DOCSLIB.ORG

Ritmos Circadianos De Cua- Tro Cuerpos Académicos Y 3 Grupos De Trabajo De La Unam

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Ritmos Circadianos De Cua- Tro Cuerpos Académicos Y 3 Grupos De Trabajo De La Unam 240 pp = 1.3 cm os ritmos biológicos están en toda la naturaleza, pero sus caracterís- L ticas particulares de duración y hora de su mayor expresión varían ampliamente entre las especies. En humanos el ritmo más evidente es RITMOS el ciclo sueño-vigilia; toda nuestra fisiología y funciones están asocia- MARIO CABA (coordinadores) dos a este ciclo. Así, algunas hormonas se secretan al despertar, como VALDEZ PABLO los glucocorticoides, mientras que otras se secretan al dormir, como la melatonina. Estos ritmos se denominan circadianos, ya que se repiten con un período de aproximadamente 24 horas y están controlados a CIRCADIANOS nivel celular por un grupo de genes llamados reloj. El presente libro es resultado del trabajo de investigación sobre ritmos circadianos de cua- tro cuerpos académicos y 3 grupos de trabajo de la UNAM. Los temas van DE LA CÉLULA desde aspectos básicos hasta ritmos en el recién nacido, a nivel metabó- lico, conductual, en el envejecimiento y en procesos patológicos como el cáncer. Se ilustra la gran importancia que tienen los ritmos circadianos para nuestra vida diaria así como las graves consecuencias que su alte- AL SER HUMANO ración puede ocasionar. Mario Caba. Biólogo, Universidad Veracruzana. Maestría y Doctorado en Biología de la Reproducción en el CIRA-Universidad Autónoma de Tlaxcala y Postdoctorado en el Oregon National Primate Research Cen- ter en EE.UU. Estudia ritmos circadianos en el conejo, contribuyendo a que se reconozca al conejo neonato como un modelo natural de sincro- nización por alimento y al conocimiento de las bases neuroendocrinas de la conducta maternal. Actualmente es Nivel III del Sistema Nacional de Investigadores. Pablo Valdez. Psicólogo, Universidad Nacional Autónoma de México. Maestría y Doctorado en la Universidad Autónoma de Nuevo León. Estudia la cronobiología del comportamiento humano, específicamente los ritmos circadianos en los procesos cognoscitivos, así como los efec- tos de los cambios de horario en el ciclo de sueño-vigilia. Actualmente es Nivel II en el Sistema Nacional de Investigadores.. RITMOS CIRCADIANOS DE LA CÉLULA AL SER HUMANO AL CÉLULA RITMOS CIRCADIANOS DE LA MARIO CABA PABLO VALDEZ (coordinadores) UV Universidad Veracruzana Esta obra se encuentra disponible en Acceso Abierto para copiarse, distribuirse y transmitirse con propósitos no comerciales. Todas las formas de reproducción, adaptación y/o traducción por medios mecánicos o electrónicos deberán indicar como fuente de origen a la obra y su(s) autor(es). Se debe obtener autorización de la Universidad Veracruzana para cualquier uso comercial. La persona o institución que distorsione, mutile o modifique el contenido de la obra será responsable por las acciones legales que genere e indemnizará a la Universidad Veracruzana por cualquier obligación que surja conforme a la legislación aplicable. RITMOS CIRCADIANOS DE LA ◄ CÉLULA ◄ AL SER HUMANO Quehacer científico y tecnológico Ritmos circadianosCon.indd 3 07/01/16 12:53 UNIVERSIDAD VERACRUZANA Sara Ladrón de Guevara Rectora Leticia Rodríguez Audirac Secretaria Académica Clementina Guerrero García Secretaria de Administración y Finanzas Octavio Ochoa Contreras Secretario de la Rectoría Édgar García Valencia Director Editorial Ritmos