DOCSLIB.ORG

CONSUMER INFORMATION Increased Risk of Getting an Allergic Reaction That Is Passed Down Through Families

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
CONSUMER INFORMATION Increased Risk of Getting an Allergic Reaction That Is Passed Down Through Families IMPORTANT: PLEASE READ PART III: CONSUMER INFORMATION increased risk of getting an allergic reaction that is passed down through families. This can be triggered by different PrSandoz Trandolapril factors, such as surgery, flu, or dental procedures. Trandolapril Capsules You have diabetes or kidney disease and are already taking a blood pressure-lowering medicine that contains aliskiren Read this carefully before you start taking Sandoz (such as Rasilez®) or an angiotensin II receptor blocker Trandolapril and each time you get a refill. This leaflet is a (ARB). You can recognize ARBs because the name of their summary and will not tell you everything about Sandoz medicinal ingredient ends in “-sartan”. Trandolapril. Talk to your doctor, nurse, or pharmacist Are pregnant or intend to become pregnant. Taking Sandoz about your medical condition and treatment and ask if Trandolapril during pregnancy can cause injury and even there is any new information about Sandoz Trandolapril. death to your baby. Are breastfeeding. Sandoz Trandolapril passes into breast milk. ABOUT THIS MEDICATION Have one of the following rare hereditary diseases: o Galactose intolerance What the medication is used for: o Lapp lactase deficiency Sandoz Trandolapril is used to treat; o Glucose-galactose malabsorption High blood pressure. Because lactose is a non-medicinal ingredient in Sandoz Patients after a heart attack. Trandolapril. Managing your lifestyle What the medicinal ingredient is: The “lifestyle” part of your treatment is as important as Trandolapril your medication. In collaboration with your doctor, you can help reduce the risk of high blood pressure complications to What the non-medicinal ingredients are: maintain the lifestyle you are accustomed to. To do this, your Colloidal silicon dioxide, dimeticone, erythrosine, gelatin, doctor may discuss changes to your alcohol consumption and lactose monohydrate, magnesium stearate, microcrystalline your diet. Your doctor will also probably recommend regular cellulose, quinoline yellow, red iron oxide, starch exercise and to completely avoid smoking. pregelatinised, sunset yellow, titanium dioxide and yellow iron oxide. What it does: Sandoz Trandolapril is an angiotensin converting enzyme (ACE) What dosage forms it comes in: inhibitor. You can recognize ACE inhibitors because their Capsules: 0.5 mg, 1 mg, 2 mg and 4 mg. medicinal ingredient ends in ‘-PRIL’. This medicine does not cure your disease. It helps to control it. WARNINGS AND PRECAUTIONS Therefore, it is important to continue taking Sandoz Trandolapril regularly even if you feel fine. Serious Warnings and Precautions-Pregnancy Sandoz Trandolapril should not be used during pregnancy. If Although you may not feel any symptoms for years, high you discover that you are pregnant or you are planning to blood pressure can lead to stroke, heart attack, kidney disease become pregnant while taking Sandoz Trandolapril, stop the and other serious conditions. medication and contact your doctor, nurse, or pharmacist as soon as possible. Hypertension is the medical term for high blood pressure. When blood flows through the blood vessels it pushes against their walls, almost like water pushing against the sides of a BEFORE you use Sandoz Trandolapril talk to your doctor, hose. Blood pressure is like that “push”. When blood pressure nurse or pharmacist if you: is high (like the water pressure in a hose when the nozzle is partially shut), damage can occur to the heart and blood vessels. You are taking salt substitutes or foods containing potassium, potassium supplements, or a potassium-sparing When it should not be used: diuretic (a specific kind of “water pill”). Do not take Sandoz Trandolapril if you: Have diabetes, liver or kidney disease. Are allergic to trandolapril or any non-medicinal Have narrowing of an artery or heart valve disease. ingredients Have had a heart attack or stroke. Have experienced an allergic reaction (angioedema) with Have heart failure. swelling of the hands, feet, or ankles, face, lips, tongue, Are on dialysis. throat) or sudden difficulty breathing or swallowing, to any Are dehydrated or suffer from excessive vomiting, diarrhea, ACE inhibitor or without a known cause. Be sure to tell or sweating. your doctor, nurse, or pharmacist that this has happened to Are possibly allergic to Sandoz Trandolapril (or any drug you. used to lower blood pressure), including any of its non- Have been diagnosed with hereditary angioedema: an medicinal ingredients. (Refer to the subheading “What the non-medicinal ingredients are” for a complete listing). Sandoz Trandolapril Page 35 of 38 IMPORTANT: PLEASE READ Have recently received or are planning to get allergy shots transplanted organ or treat autoimmune diseases; for bee or wasp stings. Inhalation anesthetics; Are on a low-salt diet. mTOR (mammalian target of rapamycin) inhibitor (e.g., Are taking a medicine that contains aliskiren, such as temsirolimus, sirolimus, everolimus) therapy; Rasilez®, used to lower high blood pressure. The Lithium used to treat bipolar disease; combination with Sandoz Trandolapril is not recommended. Nifedipine SR used to treat chest pain or lower blood Are taking an angiotensin receptor blocker (ARB). You can pressure; recognize an ARB because its medicinal ingredient ends in “- Non-steroidal anti-inflammatory drugs (NSAIDs) used to SARTAN”. reduce pain and swelling. Examples include ibuprofen, Are receiving gold (sodium aurothiomalate) injections. naproxen, celecoxib, and acetylsalicylic acid (aspirin) used Are less than 18 years old. in higher doses; Have lupus or scleroderma. Procainamide used to treat irregular heartbeats; Systemic corticosteroids used to treat joint pain and swelling You may become sensitive to the sun while taking Sandoz Trandolapril. Exposure to sunlight should be minimized until you know how you respond. PROPER USE OF THIS MEDICATION If you are going to have surgery and will be given an anesthetic, Usual Adult Dose: be sure to tell your doctor or dentist that you are taking Sandoz Take Sandoz Trandolapril exactly as prescribed. Dosage Trandolapril. must be individualized The recommended initial dose of Sandoz Trandolapril is 1 mg once daily. The dose can be Driving and using machines: Before you perform tasks which increased over time by your doctor, up to a maximum may require special attention, wait until you know how you dose of 4 mg once daily. For patients with kidney or liver respond to Sandoz Trandolapril. Dizziness, lightheadedness, or impairment, the recommended initial dose is 0.5 mg once fainting can especially occur after the first dose and when the daily. dose is increased. It is recommended to take your dose at about the same time every day. You can take Sandoz Trandolapril with a INTERACTIONS WITH THIS MEDICATION meal, or if you prefer, on an empty stomach. As with most medicines, interactions with other drugs are With your first dose of Sandoz Trandolapril your blood possible. Tell your doctor, nurse, or pharmacist about all the pressure may drop too low and you may experience a medicines you take, including drugs prescribed by other doctors, sensation of lightheadedness. This effect should disappear vitamins, minerals, natural supplements, or alternative once your system becomes used to Sandoz Trandolapril. If medicines. they persist, discuss this with your doctor. Your medication may need to have the dose reduced or changed. The following may interact with Sandoz Trandolapril: Agents increasing serum potassium, such as a salt substitute Overdose: