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IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 13/01/2016 1 Sour

Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year 8.2 Eye Irritation Becker J., Parke G. St. Effects on eye mucosa - albinos Rabbits M51-75, SE-6590 0 7758-29-4 1975 C1 Cannon (for Mobil) STPP E. rabbits 8.1 Skin irritation Becker J., Parke G. St. E In vivo skin irritation - rabbits Rabbits M52-75, SE-6600 0 7758-29-4 1975 C2 Cannon (for Mobil) STPP 9.1.1 Short term toxicity testing on invertebrates Vaishnav D.D., Yurk Acute toxicity - Daphnia Daphnia FMC I89-1084 0 7758-29-4 1990 F01 ESE Gainsville STPP J.J., Ives, Wade B.A. 8.2 Eye Irritation W. Barta, T. Cascieri, Preliminary eye irritation - rabbits Rabbits FMC I86-917 0 7758-29-4 1986 F02 FMC Tox Lab STPP 8.1 Skin irritation Freeman C In vivo skin irritation - rabbits Rabbits I88-1047 0 7758-29-4 1989 F03 FMC Tox Lab STPP 8.5.1 Acute oral toxicity Watt B Acute oral toxicity - Rats Rats I97-2169 0 7758-29-4 1997 F04 FMC Tox Lab STPP 8.5.2 Acute inhalation toxicity Jackson G.C., Hardy Acute inhalation toxicity - Rats Rats I88-1011 0 7758-29-4 1989 F05 FMC Tox Lab STPP C.J., Chanter D.O. 8.1 Skin irritation Dr. Weigand M. “Natriumtripolyphosphat Rats 1966.0093 0 7758-29-4 1966 H1 Fabwerke Hoechst STPP toxikologische prüfung” - Skin and 8.2 Eye Irritation Dr. Weigand M. “Natriumtripolyphosphat Rats 1966.0093 0 7758-29-4 1966 H1 Fabwerke Hoechst STPP toxikologische prüfung” - Skin and 9.1.2 Growth inhibition study in aquatic plants Herschke B., Cellier "Ecotoxicilogie du tripolyphosphate algae (fresh and 614-9240 0 7758-29-4 1985 R1 Rhône Poulenc R Decines STPP …" - Toxicity algae (fresh and sea sea water) 9.1.1 Short term toxicity testing on invertebrates Dion M "Etude de la toxicité aquatique …" - Daphnia 614.9246 0 7758-29-4 1985 R2 Rhône Poulenc R Decines STPP Acute toxicity daphnia and zebra fish STPP 0 7758-29-4 9.1.3 Short-term toxicity testing on fish Dion M 1985 None - Acute toxicity to zebra fish Zebra fish R2 Rhône Poulenc R Decines 614.9246 STPP 0 7758-29-4 8.1 Skin irritation Kamienski F. X., C.H. 1971 Acute oral (rat) and dermal toxicity, Rats & Rabbits S1 Stauffer Western RC T-1713 STPP 0 7758-29-4 8.5.1 Acute oral toxicity Kamienski F. X., C.H. 1971 Acute oral (rat) and dermal toxicity, Rats & Rabbits S1 Stauffer Western RC T-1713 8.5.3 Acute dermal toxicity Kamienski F. X., C.H. Acute oral (rat) and dermal toxicity, Rats & Rabbits T-1713 0 7758-29-4 1971 S1 Stauffer Western RC STPP Bullock skin and eye irritation (all rabbit) 8.1 Skin irritation Younger F.M. In vivo skin irritation - rabbits Rabbits Y-62-71 0 7758-29-4 1962 BK31 Younger Lab STPP 8.2 Eye Irritation Younger F.M. Eye irritation rabbits Rabbits Y-62-71 0 7758-29-4 1962 BK31 Younger Lab STPP STPP 0 7758-29-4 8.5.1 Acute oral toxicity Birch M.D. 1976 acute oral toxicity – Rats Rats BK32 Younger Lab Y-76-234 STPP 0 7758-29-4 8.5.1 Acute oral toxicity Birch M.D. 1976 acute oral toxicity – Rats Rats BK32 Younger Lab Y-76-234 Sodium tripolyphosphate hexaydrate 0 7758-29-4 9.2.2.1 Hydrolysis as a function of pH Gaillot J.C. 1985 etude des especes phosphatees en water R3 0 448-6402 sodium tripolyphosphate 0 7758-29-4 8.6.1 Short-term repeated dose toxicity Hodge C.H. 1956 pilot toxicity test Rats H1 Uni Rochester 0 sodium tripolyphosphate 0 7758-29-4 8.6.1 Short-term repeated dose toxicity Hodge C.H. 1956 pilot toxicity test Dogs H1 Uni Rochester 0 sodium tripolyphosphate 0 7758-29-4 8.6.3 Long term repeated dose toxicity study Hodge C.H. 1959 chronic oral toxicity studies in rats Rats H2 Uni Rochester 0 sodium tripolyphosphate 0 7758-29-4 8.7.3 Two generation reproductive toxicity study Hodge C.H. 1959 chronic oral toxicity studies in rats Rats H2 Uni Rochester 0 sodium tripolyphosphate 0 7758-29-4 8.9.1 Carcinogenicity Hodge C.H. 1959 chronic oral toxicity studies in rats Rats H2 Uni Rochester 0 sodium tripolyphosphate 0 7758-29-4 9.1.1 Short term toxicity testing on invertebrates Pandard 2004 Inhibition of the mobility of Daphnia Daphnia I1 Ineris 50840a sodium tripolyphosphate 0 7758-29-4 9.1.1 Short term toxicity testing on invertebrates Pandard 2004 Inhibition of the mobility of Ceriodaphnia I2 Ineris 50840b sodium tripolyphosphate 0 7758-29-4 8.3 Skin sensitisation Bradshaw J. 2008 OECD 429 - LLNA mouse STPP LLNA safepharm 2532/0002 sodium tripolyphosphate 0 7758-29-4 7.4 Relative Density Woolley A.j., Woolley 2008 OECD 109 - Relative density material itself STPP density safepharm 2532/0001 sodium tripolyphosphate 0 7758-29-4 8.3 Skin sensitisation P&G 1999 Buehler study Guinea pigs P&G P&G unpublished data sodium tripolyphosphate 0 7758-29-4 8.1 Skin irritation Becker J and Parke G 1975 A primary dermal irritation study of rabbit PS-3783 Cannon (for Mobil) lab no. 7E-6600 sodium tripolyphosphate 0 7758-29-4 8.2 Eye Irritation Becker J and Parke G 1975 The effects of MCTR-5-75 on the eye rabbit PS-3784 Cannon (for Mobil) lab no. 7E-6599 STPP 0 7758-29-4 9.1.3 Short-term toxicity testing on fish ? ? No data - Short-term toxicity to fish Fish - bluegill P&G ? P&G internal ref: 15546 STPP 0 7758-29-4 8.1 Skin irritation ? ? Skin irritation rabbit P&G ? 16927 STPP 0 7758-29-4 8.1 Skin irritation ? ? Skin irritation rabbit P&G ? 10539 STPP 0 7758-29-4 8.1 Skin irritation ? ? Skin irritation rabbit P&G ? 10120 STPP 0 7758-29-4 8.2 Eye Irritation ? ? Eye irritation rabbits rabbit P&G ? 16769 STPP 0 7758-29-4 8.2 Eye Irritation ? ? Eye irritation rabbits rabbit P&G ? 13185 STPP 0 7758-29-4 8.3 Skin sensitisation ? ? Clinical sensitisation Human P&G ? 5097 STPP 0 7758-29-4 8.3 Skin sensitisation ? ? Clinical sensitisation Human P&G ? 5088