circadianosCon.indd 4 07/01/16 12:53 RITMOS CIRCADIANOS DE LA ◄ CÉLULA ◄ AL SER HUMANO MARIO CABA Y PABLO VALDEZ (coordinadores) UNIVERSIDAD VERACRUZANA XALAPA, VER., MÉXICO 2015 Ritmos circadianosCon.indd 5 07/01/16 12:53 Maquetación de forros y collage digital de portada: Jorge Cerón Ruiz Clasificación LC: QP84.6 R57 2015 Clasif. Dewey: 612.022 Título: Ritmos circadianos : de la célula al ser humano / Mario Caba y Pablo Valdez (coordinadores). Edición: Primera edición. Pie de imprenta: Xalapa, Ver., México : Universidad Veracruzana, 2015. Descripción física: 246 páginas : ilustraciones ; 26 cm. Serie: Quehacer científico y tecnológico ISBN: 9786075024202 Materias: Ritmos circadianos. Cronobiología. Cronofarmacología. Autores relacionados: Caba, Mario. Valdez, Pablo. DGBUV 2015/47 Primera edición, 20 de noviembre de 2015 D. R. © Universidad Veracruzana Dirección Editorial Hidalgo núm. 9, Centro, CP 91000 Xalapa, Veracruz, México Apartado postal 97 [email protected] Tel./fax (01228) 8 18 59 80; 8 18 13 88 ISBN: 978-607-502-420-2 Este libro ha sido publicado con el apoyo de la Dirección General de Desarrollo Académico e Innovación Educativa de la UV, como parte del programa de Fortalecimiento de Cuerpos Académicos Impreso en México Printed in Mexico Ritmos circadianosCon.indd 6 07/01/16 12:53 CONTENIDO Prólogo, 9 Ruud M. Buijs Prefacio, 11 Mario Caba y Pablo Valdez .1. INTRODUCCIÓN A LA CRONOBIOLOGÍA, 13 Pablo Valdez Ramírez, Candelaria Ramírez Tule y Aída García García .2. EL SISTEMA CIRCADIANO DE LOS MAMÍFEROS, 33 Raúl Aguilar Roblero y José Luis Chávez Ritmos circadianosCon.indd 7 07/01/16 12:53 .3. RITMOS CIRCADIANOS EN EL RECIÉN NACIDO, 53 Manuel Ángeles Castellanos, Samuel Vázquez Ruiz, Adelina Rojas Granados, Laura Ubaldo y Carolina Escobar .4. REGULACIÓN GENÉTICA, EPIGENÉTICA Y METABÓLICA DE LOS RITMOS CIRCADIANOS, 71 Adrián Báez Ruiz, Vania Carmona Alcocer, Isabel Méndez y Mauricio Díaz Muñoz .5. EL CONEJO NEONATO, UN MODELO NATURAL DE SINCRONIZACIÓN POR ALIMENTO, 101 Mario Caba, Enrique Meza y María Luisa Moreno .6. ASPECTOS CRONOBIOLÓGICOS DE LA OBESIDAD Y EL SÍNDROME METABÓLICO, 123 Roberto Salgado Delgado, Carolina Escobar y Nadia Saderi Ritmos circadianosCon.indd 8 07/01/16 12:53 .7. EFECTOS DE LA VIDA MODERNA SOBRE LA SOMNOLENCIA. UN ESTUDIO EN ESTUDIANTES UNIVERSITARIOS, 147 María del Carmen Cortés, José Ramón Eguibar y María del Carmen Lara .8. LOS CAMBIOS EN LA ATENCIÓN A LO LARGO DEL DÍA EN EL SER HUMANO, 165 Aída García García, Candelaria Ramírez Tule y Pablo Valdez Ramírez .9. RITMOS CIRCADIANOS Y TURNOS DE TRABAJO, 179 Candelaria Ramírez Tule, Aída García García y Pablo Valdez Ramírez .10. RITMOS CIRCADIANOS Y LA RESPUESTA DE NUESTRO ORGANISMO A LOS MEDICAMENTOS, 193 Enrique Meza, Stefan Waliszewski, Rossana Citlali Zepeda y Mario Caba Ritmos circadianosCon.indd 9 07/01/16 12:53 .11. RITMOS CIRCADIANOS Y CÁNCER, 207 Rossana Citlali Zepeda, Enrique Meza, Stefan Waliszewski y Mario Caba .12. RITMOS CIRCADIANOS Y ENVEJECIMIENTO: IMPLICACIONES PARA LA SALUD Y LA LONGEVIDAD, 223 Lance J. Kriegsfeld y Mario Caba Ritmos circadianosCon.indd 10 07/01/16 12:53 PRÓLOGO Los ritmos biológicos han sido estudiados desde hace muchos años y se ha podido demostrar su gran influencia en la vida de todas las especies de este planeta. Los de tipo estacional, por ejemplo, influyen en gran variedad de organismos, especialmente en el hemisferio norte, donde la supervivencia ante las duras condiciones climáticas que trae el invierno obliga