ISSN: 0258-851X

International Journal of Experimental and Clinical Pathophysiology and Drug Research

Volume 32 , Number 6, November-December 2018

Contents

Reviews

Treatment of Articular Cartilage Defects: Focus on Tissue Engineering. B. YLI SKA, P. SILMANOWICZ, A. SOBCZY SKA-RAK, . JAROSZ, T. SZPONDER (Lublin, PolandŻ) ...... Ń 1289 Ń Ł Can Complete Axillary Node Dissection Be Safely Omitted in Patients with Early Breast Cancer When the Sentinel Node Biopsy Is Positive for Malignancy? An Update for Clinical Practice. R. GERA, A. KASEM, K. MOKBEL (London, UK) ...... 1301

Experimental Studies

Cytotoxicity and Pro-/Anti-inflammatory Properties of Cinnamates, Acrylates and Methacrylates Against RAW264.7 Cells. Y. MURAKAMI, A. KAWATA, S. SUZUKI, S. FUJISAWA (Sakado, Japan) ...... 1309

Virome Analysis Reveals No Association of Head and Neck Vascular Anomalies with an Active Viral Infection. N. FRANKE, M. BETTE, A. MARQUARDT, T. BRIESE, W.I. LIPKIN, C. KURZ, J. EHRENREICH, E. MACK, B. BAYING, V. BENEŠ, F.R. RODEPETER, A. NEFF, A. TEYMOORTASH, B. EIVAZI, U. GEISTHOFF, B.A. STUCK, U. BAKOWSKY, R. MANDIC (Marburg; Heidelberg, Germany; New York City, NY, USA) ...... 1323

Expression of Circulating miR-155, miR-21, miR-221, miR-30a, miR-34a and miR-29a : Comparison of Colonic and Rectal Cancer. E. OROSZ, I. KISS, Z. GY NGYI, T. VARJAS (Budapest; P cs, Ö é Hungary) ...... 1333

Geranylgeraniol Induces PPAR γ Expression and Enhances the Biological Effects of a PPAR γ Agonist in Adipocyte Lineage Cells. T. MATSUBARA, N. TAKAKURA, M. URATA, Y. MURAMATSU, M. TSUBOI, K. YASUDA, W.N. ADDISON, M. ZHANG, K. MATSUO, C. NAKATOMI, Y. SHIGEYAMA-TADA, T. KANEUJI, A. NAKAMICHI, S. KOKABU (Kitakyushu; Miyazaki, Japan; Montreal, QC, Canada) ...... 1339

Contents continued on the back cover Contents continued The Neutrophil Response to Rabbit Antimicrobial Extract After Implantation of Biomaterial into a Bone/Cartilage Defect. T. SZPONDER, J. WESSELY-SZPONDER, A. SOBCZY SKA-RAK (Lublin, Poland) ...... Ń 1345

Blocking of Type 1 Angiotensin II Receptor Inhibits T-lymphocyte Activation and IL-2 Production. S. TAWINWUNG, N. PETPIROON, P. CHANVORACHOTE (Bangkok, Thailand) ...... 1353

Magnolol Induces Apoptosis and Inhibits ERK-modulated Metastatic Potential in Hepatocellular Carcinoma Cells. L.-Y. KUAN, W.-L. CHEN, J.-H. CHEN, F.-T. HSU, T.-T. LIU, W.-T. CHEN, K. WANG, W.-C. CHEN, Y.-C. LIU, W.-S. WANG (Taipei; Taichung; Yilan; Kaohsiung; Keelung; Chiayi; Changhua, Taiwan, ROC) ...... 1361

Feasibility and Characteristics of Pressurized Aerosol Chemotherapy (PAC) in the Bladder as a Therapeutical Option in Early-stage Urinary Bladder Cancer. A. MIKOLAJCZYK, V. KHOSRAWIPOUR, J. SCHUBERT, M. PLOCIENNIK, K. NOWAK, C. FAHR, H. CHAUDHRY, T. KHOSRAWIPOUR (Wroclaw, Poland; Dortmund; Freiburg; Duesseldorf, Germany; Irvine, CA, USA) ...... 1369

Banana Flower Extract Suppresses Benign Prostatic Hyperplasia by Regulating the Inflammatory Response and Inducing G 1 Cell-cycle Arrest. L.-C. LIU, Y.-H. LIN, Y.-C. LIN, C.-T. HO, C.-M. HUNG, T.-D. WAY, D.-T. BAU (Taichung; Taipei; Hualien; Kaohsiung, Taiwan, ROC; New Brunswick, NJ, USA) ...... 1373

How Much Ischemia Can the Severely Steatotic Rat Liver Tolerate? I.D. KOSTAKIS, N. SIKALIAS, K. ALEXIOU, L. MOUNTZALIA, A. PAPALOIS, T. KARATZAS (Athens; Pikermi, Greece) ...... 1381

