REST API and the Packages for R and Python Omadb
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Applied Category Theory for Genomics – an Initiative
Applied Category Theory for Genomics { An Initiative Yanying Wu1,2 1Centre for Neural Circuits and Behaviour, University of Oxford, UK 2Department of Physiology, Anatomy and Genetics, University of Oxford, UK 06 Sept, 2020 Abstract The ultimate secret of all lives on earth is hidden in their genomes { a totality of DNA sequences. We currently know the whole genome sequence of many organisms, while our understanding of the genome architecture on a systematic level remains rudimentary. Applied category theory opens a promising way to integrate the humongous amount of heterogeneous informations in genomics, to advance our knowledge regarding genome organization, and to provide us with a deep and holistic view of our own genomes. In this work we explain why applied category theory carries such a hope, and we move on to show how it could actually do so, albeit in baby steps. The manuscript intends to be readable to both mathematicians and biologists, therefore no prior knowledge is required from either side. arXiv:2009.02822v1 [q-bio.GN] 6 Sep 2020 1 Introduction DNA, the genetic material of all living beings on this planet, holds the secret of life. The complete set of DNA sequences in an organism constitutes its genome { the blueprint and instruction manual of that organism, be it a human or fly [1]. Therefore, genomics, which studies the contents and meaning of genomes, has been standing in the central stage of scientific research since its birth. The twentieth century witnessed three milestones of genomics research [1]. It began with the discovery of Mendel's laws of inheritance [2], sparked a climax in the middle with the reveal of DNA double helix structure [3], and ended with the accomplishment of a first draft of complete human genome sequences [4]. -
UNIVERSITY of CALIFORNIA SAN DIEGO Making Sense of Microbial
UNIVERSITY OF CALIFORNIA SAN DIEGO Making sense of microbial populations from representative samples A dissertation submitted in partial satisfaction of the requirements for the degree Doctor of Philosophy in Computer Science by James T. Morton Committee in charge: Professor Rob Knight, Chair Professor Pieter Dorrestein Professor Rachel Dutton Professor Yoav Freund Professor Siavash Mirarab 2018 Copyright James T. Morton, 2018 All rights reserved. The dissertation of James T. Morton is approved, and it is acceptable in quality and form for publication on microfilm and electronically: Chair University of California San Diego 2018 iii DEDICATION To my friends and family who paved the road and lit the journey. iv EPIGRAPH The ‘paradox’ is only a conflict between reality and your feeling of what reality ‘ought to be’ —Richard Feynman v TABLE OF CONTENTS Signature Page . iii Dedication . iv Epigraph . .v Table of Contents . vi List of Abbreviations . ix List of Figures . .x List of Tables . xi Acknowledgements . xii Vita ............................................. xiv Abstract of the Dissertation . xvii Chapter 1 Methods for phylogenetic analysis of microbiome data . .1 1.1 Introduction . .2 1.2 Phylogenetic Inference . .4 1.3 Phylogenetic Comparative Methods . .6 1.4 Ancestral State Reconstruction . .9 1.5 Analysis of phylogenetic variables . 11 1.6 Using Phylogeny-Aware Distances . 15 1.7 Challenges of phylogenetic analysis . 18 1.8 Discussion . 19 1.9 Acknowledgements . 21 Chapter 2 Uncovering the horseshoe effect in microbial analyses . 23 2.1 Introduction . 24 2.2 Materials and Methods . 34 2.3 Acknowledgements . 35 Chapter 3 Balance trees reveal microbial niche differentiation . 36 3.1 Introduction . -
Standardised Benchmarking in the Quest for Orthologs