a muchos animales a hibernar. Los ritmos estacionales, a su vez, impulsan el ciclo reproductivo, de tal manera que las crías nacen hacia el final de esta estación, lo que les ofrece las condiciones óptimas para buscar alimento durante la primavera y el verano. Del mismo modo, los ritmos de las mareas también son afectados por los ciclos de la luna alre- dedor de la tierra, lo que estimula la reproducción de muchos animales que viven en el mar o cerca de él. Por otra parte, los ritmos circadianos, que son el tópico de este libro, están determinados por la diaria rotación de la tierra y los ciclos luz/oscuri- dad de aproximadamente 24 horas. Estos eternos ciclos han sido la causa de que todas las especies del planeta tierra hayan desarrollado genes reloj que les permiten sincronizar su vida a ritmos de 24 horas aun sin la luz del sol. En el caso de los mamíferos los genes reloj se encuentran en todas las células, pero es en el sistema nervioso central, especialmente en el núcleo supraquiasmático –una pequeña estructura en la base del hipo- tálamo–, donde su expresión ha sido más estudiada. En el hipotálamo se regulan muchas funciones fundamentales de nuestro cuerpo, desde la ingesta de alimento, el control de la presión sanguínea, la regulación de la temperatura y la reproducción. 11 Ritmos circadianosCon.indd 11 07/01/16 12:53 En los últimos treinta años los estudios en animales de experimenta- ción han demostrado que el núcleo supraquiasmático o reloj biológico tiene una alta capacidad de influir en todas las funciones del ritmo dia- rio. Este ritmo se ajusta a los cambios constantes del ciclo luz/oscuridad a lo largo del día; al mismo tiempo que es autónomo gracias al ritmo de los genes reloj en las neuronas, que forman asas de retroalimentación entrelazadas dando como resultado un ciclo de 24 horas de actividad eléctrica neuronal, la cual se transmite a las estructuras blanco en el hipotálamo. Esta actividad rítmica en el hipotálamo del individuo le permite, por su fisiología, anticipar la conducta asociada a los ciclos de luz y oscuridad. Anteriormente se pensaba que los ritmos de 24 horas no afectaban a la especie humana, dado que nosotros podemos prescindir casi libre- mente de las señales del reloj biológico. Sin embargo, ahora ha quedado claro que el comportamiento y la fisiología humana están fuertemente asociadados a la influencia del reloj biológico. En la actualidad se está in- vestigando ampliamente el hecho de que podamos ignorar las señales de nuestro reloj biológico y su impacto en el desarrollo de las enfermedades. El presente libro tiene como objetivo presentar algunas problemáticas asociadas a las alteraciones en nuestro reloj biológico. Se muestran los resultados de investigaciones realizadas con animales que permiten aclarar los mecanismos básicos de las interacciones entre dicho reloj y los diferentes tejidos de nuestro cuerpo. Se expone un punto de vista muy certero sobre cómo los ciclos de la luz y la noche pueden influir no sólo en los patrones de sueño y aprendizaje, sino también en la fisiología de los bebés que nacen prematuramente y que crecen en las salas de los hospitales bajo una iluminación continua. Con la información de este libro el lector podrá entender que la habili- dad que los seres humanos tenemos de ignorar nuestro reloj biológico y sucumbir a los malos hábitos de mantenernos de pie y comer durante la noche, cuando el organismo indica que es tiempo de dormir, trae conse- cuencias irreversibles.