that contains potassium, potassium supplements, or a potassium-sparing diuretic (a specific kind of “water pill”; If you think you (or someone you know) may have examples include spironolactone, triamterene or amiloride); taken too much Sandoz Trandolapril, contact your Alcohol. It may cause low blood pressure, dizziness and doctor, nurse, pharmacist, hospital emergency fainting; department or regional Poison Control Centre Allopurinol, used to treat gout; immediately, even if there are no symptoms. Tell Antacids; them how much you have taken and show them the Antidepressants, used to control your depression; capsules Antidiabetic agents, including insulin and oral medicines used to control your blood glucose; Overdose symptoms expected with drugs like Sandoz Bee or wasp venom found in allergy shots for bee or wasp Trandolapril include a severe drop in blood pressure, shock, stings; stupor, and an abnormally slow heart beat. Blood pressure-lowering drugs, including diuretics (“water pills”,e.g., hydrochlorothiazide), aliskiren-containing Missed dose: products (e.g. Rasilez®), or angiotensin receptor blockers If you forget to take your dose of Sandoz Trandolapril, take it (ARBs); as soon as you remember, if you remember on the same day. If not, do not take your missed dose at all. Simply wait until it is Cytostatic agents used to treat cancers; time for your next dose. Do not double dose. Dextran sulphate used in low density lipoprotein apheresis to remove cholesterol from the blood; Digoxin used to treat irregular heartbeats; SIDE EFFECTS AND WHAT TO DO ABOUT THEM Gold for the treatment of rheumatoid arthritis; Immunosuppressive agents used to prevent rejection of a Like all medicines, Sandoz Trandolapril can cause side Sandoz Trandolapril Page 36 of 38 IMPORTANT: PLEASE READ effects. After you have started taking Sandoz Trandolapril it is SERIOUS SIDE EFFECTS, HOW OFTEN THEY important that you tell your doctor at once about any HAPPEN
Load more

Recommended publications
  • Renoprotective Effect of the Addition of Losartan to Ongoing Treatment with an Angiotensin Converting Enzyme Inhibitor in Type-2 Diabetic Patients with Nephropathy
    929 Hypertens Res Vol.30 (2007) No.10 p.929-935 Original Article Renoprotective Effect of the Addition of Losartan to Ongoing Treatment with an Angiotensin Converting Enzyme Inhibitor in Type-2 Diabetic Patients with Nephropathy Hirohiko ABE1), Shinya MINATOGUCHI1), Hiroshige OHASHI1), Ichijiro MURATA1), Taro MINAGAWA1), Toshio OKUMA1), Hitomi YOKOYAMA1), Hisato TAKATSU1), Tadatake TAKAYA1), Toshihiko NAGANO1), Yukio OSUMI1), Masao KAKAMI1), Tatsuo TSUKAMOTO1), Tsutomu TANAKA1), Kunihiko HIEI1), and Hisayoshi FUJIWARA1) Angiotensin converting enzyme inhibitors (ACE-Is) and angiotensin II receptor blockers (ARBs) are fre- quently used for the treatment for glomerulonephritis and diabetic nephropathy because of their albumin- uria- or proteinuria-reducing effects. To many patients who are nonresponsive to monotherapy with these agents, combination therapy appears to be a good treatment option. In the present study, we examined the effects of the addition of an ARB (losartan) followed by titration upon addition and at 3 and 6 months (n=14) and the addition of an ACE-I followed by titration upon addition and at 3 and 6 months (n=20) to the drug regimen treatment protocol in type 2 diabetic patients with nephropathy for whom more than 3-month administration of an ACE-I or the combination of an ACE-I plus a conventional antihypertensive was inef- fective to achieve a blood pressure (BP) of 130/80 mmHg and to reduce urinary albumin to <30 mg/day. Dur- ing the 12-month treatment, addition of losartan or addition of an ACE-I to the treatment protocol reduced systolic blood pressure (SBP) by 10% and 12%, diastolic blood pressure (DBP) by 7% and 4%, and urinary albumin excretion by 38% and 20% of the baseline value, respectively.