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Harvard University - DASH Standardised Benchmarking in the Quest for Orthologs The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters Citation Altenhoff, A. M., B. Boeckmann, S. Capella-Gutierrez, D. A. Dalquen, T. DeLuca, K. Forslund, J. Huerta-Cepas, et al. 2016. “Standardised Benchmarking in the Quest for Orthologs.” Nature methods 13 (5): 425-430. doi:10.1038/nmeth.3830. http://dx.doi.org/10.1038/ nmeth.3830. Published Version doi:10.1038/nmeth.3830 Citable link http://nrs.harvard.edu/urn-3:HUL.InstRepos:29408292 Terms of Use This article was downloaded from Harvard University’s DASH repository, and is made available under the terms and conditions applicable to Other Posted Material, as set forth at http:// nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of- use#LAA HHS Public Access Author manuscript Author ManuscriptAuthor Manuscript Author Nat Methods Manuscript Author . Author manuscript; Manuscript Author available in PMC 2016 October 04. Published in final edited form as: Nat Methods. 2016 May ; 13(5): 425–430. doi:10.1038/nmeth.3830. Standardised Benchmarking in the Quest for Orthologs Adrian M. Altenhoff1,2, Brigitte Boeckmann3, Salvador Capella-Gutierrez4,5,6, Daniel A. Dalquen7, Todd DeLuca8, Kristoffer Forslund9, Jaime Huerta-Cepas9, Benjamin Linard10, Cécile Pereira11,12, Leszek P. Pryszcz4, Fabian Schreiber13, Alan Sousa da Silva13, Damian Szklarczyk14,15, Clément-Marie Train1, Peer Bork9,16,17, Odile Lecompte18, Christian von Mering14,15, Ioannis Xenarios3,19,20, Kimmen Sjölander21, Lars Juhl Jensen22, Maria J. -
Multiscale Modeling in Systems Biology
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 2051 Multiscale Modeling in Systems Biology Methods and Perspectives ADRIEN COULIER ACTA UNIVERSITATIS UPSALIENSIS ISSN 1651-6214 ISBN 978-91-513-1225-5 UPPSALA URN urn:nbn:se:uu:diva-442412 2021 Dissertation presented at Uppsala University to be publicly examined in 2446 ITC, Lägerhyddsvägen 2, Uppsala, Friday, 10 September 2021 at 10:15 for the degree of Doctor of Philosophy. The examination will be conducted in English. Faculty examiner: Professor Mark Chaplain (University of St Andrews). Abstract Coulier, A. 2021. Multiscale Modeling in Systems Biology. Methods and Perspectives. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 2051. 60 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-1225-5. In the last decades, mathematical and computational models have become ubiquitous to the field of systems biology. Specifically, the multiscale nature of biological processes makes the design and simulation of such models challenging. In this thesis we offer a perspective on available methods to study and simulate such models and how they can be combined to handle biological processes evolving at different scales. The contribution of this thesis is threefold. First, we introduce Orchestral, a multiscale modular framework to simulate multicellular models. By decoupling intracellular chemical kinetics, cell-cell signaling, and cellular mechanics by means of operator-splitting, it is able to combine existing software into one massively parallel simulation. Its modular structure makes it easy to replace its components, e.g. to adjust the level of modeling details. We demonstrate the scalability of our framework on both high performance clusters and in a cloud environment. -
OMA, a Comprehensive, Automated Project for the Identification of Orthologs from Complete Genome Data: Introduction and First Achievements
OMA, A Comprehensive, Automated Project for the Identification of Orthologs from Complete Genome Data: Introduction and First Achievements Christophe Dessimoz, Gina Cannarozzi, Manuel Gil, Daniel Margadant, Alexander Roth, Adrian Schneider, and Gaston H. Gonnet ETH Zurich, Institute of Computational Science, CH-8092 Z¨urich [email protected] Abstract. The OMA project is a large-scale effort to identify groups of orthologs from complete genome data, currently 150 species. The algo- rithm relies solely on protein sequence information and does not require any human supervision. It has several original features, in particular a verification step that detects paralogs and prevents them from being clustered together. Consistency checks and verification are performed throughout the process. The resulting groups, whenever a comparison could be made, are highly consistent both with EC assignments, and with assignments from the manually curated database HAMAP. A highly ac- curate set of orthologous sequences constitutes the basis for several other investigations, including phylogenetic analysis and protein classification. Complete genomes give scientists a valuable resource to assign functions to se- quences and to analyze their evolutionary history. These analyses rely heavily on gene comparison through sequence alignment algorithms that output the level of similarity, which gives an indication of homology. When homologous sequences are of interest, care must often be taken to distinguish between orthologous and paralogous proteins [1]. Both orthologs and paralogs come from the same ancestral sequence, and therefore are homologous, but they differ in the way they arise: paralogous se- quences are the product of gene duplication, while orthologous sequences are the product of speciation. -
