Royal Free London NHS Foundation Trust Open Studies

R&D No Short Title Sponsor Organisation Principal Investigator EuroSIDA HIV/AIDS 10 year Eurpean cohort - European Virology co-ordinating 5162 Centre for Health and Infectious Disease Research Professor Clive Loveday centre (2000-2004) 5658 Fabry outcome survey [FOS] Shire Human Genetic Therapies UK Ltd Dr Derralynn Hughes

6339 Clinical pancreatic islet transplantation in patients with insulin dependent diabetes. The Royal Free Hospital Dr Martin Press Elucidating the pathogenesis of systemic sclerosis by studying skin, blood and 6398 Royal Free London NHS Foundation Trust Prof Carol M Black tissue samples from s Non-invasive prenatal diagnosis of haemophilia using free fetal DNA in maternal 6441 Royal Free London NHS Foundation Trust Miss Rezan A Abdul-Kadir plasma. British Regional Heart Study (BRHS). Strategies for the prevention of cardiovascular 6755 University College London Professor P Whincup disease in olde Database of patients with movement disorders and prospective collection and 6540 UCL Dr Anette Schrag storage of DNA samples. 6884 The Investigation of the cause and the mechanism of Immunodeficiency diseases. Royal Free London NHS Foundation Trust Prof Bodo Grimbacher Bilibaby- The Relationship Between Neonatal Scleral Tone and Serum Bilirubin 6899 UCL Dr Alastair. Sutcliffe Levels. 7190M Identification and molecular analyses of families with susceptibility to breast cancer. ICR Dr James Mackay The Gaucher Registry: an ongoing, observational database that tracks the natural 7266M Genzyme Corporation Professor Atul B Mehta history and outcome An observational study of HIV infected persons in the UK for whom the time of HIV 7324 MRC Regional Centre London Professor Margaret A Johnson seroconversion is Apples: A prospective paediatric longitudinal evaluation to assess the long term 7375 Astellas Pharma Europe Dr Mahreen Ameen; Dr Ian Pollock safety of tacrolimu 7379 PG-SNPS: The pharmacogenetics of early Breast Cancer chemotherapy Cambridge University Hospitals NHS Foundation Trus David Jones 7409 UK National Barrett's Oesophagus Registry UCL Dr Christine Caygill 7432 MRC SUPREMO Lothian Health Board Dr Sarah Needleman Prospective comparison of transient elastography (FibroScan) and transjugular liver 7435 Royal Free London NHS Foundation Trust Dr Emmanouil Tsochatzis biopsy ("gold st Fabry Registry; an ongoing, observational database that tracks the natural history 7437 Royal Free London NHS Foundation Trust Professor Atul B Mehta and outcomes of p Pompe Registry;an on going, observational database tracking the natural history 7438 Royal Free London NHS Foundation Trust Dr Derralynn Hughes and outcomes of pati BILCAP A randomised clinical trial evaluating adjuvant chemotherapy with 7488 University of Southampton Professor Tim Meyer capecitabine compared to ex National Registry of Babies, Infants and Children Under 5 Treated for Congenital 7534 UCL Paul David Griffiths Cytomegalovirus (CM Clinico-pathological correlation of liver histopathology, scoring systems and 7558 Royal Free London NHS Foundation Trust Professor A Paul Dhillon histochemistry, electr 7584 Carcinoid Heart Disease- Serotonin Receptor Analysis Royal Free London NHS Foundation Trust Dr Dimitiri P Mikhailidis 7592M TRANSBIL UCLH Research Governance Unit Dr James S Dooley TeloVac-A prospective, controlled, multicentre, randomised clinical trial comparing 7606M University of Liverpool Professor Tim Meyer combination Gemc An Open-Label extension trial of UT-15C SR in subjects with Pulmonary Arterial 7609M United Therapeutics Europe Ltd Dr Gerry J Coghlan Hypertension Surveillance for asymptomatic carriage of abnormal prions in primary 7615M University of Edinburgh Prof Bodo Grimbacher; Dr J Buckland immunodeficiency patients expos New EPOC: A prospective Randomised Open Label Trial of 7624M Southampton University Hospital NHS Trust Dr Astrid Mayer Oxaliplatin/Fluoropyrimidine versus Oxaliplat The Investigation of genetic disorders in families with immunodeficiencies across 7632 Royal Free London NHS Foundation Trust Prof Bodo Grimbacher clinical centres Predicting CD4 cell count slopes in HIV infected patients: the effects of virological 7639 Royal Free London NHS Foundation Trust Dr Anna Maria Geretti and immunologi Warfarin Anticoagulation for liver fibrosis in patients transplanted for Hepatitis C 7657M Imperial College London Professor Andrew K Burroughs virus infection Royal Free London NHS Foundation Trust Open Studies

R&D No Short Title Sponsor Organisation Principal Investigator

7662 Peripheral Neuropathy in Alcohol Misusers: Prevalence, Nature and Natural History Royal Free London NHS Foundation Trust Dr Marsha Y Morgan

7664M AVAST-M Cambridge University Hospitals NHS Foundation Trus Dr Amna Sheri 7676M FOxTROT University of Birmingham Dr Astrid Mayer 7697M PIVOT Study MRC Professor Margaret A Johnson 7699 Healthy Control Samples Royal Free London NHS Foundation Trust Dr Matthew Buckland 7701M National Study of Colorectal Cancer Genetics The Institute of Cancer Research Dr Astrid Mayer Tumour Angiogenesis in Breast Cancer: Correlation between FDG PET, Contrast 7702M UCL Mr Daren Frances Enhanced MRI, CT and His 7704M PBC Genetics Study Addenbrooke's Hospital Dr Steve Mann; Dr Douglas Thorburn 7727 Identification of genes involved in renal and electrolyte disorders Royal Free London NHS Foundation Trust Prof Robert Kleta 7728M Predictive utility of DASIMAR as prognostic Biomarker in ACLF and ALF University College London Hospital Professor Raj Mookerjee; Professor Rajiv Jalan 7750 Capsule endoscopy vs OGD for dyspepsia Royal Free London NHS Foundation Trust Professor Owen Epstein 7758 Pilot Study to explore the role of acceptance in cancer rehabilitation UCL Dr Adrian J Tookman 7759 ET-RAs in Bowel Cancer Royal Free London NHS Foundation Trust Mr O A Ogunbiyi 7760 Prevalence of Anderson-Fabry Disease in at risk populations UCL Dr Derralynn Hughes 7769M MPSI Registry Genzyme Europe BV Dr Derralynn Hughes 7786M SCOT NHS Greater Glasgow and Clyde Dr Astrid Mayer 7788M Studies of EBV-associated NK/T-cell diseases & formation of a registry University of Birmingham Dr Kate Cwynarski 7791 Epigenetic and genetic studies of Neuroendocrine Tumours v1.0 Royal Free London NHS Foundation Trust Professor Martyn Caplin 7803 Efficacy of Micropulse Trabeculoplasty Royal Free London NHS Foundation Trust Mr Vikas Sharma 7810M STAMPEDE (version 1.0) -PR08 MRC Clincal Trials Unit Cancer Group Dr Maria Vilarino-Varela 7814M POETIC Royal Marsden NHS Trust Dr Jacqueline Newby 7832M Immunology bacteriology laryngitis Royal Free London NHS Foundation Trust Mr Martin Birchall 7836 AL chemo therapy study Alchemy Royal Free London NHS Foundation Trust Dr Julian Gillmore 7845 HIV Renal Study Pharmacy Department, Royal free Hospital Miss Esther Nyanganyi-Gathogo 7849M Cardio Vascular Disease in adult haemophilia patients STH Research & Department, STH research Department Dr Pratima Chowdary 7851M UK-PSC Addenbrooke's Hospital Dr Douglas Thorburn; Dr Steve Mann 7866M BADBIR The University of Manchester Dr Mahreen Ameen 7867M UKGPCS Institute of Cancer ResearchRoyal Cancer Hospital Dr Maria Vilarino-Varela; Dr Ursula McGovern 7868M WT1 TCR Gene therapy University College London Dr Emma C Morris 7879M A40001067 POEM Study Pfizer Inc Professor Margaret A Johnson 7883M IMPORT HIGH Cambridge Cancer Research Fund Dr Sarah Needleman 7886M Molecular genetic studies of familial movement disorders UCLH Research Governance Unit Mr John S Rubin 7888M Genetic investigation of inherited kidney Disease UCL Dr H Maxwell 7895M Haemophilia gene transfer St. Jude Children's Research Hospital Prof Amit Nathwani 7896M Biomedical and quality of life assessment in Type 1 Diabetes Newcastle upon Tyne NHS Trust Miranda Rosenthal 7914 Strategic Timing of AntiRetroviral Treatment (START) Regents of the University of Minnesota Professor Margaret A Johnson

7912 Post-marketing observational registry of Humira in Psoriasis patients ESPRIT Study AbbVie Inc. Dr Sandra McBride

7931 Fresh Frozen Plasma in Liver Disease Royal Free London NHS Foundation Trust Dr Pratima Chowdary European Trial of Free Light Chain Removal by Extended Haemodialysis in Cast 7943 University Hospitals Birmingham NHS Foundation Tru Dr Julian Gillmore Nephropathy (EuLITE) 7947 European Study Group for Pancreatic Cancer (ESPAC) - Trial 4 University of Liverpool Professor Tim Meyer 7950 SMART Database University College London Professor Chris Denton 7965 ELUCIDATE Liver Cirrhosis Study University of Leeds Dr Douglas Thorburn 7969 SHIFT University of Leeds Turan Huseyin; Dr Ameet Bakhai Royal Free London NHS Foundation Trust Open Studies

R&D No Short Title Sponsor Organisation Principal Investigator 7981 Immunogenetics of Vasculitis v2 Ipswich Hospital Dr Mark Little 7989 Joints manifestations in Anderson-Fabry disease Cardiff University Dr Derralynn Hughes 7991 Pulmonary Substudy: A Substudy of START Regents of University of Minnesota Professor Margaret A Johnson 7995 Study of the aetiology and prodrome of parkinson's disease University of Liverpool Professor Anthony HV Schapira 7992 The Research Tissue Bank, university of Bradford University of Bradford Mrs Sandra Martin 7317 ESID Online patient and research Database UK Primary Immunodeficiency Network (UKPIN) Dr Matthew Buckland 8013 Immune Monitoring Study Royal Free London NHS Foundation Trust Professor H J Stauss 8018 Studies of peripheral nerve function Royal Free London NHS Foundation Trust Dr R W Orrell 8020 Models of Medical Leadership and their Effectiveness University of Birmingham PROF Chris Ham 8023 Immune responses in Hepatocellular Cancer v1.0 Royal Free London NHS Foundation Trust Dr Roopinder Gilmore 8050 Observational study of early diffuse SSc The University of Manchester Professor Chris Denton 8060 Medical Device Design and use in the Haematology / Oncology Day Unit Royal Free London NHS Foundation Trust Dr Astrid Mayer 8070 TACE-2 UCL Professor Tim Meyer 8075 Study of transmission risk between HIV discordant partners UCL Dr Alison Rodger 8087 Liver Viability Enhancement during Transportation (LIVET) UCL Professor Brian R Davidson 8095 European recurrent fever study UCL Dr. Helen J. Lachmann

8111 Investigating genes in patients with polymyositis and dermatomyositis - MYOSIS University of Manchester Dr Voon Hong Ong

8117 RAPPER The University of Manchester Dr Maria Vilarino-Varela 8122 CompERA Hammersmith Hospital Dr Gerry J Coghlan 8131 Using Genetics to Understand Parkinson's Disease University College London Hospitals NHS Foundation Professor Anthony HV Schapira 8132 Defining risk factors for tenofovir induced kidney injury version 1.0 King's College London Professor Margaret A Johnson 8135 Cochlear Dead Regions and Tinnitus: Is there a link? Royal Free London NHS Foundation Trust Miss Sotira Katiri 8143 Predisposition to serrated neoplasia and tumours (PRESENT) study University of Oxford Dr marco Novelli 8147 Prevention of infection in cirrhosis with L. casei Shirota Version 4.0 UCL Professor Rajiv Jalan 8148 The PROBE C Study New and Emerging Applications in Technology- NEAT Dr Sanjay Bhagani 8159 Reverse remodelling of pulmonary vasculopathy UCL Dr Gerry J Coghlan 8171 CUP - ONE Cancer Research UK Centre for Epidermology Dr Roopinder Gillmore 8172 ARTemis Cambridge University Hospitals NHS Foundation Trus Dr Jacqueline Newby

8179 IDEA - Rapid Identification via Interferon Gamma test for Active Tuberculosis Imperial College London Dr Marc Lipman

8191 Remote Ischaemic Preconditioning and Outcome of Liver Transplantation Royal Free London NHS Foundation Trust Professor Brian R Davidson

