Cancer No microbiology.medicine.dal.ca/people/plee/ [email protected]

75 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3a. Cont’d universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Matyas, John Robert U. Calgary AB Stem cells—embryonic Musculoskeletal No www.cell.ucalgary.ca/j_matyas.html [email protected]

McBurney, Michael Ottawa Hospital Research Institute U. Ottawa ON Stem cells—embryonic Various—aging, No www.ohri.ca/profi les/mcburney.asp [email protected] cancer McDonald, Michael U. British BC Social science & SSH: Ethics No www.ethics.ubc.ca/index.php?p=personweb2 [email protected] Columbia humanities McElwee, Kevin Vancouver Coastal Health Research U. British BC Stem cells— Cutaneous No www.hairlaboratory.com/hair-laboratory-team/kevin- [email protected] Institute Columbia mesenchymal mcelwee.html McGann, Locksley Earl U. Alberta AB Technology— Various No www.experts.ualberta.ca/expert.cfm?id=40321 [email protected] Stem cells— cryopreservation McGuigan, Alison Institute of Biomaterials and U. Toronto ON Tissue engineering— Various No www.ibbme.utoronto.ca/Page502.aspx [email protected] Biomedical Engineering cells McInnes, Roderick Jewish General Hospital, Lady Davis McGill U. QC Stem cells—various— Various, incl. eye Alva Chair www.ladydavis.ca/en/rodmcinnes [email protected] Institute embryonic, adult in Human Genetics; CRC in Neurogenetics McKerlie, Colin Samuel Lunenfeld Research Institute, U. Toronto ON Stem cells—various— Various No www.sickkids.ca/AboutSickKids/Directory/People/M/ [email protected] Mount Sinai Hospital unspecifi ed Colin-McKerlie.html McNagny, Kelly Biomedical Research Centre U. British BC Stem cells— Various— No www.brc.ubc.ca/drupal5/node/39 [email protected] Columbia hematopoietic allergy, asthma, cardiovascular, hematological, neurological Meakin, Susan John P. Robarts Research Institute U. Western ON Stem cells— Neurological No www.robarts.ca/smeakin/ [email protected] Ontario unspecifi ed Megeney, Lynn Sprott Centre for Stem Cell Research, U. Ottawa ON Stem cells— Cardiovascular Mach Gaensslen www.ohri.ca/profi les/megeney.asp [email protected] Ottawa Health Research Institute myocardial Chair in Cardiac Research Mendez, Ivar Dalhousie U. NS Stem cells—fetal Neurological No neurosurgery.medicine.dal.ca/labs.htm [email protected]

Menon, Devidas U. Alberta AB Social science & SSH: Policy No www.publichealth.ualberta.ca/research/ [email protected] humanities researchers_supersivors/faculty/menon.aspx Mequanint, Kibret U. Western ON Tissue engineering— Various No www.eng.uwo.ca/research/compendium/faculty/ [email protected] Ontario scaffolds kmequanint.htm Merrifi eld, Peter U. Western ON Stem cells—muscle Musculoskeletal No www.uwo.ca/anatomy/department/merrifi eldp/ peter.merrifi [email protected] Ontario pmerrifi eld.html Metz, Luanne Associated with Hotchkiss Brain U. Calgary AB Stem cells—adult— Neurological—multiple No www.hbi.ucalgary.ca/members/metz [email protected] [email protected] Institute endogenous progenitor sclerosis Michalak, Marek S. U. Alberta AB Stem cells—embryonic Cardiovascular No www.biochem.ualberta.ca/faculty_detail.php?id=13 [email protected]

Midha, Rajiv Associated with Hotchkiss Brain U. Calgary AB Stem cells—dermal Neurological No www.hbi.ucalgary.ca/members/midha [email protected] Institute Miller, Freda McEwen Centre for Regenerative U. Toronto ON Stem cells—various— Neurological, incl. CRC in www.sickkids.ca/AboutSickKids/Directory/People/M/ [email protected] Medicine, Toronto General Research dermal, neural spinal cord injury Developmental Freda-Miller.html Institute, University Health Network Neurobiology Minden, Mark David Ontario Cancer Institute, University U. Toronto ON Stem cells— Cancer—leukemia No www.uhnresearch.ca/researchers/profi le. [email protected] Health Network hematopoietic php?lookup=4159

76 appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER 3

universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Matyas, John Robert U. Calgary AB Stem cells—embryonic Musculoskeletal No www.cell.ucalgary.ca/j_matyas.html [email protected]

77 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3a. Cont’d universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Moffat, Jason The Donnelly Centre U. Toronto ON Stem cells— Various No tdccbr.med.utoronto.ca/members/jason_moffat.html [email protected] pluripotent— induced pluripotent Mollica, Luigina Centre de recherche de l’Hôpital U. Montréal QC Stem cells— Various No recherche.maisonneuve-rosemont.org/en-ca/ [email protected] Maisonneuve-Rosemont hematopoietic research/our-research-investigators/mollica-luigina. html Moroy, Tarik Institut de recherches cliniques de U. Montréal QC Stem cells— Cancer— CRC in www.ircm.qc.ca/microsites/moroy/en/ [email protected] Montréal hematopoietic hematological Hematopoiesis and Immune Cell Differentiation Morris, Quaid The Donnelly Centre, Banting and U. Toronto ON Stem cells—embryonic Various No thedonnellycentre.utoronto.ca/members/quaid_ [email protected] Best Department of Medical Research morris.html Morshead, Cindi U. Toronto ON Stem cells—neural Neurological, other No www.utoronto.ca/morsheadlab/ [email protected]

Moulin, Véronique LOEX U. Laval QC Tissue engineering— Various No www.cha.quebec.qc.ca/en/www/research/the- [email protected] stem cells research-centre/researchers/veronique-moulin/ index.html Munoz Risueno, Ruth Stem Cell and Cancer Research McMaster U. ON Stem cells— Cancer—leukemia No sccri.mcmaster.ca/risueno_ruth_munoz.html [email protected] Institute hematopoietic Mwale, Fackson Jewish General Hospital, Lady Davis McGill U. QC Stem cells— Musculoskeletal—disc No www.ladydavis.ca/en/facksonmwale [email protected] Institute mesenchymal Nagano, Makoto The Research Institute of the McGill McGill U. QC Stem cells— Reproduction—male No people.muhc.ca/makoto.nagano/ [email protected] University Health Centre germline—sperm Nagy, Andras Samuel Lunenfeld Research Institute, U. Toronto ON Stem cells—various— Various, incl. cancer CRC in Stem Cells www.lunenfeld.ca/researchers/nagy [email protected] Mount Sinai Hospital and McEwen pluripotent— induced and Regeneration Centre for Regenerative Medicine, pluripotent, embryonic; University Health Network Somatic Nanci, Antonio U. Montréal QC Tissue engineering— Musculoskeletal No www.nancicalcifi edtissuegroup.com/ananci.htm [email protected] cells; Biomaterials Nazhat, Showan McGill U. QC Biomaterials— Musculoskeletal No www.mcgill.ca/dentistry/research/nazhat/ [email protected] scaffolds; Tissue engineering Neel, Benjamin Ontario Cancer Institute, University U. Toronto ON Stem cells—cancer Cancer—ovarian No www.uhnresearch.ca/researchers/profi le. [email protected] Health Network php?lookup=14776 Nemer, Mona U. Ottawa ON Stem cells— Cardiology No web5.uottawa.ca/admingov/biography_4.html N/A unspecifi ed Nevill, Thomas Vancouver Coastal Health Research U. British BC Stem cells— Cancer No www.leukemiabmtprogram.org/general_information/ [email protected] Institute Columbia hematopoietic about_us/our_doctors/nevill.html O’Brien, Catherine Adell Ontario Cancer Institute, University U. Toronto ON Stem cells—cancer Cancer—colorectal No generalsurgery.utoronto.ca/faculty/list/obrien.htm [email protected] Health Network Ohasi, Pamela Sumiko Ontario Cancer Institute, University U. Toronto ON Stem cells— Cancer CRC in www.uhnres.utoronto.ca/researchers/profi le. [email protected] Health Network mesenchymal Autoimmunity php?lookup=4520 and Tumour Immunity Opas, Michal J. U. Toronto ON Stem cells—embryonic Various— No icarus.med.utoronto.ca/patho/faculty. [email protected] musculoskeletal, asp?FacultyID=349 cardiovascular Paige, Christopher Ontario Cancer Institute, University U. Toronto ON Stem cells—various— Cancer No www.uhnres.utoronto.ca/researchers/profi le. [email protected] Health Network embryonic, cancer php?lookup=4608

78 appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER 3

universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Moffat, Jason The Donnelly Centre U. Toronto ON Stem cells— Various No tdccbr.med.utoronto.ca/members/jason_moffat.html [email protected] pluripotent— induced pluripotent Mollica, Luigina Centre de recherche de l’Hôpital U. Montréal QC Stem cells— Various No recherche.maisonneuve-rosemont.org/en-ca/ [email protected] Maisonneuve-Rosemont hematopoietic research/our-research-investigators/mollica-luigina. html Moroy, Tarik Institut de recherches cliniques de U. Montréal QC Stem cells— Cancer— CRC in www.ircm.qc.ca/microsites/moroy/en/ [email protected] Montréal hematopoietic hematological Hematopoiesis and Immune Cell Differentiation Morris, Quaid The Donnelly Centre, Banting and U. Toronto ON Stem cells—embryonic Various No thedonnellycentre.utoronto.ca/members/quaid_ [email protected] Best Department of Medical Research morris.html Morshead, Cindi U. Toronto ON Stem cells—neural Neurological, other No www.utoronto.ca/morsheadlab/ [email protected]

79 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3a. Cont’d universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Pang, Stephen Queen’s U. ON Stem cells—embryonic Cardiology No anatomy.queensu.ca/faculty/pang.cfm [email protected]

Paquin, Joanne U. Québec à QC Stem cells—various Musculoskeletal No www.biomed.uqam.ca/spip.php?rubrique60 [email protected] Montréal embryonic, adult Parise, Gianni McMaster U. ON Stem cells—muscle Musculoskeletal No www.science.mcmaster.ca/kinesiology/people/ [email protected] faculty/291-Gianni Parise.html Park, Edward U. Victoria BC Technology—stem Various No N/A [email protected] cells—cell sorting Pasumarthi, Kishore Babu S. Dalhousie U. NS Stem cells—cardiac Cardiology No pharmacology.medicine.dal.ca/about/people/faculty_ [email protected] progenitor detail.cfm?ID_People=105 Pelletier, Marc New Brunswick Heart Centre New Brunswick NB Stem cells— Cardiology No www.ctsnet.org/home/mpelletier [email protected] Heart Centre mesenchymal Perkins, Theodore Sprott Center for Stem Cell Research, U. Ottawa ON Stem cells—various— Various No www.perkinslab.ca/ [email protected] Ottawa Health Research Institute unspecifi ed Pilarski, Linda U. Alberta AB Stem cells—cancer Cancer—multiple CRC in www.oncology.med.ualberta.ca/faculty/ [email protected] myeloma Biomedical facultymember.cfm?id=24 Nanotechnology Pilliar, Robert U. Toronto ON Biomaterials; Tissue Musculoskeletal— No www.utoronto.ca/dentistry/facultyresearch/ [email protected] engineering bone; Dental facultyprofi les/pilliar_robert.html Pilon, Nicolas U. Québec à QC Stem cells—embryonic Neurological No www.biomed.uqam.ca/spip.php?rubrique87/ [email protected] Montréal Piret, James Michael Smith Laboratories U. British BC Technology— Various No www.msl.ubc.ca/faculty/piret [email protected] Columbia stem cells, incl. hematopoietic—high throughput analysis; Bioprocessing—cell culture Podor, Thomas iCapture U. British BC Stem cells— Cardiology No www.icapture.ubc.ca/who/who_bios_tom_podor. [email protected] Columbia hematopoietic (bone shtml marrow) Post, Martin Hospital for Sick Children U. Toronto ON Stem cells—embryonic Respiratory No www.sickkids.ca/AboutSickKids/Directory/People/P/ [email protected] Martin-Post.html Postovit, Lynne-Marie U. Western ON Stem cells— Cancer No www.uwo.ca/anatomy/department/postovitl/ [email protected] Ontario unspecifi ed lpostovit.html Pouliot, Roxane LOEX U. Laval QC Tissue engineering; Musculoskeletal No www.pha.ulaval.ca/sgc/pid/4929 [email protected] Biomaterials Prakash, Satya McGill U. QC Biomaterials; Tissue Cancer No www.bmed.mcgill.ca/BTCTRL/ [email protected] engineering Prato, Frank Lawson Health Research Institute, U. Western ON Stem cells—adult— Cardiology No www.uwo.ca/radnuc/radiologists/prato.html [email protected] London Health Sciences Centre Ontario endothelial progenitor Puri, Mira Sunnybrook Research Institute U. Toronto ON Stem cells—embryonic Embryogenesis No medbio.utoronto.ca/faculty/puri.html [email protected]

Putnins, Edward U. British BC Stem cells—bone Musculoskeletal No www.dentistry.ubc.ca/directory/faculty/detail. [email protected] Columbia marrow asp?user_id=24&from_directory=1 Puymirat, Jack U. Laval QC Stem cells—amniotic Mysculoskeletal No jpuymiratlab.crchul.ulaval.ca/ [email protected] myotonic dystrophy Qayumi, Karim Vancouver Coastal Health Research U. British BC Stem cells—bone Cardiology No www.researchers.vchri.ca/s/Researchers. [email protected] Institute Columbia marrow asp?ReportID=40705&_Type=Researchers- Database&_Title=Qayumi-Dr.-A.-Karim

80 appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER 3

universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Pang, Stephen Queen’s U. ON Stem cells—embryonic Cardiology No anatomy.queensu.ca/faculty/pang.cfm [email protected]

81 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3a. Cont’d universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Quinn, Thomas McGill U. QC Tissue engineering Musculoskeletal— CRC in Soft people.mcgill.ca/thomas.quinn/ [email protected] cartilage, ligaments Tissue Biophysics Radisic, Milica U. Toronto ON Tissue engineering— Cardiology No www.labs.chem-eng.utoronto.ca/radisic/principal- [email protected] scaffolds, cells; Stem investigator/ cells—angiogenic progenitor Rafuse, Victor Dalhousie U. NS Stem cells— Neurological, including No www.anatomy.dal.ca/Rafuse/index.htm [email protected] pluripotent— Parkinson’s, ALS embryonic, induced pluripotent; Neural Rajotte, Raymond V. U. Alberta AB Stem cells— Metabolic—diabetes No www.adi.med.ualberta.ca/Home/Research/ [email protected] pancreatic PrincipalInvestigators/Bio/rajotte.cfm Rak, Janusz The Research Institute of the McGill McGill U. QC Stem cells—cancer Cancer—brain No people.muhc.ca/janusz.rak/ [email protected] University Health Centre Ramsay, Bruce Queens U. ON Tissue engineering— Various No chemeng.queensu.ca/people/adjunct_Instructors/ [email protected] scaffolds bruce-ramsay/index.php Rancourt, Derrick U. Calgary AB Stem cells— Musculoskeletal No people.ucalgary.ca/~derlab/index.html [email protected] pluripotent— embryonic, induced pluripotent Raouf, Afshin Cancer Care Manitoba—Institute of U. Manitoba MB Stem cells—cancer Cancer—breast No www.umanitoba.ca/institutes/manitoba_institute_ [email protected] Cell Biology cell_biology/MICB/Rauof Afshin.htm Rastegar, Mojgan U. Manitoba MB Stem cells— Neurological, No umanitoba.ca/faculties/medicine/units/biochem/ [email protected] pluripotent—induced cancer—brain faculty/facultylists.html pluripotent, embryonic Reilly, Raymond Matthew U. Toronto ON Stem cells—cancer Cancer—leukemia No /www.uhnresearch.ca/researchers/profi le. [email protected] php?lookup=5062 Reinhardt, Dieter McGill U. QC Tissue engineering— Musculoskeletal CRC in www.mcgill.ca/dentistry/research/reinhardt/ [email protected] biomaterials, cells Extracellular Matrix Biology Reudelhuber, Timothy Luther Institut de recherches cliniques de U. Montréal QC Stem cells— Cardiovascular No www.medicine.mcgill.ca/expmed/staff/reudelhuber_ [email protected] Montréal unspecifi ed timothy.htm Rivest, Serge Centre hospitalier de l’Université Laval U. Laval QC Stem cells—bone Neurological No www.crchuq.ulaval.ca/en/research/researchers/4681 [email protected] marrow Robaire, Bernard McGill U. QC Stem cells—germline Reproduction—male; No www.medicine.mcgill.ca/pharma/robairelab/ [email protected] Other Robert, François Institut de recherches cliniques de U. Montréal QC Stem cells— Hematological No www.ircm.qc.ca/microsites/francoisrobert/en/ [email protected] Montréal hematopoietic Rogers, Ian Samuel Lunenfeld Research Institute, U. Toronto ON Stem cells—various— Various, including No www.lunenfeld.ca/researchers/rogers [email protected] Mount Sinai Hospital cord blood, induced diabetes pluripotent, bone marrow Rosenberg, Lawrence The Research Institute of the McGill McGill U. QC Stem cells— Metabolic—diabetes No www.montreal-diabetes-research-center.org/en/ [email protected] University Health Centre pancreatic rosenberg/rosenberg.asp Roskams, Jane U. British BC Stem cells—neural Neurological— No www.zoology.ubc.ca/person/roskams [email protected] Columbia olfactory Rossant, Janet Hospital for Sick Children U. Toronto ON Stem cells—embryonic Embryogenesis Lombard www.sickkids.ca/aboutsickkids/directory/people/r/ [email protected] Insurance Chair janet-rossant.html

82 appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER 3

universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Quinn, Thomas McGill U. QC Tissue engineering Musculoskeletal— CRC in Soft people.mcgill.ca/thomas.quinn/ [email protected] cartilage, ligaments Tissue Biophysics Radisic, Milica U. Toronto ON Tissue engineering— Cardiology No www.labs.chem-eng.utoronto.ca/radisic/principal- [email protected] scaffolds, cells; Stem investigator/ cells—angiogenic progenitor Rafuse, Victor Dalhousie U. NS Stem cells— Neurological, including No www.anatomy.dal.ca/Rafuse/index.htm [email protected] pluripotent— Parkinson’s, ALS embryonic, induced pluripotent; Neural Rajotte, Raymond V. U. Alberta AB Stem cells— Metabolic—diabetes No www.adi.med.ualberta.ca/Home/Research/ [email protected] pancreatic PrincipalInvestigators/Bio/rajotte.cfm Rak, Janusz The Research Institute of the McGill McGill U. QC Stem cells—cancer Cancer—brain No people.muhc.ca/janusz.rak/ [email protected] University Health Centre Ramsay, Bruce Queens U. ON Tissue engineering— Various No chemeng.queensu.ca/people/adjunct_Instructors/ [email protected] scaffolds bruce-ramsay/index.php Rancourt, Derrick U. Calgary AB Stem cells— Musculoskeletal No people.ucalgary.ca/~derlab/index.html [email protected] pluripotent— embryonic, induced pluripotent Raouf, Afshin Cancer Care Manitoba—Institute of U. Manitoba MB Stem cells—cancer Cancer—breast No www.umanitoba.ca/institutes/manitoba_institute_ [email protected] Cell Biology cell_biology/MICB/Rauof Afshin.htm Rastegar, Mojgan U. Manitoba MB Stem cells— Neurological, No umanitoba.ca/faculties/medicine/units/biochem/ [email protected] pluripotent—induced cancer—brain faculty/facultylists.html pluripotent, embryonic Reilly, Raymond Matthew U. Toronto ON Stem cells—cancer Cancer—leukemia No /www.uhnresearch.ca/researchers/profi le. [email protected] php?lookup=5062 Reinhardt, Dieter McGill U. QC Tissue engineering— Musculoskeletal CRC in www.mcgill.ca/dentistry/research/reinhardt/ [email protected] biomaterials, cells Extracellular Matrix Biology Reudelhuber, Timothy Luther Institut de recherches cliniques de U. Montréal QC Stem cells— Cardiovascular No www.medicine.mcgill.ca/expmed/staff/reudelhuber_ [email protected] Montréal unspecifi ed timothy.htm Rivest, Serge Centre hospitalier de l’Université Laval U. Laval QC Stem cells—bone Neurological No www.crchuq.ulaval.ca/en/research/researchers/4681 [email protected] marrow Robaire, Bernard McGill U. QC Stem cells—germline Reproduction—male; No www.medicine.mcgill.ca/pharma/robairelab/ [email protected] Other Robert, François Institut de recherches cliniques de U. Montréal QC Stem cells— Hematological No www.ircm.qc.ca/microsites/francoisrobert/en/ [email protected] Montréal hematopoietic Rogers, Ian Samuel Lunenfeld Research Institute, U. Toronto ON Stem cells—various— Various, including No www.lunenfeld.ca/researchers/rogers [email protected] Mount Sinai Hospital cord blood, induced diabetes pluripotent, bone marrow Rosenberg, Lawrence The Research Institute of the McGill McGill U. QC Stem cells— Metabolic—diabetes No www.montreal-diabetes-research-center.org/en/ [email protected] University Health Centre pancreatic rosenberg/rosenberg.asp Roskams, Jane U. British BC Stem cells—neural Neurological— No www.zoology.ubc.ca/person/roskams [email protected] Columbia olfactory Rossant, Janet Hospital for Sick Children U. Toronto ON Stem cells—embryonic Embryogenesis Lombard www.sickkids.ca/aboutsickkids/directory/people/r/ [email protected] Insurance Chair janet-rossant.html