    [Show full text]
  • Ace Inhibitors (Angiotensin-Converting Enzyme)
    Medication Instructions Ace Inhibitors (Angiotensin-Converting Enzyme) Generic Brand Benazepril Lotensin Captopril Capoten Enalapril Vasotec Fosinopril Monopril Lisinopril Prinivil, Zestril Do not Moexipril Univasc Quinapril Accupril stop taking Ramipril Altace this medicine Trandolapril Mavik About this Medicine unless told ACE inhibitors are used to treat both high blood pressure (hypertension) and heart failure (HF). They block an enzyme that causes blood vessels to constrict. This to do so allows the blood vessels to relax and dilate. Untreated, high blood pressure can damage to your heart, kidneys and may lead to stroke or heart failure. In HF, using by your an ACE inhibitor can: • Protect your heart from further injury doctor. • Improve your health • Reduce your symptoms • Can prevent heart failure. Generic forms of ACE Inhibitors (benazepril, captopril, enalapril, fosinopril, and lisinopril) may be purchased at a lower price. There are no “generics” for Accupril, Altace Mavik, and of Univasc. Thus their prices are higher. Ask your doctor if one of the generic ACE Inhibitors would work for you. How to Take Use this drug as directed by your doctor. It is best to take these drugs, especially captopril, on an empty stomach one hour before or two hours after meals (unless otherwise instructed by your doctor). Side Effects Along with needed effects, a drug may cause some unwanted effects. Many people will not have any side effects. Most of these side effects are mild and short-lived. Check with your doctor if any of the following side effects occur: • Fever and chills • Hoarseness • Swelling of face, mouth, hands or feet or any trouble in swallowing or breathing • Dizziness or lightheadedness (often a problem with the first dose) Report these side effects if they persist: • Cough – dry or continuing • Loss of taste, diarrhea, nausea, headache or unusual fatigue • Fast or irregular heartbeat, dizziness, lightheadedness • Skin rash Special Guidelines • Sodium in the diet may cause you to retain fluid and increase your blood pressure.
    [Show full text]
  • Estonian Statistics on Medicines 2016 1/41
    Estonian Statistics on Medicines 2016 ATC code ATC group / Active substance (rout of admin.) Quantity sold Unit DDD Unit DDD/1000/ day A ALIMENTARY TRACT AND METABOLISM 167,8985 A01 STOMATOLOGICAL PREPARATIONS 0,0738 A01A STOMATOLOGICAL PREPARATIONS 0,0738 A01AB Antiinfectives and antiseptics for local oral treatment 0,0738 A01AB09 Miconazole (O) 7088 g 0,2 g 0,0738 A01AB12 Hexetidine (O) 1951200 ml A01AB81 Neomycin+ Benzocaine (dental) 30200 pieces A01AB82 Demeclocycline+ Triamcinolone (dental) 680 g A01AC Corticosteroids for local oral treatment A01AC81 Dexamethasone+ Thymol (dental) 3094 ml A01AD Other agents for local oral treatment A01AD80 Lidocaine+ Cetylpyridinium chloride (gingival) 227150 g A01AD81 Lidocaine+ Cetrimide (O) 30900 g A01AD82 Choline salicylate (O) 864720 pieces A01AD83 Lidocaine+ Chamomille extract (O) 370080 g A01AD90 Lidocaine+ Paraformaldehyde (dental) 405 g A02 DRUGS FOR ACID RELATED DISORDERS 47,1312 A02A ANTACIDS 1,0133 Combinations and complexes of aluminium, calcium and A02AD 1,0133 magnesium compounds A02AD81 Aluminium hydroxide+ Magnesium hydroxide (O) 811120 pieces 10 pieces 0,1689 A02AD81 Aluminium hydroxide+ Magnesium hydroxide (O) 3101974 ml 50 ml 0,1292 A02AD83 Calcium carbonate+ Magnesium carbonate (O) 3434232 pieces 10 pieces 0,7152 DRUGS FOR PEPTIC ULCER AND GASTRO- A02B 46,1179 OESOPHAGEAL REFLUX DISEASE (GORD) A02BA H2-receptor antagonists 2,3855 A02BA02 Ranitidine (O) 340327,5 g 0,3 g 2,3624 A02BA02 Ranitidine (P) 3318,25 g 0,3 g 0,0230 A02BC Proton pump inhibitors 43,7324 A02BC01 Omeprazole
    [Show full text]
  • Angiotensin-Converting Enzyme (ACE) Inhibitors
    Angiotensin-Converting Enzyme (ACE) Inhibitors Summary Blood pressure reduction is similar for the ACE inhibitors class, with no clinically meaningful differences between agents. Side effects are infrequent with ACE inhibitors, and are usually mild in severity; the most commonly occurring include cough and hypotension. Captopril and lisinopril do not require hepatic conversion to active metabolites and may be preferred in patients with severe hepatic impairment. Captopril differs from other oral ACE inhibitors in its rapid onset and shorter duration of action, which requires it to be given 2-3 times per day; enalaprilat, an injectable ACE inhibitor also has a rapid onset and shorter duration of action. Pharmacology Angiotensin Converting Enzyme Inhibitors (ACE inhibitors) block the conversion of angiotensin I to angiotensin II through competitive inhibition of the angiotensin converting enzyme. Angiotensin is formed via the renin-angiotensin-aldosterone system (RAAS), an enzymatic cascade that leads to the proteolytic cleavage of angiotensin I by ACEs to angiotensin II. RAAS impacts cardiovascular, renal and adrenal functions via the regulation of systemic blood pressure and electrolyte and fluid balance. Reduction in plasma levels of angiotensin II, a potent vasoconstrictor and negative feedback mediator for renin activity, by ACE inhibitors leads to increased plasma renin activity and decreased blood pressure, vasopressin secretion, sympathetic activation and cell growth. Decreases in plasma angiotensin II levels also results in a reduction in aldosterone secretion, with a subsequent decrease in sodium and water retention.[51035][51036][50907][51037][24005] ACE is found in both the plasma and tissue, but the concentration appears to be greater in tissue (primarily vascular endothelial cells, but also present in other organs including the heart).