8193 Evaluation of effect of ACE inhibitors on small aneurysm growth rate Imperial College London Dr Meryl Davis 8199 Circulating angiogenic cytokines in portal hypertension UCL Professor William Rosenberg Evaluation of global haemostasis assays for predicting the FFP transfusion in 8204 Royal Free London NHS Foundation Trust Dr Pratima Chowdary patients on intensive 8210 Cognitive Impairment in People with HIV in the European Region (CIPHER) UCL Dr Alison Rodger

8211 EUROPAC - FPC University of Liverpool Prof Stephen P Pereira 8221 Pilot Study Of Obeticholic Acid In Portal Hypertension Intercept Pharmaceuticals Professor Raj Mookerjee 8242 GammaTrack GAM 1006 Octapharma Ltd Professor Bodo Grimbacher 8263 CARMENA NHS Greater Glasgow and Clyde Mr Michael Aitchison 8275 RituxiCAN-C4 Kings College London Dr Peter Dupont 8290 Disease biomarkers in amyotrophic lateral sclerosis [ALS Biomarkers] Barts and The London NHS Trust Dr R W Orrell 8293 Bone Mineral Density in Haemophilia Version 1 Basingstoke and North Hampshire Hospital NHS Foundation Dr Pratima Chowdary 8300 UK Vasculitis Susceptibility and Outcomes University of Oxford Prof Alan Salama 8304 DH PRP PRE PREGNANCY HEALTH & CARE (V.1) UCL Emma Hardwick Royal Free London NHS Foundation Trust Open Studies

R&D No Short Title Sponsor Organisation Principal Investigator 8306 The MRC/ABPI COPD Cohort v 1.6 Imperial College London Professor Jadwiga Wedzicha 8307 Abnormal genes and proteins in inflammatory bowel disease UCL Dr Mark Furman 8308 Biliary Tract Cancer QoL Validation Basingstoke and North Hampshire NHS Foundation Trust Dr Roopinder Gillmore 8313 Abcellute Tissue Bank Abcellute Tissue Bank Professor Brian R Davidson 8336 Inherited platelet conditions version 1 NHS Blood and Transplant Dr Charles Keith R Gomez 8337 HCV Research UK V1 Nottingham Integrated Clinical Research Centre Professor William Rosenberg 8341 MRI assessment of liver haemodynamics UCLH Professor Raj Mookerjee 8349 Progression of atherosclerosis in diabetic subjects PROCEED British Cardiac Research Trust Dr Roby Rakhit; Dr Mark Cohen 8351 Immune responses in chronic viral hepatitis UCL Professor William Rosenberg

8352 PRoBaND: Parkinson's Repository of Biosamples and Network Datasets NHS Greater Glasgow and Clyde Professor Huw Morris

8353 Predicting Serious Drug Side Effects in Gastroenterology ( PRED4 PRED 4) Royal Devon and Exeter Foundation Trust Dr Charles Murray; Dr Steve Mann

8364 The Effects of Ageing on the Cutaneous Immune System UCL Dr Mahreen Ameen 8371 Cochleotoxicity monitoring using extended high frequency audiometry Royal Free London NHS Foundation Trust Miss Sotira Katiri 8382 Genetics of colorectal tumours [CORGI 1] University of Oxford Professor Brian R Davidson 8386 NN7088-3860 Efficacy and Safety of N8GP during Surgery in Haem A Novo Nordisk Ltd Dr Pratima Chowdary 8387 NN7088-3859 Trial Evaluating Safety and Efficacy of N8-GP in Haem A Novo Nordisk Ltd Dr Pratima Chowdary 8394 ECLIPSE Extension Study Cambridge University Hospitals NHS Foundation Trus Professor Jadwiga Wedzicha 8397 A review of liver resection rate in metastatic colorectal cancer RESECT Merck Serono Ltd Professor Brian R Davidson 8407 Liver Fibrosis Progression: A Substudy of START MRC Regional Centre London Professor Margaret A Johnson 8413 POUT The Institute of Cancer Research Dr Maria Vilarino-Varela 8415 PEGASUS: Eliciting patients' expectations of breast reconstruction University of the West of England, Bristol Dr Alexandra Clarke 8421 GWAS in children with DDH Great Ormond Street Hospital Children NHS Trust Miss Olivia Malaga-Shaw 8422 Predicting unstable atheroma using FDG-PET/CT UCLH Mr Obiekezie Agu 8429 Coagulation changes in Gauchers and Fabrys disorders Royal Free London NHS Foundation Trust Dr Derralynn Hughes 8432 Peri-operative Chemotherapy & Bevacizumab in Gastric Cancer (ST03) Medical Research Council Dr Astrid Mayer

8439 efficacy & safety of pazopanib as adjuvant therapy in renal cancer [PROTECT] Novartis Pharma Dr Katia Boleti

8445 The repeatability and reliability of preoperative CPET UCLH Mr Alasdair O'Doherty 8450 Surtime European Organisation for Research and Treatment o Dr Ekaterini Boleti 8451 A study of major system reconfiguration in stroke services University College London Dr Angus Ramsay 8462 ENCEPH UK - Prospective Cohort Study University Of Liverpool Dr Dianne Irish 8467 The Loss of Consciousness Key (LOCK) scale version Royal Free London NHS Foundation Trust Dr Heather Angus-Leppan Molecular mechanism and Pathways of Chronic inflammatory and degenerative 8481 University of Oxford Mr Nobert V. Kang diseases 8483 A qualitiative study of positive adjustment following a heart attack Royal Free London NHS Foundation Trust Dr Fran Smith 8491 Immunological and Virological Evaluation of ME/CFS version 1 London School of Hygiene & Tropical Medicine Dr Ronnie Chee 8502 BACCHUS UCL Dr Rob Glynne-Jones 8506 Frail and Elderly Patient Outcomes on Dialysis (FEPOD): Part 2 Imperial College London Dr Andrew Davenport 8511 Peruse: Global safety study with pertuzumab in Her2+ advanced BC Roche Products Ltd Jackie Newby 8519 PD-CRAFT Keele University Dr Andrew Davenport 8524 A-PREDICT The Institute of Cancer Research Dr Ekaterini Boleti 8526 VIP Version: 4 University of Liverpool Dr Roopinder Gillmore 8540 MEK116513 Dabrafenib plus trametinib vs vemurafinib in melanoma Novartis Pharma Dr Amna Sheri 8546 TAILoR: TelmisArtan and InsuLin Resistance in HIV University of Liverpool Professor Margaret A Johnson 8549 The 2012 TYA Cancer Cohort Study (BRIGHTLIGHT) UCL Dr Anita Amadi Royal Free London NHS Foundation Trust Open Studies

R&D No Short Title Sponsor Organisation Principal Investigator 8556 CVID NRH Royal Free London NHS Foundation Trust Dr Ronnie Chee 8557 AALPHI version 2 Medical Research Council Dr Sabine Kinloch-de-Loes 8570 MR-CPEX in Cardiovascular Health and Disease Great Ormond Street Hospital NHS Foundation Trust Dr Gerry J Coghlan 8576 European Adrenal Insufficiency Registry (EU-AIR) 0918400 Viropharma Professor Pierre-Marc Gilles Bouloux 8577 STRASS (EORTC 62092-22092) EORTC (European Organisation for Research and Treatment of Cancer Quality] Mr Anjun Shankar

8578 Changing cytokine profiles in anti-TNF responders and non responders,1 Queen Mary University of London Dr Pamela Mangat

8580 Open Label Extension Study Oral UT-15C for PAH United Therapeutics Corporation Dr Gerry J Coghlan 8581 Oral UT-15C for treatment of Pulmonary Arterial Hypertension (PAH) United Therapeutics Corporation Dr Gerry J Coghlan

8591 Study of Carfilzomib with Dexamethasone Vs Velcade with Dexamethasone Onyx Therapeutics, Inc. Professor Atul B Mehta

8594 Gene therapy for WAS Genethon Dr Emma C Morris 8626 Study of Dexamethasone in Patients with AL Amyloidosis Millennium Millenium Pharmaceuticals Inc Dr Ashutosh Wechalekar 8629 aHUS Registry Alexion Pharmaceuticals, Inc. Dr Daniel Gale 8636 The HALT Hepatitis Study UCL Professor William Rosenberg 8644 UCL Infection DNA Bank UCL Paul David Griffiths 8666 AVATARS UCL Prof Alan Salama 8669 Fabry imaging and neuropsychology observational study (FINO study) Joint UCLH/UCL Biomedical Research (R&D) Unit Dr Derralynn Hughes 8672 ASSertID A Study of Sertraline In Dialysis East & North Hertfordshire NHS Trust Dr Andrew Davenport 8675 A study of ISIS 420915 in patients with Amyloid Polyneuropathy Isis Pharmaceuticals, Inc. Dr Carol Whelan 8676 Collection of Urine for protein purification Version 1 Scipac Ltd NO PI 8679 Cardiovascular Disease in Chronic Kidney Disease Version Great Ormond Street Hospital for Children NHS Trus Dr David Wheeler 8680 Streamline C UCL Dr Dominic Yu [Yue]; Dr Matthew Train 8687 Genetics of papillary kidney cancers University of Oxford Dr Katia Boleti 8697 Preventable unplanned admission rates University of Sheffield Tony Ewart; Sarah Perry 8708 Immuno-regulatory mechanisms in Autoimmune Disease UCL Miranda Rosenthal 8709 Size of the HIV1 University College London Professor Margaret A Johnson 8716 Toxicity from Anti-TNF Therapy (BSRBR-RA) University of Manchester Professor Chris Denton; Dr Caroline Smith 8727 MK3475 compared to Ipilimumab in Patients with Advanced Melanoma MSD Ltd Dr Amna Sheri 8734 A Low FODMAP diet Royal Free London NHS Foundation Trust Miss Tara Whyand 8735 Pazopanib in patients with renal cancer (PaZ02) University of Birmingham Dr Katia Boleti 8741 Gaucher Outcomes Survey [GOS] Shire Pharmaceuticals Limited Dr Derralynn Hughes 8744 Personalized AntiTNF Therapy in Crohn's Disease (PANTS) Royal Devon and Exeter Foundation Trust Dr Charles Murray 8748 Characterisation of CTCs and cDNA in patients with cancer UCL Professor Tim Meyer 8751 HIVCORE003;version 1.0 UCL Dr Julian Gillmore

8752 Alternative assessments of adequacy dialysis in patients with kidney failure Royal Free London NHS Foundation Trust Dr Andrew Davenport

8753 PIVOT Neurocognitive Function sub-study Medical Research Council Professor Margaret A Johnson 8765 Psychosexual functioning, fertility, and menopause in women with HIV Royal Free London NHS Foundation Trust Dr Aoife Molloy 8768 Influence of infant dietary patterns on allergy development University of Southampton Dr Giuseppina Rotiroti 8772 The London Alpha-1-Antitrypsin Deficiency Cohort Royal Free London NHS Foundation Trust Prof David Lomas 8774 The UCL BioResource version 1 UCL Prof Hans Stauss 8775 Bone specific alkaline phosphatase and outcome in dialysis patients East Kent Hospitals UNFT Dr David Wheeler Prognostic value of CT/PET in patients with interstitial lung disease: radiology-lung 8780 PIC UCL Professor Massimo Pinzani function 8784 Genes for CMV Royal Free London NHS Foundation Trust Dr Sheila Lumley; Dr Keira Skolimowska 8792 Late onset depression: Correlates of dopaminergic function UCL Dr Anette Schrag Royal Free London NHS Foundation Trust Open Studies

R&D No Short Title Sponsor Organisation Principal Investigator 8795 Ethics of Split Livers University of Birmingham Dr James O'Beirne

8797 An evaluation of phaeochromocytoma and paragangliomas management Barts and The London NHS Trust Dr Bernard Khoo

8810 National Cohort study of Idiopathic and Heritable Pulmonary Arterial Hypertension University of Cambridge Dr Gerry J Coghlan

