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The Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla, CA 92037 Infectiology Models Vaccine Monoclonal antibodies New Therapeutic Antimicrobial & Vaccine Approaches in THE BOOK Infectious Diseases nd April 2 2008 The Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla, CA 92037 French American Biotechnology Symposium French BIO Beach Antimicrobial Welcome to the FABS, French American Biotech Symposium, on “New Therapeutic & Vaccine Approaches in Infectious Diseases”, held on April 2nd 2008, at The Salk Institute for Biological Studies! The French American Biotech Symposium is launched by the Office for Science and Technology of the Embassy of France, aiming to be held yearly in California. reambule P The FABS event aims to : • Promote research and innovation where California and France share a competitive advantage • Foster French-Californian cooperation between research laboratories and biotech companies • Favor the emergence of collaborative and innovative research projects. In 2008, the symposium is focused on the New therapeutic and Vaccine Approaches in Infectious Diseases. Four sessions will cover the key issues for vaccine development, the future of therapeutic monoclonal antibodies, the advances of humanized animal models and the new perspectives for antimicrobial treatments. Each session will propose French & American presentations followed by a round table with the participants. The symposium is organized by Lyonbiopole (Rhône-Alpes, France) and The Office for Science and Technology of the Embassy of France in Los Angeles, in partnership with The Salk Institute for Biological Studies (La Jolla, CA) and French BIO Beach (La Jolla, CA) and with the presence of the French Bio Competitiveness Clusters, Alsace Biovalley (Alsace), Cancer-Bio-Health Cluster (Toulouse), Orpheme (LR-PACA) and Medicen Paris Region. The event benefits from the support of the French Ministry of Economy, Finance and Employment (DGE). Targeted attendees are French and American scientists and biotech entrepreneurs. Networking opportunities will be offered for them during the event and the day after during the French American Bio Biz, FABZ April 3rd 2008, a business event focused on new ways to improve IP portofolio for US and French based firms. Now let’s start ... PrOGram “NEW THERAPEU T IC A N D VACCI N E APPROACHES IN IN FEC T IOUS DISEASES ” Antimicrobial at The Salk Institute for Biological Studies 8.00 am ..............................Registration Opening Jacques Descotes, M.D., Pharm.D., Ph.D., Professor, Claude Bernard University and Head, Lyon Poison Center 8.30 to 9.00 am ................Welcome Talks Title: Immunotoxicity evaluation of monoclonal antibodies: from Roger Guillemin, Distinguished Professor, Nobel Prize of Medicine, animal to man President by interim of The Salk Institute for Biological Studie Philippe Larrieu, Consul General of France in Los Angeles 1.00 to 2.30 pm .................Lunch – Posters Sessions 9.00 to 10.30 am ...............Session 1: 2.30 to 4.00 pm .................Session 3: 1 Key Issues for Vaccine Development – Part I 3 Towards Humanized Animal Models Chairman : Jean-Yves Bonnefoy, Ph.D., VP, R&D, Transgene Chaiman: James P. Di Santo, M.D., Ph.D., Professor of Immunology, Institut Pasteur Keynote Speaker : Jacques Banchereau, Ph.D., Director, Baylor Institute for Immunology Research, Director, INSERM-U899, BIIR/ANRS/ Amine Abina, M.D., Ph.D., President & CEO, Nokad INSERM Center for Human Vaccines Title: Protein-functional-Knock-Out: a new approach in target Title: Humanized mice to understand the pathophysiology of human validation and models of pathology dendritic cells in vivo Jérôme Tiollier, Ph.D., EVP Development & Operations, Innate Pharma Greg Lemke, Professor & Director, Molecular Neurobiology Laboratory, Title: Limist & Merits of preclinical pharmacological assessment of The Salk Institute for Biological Studies immunotherapeutic drugs during development Title: New Adjuvant Approaches Kader Thiam, Ph.D., VP Transgenic Technologies, genOway Anette Schneemann, Ph.D., Associate Professor, Department Molecular Title: Use of genetically modified animal models aiming at increasing Biology, The Scripps Research Institute the predictability and the throughput of immune response analysis Title: Virus-like particles as platforms for vaccine development in vivo Alain Rolland, Pharm.D., Ph.D., Senior Vice President, Product Develop- Erwan Corcuff, Axenis Project Leader, Technical Coordinator of ment and Corporate Officer, Vical Inc. « Human Vaccine Consortium» and Medicen/Modexa/Biotherapies, Title: DNA Vaccines : the end of the beginning Cytokines & Lymphoïd Development, Institut Pasteur Title: Novel humanized mouse model for Testing HIV and HCV Vaccine 10.30 to 10.45 am .............Coffee break Candidates 