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Classification of Vasculitis Joseph L
Classification of Vasculitis Joseph L. Jorizzo A working classification of necrotizing vasculitis based on size of the affected vessel is proposed. The classification proposed by Gilliam and Fink in 1976 is a basis for the curren proposal. A revised working classification of vasculitis is presented. Small vessel necrotizing vasculitis and larger vessel necrotizing vasculitis categories are further subdivided. Improved understanding of the basic science aspects of vasculitis will hopefully give rise to a better consensus on the classification of vasculitis. J Invest Dermatol 100:106S–110S, 1993 A considerable portion of the now classic Medical Grand Rounds on SMALL VESSEL NECROTIZING VASCULITIS necrotizing vasculitis presented at The University of Texas Southwestern (NECROTIZING VENULITIS) Medical Center by James W. Gilliam in 1976 dealt with the classification of necrotizing vasculitis. Aspects of this presentation have been The hallmark of small-vessel necrotizing vasculitis is the diagnostic published (Table I) [1]. histopathologic finding of leukocytoclastic vasculitis including endothe- The historical context of Gilliam’s classification is important given the lial cell swelling, neutrophilic invasion of blood-vessel walls, leukocy- confounding array of classification schemas that preceded (and followed!) toclasia (neutrophilic nuclear karyorrhexis), extravasation of erythrocytes, and fibrinoid necrosis of blood vessel walls [14]. This it. The classification of vasculitis remains frustratingly controversial today. Zeek was the first to incorporate a clinicopathologic assessment process has been shown to affect post capillary venules [15,16]. This based on the size of the vessel involved in the inflammatory process in entity has been proposed as a cutaneous model for circulating immune his classification of necrotizing vasculitis in 1952 [2]. -
2016 Essentials of Dermatopathology Slide Library Handout Book
2016 Essentials of Dermatopathology Slide Library Handout Book April 8-10, 2016 JW Marriott Houston Downtown Houston, TX USA CASE #01 -- SLIDE #01 Diagnosis: Nodular fasciitis Case Summary: 12 year old male with a rapidly growing temple mass. Present for 4 weeks. Nodular fasciitis is a self-limited pseudosarcomatous proliferation that may cause clinical alarm due to its rapid growth. It is most common in young adults but occurs across a wide age range. This lesion is typically 3-5 cm and composed of bland fibroblasts and myofibroblasts without significant cytologic atypia arranged in a loose storiform pattern with areas of extravasated red blood cells. Mitoses may be numerous, but atypical mitotic figures are absent. Nodular fasciitis is a benign process, and recurrence is very rare (1%). Recent work has shown that the MYH9-USP6 gene fusion is present in approximately 90% of cases, and molecular techniques to show USP6 gene rearrangement may be a helpful ancillary tool in difficult cases or on small biopsy samples. Weiss SW, Goldblum JR. Enzinger and Weiss’s Soft Tissue Tumors, 5th edition. Mosby Elsevier. 2008. Erickson-Johnson MR, Chou MM, Evers BR, Roth CW, Seys AR, Jin L, Ye Y, Lau AW, Wang X, Oliveira AM. Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion. Lab Invest. 2011 Oct;91(10):1427-33. Amary MF, Ye H, Berisha F, Tirabosco R, Presneau N, Flanagan AM. Detection of USP6 gene rearrangement in nodular fasciitis: an important diagnostic tool. Virchows Arch. 2013 Jul;463(1):97-8. CONTRIBUTED BY KAREN FRITCHIE, MD 1 CASE #02 -- SLIDE #02 Diagnosis: Cellular fibrous histiocytoma Case Summary: 12 year old female with wrist mass. -
Update on Vasculitis: Overview and Relevant