8813 Transgenerational aspects of PCOS Royal Free London NHS Foundation Trust Mr Paul J Hardiman 8823 National guidance for measuring assistive technology Brunel University Dr Georgia Spiliotopoulou 8830 National study of membranoproliferative glomerulonephritis The Newcastle upon Tyne Hospitals NHS Foundation Trust Dr Daniel Gale 8839 Developing a Patient Decision Aid and Measure for Dialysis Choice University of Leeds Ms Sheila Johnston 8844 R4RA Queen Mary University of London Dr Richard Stratton 8846 PIVOTAL King's College Hospital NHS Foundation Trust Dr Stephen B Walsh 8847 A study of practices, knowledges and experiences of HIV treatment. The Economic and Social Research Council via Goldsmiths Ms Agata Pacho 8849 06/EuPatch University of Leicester Mr Saurabh Jain 8854 HIV Bioresource UCL Dr Fiona M Burns 8859 Machine Learning Analysis of Electronically Stored Blood Test Results UCL Dr Daniel Martin; Dr Tony Wolff Effects of Long Term Antibiotic Therapy on Exacerbation Rate in Stable COPD 8861 Imperial College of Science, Technology and Medici Dr John Hurst Patients (WP3) 8863 Cardiac ATTR prevalence study UCL Dr Julian Gillmore 8864 309: XL184 vs placebo in subjects with hepatocellular carcinoma Exelixis, Inc. Professor Tim Meyer 8875 Novel Coronavirus Observational Study University of Oxford Michael Jacobs 8878 TheraSphere® vs soc Sorafenib in Hepatocellular Carcinoma with PVT Nordion (Canada) Inc. Professor Tim Meyer 8884 156-12-203:Phase I Tolvaptan in subjects with SIADH (Hormone) Otsuka Pharmaceutical Development & Commercializat Professor Pierre-Marc Gilles Bouloux 8891 MDex vs BMDex in systemic lightchain (AL) amyloidosis European Myeloma Network Dr Ashutosh Wechalekar 8892 Targeted retreatment of COPD exacerbations (WP4) Imperial College of Science, Technology and Medici Dr John Hurst 8899 Mascot v12 UCL Dr Mallika Sekhar 8902 Genetics of Obesity Study (GOOS) Wellcome Trust Dr Sangeeta Chopada 8912 FOCUS4: Molecular selection of therapy in colorectal cancer Medical Research Council Dr Astrid Mayer 8913 ABC06: ASC alone or with mFOLFOX for advanced biliary tract cancer The Christie NHS Foundation Trust Dr Roopinder Gilmore 8916 The adaptive immune response in Hepatitis B vaccination UCL Dr Dianne Irish 8917 PATHSEEK UCL Dr Tanzina Haque

8919 Effect of intensive endocrine input on time for correction of hyponatraemia in SIADH UCL Dr Ploutarchos Tzoulis

8921 Understanding kidney disease in scleroderma Royal Free London NHS Foundation Trust Professor Chris Denton 8922 Continuation Study of Prophylactic BAX 855 in PTP with Haemophilia A Baxter Innovations GmbH Dr Pratima Chowdary 8928 Awareness of Illness Following Brain Damage Kings College London Dr Charlie Davie 8929 Phase III Study in Metastatic Castration Resistant Prostate Cancer SOTIO a.s Dr Maria Vilarino-Varela 8930 ELAD for Treatment of AILD (VTI208) Vital Therapies Inc Professor Rajiv Jalan 8932 MANTA Queen Mary University of London Dr Jacqueline Newby LGX818, MEK162 and LGX818 vs vemurafenib in melanoma patients 8933 Novartis Pharma Services AG Dr Amna Sheri (COLUMBUS) 8934 Magnetic Resonance Imaging of Lung Nodules UCLH Research Governance Unit Dr John Hurst 8942 SPIRO-CKD University of Birmingham Dr David Wheeler 8943 Isolation of blood-derived progenitor cells Papworth Hospital NHS Foundation Trust Dr Gerry J Coghlan 8944 CV risk in HIV patients switching from a boosted PI to DTG St. Stephen's AIDS Trust Professor Margaret A Johnson 8948 The Hepatitis C Treatment Journey London School of Hygiene & Tropical Medicine Professor William Rosenberg 8957 PROMPTS Institute of Cancer Research Dr Maria Vilarino-Varela 8963 Care of Late Stage Parkinsonism (CLaSP) UCL Dr Anette Schrag Royal Free London NHS Foundation Trust Open Studies

R&D No Short Title Sponsor Organisation Principal Investigator

8973 The role of Gastroesophageal Reflux in Scleroderma Pulmonary Fibrosis Royal Brompton and Harefield NHS Foundation Trust Professor Chris Denton

8975 REVascularisation for Ischaemic Ventricular Dysfunction (REVIVED) Kings College London Dr Tim Lockie 8980 Calcineurin resistant EBV specific T cells for Solid Organ Transplant Great Ormond Street Hospital Children NHS Trust Dr Mark Harber 8982 ICECAP-O Kings College London Dr Aine Burns 8983 NIHR BioResource - Rare Diseases Cambridge University Hospitals NHS Foundation Trus Dr Gerry J Coghlan 8985 RITUXILUP, Version 1.0 Imperial College London Prof Alan Salama 8991 ELAD for Treatment of AAH - VTI 210 Vital Therapies Inc Professor Rajiv Jalan 9003 Explanted livers for decellularisation and tissue characterisation UCL Dr Kurinchi Gurusamy

9008 CONCYST:Needle based confocal laser endomicroscopy of pancreatic cysts UCL Prof Stephen P Pereira

9012 A double-blind study using Canakinumab in Hereditary Periodic Fevers Novartis Pharmaceuticals Dr. Helen J. Lachmann

9014 ECU-NMO-301 Phase3 study:Eculizumab for Relapsing Neuromyelitis Optica Alexion Pharmaceuticals, Inc. Dr Desmond Kidd

9015 ECU-NMO-302 Phase 3 Open-Label Extension Study of Eculizumab for NMO Alexion Pharmaceuticals, Inc. Dr Desmond Kidd

9020 Radiocyst 01 UCL Prof Stephen P Pereira 9030 Working Memory Training in Type 2 Diabetes Middlesex University Miranda Rosenthal 9038 The HALT-LTBI Study UCL Dr Marc Lipman 9040 Evaluation of [18F]FETßAGTOCA Imperial College London Professor Martyn Caplin 9041 Host & Viral factors associated with HIV1 UCLH Dr Sabine Kinloch-de-Loes 9043 PDOPPS Arbor Research Collaborative for Health Dr Andrew Davenport 9044 CBT vs Standardised Medical Care to treat Dissociative Seizures Kings College London Dr Heather Angus-Leppan 9046 STOP-ACEi Hull & East Yorkshire Hospitals NHS Trust Dr Ashlin O'Riordan 9048 RCT of Normothermic Perfusion Vs Cold Storage in Liver Transplant v1 University of Oxford Mr Charles Imber 9050 ESPAC5F: European Study Group for Pancreatic Cancer Trial University of Liverpool Professor Brian R Davidson 9051 BILAG Biologics Prospective Cohort The University of Manchester Dr Voon Hong Ong 9056 PAlliative Care in chronic Kidney diSease study (PACKS study) Queens University belfast Dr Aine Burns 9059 The Scleroderma Patient Centered Intervention Network (SPIN) Cohort Royal Free London NHS Foundation Trust Professor Chris Denton 9061 EPOCH Trial Queen Mary University of London Mr Rovan D'souza 9065 Acute Respiratory Tract Illness in an HIV infected population University College London Dr Marc Lipman 9068 SEND Queen Mary University of London Dr Janavikulam Thiruchel; Dr Wayne Halfpenny 9072 Hyperthermia for Intermediate risk bladder cancer (HIVEC-II) Queen Mary University of London Mr Vibhash Mishra 9074 The impact of robotic sugery on teamwork University of Leeds Dr Daren Francis (LC) 9076 Head and Neck 5000 NHS Bristol Mr Janavikulam Thiruchelvum 9077 BSRBR-AS University of Aberdeen Dr Jeffrey Lee 9080 Streamline L CR UK & UCL Cancer Trials Centre Dr Sajid Khan 9086 Timely UCL Tanya Ahmad 9087 UKALL 2011 University of Birmingham Dr Lynn Riley 9088 OPTIMA UCL Dr Peter Ostler; Jackie Newby 9089 Depression and physical activity in people with multiple sclerosis Royal Holloway, University of London DR Conor O Malley 9090 Clinical Relevance Of Microbleeds In Stroke (CROMIS-2) UCL Dr Daniel Epstein 9091 RIAltO version 2 University of Liverpool Dr Andres Virchis 9092 SMART Barts and the London Mr Pawan Mathur 9093 ETHOS University of Aberdeen Mr Pawan Mathur 9096 Evaluating the Age Extension of the NHS Breast Screening Programme University of Oxford Dr William Teh 9097 PIC Genetics of Human Epilepsy King;s College London Jacqueline Taylor Royal Free London NHS Foundation Trust Open Studies

R&D No Short Title Sponsor Organisation Principal Investigator

9098 An Epidemiological ASD Study and Establishing a Research Database v1.0 Newcastle Univeresity Dr Lara Shaffer

9099 ICISS Royal United Hospital Bath NHS Trust Dr Dulmini Birkett 9100 United Kingdom Paediatric Chronic ITP Registry Central Manchester and Manchester children's Unive Dr Ian Pollock 9106 ORANGE II PLUS University Hospital Maastricht Dr Guiseppe Fusai 9108 1089- Phase 3 double-blind study of F/TAF in HIV-1 positive patients Gilead Sciences, Inc. Professor Margaret A Johnson 9111 SPOT Trial v 1.0 (13th June 2013) Queen Mary University of London Dr Ferina Ismail A Phase III Open Label, Multicenter, Extension Study to Assess the Safety and 9117 CSL Behring AG Dr Pratima Chowdary Efficacy of Recombinan 9118 BOXIT- Bladder COX-2 Inhibition Trial (2074 CLRN Ref) Cambridge University Hospitals Foundation Trust Colin Bunce 9119 NEO-EXCEL University of Birmingham Dr Rob Stein 9124 Utility F. Hoffmann La Roche Ltd Dr Ameet Bakhai 9128 STETH Barnet & Chase Farm Hospitals NHS Trust Dr Ameet Bakhai 9129 CANTOS Novartis Consumer Healthcare Dr Ameet Bakhai 9132 The Parkinson's Pain Study Salford Royal NHS Foundation Trust Professor Huw Morris 9133 Zibotentan better renal scleroderma outcome study (ZEBRA) UCL Professor Chris Denton 9135 Human papillomavirus in lacrimal papillomas & carcinomas UCL Dr Daniel Webster 9137 Image guidance with image overlay for laparoscopic surgery UCL Professor Brian Davidson 9138 Phase 2 Study of Fostamatinib for Subjects with IgA Nephropathy Rigel Pharmaceuticals Inc Dr Daniel Gale 9139 OAK F Hoffmann-La Roche Ltd Dr Hemal Ariyaratne 9147 SNIFFLE 2 Study University Hospital Southampton NHS Foundation Tru Dr James Gardiner 9148 28431754DNE3001: The CREDENCE Trial Janssen-Cilag International N.V. Dr David Wheeler 9150 Chemotherapy induced cognitive changes in colorectal cancer patients City University London Dr Astrid Mayer 9154 Sequencing Based Analysis of SLE King's College London Dr Richard Stratton

9155 HERALD-1: HEpatic Resection Analgesia and Length of time to Discharge UCL Dr Ciara Donohue

9157 DILSTENT2 University College London Prof Stephen P Pereira 9159 CtG Huddle (S.A.F.E) UCL Dr Rahul Chodhari 9164 ECLIPSE: Exploring the Current Landscape of IV Infusion Practices v.1 Joint UCLH/UCL Biomedical Research (R&D) Unit Dr Astrid Mayer 9165 EMMACE4 University of Leeds Dr Gerry J Coghlan 9167 METI MRI evaluation of tracheal inflammation in GPA UCL Dr Mark Little 9168 Clinical salt and water monitoring with dielectric spectroscopy Royal Free London NHS Foundation Trust Dr Stephen B Walsh 9170 V2 Receptors in ADPKD kidneys Royal Free London NHS Foundation Trust Prof Patricia Wilson 9174 ROLARR (RObotic versus LAparoscopic Resection for Rectal cancer) University of Leeds Dr David Jayne 9177 PLORAS version 1 UCL Dr Daniel Epstein 9179 The immunological basis of preterm delivery Imperial College of Science, Technology and Medicine Rimi Shah 9182 MAMMO-50 version 1.0 University of Warwick Dr Glenda Kaplan; Dr. Shramana Banerjee 9190 New markers autoimmune liver disease Royal Free London NHS Foundation Trust Dr Douglas Thorburn 9196 TIGRIS AstraZeneca UK Limited Dr Ameet Bakhai

9197 Supply of Tissue to Donate for Research Initiative from the Royal Free Hospital DRI Initiative

9201 DREAM Study (Daily Remote Ischaemic Conditioning following AMI) University of Leicester Dr Gerry J Coghlan 9202 BASIL-2. Version 1.0 University of Birmingham Mr Lim Chung Reformulated raltegravir q.d. (1200 mg) versus raltegravir b.i.d. (400 mg) in ART- 9211 Merck Sharp & Dohme Corp., a subsidiary of Merck & Professor Margaret A Johnson naïve pts 9213 E7080-G000-304 - Unresectable Hepatocellular Carcinoma (REFLECT) Eisai Ltd Professor Tim Meyer 9217 Patient reported outcomes in prostate cancer radiotherapy version 1.1 The Institute of Cancer Research Dr Maria Vilarino-Varela 9219 STAR: Standard vs Modified Drug Therapy in Renal Cancer University of Leeds Dr Katia Boleti Royal Free London NHS Foundation Trust Open Studies