    [Show full text]
  • M03-599 Clinical Study Report R&D/06/211
    ABT-897 M03-599 Clinical Study Report R&D/06/211 2.0 Synopsis Abbott Laboratories Individual Study Table Referring (For National Authority to Part of Dossier: Use Only) Name of Study Drug: Volume: Tarka® Name of Active Ingredient: Page: trandolapril and verapamil SR Title of Study: A Phase 4, Randomized, Open-Label, Active Controlled Study to Compare the Effects of Tarka® and Lotrel® on Albuminuria in Hypertensive, Type 2 Diabetic Subjects with Diabetic Nephropathy Investigator: Multicenter study. Coordinating investigator is Robert Toto, MD Study Sites: A total of 66 sites in the United States enrolled study subjects. Publications: None Studied Period (Years): Phase of Development: 4 First Subject First Visit: 07 Jan 2004 Last Subject Last Visit: 24 Jan 2006 Objectives: The primary objective of this study was to determine if trandolapril/verapamil SR (Tarka®) was superior to amlodipine/benazepril (Lotrel®) in the reduction of albuminuria in hypertensive subjects with Type 2 diabetes mellitus (DM) and diabetic nephropathy. Albuminuria was to be determined as the urine albumin:creatinine ratio (UACR). The secondary objectives of this study were: 1. To compare the effects of Tarka and Lotrel on changes in blood pressure (BP) and BP control, proteinuria, estimated glomerular filtration rate (GFR). 2. To compare antihypertensive drug use in each treatment group by drug, dose, and class. 3. To compare the safety profile of Tarka and Lotrel by evaluating lipid parameters, glycemic control, quality of life using the 36-Item Short Form Health Survey (SF-36), and adverse events. 4. From a substudy, to explore the effects of Tarka and Lotrel on serum high-sensitivity C-reactive protein (hsCRP), urinary malondialdehyde (MDA) and carbonylated proteins as oxidative stress markers, urinary monocyte chemotactic protein-1 (MCP-1) as an inflammatory marker, transforming growth factor-β (TGF- β) as a profibrotic marker, proteinuria selectivity index, and ambulatory blood pressure parameters.