Daniel Aalberts Scott Aa
PLOS Computational Biology would like to thank all those who reviewed on behalf of the journal in 2015: Daniel Aalberts Jeff Alstott Benjamin Audit Scott Aaronson Christian Althaus Charles Auffray Henry Abarbanel Benjamin Althouse Jean-Christophe Augustin James Abbas Russ Altman Robert Austin Craig Abbey Eduardo Altmann Bruno Averbeck Hermann Aberle Philipp Altrock Ferhat Ay Robert Abramovitch Vikram Alva Nihat Ay Josep Abril Francisco Alvarez-Leefmans Francisco Azuaje Luigi Acerbi Rommie Amaro Marc Baaden Orlando Acevedo Ettore Ambrosini M. Madan Babu Christoph Adami Bagrat Amirikian Mohan Babu Frederick Adler Uri Amit Marco Bacci Boris Adryan Alexander Anderson Stephen Baccus Tinri Aegerter-Wilmsen Noemi Andor Omar Bagasra Vera Afreixo Isabelle Andre Marc Baguelin Ashutosh Agarwal R. David Andrew Timothy Bailey Ira Agrawal Steven Andrews Wyeth Bair Jacobo Aguirre Ioan Andricioaei Chris Bakal Alaa Ahmed Ioannis Androulakis Joseph Bak-Coleman Hasan Ahmed Iris Antes Adam Baker Natalie Ahn Maciek Antoniewicz Douglas Bakkum Thomas Akam Haroon Anwar Gabor Balazsi Ilya Akberdin Stefano Anzellotti Nilesh Banavali Eyal Akiva Miguel Aon Rahul Banerjee Sahar Akram Lucy Aplin Edward Banigan Tomas Alarcon Kevin Aquino Martin Banks Larissa Albantakis Leonardo Arbiza Mukul Bansal Reka Albert Murat Arcak Shweta Bansal Martí Aldea Gil Ariel Wolfgang Banzhaf Bree Aldridge Nimalan Arinaminpathy Lei Bao Helen Alexander Jeffrey Arle Gyorgy Barabas Alexander Alexeev Alain Arneodo Omri Barak Leonidas Alexopoulos Markus Arnoldini Matteo Barberis Emil Alexov -
1. Introduction
Reviews in Computational Biology 1. Introduction ! Christophe Dessimoz and James Smith January 2012 1 Today Course introduction Review writing 2 About Christophe • Diploma in Biology • PhD in Computer Science • Now: Visiting Scientist at EBI • Relevant experience: ~25 research articles ~50 peer-reviews for 14 journals ~15 funding proposals Guest editor of Briefings in Bioinformatics 3 - ETH Zurich, Northwestern, Tsinghua University, Chulalongkorn (Bangkok) About James • Biological Sciences & Pathway Biochemistry • PhD in Comp. Pharmacology (Drug Design) • Now: Scientist in Comp. Biochemistry • Previous experience: Research Fellow in Comp. Systems Biology ~20 research articles ~20 peer-reviews for 8 journals 12 funding proposals (myself & students) Experience as a technical editor 4 - BSc(Hons) Biological Sciences (Leicester) – halfway into a DPhil Biochemistry (Oxford) was lured to Pharmacology in Cambridge on an industrial scholarship, so jumped :-) – collaborations with universities/institutes in the USA, UK, Germany (inc EMBL), France and some pharmaceutical companies. What is doctoral training? • Mechanism for interdisciplinary research eg. at the interface between life and physical/computational sciences • CCBI http://en.wikipedia.org/wiki/Doctoral_Training_Centredoesn't have a DTC so we are piloting this course module 5 What is a Academic Training & Transferable Skills Course? Doctoral training has been around in diferent forms other European countries In the UK, doctoral training is a strategic mechanism for interdisciplinary research at the interface between the life and physical sciences or between disciplines DTC modules are conventionally for 1st/2nd years of a 3 or 4-year programme that augment the background of interdisciplinary projects and help researchers interact in new domains. They act as bridges between disciplines. -
Annual Scientific Report 2011 Annual Scientific Report 2011 Designed and Produced by Pickeringhutchins Ltd