R&D No Short Title Sponsor Organisation Principal Investigator 9220 REstart or STop Antithrombotics Randomised Trial (RESTART) ACCORD Dr Rustam Al-Shahi Salman 9221 Assessing the course of recovery following ischaemic stroke. ReNeuron Ltd. Miss Caroline Watchurst 9222 Secondary Screening for Early Pancreatic Cancer in HP University Of Liverpool Prof Stephen P Pereira 9223 RTL Advanced Study NHS Greater Glasgow and Clyde Dr Astrid Mayer 9231 InfeCtion respONse through vIrus genomiCs (ICONIC) UCL Dr Tanzina Haque 9234 TRACERx UCL Dr Katia Boleti; Dr Girija Anand 9240 PALLET Royal Marsden NHS Foundation Trust Dr Peter Ostler 9241 68Ga-DOTATOC in patients with GEP-NETs. Advanced Accelerator Applications SA Dr. Shaunak Navalkissoor 9244 Evaluation of the sensitivity of the Quantiferon Gold Plus assay Royal Free London NHS Foundation Trust Dr James Brown 9245 Gaucherite stratified medicine project Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge Dr Derralynn Hughes

9246 Rituximab versus cyclophosphamide in connective tissue disease-ILD (RECITAL) Royal Brompton and Harefield NHS Foundation Trust Professor Chris Denton

9252 PANasta University of Liverpool Professor Brian R Davidson 9254 UNIRAD V5.0 14/02/2014 UNICANCER Dr Jacqueline Newby 9257 (duplicate) RTL Peri-operative Study (original IRAS project 29926) NHS Greater Glasgow and Clyde Dr Astrid Meyer 9264 SAP115970: GSK2398852 followup GSK Clinical Pharmacology Science and Study Operate Thirusha Lane 9265 Characterisation of genetic skin conditions Kings College London Dr Ioulios Palamaras 9267 CULPRITSHOCK University of Leipzig Dr Tim Lockie 9272 HIV Once Daily ARV Single Tablet bPI Regimen (EMERALD) Janssen Research and Development Prof Margaret Johnson ASSET phase II study to evaluate subcutaneous abatacept vs. placebo in diffuse 9273 University of Michigan Professor Chris Denton cutaneous systemic 9276 Pilot study investigating pressures exerted on amputees remaining limb Royal Free London NHS Foundation Trust Mr Richard Leigh 9278 RIVER - Research In Viral Eradication of HIV Reservoirs Imperial College London Prof Margaret Johnson 9279 Brain in Pain III (CFS) QMUL Dr Julius Bourke 9280 Work and Health Study Royal Free London NHS Foundation Trust 9282 Monitoring reconstructed ears and noses UCL Prof Peter Butler 9283 Health related quality of life in non-alcoholic fatty liver disease Royal Free London NHS Foundation Trust Dr Emmanouil Tsochatzis 9287 PARAMEDIC 2: The Adrenaline Trial University of Warwick Jonathan Costello

9289 Screening for depression in South Asians with End Stage Renal Disease East and North Hertfordshire NHS Trust Dr Andrew Davenport

9291 Analysis of specimens from patients with painful metal on metal hips replacements. Royal National Orthopaedic Hospital NHS Trust Dr Simon Warren

9292 SOBI.ANAKIN-201 study Swedish Orphan Biovitrum AB Dr. Helen J. Lachmann 9294 Riociguat in diffuse cutaneous systemic sclerosis (dcSSc) Bayer Public Limited Company Professor Chris Denton

9297 TOPAZ I- study in ABT-450/Ritonavir/ABT-267 and ABT-333 in chronic HCV University of Oxford Professor William Rosenberg

9301 COMPARE University of Oxford Dr Neil Banga

9303 InterAACT A Multicentre Randomised Phase II Advanced Anal Cancer Trial Royal Marsden NHS Foundation Trust Dr Astrid Mayer

9305 Dry January - Healthy Volunteers 1 month Alcohol Abstention Royal Free London NHS Foundation Trust Professor Kevin Moore; Dr Amir Gander 9308 TheraSphere in Unresectable Hepatocellular Carcinoma (HCC) TS-103 Biocompatibles UK Ltd Professor Tim Meyer 9310 Avoidable Mortality from In-hospital Cardiac Arrest London School of Hygiene and Tropical Medicine Sarah Stanley 9312 Improving the detection of active TB in A&E departments (ACE Study) Public Health England Dr Marc Lipman 9313 Measurement of Exercise Tolerance for Surgery (METS) Study Queen Mary University of London Dr Daniel Martin 9317 Pilot Study for validation of the MDS-NMS Rater-Administered Scale King's College London Dr Anette Schrag 9319 Cardamon trial University College London Dr Andres Virchis 9323 European Peripartum Cardiomyopathy Registry National Waiting Times Centre Board Dr Ameet Bakhai 9324 Seroprevalence survey of BBV in Emergency Departments attendees Public Health England Dr Alison Rodger Royal Free London NHS Foundation Trust Open Studies

R&D No Short Title Sponsor Organisation Principal Investigator 9327 CEDAR Queen Mary University of London Dr Katia Boleti 9330 Mechanisms of Intestinal Fibrosis in Crohn's Disease UCL Professor Massimo Pinzani 9331 A Long Term Follow-up Study of Subjects previously treated with MK5172 Merck Sharp & Dohme Corp Dr Tabinda Burney 9334 Pilot Study of FFP104 Dose Escalation in PBC Subjects (HEPA 3858) Fast Forward Pharmaceuticals, B.V. Dr Douglas Thorburn 9335 15613211:OpenLabel Trial to Evaluate Long Term Safety of Tolvaptan. Otsuka Pharmaceutical Development & Commercializat Dr Daniel Gale 9337 Sclero XIII UCL Professor Chris Denton 9339 Parkinson's Families Project (PFP) UCL Professor Huw Morris 9340 Phase 3 study in treatment-naïve HIV-1 infected subjects Merck Sharp & Dohme Corp., a subsidiary of Merck & Professor Margaret A Johnson 9348 Secondary Screening in Familial Pancreatic Cancer Royal Liverpool University Hospitals NHS Trust Prof Stephen P Pereira 9352 Ethnic variability in nerve conduction studies (Student Study) v.1 UCL Dr Marsha Y Morgan 9355 PLATFORM Royal Marsden NHS Foundation Trust Dr Astrid Mayer 9361 Albumin To prevenT Infection in chronic liveR failurE (ATTIRE) University College London Professor Rajiv Jalan 9362 Phase 1 of Nivolumab in Advanced HCC Bristol-Myers Squibb Tim Meyer 9364 Extending Working Lives in the NHS version 1 University of Leicester Yemisi Oluyede 9367 Urodynamic assessment methods before Prostate Surgery North Bristol NHS Trust Mr Vibhash Mishra

9375 Monoprost® compared with Lumigan® in POA glaucoma/ocular hypertension Laboratoires THÉA Mr Vikas Sharma

9378 Physical Activity Questionnaire for CKD East and North Hertfordshire NHS Trust Dr Andrew Davenport 9381 SPLDv3 IMS Health Mr TF Chan 9384 Stratification of antimicrobial treatment for TB by WGS UCL Dr Marc Lipman 9387 MelMarT - Melanoma Margins Trial - Pilot Study Australia and New Zealand Melanoma Trials Group Mr Stephen Hamilton 9395 After the Liverpool Care Pathway University of London EXT Caroline Hockett 9401 Alnylam ALN-TTR02-004 - TTR Mediated Polyneuropathy (FAP) Alnylam Pharmaceuticals, Inc Dr Julian Gillmore 9402 The UK-AIH Cohort The Newcastle upon Tyne Hospitals NHS Foundation Trust Dr Douglas Thorburn 9405 Ext Study AT1001-042 Effects of AT1001 in Patients with Fabry Disease Amicus Therapeutics Inc. Dr Derralynn Hughes

9409 REPAIR-Right vEntricular remodeling in Pulmonary ArterIal hypeRtension Actelion pharmaceuticals Ltd Dr Gerry J Coghlan

9415 SCALOP-2 V2.04Feb2015 University of Oxford Dr Roopinder Gillmore 9418 Plegridy Real World Observational Program (POP) Biogen Idec Research Limited Dr Heather Wilson 9419 Next Generation Tests for Latent Tuberculosis Infection University College London Dr Marc Lipman 9420 Exploring the Experience of HIV Positive Patients Treated for Cancer University College London 9421 Communicating Genetic Research in Complex Neurological Diseases Royal Free London NHS Foundation Trust Miss Concetta Brugaletta 9430 PORTICO Actelion Pharmaceuticals Ltd. Dr Gerry J Coghlan 9431 Validation of laser speckle contrast imaging and thermography in SSc University of Manchester Christopher Denton 9432 PRECISION University College London Mr Paras Singh 9433 EVERREST: Developing a therapy for Fetal Growth Restriction University College London EXT Alison Wright 9436 Airway Management in cardiac arrest patients (AIRWAYS-2) South Western Ambulance Service NHS Veronica Conteh 9437 MORQUIO A REGISTRY STUDY(MARS) BioMarin Pharmaceutical Inc London Dr Derralynn Hughes 9439 GEM Project University of Edinburgh Dr Charles Murray 9443 Characterising the prodrome of Gaucher's associated Parkinson's Medical Research Council (MRC) Professor Anthony HV Schapira 9444 Comparison of MRI with Colonoscopy for CGD-associated colitis Royal Free London NHS Foundation Trust Dr David Lowe 9445 Decision-making in the management of recurrent tonsillitis University College London Hospital Mr Alam Hannan

9448 WO29637. A Study of anti PD-L1 Antibody in Renal Cell Carcinoma (RCC) F Hoffmann-La Roche Ltd Prof Thomas Powles

9453 Pilot study to determine the effect of dialysis on intestinal biome UCL joint research office Dr Andrew Davenport 9457 PSP CBD MSA Longitudinal Study UK (PROSPECTMUK) University College London Professor Huw Morris 9459 FTC/RPV/TAF switch from FTC/RPV/TDF in HIV-1 positive Gilead Sciences Europe Ltd Professor Margaret A Johnson Royal Free London NHS Foundation Trust Open Studies

R&D No Short Title Sponsor Organisation Principal Investigator 9460 IRISS (ILUVIEN Registry Safety Study) Alimera Sciences Limited Mr Riaz Asaria 9461 MUK Eight University of Leeds Professor Atul B Mehta 9462 Safety and effects of FP-02.2 - first doses in humans;v1 Vaxin UK Ltd Professor William Rosenberg 9463 Acceptability of alternate-day in-centre haemodialysis: an evaluation East and North Hertfordshire NHS Trust Dr Andrew Davenport 9464 Questionnaire review of Anderson-Fabry gastrointestinal symptoms Royal Free London NHS Foundation Trust Dr Derralynn Hughes 9466 Liver Immunosuppression Free Trial ("LIFT"), version 1 Kings College London Dr Aileen Marshall 9467 Psoriasis - A Life Story Royal Free London NHS Foundation Trust Dr Sandy McBride 9469 Radium-223 in subjects with bone predominant metastatic CRPC. Bayer HealthCare AG Dr Maria Vilarino-Varela The effect of branch stent choice on branch-related outcomes in complex aortic 9471 Royal Free London NHS Foundation Trust Miss Tara Mastracci repair 9472 Add-Aspirin Medical Research Council (MRC) Dr Astrid Meyer 9477 MK-1439A versus ATRIPLA in treatment-naïve HIV-1 infected subjects Merck Sharp & Dohme Corp., a subsidiary of Merck & Professor Margaret A Johnson 9480 STOP-HCV Cirrhosis Study Nottingham University Hospitals NHS Trust Professor William Rosenberg 9481 Haemophilic Arthropathy and the role of Extracellular Histones-V1 University of Liverpool Dr Pratima Chowdary 9483 Phase 1, FIM study of BAY 1093884 in Subjects with Heamophilia A or B Bayer AG Dr Pratima Chowdary 9484 LORIS, Version 1.0 14th February 2014 University of Birmingham Dr Teh Williams 9486 LV gene therapy for CGD Genethon Dr Emma C Morris 9487 EAST: Early treatment of AF for Stroke prevention Trial: 10-May-2013 AFNET e.V. [German Atrial Fibrillation Competence Dr Ameet Bakhai 9488 Multiple myeloma lifestyle study UCL Professor Atul B Mehta 9489 REMINET Fédération Francophone de Cancérologie Digestive ( Dr Christos Toumpanakis 9490 DARWIN1 UCL Dr Girija Anand 9491 SPEAK: Surveying People Experiencing young Adult Kidney failure University of Bristol EXT Eugenia Papakrivopoulou Switch to MK-1439A from Ritonavir-boosted Protease Inhibitor regimen in HIV-1 9492 Merck Sharp & Dohme Corp., a subsidiary of Merck & Professor Margaret A Johnson infected subjects 9493 1717 - Phase 3b switch study with F/TAF in HIV-1 infected subjects Gilead Sciences, Inc. Professor Margaret A Johnson 9494 RIVER Registry – RIVaroxaban Evaluation in Real life setting Thrombosis Research Institute Dr Ameet Bakhai 9495 International CTEPH Registry International CTEPH Association Dr Gerry J Coghlan 9498 Cardiac Output optimisation following Liver Transplantation (COLT) Tri UCL Professor Brian Davidson 9499 G-TOG - Gentamicin in the Treatment of Gonorrhoea University Hospitals Birmingham NHS Foundation Tru Dr Daniel Ivens 9503 Brain network structures in Idiopathic Generalised Epilepsy (IGE) King's College London Dr Heather Angus-Leppan 9507 VOYAGER PAD Bayer HealthCare AG Miss Janice Tsui 9508 FI intervention study (FINS) North West London Hospitals NHS Trust Kay greveson 9510 Understanding the nature of inhibitors in haemophilia University College London Professor Amit Nathwani 9512 POPPY Pharmacokinetic and clinical observations in people over fifty Imperial College London Professor Margaret A Johnson 9514 BAYER 17845 Phase 1 dose escalation study of BAY 1862864 Injection Bayer HealthCare AG Dr Christopher McNamara 9517 ETTAA Papworth Hospital NHS Foundation Trust Mr Jason Constantinou 9521 WA29767 - A study of Tocilizumab versus placebo in Systemic Sclerosis F Hoffman La Roche Limited Christopher Denton 9525 "OPTI-CLOT" goes United Kingdom (UK) Erasmus University Medical Center - Sophia Childre Dr Pratima Chowdary 9527 ACELARATE The Clatterbridge Cancer Centre NHS Foundation Tru Dr Roopinder Gilmore