83 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3a. Cont’d universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Rossi, Fabio Biomedical Research Centre U. British BC Stem cells— Various CRC in www.brc.ubc.ca/drupal5/node/73 [email protected] Columbia hematopoietic Regenerative Medicine (previously) Rottapel, Robert Ontario Cancer Institute, University U. Toronto ON Stem cells— Various No www.uhnres.utoronto.ca/researchers/profi le. [email protected] Health Network hematopoietic php?lookup=5182 Roy, Denis-Claude Centre de recherche de l’Hôpital U. Montréal QC Stem cells—cancer Cancer—leukemia No recherche.maisonneuve-rosemont.org/en-ca/ [email protected] Maisonneuve-Rosemont research/our-research-investigators/roy-denis- claude.html Roy, Jean Centre de recherche de l’Hôpital U. Montréal QC Stem cells— Cancer—leukemia Chair www.sct-hmr.org/en/jroy.php [email protected] Maisonneuve-Rosemont hematopoietic Industrielle— Alliance/ Université de Montréal Foundation on Leukemia Research Rudnicki, Michael Sprott Centre for Stem Cell Research, U. Ottawa ON Stem cells—various— Various, incl. CRC in Molecular www.ohri.ca/profi les/rudnicki.asp [email protected] Ottawa Hospital Research Institute embryonic, muscle, neuromuscular Genetics other adult Ruel, Marc University of Ottawa Heart Institute U. Ottawa ON Stem cells—various— Cardiology Cardiac Surgery www.ottawaheart.ca/misc/marc-ruel.htm [email protected] mesenchymal and Research Chair endothelial progenitor; Tissue engineering Sabourin, Luc Ottawa Hospital Research Institute U. Ottawa ON Stem cells—various— Various No www.ohri.ca/profi les/sabourin_summ.asp [email protected] embryonic, adult Santamaria, Pere U. Calgary AB Stem cells—embryonic Various, incl. No medicine.ucalgary.ca/research/chairs/santamaria/cv [email protected] immunological, metabolic—diabetes Santerre, Paul U. Toronto ON Tissue engineering— Cardiovascular No www.utoronto.ca/dentistry/facultyresearch/ [email protected] biomaterials, cells facultyprofi les/santerre.html [email protected] Sauvageau, Guy Institute for Research in Immunology U. Montréal QC Stem cells—various— Cancer— CRC in the www.iric.ca/Recherche/Chercheurs/Sauvageau_G. [email protected] and Cancer hematopoietic, hematological; Other Molecular html embryonic Genetics of Normal and Cancer Cells Savard, Pierre U. Laval QC Stem cells—muscle Various No www.crchuq.ulaval.ca/recherche/chercheurs/4641 [email protected]

Schimmer, Aaron Ontario Cancer Institute, University U. Toronto ON Stem cells—cancer Cancer—leukemia No www.uhnresearch.ca/researchers/profi le. [email protected] Health Network php?lookup=5351 Schrader, John W. Biomedical Research Centre U. British BC Stem cells— Immunological— No www.brc.ubc.ca/drupal5/node/36 [email protected] Columbia hematopoietic immunodefi ciency Schuh, Andre Ontario Cancer Institute, University U. Toronto ON Stem cells—embryonic Hematological— No medbio.utoronto.ca/faculty/schuh.html [email protected] Health Network hemophilia Schultz, Kirk Child & Family Research Institute U. British BC Stem cells— Cancer—leukemia No www.cfri.ca/our_research/researchers/search_ [email protected] Columbia hematopoietic researchers/researcher_detail.asp?ID=119 Schuurmans, Carol Associated with Hotchkiss Brain U. Calgary AB Stem cells— Neurological—stroke, No www.ucalgary.ca/bmb/schuurmans [email protected] Institute unspecifi ed spinal cord injury, eye

84 appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER 3

universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Rossi, Fabio Biomedical Research Centre U. British BC Stem cells— Various CRC in www.brc.ubc.ca/drupal5/node/73 [email protected] Columbia hematopoietic Regenerative Medicine (previously) Rottapel, Robert Ontario Cancer Institute, University U. Toronto ON Stem cells— Various No www.uhnres.utoronto.ca/researchers/profi le. [email protected] Health Network hematopoietic php?lookup=5182 Roy, Denis-Claude Centre de recherche de l’Hôpital U. Montréal QC Stem cells—cancer Cancer—leukemia No recherche.maisonneuve-rosemont.org/en-ca/ [email protected] Maisonneuve-Rosemont research/our-research-investigators/roy-denis- claude.html Roy, Jean Centre de recherche de l’Hôpital U. Montréal QC Stem cells— Cancer—leukemia Chair www.sct-hmr.org/en/jroy.php [email protected] Maisonneuve-Rosemont hematopoietic Industrielle— Alliance/ Université de Montréal Foundation on Leukemia Research Rudnicki, Michael Sprott Centre for Stem Cell Research, U. Ottawa ON Stem cells—various— Various, incl. CRC in Molecular www.ohri.ca/profi les/rudnicki.asp [email protected] Ottawa Hospital Research Institute embryonic, muscle, neuromuscular Genetics other adult Ruel, Marc University of Ottawa Heart Institute U. Ottawa ON Stem cells—various— Cardiology Cardiac Surgery www.ottawaheart.ca/misc/marc-ruel.htm [email protected] mesenchymal and Research Chair endothelial progenitor; Tissue engineering Sabourin, Luc Ottawa Hospital Research Institute U. Ottawa ON Stem cells—various— Various No www.ohri.ca/profi les/sabourin_summ.asp [email protected] embryonic, adult Santamaria, Pere U. Calgary AB Stem cells—embryonic Various, incl. No medicine.ucalgary.ca/research/chairs/santamaria/cv [email protected] immunological, metabolic—diabetes Santerre, Paul U. Toronto ON Tissue engineering— Cardiovascular No www.utoronto.ca/dentistry/facultyresearch/ [email protected] biomaterials, cells facultyprofi les/santerre.html [email protected] Sauvageau, Guy Institute for Research in Immunology U. Montréal QC Stem cells—various— Cancer— CRC in the www.iric.ca/Recherche/Chercheurs/Sauvageau_G. [email protected] and Cancer hematopoietic, hematological; Other Molecular html embryonic Genetics of Normal and Cancer Cells Savard, Pierre U. Laval QC Stem cells—muscle Various No www.crchuq.ulaval.ca/recherche/chercheurs/4641 [email protected]

85 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3a. Cont’d universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Sefton, Michael The Donnelly Centre U. Toronto ON Tissue engineering— Various Michael E. alumni.utoronto.ca/s/731/index. [email protected] biomaterials, cells Charles Chair aspx?sid=731&gid=36&pgid=2135; tdccbr.med. in Chemical utoronto.ca/members/michael_sefton.html Engineering Seguin, Cheryle U. Western ON Stem cells—various— Various, incl. No www.uwo.ca/physpharm/faculty/seguin_cheryle.html cheryle.seguin@ schulich.uwo.ca Ontario pluripotent, neural metabolic, musculoskeletal, embryogenesis Sen, Arindom U. Calgary AB Bioprocessing—stem Various No www.schulich.ucalgary.ca/chemical/ArindomSen [email protected] cells—adult Shaw, Patricia Ann Ontario Cancer Institute, University U. Toronto ON Stem cells— Cancer No www.uhnres.utoronto.ca/researchers/profi le. [email protected] Health Network mesenchymal php?lookup=5485 Sheardown, Heather McMaster U. ON Biomaterials Various—eye, No chemeng.mcmaster.ca/sheardown.html [email protected] cardiovascular Shoichet, Molly McEwen Centre for Regenerative U. Toronto ON Tissue engineering: Various—neurological: CRC in Tissue www.mcewencentre.com/bio_shoichet.asp [email protected] Medicine, Toronto General Research Biomaterials— Spinal cord injury, eye; Engineering [email protected] Institute, University Health Network scaffolds; Stem cells Cancer Simmons, Craig U. Toronto ON Technology— Various—cardiology; CRC in www.mie.utoronto.ca/staff/profi les/simmons/ [email protected] high throughput Musculoskeletal— Mechanobiology screening; Stem bone cells—mesenchymal, cord blood; Tissue engineering Singh, Sheila Stem Cell and Cancer Research McMaster U. ON Stem cells—cancer Cancer—brain CRC in Human sccri.mcmaster.ca/singh_sheila.html [email protected] Institute Cancer Stem Cell Biology Skerjanc, Ilona Sylvia U. Ottawa ON Stem cells—embryonic Various— No www.med.uottawa.ca/bmi/eng/skerjanc.html [email protected] cardiovascular, musculoskeletal Slack, Ruth Ottawa Hospital Research Institute U. Ottawa ON Stem cells— Neurological No www.med.uottawa.ca/ruthslack/ [email protected] unspecifi ed Smith, Clayton Terry Fox Laboratoy, BC Cancer U. British BC Stem cells— Cancer— CRC in Cell www.terryfoxlab.ca/people/csmith/clayton.aspx [email protected] Agency Columbia hematopoietic hematological Therapies Smith, Lawrence C. U. Montréal QC Stem cells—embryonic Embryogenesis No www.medvet.umontreal.ca/crra/index.php/ [email protected] chercheurs/lawrence-c-smith Song, Kevin Vancouver Coastal Health Research U. British BC Stem cells— Cancer—lymphoma No www.vch.ca/bmt/public/referral/attending.htmlwww. [email protected] Institute Columbia hematopoietic leukemiabmtprogram.org/general_information/ about_us/our_doctors/song.html Stanford, William U. Toronto ON Stem cells—various— Various, incl. CRC in Stem Cell www.wlstanfordlab.com/index.php [email protected] pluripotent—induced musculoskeletal— Bioengineering pluripotent, embryonic; osteoporosis and Functional Mesenchymal Genomics Stanisz, Greg Sunnybrook Research Institute U. Toronto ON Stem cells— Neurological No medbio.utoronto.ca/faculty/stanisz.html [email protected] unspecifi ed Stewart, Alexandre University of Ottawa Heart Institute U. Ottawa ON Stem cells—cardiac Cardiology No www.ottawaheart.ca/misc/alexandre-stewart.htm [email protected]

Stewart, Duncan Sprott Centre for Stem Cell Research, U. Ottawa ON Stem cells—adult Cardiovascular No www.ohri.ca/profi les/stewart.asp [email protected] Ottawa Health Research Institute Stifani, Stefano Montreal Neurological Institute McGill U. QC Stem cells—embryonic Neurological—ALS No www.mni.mcgill.ca/neuro_team/neuronal_survival/ [email protected] stefano_stifani/ 86 appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER 3

universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Sefton, Michael The Donnelly Centre U. Toronto ON Tissue engineering— Various Michael E. alumni.utoronto.ca/s/731/index. [email protected] biomaterials, cells Charles Chair aspx?sid=731&gid=36&pgid=2135; tdccbr.med. in Chemical utoronto.ca/members/michael_sefton.html Engineering Seguin, Cheryle U. Western ON Stem cells—various— Various, incl. No www.uwo.ca/physpharm/faculty/seguin_cheryle.html cheryle.seguin@ schulich.uwo.ca Ontario pluripotent, neural metabolic, musculoskeletal, embryogenesis Sen, Arindom U. Calgary AB Bioprocessing—stem Various No www.schulich.ucalgary.ca/chemical/ArindomSen [email protected] cells—adult Shaw, Patricia Ann Ontario Cancer Institute, University U. Toronto ON Stem cells— Cancer No www.uhnres.utoronto.ca/researchers/profi le. [email protected] Health Network mesenchymal php?lookup=5485 Sheardown, Heather McMaster U. ON Biomaterials Various—eye, No chemeng.mcmaster.ca/sheardown.html [email protected] cardiovascular Shoichet, Molly McEwen Centre for Regenerative U. Toronto ON Tissue engineering: Various—neurological: CRC in Tissue www.mcewencentre.com/bio_shoichet.asp [email protected] Medicine, Toronto General Research Biomaterials— Spinal cord injury, eye; Engineering [email protected] Institute, University Health Network scaffolds; Stem cells Cancer Simmons, Craig U. Toronto ON Technology— Various—cardiology; CRC in www.mie.utoronto.ca/staff/profi les/simmons/ [email protected] high throughput Musculoskeletal— Mechanobiology screening; Stem bone cells—mesenchymal, cord blood; Tissue engineering Singh, Sheila Stem Cell and Cancer Research McMaster U. ON Stem cells—cancer Cancer—brain CRC in Human sccri.mcmaster.ca/singh_sheila.html [email protected] Institute Cancer Stem Cell Biology Skerjanc, Ilona Sylvia U. Ottawa ON Stem cells—embryonic Various— No www.med.uottawa.ca/bmi/eng/skerjanc.html [email protected] cardiovascular, musculoskeletal Slack, Ruth Ottawa Hospital Research Institute U. Ottawa ON Stem cells— Neurological No www.med.uottawa.ca/ruthslack/ [email protected] unspecifi ed Smith, Clayton Terry Fox Laboratoy, BC Cancer U. British BC Stem cells— Cancer— CRC in Cell www.terryfoxlab.ca/people/csmith/clayton.aspx [email protected] Agency Columbia hematopoietic hematological Therapies Smith, Lawrence C. U. Montréal QC Stem cells—embryonic Embryogenesis No www.medvet.umontreal.ca/crra/index.php/ [email protected] chercheurs/lawrence-c-smith Song, Kevin Vancouver Coastal Health Research U. British BC Stem cells— Cancer—lymphoma No www.vch.ca/bmt/public/referral/attending.htmlwww. [email protected] Institute Columbia hematopoietic leukemiabmtprogram.org/general_information/ about_us/our_doctors/song.html Stanford, William U. Toronto ON Stem cells—various— Various, incl. CRC in Stem Cell www.wlstanfordlab.com/index.php [email protected] pluripotent—induced musculoskeletal— Bioengineering pluripotent, embryonic; osteoporosis and Functional Mesenchymal Genomics Stanisz, Greg Sunnybrook Research Institute U. Toronto ON Stem cells— Neurological No medbio.utoronto.ca/faculty/stanisz.html [email protected] unspecifi ed Stewart, Alexandre University of Ottawa Heart Institute U. Ottawa ON Stem cells—cardiac Cardiology No www.ottawaheart.ca/misc/alexandre-stewart.htm [email protected]

3a. Cont’d universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Sun, Yu U. Toronto ON Tissue engineering— Various CRC in Micro and amnl.mie.utoronto.ca%20/ [email protected] screening Nano Engineering Systems Suuronen, Erik University of Ottawa Heart Institute U. Ottawa ON Stem cells— Cardiology No www.ottawaheart.ca/misc/erik-suuronen.htm [email protected] mesenchymal and endothelial progenitor; Biomaterials— scaffolds Tabori, Uri Hospital for Sick Children U. Toronto ON Stem cells—cancer Cancer—brain No www.sickkids.ca/aboutsickkids/directory/people/t/ [email protected] uri-tabori.html Tabrizian, Maryam McGill U. QC Biomaterials; Tissue Cardiovascular No /www.bmed.mcgill.ca/tabrizian/people_pages/ [email protected] engineering— maryam.htm scaffolds Tanentzapf, Guy U. British BC Stem cells— Musculoskeletal No celldevelopment.ubc.ca/research/researchers/dr- [email protected] Columbia unspecifi ed guy-tanentzapf/ Tang, Damu St. Joseph’s Hospital (Hamilton) McMaster U. ON Stem cells—cancer Cancer—prostate No /www.hamiltonkidneyresearch.ca/page.aspx?menu= [email protected] 39&app=173&cat1=433&tp=2&lk=no Tanner, Scott U. Toronto ON Technology—Stem Cancer No www.chem.utoronto.ca/ppl/faculty_profi le. [email protected] cells—cancer; High php?id=186 throughput technology Tannock, Ian Frederick Ontario Cancer Institute, University U. Toronto ON Stem cells—cancer Cancer No www.uhnresearch.ca/researchers/profi le. [email protected] Health Network php?lookup=5941 Tator, Charles Toronto General Research Institute, U. Toronto ON Stem cells—adult Neurological—spinal No www.uhnresearch.ca/researchers/profi le. [email protected] University Health Network cord injury php?lookup=5950 Tetzlaff, Wolfram U. British BC Stem cells— Neurological—spinal No www.zoology.ubc.ca/person/~tetzlaff www.zoology.ubc.ca/person/~tetzlaff Columbia unspecifi ed cord injury Thebaud, Bernard U. Alberta AB Stem cells—lung Respiratory CRC in www.physiology.ualberta.ca/home/People/ [email protected] Translational Academic/thebaud.cfm Lung and Vascular Development Biology Tian, Ganghong (Hong) Associated with National Research U. Manitoba MB Stem cells—fat Cardiology No www.nrc-cnrc.gc.ca/eng/people/tian_ [email protected] Council of Canada, Institute for ganghong_6253.html Biological Sciences Till, Jim Ontario Cancer Institute, University U. Toronto ON Stem cells— Cancer No myprofi le.cos.com/tillj16 [email protected] Health Network hematopoietic Toyserkani, Ehsan U. Waterloo ON Biomaterials— Musculoskeletal No www.mme.uwaterloo.ca/people/info.php?id=70 [email protected] scaffolds Toze, Cynthia BC Cancer Agency U. British BC Stem cells—bone Cancer— No www.leukemiabmtprogram.org/general_information/ [email protected] Columbia marrow hematological about_us/our_doctors/toze.html Tran, Simon McGill U. QC Stem cells—bone Dental CRC in www.mcgill.ca/dentistry/research/tran/ [email protected] marrow Craniofacial Stem Cells and Tissue Engineering Tredget, Edward Eric U. Alberta AB Stem cells—bone Cutaneous No www.surgery.ualberta.ca/Home/Divisions/surgical_ [email protected] marrow research.cfm Tremblay, Jacques Centre hospitalier de l’Université Laval U. Laval QC Stem cells—bone Musculoskeletal— No www.vrr.ulaval.ca/bd/chercheur/fi che/228703.html [email protected] marrow muscular dystrophy

88 appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER 3

universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Sun, Yu U. Toronto ON Tissue engineering— Various CRC in Micro and amnl.mie.utoronto.ca%20/ [email protected] screening Nano Engineering Systems Suuronen, Erik University of Ottawa Heart Institute U. Ottawa ON Stem cells— Cardiology No www.ottawaheart.ca/misc/erik-suuronen.htm [email protected] mesenchymal and endothelial progenitor; Biomaterials— scaffolds Tabori, Uri Hospital for Sick Children U. Toronto ON Stem cells—cancer Cancer—brain No www.sickkids.ca/aboutsickkids/directory/people/t/ [email protected] uri-tabori.html Tabrizian, Maryam McGill U. QC Biomaterials; Tissue Cardiovascular No /www.bmed.mcgill.ca/tabrizian/people_pages/ [email protected] engineering— maryam.htm scaffolds Tanentzapf, Guy U. British BC Stem cells— Musculoskeletal No celldevelopment.ubc.ca/research/researchers/dr- [email protected] Columbia unspecifi ed guy-tanentzapf/ Tang, Damu St. Joseph’s Hospital (Hamilton) McMaster U. ON Stem cells—cancer Cancer—prostate No /www.hamiltonkidneyresearch.ca/page.aspx?menu= [email protected] 39&app=173&cat1=433&tp=2&lk=no Tanner, Scott U. Toronto ON Technology—Stem Cancer No www.chem.utoronto.ca/ppl/faculty_profi le. [email protected] cells—cancer; High php?id=186 throughput technology Tannock, Ian Frederick Ontario Cancer Institute, University U. Toronto ON Stem cells—cancer Cancer No www.uhnresearch.ca/researchers/profi le. [email protected] Health Network php?lookup=5941 Tator, Charles Toronto General Research Institute, U. Toronto ON Stem cells—adult Neurological—spinal No www.uhnresearch.ca/researchers/profi le. [email protected] University Health Network cord injury php?lookup=5950 Tetzlaff, Wolfram U. British BC Stem cells— Neurological—spinal No www.zoology.ubc.ca/person/~tetzlaff www.zoology.ubc.ca/person/~tetzlaff Columbia unspecifi ed cord injury Thebaud, Bernard U. Alberta AB Stem cells—lung Respiratory CRC in www.physiology.ualberta.ca/home/People/ [email protected] Translational Academic/thebaud.cfm Lung and Vascular Development Biology Tian, Ganghong (Hong) Associated with National Research U. Manitoba MB Stem cells—fat Cardiology No www.nrc-cnrc.gc.ca/eng/people/tian_ [email protected] Council of Canada, Institute for ganghong_6253.html Biological Sciences Till, Jim Ontario Cancer Institute, University U. Toronto ON Stem cells— Cancer No myprofi le.cos.com/tillj16 [email protected] Health Network hematopoietic Toyserkani, Ehsan U. Waterloo ON Biomaterials— Musculoskeletal No www.mme.uwaterloo.ca/people/info.php?id=70 [email protected] scaffolds Toze, Cynthia BC Cancer Agency U. British BC Stem cells—bone Cancer— No www.leukemiabmtprogram.org/general_information/ [email protected] Columbia marrow hematological about_us/our_doctors/toze.html Tran, Simon McGill U. QC Stem cells—bone Dental CRC in www.mcgill.ca/dentistry/research/tran/ [email protected] marrow Craniofacial Stem Cells and Tissue Engineering Tredget, Edward Eric U. Alberta AB Stem cells—bone Cutaneous No www.surgery.ualberta.ca/Home/Divisions/surgical_ [email protected] marrow research.cfm Tremblay, Jacques Centre hospitalier de l’Université Laval U. Laval QC Stem cells—bone Musculoskeletal— No www.vrr.ulaval.ca/bd/chercheur/fi che/228703.html [email protected] marrow muscular dystrophy