Load more

Recommended publications
  • The Circadian Clock Modulates Core Steps in Long-Term Memory Formation in Aplysia
    8662 • The Journal of Neuroscience, August 23, 2006 • 26(34):8662–8671 Cellular/Molecular The Circadian Clock Modulates Core Steps in Long-Term Memory Formation in Aplysia Lisa C. Lyons, Maria Sol Collado, Omar Khabour, Charity L. Green, and Arnold Eskin Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204-5001 The circadian clock modulates the induction of long-term sensitization (LTS) in Aplysia such that long-term memory formation is significantly suppressed when animals are trained at night. We investigated whether the circadian clock modulated core molecular processes necessary for memory formation in vivo by analyzing circadian regulation of basal and LTS-induced levels of phosphorylated mitogen-activated protein kinase (P-MAPK) and Aplysia CCAAT/enhancer binding protein (ApC/EBP). No basal circadian regulation occurred for P-MAPK or total MAPK in pleural ganglia. In contrast, the circadian clock regulated basal levels of ApC/EBP protein with peak levels at night, antiphase to the rhythm in LTS. Importantly, LTS training during the (subjective) day produced greater increases in P-MAPK and ApC/EBP than training at night. Thus, circadian modulation of LTS occurs, at least in part, by suppressing changes in key proteins at night. Rescue of long-term memory formation at night required both facilitation of MAPK and transcription in conjunction with LTS training, confirming that the circadian clock at night actively suppresses MAPK activation and transcription involved in memory formation. The circadian clock appears to modulate LTS at multiple levels. 5-HT levels are increased more when animals receive LTS training during the (subjective) day compared with the night, suggesting circadian modulation of 5-HT release.
    [Show full text]
  • COVID-19, the Circadian Clock, and Critical Care
    JBRXXX10.1177/0748730421992587Journal of Biological RhythmsHaspel et al. / Short Title 992587research-article2021 REVIEW A Timely Call to Arms: COVID-19, the Circadian Clock, and Critical Care Jeffrey Haspel*,1, Minjee Kim†, Phyllis Zee†, Tanja Schwarzmeier‡ , Sara Montagnese§ , Satchidananda Panda||, Adriana Albani‡,¶ and Martha Merrow‡,2 *Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, Missouri, USA, †Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA, ‡Institute of Medical Psychology, Faculty of Medicine, LMU Munich, Munich, Germany, §Department of Medicine, University of Padova, Padova, Italy, ||Salk Institute for Biological Studies, La Jolla, California, USA, and ¶Department of Medicine IV, LMU Munich, Munich, Germany Abstract We currently find ourselves in the midst of a global coronavirus dis- ease 2019 (COVID-19) pandemic, caused by the highly infectious novel corona- virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we discuss aspects of SARS-CoV-2 biology and pathology and how these might interact with the circadian clock of the host. We further focus on the severe manifestation of the illness, leading to hospitalization in an intensive care unit. The most common severe complications of COVID-19 relate to clock-regulated human physiology. We speculate on how the pandemic might be used to gain insights on the circadian clock but, more importantly, on how knowledge of the circadian clock might be used to mitigate the disease expression and the clinical course of COVID-19. Keywords circadian clock, critical care, COVID-19, SARS-CoV-2, nutrition, zeitgeber, rhythm INTRODUCTION disease much about the pathophysiology of COVID- 19 and its causative agent, severe acute respiratory Coronavirus disease 2019 (COVID-19) is a new syndrome coronavirus 2 (SARS-CoV-2; Zhu et al., 2020), remains to be clarified.
    [Show full text]
  • Spatial Memory Deficits, Increased Phosphorylation of the Transcription Factor CREB, and Induction of the AP-1 Complex Following Experimental Brain Injury
    The Journal of Neuroscience, March 1995, 15(a): 2030-2039 Spatial Memory Deficits, Increased Phosphorylation of the Transcription Factor CREB, and Induction of the AP-1 Complex Following Experimental Brain Injury Pramod K. Dash,’ Anthony N. Moore,’ and C. Edward Dixon2 ‘Deoartment of Neurobiolonv and Anatomy and *Department of Neurosurgery, University of Texas-Houston Health Scikce Center, Houston, Texas 77225 . Traumatic brain injury causes both short- and long-term genes, which may change the functional properties of nerve cells neurological impairments. A cascade of biochemical (Goelet et al., 1986; Morgan and Curran, 1991). Therefore, it is changes triggered by the injury may increase the expres- possible that the functional deficits observed following TBI may sion of several genes, which has been hypothesized to be, in part, attributable to the pathophysiologic expression of contribute to the observed cognitive deficits. The mecha- specific neuronal late-effector genes activated by these kinases. nism(s) of induction for these genes is not yet known. We The cyclic adenosine monophosphate (CAMP) response ele- present evidence that lateral cortical impact injury in rats ment binding protein (CREB) is a member of the ATF (activat- that produces spatial memory deficits also increases phos- ing transcription factor) family of proteins. CREB mediates the phorylation of the transcription factor CREB (CAMP re- expression of several immediate-early genes (IEGs) in response sponse element binding). Subsequent to the phosphoryla- to agents that increase intracellular concentrations of CAMP or tion of CREB, c-Fos expression and the AP-1 complex are Ca2+ (Montminy et al., 1986; Hymann et al., 1988; Hoeffler et enhanced.