European Bioinformatics Institute EMBL-EBI Annual Scientific Report 2011 Annual Scientific Report 2011 Designed and Produced by PickeringHutchins Ltd www.pickeringhutchins.com EMBL member states: Austria, Croatia, Denmark, Finland, France, Germany, Greece, Iceland, Ireland, Israel, Italy, Luxembourg, the Netherlands, Norway, Portugal, Spain, Sweden, Switzerland, United Kingdom. Associate member state: Australia EMBL-EBI is a part of the European Molecular Biology Laboratory (EMBL) EMBL-EBI EMBL-EBI EMBL-EBI EMBL-European Bioinformatics Institute Wellcome Trust Genome Campus, Hinxton Cambridge CB10 1SD United Kingdom Tel. +44 (0)1223 494 444, Fax +44 (0)1223 494 468 www.ebi.ac.uk EMBL Heidelberg Meyerhofstraße 1 69117 Heidelberg Germany Tel. +49 (0)6221 3870, Fax +49 (0)6221 387 8306 www.embl.org [email protected] EMBL Grenoble 6, rue Jules Horowitz, BP181 38042 Grenoble, Cedex 9 France Tel. +33 (0)476 20 7269, Fax +33 (0)476 20 2199 EMBL Hamburg c/o DESY Notkestraße 85 22603 Hamburg Germany Tel. +49 (0)4089 902 110, Fax +49 (0)4089 902 149 EMBL Monterotondo Adriano Buzzati-Traverso Campus Via Ramarini, 32 00015 Monterotondo (Rome) Italy Tel. +39 (0)6900 91402, Fax +39 (0)6900 91406 © 2012 EMBL-European Bioinformatics Institute All texts written by EBI-EMBL Group and Team Leaders. This publication was produced by the EBI’s Outreach and Training Programme. Contents Introduction Foreword 2 Major Achievements 2011 4 Services Rolf Apweiler and Ewan Birney: Protein and nucleotide data 10 Guy Cochrane: The European Nucleotide Archive 14 Paul Flicek: -
An Expanded Evaluation of Protein Function Prediction Methods Shows an Improvement in Accuracy
The University of Southern Mississippi The Aquila Digital Community Faculty Publications 9-7-2016 An Expanded Evaluation of Protein Function Prediction Methods Shows an Improvement In Accuracy Yuxiang Jiang Indiana University TFollowal Ronnen this and Or onadditional works at: https://aquila.usm.edu/fac_pubs Buck P arInstitutet of the forGenomics Research Commons On Agin Wyatt T. Clark RecommendedYale University Citation AsmaJiang, YR.., OrBankapuron, T. R., Clark, W. T., Bankapur, A. R., D'Andrea, D., Lepore, R., Funk, C. S., Kahanda, I., Verspoor, K. M., Ben-Hur, A., Koo, D. E., Penfold-Brown, D., Shasha, D., Youngs, N., Bonneau, R., Lin, A., Sahraeian, S. Miami University M., Martelli, P. L., Profiti, G., Casadio, R., Cao, R., Zhong, Z., Cheng, J., Altenhoff, A., Skunca, N., Dessimoz, DanielC., Dogan, D'Andr T., Hakala,ea K., Kaewphan, S., Mehryar, F., Salakoski, T., Ginter, F., Fang, H., Smithers, B., Oates, M., UnivGough,ersity J., ofTör Romeönen, P., Koskinen, P., Holm, L., Chen, C., Hsu, W., Bryson, K., Cozzetto, D., Minneci, F., Jones, D. T., Chapan, S., BKC, D., Khan, I. K., Kihara, D., Ofer, D., Rappoport, N., Stern, A., Cibrian-Uhalte, E., Denny, P., Foulger, R. E., Hieta, R., Legge, D., Lovering, R. C., Magrane, M., Melidoni, A. N., Mutowo-Meullenet, P., SeePichler next, K., page Shypitsyna, for additional A., Li, B.,authors Zakeri, P., ElShal, S., Tranchevent, L., Das, S., Dawson, N. L., Lee, D., Lees, J. G., Stilltoe, I., Bhat, P., Nepusz, T., Romero, A. E., Sasidharan, R., Yang, H., Paccanaro, A., Gillis, J., Sedeño- Cortés, A. E., Pavlidis, P., Feng, S., Cejuela, J. -
UCLA UCLA Electronic Theses and Dissertations
UCLA UCLA Electronic Theses and Dissertations Title Bipartite Network Community Detection: Development and Survey of Algorithmic and Stochastic Block Model Based Methods Permalink https://escholarship.org/uc/item/0tr9j01r Author Sun, Yidan Publication Date 2021 Peer reviewed|Thesis/dissertation eScholarship.org Powered by the California Digital Library University of California UNIVERSITY OF CALIFORNIA Los Angeles Bipartite Network Community Detection: Development and Survey of Algorithmic and Stochastic Block Model Based Methods A dissertation submitted in partial satisfaction of the requirements for the degree Doctor of Philosophy in Statistics by Yidan Sun 2021 © Copyright by Yidan Sun 2021 ABSTRACT OF THE DISSERTATION Bipartite Network Community Detection: Development and Survey of Algorithmic and Stochastic Block Model Based Methods by Yidan Sun Doctor of Philosophy in Statistics University of California, Los Angeles, 2021 Professor Jingyi Li, Chair In a bipartite network, nodes are divided into two types, and edges are only allowed to connect nodes of different