9528 Switch Study of Dolutegravir + Rilpivirine in HIV infected adults -637 (SWORD2) Viiv Healthcare Professor Margaret A Johnson

9529 Pregabalin in subjects with Primary Generalised Tonic-Clonic seizures Pfizer Inc Dr Heather Angus-Leppan 9530 Investigating the microenvironment in SSc patients with severe sepsis UCL joint research office Dr Richard Stratton 9532 The ASTRIS Study Astra Zeneca Dr Hemal Ariyaratne 9533 Quantification and Piloting of ERAC (V1) University of Hertfordshire Dr Heather Angus-Leppan

9536 Abicipar Pegol in Neovascular age related macular degeneration (Sequoia) Allergan Ltd Mr Riaz Asaria; Hemal Mehta Royal Free London NHS Foundation Trust Open Studies

R&D No Short Title Sponsor Organisation Principal Investigator 9538 JVDE: The REACH-2 Study Eli Lilly and Company Professor Tim Meyer 9540 Supervisory ward sister/charge nurse survey University of Warwick 9541 TOPARP The Institute of Cancer Research Dr Maria Vilarino-Varela 9543 Native T1 Mapping in Rare Diseases University College London Dr Derralynn Hughes 9546 ABC-07 University College London Dr Roopinder Gilmore 9547 Protective TB University College London Dr Marc Lipman 9552 Monitoring heparin anticoagulation in major vascular surgery Royal Free London NHS Foundation Trust Dr Nick Schofield 9553 100,000 Genomes Project: Bioresource - main phase Protocol v1.0 Oxford University Hospitals NHS Trust Prof Robert Kleta; Dr Daniel Gale 9554 Open label ISIS 420915-CS3 Isis Pharmaceuticals, Inc. Dr Carol Whelan 9555 NEOD001 versus placebo in AL Amyloidosis (VITAL) Prothena Therapeutics Limited Dr Ashutosh Wechalekar 9558 PGE2 and immune suppression in decompensated cirrhosis University College London Dr. Alastair O'Brien 9561 OLE- Open Label Extension Regeneron Pharmaceuticals, Inc. Dr Mahreen Ameen 9563 PB102F03: Extension Study of PRX-102 in Fabry Disease Protalix Ltd Dr Derralynn Hughes 9570 Life after prostate cancer diagnosis Version 1 University of Leeds Miss Gillian Smith; EXT David Soloman 9572 OPTIMUM Trial Guy's and St Thomas' Foundation NHS Trust Dr James Goldring 9574 RCT of basic vs biofeedback-intensified PFMT for incontinence (OPAL) Glasgow Caledonian University Ms Amanda Holder 9575 ASCOT: Lifestyle study for cancer survivors UCL Jackie Newby; Dr Maria Vilarino-Varela 9577 ETNA-VTE-Europe Daiichi Sankyo Europe GmbH Dr Anja Drebes 9578 StOP Hamophilia A - Prdicted Trough Verses Measured Trough Royal Free London NHS Foundation Trust Dr Pratima Chowdary 9579 TRACER X Renal The Royal Marsden NHS Foundation Trust Mr Michael Aitchison 9581 A study of selumetinib in patients with Kaposi’s sarcoma (SCART) Sheffield Teaching Hospitals NHS Foundation Trust Dr Grant Stewart 9582 Targeted Radiotherapy for AL-Amyloidosis –‘TRALA’ University Hospital Southampton NHS Foundation Tru Dr Ashutosh Wechalekar 9583 Simvastatin as a neuroprotective treatment for moderate PD (PD STAT) Plymouth Hospitals NHS Trust Professor Huw Morris

9584 EMBARK:MDV3100-13 Phase3, Enzalutamide, nonmetastatic Prostate Cancer Medivation Inc Dr Maria Vilarino-Varela

9585 PAPERPAC UCL Prof Stephen P Pereira 9588 IMMUNET UCL Professor Tim Meyer 9590 PAVE trial v1.0 Guy's and St Thomas' Foundation NHS Trust Mr Colin Forman 9591 AlcoChange Royal Free London NHS Foundation Trust Professor Kevin Moore 9592 PCRF National Pancreatic Registry & Tissue Bank V1 Queen Mary University of London Professor Brian Davidson 9594 ETNA-AF-Europe - CARD 4754 DAIICHI SANKYO UK LTD Dr Ameet Bakhai 9602 Incidence of Malignancy in Patients with Lysosomal Storage Diseases Royal Free London NHS Foundation Trust Dr Derralynn Hughes 9603 UK-PK Study Hampshire Hospitals NHS Foundation Trust Dr Pratima Chowdary 9607 Non-alcoholic Fatty Liver Disease in Primary Care: Patient Attitudes UCL Dr Ankur Srivastava

9609 PEDAL: Long-term Outcome of Children Enrolled in Study ROPP-2008-01 Premacure AB, A member of the Shire Group of Compa Mr Saurabh Jain

9611 FILTR Study Field St George's University of London Deborah Williams

9612 M13-549 Phase 3 JAK study csDMARD subjects with Moderate to Severe RA AbbVie Ltd Dr Voon Hong Ong

9613 New Biomarkers of Early Myocardial Infarction Kings College London EXT Timothy Lockie 9614 PROSPER - Hepatic Encephalopathy Observational Study ZZ2014GL03 Norgine Ltd Professor Raj Mookerjee 9616 Muscle connective tissue in limb development and disease King's College London Mr Bran Sivakumar 9617 NEOBLADE Version: 2 Clatterbridge Centre for Oncology NHS Trust Dr Maria Vilarino-Varela

9618 Investigation into the Natural Topography of Human Arterial and Venous Tissue UCL Dr Amir Gander; Professor Massimo Pinzani

9620 Phase 4 study of Voncento in Subjects with Von Willebrand Disease CSL Behring GmbH Dr Pratima Chowdary 9621 1199.214 Nintedanib vs placebo in scleroderma related lung fibrosis Boehringer Ingelheim Limited Professor Chris Denton Royal Free London NHS Foundation Trust Open Studies

R&D No Short Title Sponsor Organisation Principal Investigator 9622 CLARINET FORTE Final Version: 19 May 2015 Ipsen Innovation Dr Christos Toumpanakis 9623 A randomised study of high flow nasal cannula therapy in bronchiolitis Great Ormond Street Hospital NHS Foundation Trust Dr Kin Man 9625 ECHO: Expanding Communications on Hemophilia-A Outcomes Bayer Dr Pratima Chowdary 9629 STOP-HCV-1 version 3.0 Imperial College London Dr Sanjay Bhagani 9633 Phase 2 Open Label MGCD265 in patients with NSCLC Mirati Therapeutics, Inc Dr Katia Boleti 9634 IVA337 SSc POC Inventiva SAS Christopher Denton

9636 RaDaR: The National Study of Nephrotic Syndrome (NephroS) NURTuRE-NS University of Bristol Dr David Wheeler

9640 An open label study of Tocilizumab in PAH Papworth Hospital NHS Foundation Trust Dr Gerry J Coghlan 9642 LAVA-Liver resection surgery versus thermal ablation for CLM UCL Professor Brian Davidson 9643 Multipart, double blind study to assess safety, tolerability and effi Novartis Pharmaceuticals UK Ltd Dr Douglas Thorburn 9647 Phase III prostate cancer trial: surgery, radiotherapy, stereotactic (PACE) Royal Marsden NHS Foundation Trust Dr Maria Vilarino-Varela 9650 The PRIME Study: Positive tRansItions through the MEnopause University College London Dr Fiona M Burns 9651 Phase 3 study with GS-9883/F/TAF in HIV-1, treatment naïve subjects Gilead Sciences, Inc. Professor Margaret A Johnson 9652 ERIC-PPCI UCLH Dr Roby Rakhit 9653 Phase 1 BAX 826 Dose-Escalation Safety Study, Protocol 291501 Baxalta Innovations GmbH Dr Pratima Chowdary 9656 Boiled Oral Peanut Immunotherapy (The BOPI Study) Imperial College London 9657 GS-9883/F/TAF versus ABC/DTG/3TC in HIV-1, treatment-naive subjects Gilead Sciences Inc. Professor Margaret A Johnson 9659 Validation of Macimorelin as Test for Adult Growth Hormone Deficiency Aeterna Zentaris GmbH Dr Bernard Khoo 9660 PCYC-1137-CA Pharmacyclics LLC Dr Roopinder Gillmore 9663 Vascular Changes in CKD Royal Free London NHS Foundation Trust Dr Benjamin Caplin 9664 Vision in Parkinson's Disease UCL Dr Rimona Weil 9665 MK1439A in treatment naïve HIV1 infected subjects with NNRTI transmitt Queen Mary University of London Professor Margaret A Johnson 9666 Switch HIV infected subjects with CNS toxicity from Atripla to MK1439A Merck Sharp & Dohme Corp Professor Margaret A Johnson 9669 Phase III study of Pembrolizumab in metastatic non-squamous NSCLC Merck Sharp & Dohme Corp., a subsidiary of Merck & Dr Hemal Ariyaratne 9670 Models of care for management of HIV in primary care. V1 University College London 9672 Measuring Severe Harm UCL EXT Hester Wain 9673 Experiencing the enhanced recovery pathway for caesarean section. Kings College London Mr David Conner 9675 Study of rare cutaneous lichenoid, alopecic and scarring variants King's College London Dr Ioulios Palamaras 9677 ACTICCA-1 University Medical Center Hamburg-Eppendorf Dr Roopinder Gillmore 9681 Characterising the biological markers of Renal cancer progression Royal Free London NHS Foundation Trust Miss Maxine Tran 9682 Important issues of research focus in children with ENT conditions. UCL Prof Monica Lakhanpaul 9687 Phase II ALNPCSSC placebocontrolled, doubleblind, cardiology trial The Medicines Company Dr Devaki Nair 9689 The Microcirculation in Liver Cirrhosis Royal Free London NHS Foundation Trust Dr Daniel Martin 9693 Validation of novel MR sequences in clinical practice GOSH Childrens' Charity Prof James Moon 9694 Fluoxetine Or Control Under Supervision (FOCUS) University of Edinburgh & NHS Lothian Dr Vivek Nadarajan 9697 Epilepsy in infancy (EPIPEG) Great Ormond Street Hospital NHS Foundation Trust EXT Juilet Pearce

9698 SHP-GCB-402-effect of Velaglucerase alfa on Bones in Gaucher Disease Shire Human Genetic Therapies, Inc Dr Derralynn Hughes

