ISSN: 0258-851X International Journal of Experimental and Clinical Pathophysiology and Drug Research Volume 32 , Number 6, November-December 2018 Contents Reviews Treatment of Articular Cartilage Defects: Focus on Tissue Engineering. B. YLI SKA, P. SILMANOWICZ, A. SOBCZY SKA-RAK, . JAROSZ, T. SZPONDER (Lublin, PolandŻ) .....................Ń 1289 Ń Ł Can Complete Axillary Node Dissection Be Safely Omitted in Patients with Early Breast Cancer When the Sentinel Node Biopsy Is Positive for Malignancy? An Update for Clinical Practice. R. GERA, A. KASEM, K. MOKBEL (London, UK) ...................................................................................................... 1301 Experimental Studies Cytotoxicity and Pro-/Anti-inflammatory Properties of Cinnamates, Acrylates and Methacrylates Against RAW264.7 Cells. Y. MURAKAMI, A. KAWATA, S. SUZUKI, S. FUJISAWA (Sakado, Japan) ................. 1309 Virome Analysis Reveals No Association of Head and Neck Vascular Anomalies with an Active Viral Infection. N. FRANKE, M. BETTE, A. MARQUARDT, T. BRIESE, W.I. LIPKIN, C. KURZ, J. EHRENREICH, E. MACK, B. BAYING, V. BENEŠ, F.R. RODEPETER, A. NEFF, A. TEYMOORTASH, B. EIVAZI, U. GEISTHOFF, B.A. STUCK, U. BAKOWSKY, R. MANDIC (Marburg; Heidelberg, Germany; New York City, NY, USA) ............................................................................................................................... 1323 Expression of Circulating miR-155, miR-21, miR-221, miR-30a, miR-34a and miR-29a : Comparison of Colonic and Rectal Cancer. E. OROSZ, I. KISS, Z. GY NGYI, T. VARJAS (Budapest; P cs, Ö é Hungary) ................................................................................................................................................. 1333 Geranylgeraniol Induces PPAR γ Expression and Enhances the Biological Effects of a PPAR γ Agonist in Adipocyte Lineage Cells. T. MATSUBARA, N. TAKAKURA, M. URATA, Y. MURAMATSU, M. TSUBOI, K. YASUDA, W.N. ADDISON, M. ZHANG, K. MATSUO, C. NAKATOMI, Y. SHIGEYAMA-TADA, T. KANEUJI, A. NAKAMICHI, S. KOKABU (Kitakyushu; Miyazaki, Japan; Montreal, QC, Canada) ............ 1339 Contents continued on the back cover Contents continued The Neutrophil Response to Rabbit Antimicrobial Extract After Implantation of Biomaterial into a Bone/Cartilage Defect. T. SZPONDER, J. WESSELY-SZPONDER, A. SOBCZY SKA-RAK (Lublin, Poland) ...................................................................................................................................................Ń 1345 Blocking of Type 1 Angiotensin II Receptor Inhibits T-lymphocyte Activation and IL-2 Production. S. TAWINWUNG, N. PETPIROON, P. CHANVORACHOTE (Bangkok, Thailand) .................................. 1353 Magnolol Induces Apoptosis and Inhibits ERK-modulated Metastatic Potential in Hepatocellular Carcinoma Cells. L.-Y. KUAN, W.-L. CHEN, J.-H. CHEN, F.-T. HSU, T.-T. LIU, W.-T. CHEN, K. WANG, W.-C. CHEN, Y.-C. LIU, W.-S. WANG (Taipei; Taichung; Yilan; Kaohsiung; Keelung; Chiayi; Changhua, Taiwan, ROC) ...................................................................................................................... 