89 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3a. Cont’d universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Tremblay, Michel L. McGill U. QC Stem cells— Cardiology No www.mcgill.ca/biochemistry/department/faculty/ [email protected] hematopoietic tremblay/ Trigatti, Bernardo Louis McMaster U. ON Stem cells—bone Cardiovascular No www.science.mcmaster.ca/biochem/faculty/trigatti/ [email protected] marrow Tropepe, Vince U. Toronto ON Stem cells—neural Neurological No www.utoronto.ca/tropepe-lab/people.html [email protected] development Tsai, Eve Sprott Centre for Stem Cell Research, U. Ottawa ON Stem cells— Neurological—spinal No www.ohri.ca/profi les/tsai.asp [email protected] Ottawa Health Research Institute unspecifi ed cord injury Tsilfi dis, Catherine Sprott Centre for Stem Cell Research, U. Ottawa ON Stem cells—adult Eye Don and Joy www.ohri.ca/profi les/tsilfi dis.asp ctsilfi [email protected] Ottawa Health Research Institute Maclaren Chair for Vision Research (previously) Tufenkji, Nathalie McGill U. QC Biomaterials— Musculoskeletal CRC in people.mcgill.ca/nathalie.tufenkji/ [email protected] scaffolds Biocolloids and Surfaces Turksen, Kursad Sprott Centre for Stem Cell Research, U. Ottawa ON Stem cells—various— Cutaneous No www.ohri.ca/profi les/turksen.asp [email protected] Ottawa Health Research Institute embryonic, epidermal Turner, Robin Michael Smith Laboratories U. British BC Technology—Stem Various No www.msl.ubc.ca/faculty/turner [email protected] Columbia cells—embryonic; Analysis, production Tyndale, Rachel U. Toronto ON Stem cells— Various CRC in Pharma- www.pharmtox.utoronto.ca/faculty/directory/tyndale. [email protected] pluripotent— cogenetics htm embryonic, induced pluripotent Underhill, Michael U. British BC Stem cells—cord Musculoskeletal No www.cellphys.ubc.ca/faculty_pages/underhill.html [email protected] Columbia blood Unsworth, Larry U. Alberta AB Biomaterials— Various No www.cme.engineering.ualberta.ca/en/FacultyStaff/ [email protected] scaffolds FacultyAcademicStaff/Unsworth.aspx van der Kooy, Derek McEwen Centre for Regenerative U. Toronto ON Stem cells—neural Neurological—brain; No medbio.utoronto.ca/faculty/vanderkooy.html [email protected] Medicine, Toronto General Research (incl. retinal) Eye Institute, University Health Network Vanderluit, Jacqueline Memorial U. NL Stem cells—neural Neurological No www.med.mun.ca/Medicine/Faculty/Vanderluit,- [email protected] Jackie.aspx Verchere, Bruce U. British BC Stem cells—adult Metabolic—diabetes No www.pathology.ubc.ca/NewPathology/Professor/ [email protected] Columbia Bruce_Verchere.html Veres, Teodor U. Laval QC Biomaterials; Tissue Cardiovascular No www.vrr.ulaval.ca/bd/chercheur/fi che/551399.html [email protected] engineering—cells Vermette, Patrick U. Sherbrooke QC Tissue engineering— Metabolic—diabetes No www.usherbrooke.ca/gchimiquebiotech/personnel/ [email protected] cell culture; professeurs/patrick-vermette/ Biomaterials— scaffolds Vincent, Michel U. Laval QC Stem cells—muscle Various— No www.vrr.ulaval.ca/bd/chercheur/fi che/4934.html [email protected] progenitor cardiovascular, musculoskeletal von Harsdorf, Rudiger McEwen Centre for Regenerative U. Toronto ON Regeneration—heart Cardiology No www.uhnresearch.ca/researchers/profi le. [email protected] Medicine, Toronto General Research php?lookup=10949 Institute, University Health Network

90 appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER 3

universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Tremblay, Michel L. McGill U. QC Stem cells— Cardiology No www.mcgill.ca/biochemistry/department/faculty/ [email protected] hematopoietic tremblay/ Trigatti, Bernardo Louis McMaster U. ON Stem cells—bone Cardiovascular No www.science.mcmaster.ca/biochem/faculty/trigatti/ [email protected] marrow Tropepe, Vince U. Toronto ON Stem cells—neural Neurological No www.utoronto.ca/tropepe-lab/people.html [email protected] development Tsai, Eve Sprott Centre for Stem Cell Research, U. Ottawa ON Stem cells— Neurological—spinal No www.ohri.ca/profi les/tsai.asp [email protected] Ottawa Health Research Institute unspecifi ed cord injury Tsilfi dis, Catherine Sprott Centre for Stem Cell Research, U. Ottawa ON Stem cells—adult Eye Don and Joy www.ohri.ca/profi les/tsilfi dis.asp ctsilfi [email protected] Ottawa Health Research Institute Maclaren Chair for Vision Research (previously) Tufenkji, Nathalie McGill U. QC Biomaterials— Musculoskeletal CRC in people.mcgill.ca/nathalie.tufenkji/ [email protected] scaffolds Biocolloids and Surfaces Turksen, Kursad Sprott Centre for Stem Cell Research, U. Ottawa ON Stem cells—various— Cutaneous No www.ohri.ca/profi les/turksen.asp [email protected] Ottawa Health Research Institute embryonic, epidermal Turner, Robin Michael Smith Laboratories U. British BC Technology—Stem Various No www.msl.ubc.ca/faculty/turner [email protected] Columbia cells—embryonic; Analysis, production Tyndale, Rachel U. Toronto ON Stem cells— Various CRC in Pharma- www.pharmtox.utoronto.ca/faculty/directory/tyndale. [email protected] pluripotent— cogenetics htm embryonic, induced pluripotent Underhill, Michael U. British BC Stem cells—cord Musculoskeletal No www.cellphys.ubc.ca/faculty_pages/underhill.html [email protected] Columbia blood Unsworth, Larry U. Alberta AB Biomaterials— Various No www.cme.engineering.ualberta.ca/en/FacultyStaff/ [email protected] scaffolds FacultyAcademicStaff/Unsworth.aspx van der Kooy, Derek McEwen Centre for Regenerative U. Toronto ON Stem cells—neural Neurological—brain; No medbio.utoronto.ca/faculty/vanderkooy.html [email protected] Medicine, Toronto General Research (incl. retinal) Eye Institute, University Health Network Vanderluit, Jacqueline Memorial U. NL Stem cells—neural Neurological No www.med.mun.ca/Medicine/Faculty/Vanderluit,- [email protected] Jackie.aspx Verchere, Bruce U. British BC Stem cells—adult Metabolic—diabetes No www.pathology.ubc.ca/NewPathology/Professor/ [email protected] Columbia Bruce_Verchere.html Veres, Teodor U. Laval QC Biomaterials; Tissue Cardiovascular No www.vrr.ulaval.ca/bd/chercheur/fi che/551399.html [email protected] engineering—cells Vermette, Patrick U. Sherbrooke QC Tissue engineering— Metabolic—diabetes No www.usherbrooke.ca/gchimiquebiotech/personnel/ [email protected] cell culture; professeurs/patrick-vermette/ Biomaterials— scaffolds Vincent, Michel U. Laval QC Stem cells—muscle Various— No www.vrr.ulaval.ca/bd/chercheur/fi che/4934.html [email protected] progenitor cardiovascular, musculoskeletal von Harsdorf, Rudiger McEwen Centre for Regenerative U. Toronto ON Regeneration—heart Cardiology No www.uhnresearch.ca/researchers/profi le. [email protected] Medicine, Toronto General Research php?lookup=10949 Institute, University Health Network

91 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3a. Cont’d universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail von Tigerstrom, Barbara U. Saskatchewan Sask Social science & SSH: Law No www.usask.ca/law/about_us/bio.php?id=19 [email protected] humanities Waddell, Thomas McEwen Centre for Regenerative U. Toronto ON Stem cells— Respiratory—lung No www.uhnresearch.ca/researchers/profi le. [email protected] Medicine, Toronto General Research mesenchymal transplant php?lookup=6315 Institute, University Health Network Waldman, Stephen Queens U. ON Tissue engineering— Musculoskeletal CRC in www.chemeng.queensu.ca/people/faculty/waldman/ [email protected] cell culture Engineering of Human Joints Walker, Gilbert Creighton U. Toronto ON Biomaterials Cardiovascular CRC in Molecular www.chem.utoronto.ca/~gwalker/ [email protected] Microscopy and Nanophotonic Devices Wall, Donna Cancer Care Manitoba U. Manitoba MB Stem cells— Cancer No www.cancercare.mb.ca/resource/File/Super_ [email protected] hematological Seven_Bios.pdf Wallace, Valerie Sprott Centre for Stem Cell Research, U. Ottawa ON Stem cells—retinal Eye No www.ohri.ca/profi les/wallace.asp [email protected] Ottawa Health Research Institute Walus, Konrad U. British BC Biomaterials— Various— No www.mina.ubc.ca/konradw [email protected] Columbia scaffolds musculoskeletal, cutaneous Wang, Chen U. Toronto ON Stem cells— Hematological— No icarus.med.utoronto.ca/patho/faculty. [email protected] hematopoietic anemia asp?FacultyID=233 Wang, Lisheng U. Ottawa ON Stem cells—embryonic Various No www.med.uottawa.ca/associations/oisb/members/ [email protected] member_lisheng_wang.htm Ward, Christopher Andrew Queen’s U. ON Stem cells— Cardiology No www.queensu.ca/cgi-bin/ph/whois.queensu. [email protected] mesenchymal ca?Query=deptcode=D922_34 Warnock, Garth Vancouver Coastal Health Research U. British BC Stem cells— Metabolic—diabetes No www.surgery.ubc.ca/faculty/gwarnock.html [email protected] Institute Columbia pancreatic (islet) Weisel, Richard Toronto General Research Institute, U. Toronto ON Tissue engineering: Cardiology No www.uhn.ca/media/faq/experts/research/res_exp_ [email protected] University Health Network Stem cells— weisel.asp transplantation Weiss, Samuel Associated with Hotchkiss Brain U. Calgary AB Stem cells—neural Neurological—brain, No www.ucalgary.ca/gdrg/sweiss.html [email protected] Institute olfactory Wells, Richard Alexander Sunnybrook Research Institute U. Toronto ON Stem cells— Cancer—leukemia No sunnybrook.ca/research/team/member. [email protected] hematopoietic asp?t=13&m=177&page=187 Wells, Sarah Dalhousie U. NS Tissue engineering— Cardiovascular No bme.medicine.dal.ca/faculty/wells/ [email protected] scaffolds Wertheimer, Michel Robert École QC Biomaterials Various No www.polymtl.ca/recherche/rc/en/professeurs/ [email protected] polytechnique de details.php?NoProf=150 Montréal Whyne, Cari Sunnybrook Research Institute U. Toronto ON Tissue engineering Musculoskeletal No sunnybrook.ca/research/team/member. [email protected] asp?t=13&m=178&page=172 Wiper-Bergeron, Nadine Louise U. Ottawa ON Stem cells— Musculoskeletal No www.med.uottawa.ca/research/wiper-bergeronlab/ [email protected] mesenchymal Wong, Peggy Hospital for Sick Children U. Toronto ON Stem cells—cancer Cancer—leukemia No www.ontariodoctordirectory.ca/Toronto/Doctor- N/A Peggy-Pui-Chi-Wong-31836.html Woodgett, James Samuel Lunenfeld Research Institute, U. Toronto ON Stem cells—adult Various, incl. cancer, No www.lunenfeld.ca/researchers/woodgett [email protected] Mount Sinai Hospital metabolic—diabetes, neurological

92 appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER 3

universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail von Tigerstrom, Barbara U. Saskatchewan Sask Social science & SSH: Law No www.usask.ca/law/about_us/bio.php?id=19 [email protected] humanities Waddell, Thomas McEwen Centre for Regenerative U. Toronto ON Stem cells— Respiratory—lung No www.uhnresearch.ca/researchers/profi le. [email protected] Medicine, Toronto General Research mesenchymal transplant php?lookup=6315 Institute, University Health Network Waldman, Stephen Queens U. ON Tissue engineering— Musculoskeletal CRC in www.chemeng.queensu.ca/people/faculty/waldman/ [email protected] cell culture Engineering of Human Joints Walker, Gilbert Creighton U. Toronto ON Biomaterials Cardiovascular CRC in Molecular www.chem.utoronto.ca/~gwalker/ [email protected] Microscopy and Nanophotonic Devices Wall, Donna Cancer Care Manitoba U. Manitoba MB Stem cells— Cancer No www.cancercare.mb.ca/resource/File/Super_ [email protected] hematological Seven_Bios.pdf Wallace, Valerie Sprott Centre for Stem Cell Research, U. Ottawa ON Stem cells—retinal Eye No www.ohri.ca/profi les/wallace.asp [email protected] Ottawa Health Research Institute Walus, Konrad U. British BC Biomaterials— Various— No www.mina.ubc.ca/konradw [email protected] Columbia scaffolds musculoskeletal, cutaneous Wang, Chen U. Toronto ON Stem cells— Hematological— No icarus.med.utoronto.ca/patho/faculty. [email protected] hematopoietic anemia asp?FacultyID=233 Wang, Lisheng U. Ottawa ON Stem cells—embryonic Various No www.med.uottawa.ca/associations/oisb/members/ [email protected] member_lisheng_wang.htm Ward, Christopher Andrew Queen’s U. ON Stem cells— Cardiology No www.queensu.ca/cgi-bin/ph/whois.queensu. [email protected] mesenchymal ca?Query=deptcode=D922_34 Warnock, Garth Vancouver Coastal Health Research U. British BC Stem cells— Metabolic—diabetes No www.surgery.ubc.ca/faculty/gwarnock.html [email protected] Institute Columbia pancreatic (islet) Weisel, Richard Toronto General Research Institute, U. Toronto ON Tissue engineering: Cardiology No www.uhn.ca/media/faq/experts/research/res_exp_ [email protected] University Health Network Stem cells— weisel.asp transplantation Weiss, Samuel Associated with Hotchkiss Brain U. Calgary AB Stem cells—neural Neurological—brain, No www.ucalgary.ca/gdrg/sweiss.html [email protected] Institute olfactory Wells, Richard Alexander Sunnybrook Research Institute U. Toronto ON Stem cells— Cancer—leukemia No sunnybrook.ca/research/team/member. [email protected] hematopoietic asp?t=13&m=177&page=187 Wells, Sarah Dalhousie U. NS Tissue engineering— Cardiovascular No bme.medicine.dal.ca/faculty/wells/ [email protected] scaffolds Wertheimer, Michel Robert École QC Biomaterials Various No www.polymtl.ca/recherche/rc/en/professeurs/ [email protected] polytechnique de details.php?NoProf=150 Montréal Whyne, Cari Sunnybrook Research Institute U. Toronto ON Tissue engineering Musculoskeletal No sunnybrook.ca/research/team/member. [email protected] asp?t=13&m=178&page=172 Wiper-Bergeron, Nadine Louise U. Ottawa ON Stem cells— Musculoskeletal No www.med.uottawa.ca/research/wiper-bergeronlab/ [email protected] mesenchymal Wong, Peggy Hospital for Sick Children U. Toronto ON Stem cells—cancer Cancer—leukemia No www.ontariodoctordirectory.ca/Toronto/Doctor- N/A Peggy-Pui-Chi-Wong-31836.html Woodgett, James Samuel Lunenfeld Research Institute, U. Toronto ON Stem cells—adult Various, incl. cancer, No www.lunenfeld.ca/researchers/woodgett [email protected] Mount Sinai Hospital metabolic—diabetes, neurological

93 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3a. Cont’d universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Woodhouse, Kimberly Queen’s U. ON Tissue engineering— Cardiovascular No chemeng.queensu.ca/people/faculty/woodhouse/ [email protected] scaffolds, stem cells index.php Wouters, Bradley Ontario Cancer Institute, University U. Toronto ON Stem cells—cancer Cancer No www.uhnres.utoronto.ca/researchers/profi le. [email protected] Health Network php?lookup=27665 Wrana, Jeffrey Samuel Lunenfeld Research Institute, U. Toronto ON Technology—stem Cancer CRC in Systems www.lunenfeld.ca/researchers/Wrana [email protected] Mount Sinai Hospital cells—high throughput Biology; Mary analysis Janigan Research Chair in Molecular Cancer Therapeutics Wynder, Christopher McMaster U. ON Stem cells—embryonic Cancer CRC in Epigenetic fhs.mcmaster.ca/main/canada_chairs/epigenetic_ [email protected] Control of Stem control_of_stem_cells_chair.html Cells Yahia, L’Hocine École QC Biomaterials Musculoskeletal No www.polymtl.ca/recherche/rc/en/professeurs/ [email protected] polytechnique de details.php?NoProf=243 Montreal Yang, Xiang-Jiao McGill U. QC Stem cells—various— Aging No www.mcgill.ca/mog/research/yang/ [email protected] unspecifi ed Yip, Christopher The Donnelly Centre U. Toronto ON Stem cells— Various No biochemistry.utoronto.ca/yip/bch.html [email protected] hematopoietic Yong, Von Wee Associated with Hotchkiss Brain U. Calgary AB Stem cells— Neurological—multiple No www.hbi.ucalgary.ca/members/yong [email protected] Institute hematopoietic sclerosis Zackenhaus, Eldad U. Toronto ON Stem cells—cancer Cancer No medbio.utoronto.ca/faculty/zacksenhaus.html [email protected]

Zandstra, Peter McEwen Centre for Regenerative U. Toronto ON Stem cells—various Various, incl. CRC in Stem Cell stemcell.ibme.utoronto.ca/ [email protected] Medicine, University Health Network including embryonic, hematological Bioengineering and Institute of Biomaterials and hematopoietic Biomedical Engineering, Donnelly Centre Zhang, Ze U. Laval QC Tissue engineering— Various No www.crchuq.ulaval.ca/en/research/researchers/8491 [email protected] scaffolds www.vrr.ulaval.ca/bd/chercheur/fi che/283780.html Ziltener, Hermann Johann Biomedical Research Centre U. British BC Tissue engineering— Various No www.brc.ubc.ca/drupal5/node/38 [email protected] Columbia scaffolds Zúñiga-Pfl ücker, Juan-Carlos Sunnybrook Research Institute U. Toronto ON Stem cells—embryonic Immunological— CRC in www.sunnybrook.ca/research/team/member. [email protected] immunodefi ciency Developmental asp?t=13&m=191&page=1100 Immunology

94 appendiX 3A. RESEARCHERS IN ALPHABETICAL ORDER 3

universitY/ tYpe of regen. endoWed researCHer researCH institution institution provinCe Med disease CHair url eMail Woodhouse, Kimberly Queen’s U. ON Tissue engineering— Cardiovascular No chemeng.queensu.ca/people/faculty/woodhouse/ [email protected] scaffolds, stem cells index.php Wouters, Bradley Ontario Cancer Institute, University U. Toronto ON Stem cells—cancer Cancer No www.uhnres.utoronto.ca/researchers/profi le. [email protected] Health Network php?lookup=27665 Wrana, Jeffrey Samuel Lunenfeld Research Institute, U. Toronto ON Technology—stem Cancer CRC in Systems www.lunenfeld.ca/researchers/Wrana [email protected] Mount Sinai Hospital cells—high throughput Biology; Mary analysis Janigan Research Chair in Molecular Cancer Therapeutics Wynder, Christopher McMaster U. ON Stem cells—embryonic Cancer CRC in Epigenetic fhs.mcmaster.ca/main/canada_chairs/epigenetic_ [email protected] Control of Stem control_of_stem_cells_chair.html Cells Yahia, L’Hocine École QC Biomaterials Musculoskeletal No www.polymtl.ca/recherche/rc/en/professeurs/ [email protected] polytechnique de details.php?NoProf=243 Montreal Yang, Xiang-Jiao McGill U. QC Stem cells—various— Aging No www.mcgill.ca/mog/research/yang/ [email protected] unspecifi ed Yip, Christopher The Donnelly Centre U. Toronto ON Stem cells— Various No biochemistry.utoronto.ca/yip/bch.html [email protected] hematopoietic Yong, Von Wee Associated with Hotchkiss Brain U. Calgary AB Stem cells— Neurological—multiple No www.hbi.ucalgary.ca/members/yong [email protected] Institute hematopoietic sclerosis Zackenhaus, Eldad U. Toronto ON Stem cells—cancer Cancer No medbio.utoronto.ca/faculty/zacksenhaus.html [email protected]