    [Show full text]
  • SRBR 2004 Program Book
    Ninth Meeting Society for Research on Biological Rhythms Program and Abstracts SRS/SRBR June 23, 2004 SRBR June 24–26, 2004 Whistler Resort • Whistler, British Columbia SOCIETY FOR RESEARCH ON BIOLOGICAL RHYTHMS i Executive Committee Editorial Board Ralph E. Mistleberger Simon Fraser University Steven Reppert, President Serge Daan University of Massachusetts Medical University of Groningen School Larry Morin SUNY, Stony Brook Bruce Goldman William Schwartz, President-Elect University of Connecticut University of Massachusetts Medical Hitoshi Okamura Kobe University School of Medicine School Terry Page Vanderbilt University Carla Green, Secretary Steven Reppert University of Massachusetts Medical University of Virginia Ueli Schibler School University of Geneva Fred Davis, Treasurer Mark Rollag Northeastern University Michael Terman Uniformed Services University Columbia University Helena Illnerova, Member-at-Large Benjamin Rusak Czech. Academy of Sciences Advisory Board Dalhousie University Takao Kondo, Member-at-Large Timothy J. Bartness Nagoya University Georgia State University Laura Smale Michigan State University Anna Wirz-Justice, Member-at-Large Vincent M. Cassone Centre for Chronobiology Texas A & M University Rae Silver Columbia University Journal of Biological Russell Foster Rhythms Imperial College of Science Martin Straume University of Virginia Jadwiga M. Giebultowicz Editor-in-Chief Oregon State University Elaine Tobin Martin Zatz University of California, Los Angeles National Institute of Mental Health Carla Green University of Virginia Fred Turek Associate Editors Northwestern University Eberhard Gwinner Josephine Arendt Max Planck Institute G.T.J. van der Horst University of Surrey Erasmus University Paul Hardin Michael Hastings University of Houston David R. Weaver MRC, Cambridge University of Massachusetts Medical Helena Illerova Center Ken-Ichi Honma Czech.
    [Show full text]
  • Levels of Serotonin in the Hemolymph of Aplysiaare Modulated by Light
    The Journal of Neuroscience, September 15, 1999, 19(18):8094–8103 Levels of Serotonin in the Hemolymph of Aplysia Are Modulated by Light/Dark Cycles and Sensitization Training Jonathan Levenson,1 John H. Byrne,2 and Arnold Eskin1 1Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204-5513, and 2Department of Neurobiology and Anatomy, University of Texas–Houston Medical School, Houston, Texas 77225 Serotonin (5-hydroxytryptamine, 5-HT) modulates the behavior crease of 5-HT in the hemolymph 24 hr after sensitization and physiology of both vertebrate and invertebrate animals. training indicates that training caused a long-lasting increase in Effects of injections of 5-HT and the morphology of the sero- the release of 5-HT. This long-lasting increase in 5-HT in the tonergic system of Aplysia indicate that 5-HT may have a hemolymph was blocked by treatment with an inhibitor of humoral, in addition to a neurotransmitter, role. To study pos- protein synthesis during training. Based on the levels of 5-HT in sible humoral roles of 5-HT, we measured 5-HT in the hemo- the hemolymph and its regulation by environmental events, we lymph. The concentration of 5-HT in the hemolymph was ;18 propose that 5-HT has a humoral role in regulation of the nM, a value close to previously reported thresholds for eliciting behavioral state of Aplysia. In support of this hypothesis, we physiological responses. The concentration of 5-HT in the he- found that increasing levels of 5-HT in the hemolymph led to molymph expressed a diurnal rhythm.