9700 Perspectives on functional disturbance following rectal cancer surgery Imperial College London 9701 Post HSCT Follow-up Royal Free London NHS Foundation Trust Dr Mari Campbell 9702 Breast PET feasibility study Royal Free London NHS Foundation Trust Dr Thomas Wagner 9704 Bone health in Haemophilia A & B Royal Free London NHS Foundation Trust Dr Pratima Chowdary 9708 Natural history and pathogenesis of systemic IgG4 disease Oxford University Dr Douglas Thorburn 9713 Topiramate Ocular Study (TOS) Royal Free London NHS Foundation Trust Ms Susanne Althauser; Hemal Mehta 9715 OuTSMART King's College London EXT Kin Yee Shiu Royal Free London NHS Foundation Trust Open Studies

R&D No Short Title Sponsor Organisation Principal Investigator 9716 RAMPP University of Oxford Dr James Goldring Profiling of serum HbsAg levels and Hepatitis B virus specific T-cells responses in 9717 Janssen R&D Dr Douglas Macdonald Chronic Hepatiti 9721 FLAIR version 1.0 University of Leeds Dr Parag Jasani 9722 261303 BAX 855 PK-guided Dosing Adults and Adolescents Baxalta Innovations GmbH Dr Pratima Chowdary 9726 SAMSON trial Imperial College London Dr Devaki Nair 9727 Tuning the immune response in TB version 1 UCL Dr Marc Lipman 9728 The UKPBC Nested Cohort Study (version 1) The Newcastle upon Tyne Hospitals NHS Foundation Trust Dr Douglas Thorburn 9729 Scleroderma Heart Study Royal Free London NHS Foundation Trust 9730 BESTT Women's Study Kings College London Professor Margaret A Johnson 9735 Exercise training in patients awaiting liver transplantation Royal Free London NHS Foundation Trust Dr Daniel Martin 9736 Pregabalin Open Label Follow up study of A0081105 Pfizer Inc Dr Heather Angus-Leppan 9737 CALYPSO Queen Mary University of London Dr Katia Boleti 9738 NEOD001 versus placebo in AL Amyloidosis with cardiac dysfunction Prothena Therapeutics Limited Dr Ashutosh Wechalekar Phase 1 Study of BLU-554 in Patients with Hepatocellular Carcinoma (CANC - 9742 Blueprint Medicines Corporation Professor Tim Meyer 4809) 9743 INTERACT: Therapist Survey and Delphi study University of Bristol 9744 ELAD for treatment of alcohol induced liver decompensation (VTL-308) Vital Therapies Inc Professor Rajiv Jalan 9746 Feasiblity study: RCT of Bracing of shoulder fractures (N-Brace Trial) Homerton University Hospital NHS Foundation trust Mr Philip Michael Ahrens 9749 Characterisation of Satellite Cells in Peripheral Artery Disease Royal Free London NHS Foundation Trust Miss Janice Tsui 9750 Gene Therapy for WAS follow-up, version 1.0 Genethon Dr Emma C Morris 9753 Trajectories of Outcome in Neurological Conditions V1 (TONIC) The Walton Centre NHS Foundation Trust EXT Richard Orrell 9756 Exercise training in patients awaiting complex aortic surgery Royal Free London NHS Foundation Trust Dr Daniel Martin 9758 DEFINE-FLOW University of Texas Medical School at Houston Dr Tim Lockie 9759 Safetxt: a randomised controlled trial of a safer sex intervention London School of Hygiene and Tropical Medicine Dr Daniel Ivens 9761 Retrospective PROMs London School of Hygiene and Tropical Medicine EXT Joyti Saksena 9764 The immunopathology of neurosarcoidosis The Royal Free Hospital Dr Malcolm Galloway 9767 ISCHEMIA V2.0 London (North West) Comprehensive Local Research Network Dr Paramjit Jeetley 9768 CA209-459 Nivolumab V Sorafenib in HCC Bristol Myers Squibb International Corporation Professor Tim Meyer 9769 High-Intensity Specialist-Led Acute Care (HiSLAC) project University of Birmingham Ext Rupert Negus 9771 Integrating palliative care into management of advanced liver disease University of Bristol Ms Lynda Greenslade 9774 GSK COPD GlaxoSmithKline PLC Dr John Hurst 9775 HPF burden of illness Observational patient diary study Novartis Pharma AG Dr. Helen J. Lachmann 9776 The BOSS Study University Of Liverpool Miss Olivia Malaga-Shaw Leading improvement: scoping the organisational determinants of clinical quality and 9777 University of Manchester Dr Mike Greenberg performance imp 9778 The REST Study Belfast Health & Social Care Trust Dr Daniel Martin 9779 Fabry Disease: Podocyturia, Non-Invasive Predictor of Renal disease Royal Free London NHS Foundation Trust Dr Uma Ramaswami 9780 CATALYST trial Joint UCLH/UCL Biomedical Research (R&D) Unit Dr Ashutosh Wechalekar 9782 UK - EHL Outcome Registry Royal Free London NHS Foundation Trust Dr Pratima Chowdary 9783 Point of Care lactate measurements Royal Free London NHS Foundation Trust Dr Anjly Jain 9784 Phase 3 open-label switch study with GS-9883/F/TAF in HIV-1 subjects Gilead Sciences, Inc. Professor Margaret A Johnson 9785 Optimizing Ovarian Tissue Transplantation UCL Mr Paul J Hardiman 9786 PARTNER Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge Dr Jacqueline Newby 9788 RESPECT-21: evaluation of specialist cancer surgery reorganisation UCL Prof Naomi Fulop 9790 Decision-making for intensive care unit admissions University Hospitals Coventry and Warwickshire Dr Nadine Flowers 9791 GP2017 and Humira in moderate to severe active rheumatoid arthritis Hexal, AG Dr Voon Hong Ong Royal Free London NHS Foundation Trust Open Studies

R&D No Short Title Sponsor Organisation Principal Investigator 9795 1177Lu-OPS201 phase I/II study for the therapy of NETs version 4.0 OctreoPharm Sciences GmbH Dr. Shaunak Navalkissoor 9797 PASIP MISP Royal Free London NHS Foundation Trust Dr David Chao 9800 Microparticles and MVD/LV impairment following STEMI UCL Dr Roby Rakhit 9802 POMP v0.1 (COPE-POMP trial) Oxford University Hospitals NHS Foundation Trust Dr Neil Banga 9803 M13-542 Phase 3 ABT-494 study in Mod/Severe RA with Bio-IR AbbVie Ltd Dr Voon Hong Ong

9806 Human bone tissue for study the performance of bone plugs (Explant Model) Royal National Orthopaedic Hospital NHS Trust Nimalan Maruthainar

9807 Early maladaptive schemas in diabetes and depression Middlesex University Miranda Rosenthal 9808 BAX 802 in Congenital Haemophilia A with Inhibitors Baxalta Innovations GmbH Dr Pratima Chowdary A Phase III, randomised, double-blind, multicentre, parallelgroup, non-inferiority 9809 ViiV Healthcare UK Limited Professor Margaret A Johnson study evaluating Exploring Patients with a Primary or Secondary Immunodeficiency Attitudes 9814 City University London Dr Mari Campbell Towards and Experiences of 9816 Non-invasive ventilator modems: a qualitative study Royal Free London NHS Foundation Trust Stephanie Mansell 9817 Domiciliary Monitoring to Predict Exacerbations of COPD University College London Dr John Hurst 9818 Ultrasound Location of Oscillating Shear Stress in Dialysis Fistulae UCL joint research office Mr Matthew J Bartlett 9819 RESOLVE-IT: A Study of Elafibranor in Patients with NASH and fibrosis Genfit Emmanuel Tsochatzis 9821 The dal-GenE trial DalCor Pharma UK Ltd Dr Ameet Bakhai 9822 M14-465 Phase 3 study in joint structure in Mod/Severe RA with MTX-IR AbbVie Ltd Dr Voon Hong Ong 9823 CANC 5717 Incyte Corporation Dr Amna Sheri 9824 COMET Genzyme Corporation Dr Derralynn Hughes 9827 A retrospective data analysis of therapy for neuroendocrine tumours Ipsen Pharma Dr Christos Toumpanakis CL04041023 - Clinical Rheumatoid Arthritis Development for Olokizumab (CREDO 9828 R-Pharm Dr Voon Hong Ong 2) 9829 Multi-Lead surface ECG Analysis of Inherited Cardiac Disease Joint UCLH/UCL Biomedical Research (R&D) Unit Dr Pier Lambiase 9831 Phase 3 study of Bardoxolone Methyl in patients with CTD-PAH Reata Pharmaceuticals, Inc Dr Gerry J Coghlan 9835 Physical Activity Opinions in Kidney Patients (QCKD) University Hospitals of Leicester Dr David Wheeler 9836 TRON (version 9.0) Cardiff University Dr Daniel Gale 9838 MIAA Validation Study - protocol version 1 Skin Analytics Dr Ioulios Palamaras

9841 BH30071 Prophylactic Emicizumab vs no Prophylaxis in Haemophilia A (HAVEN 3) F Hoffmann-La Roche Ltd Dr Pratima Chowdary

9844 LEAP Sanofi Dr Derralynn Hughes 9845 ACHILLES Novartis Pharma Dr Voon Hong Ong 9848 RELAY - Convergence Neuropathic Pain Study Covance CAPS Ltd Dr Heather Angus-Leppan 9850 STRIKE University of Leeds Professor Chris Denton 9853 REGENERATE Intercept Pharmaceuticals Inc Dr Emmanouil Tsochatzis 9856 PEARL Study / RESP 4602 Pearl Therapeutics, Inc. Dr John Hurst 9857 Platelet-rich plasma and fat graft for diabetic foot UCL Mr. Afshin Mosahebi 9858 Evaluation of AKI and Sepsis Breakthrough Series Collaborative UCL EXT Chris Laing 9859 The PHOTO Trial The Newcastle upon Tyne Hospitals NHS Foundation T Mr Paras Singh 9861 STRATUS ( SysTemic scleRosis AbiTUzumab Study ) Merck Pharmaceuticals Professor Chris Denton 9862 ACT14604 Sanofi recherche & developpement Professor Chris Denton 9864 First time in human study of oral antiserum Amyloid P (GSK3039294) GSK, Napp Pharmaceuticals and Chugai Pharma UK Ltd Thirusha Lane 9865 The use of excess tissue samples in biomedical research DRI Initiative 9866 Improving the management of drug resistant tuberculosis in the UK. UCL Dr Marc Lipman 9868 Evaluating the ten year impact of the Productive Ward King's College London 9869 ACQUIRE Study Otsuka Pharmaceutical Development & Commercializat Dr Daniel Gale 9870 Extension study of Patisiran in patients with FAP Alnylam Pharmaceuticals, Inc. Dr Julian Gillmore Royal Free London NHS Foundation Trust Open Studies

R&D No Short Title Sponsor Organisation Principal Investigator 9871 Target 3D University of New South wales (Australia) Dr Sanjay Bhagani 9874 Double blind study of Axitinib in progressive advanced G1-G2 NETs Grupo Español de Tumores Neuroendocrinos (GETNE) Dr Christina Thirlwell 9875 Kadcyla in combination with atezolizumab in 2L HER2+ mBC (KATE-2) F Hoffman La Roche Limited Dr Jacqueline Newby 9878 PRX-102 compared to Agalsidase Beta in Patients with Fabry Disease Quintiles Ltd Dr Derralynn Hughes

9880 Development of an EORTC QoL Module for Pancreatic NET: Phases 1-3 v1.0 Hampshire Hospitals NHS Foundation Trust Dr Dalvinder Mandair