    [Show full text]
  • Switching Ace-Inhibitors
    Switching Ace-inhibitors http://www.ksdl.kamsc.org.au/dtp/switching_ace_inhibitors.html Change to → Enalapril Quinapril Ramipril Change from ↓ (Once daily dosing) (Once daily dosing) (Once daily dosing) Captopril Captopril 12.5mg daily Enalapril 2.5mg1 Quinapril 2.5mg Ramipril 1.25mg Captopril 25mg daily Enalapril 5mg1 Quinapril 5mg Ramipril 1.25-2.5mg Captopril 50mg daily Enalapril 7.5mg1 Quinapril 10mg Ramipril 2.5-5mg Captopril 100mg daily Enalapril 20mg1 Quinapril 20mg Ramipril 5-10mg2 Captopril 150mg daily Enalapril 40mg Quinapril 40mg Ramipril 10mg Fosinopril Fosinopril 5mg daily Enalapril 5mg Quinapril 5mg Ramipril 1.25mg Fosinopril 10mg daily Enalapril 10mg Quinapril 10mg Ramipril 2.5mg Fosinopril 20mg daily Enalapril 20mg Quinapril 20mg Ramipril 5mg Fosinopril 40mg daily Enalapril 40mg Quinapril 40mg Ramipril 10mg Lisinopril Lisinopril 5mg daily Enalapril 5mg Quinapril 5mg Ramipril 1.25mg Lisinopril 10mg daily Enalapril 10mg Quinapril 10mg Ramipril 2.5mg Lisinopril 20mg daily Enalapril 20mg Quinapril 20mg Ramipril 5mg Lisinopril 40mg Enalapril 40mg Quinapril 40mg Ramipril 10mg Perindopril Perindopril 2mg daily Enalapril 5-10mg Quinapril 5-10mg Ramipril 2.5mg Perindopril 4mg daily Enalapril 10mg-20mg Quinapril 10mg-20mg Ramipril 5mg Perindopril 8mg daily Enalapril 20-40mg Quinapril 20-40mg Ramipril 10mg Trandolapril Trandolapril 0.5mg d Enalapril 5mg Quinapril 5mg Ramipril 1.25mg Trandolapril 1mg daily Enalapril 10mg Quinapril 10mg Ramipril 2.5mg Trandolapril 2mg daily Enalapril 20mg Quinapril 20mg Ramipril 5mg Trandolapril 4mg daily Enalapril 40mg Quinapril 40mg Ramipril 10mg There are few studies comparing equivalent doses of ACE-inhibitors, for specific indications. Therefore, the above recommendations are based on clinical experiences and are not specific for any indication.
    [Show full text]
  • The Treatment of Severe Hypertension with Trandolapril, Verapamil, and Hydrochlorothiazide
    Journal of Human Hypertension (1997) 11, 477–481 1997 Stockton Press. All rights reserved 0950-9240/97 $12.00 ORIGINAL ARTICLE The treatment of severe hypertension with trandolapril, verapamil, and hydrochlorothiazide HA Punzi1 and BA Novrit2 for the Trandolapril/Verapamil Multicenter Study Group 1Trinity Hypertension Research Center, Trinity Medical Center, Carrollton, TX; and 2Knoll Pharmaceutical Company, Mt Olive, NJ, USA A multiple drug regimen consisting of trandolapril, vera- than the decrease observed for the TV combination, pamil and hydrochlorothiazide (HCTZ) were sequentially which was significantly (P = 0.001) greater than the added in an open-label evaluation of patients with sev- decrease observed for trandolapril monotherapy. Clini- ere hypertension. Ninety patients (58 white and 32 black cal responder rates were 44.8%, 56% and 77.7% for tran- patients) were titrated on one or more drugs and fol- dolapril monotherapy, trandolapril + verapamil combi- lowed for a 19-week maintenance period. Statistically nation therapy and triple therapy, respectively. Black significant (P = 0.001) mean (± s.d.) decreases in supine and white patients had similar response rates, but black diastolic blood pressure (DBP) were 9.0 (±9.3) mm Hg patients appeared to benefit more from the addition of for trandolapril, 13.9 (±11.0) mm Hg for the trandolapril HCTZ; 20% of black patients achieved a post-treatment + verapamil (TV) combination, and 19.0 (±12.3) mm Hg supine DBP ,90 mm Hg compared to 12.8% of white when hydrochlorothiazide was added to the combi- patients. This study demonstrates that the addition of nation. The decrease in BP observed on TV combination verapamil to trandolapril has an additive effect on BP therapy plus HCTZ was significantly (P = 0.001) greater that is maintained throughout the day.