The Involvement of Granulosa Cells in the Regulation by Gonadotropins of Cyp17a1 in Theca Cells. H. KAKUTA, T. IGUCHI, T. SATO (Yokohama, Japan) ...... 1387

Change in Amino Acid Pools During Neuronal Differentiation of PC12 Cells. A. SANO, H. SHI, R. SUZUKI, Y. SHIRATAKI, H. SAKAGAMI (Saitama, Japan; Shanghai, PR China) ...... 1403

Soluble Thrombomodulin Attenuates Endothelial Cell Damage in Hepatic Sinusoidal Obstruction Syndrome. S. TAKADA, T. MIYASHITA, Y. YAMAMOTO, S. KANOU, S. MUNESUE, Y. OHBATAKE, S. NAKANUMA, K. OKAMOTO, S. SAKAI, J. KINOSHITA, I. MAKINO, K. NAKAMURA, H. TAJIMA, H. TAKAMURA, I. NINOMIYA, S. FUSHIDA, T. OHTA (Kanazawa, Japan) ...... 1409

Evaluation of Porcine Hybrid Bone Block for Bone Grafting in Dentistry. S.E. KIM, E. LEE, K. JANG, K.M. SHIM, S.S. KANG (Gwangju, Republic of Korea) ...... 1419

Geranylgeraniol-induced Myogenic Differentiation of C2C12 Cells. T. MATSUBARA, M. URATA, T. NAKAJIMA, M. FUKUZAKI, R. MASUDA, Y. YOSHIMOTO, W.N. ADDISON, C. NAKATOMI, K. MORIKAWA, M. ZHANG, K. SAEKI, Y. TAKAHASHI, A. NAKAMICHI, S. KOKABU (Kitakyushu; Morioka, Japan; Montreal, QC, Canada) ...... 1427

Exercise Training Attenuates the Development of Cardiac Autonomic Dysfunction in Diabetic Rats. I. NAKOS, N.P.E. KADOGLOU, P. GKEKA, A.T. TZALLAS, N. GIANNAKEAS, D.G. TSALIKAKIS, M. KATSIMPOULAS, G. MANTZIARAS, N. KOSTOMITSOPOULOS, C.D. LIAPIS, J. KAKISIS (Athens; Arta; Kozani, Greece; London, UK) ...... 1433

Healing Effect of Platelet-rich Plasma on Decellularized Tracheal Allotransplantation in Rabbits. S.J. JANG, M.-H. PARK, T.-K. LEE, S.H. CHOI (Cheongju, Republic of Korea) ...... 1443

Contents continued on the preceding page Contents continued Application of Platelet-rich Plasma and Tricalcium Phosphate in the Treatment of Comminuted Fractures in Animals. T. SZPONDER, J. WESSELY-SZPONDER, A. SOBCZY SKA-RAK, B. YLI SKA, R.P. RADZKI, I. POLKOWSKA (Lublin, Poland) ...... Ń 1449 Ż Ń Clinical Studies

Impact of FDG-PET on the Detection of Patients with Lung Cancer at High Risk for ILD. P. FLECHSIG, O. HURAL, M. KREUTER, M. EICHHORN, G. HEU SS EL, C. SACHPEKIDIS, H.-U. KAUCZOR, U. HABERKORN, C.P. HEUSSEL, M. EICHINGER (Heidelberg, Germany) ...... 1457

Clinical and Radiological Mid- to Long-term Outcomes Following Ankle Fusion. I.E. GAEDKE, U. WIEBKING, P.F. O’LOUGHLIN, C. KRETTEK, R. GAULKE (Hannover, Germany; Cork, Ireland) .... 1463

Preliminary Report: Multiple Clusters of Proliferating Cells in Non-dysplastic Corrupted Colonic Crypts Underneath Conventional Adenomas. C.A. RUBIO (Stockholm, Sweden) ...... 1473

The Evolving Role of Pre-pectoral ADM-assisted Approach in Implant-based Immediate Breast Reconstruction Following Conservative Mastectomy: An Overview of the Literature and Description of Technique. U. WAZIR, K. MOKBEL (London, UK) ...... 1477

Potential Prognostic Factors of Downstaging Following Preoperative Chemoradiation for High Rectal Cancer. M. TREDER, R.P. VOGELSANG, S. JANSSEN, S.E. SCHILD, N.H. HOLL NDER, D. Ä RADES (L beck; Hannover, Germany; K ge; Naestved, Denmark; Scottsdale, AZ, USA) ...... 1481 ü ø Inverse Relationship Between Polio Incidence in the US and Colorectal Cancer. S. LEHRER, P.H. RHEINSTEIN (New York, NY; Severna Park, MD, USA) ...... 1485