1361 Feasibility and Characteristics of Pressurized Aerosol Chemotherapy (PAC) in the Bladder as a Therapeutical Option in Early-stage Urinary Bladder Cancer. A. MIKOLAJCZYK, V. KHOSRAWIPOUR, J. SCHUBERT, M. PLOCIENNIK, K. NOWAK, C. FAHR, H. CHAUDHRY, T. KHOSRAWIPOUR (Wroclaw, Poland; Dortmund; Freiburg; Duesseldorf, Germany; Irvine, CA, USA) .................................. 1369 Banana Flower Extract Suppresses Benign Prostatic Hyperplasia by Regulating the Inflammatory Response and Inducing G 1 Cell-cycle Arrest. L.-C. LIU, Y.-H. LIN, Y.-C. LIN, C.-T. HO, C.-M. HUNG, T.-D. WAY, D.-T. BAU (Taichung; Taipei; Hualien; Kaohsiung, Taiwan, ROC; New Brunswick, NJ, USA) .................. 1373 How Much Ischemia Can the Severely Steatotic Rat Liver Tolerate? I.D. KOSTAKIS, N. SIKALIAS, K. ALEXIOU, L. MOUNTZALIA, A. PAPALOIS, T. KARATZAS (Athens; Pikermi, Greece) ................. 1381 The Involvement of Granulosa Cells in the Regulation by Gonadotropins of Cyp17a1 in Theca Cells. H. KAKUTA, T. IGUCHI, T. SATO (Yokohama, Japan) ....................................................................... 1387 Change in Amino Acid Pools During Neuronal Differentiation of PC12 Cells. A. SANO, H. SHI, R. SUZUKI, Y. SHIRATAKI, H. SAKAGAMI (Saitama, Japan; Shanghai, PR China) ................................ 1403 Soluble Thrombomodulin Attenuates Endothelial Cell Damage in Hepatic Sinusoidal Obstruction Syndrome. S. TAKADA, T. MIYASHITA, Y. YAMAMOTO, S. KANOU, S. MUNESUE, Y. OHBATAKE, S. NAKANUMA, K. OKAMOTO, S. SAKAI, J. KINOSHITA, I. MAKINO, K. NAKAMURA, H. TAJIMA, H. TAKAMURA, I. NINOMIYA, S. FUSHIDA, T. OHTA (Kanazawa, Japan) ........................................ 1409 Evaluation of Porcine Hybrid Bone Block for Bone Grafting in Dentistry. S.E. KIM, E. LEE, K. JANG, K.M. SHIM, S.S. KANG (Gwangju, Republic of Korea) ......................................................................... 1419 Geranylgeraniol-induced Myogenic Differentiation of C2C12 Cells. T. MATSUBARA, M. URATA, T. NAKAJIMA, M. FUKUZAKI, R. MASUDA, Y. YOSHIMOTO, W.N. ADDISON, C. NAKATOMI, K. MORIKAWA, M. ZHANG, K. SAEKI, Y. TAKAHASHI, A. NAKAMICHI, S. KOKABU (Kitakyushu; Morioka, Japan; Montreal, QC, Canada) ............................................................................................... 1427 Exercise Training Attenuates the Development of Cardiac Autonomic Dysfunction in Diabetic Rats. I. NAKOS, N.P.E. KADOGLOU, P. GKEKA, A.T. TZALLAS, N. GIANNAKEAS, D.G. TSALIKAKIS, M. KATSIMPOULAS, G. MANTZIARAS, N. KOSTOMITSOPOULOS, C.D. LIAPIS, J. KAKISIS (Athens; Arta; Kozani, Greece; London, UK) ....................................................................................................... 1433 Healing Effect of Platelet-rich Plasma on Decellularized Tracheal Allotransplantation in Rabbits. S.J. JANG, M.-H. PARK, T.-K. LEE, S.H. CHOI (Cheongju, Republic of Korea) ........................................ 1443 Contents continued on the preceding page Contents continued Application of Platelet-rich Plasma and Tricalcium Phosphate in the Treatment of Comminuted Fractures in Animals. T. SZPONDER, J. WESSELY-SZPONDER, A. SOBCZY SKA-RAK, B. YLI SKA, R.P. RADZKI, I. POLKOWSKA (Lublin, Poland) ................................................................