    [Show full text]
  • Sacubitril and Valsartan
    PATIENT & CAREGIVER EDUCATION Sacubitril and Valsartan This information from Lexicomp® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider. Brand Names: US Entresto Brand Names: Canada Entresto Warning Do not take if you are pregnant. Use during pregnancy may cause birth defects or loss of the unborn baby. If you get pregnant or plan on getting pregnant while taking this drug, call your doctor right away. What is this drug used for? It is used to treat heart failure (weak heart). It is used to lower the risk of death and having to go to the hospital because of heart failure. What do I need to tell my doctor BEFORE I take this drug? If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had. If you have liver disease. Sacubitril and Valsartan 1/6 If you have ever had a very bad or life-threatening reaction called angioedema. Signs may be swelling of the hands, face, lips, eyes, tongue, or throat; trouble breathing; trouble swallowing; unusual hoarseness. If you are taking another drug that has the same drug in it. If you are taking of these drugs: Azilsartan, candesartan, eprosartan, irbesartan, losartan, olmesartan, or telmisartan. If you are taking or have recently taken any of these drugs: Benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, or trandolapril. If you are taking a drug that has aliskiren in it and you also have diabetes or kidney problems.
    [Show full text]
  • PACKAGE LEAFLET: INFORMATION for the PATIENT Trandolapril 0.5 Mg, 1 Mg, 2 Mg and 4 Mg Capsules, Hard (Trandolapril)
    PACKAGE LEAFLET: INFORMATION FOR THE PATIENT Trandolapril 0.5 mg, 1 mg, 2 mg and 4 mg Capsules, hard (Trandolapril) Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. - Keep this leaflet. You may need to read it again. - If you have any further questions, ask your doctor or pharmacist. - This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours. - If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4. What is in this leaflet: 1. What Trandolapril is and what it is used for 2. What you need to know before you use Trandolapril 3. How to take Trandolapril 4. Possible side effects 5. How to store Trandolapril 6. Contents of the pack and other information 1. What Trandolapril is and what it is used for Trandolapril, the active ingredient in Trandolapril Capsules belongs to a group of medicines called angiotensin-converting enzyme inhibitors (sometimes called ACE inhibitors). ACE inhibitors work by relaxing the blood vessels which makes it easier for the heart to pump blood around the body. This helps to lower the blood pressure. Trandolapril is used to treat high blood pressure. It may also be used to help protect the heart after a heart attack. 2. What you need to know before you take Trandolapril Do not take Trandolapril if: - you are allergic to trandolapril, other ACE inhibitors (e.g.
    [Show full text]
  • ACE2 As a Therapeutic Target for COVID-19; Its Role in Infectious Processes and Regulation by Modulators of the RAAS System
    Journal of Clinical Medicine Review ACE2 as a Therapeutic Target for COVID-19; Its Role in Infectious Processes and Regulation by Modulators of the RAAS System Veronique Michaud 1,2, Malavika Deodhar 1, Meghan Arwood 1, Sweilem B Al Rihani 1, Pamela Dow 1 and Jacques Turgeon 1,2,* 1 Tabula Rasa HealthCare Precision Pharmacotherapy Research & Development Institute, Orlando, FL 32827, USA; [email protected] (V.M.); [email protected] (M.D.); [email protected] (M.A.); [email protected] (S.B.A.R.); [email protected] (P.D.) 2 Faculty of Pharmacy, Université de Montréal, Montreal, QC H3C 3J7, Canada * Correspondence: [email protected]; Tel.: +856-938-8793 Received: 11 June 2020; Accepted: 2 July 2020; Published: 3 July 2020 Abstract: Angiotensin converting enzyme 2 (ACE2) is the recognized host cell receptor responsible for mediating infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). ACE2 bound to tissue facilitates infectivity of SARS-CoV-2; thus, one could argue that decreasing ACE2 tissue expression would be beneficial. However, ACE2 catalytic activity towards angiotensin I (Ang I) and II (Ang II) mitigates deleterious effects associated with activation of the renin-angiotensin-aldosterone system (RAAS) on several organs, including a pro-inflammatory status. At the tissue level, SARS-CoV-2 (a) binds to ACE2, leading to its internalization, and (b) favors ACE2 cleavage to form soluble ACE2: these actions result in decreased ACE2 tissue levels. Preserving tissue ACE2 activity while preventing ACE2 shredding is expected to circumvent unrestrained inflammatory response. Concerns have been raised around RAAS modulators and their effects on ACE2 expression or catalytic activity.