Changes in HER2 Expression and Amplification Status Following Preoperative Chemotherapy for Gastric Cancer. S. SHU, M. IIMORI, R. NAKANISHI, T. JOGO, H. SAEKI, E. OKI, Y. MAEHARA (Fukuoka; Kamakura, Japan) ...... 1491

Correlation Between Dosimetric Parameters and Acute Dermatitis of Post-operative Radiotherapy in Breast Cancer Patients. T. TAKENAKA, H. YAMAZAKI, G. SUZUKI, N. AIBE, K. MASUI, D. SHIMIZU, T. NISHIMURA, A. NAKASHIMA, T. OGATA, K. MATSUSHITA, K. YOSHIDA, K. YAMADA (Kyoto; Osaka, Japan) ...... 1499

Histological Grade: Analysis of Prognosis of Non-small Cell Lung Cancer After Complete Resection. M. YASUKAWA, N. SAWABATA, T. KAWAGUCHI, N. KAWAI, T. NAKAI, C. OHBAYASHI, S. TANIGUCHI (Kashihara, Japan) ...... 1505

A Comparison of the Body Composition Changes Between Laparoscopy-assisted and Open Total Gastrectomy for Gastric Cancer. T. AOYAMA, T. YOSHIKAWA, Y. MAEZAWA, K. KANO, K. HARA, T. SATO, T. HAYASHI, T. YAMADA, H. CHO, T. OGATA, H. TAMAGAWA, N. YUKAWA, Y. RINO, M. MASUDA, T. OSHIMA (Kanagawa; Yokohama, Japan) ...... 1513

Spleen Dose–Volume Parameters as a Predictor of Treatment-related Lymphopenia During Definitive Chemoradiotherapy for Esophageal Cancer. T. SAITO, R. TOYA, N. YOSHIDA, T. SHONO, T. MATSUYAMA, S. NINOMURA, T. WATAKABE, Y. SASAKI, H. BABA, N. OYA (Kumamoto, Japan) ...... 1519

Contents continued on the preceding page Contents continued Impact of Ethnicity on Somatic Mutation Rates of Pancreatic Adenocarcinoma. N.S. AMARAL, V. RESENDE, J.S. DOS SANTOS, L.F. LIMA, D.C. MORAES, E. FRIEDMAN, L. DE MARCO, L. BASTOS-RODRIGUES (Belo Horizonte; Ribeir o Preto, Brazil; Tel-Hashomer, Israel) ...... 1527 ã CD44 Predicts Early Recurrence in Pancreatic Cancer Patients Undergoing Radical Surgery. C.-P. HSU, L.-Y. LEE, J.-T. HSU, Y.-P. HSU, Y.-T. WU, S.-Y. WANG, C.-N. YEH, T.-C. CHEN, T.-L. HWANG (Taoyuan, Taiwan, ROC) ...... 1533

Radiological Features of Programmed Cell Death-Ligand 2-positive Lung Adenocarcinoma: A Single- institution Retrospective Study. K. TAKADA, G. TOYOKAWA, K. AZUMA, S. TAKAMORI, T. JOGO, F. HIRAI, T. TAGAWA, A. KAWAHARA, J. AKIBA, I. OKAMOTO, Y. NAKANISHI, Y. ODA, T. HOSHINO, Y. MAEHARA (Fukuoka; Kurume, Japan) ...... 1541

PIVKA-II as a Potential New Biomarker for Hepatocellular Carcinoma – A Pilot Study. S. SVOBODOVA, M. KARLIKOVA, O. TOPOLCAN, L. PECEN, M. PESTOVA, O. KOTT, V. TRESKA, D. SLOUKA, R. KUCERA (Prague; Pilsen, Czech Republic) ...... 1551

Transcutaneous Carbon Dioxide Treatment Is Capable of Reducing Peripheral Vascular Resistance in Hypertensive Patients. B. N METH, I. KISS, B. AJTAY, I. P TER, Z. KRESKA, A. CZIR KI, I.G. É É Á HORV TH, Z. AJTAY (P cs; Hark ny, Hungary) ...... 1555 Á é á CD11c-Positive Dendritic Cells in Triple-negative Breast Cancer. H. LEE, H.J. LEE, I.H. SONG, W.S. BANG, S.-H. HEO, G. GONG, I.A. PARK (Seoul, Republic of Korea) ...... 1561

Prognostic Value of Thyroid Transcription Factor-1 Expression in Patients with Advanced Lung Adenocarcinoma. R. ZABLOCKIS, E. URAUSKAS, E. DANILA, V. GRUSLYS (Vilnius, Lithuania) ...... Ž 1571

Phase II Study of Weekly Amrubicin for Refractory or Relapsed Small Cell Lung Cancer. H. YOSHIOKA, Y. KOGURE, M. ANDO, C. KITAGAWA, M. IWASAKU, T. NIWA, H. SAKA (Kurashiki; Nagoya; Hirakata; Kyoto; Yokohama, Japan) ...... 1581