An Bras Dermatol. 2020;95(4):493---507 Anais Brasileiros de Dermatologia www.anaisdedermatologia.org.br REVIEW Update on vasculitis: overview and relevant dermatological aspects for the clinical and ଝ,ଝଝ histopathological diagnosis --- Part II a,∗ b Thâmara Cristiane Alves Batista Morita , Paulo Ricardo Criado , b a a Roberta Fachini Jardim Criado , Gabriela Franco S. Trés , Mirian Nacagami Sotto a Department of Dermatology, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil b Dermatology Discipline, Faculdade de Medicina do ABC, Santo André, SP, Brazil Received 8 December 2019; accepted 28 April 2020 Available online 24 May 2020 Abstract Vasculitis is a group of several clinical conditions in which the main histopathological KEYWORDS finding is fibrinoid necrosis in the walls of blood vessels. This article assesses the main derma- Anti-neutrophil tological aspects relevant to the clinical and laboratory diagnosis of small- and medium-vessel cytoplasmic cutaneous and systemic vasculitis syndromes. The most important aspects of treatment are also antibodies; discussed. Churg-Strauss © 2020 Sociedade Brasileira de Dermatologia. Published by Elsevier Espana,˜ S.L.U. This is an syndrome; open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Henoch-Schönlein purple; Leukocytoclastic cutaneous vasculitis; Systemic vasculitis; Vasculitis; Vasculitis associated with lupus of the central nervous system ଝ How to cite this article: Morita TCAB, Criado PR, Criado RFJ, Trés GFS, Sotto MN. Update on vasculitis: overview and relevant dermato- logical aspects for the clinical and histopathological diagnosis --- Part II. An Bras Dermatol. 2020;95:493---507. ଝଝ Study conducted at the Department of Dermatology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil. -
Cutaneous Vasculitides: Clinico-Pathological Correlation
Original CCutaneousutaneous vasculitides:vasculitides: Clinico-pathologicalClinico-pathological Article ccorrelationorrelation SSuruchiuruchi Gupta,Gupta, SSanjeevanjeev HHanda,anda, AmrinderAmrinder J.J. Kanwar,Kanwar, BBishanishan DDassass RadotraRadotra 1, RRanjanaanjana WW.. MMinzinz 2 Departments of Dermatology, ABSTRACT Venereology, Leprology, 1Histopathology and Background: Cutaneous vasculitis presents as a mosaic of clinical and histological 2Immunopathology, Postgraduate Institute of Þ ndings. Its pathogenic mechanisms and clinical manifestations are varied. Aims: To Medical Education and study the epidemiological spectrum of cutaneous vasculitides as seen in a dermatologic Research, Chandigarh, India clinic and to determine the clinico-pathological correlation. Methods: A cohort study was conducted on 50 consecutive patients clinically diagnosed as cutaneous vasculitis in the AAddressddress forfor ccorrespondence:orrespondence: dermatology outdoor; irrespective of age, sex and duration of the disease. Based on the Prof. Sanjeev Handa, clinical presentation, vasculitis was classiÞ ed according to modiÞ ed Gilliam’s classiÞ cation. Departments of Dermatology, All patients were subjected to a baseline workup consisting of complete hemogram, Venereology and Leprology, Postgraduate Institute of serum-creatinine levels, serum-urea, liver function tests, chest X-ray, urine (routine and Medical Education and microscopic) examination besides antistreptolysin O titer, Mantoux test, cryoglobulin levels, Research, Chandigarh, India antineutrophilic cytoplasmic antibodies and hepatitis B and C. Histopathological examination E-mail: was done in all patients while immunoß uorescence was done in 23 patients. Results: Out [email protected] of a total of 50 patients diagnosed clinically as cutaneous vasculitis, 41 were classiÞ ed as leukocytoclastic vasculitis, 2 as Heinoch−Schonlein purpura, 2 as urticarial vasculitis and one each as nodular vasculitis, polyarteritis nodosa and pityriasis lichenoid et varioliforme acuta. -
Review Isolated Vasculitis of the Peripheral Nervous System
Review Isolated vasculitis of the peripheral nervous system M.P. Collins, M.I. Periquet Department of Neurology, Medical College ABSTRACT combination therapy to be more effec- of Wisconsin, Milwaukee, Wisconsin, USA. Vasculitis restricted to the peripheral tive than prednisone alone. Although Michael P. Collins, MD, Ass. Professor; nervous system (PNS), referred to as most patients have a good outcome, M. Isabel Periquet, MD, Ass. Professor. nonsystemic vasculitic neuropathy more than 30% relapse and 60% have Please address correspondence and (NSVN), has been described in many residual pain. Many nosologic, path- reprint requests to: reports since 1985 but remains a poorly ogenic, diagnostic, and therapeutic Michael P. Collins, MD, Department of understood and perhaps under-recog- questions remain unanswered. Neurology, Medical College of Wisconsin, nized condition. There are no uniform 9200 W. Wisconsin Avenue, Milwaukee, WI 53226, USA. diagnostic criteria. Classifi cation is Introduction E-mail: [email protected] complicated by the occurrence of vas- The vasculitides comprise a broad Received on March 6, 2008; accepted in culitic neuropathies in many systemic spectrum of diseases which exhibit, revised form on April 1, 2008. vasculitides affecting small-to-me- as their primary feature, infl ammation Clin Exp Rheumatol 2008; 26 (Suppl. 