    [Show full text]
  • TARKA® (Trandolapril/Verapamil Hydrochloride ER Tablets)
    TARKA® (trandolapril/verapamil hydrochloride ER tablets) WARNING: FETAL TOXICITY • When pregnancy is detected, discontinue TARKA as soon as possible. • Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus (see WARNINGS: Fetal Toxicity). DESCRIPTION TARKA (trandolapril/verapamil hydrochloride ER) combines a slow release formulation of a calcium channel blocker, verapamil hydrochloride, and an immediate release formulation of an angiotensin converting enzyme inhibitor, trandolapril. Verapamil Component Verapamil hydrochloride is chemically described as benzeneacetonitrile, α[3-[[2-(3,4­ dimethoxyphenyl)ethyl]methylamino]propyl]-3, 4-dimethoxy-α-(1-methylethyl) hydrochloride. Its empirical formula is C27H38N2O4 HCl and its structural formula is: Verapamil hydrochloride is an almost white crystalline powder, with a molecular weight of 491.08. It is soluble in water, chloroform, and methanol. It is practically free of odor, with a bitter taste. Trandolapril Component Trandolapril is the ethyl ester prodrug of a nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor, trandolaprilat. It is chemically described as (2S,3aR,7aS)-1-[(S)-N-[(S)-1-Carboxy-3­ phenylpropyl]alanyl] hexahydro-2-indolinecarboxylic acid, 1-ethyl ester. Its empirical formula is C24 H34 N2O5 and its structural formula is: Reference ID: 3957697 Trandolapril is a white or almost white powder with a molecular weight of 430.54. It is soluble (>100 mg/mL) in chloroform, dichloromethane, and methanol. TARKA tablets are formulated for oral administration, containing verapamil hydrochloride as a controlled release formulation and trandolapril as an immediate release formulation. The tablet strengths are trandolapril 2 mg/verapamil hydrochloride ER 180 mg, trandolapril 1 mg/verapamil hydrochloride ER 240 mg, trandolapril 2 mg/verapamil hydrochloride ER 240 mg, and trandolapril 4 mg/verapamil hydrochloride ER 240 mg.
    [Show full text]
  • Medicines for Cardiovascular Health
    Appendix Appendix tables Table A1: Supply of cardiovascular medicines in selected OECD countries, 2004 Medicine class Country ARA CCB BBA DIU AHYP ART GLY CHOL DDD/1,000 population/day Australia 146.9 77.0 25.5 39.4 5.2 2.2 5.3 161.8 Belgium 91.3 40.4 66.6 43.7 5.4 8.0 5.0 104.1 Czech Republic 105.1 69.9 71.3 95.5 12.2 5.6 7.1 65.0 Denmark(a) 85.1 46.2 29.9 111.5 2.7 1.6 6.3 67.2 Finland(a) 125.3 48.3 68.1 61.9 1.7 1.8 6.6 81.7 Germany(b) 143.8 48.8 67.6 65.9 11.6 2.3 10.1 57.3 Greece 149.4 68.6 30.7 35.7 6.7 5.5 9.9 84.0 Iceland 80.9 31.5 46.4 67.3 1.4 3.3 3.2 75.2 Norway(a) 99.1 46.6 39.4 45.4 n/a 1.3 4.4 110.0 Portugal(c) 109.7 37.0 18.3 42.4 0.3 7.3 6.8 71.1 Slovak Republic 88.8 63.3 42.8 31.7 10.7 4.3 6.6 31.5 Sweden(a) 85.6 40.7 54.7 87.3 1.9 1.1 6.5 75.2 ARA agents acting on renin–angiotensin system CCB calcium-channel blockers BBA beta-blocking agents DIU diuretics AHYP antihypertensives ART antiarrhythmics GLY cardiac glycosides CHOL serum-lipid-reducing agents n/a not available (a) Data for Denmark, Finland, Norway and Sweden cover supply of medicines in the community and in hospitals.
    [Show full text]