    [Show full text]
  • By Treatments Producing Long-Term Facilitation in Aplysia Raymond E
    Downloaded from learnmem.cshlp.org on October 10, 2021 - Published by Cold Spring Harbor Laboratory Press Identification of Specific mRNAs Affected by Treatments Producing Long-Term Facilitation in Aplysia Raymond E. Zwartjes, 1 Henry West, 1 Samer Hattar, 1 Xiaoyun Ren, 1 Florence Noel, 2 Marta Nufiez-Regueiro, 1 Kathleen MacPhee, 1 Ramin Homayouni, 1 Michael T. Crow, 3 John H. Byrne, 2 and Arnold Eskin 1'4 1Department of Biochemical and Biophysical Sciences University of Houston Houston, Texas 77204-5934 2Department of Neur0bi010gy and Anatomy University of Texas-H0ust0n Medical School Houston, Texas 77030 3Ger0nt010gy Research Center National Institute on Aging National Institutes of Health Baltimore, Maryland 21224 Abstract by sensitization training. Furthermore, stimulation of peripheral nerves of Neural correlates of long-term pleural-pedal ganglia, an in vitro analog of sensitization of defensive withdrawal sensitization training, increased the reflexes in Aplysia occur in sensory incorporation of labeled amino acids into neurons in the pleural ganglia and can be CaM, PGK, and protein 3. These results mimicked by exposure of these neurons to indicate that increases in CaM, PGK, and serotonin (5-HT). Studies using inhibitors protein 3 are part of the early response of indicate that transcription is necessary for sensory neurons to stimuli that produce production of long-term facilitation by 5-HT. long-term facilitation, and that CaM and Several mRNAs that change in response to protein 3 could have a role in the 5-HT have been identified, but the molecular generation of long-term sensitization. events responsible for long-term facilitation have not yet been fully described.
    [Show full text]
  • Different Mechanisms Exist for the Plasticity of Glutamate Reuptake During Early Long-Term Potentiation (LTP) and Late LTP
    The Journal of Neuroscience, October 11, 2006 • 26(41):10461–10471 • 10461 Cellular/Molecular Different Mechanisms Exist for the Plasticity of Glutamate Reuptake during Early Long-Term Potentiation (LTP) and Late LTP Juan D. Pita-Almenar, Maria Sol Collado, Costa M. Colbert, and Arnold Eskin Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204-5001 Regulation of glutamate reuptake occurs along with several forms of synaptic plasticity. These associations led to the hypothesis that regulation of glutamate uptake is a general component of plasticity at glutamatergic synapses. We tested this hypothesis by determining whether glutamate uptake is regulated during both the early phases (E-LTP) and late phases (L-LTP) of long-term potentiation (LTP). We found that glutamate uptake was rapidly increased within minutes after induction of LTP and that the increase in glutamate uptake persisted for at least3hinCA1ofthehippocampus. NMDA receptor activation and Na ϩ-dependent high-affinity glutamate transporters were responsible for the regulation of glutamate uptake during all phases of LTP. However, different mechanisms appear to be respon- sible for the increase in glutamate uptake during E-LTP and L-LTP. The increase in glutamate uptake observed during E-LTP did not requirenewproteinsynthesis,wasmediatedbyPKCbutnotcAMP,andaspreviouslyshownwasattributabletoEAAC1(excitatoryamino acidcarrier-1),aneuronalglutamatetransporter.Ontheotherhand,theincreaseinglutamateuptakeduringL-LTPrequirednewprotein synthesis and was mediated by the cAMP–PKA (protein kinase A) pathway, and it involved a different glutamate transporter, GLT1a (glutamate transporter subtype 1a). The switch in mechanisms regulating glutamate uptake between E-LTP and L-LTP paralleled the differences in the mechanisms responsible for the induction of E-LTP and L-LTP.