95 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3b. Researchers According to Regenerative Medicine Focus researCH universitY/ researCHer institution institution provinCe regen. Med desCription tissue engineering inCluding BioMaterials Acker, Jason U. Alberta AB Tissue engineering—cell storage

Amsden, Brian Queens U. ON Tissue engineering—scaffolds

Antoniou, John Jewish General McGill U. QC Tissue engineering—scaffold; Stem cells— Hospital mesenchymal Auger, François A. LOEX U. Laval QC Tissue engineering—cell culture

Barralet, Jake McGill U. QC Biomaterials

Barrett, Christopher McGill U. QC Biomaterials

Berthod, François LOEX U. Laval QC Tissue engineering—stem cells

Brash, John McMaster U. ON Biomaterials Brunette, Donald Biomedical Research U. British BC Tissue engineering—biomaterials, stem Centre Columbia cells—mesenchymal

Burt, Helen Mary Biomedical Research U. British BC Tissue engineering—biomaterials, stem Centre Columbia cells—mesenchymal

Buschmann, Michael École QC Biomaterials polytechnique de Montréal Cao, Xudong U. Ottawa ON Biomaterials; Tissue engineering—stem cells Catelas, Isabelle U. Ottawa ON Tissue engineering

Chang, Thomas Ming Swi Artifi cial Cells and McGill U. QC Tissue engineering—artifi cial blood cells Organs Research Centre Chen, Daniel (Xiongbiao) U. Saskatchewan Sask Tissue engineering—scaffolds

Davies, John U. Toronto ON Tissue engineering—scaffolds; Stem cells—mesnchymal

De Crescenzo, Gregory École QC Biomaterials polytechnique de Montréal Doillon, Charles U. Laval QC Tissue engineering—biomaterials

El-Hakim, Assaad McGill U. QC Tissue engineering—biomaterials, cells

Farhat, Walid Hospital for Sick U. Toronto ON Tissue engineering —cells, scaffold Children

96 appendiX 3B. RESEARCHERS ACCORDING TO REGENERATIVE MEDICINE FOCUS 3

researCH universitY/ researCHer institution institution provinCe regen. Med desCription Faucheux, Nathalie U. Sherbrooke QC Biomaterials—scaffolds

Favis, Basil École QC Biomaterials—scaffolds polytechnique de Montréal Fernlund, Goran U. British BC Tissue engineering—biomaterials, stem Columbia cells—mesenchymal

Filiaggi, Mark J. Dalhousie U. NS Biomaterials

Ghanem, Amyl Dalhousie U. NS Biomaterials—tissue engineering

Giasson, Claude J. LOEX affi liation U. Montréal QC Tissue engineering

Goulet, Francine LOEX U. Laval QC Tissue engineering—biomaterials, culture

Griffi th, May Sprott Centre for Stem U. Ottawa ON Biomaterials—scaffolds; Tissue Cell Research, Ottawa engineering—stem cells Health Research Institute Hamilton, Douglas U. Western ON Biomaterials; Tissue engineering Ontario Harvey, Edward McGill U. QC Biomaterials; Tissue engineering—cells

Hoare, Todd McMaster U. ON Biomaterials Hoemann, Caroline École QC Tissue engineering—cells; Biomaterials polytechnique de Montréal Hunter, Christopher U. Calgary AB Tissue engineering—stem cells; Biomaterials Johnston, James U. Saskatchewan Sask Tissue engineering—scaffolds

Jones, Elizabeth McGill U. QC Tissue engineering

Jones, Kim McMaster U. ON Biomaterials Kamacheva, Eugenia U. Toronto ON Biomaterials

Kandel, Rita Samuel Lunenfeld U. Toronto ON Tissue engineering—biomaterials, stem Research Institute, cells Mount Sinai Hospital Keeley, Fred Hospital for Sick U. Toronto ON Biomaterials Children Ko, Frank U. British BC Tissue engineering—scaffolds Columbia Korbutt, Gregory Alberta Diabetes U. Alberta AB Tissue engineering—stem cells, islet; Institute Transplantation

97 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3b. Cont’d researCH universitY/ researCHer institution institution provinCe regen. Med desCription Kreplak, Laurent Dalhousie U. NS Biomaterials—scaffolds Lacroix, Dan LOEX U. Laval QC Tissue engineering Langelier, Eve U. Sherbrooke QC Tissue engineering; Biomaterials Legge, Raymond U. Waterloo ON Tissue engineering—scaffolds McGuigan, Alison Institute of U. Toronto ON Tissue engineering—cells Biomaterials and Biomedical Engineering Mequanint, Kibret U. Western ON Tissue engineering—scaffolds Ontario Moulin, Véronique LOEX U. Laval QC Tissue engineering—stem cells Nanci, Antonio U. Montréal QC Tissue engineering—cells; Biomaterials Nazhat, Showan McGill U. QC Biomaterials—scaffolds; Tissue engineering Pilliar, Robert U. Toronto ON Biomaterials; Tissue engineering Pouliot, Roxane LOEX U. Laval QC Tissue engineering; Biomaterials Prakash, Satya McGill U. QC Biomaterials; Tissue engineering

Quinn, Thomas McGill U. QC Tissue engineering

Radisic, Milica U. Toronto ON Tissue engineering—scaffolds, cells; Stem cells—angiogenic progenitor Ramsay, Bruce Queens U. ON Tissue engineering—scaffolds

Reinhardt, Dieter McGill U. QC Tissue engineering—biomaterials, cells

Santerre, Paul U. Toronto ON Tissue engineering—biomaterials, cells

Sefton, Michael The Donnelly Centre U. Toronto ON Tissue engineering—biomaterials, cells

Sheardown, Heather McMaster U. ON Biomaterials Shoichet, Molly McEwen Centre U. Toronto ON Tissue engineering: biomaterials— for Regenerative scaffolds; Stem cells Medicine, Toronto General Research Institute, University Health Network Sun, Yu U. Toronto ON Tissue engineering—screening Tabrizian, Maryam McGill U. QC Biomaterials; Tissue engineering—scaffolds Toyserkani, Ehsan U. Waterloo ON Biomaterials—scaffolds Tufenkji, Nathalie McGill U. QC Biomaterials—scaffolds Unsworth, Larry U. Alberta AB Biomaterials—scaffolds Veres, Teodor U. Laval QC Biomaterials; Tissue engineering—cells Vermette, Patrick U. Sherbrooke QC Tissue engineering—cell culture; Biomaterials—scaffolds

98 appendiX 3B. RESEARCHERS ACCORDING TO REGENERATIVE MEDICINE FOCUS 3

researCH universitY/ researCHer institution institution provinCe regen. Med desCription Waldman, Stephen Queens U. ON Tissue engineering—cell culture Walker, Gilbert Creighton U. Toronto ON Biomaterials Walus, Konrad U. British BC Biomaterials—scaffolds Columbia Weisel, Richard Toronto General U. Toronto ON Tissue engineering: Stem cells— Research Institute, transplantation University Health Network Wells, Sarah Dalhousie U. NS Tissue engineering—scaffolds Wertheimer, Michel Robert École QC Biomaterials polytechnique de Montréal Whyne, Cari Sunnybrook Research U. Toronto ON Tissue engineering Institute Woodhouse, Kimberly Queen’s U. ON Tissue engineering—scaffolds, stem cells Yahia, L’Hocine École QC Biomaterials polytechnique de Montréal Zhang, Ze U. Laval QC Tissue engineering—scaffolds Ziltener, Hermann Johann Biomedical Research U. British BC Tissue engineering—scaffolds Centre Columbia BioproCessing Behie, Leo Includes: U. Calgary AB Bioprocessing—stem cells production/ Pharmaceutical culture Production Research Facility Garnier, Alain U. Laval QC Bioprocessing—stem cells—culture Jervis, Eric U. Waterloo ON Bioprocessing—cell culture; Tissue engineering Jolicoeur, Mario École QC Bioprocessing polytechnique de Montréal Kallos, Michael Includes: U. Calgary AB Bioprocessing—stem cells, tissue culture Pharmaceutical Production Research Facility Sen, Arindom U. Calgary AB Bioprocessing—stem cells—adult steM Cell Handling teCHnologies (e.g., HigH tHrougHput sorting, CrYopreservation) Elliott, Janet Anne Wade U. Alberta AB Technology—stem cells— cryopreservation

Figeys, Daniel U. Ottawa ON Technology—stem cells—cell handling McGann, Locksley Earl U. Alberta AB Technology—stem cells— cryopreservation Park, Edward U. Victoria BC Technology—stem cells—cell sorting

99 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3b. Cont’d researCH universitY/ researCHer institution institution provinCe regen. Med desCription Piret, James Michael Smith U. British BC Technology—stem cells, incl. Laboratories Columbia hematopoietic—high throughput analysis; Bioprocessing—cell culture Simmons, Craig U. Toronto ON Technology—high throughput screening; Stem cells—mesenchymal, cord blood; Tissue engineering Tanner, Scott U. Toronto ON Technology—stem cells—cancer; High throughput technology Turner, Robin Michael Smith U. British BC Technology—stem cells—embryonic; Laboratories Columbia Analysis, production Wrana, Jeffrey Samuel Lunenfeld U. Toronto ON Technology—stem cells—high throughput Research Institute, analysis Mount Sinai Hospital regeneration unspeCified Akimenko, Marie-Andrée Ottawa Hospital U. Ottawa ON Regeneration—unspecifi ed—tissue Research Institute Downey, Gregory U. Toronto ON Regenerative medicine—unspecifi ed von Harsdorf, Rudiger McEwen Centre U. Toronto ON Regeneration—unspecifi ed—heart for Regenerative Medicine, Toronto General Research Institute, University Health Network soCial sCienCes & HuManities Baylis, Françoise Dalhousie U. NS Social science & humanities Bubela, Tania U. Alberta AB Social science & humanities Caulfi eld, Tim U. Alberta AB Social science & humanities Chandler, Jennifer U. Ottawa ON Social science & humanities Daar, Abdallah McLaughlin-Rotman U. Toronto ON Social science & humanities Centre for Global Health, University Health Network Einsiedel, Edna U. Calgary AB Social science & humanities Glass, Kathleen McGill U. QC Social science & humanities Illes, Judy U. British BC Social science & humanities Columbia Ingram, Liz U. Alberta AB Social science & humanities Knoppers, Bartha McGill U. QC Social science & humanities Leibing, Annette U. Montréal QC Social science & humanities Lemmens, Trudo U. Toronto ON Social science & humanities Leroux, Therese U. Montréal QC Social science & humanities McDonald, Michael U. British BC Social science & humanities Columbia Menon, Devidas U. Alberta AB Social science & humanities

100 appendiX 3B. RESEARCHERS ACCORDING TO REGENERATIVE MEDICINE FOCUS 3

researCH universitY/ researCHer institution institution provinCe regen. Med desCription von Tigerstrom, Barbara U. Saskatchewan Sask Social science & humanities steM Cells—pluripotent eMBrYoniC Bader, Gary Institute of U. Toronto ON Stem cells—embryonic Biomaterials and Biomedical Engineering Doble, Bradley Stem Cell and Cancer McMaster U. ON Stem cells—embryonic Research Institute Draper, Jonathan Stem Cell and Cancer McMaster U. ON Stem cells—embryonic Research Institute

Dufort, Daniel McGill U. QC Stem cells—embryonic Dumont, Dan Sunnybrook Research U. Toronto ON Stem cells—embryonic Institute Emili, Andrew The Donnelly Centre— U. Toronto ON Stem cells—embryonic Banting and Best Department of Medical Research Gregory-Evan, Kevin Vancouver Coastal U. British BC Stem cells—embryonic Health Research Columbia Institute Gutkowska, Jolanta Centre de recherche U. Montréal QC Stem cells—embryonic du Centre hospitalier de l’Université de Montréal Helgason, Cheryl BC Cancer Agency U. British BC Stem cells—embryonic Columbia Hicks, Geoffrey Cancer Care U. Manitoba MB Stem cells—embryonic Manitoba—Institute of Cell Biology Hoodless, Pamela Terry Fox Laboratory, U. British BC Stem cells—embryonic BC Cancer Agency Columbia Huang, Sui U. Calgary AB Stem cells—embryonic Hughes, Timothy The Donnelly Centre— U. Toronto ON Stem cells—embryonic Banting and Best Department of Medical Research

Husain, Mansoor McEwen Centre U. Toronto ON Stem cells—embryonic for Regenerative Medicine, Toronto General Research Institute, University Health Network Julius, Michael Sunnybrook Research U. Toronto ON Stem cells—embryonic Institute Kaern, Mads U. Ottawa ON Stem cells—embryonic

101 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3b. Cont’d researCH universitY/ researCHer institution institution provinCe regen. Med desCription Keller, Gordon McEwen Centre for U. Toronto ON Stem cells—embryonic Regenerative Medicine and Ontario Cancer Institute, University Health Network Kelly, Kevin Francis Stem Cell and Cancer McMaster U. ON Stem cells—embryonic Research Institute Kothary, Rashmi K. Ottawa Hospital U. Ottawa ON Stem cells—embryonic Research Institute Lajoie, Gilles U. Western ON Stem cells—embryonic Ontario Lefebvre, Louis U. British BC Stem cells—embryonic Columbia Lynn, Francis U. British BC Stem cells—embryonic Columbia Marra, Marco BC Cancer Agency, U. British BC Stem cells—embryonic Genome Sciences Columbia Centre Matyas, John Robert U. Calgary AB Stem cells—embryonic

McBurney, Michael Ottawa Hospital U. Ottawa ON Stem cells—embryonic Research Institute Michalak, Marek S. U. Alberta AB Stem cells—embryonic Morris, Quaid The Donnelly Centre, U. Toronto ON Stem cells—embryonic Banting and Best Department of Medical Research Opas, Michal J. U. Toronto ON Stem cells—embryonic Pang, Stephen Queen’s U. ON Stem cells—embryonic Pilon, Nicolas U. Québec à QC Stem cells—embryonic Montréal Post, Martin Hospital for Sick U. Toronto ON Stem cells—embryonic Children Puri, Mira Sunnybrook Research U. Toronto ON Stem cells—embryonic Institute Rossant, Janet Hospital for Sick U. Toronto ON Stem cells—embryonic Children Santamaria, Pere U. Calgary AB Stem cells—embryonic Schuh, Andre Ontario Cancer U. Toronto ON Stem cells—embryonic Institute, University Health Network Skerjanc, Ilona Sylvia U. Ottawa ON Stem cells—embryonic Smith, Lawrence C. U. Montréal QC Stem cells—embryonic Stifani, Stefano Montreal Neurological McGill U. QC Stem cells—embryonic Institute

Wang, Lisheng U. Ottawa ON Stem cells—embryonic

102 appendiX 3B. RESEARCHERS ACCORDING TO REGENERATIVE MEDICINE FOCUS 3

researCH universitY/ researCHer institution institution provinCe regen. Med desCription Wynder, Christopher McMaster U. ON Stem cells—embryonic Zúñiga-Pfl ücker, Juan-Carlos Sunnybrook Research U. Toronto ON Stem cells—embryonic Institute induCed pluripotent Betts, Dean U. Western ON Stem cells—pluripotent—induced Ontario pluripotent Moffat, Jason The Donnelly Centre U. Toronto ON Stem cells—pluripotent—induced pluripotent induCed pluripotent and eMBrYoniC Ellis, James Hospital for Sick U. Toronto ON Stem cells—pluripotent—embryonic, Children induced pluripotent Grant, Denis U. Toronto ON Stem cells—pluripotent—embryonic, induced pluripotent Rafuse, Victor Dalhousie U. NS Stem cells—pluripotent—embryonic, induced pluripotent; neural Rancourt, Derrick U. Calgary AB Stem cells—pluripotent—embryonic, induced pluripotent Rastegar, Mojgan U. Manitoba MB Stem cells—pluripotent—induced pluripotent, embryonic Tyndale, Rachel U. Toronto ON Stem cells—pluripotent—embryonic, induced pluripotent steM Cells—tissue speCifiC steM Cells—adult unspeCified Antel, Jack McGill U. QC Stem cells—adult unspecifi ed Bani, Mahmud Associated with U. Ottawa ON Stem cells—adult unspecifi ed National Research Council of Canada, Institute for Biological Sciences Brodt, Pnina The Research Institute McGill U. QC Stem cells—adult—stromal of the McGill University Health Centre

Carrier, Patrick LOEX U. Laval QC Stem cells—adult—epithelial (from cornea) Courtman, David Sprott Centre for Stem U. Ottawa ON Stem cells—adult—endothelial progenitor Cell Research, Ottawa Hospital Research Institute Germain, Lucie LOEX U. Laval QC Stem cells—adult—epithelial Hassell, John McMaster U. ON Stem cells—adult, cancer Hill, David Lawson Health U. Western ON Stem cells—adult unspecifi ed Research Institute, Ontario London Health Sciences Centre Horb, Markoe Institut de recherches U. Montréal QC Stem cells—adult—endodermal cliniques de Montréal progenitors

103 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3b. Cont’d researCH universitY/ researCHer institution institution provinCe regen. Med desCription Jirik, Frank Southern Alberta U. Calgary AB Stem cells—adult unspecifi ed Cancer Research Institute Metz, Luanne Associated with U. Calgary AB Stem cells—adult—endogenous progenitor Hotchkiss Brain Institute Prato, Frank Lawson Health U. Western ON Stem cells—adult—endothelial progenitor Research Institute, Ontario London Health Sciences Centre Stewart, Duncan Sprott Centre for Stem U. Ottawa ON Stem cells—adult unspecifi ed Cell Research, Ottawa Health Research Institute Tator, Charles Toronto General U. Toronto ON Stem cells—adult unspecifi ed Research Institute, University Health Network Tsilfi dis, Catherine Sprott Centre for Stem U. Ottawa ON Stem cells—adult unspecifi ed Cell Research, Ottawa Health Research Institute Verchere, Bruce U. British BC Stem cells—adult unspecifi ed Columbia Woodgett, James Samuel Lunenfeld U. Toronto ON Stem cells—adult unspecifi ed Research Institute, Mount Sinai Hospital steM Cells—aMniotiC Puymirat, Jack U. Laval QC Stem cells—amniotic steM Cells—Bone MarroW Hess, David John P. Robarts U. Western ON Stem cells—bone marrow (mesenchymal, Research Institute Ontario hematopoietic) Jackson, Michael U. Manitoba MB Stem cells—bone marrow Keating, Armand U. Toronto ON Stem cells—bone marrow—mesenchymal, hematopoietic Krieger, Charles Simon Fraser U. BC Stem cells—bone marrow Lewis, James Franklin Lawson Health U. Western ON Stem cells—bone marrow Research Institute, Ontario London Health Sciences Centre Putnins, Edward U. British BC Stem cells—bone marrow Columbia Qayumi, Karim Vancouver Coastal U. British BC Stem cells—bone marrow Health Research Columbia Institute Rivest, Serge Centre hospitalier de U. Laval QC Stem cells—bone marrow l’Université Laval

104 appendiX 3B. RESEARCHERS ACCORDING TO REGENERATIVE MEDICINE FOCUS 3

researCH universitY/ researCHer institution institution provinCe regen. Med desCription Toze, Cynthia BC Cancer Agency U. British BC Stem cells—bone marrow Columbia Tran, Simon McGill U. QC Stem cells—bone marrow Tredget, Edward Eric U. Alberta AB Stem cells—bone marrow Tremblay, Jacques Centre hospitalier de U. Laval QC Stem cells—bone marrow l’Université Laval

Trigatti, Bernardo Louis McMaster U. ON Stem cells—bone marrow steM Cells—CanCer Allan, Alison London Regional U. Western ON Stem cells—cancer Cancer Program, Ontario London Health Sciences Centre Bramson, Jonathan McMaster U. ON Stem cells—cancer Brinkman, Ryan Terry Fox Laboratory, U. British BC Stem cells—cancer BC Cancer Agency Columbia Dankort, David McGill U. QC Stem cells—cancer

DeCoteau, John U. Saskatchewan Sask Stem cells—cancer Geyer, Ronald U. Saskatchewan Sask Stem cells—cancer Ghanekar, Anand U. Toronto ON Stem cells—cancer Giacomantonio, Carman A. Dalhousie U. NS Stem cells—cancer Hedley, David William Ontario Cancer U. Toronto ON Stem cells—cancer Institute, University Health Network Hill, Richard Ontario Cancer U. Toronto ON Stem cells—cancer Institute, University Health Network Hombach-Klonisch, Sabine U. Manitoba MB Stem cells—cancer Kamnasaran, Deepak U. Laval QC Stem cells—cancer Kaplan, David Hospital for Sick U. Toronto ON Stem cells—cancer Children Klonisch, Thomas CancerCare Manitoba U. Manitoba MB Stem cells—cancer Lee, Patrick W.K. Dalhousie U. NS Stem cells—cancer Neel, Benjamin Ontario Cancer U. Toronto ON Stem cells—cancer Institute, University Health Network O’Brien, Catherine Adell Ontario Cancer U. Toronto ON Stem cells—cancer Institute, University Health Network Pilarski, Linda U. Alberta AB Stem cells—cancer Rak, Janusz The Research Institute McGill U. QC Stem cells—cancer of the McGill University Health Centre