9881 SPINET Ipsen Pharma Professor Martyn Caplin 9882 Alleviate1 Novo Nordisk A/S Dr Pratima Chowdary 9885 TB040: MVA85A aerosol vs IM in adults with latent M.tb infection University of Oxford Dr Marc Lipman 9887 REACT Study University Clinic Bonn Dr Sanjay Bhagani 9888 COMFFORT-Q University of Southampton Dr Ameet Bakhai 9889 TERRA Novartis Pharma Mr Riaz Asaria; Hemal Mehta 9890 C-Gall trial University of Aberdeen Professor Brian Davidson A study to define patient priorities and preferences when consentingto whole 9891 UCL Institute of Child Health Dr Daniel Gale genome sequencing to en 9894 Icatibant Outcome Survey (IOS). (Firazyr(R) Patient Registry) PPD Global Ltd Dr Suranjith Seneviratne 9896 UK FROST Trial South Tees Hospitals NHS Foundation Trust Mr Philip Michael Ahrens 9897 Identifying best composite prognosticators in fibrosing lung diseases Royal Brompton & Harefield NHS Foundation Trust Dr Joseph Jacob 9899 BEAT LUPUS UCL Prof Alan Salama 9900 MOCAM University of Southampton Davinder Sohal 9901 Cognitive Function & Type 2 Diabetes: A Study of Working Age Adults University of East London Miss Katy Lucas 9906 Predictors of self-management in patients with chronic low back pain The University of Nottingham Mr Adam Royffe 9907 NASH Quintiles Limited Dr Emmanouil Tsochatzis 9908 Investigating the impact of Implementing exercise on Haemodialysis St George's University of London Dr Ahmed Younis 9909 Thoracic MRI as a tool in diagnosis and follow up in CVID patients Royal Free London NHS Foundation Trust Dr Joseph Jacob 9911 Transcriptomic response to latent TB treatment London School of Hygiene and Tropical Medicine Dr Marc Lipman 9912 A Clinical Trial in subjects with active Ankylosing Spondylitis Novartis Pharma Dr Voon Hong Ong 9913 PANTHER Joint UCLH/UCL Biomedical Research (R&D) Unit Dr Astrid Mayer 9914 DIALIVE Yaqrit Limited Dr Daniel Martin 9915 Binocular Vision Study (BVMP) University of Oxford Hemal Mehta 9916 EXTEND Biogen Inc Dr Heather Angus-Leppan 9917 SAA1 as a CSF biomarker for neurosarcoidosis Royal Free London NHS Foundation Trust Dr Desmond Kidd 9918 AiM-PD UCL Professor Anthony HV Schapira 9919 Intraoperative Hypotension in Elder Patients (iHypE) UCL Dr Daniel Martin 9921 Causes of Acute Coronary Syndrome in People with SCAD or CAE University of Leicester Dr Roby Rakhit 9922 DETECT II UCL Mr Dimitrios Volanis Evaluating a novel prebiotic approach for the treatment of bacterial vaginosis 9923 Joint UCLH/UCL Biomedical Research (R&D) Unit Mr Paul J Hardiman inadvance of Clinical 9926 COBALT: Study of Obeticholic Acid in Primary Biliary Cirrhosis Intercept Pharmaceuticals Inc. Dr Douglas Thorburn Changes of Microbiome in Response to Treatment in Patients with Chronic Lung 9927 UCL Dr John Hurst Disease 9928 FAKTION Velindre NHS Trust Jackie Newby 9930 The BISTRO Trial Keele University Dr Andrew Davenport 9931 Open label Study with Maribavir and Investigator-Assigned Tx for CMV Shire ViroPharma Incorporated Dr Aileen Marshall; Dr Mark Harber 9932 Neurological Disease Severity Assessment The University of Manchester Dr Derralynn Hughes 9938 COSMOS: The metabolic response to major surgery The Royal Free Hospital Dr Daniel Martin

9940 Study of Intramuscular Cabotegravir + Rilpivirine in ART naive adults (FLAIR) Viiv Healthcare Professor Margaret A Johnson Royal Free London NHS Foundation Trust Open Studies

R&D No Short Title Sponsor Organisation Principal Investigator 9941 PIC MRI assessment of small bowel motility UCL Hospitals NHS Foundation Trust 9943 Perioperative Quality Improvement Programme: Patient Study UCL Dr Daniel Martin 9944 IRONMAN NHS Greater Glasgow & Clyde Dr Ameet Bakhai 9958 eULTIMASTER Terumo Europe N.V. Dr Sundeep Kalra 9960 CF-301 ContraFect Corporation Dr Daniel Martin 9964 Bayer Replace Bayer Dr Gerry J Coghlan 9965 Evaluation of Fat Grafting to treat Vulvar Lichen Sclerosus Joint UCLH/UCL Biomedical Research (R&D) Unit Prof Peter Butler

9966 Knowledge, attitudes and perceptions of 1. General practitioners 2. Junior doctors University of Sussex

9968 POETICS St George's Hospital Dr Daniel Martin 9972 Sobi.Elocta-002 _ A-SURE Swedish Orphan Biovitrum AB (SOBI) Dr Pratima Chowdary 9979 Gene therapy for Haemophilia A; version 1 UCL Dr Pratima Chowdary 9980 OPIP Guys and St Thomas NHS Trust Dr Swapna Mandal 9982 (PIC) Depletion of Serum Amyloid P Component in Alzheimer's Disease (v1.0). UCL Clinical Trials Unit Dr John Kennedy 9983 ROSCO University of Birmingham Dr Judy King 200808 Anaemia of CKD (non-dialysis): daprodustat vs darbepoetin alfa (RENA 9984 PPD Global Ltd Dr David Wheeler 4591) (ASCEND-ND) 9985 LuCID: Lung Cancer Indicator Detection Owlstone Veronica Conteh A Phase 2, Randomized, Double-Blind, Placebo Controlled Study Evaluating the 9987 Gilead Science Inc Dr Douglas Thorburn Safety, Tolerability, a 9988 Prevalence of ATTR amyloid in the carpal tunnel Royal Free London NHS Foundation Trust Professor Philip N Hawkins

9989 POM study of GSK2330811 in diffuse cutaneous systemic sclerosis 201247 GlaxoSmithKline PLC Professor Chris Denton A Phase 2, Randomized, Double-Blind, Placebo Controlled Study Evaluating the 9991 Gilead Sciences Inc Dr Douglas Thorburn Safety, Tolerability, a 9992 Efficacy and safety of iNO in Pulmonary Arterial Hypertension, v1.0 Bellerophon Pulse Technologies LLC Dr Gerry J Coghlan 9993 PRESSUREwire St Jude Medical Dr Tim Lockie 9994 Ward based goal-directed fluid therapy (GDFT) in acute pancreatitis The Royal Free Hospital Professor Brian R Davidson 9995 Predicting Acute-on-Chronic Liver Failure in Cirrhosis (PREDICT) EF CLIF Professor Raj Mookerjee 9996 Illness Perceptions In South Asian Haemodialysis Patients East and North Hertfordshire NHS Trust Dr Andrew Davenport 9997 Feasibility Study for Emergency Admissions PROMs London School of Hygiene and Tropical Medicine Ms Roxy Ribeiro 9999 Post static cold storage normothermic machine liver perfusion University of Oxford Mr Charles Imber 10003 Phase 2 - MBX-8025 in Participants with Primary Biliary Cholangitis CymaBay Therapeutics, Inc Dr Douglas Thorburn 10004 TOXYC: Targeted OXYgen therapy in Critical illness UCL Dr Daniel Martin 10005 Extend-3 v2.6 (19.4.16) Queen Mary University of London Dr Douglas Macdonald 10007 FANCONI-TAF (FANTA) study King's College Hospital NHS Foundation Trust Professor Margaret A Johnson 10008 SNAP-2 Epidemiology of Critical Care provision after Surgery (EpiCCS) University College London Dr Carlos Kidel; Dr Rajeev Jha; Dr Nicholas Hooker 10010 Positive Voices: National Survey of People with HIV Health Protection Agency (HPA) Dr Fiona Burns 10011 VERONA Biocompatibles UK Ltd Professor Tim Meyer Evaluation of safety following Immune Tolerance Induction treatment with turoctocog 10012 Novo Nordisk A/S Dr Pratima Chowdary alfa in patients 10013 PB-102-F30-Open Label Study of PRX-102 in patients with Fabry Disease Protalix Ltd Dr Derralynn Hughes

10014 RENA 5174 Alnylam Pharmaceuticals, Inc Dr Shabbir Moochhala ALXN1210 IN PATIENTS WITH ATYPICAL HEMOLYTIC UREMIC SYNDROME 10015 Alexion Pharmaceuticals Inc Dr Daniel Gale (aHUS) 10016 The BHF SENIOR-RITA TRIAL Newcastle upon Tyne Hospitals NHS Foundation Trust Dr Roby Rakhit 10018 Pulmonary Rehabilitation and Cardiovascular Risk in COPD UCL 10020 IBD Bioresource Addenbrookes' Hospital, Cambridge University Hospitals NHS Foundation Trust Dr Charles Murray Royal Free London NHS Foundation Trust Open Studies

R&D No Short Title Sponsor Organisation Principal Investigator 10022 QS-CMR Study Royal Free Hampstead NHS Trust Dr Tushar Kotecha 10023 Investigating patterns of influenza evolution in immunosuppression UCL Dr Marc Lipman 10024 Supporting family caregivers at end of life Royal Berkshire NHS Foundation Trust Ms Jo Wilson 10026 Co-existing skin cancers and chronic lymphocytic leukaemia Oxford University Hospitals NHS Foundation Trust Dr Ferina Ismail 10028 SUPERB Trial City University Dr Vivek Nadarajan 10029 INHALE WP1 UCL joint research office Dr Daniel Martin 10031 CARAT Sorin CRM SAS Dr Joseph Tomson 10032 Long term treatment with inclisiran and a comparison to evolocumab The Medicines Company UK Ltd Dr Devaki Nair 10033 PDR001 with dabrafenib + trametinib in BRAF+ve advanced Melanoma Novartis Pharma Dr David Chao 11034 ATLANTIS University of Glasgow Dr Maria Vilarino-Varela 11037 PrepareMe REGISTRY North Bristol NHS Trust 11038 QPL development in cirrhosis UCL Dr Douglas Thorburn 11039 Pancreatic Surgery pre- operative exercise programme UCL joint research office Dr Daniel Martin 11040 (PIC) ECUSTEC University of Birmingham 11041 Avacopan in patients with Vasculitis ChemoCentryx Prof Alan Salama 11042 FOLD Allergan Limited Mr Nobert V. Kang 11043 PRIMETIME The Institute for Cancer Research Dr Sarah Needleman 11046 ELF NHS Greater Glasgow and Clyde Dr Tanzeela Gala 11047 STRAP Barts Health NHS Trust Dr Richard Stratton 11049 NURTuRE-CKD The University of Nottingham Dr David Wheeler 11050 PRISM Queen Mary University of London Dr Carlos Kidel 11051 E7080-G000-307 (CLEAR) Eisai Ltd Prof Thomas Powles 11052 TEST-IT Study Belfast Health and Social Care Trust Dr Daniel Martin 10059 MND Register for England, Wales and Northern Ireland King's College London 10062 Biology of Juvenile Myoclonic Epilepsy King's College Hospital NHS Foundation Trust Dr Heather Angus-Leppan 10063 Effects of Vitabreath on exercise capacity and dyspnoea City University London Stephanie Mansell 10065 PDR001 in Neuroendocrine Tumours Novartis Pharma Dr Christina Thirlwell 10067 Brevera Study Hologic Dr William Teh

10068 IMmotion 010 WO39210 - Atezolizumab in patients with renal cell carcinoma Roche Products Limited Prof Thomas Powles

10069 201000 GLIMMER HEPA 31081 GSK Dr Douglas Thorburn 10070 EUROSTAD Sanofi Dr Mahreen Ameen 11072 177Lu-edotreotide vs. everolimus in GEP-NET – COMPETE ITM Solucin GmbH Dr. Shaunak Navalkissoor 11074 HAVEN. HCV/HIV PASS Study. Harvoni with TDF+PK enhancers. Gilead Sciences Inc Dr Sanjay Bhagani 11075 STELLAREX VASCULAR E-REGISTRY (SAVER) SPECTRANETICES Miss Janice Tsui 11076 Direct REporting of Awareness in MaternitY patients (DREAMY) St George's Hospital 11077 Diffusion Tensor Imaging of the myocardium Imperial College London Dr Mariana Fontana 11079 Post-operative HRQOL in Complex Aortic Vascular Patients using SMS Royal Free Hampstead NHS Trust Christine SATHANANTHAN 11080 Investigating the utility of qHBsAg in the management of CHB Barts and The London NHS Trust Professor William Rosenberg 11081 OPTIMISE II Queen Mary University of London Dr Daniel Martin 11083 Prepare for Kidney Care: RCT (PrepareME) North Bristol NHS Trust Dr Aine Burns 11084 ARIADNE Novartis Healthcare Pvt. Ltd. Dr Ameet Bakhai 11085 ASCEND-D GSK Pentraxin Therapeutics Ltd Dr Andrew Davenport 11086 HAPII impact and prevalence study University of Leeds Paul McLaughlin Study assessing long-term safety of bardoxolone methyl in PH patients (Reata 11087 Reata Pharmaceuticals, Inc Dr Gerry J Coghlan Ranger) Royal Free London NHS Foundation Trust Open Studies