Efficacy of Ceritinib After Alectinib for ALK-positive Non-small Cell Lung Cancer. H. YOSHIDA, Y.H. KIM, H. OZASA, Y. SAKAMORI, T. TSUJI, T. NOMIZO, Y. YASUDA, T. YAMAMOTO, H. AJIMIZU, T. HIRAI (Kyoto, Japan) ...... 1587

Surgical Margin Status of Patients with Pancreatic Ductal Adenocarcinoma Undergoing Surgery with Radical Intent: Risk Factors for the Survival Impact of Positive Margins. C.-C. LAI, S.-Y. WANG, C.- H. LIAO, J.-T. HSU, K.-C. CHIANG, T.-S. YEH, T.-L. HWANG, C.-N. YEH (Taoyuan; Keelung, Taiwan, ROC) ...... 1591

The Assessment of Left Ventricle Function and Subclinical Atherosclerosis in Patients with Acute Myeloid Leukemia. A. MILITARU, A. AVRAM, A.M. CIMPEAN, M. IURCIUC, P. MATUSZ, D. LIGHEZAN, M. MILITARU (Timisoara, Romania) ...... 1599

Calcium Phosphate Cement Paste Injection as a Fiducial Marker of Cervical Cancer. I. OGINO, M. KITAGAWA, S. WATANABE, H. YOSHIDA, M. HATA (Yokohama, Japan) ...... 1609 mRCC Outcome in the Treatment of Metastatic Renal Cell Carcinoma – A German Single-center Real- world Experience. M. SCHWAB, R. HOFMANN, H. HEERS, A. HEGELE (Marburg, Germany) ...... 1617

Contents continued on the preceding page Contents continued Ischemic Damage Represents the Main Risk Factor for Biliary Stricture After Liver Transplantation: A Follow-Up Study in a Danish Population. B. LATTANZI, P. OTT, A. RASMUSSEN, K.R. KUDSK, M. MERLI, G.E. VILLADSEN (Rome, Italy; Aarhus; Copenhagen, Denmark) ...... 1623

Greek Version of the Connor-Davidson Resilience Scale: Psychometric Properties in a Sample of 546 Subjects. E. TSIGKAROPOULOU, A. DOUZENIS, N. TSITAS, P. FERENTINOS, I. LIAPPAS, I. MICHOPOULOS (Athens, Greece) ...... 1629

Hepatic Arterial Infusion Chemotherapy Is a Feasible Treatment Option for Breast Cancer with Liver- predominant Metastatic Disease. J.-H. HSIAO, H.-T. CHANG, Y.-D. TSENG, C.-L. CHIANG, I.-S. CHEN, Y.-C. CHEN, P.-M. CHANG, B.-W. WANG (Kaohsiung, Taiwan, ROC) ...... 1635

Safety and Efficacy of Trifluridine-Tipiracil Hydrochloride Oral Combination (TAS-102) in Patients with Unresectable Colorectal Cancer. S. NARIHIRO, K. SUWA, T. USHIGOME, M. OHTSU, S. RYU, Y. SHIMOYAMA, T. OKAMOTO, K. YANAGA (Tokyo, Japan) ...... 1643

Diagnostic Accuracy of Muscle Biopsy and Electromyography in 123 Patients with Neuromuscular Disorders. V.C. CONSTANTINIDES, M.M. PAPAHATZAKI, G.K. PAPADIMAS, N. KARANDREAS, T. ZAMBELIS, P. KOKOTIS, P. MANDA (Athens, Greece) ...... 1647

The Relationship Between Sepsis-induced Immunosuppression and Serum Toll-like Receptor 9 Level. N. ATALAN, L. ACAR, N. YAPICI, T. KUDSIOGLU, A. ERGEN, S.G. YILMAZ, T. ISBIR (Istanbul, Turkey) ...... 1653

Adjuvant Thalidomide and Metronomic Chemotherapy for the Treatment of Canine Malignant Mammary Gland Neoplasms. C.B. DE CAMPOS, G.E. LAVALLE, L.N. MONTEIRO, G.R.A. P GAS, Ê S.L. FIALHO, D. BALABRAM, G.D. CASSALI (Belo Horizonte; Jaboticabal; Vit ria, Brazil) ...... 1659 ó The Preoperative Geriatric Nutritional Risk Index Predicts Postoperative Complications in Elderly Patients with Gastric Cancer Undergoing Gastrectomy. S. KUSHIYAMA, K. SAKURAI, N. KUBO, Y. TAMAMORI, T. NISHII, A. TACHIMORI, T. INOUE, K. MAEDA (Osaka, Japan) ...... 1667

Index ...... 1673