105 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3b. Cont’d researCH universitY/ researCHer institution institution provinCe regen. Med desCription Raouf, Afshin Cancer Care U. Manitoba MB Stem cells—cancer Manitoba—Institute of Cell Biology Reilly, Raymond Matthew U. Toronto ON Stem cells—cancer Roy, Denis-Claude Centre de recherche U. Montréal QC Stem cells—cancer de l’Hôpital Maisonneuve- Rosemont Schimmer, Aaron Ontario Cancer U. Toronto ON Stem cells—cancer Institute, University Health Network Singh, Sheila Stem Cell and Cancer McMaster U. ON Stem cells—cancer Research Institute

Tabori, Uri Hospital for Sick U. Toronto ON Stem cells—cancer Children Tang, Damu St. Joseph’s Hospital McMaster U. ON Stem cells—cancer (Hamilton)

Tannock, Ian Frederick Ontario Cancer U. Toronto ON Stem cells—cancer Institute, University Health Network Wong, Peggy Hospital for Sick U. Toronto ON Stem cells—cancer Children Wouters, Bradley Ontario Cancer U. Toronto ON Stem cells—cancer Institute, University Health Network Zackenhaus, Eldad U. Toronto ON Stem cells—cancer steM Cells—CardiaC Megeney, Lynn Sprott Centre for Stem U. Ottawa ON Stem cells—cardiac Cell Research, Ottawa Health Research Institute Pasumarthi, Kishore Babu S. Dalhousie U. NS Stem cells—cardiac progenitor Stewart, Alexandre University of Ottawa U. Ottawa ON Stem cells—cardiac Heart Institute steM Cells—Cord Blood Chen, Jie U. Alberta AB Stem cells—cord blood Couban, Stephen Dalhousie U. NS Stem cells—cord blood Duval, Michel U. Montréal QC Stem cells—cord blood Underhill, Michael U. British BC Stem cells—cord blood Columbia steM Cells—derMal Biernaskie, Jeffrey A. Associated with U. Calgary AB Stem cells—dermal Hotchkiss Brain Institute

106 appendiX 3B. RESEARCHERS ACCORDING TO REGENERATIVE MEDICINE FOCUS 3

researCH universitY/ researCHer institution institution provinCe regen. Med desCription Li, Julang U. Guelph ON Stem cells—dermal Midha, Rajiv Associated with U. Calgary AB Stem cells—dermal Hotchkiss Brain Institute steM Cells—fat Arora, Rakesh C. Associated with U. Manitoba MB Stem cells—fat National Research Council of Canada, Institute for Biological Sciences Flynn, Lauren Queen’s U. ON Stem cells—fat; Tissue engineering— scaffolds Fradette, Julie LOEX U. Laval QC Stem cells—fat; Tissue engineering Tian, Ganghong (Hong) Associated with U. Manitoba MB Stem cells—fat National Research Council of Canada, Institute for Biological Sciences steM Cells—fetal Drouin, Jacques Institut de recherches U. Montréal QC Stem cells—fetal cliniques de Montréal Mendez, Ivar Dalhousie U. NS Stem cells—fetal steM Cells—gastrointestinal Bjerknes, Matthew J. U. Toronto ON Stem cells—gastrointestinal Kieffer, Tim U. British BC Stem cells—gastrointestinal Columbia steM Cells—gerMline Dobrinski, Ina U. Calgary AB Stem cells—germline—testis Nagano, Makoto The Research Institute McGill U. QC Stem cells—germline—sperm of the McGill University Health Centre Robaire, Bernard McGill U. QC Stem cells—germline steM Cells—HeMatopoietiC Allan, David Sprott Centre for Stem U. Ottawa ON Stem cells—hematopoietic Cell Research, Ottawa Health Research Institute Anderson, Michele Sunnybrook Research U. Toronto ON Stem cells—hematopoietic Institute Atkins, Harry Sprott Centre for Stem U. Ottawa ON Stem cells—hematopoietic Cell Research, Ottawa Health Research Institute

107 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3b. Cont’d researCH universitY/ researCHer institution institution provinCe regen. Med desCription Audet, Julie Institute of U. Toronto ON Stem cells—hematopoietic Biomaterials and Biomedical Engineering Barabé, Frédéric U. Laval QC Stem cells—hematopoietic Barber, Dwayne Ontario Cancer U. Toronto ON Stem cells—hematopoietic Institute, University Health Network Beausejour, Christian Hôpital Sainte-Justine U. Montréal QC Stem cells—hematopoietic (Montréal) Ben-David, Yaacov Sunnybrook Research U. Toronto ON Stem cells—hematopoietic Institute Bijl, Janetta U. Montréal QC Stem cells—hematopoietic Brand, Marjorie Sprott Centre for Stem U. Ottawa ON Stem cells—hematopoietic Cell Research, Ottawa Health Research Institute Carreau, Madeleine Centre hospitalier de U. Laval QC Stem cells—hematopoietic l’Université Laval Casper, Robert Samuel Lunenfeld U. Toronto ON Stem cells—hematopoietic Research Institute, Mount Sinai Hospital Crump, Michael A. Ontario Cancer U. Toronto ON Stem cells—hematopoietic Institute, University Health Network Denburg, Judah Aryeh McMaster U. ON Stem cells—hematopoietic Doyle, John U. Toronto ON Stem cells—hematopoietic Eaves, Allen Terry Fox Laboratory, U. British BC Stem cells—hematopoietic BC Cancer Agency Columbia Ellis, Anne Queen’s U. ON Stem cells—hematopoietic (cord blood) Gassas, Adam Hospital for Sick U. Toronto ON Stem cells—hematopoietic Children Guidos, Cynthia Hospital for Sick U. Toronto ON Stem cells—hematopoietic Children Heveker, Nikolaus Hôpital Sainte-Justine U. Montréal QC Stem cells—hematopoietic Hoang, Trang Institute for Research U. Montréal QC Stem cells—hematopoietic in Immunology and Cancer Hogge, Donna Terry Fox Laboratory, U. British BC Stem cells—hematopoietic BC Cancer Agency Columbia Hope, Kristin Jill Stem Cell and Cancer McMaster U. ON Stem cells—hematopoietic Research Institute Humphries, Keith Terry Fox Laboratory, U. British BC Stem cells—hematopoietic BC Cancer Agency Columbia

108 appendiX 3B. RESEARCHERS ACCORDING TO REGENERATIVE MEDICINE FOCUS 3

researCH universitY/ researCHer institution institution provinCe regen. Med desCription Iscove, Norman McEwen Centre U. Toronto ON Stem cells—hematopoietic for Regenerative Medicine, and Ontario Cancer Institute, University Health Network Jiang, Xiaoyan Terry Fox Laboratory, U. British BC Stem cells—hematopoietic BC Cancer Agency Columbia Joshi, Sadhna U. Toronto ON Stem cells—hematopoietic Karsan, Aly BC Cancer Agency U. British BC Stem cells—hematopoietic Columbia Krystal, Gerald Terry Fox Laboratory, U. British BC Stem cells—hematopoietic BC Cancer Agency Columbia Lessard, Julie Institute for Research U. Montréal QC Stem cells—hematopoietic in Immunology and Cancer Levesque, Eric Centre hospitalier de U. Laval QC Stem cells—hematopoietic l’Université Laval Li, Ren-Ke McEwen Centre U. Toronto ON Stem cells—hematopoietic for Regenerative Medicine, Toronto General Research Institute, University Health Network McNagny, Kelly Biomedical Research U. British BC Stem cells—hematopoietic Centre Columbia Minden, Mark David Ontario Cancer U. Toronto ON Stem cells—hematopoietic Institute, University Health Network Mollica, Luigina Centre de recherche U. Montréal QC Stem cells—hematopoietic de l’Hôpital Maisonneuve- Rosemont Moroy, Tarik Institut de recherches U. Montréal QC Stem cells—hematopoietic cliniques de Montréal Munoz Risueno, Ruth Stem Cell and Cancer McMaster U. ON Stem cells—hematopoietic Research Institute Nevill, Thomas Vancouver Coastal U. British BC Stem cells—hematopoietic Health Research Columbia Institute Podor, Thomas iCapture U. British BC Stem cells—hematopoietic (bone marrow) Columbia Robert, François Institut de recherches U. Montréal QC Stem cells—hematopoietic cliniques de Montréal Rossi, Fabio Biomedical Research U. British BC Stem cells—hematopoietic Centre Columbia Rottapel, Robert Ontario Cancer U. Toronto ON Stem cells—hematopoietic Institute, University Health Network

109 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3b. Cont’d researCH universitY/ researCHer institution institution provinCe regen. Med desCription Roy, Jean Centre de recherche U. Montréal QC Stem cells—hematopoietic de l’Hôpital Maisonneuve- Rosemont Schrader, John W. Biomedical Research U. British BC Stem cells—hematopoietic Centre Columbia Schultz, Kirk Child & Family U. British BC Stem cells—hematopoietic Research Institute Columbia Smith, Clayton Terry Fox Laboratoy, U. British BC Stem cells—hematopoietic BC Cancer Agency Columbia Song, Kevin Vancouver Coastal U. British BC Stem cells—hematopoietic Health Research Columbia Institute Till, Jim Ontario Cancer U. Toronto ON Stem cells—hematopoietic Institute, University Health Network Tremblay, Michel L. McGill U. QC Stem cells—hematopoietic Wall, Donna Cancer Care Manitoba U. Manitoba MB Stem cells—hematopoietic Wang, Chen U. Toronto ON Stem cells—hematopoietic Wells, Richard Alexander Sunnybrook Research U. Toronto ON Stem cells—hematopoietic Institute Yip, Christopher The Donnelly Centre U. Toronto ON Stem cells—hematopoietic Yong, Von Wee Associated with U. Calgary AB Stem cells—hematopoietic Hotchkiss Brain Institute steM Cells—lung Thebaud, Bernard U. Alberta AB Stem cells—lung steM Cells—MaMMarY Dedhar, Shoukat BC Cancer Agency U. British BC Stem cells—mammary Columbia Egan, Sean Hospital for Sick U. Toronto ON Stem cells—mammary epithelial Children steM Cells—MesenCHYMal Alman, Benjamin Hospital for Sick U. Toronto ON Stem cells—mesenchymal Children Aubin, Jane U. Toronto ON Stem cells—mesenchymal Dick, Alexander Sunnybrook Research U. Toronto ON Stem cells—mesenchymal Institute Eliopoulos, Nicoletta McGill U. QC Stem cells—mesenchymal Ferguson, Peter Charles Mount Sinai Hospital U. Toronto ON Stem cells—mesenchymal stromal Frei, Hanspeter Carleton U. ON Stem cells—mesenchymal Hebert, Marie-Josee Centre de recherche U. Montréal QC Stem cells—mesenchymal du Centre hospitalier de l’Université de Montréal

110 appendiX 3B. RESEARCHERS ACCORDING TO REGENERATIVE MEDICINE FOCUS 3

researCH universitY/ researCHer institution institution provinCe regen. Med desCription Ly, Hung Montreal Heart U. Montréal QC Stem cells—mesenchymal Institute Mak, Tak Ontario Cancer U. Toronto ON Stem cells—mesenchymal Institute, University Health Network McElwee, Kevin Vancouver Coastal U. British BC Stem cells—mesenchymal Health Research Columbia Institute Mwale, Fackson Jewish General McGill U. QC Stem cells—mesenchymal Hospital, Lady Davis Institute Ohashi, Pamela Sumiko Ontario Cancer U. Toronto ON Stem cells—mesenchymal Institute, University Health Network Pelletier, Marc New Brunswick Heart New Brunswick NB Stem cells—mesenchymal Centre Heart Centre Shaw, Patricia Ann Ontario Cancer U. Toronto ON Stem cells—mesenchymal Institute, University Health Network Suuronen, Erik University of Ottawa U. Ottawa ON Stem cells—mesenchymal and endothelial Heart Institute progenitor; Biomaterials—scaffolds Waddell, Thomas McEwen Centre U. Toronto ON Stem cells—mesenchymal for Regenerative Medicine, Toronto General Research Institute, University Health Network Ward, Christopher Andrew Queen’s U. ON Stem cells—mesenchymal Wiper-Bergeron, Nadine Louise U. Ottawa ON Stem cells—mesenchymal steM Cells—MusCle Dilworth, Jeffrey Sprott Centre for Stem U. Ottawa ON Stem cells—muscle progenitors Cell Research, Ottawa Health Research Institute Grenier, Guillaume U. Sherbrooke QC Stem cells—muscle progenitors Hawke, Thomas McMaster U. ON Stem cells—muscle progenitor Merrifi eld, Peter U. Western ON Stem cells—muscle Ontario Parise, Gianni McMaster U. ON Stem cells—muscle Savard, Pierre U. Laval QC Stem cells—muscle Vincent, Michel U. Laval QC Stem cells—muscle progenitor steM Cells—neural Aviv, Tzvi Hospital for Sick U. Toronto ON Stem cells—neural Children Bennett, Steffany U. Ottawa ON Stem cells—neural Calderone, Angelo Montreal Heart U. Montréal QC Stem cells—neural Institute

111 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3b. Cont’d researCH universitY/ researCHer institution institution provinCe regen. Med desCription Cayouette, Michel Institut de recherches U. Montréal QC Stem cells—neural cliniques de Montréal

Cregan, Sean John P. Robarts U. Western ON Stem cells—neural Research Institute Ontario Dirks, Peter Hospital for Sick U. Toronto ON Stem cells—neural Children Fehlings, Michael McEwen Centre for U. Toronto ON Stem cells—neural Regenerative Medicine and McLaughlin Center for Molecular Medicine, Toronto Western Research Institute, University Health Network Fernandes, Karl U. Montréal QC Stem cells—neural Hazell, Alan Stewart Centre de recherche U. Montréal QC Stem cells—neural du Centre hospitalier de l’Université de Montréal

Huang, Annie Hospital for Sick U. Toronto ON Stem cells—neural Children Karimi-Abdolrezaee, Soheila U. Manitoba MB Stem cells—neural Kim, Seung Vancouver Coastal U. British BC Stem cells—neural Health Research Columbia Institute Laposa, Rebecca U. Toronto ON Stem cells—neural Lecanu, Laurent The Research Institute McGill U. QC Stem cells—neural of the McGill University Health Centre Levin, Leonard Centre de recherche U. Montréal QC Stem cells—neural de l’Hôpital Maisonneuve- Rosemont Morshead, Cindi U. Toronto ON Stem cells—neural Roskams, Jane U. British BC Stem cells—neural Columbia Tropepe, Vince U. Toronto ON Stem cells—neural van der Kooy, Derek McEwen Centre U. Toronto ON Stem cells—neural (incl. retinal) for Regenerative Medicine, Toronto General Research Institute, University Health Network Vanderluit, Jacqueline Memorial U. NL Stem cells—neural

112 appendiX 3B. RESEARCHERS ACCORDING TO REGENERATIVE MEDICINE FOCUS 3

researCH universitY/ researCHer institution institution provinCe regen. Med desCription Weiss, Samuel Associated with U. Calgary AB Stem cells—neural Hotchkiss Brain Institute steM Cells—ovarian epitHelial Farookhi, Riaz McGill U. QC Stem cells—ovarian epithelial steM Cells—panCreatiC Anderson, Colin C. U. Alberta AB Stem cells—pancreatic (islet) Johnson, James U. British BC Stem cells—pancreatic (islet) Columbia Rajotte, Raymond V. U. Alberta AB Stem cells—pancreatic Rosenberg, Lawrence The Research Institute McGill U. QC Stem cells—pancreatic of the McGill University Health Centre Warnock, Garth Vancouver Coastal U. British BC Stem cells—pancreatic (islet) Health Research Columbia Institute steM Cells—retinal Chow, Bob U. Victoria BC Stem cells—retinal Wallace, Valerie Sprott Centre for Stem U. Ottawa ON Stem cells—retinal Cell Research, Ottawa Health Research Institute steM Cells—vasCular Khan, Zia U. Western ON Stem cells—vascular Ontario steM Cells—unspeCified Annabi, Borhane U. Québec à QC Stem cells—unspecifi ed Montréal Cheng, Hai-Ling Margaret Sunnybrook Research U. Toronto ON Stem cells—unspecifi ed Institute

Dekaban, Gregory John P. Robarts U. Western ON Stem cells—unspecifi ed Research Institute Ontario Dennis, James W. Samuel Lunenfeld U. Toronto ON Stem cells—unspecifi ed Research Institute, Mount Sinai Hospital Duff, Henry Joseph U. Calgary AB Stem cells—unspecifi ed Dyck, Richard Henry Associated with U. Calgary AB Stem cells—unspecifi ed Hotchkiss Brain Institute Emery, Gregory U. Montréal QC Stem cells—unspecifi ed Gramolini, Anthony Orlando The Donnelly Centre, U. Toronto ON Stem cells—unspecifi ed Banting and Best Department of Medical Research

113 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3b. Cont’d researCH universitY/ researCHer institution institution provinCe regen. Med desCription Greenblatt, Jack The Donnelly Centre, U. Toronto ON Stem cells—unspecifi ed Banting and Best Department of Medical Research Hansen, David U. Calgary AB Stem cells—unspecifi ed Kislinger, Thomas Ontario Cancer U. Toronto ON Stem cells—unspecifi ed Institute, UHN Krylov, Sergey N. York U. ON Stem cells—unspecifi ed Kuruvilla, John Ontario Cancer U. Toronto ON Stem cells—unspecifi ed Institute, University Health Network Kwon, Brian U. British BC Stem cells—unspecifi ed Columbia Labbé, Jean-Claude U. Montréal QC Stem cells—unspecifi ed Lagace, Diane U. Ottawa ON Stem cells—unspecifi ed Larouche, Danielle LOEX U. Laval QC Stem cells—unspecifi ed Leavitt, Blair Centre for Molecular U. British BC Stem cells—unspecifi ed Medicine & Columbia Therapeutics Lilicrap, David Queen’s U. ON Stem cells—unspecifi ed Meakin, Susan John P. Robarts U. Western ON Stem cells—unspecifi ed Research Institute Ontario Nemer, Mona U. Ottawa ON Stem cells—unspecifi ed Postovit, Lynne-Marie U. Western ON Stem cells—unspecifi ed Ontario Reudelhuber, Timothy Luther Institut de recherches U. Montréal QC Stem cells—unspecifi ed cliniques de Montréal Schuurmans, Carol Associated with U. Calgary AB Stem cells—unspecifi ed Hotchkiss Brain Institute Slack, Ruth Ottawa Hospital U. Ottawa ON Stem cells—unspecifi ed Research Institute Stanisz, Greg Sunnybrook Research U. Toronto ON Stem cells—unspecifi ed Institute Tanentzapf, Guy U. British BC Stem cells—unspecifi ed Columbia Tetzlaff, Wolfram U. British BC Stem cells—unspecifi ed Columbia Tsai, Eve Sprott Centre for Stem U. Ottawa ON Stem cells—unspecifi ed Cell Research, Ottawa Health Research Institute steM Cells—various Aparicio, Samuel BC Cancer Agency U. British BC Stem cells—various—hematopoietic, Columbia induced pluripotent

114 appendiX 3B. RESEARCHERS ACCORDING TO REGENERATIVE MEDICINE FOCUS 3

researCH universitY/ researCHer institution institution provinCe regen. Med desCription Bhatia, Mickie Stem Cell and Cancer McMaster U. ON Stem cells—various—pluripotent, Research Institute embryonic, hematopoietic Cross, James Charles U. Calgary AB Stem cells—various—embryonic, trophoblast, placental, germline Dick, John McEwen Centre for U. Toronto ON Stem cells—various, incl. hematopoietic Regenerative Medicine and Ontario Cancer Institute, University Health Network Eaves, Connie Terry Fox Laboratory, U. British BC Stem cells—various (embryonic, BC Cancer Agency Columbia hematopoietic, breast epithelial) Golding, Michael C. U. Western ON Stem cells—various Ontario Hough, Margaret Sunnybrook Research U. Toronto ON Stem cells—various—embryonic, Institute hematopoietic Hui, Chi-chung Hospital for Sick U. Toronto ON Stem cells—various Children Jolicoeur, Paul Institut de recherches U. Montréal QC Stem cells—various—cancer/mammary cliniques de Montréal Lansdorp, Peter Terry Fox Laboratory, U. British BC Stem cells—various—hematopoietic, BC Cancer Agency Columbia induced pluripotent, embryonic

Levy, Gary Toronto General U. Toronto ON Stem cells—various Research Institute, University Health Network Marshall, Aaron U. Manitoba MB Stem cells—various Massie, Bernard Associated with U. Montréal QC Stem cells—various—adult National Research Council— Biotechnology Research Institute McInnes, Roderick Jewish General McGill U. QC Stem cells—various—embryonic, adult Hospital, Lady Davis Institute McKerlie, Colin Samuel Lunenfeld U. Toronto ON Stem cells—various Research Institute, Mount Sinai Hospital Miller, Freda McEwen Centre U. Toronto ON Stem cells—various—dermal, neural for Regenerative Medicine, Toronto General Research Institute, University Health Network