R&D No Short Title Sponsor Organisation Principal Investigator 11090 Study to assess QCC374 in treatment of PAH Novartis Pharma Dr Gerry J Coghlan 11092 1245.121 EMPEROR-Reduced Study Boehringer Ingelheim Limited Dr Ameet Bakhai 11093 Phase III study with Finerenone in Type II Diabetes and DKD, Renal Bayer PLC Dr Dipesh Patel The Utility of Routine Pathology Results for Identifying Rare Diseases 11094 Burton Hospitals NHS Foundation Trust Dr Derralynn Hughes (PATHFINDER) 11095 Aurora (Stellaris) Tobira Therapeutics, a subsidiary of Allergan plc Dr Emmanouil Tsochatzis Host-pathogen interactions in meningococcal disease: Finding the key that fits the 11096 Public Health England (PHE) lock 11098 MYOPROSP The University of Manchester Dr Voon Hong Ong 11099 SysMedPD Joint UCLH/UCL Biomedical Research (R&D) Unit Prof Anthony Schapira 11100 PLUM Guy's and St. Thomas' NHS Foundation trust Dr. Helen J. Lachmann 11101 1245.110 EMPEROR-Preserved Study Boehringer Ingelheim Ltd Dr Ameet Bakhai 11102 BUTEO: A clinical trial of BTT1023 in patients with PSC The University of Birmingham Dr Douglas Thorburn 11103 FLO-ELA University Hospital Southampton NHS Foundation Tru Dr Suehana Rahman 11104 DEA-MVTI The Royal Free Hospital Agata Grasso 11106 Perfusion Mapping in Ischaemic Heart Disease and Cardiomyopathy UCL Dr Mariana Fontana 11107 CMV in Transplants University College London Hospitals NHS Foundation Trust (UCLH) Dr Mark Harber 11109 MA30143 - Ocrelizumab in patients with Multiple Sclerosis F Hoffman La Roche Dr Heather Wilson 11111 The NHS duty of candour – a step forwards? Imperial College London 11113 Phase 2b extension study to evaluate NEOD001 in Light Chain (AL) Prothena Therapeutics Limited Dr Ashutosh Wechalekar 11114 DUPI Sanofi Aventis Dr Mahreen Ameen 11117 DRAKO Non-interventional Study Bayer Mr Riaz Asaria 11118 ClarIDHy (AG-120) PPD Global Ltd Dr Roopinder Gillmore 11119 A Factor IX Gene Therapy Study (FIX-GT) UCL Dr Pratima Chowdary 11120 Biochemical markers of neuroendocrine tumours UCL Professor Martyn Caplin Image guidance with image overlay for robot assisted partial nephrectomy - A Pilot 11121 UCL Miss Maxine Tran study 11122 Care and prevent: skin infections and kidney disease London School of Hygiene & Tropical Medicine Dr Julian Gillmore 11123 The European Bronchiectasis Registry University of Dundee

11124 4255 - explorer™5 efficacy & safety of concizumab in Haem A no inhibitors Novo Nordisk Ltd Dr Pratima Chowdary

11127 M16-135, Glecaprevir/Pibrentasvir in HCV GTs 1,2,4,5,6 with Cirrhosis AbbeVie Professor William Rosenberg 11132 Do peripheral venous pressures reflect femoral venous pressure? Royal Free London NHS Foundation Trust Dr Jeremy Fabes 11133 The communication and exchange of social learning analysis Ulster University Mr Phillip Pledger; Mr TF Chan 11134 AFPc332T Cell Therapy in Advanced Hepatocellular Carcinoma (HCC) Adaptimmune LLC Tim Meyer 11154 EXCEED Novartis Pharmaceuticals UK Limited Dr Aminesh Singh

11174 Study PB-102-F50 PRX-102 in Fabry Disease Patients Treated with ERT (Protalix) Quintiles Dr Derralynn Hughes

11176 Phase 1b/2a Study of ABI-H0731 in Patients with Chronic Hepatitis B Assembly Biosciences Professor William Rosenberg NAC/Adj GEJ Adenocarcinoma with Chemo (XP/FP) vs Chemo + Pembro Study 11179 Merck Sharp & Dohme Ltd. (MSD) Dr Astrid Mayer KEYNOTE-585 11187 Donor gamete matching in fertility clinics University of Kent Building a culture of openness across the healthcare system: From transparency 11188 University of Leicester through learning to i 11189 The SIMPLIFIED Registry Trial Cambridge University Hospitals NHS Foundation Trus Dr David Wheeler A Phase 2 Study of BPM31510 (Ubidecarenone, USP) Nanosuspension Injection 11209 Quintiles Limited Dr Roopinder Gilmore Administered Intravenously 50012 SERENADE Actelion Pharmaceuticals UK Ltd Dr Gerry J Coghlan 50013 MAGMA study Newcastle upon Tyne Hospitals NHS Foundation Trust Dr Rachel Hung Royal Free London NHS Foundation Trust Open Studies

R&D No Short Title Sponsor Organisation Principal Investigator

50014 CREDO-4 CL04041024: Clinical Rheumatoid Arthritis Development for Olokizumab Quintiles Dr Voon Hong Ong

11211 Optalyse PE Biocompatibles UK Ltd Dr Gerry J Coghlan 11212 GPED Study University of the West of England, Bristol

11213 Pazopanib in advanced renal cell carcinoma after checkpoint inhibitor treatment Novartis Pharma AG Prof Thomas Powles

11214 Nucleos(t)ide withdrawal in Hepatitis B virus infection (NUC-B) Imperial College London Professor William Rosenberg 4296:NASH- Semaglutide in subjects with non-alcoholic steatohepatitis (SEMA- 11245 Novo Nordisk Ltd Emmanuel Tsochatzis NASH) 11246 CMR-CPET study The Royal Free Hospital Dr. Daniel Knight 11247 Determinants of prognosis in stroke Joint UCLH/UCL Biomedical Research (R&D) Unit Dr Daniel Epstein 11248 PREdiCCt study University of Edinburgh Dr Charles Murray 11249 A phase III study of Oxabact® in patients with primary hyperoxaluria OxThera Intellectual Property AB Dr Shabbir Moochhala A Two-Part, Open-Label, Randomized, Phase II/III Study of Dinutuximab and 11281 United Therapeutics Corporation Dr Ekaterini Boleti Irinotecan versus Irinotec 11282 Tumouroids UCL Miss Maxine Tran 11286 STASEY F. Hoffmann-La Roche Dr Pratima Chowdary 11287 PRedSS: Prednisolone in Early Diffuse Systemic Sclerosis. Version 1.0 The University of Manchester Prof Christopher Denton KEYNOTE-564 Ph3 Placebo-Controlled Trial-Adjuvant MK-3475 in RCC Post 11288 Merck Sharp & Dohme Ltd. (MSD) Prof Thomas Powles Nephrectomy 11290 A new test for ruling out colorectal cancer - The qFIT Pilot_v1 University College London Mr Massimo Varcada 11292 PLATO University of Leeds Dr Hemal Ariyaratne 11293 Piloting an end of life care educational intervention Royal College of Physicians Dr Philip Lodge 11295 Pre-implantation Trial of Histopathology in renal Allografts: PITHIA Cambridge University Hospitals NHS Foundation Trus Dr Gareth Jones 11296 InPath Royal Free London NHS Foundation Trust Dr Pratima Chowdary

11303 ViiV TANGO Phase 3 switch study -TAF regimen to DTG + 3TC in HIV-1 adults GSK Professor Margaret A Johnson CANC 35687 Retrospective study in the use of the alfapump and the Treatment of 11304 Sequana Medical AG Professor Rajiv Jalan Malignant Ascites 11306 Maternity Transformation Programme Midwife Workforce The University of Birmingham 11313 PIVOTALBoost ICR Dr Maria Vilarino-Varela 11318 Experiences and Needs of Patients with Pancreatic Cancer Oxford Brookes University Dr Roopinder Gillmore 11319 PIC Phase 1b Open-Label, Dose Escalation Study of PRTX-100 (PIC Study) Protalix Ltd 11326 OPTIPREM The Royal Wolverhampton NHS Trust Dr Tim Wickham 11328 OLT and Coagulation Royal Free London NHS Foundation Trust Dr Clare Melikian 11330 SNACC Survey (symptoms and nutrition after critical care) University of Plymouth Charlotte Cheeseman 11331 EPIC 3 Erasme University Hospital Dr Daniel Martin

11334 Incremental Dialysis to Preserve Residual Kidney Function (Incremental-HD) East and North Hertfordshire NHS Trust Dr Andrew Davenport

11337 Brain energy metabolism measured by magnetic resonance University of Oxford Dr Gabrielle Murphy 11338 CORGI 2 Oxford Professor Brian Davidson

11339 Surveillance of invasive Listeria infections in infants under 90 days of age St George's Hospital

11341 iMProveS Inventiva S.A. Dr Derralynn Hughes 11343 Virus and host immune system interaction during HIV-1 infection UCL Dr Sabine Kinloch-de-Loes 11344 RESOLVE-1 : Lenabasum in Diffuse Cutaneous Systemic Sclerosis Corbus Pharmaceuticals Ltd Prof Christopher Denton 11346 HJHS-VAPS v1.1 Guys and St Thomas NHS Trust Dr Pratima Chowdary 11349 Dose Ranging Trial of MK-8591 Given in Combination Therapy Merck Sharpe Dohme Prof Margaret Johnson CHIPS+: Optimising the health of young people with HIV in their transition from 11350 MRC Clinical Trials Unit at UCL Dr Sabine Kinloch-de-Loes paediatric to adult Royal Free London NHS Foundation Trust Open Studies

R&D No Short Title Sponsor Organisation Principal Investigator

11351 Development of a self-management behaviour scale for people with CKD East & North Hertfordshire NHS Trust Dr Andrew Davenport

11356 Osteoarthritis Thumb Therapy II Trial (OTTER II trial) University of Southampton Miss Juliette Bray 11357 Evaluation of the MicroGuide App for antibiotic guidelines Merck Sharp & Dohme Ltd. (MSD) 11363 BronchUK Study The Newcastle upon Tyne Hospitals NHS Foundation T Dr John Hurst 11365 The influence of motivational strategies on NHS nurses in the UK University of Sunderland ITUA AKPASUBI 11366 Health Status and Quality of Life in Congenital Agammaglob Newcastle University Dr Matthew Buckland 11375 TRACE Mitsubishi Pharma Europe Ltd (MPE) Dr Gerry J Coghlan 11376 1199.225 open label extension study of nintedanib in SSc-ILD Boehringer Ingelheim Limited Christopher Denton 11403 Treatment patterns of SCLC patients in Europe Quintiles Dr Ekaterini Boleti 11407 H4RT North Bristol NHS Trust Dr Andrew Davenport 2006/001 United Kingdom Paediatric Chronic ITP Registry Central Manchester and Manchester children's Unive 2009/002 Myeloma X: High versus low dose therapy for relapsed myeloma v3.0 Leeds Teaching Hospital NHS Trust Dr Andres Virchis 2011/001 "Prospective Utility Study of Patients with Multiple Cardiovascular Events F. Hoffmann La Roche Ltd 11421 OYNX ONE Medtronic Dr Sundeep Kalra

11427 BMN270-203 Gene Therapy Study in Patients with Antibodies Against AAV5 BioMarin Pharmaceutical Inc London Prof Amit Nathwani

11428 RED-HF Trial – Reduction of Events with Darbepoetin alfa in Heart Failure Trial Amgen (Europe) GmBH Dr Robert Greenbaum

11433 Natural History Study of C3G Imperial College London & Imperial Healthcare NHS Trust Dr Daniel Gale 11434 Hyperpolarised 13C-Pyruvate MRI study Joint UCLH/UCL Biomedical Research (R&D) Unit Miss Maxine Tran 11435 ECZTRA 3 LEO Pharma A/S Dr Mahreen Ameen 11439 AMBER: VAY736 in Autoimmune Hepatitis Novartis Pharma AG Dr Douglas Thorburn 11441 MIDFUT Leeds Teaching Hospitals NHS Trust Mr Richard Leigh 2011/58 Total or Partial Knee Arthroplasty Trial (TOPKAT) University of Oxford Mr Harold Nwaboku 11450 ARREST Kings College London Dr Roby Rakhit 11465 Study of efficacy and safety of CDZ173 in patients with APDS/ PASLI Novartis Pharma AG Dr Siobhan Burns 11469 Clinical and Genetic Characterisation of Gordon's Syndrome The University of Nottingham Dr Stephen Benedict Walsh 11471 Exploring the unmet need in cord blood banking University of the West of England Ms Marianne Renkin 11479 Clinical evaluation of a wearable sleep diagnosis technology Acurable Ltd Dr Swapna Mandal 11481 LoRETA UCL Miss Tara Mastracci 11482 The Second Conversation Model Kings College London (Denmark Hill Campus) Clinical Research Facility Dr Philip Lodge 11487 NEAT Long Term Chelsea and Westminster Hospital NHS Foundation Tr Prof Margaret Johnson 11504 DARWIN2 University College London Tanya Ahmad 11514 Pathfinder8 Novo Nordisk A/S Dr Pratima Chowdary 11545 Observational study in Gastric patients receiving Nivolumab in EAMS Bristol Myers Squibb Dr Astrid Meyer 11584 National cohort study of late effects of Hodgkin lymphoma treatment ICR Ms Sara Hamilton; Mrs Virginia Jennings