49): dium-sized vessels and such clinical and destruction of vessel walls, with S118-S130. variants as nonsystemic skin/nerve secondary ischemic injury to the in- © CopyrightCopyright CLINICAL AND vasculitis and diabetic/non-diabetic volved tissues (1). They are generally EXPERIMENTAL RHEUMATOLOGY 2008.2008. lumbosacral radiculoplexus neuropa- classifi ed based on sizes of involved thy. Most patients present with pain- vessels and histopathologic and clini- Key words: Vasculitis, peripheral ful, stepwise progressive, distal-pre- cal features. -
Panniculitis Martin C
Panniculitis Martin C. Mihm M.D. Director – Mihm Cutaneous Pathology Consultative Service (MCPCS) Brigham and Women’s Hospital Director – Melanoma Program Brigham and Women’s Hospital and Harvard Medical School Co-Director – Melanoma Program Dana-Farber Cancer Institute and Harvard Medical School Conflicts of Interest • Chairman Scientific Advisory Board – Caliber I.D. Inc. • Member Scientific Advisory Board – MELA Sciences Inc. • Consultant – Novartis • Consultant – Alnylam Disorders of the Subcutis • Septal • Lobular • Mixed • Inflammatory (N/G/L) • Pauci-inflammatory 1 Septal Panniculitis • Erythema nodosum • Necrobiosis lipoidica • Morphea profundus Erythema Nodosum Clinical Features • Young adults • Nodular or plaque like lesions • Anterior aspect of lower legs (common) • Arms or abdomen (occurs occasionally) • Clinical course • Initially erythematous, painful area • Evolves into nodule or plaque • Lasts 10 days to 8 weeks • Fever, malaise, arthralgias (variable s/s) Erythema Nodosum Clinical Features Causation • Systemic diseases: CTD, Behcet’s, Sweet’s, sarcoidosis,etc. • Drugs: Numerous drugs have been associated: penicillin, sulfa, Cipro, isotretinoin, etc. • 30%: idiopathic or of unknown cause.. 2 3 Erythema nodosum : Well Developed Lesion • Septal fibrosis • Septal chronic inflammation • Lymphocytes • Frank Vasculitis may not be present • Granulomatous changes • Small granulomatous aggregates of histiocytes • Miescher’s radial granuloma • Multinucleated giant cells 4 5 6 Erythema nodosum : Morphologic Clues to underlying etiology -
Clinics & R Rmatolog Dermatology Clinics & Research
DermatologyDermatolog ClinicsClinics && ResearchResearch DCR, 1(3): 49-52 wwww.scitcentral.comww .scitcentral.com ISSN: 2380-5609 Original Case Report: Open Access An Annular Variant of Nodular Vasculitis: A Case Report Tetsuya Higuchi*, Yuko Takano, Masami Yoshida Department of Dermatology, Sakura Medical Center, School of Medicine, Toho University, Japan Received July , 8 2015; Accepted August 25, 2015; Published November 30, 201, 2015 ABSTRACT Panniculitis is classified histologically into distinct categories based on the location of inflammation in the subcutaneous tissue, and the presence of vasculitis. Nodular vasculitis (NV) is defined as predominantly lobular panniculitis with large vessel vasculitis. We present the case of a 73-year-old Japanese woman presenting with painful, annular, erythematous plaques on the trunk and extremities. Each erythematous plaque developed centrifugally and subsided with reticular pigmentation in a few months. Histological examination revealed lobular panniculitis and vasculitis, involving both the arteries and veins; thus, she was diagnosed with NV. The erythema continued to flare intermittently, and systemic administration of prednisolone alleviated the eruptions. We believe that the present case is unique in both annular morphology and distribution of eruptions. Keywords: Nodular vasculitis, Annular variant, Cyclosporine INTRODUCTION results of laboratory investigations including pancreatic Nodular vasculitis (NV) is defined as predominantly lobular panniculitis with large vessel vasculitis [1-4]. The enzymes and liver functions, were normal. Autoantibodies, indurated, painful, erythematous plaques of NV are typically such as anti-nuclear antibody, anti -DNA antibody, found in the lower extremities. Here, we present a rare case proteinase 3-antineutrophil cytoplasmic antibody (PR3- of annularly developing erythema diagnosed histologically ANCA), and myeloperoxidase ANCA (MPO -ANCA), were as NV, and the differential diagnosis not detected. -