    [Show full text]
  • Circadian Clocks in Fish—What Have We Learned So Far?
    biology Review Circadian Clocks in Fish—What Have We Learned so far? Inga A. Frøland Steindal and David Whitmore * Department of Cell and Developmental Biology, University College London, 21 University Street, London WC1E 6DE, UK; [email protected] * Correspondence: [email protected] Received: 7 December 2018; Accepted: 9 March 2019; Published: 19 March 2019 Abstract: Zebrafish represent the one alternative vertebrate, genetic model system to mice that can be easily manipulated in a laboratory setting. With the teleost Medaka (Oryzias latipes), which now has a significant following, and over 30,000 other fish species worldwide, there is great potential to study the biology of environmental adaptation using teleosts. Zebrafish are primarily used for research on developmental biology, for obvious reasons. However, fish in general have also contributed to our understanding of circadian clock biology in the broadest sense. In this review, we will discuss selected areas where this contribution seems most unique. This will include a discussion of the issue of central versus peripheral clocks, in which zebrafish played an early role; the global nature of light sensitivity; and the critical role played by light in regulating cell biology. In addition, we also discuss the importance of the clock in controlling the timing of fundamental aspects of cell biology, such as the temporal control of the cell cycle. Many of these findings are applicable to the majority of vertebrate species. However, some reflect the unique manner in which “fish” can solve biological problems, in an evolutionary context. Genome duplication events simply mean that many fish species have more gene copies to “throw at a problem”, and evolution seems to have taken advantage of this “gene abundance”.
    [Show full text]
  • COVID-19, the Circadian Clock, and Critical Care
    JBRXXX10.1177/0748730421992587Journal of Biological RhythmsHaspel et al. / Short Title 992587research-article2021 REVIEW A Timely Call to Arms: COVID-19, the Circadian Clock, and Critical Care Jeffrey Haspel*,1, Minjee Kim†, Phyllis Zee†, Tanja Schwarzmeier‡ , Sara Montagnese§ , Satchidananda Panda||, Adriana Albani‡,¶ and Martha Merrow‡,2 *Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, Missouri, USA, †Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA, ‡Institute of Medical Psychology, Faculty of Medicine, LMU Munich, Munich, Germany, §Department of Medicine, University of Padova, Padova, Italy, ||Salk Institute for Biological Studies, La Jolla, California, USA, and ¶Department of Medicine IV, LMU Munich, Munich, Germany Abstract We currently find ourselves in the midst of a global coronavirus dis- ease 2019 (COVID-19) pandemic, caused by the highly infectious novel corona- virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we discuss aspects of SARS-CoV-2 biology and pathology and how these might interact with the circadian clock of the host. We further focus on the severe manifestation of the illness, leading to hospitalization in an intensive care unit. The most common severe complications of COVID-19 relate to clock-regulated human physiology. We speculate on how the pandemic might be used to gain insights on the circadian clock but, more importantly, on how knowledge of the circadian clock might be used to mitigate the disease expression and the clinical course of COVID-19. Keywords circadian clock, critical care, COVID-19, SARS-CoV-2, nutrition, zeitgeber, rhythm INTRODUCTION disease much about the pathophysiology of COVID- 19 and its causative agent, severe acute respiratory Coronavirus disease 2019 (COVID-19) is a new syndrome coronavirus 2 (SARS-CoV-2; Zhu et al., 2020), remains to be clarified.
    [Show full text]
  • Genetics of Sleep Section Fred W
    Genetics of Sleep Section Fred W. Turek 3 11 Introduction 15 Genetic Basis of Sleep in Healthy 12 Circadian Clock Genes Humans 13 Genetics of Sleep in a Simple Model 16 Genetics of Sleep and Sleep Disorders in Organism: Drosophila Humans 14 Genetic Basis of Sleep in Rodents Chapter Introduction Fred W. Turek 11 The inclusion for the first time of a specific Section on all, of 24-hour behavioral, physiologic, and cellular genetics in Principles and Practice of Sleep Medicine is a her- rhythms of the body. The simplicity and ease of moni- alding event as it signifies that the study of the genetic toring a representative “output rhythm” of the central control of the sleep–wake cycle is becoming an important circadian clock from literally thousands of rodents in a approach for understanding not only the regulatory mech- single laboratory, such as the precise rhythm of wheel anisms underlying the regulation of sleep and wake but running in rodents, was a major factor in uncovering the also for elucidating the function of sleep. Indeed, as genetic molecular transcriptional and translational feedback loops approaches are being used for the study of sleep in diverse that give rise to 24-hour output signals.4,5 There is now species from flies to mice to humans (see Chapters 13 to substantial evidence demonstrating that deletion or muta- 16), the evolutionary significance for the many functions tions in many canonical circadian clock genes can lead of sleep that have evolved over time are becoming a trac- to fundamental changes in other sleep–wake traits includ- table subject for research, as many researchers are bringing ing the amount of sleep and the response to sleep depri- the tools of genetics and genomics to the sleep field.