115 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3b. Cont’d researCH universitY/ researCHer institution institution provinCe regen. Med desCription Nagy, Andras Samuel Lunenfeld U. Toronto ON Stem cells—various—pluripotent— Research Institute, induced pluripotent, embryonic; Somatic Mount Sinai Hospital and McEwen Centre for Regenerative Medicine, University Health Network Paige, Christopher Ontario Cancer U. Toronto ON Stem cells—various—embryonic, cancer Institute, University Health Network

Paquin, Joanne U. Québec à QC Stem cells—various—embryonic, adult Montréal Perkins, Theodore Sprott Center for Stem U. Ottawa ON Stem cells—various Cell Research, Ottawa Health Research Institute Rogers, Ian Samuel Lunenfeld U. Toronto ON Stem cells—various—cord blood, induced Research Institute, pluripotent, bone marrow Mount Sinai Hospital Rudnicki, Michael Sprott Centre for Stem U. Ottawa ON Stem cells—various—embryonic, muscle, Cell Research, Ottawa other adult Hospital Research Institute

Ruel, Marc University of Ottawa U. Ottawa ON Stem cells—various—mesenchymal and Heart Institute endothelial progenitor; Tissue engineering

Sabourin, Luc Ottawa Hospital U. Ottawa ON Stem cells—various—embryonic, adult Research Institute Sauvageau, Guy Institute for Research U. Montréal QC Stem cells—various—hematopoietic, in Immunology and embryonic Cancer Seguin, Cheryle U. Western ON Stem cells—various—pluripotent, neural Ontario Stanford, William U. Toronto ON Stem cells—various—pluripotent— induced pluripotent, embryonic; Mesenchymal Turksen, Kursad Sprott Centre for Stem U. Ottawa ON Stem cells—various—embryonic, Cell Research, Ottawa epidermal Health Research Institute Yang, Xiang-Jiao McGill U. QC Stem cells—various Zandstra, Peter McEwen Centre U. Toronto ON Stem cells—various including embryonic, for Regenerative hematopoietic Medicine, University Health Network and Institute of Biomaterials and Biomedical Engineering, Donnelly Centre

116 appendiX 3C. RESEARCHERS ACCORDING TO DISEASE FOCUS 3

3c. Researchers According to Disease Focus universitY/ disease researCHer researCH institution institution provinCe desCription aging Yang, Xiang-Jiao McGill U. QC Aging CanCer Allan, Alison London Regional Cancer U. Western Ontario ON Cancer—breast Program, London Health Sciences Centre Anderson, Michele Sunnybrook Research Institute U. Toronto ON Cancer—leukemia, lymphoma Annabi, Borhane U. Québec à Montréal QC Cancer Aparicio, Samuel BC Cancer Agency U. British Columbia BC Cancer—breast Barabé, Frédéric U. Laval QC Cancer—leukemia Beausejour, Christian Hôpital Sainte-Justine U. Montréal QC Cancer (Montréal) Ben-David, Yaacov Sunnybrook Research Institute U. Toronto ON Cancer—leukemia Bijl, Janetta U. Montréal QC Cancer—leukemia Bramson, Jonathan McMaster U. ON Cancer Brinkman, Ryan Terry Fox Laboratory, BC U. British Columbia BC Cancer Cancer Agency Brodt, Pnina The Research Institute of McGill U. QC Cancer the McGill University Health Centre Couban, Stephen Dalhousie U. NS Cancer— hematological Crump, Michael A. Ontario Cancer Institute, U. Toronto ON Cancer—lymphoma University Health Network Dankort, David McGill U. QC Cancer DeCoteau, John U. Saskatchewan Sask Cancer Dedhar, Shoukat BC Cancer Agency U. British Columbia BC Cancer Dennis, James W. Samuel Lunenfeld Research U. Toronto ON Cancer, other Institute, Mount Sinai Hospital Dick, John McEwen Centre for U. Toronto ON Cancer, incl. leukemia Regenerative Medicine and Ontario Cancer Institute, University Health Network

Dirks, Peter Hospital for Sick Children U. Toronto ON Cancer—brain Doble, Bradley Stem Cell and Cancer McMaster U. ON Cancer Research Institute Doyle, John U. Toronto ON Cancer Eaves, Allen Terry Fox Laboratory, BC U. British Columbia BC Cancer—leukemia Cancer Agency Eaves, Connie Terry Fox Laboratory, BC U. British Columbia BC Cancer Cancer Agency

117 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3c. Cont’d universitY/ disease researCHer researCH institution institution provinCe desCription Egan, Sean Hospital for Sick Children U. Toronto ON Cancer—breast Emery, Gregory U. Montréal QC Cancer Emili, Andrew The Donnelly Centre—Banting U. Toronto ON Cancer and Best Department of Medical Research Gassas, Adam Hospital for Sick Children U. Toronto ON Cancer—leukemia Geyer, Ronald U. Saskatchewan Sask Cancer Ghanekar, Anand U. Toronto ON Cancer—liver Giacomantonio, Carman A. Dalhousie U. NS Cancer Grant, Denis U. Toronto ON Cancer Guidos, Cynthia Hospital for Sick Children U. Toronto ON Cancer—leukemia Hassell, John McMaster U. ON Cancer Hedley, David William Ontario Cancer Institute, U. Toronto ON Cancer—cervical University Health Network Hicks, Geoffrey Cancer Care Manitoba— U. Manitoba MB Cancer Institute of Cell Biology Hill, Richard Ontario Cancer Institute, U. Toronto ON Cancer—cervical University Health Network Hoang, Trang Institute for Research in U. Montréal QC Cancer—leukemia Immunology and Cancer Hogge, Donna Terry Fox Laboratory, BC U. British Columbia BC Cancer—leukemia Cancer Agency Hombach-Klonisch, Sabine U. Manitoba MB Cancer Hope, Kristin Jill Stem Cell and Cancer McMaster U. ON Cancer—leukemia Research Institute Huang, Annie Hospital for Sick Children U. Toronto ON Cancer—brain Iscove, Norman McEwen Centre for U. Toronto ON Cancer—leukemia Regenerative Medicine, and Ontario Cancer Institute, University Health Network

Jiang, Xiaoyan Terry Fox Laboratory, BC U. British Columbia BC Cancer—leukemia Cancer Agency Jirik, Frank Southern Alberta Cancer U. Calgary AB Cancer Research Institute Jolicoeur, Paul Institut de recherches U. Montréal QC Cancer cliniques de Montréal Kamnasaran, Deepak U. Laval QC Cancer—brain Kaplan, David Hospital for Sick Children U. Toronto ON Cancer Karsan, Aly BC Cancer Agency U. British Columbia BC Cancer—leukemia

Keating, Armand U. Toronto ON Cancer— hematological Klonisch, Thomas CancerCare Manitoba U. Manitoba MB Cancer

118 appendiX 3C. RESEARCHERS ACCORDING TO DISEASE FOCUS 3

universitY/ disease researCHer researCH institution institution provinCe desCription Krystal, Gerald Terry Fox Laboratory, BC U. British Columbia BC Cancer Cancer Agency Kuruvilla, John Ontario Cancer Institute, U. Toronto ON Cancer— University Health Network hematological Labbé, Jean-Claude U. Montréal QC Cancer Lansdorp, Peter Terry Fox Laboratory, BC U. British Columbia BC Cancer, other Cancer Agency Lee, Patrick W.K. Dalhousie U. NS Cancer Lessard, Julie Institute for Research in U. Montréal QC Cancer— Immunology and Cancer hematological Levesque, Eric Centre hospitalier de U. Laval QC Cancer l’Université Laval Mak, Tak Ontario Cancer Institute, U. Toronto ON Cancer University Health Network Minden, Mark David Ontario Cancer Institute, U. Toronto ON Cancer—leukemia University Health Network Moroy, Tarik Institut de recherches U. Montréal QC Cancer— cliniques de Montréal hematological Munoz Risueno, Ruth Stem Cell and Cancer McMaster U. ON Cancer—leukemia Research Institute Neel, Benjamin Ontario Cancer Institute, U. Toronto ON Cancer—ovarian University Health Network Nevill, Thomas Vancouver Coastal Health U. British Columbia BC Cancer Research Institute O’Brien, Catherine Adell Ontario Cancer Institute, U. Toronto ON Cancer—colorectal University Health Network Ohasi, Pamela Sumiko Ontario Cancer Institute, U. Toronto ON Cancer University Health Network Paige, Christopher Ontario Cancer Institute, U. Toronto ON Cancer University Health Network Pilarski, Linda U. Alberta AB Cancer—multiple myeloma Postovit, Lynne-Marie U. Western Ontario ON Cancer Prakash, Satya McGill U. QC Cancer Rak, Janusz The Research Institute of McGill U. QC Cancer—brain the McGill University Health Centre Raouf, Afshin Cancer Care Manitoba— U. Manitoba MB Cancer—breast Institute of Cell Biology Reilly, Raymond Matthew U. Toronto ON Cancer—leukemia Roy, Denis-Claude Centre de recherche de U. Montréal QC Cancer—leukemia l’Hôpital Maisonneuve- Rosemont Roy, Jean Centre de recherche de U. Montréal QC Cancer—leukemia l’Hôpital Maisonneuve- Rosemont

119 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3c. Cont’d universitY/ disease researCHer researCH institution institution provinCe desCription Sauvageau, Guy Institute for Research in U. Montréal QC Cancer— Immunology and Cancer hematological; Other Schimmer, Aaron Ontario Cancer Institute, U. Toronto ON Cancer—leukemia University Health Network Schultz, Kirk Child & Family Research U. British Columbia BC Cancer—leukemia Institute Shaw, Patricia Ann Ontario Cancer Institute, U. Toronto ON Cancer University Health Network Singh, Sheila Stem Cell and Cancer McMaster U. ON Cancer—brain Research Institute Smith, Clayton Terry Fox Laboratoy, BC U. British Columbia BC Cancer— Cancer Agency hematological Song, Kevin Vancouver Coastal Health U. British Columbia BC Cancer—lymphoma Research Institute Tabori, Uri Hospital for Sick Children U. Toronto ON Cancer—brain Tang, Damu St. Joseph’s Hospital McMaster U. ON Cancer—prostate (Hamilton) Tanner, Scott U. Toronto ON Cancer Tannock, Ian Frederick Ontario Cancer Institute, U. Toronto ON Cancer University Health Network Till, Jim Ontario Cancer Institute, U. Toronto ON Cancer University Health Network Toze, Cynthia BC Cancer Agency U. British Columbia BC Cancer— hematological Wall, Donna Cancer Care Manitoba U. Manitoba MB Cancer Wells, Richard Alexander Sunnybrook Research Institute U. Toronto ON Cancer—leukemia Wong, Peggy Hospital for Sick Children U. Toronto ON Cancer—leukemia Wouters, Bradley Ontario Cancer Institute, U. Toronto ON Cancer University Health Network Wrana, Jeffrey Samuel Lunenfeld Research U. Toronto ON Cancer Institute, Mount Sinai Hospital Wynder, Christopher McMaster U. ON Cancer Zackenhaus, Eldad U. Toronto ON Cancer CardiopulMonarY Courtman, David Sprott Centre for Stem Cell U. Ottawa ON Cardiopulmonary Research, Ottawa Hospital Research Institute CardiovasCular Allan, David Sprott Centre for Stem Cell U. Ottawa ON Cardiovascular Research, Ottawa Health Research Institute Arora, Rakesh C Associated with National U. Manitoba MB Cardiology Research Council of Canada, Institute for Biological Sciences

120 appendiX 3C. RESEARCHERS ACCORDING TO DISEASE FOCUS 3

universitY/ disease researCHer researCH institution institution provinCe desCription Calderone, Angelo Montreal Heart Institute U. Montréal QC Cardiology Dick, Alexander Sunnybrook Research Institute U. Toronto ON Cardiology

Duff, Henry Joseph U. Calgary AB Cardiology Gramolini, Anthony Orlando The Donnelly Centre, Banting U. Toronto ON Cardiovascular and Best Department of Medical Research Gutkowska, Jolanta Centre de recherche du Centre U. Montréal QC Cardiology hospitalier de l’Université de Montréal Husain, Mansoor McEwen Centre for U. Toronto ON Cardiovascular Regenerative Medicine, Toronto General Research Institute, University Health Network Jackson, Michael U. Manitoba MB Cardiology Jones, Elizabeth McGill U. QC Cardiovascular Keeley, Fred Hospital for Sick Children U. Toronto ON Cardiovascular Kislinger, Thomas Ontario Cancer Institute, UHN U. Toronto ON Cardiovascular Li, Ren-Ke McEwen Centre for U. Toronto ON Cardiovascular, Regenerative Medicine, cardiology Toronto General Research Institute, University Health Network Ly, Hung Montreal Heart Institute U. Montréal QC Cardiology Megeney, Lynn Sprott Centre for Stem Cell U. Ottawa ON Cardiovascular Research, Ottawa Health Research Institute Michalak, Marek S. U. Alberta AB Cardiovascular Nemer, Mona U. Ottawa ON Cardiology Pang, Stephen Queen’s U. ON Cardiology Pasumarthi, Kishore Babu S. Dalhousie U. NS Cardiology Pelletier, Marc New Brunswick Heart Centre New Brunswick Heart NB Cardiology Centre Podor, Thomas iCapture U. British Columbia BC Cardiology Prato, Frank Lawson Health Research U. Western Ontario ON Cardiology Institute, London Health Sciences Centre Qayumi, Karim Vancouver Coastal Health U. British Columbia BC Cardiology Research Institute Radisic, Milica U. Toronto ON Cardiology Reudelhuber, Timothy Luther Institut de recherches U. Montréal QC Cardiovascular cliniques de Montréal Ruel, Marc University of Ottawa Heart U. Ottawa ON Cardiology Institute

121 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3c. Cont’d universitY/ disease researCHer researCH institution institution provinCe desCription Santerre, Paul U. Toronto ON Cardiovascular Stewart, Alexandre University of Ottawa Heart U. Ottawa ON Cardiology Institute Stewart, Duncan Sprott Centre for Stem Cell U. Ottawa ON Cardiovascular Research, Ottawa Health Research Institute Suuronen, Erik University of Ottawa Heart U. Ottawa ON Cardiology Institute Tabrizian, Maryam McGill U. QC Cardiovascular Tian, Ganghong (Hong) Associated with National U. Manitoba MB Cardiology Research Council of Canada, Institute for Biological Sciences

Tremblay, Michel L. McGill U. QC Cardiology Trigatti, Bernardo Louis McMaster U. ON Cardiovascular

Veres, Teodor U. Laval QC Cardiovascular von Harsdorf, Rudiger McEwen Centre for U. Toronto ON Cardiology Regenerative Medicine, Toronto General Research Institute, University Health Network Walker, Gilbert Creighton U. Toronto ON Cardiovascular Ward, Christopher Andrew Queen’s U. ON Cardiology Weisel, Richard Toronto General Research U. Toronto ON Cardiology Institute, University Health Network Wells, Sarah Dalhousie U. NS Cardiovascular Woodhouse, Kimberly Queen’s U. ON Cardiovascular Cutaneous McElwee, Kevin Vancouver Coastal Health U. British Columbia BC Cutaneous Research Institute Tredget, Edward Eric U. Alberta AB Cutaneous Turksen, Kursad Sprott Centre for Stem Cell U. Ottawa ON Cutaneous Research, Ottawa Health Research Institute dental Hamilton, Douglas U. Western Ontario ON Dental Tran, Simon McGill U. QC Dental Tran, Simon McGill U. QC Dental eMBrYogenesis Golding, Michael C. U. Western Ontario ON Embryogenesis Hoodless, Pamela Terry Fox Laboratory, BC U. British Columbia BC Embryogenesis Cancer Agency

122 appendiX 3C. RESEARCHERS ACCORDING TO DISEASE FOCUS 3

universitY/ disease researCHer researCH institution institution provinCe desCription Puri, Mira Sunnybrook Research Institute U. Toronto ON Embryogenesis Rossant, Janet Hospital for Sick Children U. Toronto ON Embryogenesis Smith, Lawrence C. U. Montréal QC Embryogenesis gastrointestinal Bjerknes, Matthew J. U. Toronto ON Gastrointestinal genetiC Hough, Margaret Sunnybrook Research Institute U. Toronto ON Genetic Lefebvre, Louis U. British Columbia BC Genetic HeMatologiCal Barber, Dwayne Ontario Cancer Institute, U. Toronto ON Hematological— University Health Network anemia, cancer Brand, Marjorie Sprott Centre for Stem Cell U. Ottawa ON Hematological—ß- Research, Ottawa Health thalassemia and sickle Research Institute cell anemia Carreau, Madeleine Centre hospitalier de U. Laval QC Hematological— l’Université Laval anemia Huang, Sui U. Calgary AB Hematological Humphries, Keith Terry Fox Laboratory, BC U. British Columbia BC Hematological— Cancer Agency anemia, cancer Lilicrap, David Queen’s U. ON Hematological— hemophilia Robert, François Institut de recherches U. Montréal QC Hematological cliniques de Montréal Schuh, Andre Ontario Cancer Institute, U. Toronto ON Hematological— University Health Network hemophilia Wang, Chen U. Toronto ON Hematological— anemia iMMunologiCal Denburg, Judah Aryeh McMaster U. ON Immunological— allergy, asthma Ellis, Anne Queen’s U. ON Immunological— allergy Helgason, Cheryl BC Cancer Agency U. British Columbia BC Immunological— autoimmune Lewis, James Franklin Lawson Health Research U. Western Ontario ON Immunological— Institute, London Health infl ammation Sciences Centre Schrader, John W. Biomedical Research Centre U. British Columbia BC Immunological— immunodefi ciency Zúñiga-Pfl ücker, Juan-Carlos Sunnybrook Research Institute U. Toronto ON Immunological— immunodefi ciency infeCtion—Hiv Joshi, Sadhna U. Toronto ON Infection—HIV

123 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3c. Cont’d universitY/ disease researCHer researCH institution institution provinCe desCription MetaBoliC—diaBetes Anderson, Colin C. U. Alberta AB Metabolic—diabetes Hill, David Lawson Health Research U. Western Ontario ON Metabolic—diabetes Institute, London Health Sciences Centre Horb, Markoe Institut de recherches U. Montréal QC Metabolic—diabetes cliniques de Montréal Johnson, James U. British Columbia BC Metabolic—diabetes Kieffer, Tim U. British Columbia BC Metabolic—diabetes Korbutt, Gregory Alberta Diabetes Institute U. Alberta AB Metabolic—diabetes; other Lynn, Francis U. British Columbia BC Metabolic—diabetes Rajotte, Raymond V. U. Alberta AB Metabolic—diabetes Rosenberg, Lawrence The Research Institute of McGill U. QC Metabolic—diabetes the McGill University Health Centre Verchere, Bruce U. British Columbia BC Metabolic—diabetes Vermette, Patrick U. Sherbrooke QC Metabolic—diabetes Warnock, Garth Vancouver Coastal Health U. British Columbia BC Metabolic—diabetes Research Institute MusCulosKeletal Akimenko, Marie-Andrée Ottawa Hospital Research U. Ottawa ON Musculoskeletal Institute Alman, Benjamin Hospital for Sick Children U. Toronto ON Musculoskeletal Antoniou, John Jewish General Hospital McGill U. QC Musculoskeletal Aubin, Jane U. Toronto ON Musculoskeletal Barralet, Jake McGill U. QC Musculoskeletal— bone formation Brunette, Donald Biomedical Research Centre U. British Columbia BC Musculoskeletal Burt, Helen Mary Biomedical Research Centre U. British Columbia BC Musculoskeletal Buschmann, Michael École polytechnique de QC Musculoskeletal— Montréal cartilage cell delivery Catelas, Isabelle U. Ottawa ON Musculoskeletal— bone loss Davies, John U. Toronto ON Musculoskeletal— bone Dilworth, Jeffrey Sprott Centre for Stem Cell U. Ottawa ON Musculoskeletal: Research, Ottawa Health Duchenne Research Institute Faucheux, Nathalie U. Sherbrooke QC Musculoskeletal— bone and cartilage regeneration Ferguson, Peter Charles Mount Sinai Hospital U. Toronto ON Musculoskeletal

124 appendiX 3C. RESEARCHERS ACCORDING TO DISEASE FOCUS 3

universitY/ disease researCHer researCH institution institution provinCe desCription Fernlund, Goran U. British Columbia BC Musculoskeletal Filiaggi, Mark J. Dalhousie U. NS Musculoskeletal— bone Fradette, Julie LOEX U. Laval QC Musculoskeletal Frei, Hanspeter Carleton U. ON Musculoskeletal— bone Goulet, Francine LOEX U. Laval QC Musculoskeletal Grenier, Guillaume U. Sherbrooke QC Musculoskeletal— muscle Harvey, Edward McGill U. QC Musculoskeletal— bone Hawke, Thomas McMaster U. ON Musculoskeletal— muscle Hoemann, Caroline École polytechnique de QC Musculoskeletal Montréal Hunter, Christopher U. Calgary AB Musculoskeletal—disc Johnston, James U. Saskatchewan Sask Musculoskeletal Kandel, Rita Samuel Lunenfeld Research U. Toronto ON Musculoskeletal Institute, Mount Sinai Hospital Langelier, Eve U. Sherbrooke QC Musculoskeletal Matyas, John Robert U. Calgary AB Musculoskeletal Merrifi eld, Peter U. Western Ontario ON Musculoskeletal Mwale, Fackson Jewish General Hospital, Lady McGill U. QC Musculoskeletal—disc Davis Institute Nanci, Antonio U. Montréal QC Musculoskeletal Nazhat, Showan McGill U. QC Musculoskeletal Paquin, Joanne U. Québec à Montréal QC Musculoskeletal Parise, Gianni McMaster U. ON Musculoskeletal Pilliar, Robert U. Toronto ON Musculoskeletal— bone; Dental Pouliot, Roxane LOEX U. Laval QC Musculoskeletal Putnins, Edward U. British Columbia BC Musculoskeletal Puymirat, Jack U. Laval QC Mysculoskeletal myotonic dystrophy Quinn, Thomas McGill U. QC Musculoskeletal— cartilage, ligaments Rancourt, Derrick U. Calgary AB Musculoskeletal Reinhardt, Dieter McGill U. QC Musculoskeletal Tanentzapf, Guy U. British Columbia BC Musculoskeletal