10.45 to 12.00 am .............Session 1: 4.00 to 4.15 pm .................Coffee break 1 Key Issues for Vaccine Development – Part II Chairman: Jean-Yves Bonnefoy, Ph.D., VP, R&D, Transgene 4.15 to 5.45 pm .................Session 4: 4 New Perspectives for Antimicrobial Treatments Marie Louise Michel, Ph.D., Department of Virology, Institut Pasteur, Chairman: John A. T. Young, Ph.D., Professor and faculty Director of Pathogenesis of hepatitis B virus laboratory Chair, The Salk Institute for Biological Studies Title: Therapeutic vaccination for chronic infection Keynote Speaker: Jean-Pierre Gorvel, Ph.D., Director of the Centre Phil Felgner, Professor, University of California at Irvine d’Immunologie de Marseille-Luminy, Executive Director of the Title: Profiling the Immune Response to Infections with Genome-Wide Foundation FINOVI, Innovation in Infectiology Proteome Arrays Title: Dr. Jekyll and Mr Hide : virulence factors as new antimicrobials Philip R. Dormitzer, M.D., Ph.D., Sr. Director, Viral Vaccine Research, Erica Ollmann Saphire, Ph.D., Assistant Professor, Department of Novartis Vaccines and Diagnostics Immunology, The Scripps Research Institute Title: Structure based vaccine design Title: Crystal Structure of the Trimeric, Prefusion Ebola Virus Glycopro- tein in Complex with a Neutralizing Antibody from a Human Survivor 12.00 to 1.00 pm ...............Session 2: 2 The Future of Therapeutic Monoclonals Antibodies Sonia Escaich, Ph.D., Vice-President, Chief Scientific Officer, Mutabilis SA Chairman: Shane Crotty, Ph.D., Assistant Professor, Division Title: New antibacterial approaches using new targets of Vaccine Discovery, La Jolla Institute for Allergy and Immunology Ludovic Tailleux, Ph.D., Mycobacterial Genetic Unit, Institut Pasteur Title: Challenges in Tuberculosis Therapies Ava Song, Ph.D., Scientist and Project Leader, Kirin Pharma USA, Inc., Shinichiro Kato, PhD, President and CSO, Kirin Pharma USA, Inc. 5.45 to 6.15 pm .................Closing Session Title: A fully human monoclonal antibody targeting influenza A virus M2 protein: Novel therapeutics for flu 6.15 to 7.00 pm .................. Cocktail and Posters sessions NTS p.6 Part 1 ..... Talk Abstracts e p.54 Part 2 ..... Poster Abstracts OF CONT able p.62 Part 3 ..... French Bio Competitiveness T Cluster Partners Presentations p.74 Part 4 ..... Partner Presentations p.80 Part 5 ..... Contacts Infectiology Antimicrobial Part Part 1 Part 1 • Talk Abstracts 6 Part 1 • Talk Abstracts 7 Notes Welcome Talks Pr. Roger Guillemin Distinguished Professor, Nobel Prize of Medecine President by interim of The Salk Institute for Biological studies, La Jolla, CA, USA bstracts bstracts a Roger Guillemin, born in Dijon, France,1924. M.D. Faculty of Medicine, Lyon, 1949, Ph.D., University of Montreal, 1952. Professor of Physiology, Baylor College of Medicine, Houston, Texas 1953-1970. Founding Director, Laboratories for Neuroendocrinology, The Salk Institute, La Jolla CA, 1970-1990, Distinguished Professor, The Salk Institute, current. Numerous degrees honoris causa. National Academy of Sciences, Washington, D.C., Académie des Sciences, Paris, Académie nationale de Médecine, Paris. National Medal of Sciences, USA, 1976. Nobel Prize in Physiology & Medicine, 1977. Officer, Légion d’Honneur, 1984. Since October 1st., 2007, Part 1 : Talk 1 : Talk Part interim President, The Salk Institute. 8 Notes Welcome Talks Philippe Larrieu Consul General of France in Los Angeles, USA Born on October 27, 1953, Mr. Philippe Larrieu holds a law degree and is a gradutated of the Institut d’Etudes Politiques and the Ecole Nationale d’Administration (the school for future leaders in the French civil service). A career diplomat, Mr. Larrieu joined the French Ministry of Foreign Affairs on June 1, 1980 and served as First Secretary at the French Embassy in Brasilia until 1982. He was then assigned to Djeddah, Saudi Arabia, as Counsellor for Development and Cultural Cooperation. In 1985, he returned to the Ministry’s headquarters and was appointed to the Department for Cooperation, Cultural, Scientific and Technological Relations. From 1987 to 1989, he served at the French Embassy in Singapore as Deputy Head of Mission, prior to becoming Under-Secretary for North Africa at the Ministry of Foreign Affairs. Subsequently, Mr. Larrieu held the position of Counsellor at the French Embassy in Ankara (1992-1993) and at the French Embassy in Warsaw (1994-1998). He was Consul General of France in Algiers from 1998 until 2002 when he was assigned to the Inspection Corps of the Ministry. In September 2004, he took up his current post of Consul General of France in Los Angeles, with jurisdiction over Southern California, Arizona, Colorado, New Mexico and Southern Nevada. A knight in the French National Order of
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