    [Show full text]
  • Long-Term Regulation of Neuronal High-Affinity Glutamate and Glutamine Uptake in Aplysia
    Long-term regulation of neuronal high-affinity glutamate and glutamine uptake in Aplysia Jonathan Levenson*, Shogo Endo*†, Lorna S. Kategaya*, Raymond I. Fernandez*, David G. Brabham*, Jeannie Chin‡, John H. Byrne‡, and Arnold Eskin*§ *University of Houston, Department of Biology and Biochemistry, 4800 Calhoun Road, Houston, TX 77204-5513; and ‡Department of Neurobiology and Anatomy, University of Texas, Houston Medical School, Houston, TX 77225 Edited by Eric R. Kandel, Columbia University, New York, NY, and approved August 22, 2000 (received for review June 5, 2000) An increase in transmitter release accompanying long-term sensi- Beach, CA). They were maintained at 15°C under 12-h light/12-h tization and facilitation occurs at the glutamatergic sensorimotor dark and fed every 2–3 days. Animals were in the lab for 3 days synapse of Aplysia. We report that a long-term increase in neuronal before use. Experiments investigating duration of siphon with- Glu uptake also accompanies long-term sensitization. Synapto- drawal after long-term sensitization training or exposure to somes from pleural-pedal ganglia exhibited sodium-dependent, 5-hydroxytryptamine (5-HT; serotonin) in vivo were performed high-affinity Glu transport. Different treatments that induce long- as described (6, 11). term enhancement of the siphon-withdrawal reflex, or long-term Uptake was measured by using a synaptosomal preparation synaptic facilitation increased Glu uptake. Moreover, 5-hydroxy- tryptamine, a treatment that induces long-term facilitation, also derived from pleural-pedal ganglia as described (Fig. 3A; ref. 29). produced a long-term increase in Glu uptake in cultures of sensory Animals were anesthetized with an injection of isotonic MgCl2.
    [Show full text]
  • (Tolloid/BMP-1) Is Regulated in Aplysia Neurons by Treatments That Induce Long-Term Sensitization
    The Journal of Neuroscience, January 15, 1997, 17(2):755–764 A Developmental Gene (Tolloid/BMP-1) Is Regulated in Aplysia Neurons by Treatments that Induce Long-Term Sensitization Qing-R Liu,1 Samer Hattar,1 Shogo Endo,1 Kathleen MacPhee,1 Han Zhang,2 Leonard J. Cleary,2 John H. Byrne,2 and Arnold Eskin1 1Department of Biochemical and Biophysical Sciences, University of Houston, Houston, Texas 77204, and 2Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, Texas 77225 Long-term sensitization training, or procedures that mimic the increased by serotonin and behavioral training was 41–45% training, produces long-term facilitation of sensory-motor neu- identical to a developmentally regulated gene family which ron synapses in Aplysia. The long-term effects of these proce- includes Drosophila tolloid and human bone morphogenetic dures require mRNA and protein synthesis (Montarolo et al., protein-1 (BMP-1). Both tolloid and BMP-1 encode metallopro- 1986; Castellucci et al., 1989). Using the techniques of differ- teases that might activate TGF-b (transforming growth factor ential display reverse transcription PCR (DDRT-PCR) and ribo- b)-like molecules or process procollagens. Aplysia tolloid/BMP- nuclease protection assays (RPA), we identified a cDNA whose 1-like protein (apTBL-1) might regulate the morphology and mRNA level was increased significantly in sensory neurons by efficacy of synaptic connections between sensory and motor treatments of isolated pleural-pedal ganglia with serotonin for neurons, which are associated with long-term sensitization. 1.5 hr or by long-term behavioral training of Aplysia. The effects of serotonin and behavioral training on this mRNA were mim- Key words: Aplysia; tolloid; metalloprotease; sensitization; icked by treatments that elevate cAMP.
    [Show full text]