Ń 1449 Ż Ń Clinical Studies Impact of FDG-PET on the Detection of Patients with Lung Cancer at High Risk for ILD. P. FLECHSIG, O. HURAL, M. KREUTER, M. EICHHORN, G. HEU SS EL, C. SACHPEKIDIS, H.-U. KAUCZOR, U. HABERKORN, C.P. HEUSSEL, M. EICHINGER (Heidelberg, Germany) .................... 1457 Clinical and Radiological Mid- to Long-term Outcomes Following Ankle Fusion. I.E. GAEDKE, U. WIEBKING, P.F. O’LOUGHLIN, C. KRETTEK, R. GAULKE (Hannover, Germany; Cork, Ireland) .... 1463 Preliminary Report: Multiple Clusters of Proliferating Cells in Non-dysplastic Corrupted Colonic Crypts Underneath Conventional Adenomas. C.A. RUBIO (Stockholm, Sweden) ........................................... 1473 The Evolving Role of Pre-pectoral ADM-assisted Approach in Implant-based Immediate Breast Reconstruction Following Conservative Mastectomy: An Overview of the Literature and Description of Technique. U. WAZIR, K. MOKBEL (London, UK) ............................................................................... 1477 Potential Prognostic Factors of Downstaging Following Preoperative Chemoradiation for High Rectal Cancer. M. TREDER, R.P. VOGELSANG, S. JANSSEN, S.E. SCHILD, N.H. HOLL NDER, D. Ä RADES (L beck; Hannover, Germany; K ge; Naestved, Denmark; Scottsdale, AZ, USA) ................... 1481 ü ø Inverse Relationship Between Polio Incidence in the US and Colorectal Cancer. S. LEHRER, P.H. RHEINSTEIN (New York, NY; Severna Park, MD, USA) ...................................................................... 1485 Changes in HER2 Expression and Amplification Status Following Preoperative Chemotherapy for Gastric Cancer. S. SHU, M. IIMORI, R. NAKANISHI, T. JOGO, H. SAEKI, E. OKI, Y. MAEHARA (Fukuoka; Kamakura, Japan) ................................................................................................................. 1491 Correlation Between Dosimetric Parameters and Acute Dermatitis of Post-operative Radiotherapy in Breast Cancer Patients. T. TAKENAKA, H. YAMAZAKI, G. SUZUKI, N. AIBE, K. MASUI, D. SHIMIZU, T. NISHIMURA, A. NAKASHIMA, T. OGATA, K. MATSUSHITA, K. YOSHIDA, K. YAMADA (Kyoto; Osaka, Japan) ......................................................................................................................................... 1499 Histological Grade: Analysis of Prognosis of Non-small Cell Lung Cancer After Complete Resection. M. YASUKAWA, N. SAWABATA, T. KAWAGUCHI, N. KAWAI, T. NAKAI, C. OHBAYASHI, S. TANIGUCHI (Kashihara, Japan) ............................................................................................................ 1505 A Comparison of the Body Composition Changes Between Laparoscopy-assisted and Open Total Gastrectomy for Gastric Cancer. T. AOYAMA, T. YOSHIKAWA, Y. MAEZAWA, K. KANO, K. HARA, T. SATO, T. HAYASHI, T. YAMADA, H. CHO, T. OGATA, H. TAMAGAWA, N. YUKAWA, Y. RINO, M. MASUDA, T. OSHIMA (Kanagawa; Yokohama, Japan) .................................................................. 1513 Spleen Dose–Volume Parameters as a Predictor of Treatment-related Lymphopenia During Definitive Chemoradiotherapy for Esophageal Cancer. T. SAITO, R. TOYA, N. YOSHIDA, T. SHONO, T. MATSUYAMA,