Update on Vasculitis: Overview and Relevant
An Bras Dermatol. 2020;95(4):493---507 Anais Brasileiros de Dermatologia www.anaisdedermatologia.org.br REVIEW Update on vasculitis: overview and relevant dermatological aspects for the clinical and ଝ,ଝଝ histopathological diagnosis --- Part II a,∗ b Thâmara Cristiane Alves Batista Morita , Paulo Ricardo Criado , b a a Roberta Fachini Jardim Criado , Gabriela Franco S. Trés , Mirian Nacagami Sotto a Department of Dermatology, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil b Dermatology Discipline, Faculdade de Medicina do ABC, Santo André, SP, Brazil Received 8 December 2019; accepted 28 April 2020 Available online 24 May 2020 Abstract Vasculitis is a group of several clinical conditions in which the main histopathological KEYWORDS finding is fibrinoid necrosis in the walls of blood vessels. This article assesses the main derma- Anti-neutrophil tological aspects relevant to the clinical and laboratory diagnosis of small- and medium-vessel cytoplasmic cutaneous and systemic vasculitis syndromes. The most important aspects of treatment are also antibodies; discussed. Churg-Strauss © 2020 Sociedade Brasileira de Dermatologia. Published by Elsevier Espana,˜ S.L.U. This is an syndrome; open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Henoch-Schönlein purple; Leukocytoclastic cutaneous vasculitis; Systemic vasculitis; Vasculitis; Vasculitis associated with lupus of the central nervous system ଝ How to cite this article: Morita TCAB, Criado PR, Criado RFJ, Trés GFS, Sotto MN. Update on vasculitis: overview and relevant dermato- logical aspects for the clinical and histopathological diagnosis --- Part II. An Bras Dermatol. 2020;95:493---507. ଝଝ Study conducted at the Department of Dermatology, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil. -
Liposuction in Dercum's Disease. Clinical Studies Regarding Dercum's Disease and the Effect of Liposuction
Liposuction in Dercum's disease. Clinical studies regarding Dercum's disease and the effect of liposuction. Hansson, Emma 2011 Link to publication Citation for published version (APA): Hansson, E. (2011). Liposuction in Dercum's disease. Clinical studies regarding Dercum's disease and the effect of liposuction. Department of Plastic and Reconstructive Surgery, Malmö University Hospital, Malmö, Sweden,. Total number of authors: 1 General rights Unless other specific re-use rights are stated the following general rights apply: Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Read more about Creative commons licenses: https://creativecommons.org/licenses/ Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. LUND UNIVERSITY PO Box 117 221 00 Lund +46 46-222 00 00 Emma Hansson Liposuction in Dercum’s disease 2011 Liposuction in Dercum’s Hansson Emma Liposuction in Dercum’s -
2014 Slide Library Case Summary Questions & Answers With
2014 Slide Library Case Summary Questions & Answers with Discussions 51st Annual Meeting November 6-9, 2014 Chicago Hilton & Towers Chicago, Illinois The American Society of Dermatopathology ARTHUR K. BALIN, MD, PhD, FASDP FCAP, FASCP, FACP, FAAD, FACMMSCO, FASDS, FAACS, FASLMS, FRSM, AGSF, FGSA, FACN, FAAA, FNACB, FFRBM, FMMS, FPCP ASDP REFERENCE SLIDE LIBRARY November 2014 Dear Fellows of the American Society of Dermatopathology, The American Society of Dermatopathology would like to invite you to submit slides to the Reference Slide Library. At this time there are over 9300 slides in the library. The collection grew 2% over the past year. This collection continues to grow from member’s generous contributions over the years. The slides are appreciated and are here for you to view at the Sally Balin Medical Center. Below are the directions for submission. Submission requirements for the American Society of Dermatopathology Reference Slide Library: 1. One H & E