Toyserkani, Ehsan U. Waterloo ON Musculoskeletal Tremblay, Jacques Centre hospitalier de U. Laval QC Musculoskeletal— l’Université Laval muscular dystrophy

125 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3c. Cont’d universitY/ disease researCHer researCH institution institution provinCe desCription Tufenkji, Nathalie McGill U. QC Musculoskeletal Underhill, Michael U. British Columbia BC Musculoskeletal Waldman, Stephen Queens U. ON Musculoskeletal Whyne, Cari Sunnybrook Research Institute U. Toronto ON Musculoskeletal Wiper-Bergeron, Nadine Louise U. Ottawa ON Musculoskeletal Yahia, L’Hocine École polytechnique de QC Musculoskeletal Montréal neurologiCal Antel, Jack McGill U. QC Neurological—multiple sclerosis Aviv, Tzvi Hospital for Sick Children U. Toronto ON Neurological Bani, Mahmud Associated with National U. Ottawa ON Neurological—brain Research Council of Canada, injury Institute for Biological Sciences Bennett, Steffany U. Ottawa ON Neurological, incl. Alzheimer’s Biernaskie, Jeffrey A. Associated with Hotchkiss U. Calgary AB Neurological—injury, Brain Institute wound healing Cao, Xudong U. Ottawa ON Neurological—spinal cord, eye Carrier, Patrick LOEX U. Laval QC Eye Cayouette, Michel Institut de recherches U. Montréal QC Neurological, including cliniques de Montréal eye Chen, Daniel (Xiongbiao) U. Saskatchewan Sask Neurological— peripheral Cheng, Hai-Ling Margaret Sunnybrook Research Institute U. Toronto ON Neurological—stroke Chow, Bob U. Victoria BC Eye Cregan, Sean John P. Robarts Research U. Western Ontario ON Neurological Institute Dekaban, Gregory John P. Robarts Research U. Western Ontario ON Neurological—spinal Institute cord injury Drouin, Jacques Institut de recherches U. Montréal QC Neurological— cliniques de Montréal Parkinson’s Dyck, Richard Henry Associated with Hotchkiss U. Calgary AB Neurological—brain Brain Institute Fehlings, Michael McEwen Centre for U. Toronto ON Neurological—spinal Regenerative Medicine cord injury and McLaughlin Centre for Molecular Medicine, Toronto Western Research Institute, University Health Network Fernandes, Karl U. Montréal QC Neurological— neurodegenerative diseases, incl. Alzheimer’s 126 appendiX 3C. RESEARCHERS ACCORDING TO DISEASE FOCUS 3

universitY/ disease researCHer researCH institution institution provinCe desCription Giasson, Claude J. LOEX affi liation U. Montréal QC Eye Gregory-Evan, Kevin Vancouver Coastal Health U. British Columbia BC Eye Research Institute Griffi th, May Sprott Centre for Stem Cell U. Ottawa ON Eye Research, Ottawa Health Research Institute Hazell, Alan Stewart Centre de recherche du Centre U. Montréal QC Neurological—brain hospitalier de l’Université de injury Montréal Hui, Chi-chung Hospital for Sick Children U. Toronto ON Neurological Karimi-Abdolrezaee, Soheila U. Manitoba MB Neurological—spinal cord injury Kim, Seung Vancouver Coastal Health U. British Columbia BC Neurological Research Institute Krieger, Charles Simon Fraser U. BC Neurological Kwon, Brian U. British Columbia BC Neurological—spinal cord injury Lagace, Diane U. Ottawa ON Neurological Laposa, Rebecca U. Toronto ON Neurological Leavitt, Blair Centre for Molecular Medicine U. British Columbia BC Neurological & Therapeutics Lecanu, Laurent The Research Institute of McGill U. QC Neurological the McGill University Health Centre Levin, Leonard Centre de recherche de U. Montréal QC Eye l’Hôpital Maisonneuve- Rosemont Meakin, Susan John P. Robarts Research U. Western Ontario ON Neurological Institute Mendez, Ivar Dalhousie U. NS Neurological Metz, Luanne Associated with Hotchkiss U. Calgary AB Neurological—multiple Brain Institute sclerosis Midha, Rajiv Associated with Hotchkiss U. Calgary AB Neurological Brain Institute Miller, Freda McEwen Centre for U. Toronto ON Neurological, incl. Regenerative Medicine, spinal cord injury Toronto General Research Institute, University Health Network

Morshead, Cindi U. Toronto ON Neurological, other Pilon, Nicolas U. Québec à Montréal QC Neurological Rafuse, Victor Dalhousie U. NS Neurological, including Parkinson’s, ALS Rastegar, Mojgan U. Manitoba MB Neurological, cancer- brain

127 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3c. Cont’d universitY/ disease researCHer researCH institution institution provinCe desCription Rivest, Serge Centre hospitalier de U. Laval QC Neurological l’Université Laval Roskams, Jane U. British Columbia BC Neurological— olfactory Schuurmans, Carol Associated with Hotchkiss U. Calgary AB Neurological—stroke, Brain Institute spinal cord injury, eye Slack, Ruth Ottawa Hospital Research U. Ottawa ON Neurological Institute Stanisz, Greg Sunnybrook Research Institute U. Toronto ON Neurological

Stifani, Stefano Montreal Neurological McGill U. QC Neurological—ALS Institute Tator, Charles Toronto General Research U. Toronto ON Neurological—spinal Institute, University Health cord injury Network Tetzlaff, Wolfram U. British Columbia BC Neurological—spinal cord injury Tropepe, Vince U. Toronto ON Neurological development Tsai, Eve Sprott Centre for Stem Cell U. Ottawa ON Neurological—spinal Research, Ottawa Health cord injury Research Institute Tsilfi dis, Catherine Sprott Centre for Stem Cell U. Ottawa ON Eye Research, Ottawa Health Research Institute van der Kooy, Derek McEwen Centre for U. Toronto ON Neurological—brain; Regenerative Medicine, Eye Toronto General Research Institute, University Health Network Vanderluit, Jacqueline Memorial U. NL Neurological Wallace, Valerie Sprott Centre for Stem Cell U. Ottawa ON Eye Research, Ottawa Health Research Institute Weiss, Samuel Associated with Hotchkiss U. Calgary AB Neurological—brain, Brain Institute olfactory Yong, Von Wee Associated with Hotchkiss U. Calgary AB Neurological—multiple Brain Institute sclerosis renal Eliopoulos, Nicoletta Jewish General Hospital, Lady McGill U. QC Renal Davis Institute for Medical Research reproduCtion Casper, Robert Samuel Lunenfeld Research U. Toronto ON Reproduction—female Institute, Mount Sinai Hospital fertility

128 appendiX 3C. RESEARCHERS ACCORDING TO DISEASE FOCUS 3

universitY/ disease researCHer researCH institution institution provinCe desCription Cross, James Charles U. Calgary AB Reproduction—female Dobrinski, Ina U. Calgary AB Reproduction—male Dufort, Daniel McGill U. QC Reproduction— implantation Farookhi, Riaz McGill U. QC Reproduction—ovary Li, Julang U. Guelph ON Reproduction—female; Other Nagano, Makoto The Research Institute of McGill U. QC Reproduction—male the McGill University Health Centre

Robaire, Bernard McGill U. QC Reproduction—male; Other respiratorY Downey, Gregory U. Toronto ON Respiratory Post, Martin Hospital for Sick Children U. Toronto ON Respiratory Thebaud, Bernard U. Alberta AB Respiratory Waddell, Thomas McEwen Centre for U. Toronto ON Respiratory—lung Regenerative Medicine, transplant Toronto General Research Institute, University Health Network soCial sCienCes & HuManities Baylis, Françoise Dalhousie U. NS SSH: Ethics Bubela, Tania U. Alberta AB SSH: Socioeconomic benefi ts Caulfi eld, Tim U. Alberta AB SSH: Ethics and law Chandler, Jennifer U. Ottawa ON SSH: Law, policy Daar, Abdallah McLaughlin-Rotman Centre U. Toronto ON SSH: Ethics and law for Global Health, University Health Network Einsiedel, Edna U. Calgary AB SSH: Social science Glass, Kathleen McGill U. QC SSH: Ethics, legal Illes, Judy U. British Columbia BC SSH: Ethics Ingram, Liz U. Alberta AB SSH: Social Knoppers, Bartha McGill U. QC SSH: Ethics, law, policy Leibing, Annette U. Montréal QC SSH: Social Lemmens, Trudo U. Toronto ON SSH: Law Leroux, Therese U. Montréal QC SSH: Policy McDonald, Michael U. British Columbia BC SSH: Ethic

Menon, Devidas U. Alberta AB SSH: Policy von Tigerstrom, Barbara U. Saskatchewan Sask SSH: Law

129 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3c. Cont’d universitY/ disease researCHer researCH institution institution provinCe desCription urologiCal El-Hakim, Assaad McGill U. QC Urological Farhat, Walid Hospital for Sick Children U. Toronto ON Urological various Acker, Jason U. Alberta AB Various Amsden, Brian Queens U. ON Various Atkins, Harry Sprott Centre for Stem Cell U. Ottawa ON Various, incl. cancer— Research, Ottawa Health hematopoietic, Research Institute neurological—MS Audet, Julie Institute of Biomaterials and U. Toronto ON Various Biomedical Engineering Auger, François A. LOEX U. Laval QC Various, incl. cardiovascular, transplantation, injury Bader, Gary Institute of Biomaterials and U. Toronto ON Various Biomedical Engineering Barrett, Christopher McGill U. QC Various Behie, Leo Includes: Pharmaceutical U. Calgary AB Various—neurological, Production Research Facility metabolic—diabetes Berthod, François LOEX U. Laval QC Various, incl. neurological, urological, cutaneous Betts, Dean U. Western Ontario ON Various Bhatia, Mickie Stem Cell and Cancer McMaster U. ON Various, incl. Research Institute respiratory—lung disease Brash, John McMaster U. ON Various Chang, Thomas Ming Swi Artifi cial Cells and Organs McGill U. QC Various, incl. Research Centre cardiovascular Chen, Jie U. Alberta AB Various De Crescenzo, Gregory École polytechnique de QC Various— Montréal musculoskeletal, cardiovascular Doillon, Charles U. Laval QC Various— cardiovascular, cancer Draper, Jonathan Stem Cell and Cancer McMaster U. ON Various Research Institute Dumont, Dan Sunnybrook Research Institute U. Toronto ON Various— cardiovascular, cancer Duval, Michel U. Montréal QC Various Elliott, Janet Anne Wade U. Alberta AB Various Ellis, James Hospital for Sick Children U. Toronto ON Various, incl. neurological, incl. Rett’s; Hematological— anemia

130 appendiX 3C. RESEARCHERS ACCORDING TO DISEASE FOCUS 3

universitY/ disease researCHer researCH institution institution provinCe desCription Favis, Basil École polytechnique de QC Various Montréal Figeys, Daniel U. Ottawa ON Various Flynn, Lauren Queen’s U. ON Various Garnier, Alain U. Laval QC Various Germain, Lucie LOEX U. Laval QC Various, incl. cutaneous, cardiovascular, eye Ghanem, Amyl Dalhousie U. NS Various Greenblatt, Jack The Donnelly Centre, Banting U. Toronto ON Various and Best Department of Medical Research Hansen, David U. Calgary AB Various Hebert, Marie-Josee Centre de recherche du Centre U. Montréal QC Various—renal, hospitalier de l’Université de cardiovascular Montréal Hess, David John P. Robarts Research U. Western Ontario ON Various— Institute cardiovascular; Metabolic—diabetes Heveker, Nikolaus Hôpital Sainte-Justine U. Montréal QC Various Hoare, Todd McMaster U. ON Various Hughes, Timothy The Donnelly Centre—Banting U. Toronto ON Various and Best Department of Medical Research Jervis, Eric U. Waterloo ON Various Jolicoeur, Mario École polytechnique de QC Various Montréal Jones, Kim McMaster U. ON Various, incl. immunological Julius, Michael Sunnybrook Research Institute U. Toronto ON Various, incl. immunological, cancer, infection Kaern, Mads U. Ottawa ON Various Kallos, Michael Includes: Pharmaceutical U. Calgary AB Various Production Research Facility Kamacheva, Eugenia U. Toronto ON Various Keller, Gordon McEwen Centre for U. Toronto ON Various, incl. Regenerative Medicine and hematological, Ontario Cancer Institute, cardiovascular University Health Network

Kelly, Kevin Francis Stem Cell and Cancer McMaster U. ON Various, incl. Research Institute cutaneous, cancer Khan, Zia U. Western Ontario ON Various Ko, Frank U. British Columbia BC Various

131 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3c. Cont’d universitY/ disease researCHer researCH institution institution provinCe desCription Kothary, Rashmi K. Ottawa Hospital Research U. Ottawa ON Various, incl. Institute neurological, cardiovascular Kreplak, Laurent Dalhousie U. NS Various Krylov, Sergey N. York U. ON Various Lacroix, Dan LOEX U. Laval QC Various Lajoie, Gilles U. Western Ontario ON Various; Proteomics Larouche, Danielle LOEX U. Laval QC Various Legge, Raymond U. Waterloo ON Various Levy, Gary Toronto General Research U. Toronto ON Various, incl. Institute, University Health immunological Network Marra, Marco BC Cancer Agency, Genome U. British Columbia BC Various Sciences Centre Marshall, Aaron U. Manitoba MB Various Massie, Bernard Associated with National U. Montréal QC Various, incl. Research Council— hematological— Biotechnology Research hemophilia Institute

McBurney, Michael Ottawa Hospital Research U. Ottawa ON Various—aging, Institute cancer McGann, Locksley Earl U. Alberta AB Various McGuigan, Alison Institute of Biomaterials and U. Toronto ON Various Biomedical Engineering McInnes, Roderick Jewish General Hospital, Lady McGill U. QC Various, incl. eye Davis Institute McKerlie, Colin Samuel Lunenfeld Research U. Toronto ON Various Institute, Mount Sinai Hospital McNagny, Kelly Biomedical Research Centre U. British Columbia BC Various— allergy, asthma, cardiovascular, hematological, neurological Mequanint, Kibret U. Western Ontario ON Various Moffat, Jason The Donnelly Centre U. Toronto ON Various Mollica, Luigina Centre de recherche de U. Montréal QC Various l’Hôpital Maisonneuve- Rosemont Morris, Quaid The Donnelly Centre, Banting U. Toronto ON Various and Best Department of Medical Research Moulin, Véronique LOEX U. Laval QC Various

132 appendiX 3C. RESEARCHERS ACCORDING TO DISEASE FOCUS 3

universitY/ disease researCHer researCH institution institution provinCe desCription Nagy, Andras Samuel Lunenfeld Research U. Toronto ON Various, incl. cancer Institute, Mount Sinai Hospital and McEwen Centre for Regenerative Medicine, University Health Network Opas, Michal J. U. Toronto ON Various— musculoskeletal, cardiovascular Park, Edward U. Victoria BC Various Perkins, Theodore Sprott Center for Stem Cell U. Ottawa ON Various Research, Ottawa Health Research Institute

Piret, James Michael Smith Laboratories U. British Columbia BC Various Ramsay, Bruce Queens U. ON Various Rogers, Ian Samuel Lunenfeld Research U. Toronto ON Various, including Institute, Mount Sinai Hospital diabetes Rossi, Fabio Biomedical Research Centre U. British Columbia BC Various Rottapel, Robert Ontario Cancer Institute, U. Toronto ON Various University Health Network Rudnicki, Michael Sprott Centre for Stem Cell U. Ottawa ON Various, incl. Research, Ottawa Hospital neuromuscular Research Institute Sabourin, Luc Ottawa Hospital Research U. Ottawa ON Various Institute Santamaria, Pere U. Calgary AB Various, incl. immunological, metabolic—diabetes Savard, Pierre U. Laval QC Various Sefton, Michael The Donnelly Centre U. Toronto ON Various Seguin, Cheryle U. Western Ontario ON Various, incl. metabolic, musculoskeletal, embryogenesis Sen, Arindom U. Calgary AB Various Sheardown, Heather McMaster U. ON Various—eye, cardiovascular Shoichet, Molly McEwen Centre for U. Toronto ON Various—neurological: Regenerative Medicine, Spinal cord injury, eye; Toronto General Research Cancer Institute, University Health Network

Simmons, Craig U. Toronto ON Various—cardiology; Musculoskeletal— bone Skerjanc, Ilona Sylvia U. Ottawa ON Various— cardiovascular, musculoskeletal

133 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3c. Cont’d universitY/ disease researCHer researCH institution institution provinCe desCription Stanford, William U. Toronto ON Various, incl. musculoskeletal— osteoporosis Sun, Yu U. Toronto ON Various Turner, Robin Michael Smith Laboratories U. British Columbia BC Various

Tyndale, Rachel U. Toronto ON Various Unsworth, Larry U. Alberta AB Various Vincent, Michel U. Laval QC Various— cardiovascular, musculoskeletal Walus, Konrad U. British Columbia BC Various— musculoskeletal, cutaneous Wang, Lisheng U. Ottawa ON Various Wertheimer, Michel Robert École polytechnique de QC Various Montréal Woodgett, James Samuel Lunenfeld Research U. Toronto ON Various, incl. cancer, Institute, Mount Sinai Hospital metabolic—diabetes, neurological Yip, Christopher The Donnelly Centre U. Toronto ON Various Zandstra, Peter McEwen Centre for U. Toronto ON Various, incl. Regenerative Medicine, hematological University Health Network and Institute of Biomaterials and Biomedical Engineering, Donnelly Centre Zhang, Ze U. Laval QC Various Ziltener, Hermann Johann Biomedical Research Centre U. British Columbia BC Various

134 appendiX 3D. EXAMPLES OF RESEARCHERS WORKING IN TRANSLATIONAL MEDICINE AND/OR CLINICAL TRIALS 3

3d. Examples of Researchers Working in Translational Medicine and/or Clinical Trials researCH universitY/ researCHer institution institution provinCe tYpe of regen. Med disease Atkins, Harry Sprott Centre for Stem U. Ottawa ON Stem cells—hematopoietic Various, incl. cancer— Cell Research, Ottawa hematopoietic, Health Research neurological—MS Institute Aubin, Jane U. Toronto ON Stem cells—mesenchymal Musculoskeletal

Behie, Leo Includes: U. Calgary AB Bioprocessing—stem cells Various—neurological, Pharmaceutical production/ culture metabolic—diabetes Production Research Facility Berthod, François LOEX U. Laval QC Tissue engineering—stem Various, incl. cells neurological, urological, cutaneous Bramson, Jonathan McMaster U. ON Stem cells—cancer Cancer

Couban, Stephen Dalhousie U. NS Stem cells—cord blood Cancer— hematological Courtman, David Sprott Centre for Stem U. Ottawa ON Stem cells—adult— Cardiopulmonary Cell Research, Ottawa endothelial progenitor Hospital Research Institute Crump, Michael A. Ontario Cancer U. Toronto ON Stem cells—hematopoietic Cancer—lymphoma Institute, University Health Network Dekaban, Gregory John P. Robarts U. Western ON Stem cells—unspecifi ed Neurological—spinal Research Institute Ontario cord injury Doyle, John U. Toronto ON Stem cells—hematopoietic Cancer

Drouin, Jacques Institut de recherches U. Montréal QC Stem cells—fetal Neurological— cliniques de Montréal Parkinson’s Gassas, Adam Hospital for Sick U. Toronto ON Stem cells—hematopoietic Cancer—leukemia Children Griffi th, May Sprott Centre for Stem U. Ottawa ON Biomaterials—scaffolds; Eye Cell Research, Ottawa Tissue engineering—stem Health Research cells Institute Kaplan, David Hospital for Sick U. Toronto ON Stem cells—cancer Cancer Children Keating, Armand U. Toronto ON Stem cells—bone marrow— Cancer— mesenchymal, hematopoietic hematological Kuruvilla, John Ontario Cancer U. Toronto ON Stem cells—unspecifi ed Cancer— Institute, University hematological Health Network Kwon, Brian U. British BC Stem cells—unspecifi ed Neurological—spinal Columbia cord injury Levesque, Eric Centre hospitalier de U. Laval QC Stem cells—hematopoietic Cancer l’Université Laval