types. Bipartite network clustering problems aim to identify node groups with more edges between themselves and fewer edges to the rest of the network. The approaches for community detection in the bipartite network can roughly be classified into algorithmic and model-based methods. The algorithmic methods solve the problem either by greedy searches in a heuristic way or optimizing based on some criteria over all possible partitions. The model-based methods fit a generative model to the observed data and study the model in a statistically principled way. In this dissertation, we mainly focus on bipartite clustering under two scenarios: incorporation of node covariates and detection of mixed membership communities. -
Ismb/Eccb 2019 Proceedings Papers Committee
Bioinformatics, 35, 2019, i3 doi: 10.1093/bioinformatics/btz494 ISMB/ECCB 2019 ISMB/ECCB 2019 PROCEEDINGS PAPERS COMMITTEE Downloaded from https://academic.oup.com/bioinformatics/article/35/14/i3/5529265 by guest on 04 October 2021 PROCEEDINGS COMMITTEE Systems Biology and Networks Sushmita Roy, University of Wisconsin, US PROCEEDINGS CO-CHAIRS Roded Sharan, Tel-Aviv University, Israel Yana Bromberg, Rutgers University, US General Computational Biology Nadia El-Mabrouk, Universite´ de Montre´al, Canada Olga Vitek, Northeastern University, US Predrag Radivojac, Northeastern University, US Daisuke Kihara, Purdue University, US Area Chairs: Bioinformatics Education Anne Rosenwald, Georgetown University, US Bioinformatics of Microbes and Microbiomes ISMB/ECCB 2019 STEERING COMMITTEE Curtis Huttenhower, Harvard University, US Yuzhen Ye, Indiana University, US Yana Bromberg, Proceedings Co-chair, Rutgers University, US Comparative and Functional Genomics Nadia El-Mabrouk, Proceedings Co-chair, Universite´deMontre´al, Can Alkan, Bilkent University, Turkey Canada Carl Kingsford, Carnegie Mellon University, US Bruno Gaeta, Treasurer, University of New South Wales, Australia Genome Privacy and Security Janet Kelso, Conference Advisory Council Co-chair, Max Planck Haixu Tang, Indiana University, US Institute for Evolutionary Anthropology, Germany Genomic Variation Analysis Diane E. Kovats, ISCB Executive Director, US Martin Kircher, Berlin Institute of Health, Germany Steven Leard, ISMB Conference Director, Canada Sriram Sankararaman, UCLA, US Thomas -
A Putative Origin of the Insect Chemosensory Receptor
SHORT REPORT A putative origin of the insect chemosensory receptor superfamily in the last common eukaryotic ancestor Richard Benton1*, Christophe Dessimoz1,2,3,4,5, David Moi1,2,3 1Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland; 2Department of Computational Biology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland; 3Swiss Institute of Bioinformatics, Lausanne, Switzerland; 4Department of Genetics, Evolution and Environment, University College London, London, United Kingdom; 5Department of Computer Science, University College London, London, United Kingdom Abstract The insect chemosensory repertoires of Odorant Receptors (ORs) and Gustatory Receptors (GRs) together represent one of the largest families of ligand-gated ion channels. Previous analyses have identified homologous ‘Gustatory Receptor-Like’ (GRL) proteins across Animalia, but the evolutionary origin of this novel class of ion channels is unknown. We describe a survey of unicellular eukaryotic genomes for GRLs, identifying several candidates in fungi, protists and algae that contain many structural features characteristic of animal GRLs. The existence of these proteins in unicellular eukaryotes, together with ab initio protein structure predictions, provide evidence for homology between GRLs and a family of uncharacterized plant proteins containing the DUF3537 domain. Together, our analyses suggest an origin of this protein superfamily in the last common eukaryotic ancestor. *For correspondence: [email protected] Introduction The insect chemosensory receptor superfamily, comprising Odorant Receptors (ORs) and Gustatory Competing interests: The Receptors (GRs), forms a critical molecular interface between diverse chemical signals in the environ- authors declare that no ment and neural activity patterns that evoke behavioral responses (Benton, 2015; Joseph and Carl- competing interests exist.