slide for each case (if available) 2. Site of biopsy 3. Pathologic diagnosis Not required, but additional information to include: 1. Microscopic description of the slide illustrating the salient diagnostic points 2. Clinical history and pertinent laboratory data, if known 3. Specific stain, if helpful 4. Clinical photograph 5. Additional note, reference or comment of teaching value Teaching sets or collections of conditions are especially useful. In addition, infrequently seen conditions are continually desired. Even a single case is helpful. Usually, the written submission requirement can be fulfilled by enclosing a copy of the pathology report prepared for diagnosis of the submitted case. As a guideline, please contribute conditions seen with a frequency of less than 1 in 100 specimens. -
Consultations in Medical Dermatology Joseph L
Consultations In Medical Dermatology Joseph L. Jorizzo, MD Professor of Clinical Dermatology Weill Cornell Medical College New York, NY Professor, Founder and Former Chair Department of Dermatology Wake Forest School of Medicine Winston-Salem, NC Conflict of Interest Advisory Boards/Honoraria Amgen Leo Pharmaceuticals Quote from an anonymous patient: “What I am told on the first visit is patient education – on the second an excuse.” Possibilities for a patient who presents with a complex medical dermatosis and systemic signs and symptoms: 1. Clinicopathologic diagnosis of dermatosis integrates all findings eg. Sarcoidosis – skin, eye, lungs, etc 2. Clinicopathologic diagnosis reveals a reactive dermatosis – communication with internist or pediatrician will outline underlying medical conditions eg. Vasculitis 3. No direct relationship – eg. Scabies/Fibromyalgia Patients wishes to know from the internet whether they need x or y therapy for their presumptive diagnosis. Instead it is important to not let the patient “drive” for their own benefit. Step 1. – Clinicopathologic diagnosis- Caution influence of therapy on biopsy and clinical appearance Step 2. – Assess the extent (internal manifestations of disease) Step 3. – Assess for etiology Step 4. - Therapeutic ladder Lichen Planus Key Features • Idiopathic, inflammatory disease of the skin, hair, nails and mucous membranes, seen most commonly in middle-aged adults • Flat-topped violaceous papules and plaques favoring the wrists, forearms, genitalia, distal lower extremities and presacral -
Systemic Sclerosis: a Case Study
DERMATOLOGY OFFICE PLANNING: RADIO FREQUENCY FROM DESICCATORS TURNING ON AUTOMATIC FAUCETS AND TOWEL DISPENSERS Jonathan S. Crane, D.O., F.A.O.C.D.,* Christine Cook, BS,* David George Jackson, BS, ** Pete Buskirk, P.E.,*** Erin Griffin, DO, PGY 2**** *Atlantic Dermatology Associates, P.A., Wilmington, NC **University of North Carolina at Wilmington, Wilmington, NC ***Lee Cowper Construction, Wilmington, NC **** New Hanover Regional Medical Center, Wilmington, NC ABSTRACT In opening our brand-new, 20,000 square-foot dermatology facility, we were excited to have the latest technology. We opted for hands-free faucets and hands-free towel dispensers so as to minimize disease spread. At first we were very excited about the new technology, until we discovered that electrodessication could trigger the water faucets and towel dispensers. This in turn wasted paper and soaked both employees and other equipment. It became so frustrating that we ended up replacing over 20 faucets throughout the office, moving back to the old, hand-operated technology. We don’t want others to make this same mistake. Introduction We used hands-free faucets provided by Delta manufacturer, and the hands-free paper-towel dispensers were Tork Intuition Hand Towel Dispensers. Both the faucets and the towel dispensers work by detecting infrared radiation instead of responding to touch. The infrared detectors in the faucets are powered via the wall outlet; the dispensers are powered with three D batteries.1,2 We soon found that both of these technologies would also be turned on when we used our AARON 900 desiccators, provided by Bovie Medical. These desiccators use “disposable dermal tips,” which serve the function of limiting the spread of disease, much like the sensors do.3 The radio frequency emitted by this machine is 550 kHz (5.5x105 Hz).