135 LISTS OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 3 RESEARCHERS

3d. Cont’d researCH universitY/ researCHer institution institution provinCe tYpe of regen. Med disease Levy, Gary Toronto General U. Toronto ON Stem cells—various— Various, incl. Research Institute, unspecifi ed immunological University Health Network Mendez, Ivar Dalhousie U. NS Stem cells—fetal Neurological Metz, Luanne Associated with U. Calgary AB Stem cells—adult— Neurological—multiple Hotchkiss Brain endogenous progenitor sclerosis Institute Miller, Freda McEwen Centre for U. Toronto ON Stem cells—various—dermal, Neurological, incl. Regenerative Medicine, neural spinal cord injury Toronto General Research Institute, University Health Network Morshead, Cindi U. Toronto ON Stem cells—neural Neurological, other

Rogers, Ian Samuel Lunenfeld U. Toronto ON Stem cells—various—cord Various, including Research Institute, blood, induced pluripotent, diabetes Mount Sinai Hospital bone marrow

Roy, Denis-Claude Centre de recherche de U. Montréal QC Stem cells—cancer Cancer—leukemia l’Hôpital Maisonneuve- Rosemont Schimmer, Aaron Ontario Cancer U. Toronto ON Stem cells—cancer Cancer—leukemia Institute, University Health Network Schultz, Kirk Child & Family U. British BC Stem cells—hematopoietic Cancer—leukemia Research Institute Columbia Schuurmans, Carol Associated with U. Calgary AB Stem cells—unspecifi ed Neurological—stroke, Hotchkiss Brain spinal cord injury, eye Institute Slack, Ruth Ottawa Hospital U. Ottawa ON Stem cells—unspecifi ed Neurological Research Institute Song, Kevin Vancouver Coastal U. British BC Stem cells—hematopoietic Cancer—lymphoma Health Research Columbia Institute Stewart, Duncan Sprott Centre for Stem U. Ottawa ON Stem cells—adult Cardiovascular Cell Research, Ottawa Health Research Institute Tannock, Ian Frederick Ontario Cancer U. Toronto ON Stem cells—cancer Cancer Institute, University Health Network Toze, Cynthia BC Cancer Agency U. British BC Stem cells—bone marrow Cancer— Columbia hematological Tropepe, Vince U. Toronto ON Stem cells—neural Neurological development

136 appendiX RESEARCH CENTRES LISTED BY PROVINCE 4

researCH universitY/ researCHer institution institution provinCe tYpe of regen. Med disease researCH universitY/ researCHer institution institution provinCe tYpe of regen. Med disease Tsai, Eve Sprott Centre for Stem U. Ottawa ON Stem cells—unspecifi ed Neurological—spinal Cell Research, Ottawa cord injury Levy, Gary Toronto General U. Toronto ON Stem cells—various— Various, incl. Health Research Research Institute, unspecifi ed immunological Institute University Health Network van der Kooy, Derek McEwen Centre for U. Toronto ON Stem cells—neural (incl. Neurological—brain; Regenerative Medicine, retinal) Eye Mendez, Ivar Dalhousie U. NS Stem cells—fetal Neurological Toronto General Metz, Luanne Associated with U. Calgary AB Stem cells—adult— Neurological—multiple Research Institute, Hotchkiss Brain endogenous progenitor sclerosis University Health Institute Network Miller, Freda McEwen Centre for U. Toronto ON Stem cells—various—dermal, Neurological, incl. Wall, Donna Cancer Care Manitoba U. Manitoba MB Stem cells—hematological Cancer Regenerative Medicine, neural spinal cord injury Toronto General Weiss, Samuel Associated with U. Calgary AB Stem cells—neural Neurological—brain, Research Institute, Hotchkiss Brain olfactory University Health Institute Network Wong, Peggy Hospital for Sick U. Toronto ON Stem cells—cancer Cancer—leukemia Morshead, Cindi U. Toronto ON Stem cells—neural Neurological, other Children

Rogers, Ian Samuel Lunenfeld U. Toronto ON Stem cells—various—cord Various, including Research Institute, blood, induced pluripotent, diabetes appendiX 4 Research Centres Listed By Province Mount Sinai Hospital bone marrow provinCe/ departMent/affiliated # asset Map # endoWed # puBs/sCi. universitY institution url researCHers CHairs iMpaCt * Roy, Denis-Claude Centre de recherche de U. Montréal QC Stem cells—cancer Cancer—leukemia l’Hôpital Maisonneuve- alBerta 37 5 Rosemont U. Alberta All www.ualberta.ca 16 4 116/1.7 Schimmer, Aaron Ontario Cancer U. Toronto ON Stem cells—cancer Cancer—leukemia Alberta Diabetes Institute www.adi.med.ualberta.ca 1 0 N/A Institute, University Health Network Other 15 4 Schultz, Kirk Child & Family U. British BC Stem cells—hematopoietic Cancer—leukemia U. Calgary All www.ucalgary.ca 21 1 60/1.6 Research Institute Columbia Hotchkiss Brain Institute www.hbi.ucalgary.ca 7 0 N/A Schuurmans, Carol Associated with U. Calgary AB Stem cells—unspecifi ed Neurological—stroke, Pharmaceutical Production www.pprf.ca 2 1 N/A Hotchkiss Brain spinal cord injury, eye Research Facility Institute Southern Alberta Cancer Research www.sacri.ucalgary.ca 1 0 N/A Slack, Ruth Ottawa Hospital U. Ottawa ON Stem cells—unspecifi ed Neurological Institute Research Institute Other 11 0 Song, Kevin Vancouver Coastal U. British BC Stem cells—hematopoietic Cancer—lymphoma Health Research Columbia BritisH ColuMBia 53 8 Institute Simon Fraser U. All www.sfu.ca 1 0 N/A Stewart, Duncan Sprott Centre for Stem U. Ottawa ON Stem cells—adult Cardiovascular U. British All www.ubc.ca 50 7 121/1.3 Cell Research, Ottawa Columbia Health Research Institute BC Cancer Agency (BCCA) (excl. www.bccancer.bc.ca 6 1 83/1.9 Terry Fox Laboratory) Tannock, Ian Frederick Ontario Cancer U. Toronto ON Stem cells—cancer Cancer Institute, University Biomedical Research Centre www.brc.ubc.ca 6 1 N/A Health Network Centre for Molecular Medicine & www.cmmt.ubc.ca 1 0 N/A Toze, Cynthia BC Cancer Agency U. British BC Stem cells—bone marrow Cancer— Therapeutics Columbia hematological Child & Family Research Institute www.cfri.ca 1 0 N/A Tropepe, Vince U. Toronto ON Stem cells—neural Neurological iCapture www.icapture.ubc.ca 1 0 N/A development Michael Smith Labs www.michaelsmith.ubc.ca 2 0 N/A

137 LIST OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 4 RESEARCH CENTRES

appendiX 4 Cont’d provinCe/ departMent/affiliated # asset Map # endoWed # puBs/sCi. universitY institution url researCHers CHairs iMpaCt * Terry Fox Labs, BCCA www.terryfoxlab.ca 10 1 N/A Vancouver Coastal Health Research www.vchri.ca 7 0 N/A Institute Other 2 0 U. Victoria All www.uvic.ca 2 1 N/A ManitoBa 11 2 U. Manitoba All www.umanitoba.ca 11 2 N/A Cancer Care Manitoba (incl. www.cancercare.mb.ca; 4 1 N/A Institute of Cell Biology) www.umanitoba.ca/institutes/ manitoba_institute_cell_biology Other 7 1 neW BrunsWiCK 1 0 All (New Brunswick Heart Centre) www.ahsc.health.nb.ca 1 0 N/A neWfoundland & laBrador 1 0 Memorial U. All www.mun.ca 1 0 N/A nova sCotia 11 1 Dalhousie U. All www.dal.ca 11 1 N/A ontario 195 41 Carleton U. All www.carleton.ca 1 0 McMaster U. All www.mcmaster.ca 19 5 75/1.1 St. Joseph’s Hospital www.stjosham.on.ca 1 0 N/A Stem Cell and Cancer Research sccri.mcmaster.ca 7 4 N/A Institute (SCC-RI) Other 11 1 Queen’s U. All www.queensu.ca 9 1 N/A U. Guelph All www.uoguelph.ca 1 0 N/A U. Ottawa All www.uottawa.ca 34 9 N/A Ottawa Hospital Research Institute www.ohri.ca 5 1 N/A (OHRI) (excl. Sprott Centre) Sprott Centre for Stem Cell www.ohri.ca/centres/ 14 5 N/A Research, OHRI StemCellResearch University of Ottawa Heart Institute www.ottawaheart.ca 3 1 N/A Other 11 2 U. Toronto All www.utoronto.ca 110 24 173/1.5 McLaughlin-Rotman Centre for www.mrcglobal.org 1 0 N/A Global Health, University Health Network (UHN) Mount Sinai Hospital www.mountsinai.on.ca 1 0 N/A

138 appendiX RESEARCH CENTRES LISTED BY PROVINCE 4

provinCe/ departMent/affiliated # asset Map # endoWed # puBs/sCi. universitY institution url researCHers CHairs iMpaCt * The Donnelly Centre (Terrance thedonnellycentre.utoronto.ca 8 2 N/A Donnelly Centre for Cellular and Biomolecular Research) (incl. Banting and Best Department of Medical Research) Hospital for Sick Children www.sickkids.ca 16 4 47/1.2 Institute of Biomaterials and www.ibbme.utoronto.ca 3 0 N/A Biomedical Engineering McEwen Centre for Regenerative www.mcewencentre.com 12 6 N/A Medicine, Toronto General Research Institute, UHN Ontario Cancer Institute (Princess www.uhnresearch.ca/institutes/ 19 1 N/A Margaret Hospital), UHN oci Samuel Lunenfeld Research www.lunenfeld.ca 8 3 N/A Institute, Mount Sinai Hospital Sunnybrook Research Institute sunnybrook.ca/research 12 1 N/A Toronto General Research Institute www.uhnres.utoronto.ca/ 3 0 N/A (excl. McEwen Centre), UHN institutes/tgri Other 27 7 U. Waterloo All www.uwaterloo.ca 3 0 N/A U. Western All www.uwo.ca 17 1 N/A Ontario John P. Robarts Research Institute www.robarts.ca 4 1 N/A Lawson Health Research Institute, www.lawsonresearch.com 3 0 N/A London Health Sciences Centre London Regional Cancer Program, www.lrcc.on.ca 1 0 N/A London Health Sciences Centre Other 9 0 York U. All www.yorku.ca 1 1 N/A QueBeC 102 24 École All www.polymtl.ca 7 3 N/A polytechnique de Montréal McGill U. All www.mcgill.ca 33 8 89/1.1 Artifi cial Cells and Organs Research www.medicine.mcgill.ca/artcell 1 0 N/A Centre Jewish General Hospital incl. www.jgh.ca 2 1 N/A Lady Davis Institute for Medical Research Montreal Neurological Institute 1 0 N/A The Research Institute of the McGill muhc.ca 5 0 N/A University Health Centre Other 24 7 U. Laval All www.ulaval.ca 23 1 Centre hospitalier de l’Université www.crchuq.ulaval.ca 4 0 N/A Laval

139 LIST OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 4 RESEARCH CENTRES

appendiX 4 Cont’d provinCe/ departMent/affiliated # asset Map # endoWed # puBs/sCi. universitY institution url researCHers CHairs iMpaCt * LOEX (Experimental Organogenesis www.cha.quebec.qc.ca/en/ 10 1 N/A Laboratory—Laboratoire www/research/fi elds-of- d’organogénèse expérimentale) research www.loex.qc.ca Other 9 0 U. Montreal All www.umontreal.ca 32 10 N/A Centre de recherche de l’Hôpital recherche.maisonneuve- 3 2 N/A Maisonneuve-Rosemont rosemont.org Centre de recherche du Centre www.chumtl.qc.ca/crchum. 3 0 N/A hospitalier de l’Université de en.html Montréal Hôpital Sainte-Justine www.chu-sainte-justine.org 2 0 N/A Institut de recherches cliniques de www.ircm.qc.ca 7 3 N/A Montréal Institute for Research in www.iric.ca 3 3 N/A Immunology and Cancer Montreal Heart Institute www.icm-mhi.org 2 0 N/A Other 10 2 U. Québec à All www.international.uqam.ca/ 3 1 N/A Montréal pages/anglais.aspx U. Sherbrooke All www.usherbrooke.ca 4 1 N/A sasKatCHeWan 5 0 U. Saskatchewan All www.usask.ca 5 0 N/A

*Publications and scientifi c impact data were produced by Industry Canada in 2010 in a report titled Mapping Canadian BioPharmaceutical Assets. Data were collected from 1996–2009. For the Scientifi c Impact rating, the global average is 1.0.

140 appendiX REFERENCES AND NOTES 5 general inforMation 7 Canadian Scientists Transform Human • US National Institutes of Health. Skin into Blood. www.canada.com/ Regenerative Medicine. Department of story_print.html?id=3793787&sponsor=. Health and Human Services. August Accessed November 24, 2010. 2006. stemcells.nih.gov/info/2006report/. Accessed January 21, 2011. 8 Editorial. Betting on HSC. Nature Immunology. 2002: 3. Cited in Stem Cell endnotes Network. Book Two: Strategic Plan for 1 Stem Cell Basics. National Institutes of Second Funding Cycle 2007. Provided by Health. stemcells.nih.gov/info/basics/. Drew Lyall. Accessed January 21, 2011. 9 ISI index reference. Cited in Stem Cell 2 Till, JE, McCulloch, EA. A direct Network. Book Two: Strategic Plan for measurement of the radiation sensitivity Second Funding Cycle 2007. Provided by of normal mouse bone marrow cells. Drew Lyall. Radiation Res. 1961; 14, 213–222; Becker AJ, McCulloch EA, Till JE. 10 Ontario’s MaRS Regenerative Medicine Cytological demonstration of the clonal 2009 Industry Briefi ng report. nature of spleen colonies derived from www.marsdd.com/buzz/reports/ transplanted mouse marrow cells. Nature. regenerativemedicine. Accessed 1963; 197:452–454. November 17, 2010.

3 Stem Cell Network. Book Two: Strategic 11 Technology, talent and capital: State Plan for Second Funding Cycle 2007. Bioscience Initiatives 2008. Battelle Provided by Drew Lyall. Memorial Institute and Biotechnology Industry Organization. www.bio.org/ 4 www.stemcellnetwork.ca. Accessed local/battelle2008/State_Bioscience_ December 16, 2010. Initiatives_2008.pdf. Accessed February 23, 2011. 5 (1) www.stemcellnetwork.ca. Accessed December 16, 2010; (2) Lyall, A, Isasi, R. 12 States applaud new stem cell funding. Stem Cell Research: Perspectives from March 11, 2009. www.stateline.org/live/ Canada. World Stem Cell Report details/story?contentId=383210. Accessed 2010. Chapter 11. pp. 173–177. www. February 23, 2011. worldstemcellsummit.com/node/663. Accessed December 16, 2010. (3) 13 (1) See reference #11. Also (2) Industry Canada. Fitzpatrick, Meagan. Canada’s mantle as stem-cell leader fading, experts warn. 6 (1) Stem Cell Network. Book Two: November 2, 2010. www.canada.com/ Strategic Plan for Second Funding story_print.html?id=3766795&sponsor=. Cycle 2007. Provided by Drew Lyall. (2) Accessed November 24, 2010. (3) Industry Canada. Evidence to Standing Committee on

141 LIST OF CANADIAN STEM CELLS AND REGENERATIVE MEDICINE 5 RESEARCH CENTRES

Health Nov 2, 2010. www2.parl.gc.ca/ 19 v(1) www.canada.com/health/Funding HousePublications/Publication.aspx?L +only+remaining+obstacle+national anguage=E&Mode=1&Parl=40&Ses= +cord+blood+bank/3877607 /story. 3&DocId=4750819&File=0. Accessed html#ixzz16EF5Hh40. Accessed December 15, 2010. January 28, 2011. (2) Evidence to Standing Committee on Health 14 All NCE funds were dedicated to Nov 2, 2010. www2.parl.gc.ca/ U. Ottawa where the Stem Cell Network HousePublications/Publication.aspx? (SCN) is located. A breakdown of funds Language=E&Mode=1&Parl=40&Ses= according to SCN grants across Canada 3&DocId=4750819&File=0. Accessed would have made some diﬀ erence December 15, 2010. Note: there was to provincial and university funding an announcement on March 14, 2011 (Figures 2 and 3), although this generally that governments had agreed to fund a would not have been signifi cant except national blood bank with $48 million for U. Ottawa. Even so, this university over the next 9 years with operations would still have ranked among the top expected from 2013. See “National cord fi v .e blood bank to get $48M”. CBC News March 14, 2011. www.cbc.ca. Accessed 15 Stem Cell Basics. National Institutes of March 17, 2011. Health. stemcells.nih.gov/info/basics/. Accessed January 21, 2011. 20 www.bccancer.bc.ca/NR/rdonlyres/ 41981E57-778D-4E85-82E2- 16 Shapiro, A.M., J.R. Lakey, E.A. Ryan, et al. 58D8EE5C16D8/33204/Headlines_ Islet transplantation in seven patients Spring_2009.pdf. Accessed February 3, with type 1 diabetes mellitus using a 2011. glucocorticoid-free immunosuppressive regimen. N Engl J Med. 2000; 343:230– 21 Ontario’s MaRS Regenerative Medicine 38. Cited in Lyall, A. Investment Asset Map 2009. www.trra.ca/en/sectors/ Models 3: Public Investment In Stem Cell resources/MRI_asset_maps_RM_050809. Research In Canada. pdf. Accessed December 15, 2010.

17 Stem Cell Network. Stem cells for the 22 Stem Cell Banks, Libraries and Registries. treatment of Parkinson’s disease project. Stem Cell Network. (Page 4). www. www.stemcellnetwork.ca. Accessed stemcellnetwork.ca/uploads/File/ February 7, 2011. whitepapers/Stem-Cell-Banks-Libraries- and-Registries.pdf. Accessed February 3, 18 www.suite101.com/content/ 2011. cord-blood-banking-university- research-in-canada-a274345; www. 23 Ontario’s MaRS Regenerative Medicine cordbloodassociationofcanada.com/ Asset Map 2009. www.trra.ca/en/sectors/ Cord_Blood_Banking.php; Accessed resources/MRI_asset_maps_RM_050809. January 28, 2011. pdf. Accessed December 15, 2010.

142 appendiX REFERENCES AND NOTES 5

24 www.nce-rce.gc.ca/Media-Medias/news- sciverse.com/UserFiles/2508.SciVerse. communiques/News-Communique_eng. Research Performance Measurement(LR). asp?ID=93. Accessed January 10, 2011. pdf. Accessed January 11, 2011). (2) Report by Science-Metrix for Industry 25 www.cancerstemcellconsortium.com/ Canada 2010: Performance of Canadian uploads/PDFs/CSCC.Full.Str.Plan FINAL Biopharmaceutical Organizations: A REVISED 18 November 2008_Corrected Scientometric and Technometric Analysis Date.pdf. Accessed January 10, 2011. (1996–2009), dated March 31, 2010.

26 Information from: stemcells. 29 Canadian Scientists Transform Human nih.gov/research/intlresearch. Skin into Blood. www.canada.com/ asp, www.vr.se/inenglish/aboutus/ story_print.html?id=3793787&sponsor=. internationalcollaboration/ Accessed November 24, 2010. globalcollaboration/international stemcellforumiscf.4.aad30e310ab 30 Ontario—a leading centre of stem cell cb9735780006480.html. Accessed research. Biotechnology Focus. 2008; February 3, 2011. June: 22–25.

27 Data were obtained from the fi rst 50 hits 31 Nagy, A., J. Rossant, R. Nagy, et al. from Google searches naming province, Derivation of completely cell culture- “research network”, or “research group”. derived mice from early-passage embryonic stem cells. Proc Natl Acad 28 (1) Mapping Canadian BioPharmaceutical Sci USA. 1993; 90(18): 8424–28. Cited Assets: Academic and Hospital in Lyall, A. Investment Models 3: Public Research Institutes (September 2010), Investment In Stem Cell Research In internal document provided by Life Canada. Science Industries Branch at Industry Canada. Citation data source: Scopus, 32 Nagy, A., J. Rossant, R. Nagy, et al. Website: www.scopus.com. Explanation: Derivation of completely cell culture- Researchers were selected using a formula derived mice from early-passage based on number of papers and citation embryonic stem cells. Proc Natl Acad counts in regenerative medicine and stem Sci U S A. 1993; 90(18): 8424–28. Cited cells from 2005 to 2010. Self-citations in Lyall, A. Investment Models 3: Public were excluded. Citation index (h-index) Investment In Stem Cell Research In quantifi es the impact of a researcher’s Canada. publications. So an h-index of 16 means that the top 16 of a researcher’s articles 33 Mapping Canadian BioPharmaceutical were cited 16 or more times; an h-index Assets: Academic and Hospital Research of 12 means that the top 12 articles Institutes (September 2010), internal were cited 12 or more times (Research document provided by Industry Canada’s Performance Measurement: Introducing Life Science Industries Branch. the SciVerse Scopus h-index). Report published August 2007. www.info.

143

appendiX 4A. RESEARCHERS IN ALPHABETICAL ORDER 4

145