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 13/01/2016 2 Sour

Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year STPP 0 7758-29-4 8.3 Skin sensitisation ? ? Clinical sensitisation Human P&G ? 5087 STPP 0 7758-29-4 8.3 Skin sensitisation ? ? Clinical sensitisation Human P&G ? 5083 STPP 0 7758-29-4 8.3 Skin sensitisation ? ? Clinical sensitisation Human P&G ? 5082 STPP 0 7758-29-4 8.3 Skin sensitisation ? ? Clinical sensitisation Human P&G ? 5061 8.3 Skin sensitisation ? Clinical sensitisation Human 2819 0 7758-29-4 ? P&G ? STPP 8.3 Skin sensitisation ? Clinical sensitisation Human 1213 0 7758-29-4 ? P&G ? STPP 8.3 Skin sensitisation ? Clinical sensitisation Human 409 0 7758-29-4 ? P&G ? STPP 8.5.1 Acute oral toxicity ? Acute toxicity rat 18322 0 7758-29-4 ? P&G ? STPP 8.5.1 Acute oral toxicity ? Acute toxicity rat 13611 0 7758-29-4 ? P&G ? STPP 8.5.1 Acute oral toxicity ? Acute toxicity mice 36318 0 7758-29-4 ? P&G ? STPP 8.5.1 Acute oral toxicity ? Acute toxicity rat 10842 0 7758-29-4 ? P&G ? STPP 8.5.1 Acute oral toxicity ? Acute toxicity mice 3310 0 7758-29-4 ? P&G ? STPP STPP 0 7758-29-4 8.6.1 Short-term repeated dose toxicity ? ? Short-term repeated dose, oral, 28- rat P&G ? 12207 STPP 0 7758-29-4 8.6.2 Subchronic toxicity study ? ? Subchronic toxicity rat P&G ? 103 STPP 0 7758-29-4 8.6.2 Subchronic toxicity study ? ? Subchronic toxicity rat P&G ? 102 STPP 0 7758-29-4 8.6.2 Subchronic toxicity study ? ? Subchronic toxicity rat P&G ? 101 8.6.1 Short-term repeated dose toxicity ? Short-term repeated dose rat, Guinea pig, 8689 0 7758-29-4 ? Monkey P&G ? STPP 8.6.1 Short-term repeated dose toxicity ? Short-term repeated dose, oral, 28- Rat 2813 0 7758-29-4 ? day P&G ? STPP 8.9.1 Carcinogenicity ? Carcinogenicity RABBITS- New 7336 0 7758-29-4 ? Zealand White P&G ? STPP Male Rabbits 8.9.1 Carcinogenicity ? Carcinogenicity MICE- Albino 6950 0 7758-29-4 ? COX ICR Female P&G ? STPP Mice 7.7 Water Fox J A6 Water Solubility N/A 0 7758-29-4 2009 STPP Consortium Harlan STPP STPP 0 7758-29-4 8.2 Eye Irritation Durando J 2011 Eye irritation in vivo Rabbit ICLPP Eurofins 31320 8.2 Eye Irritation Durando J OECD 405 Rabbit 31320 0 7758-29-4 2011 ICLPP_STPP Eurofins Sodium tripolyphosphate Mono-sodium phosphate 2 7558-80-7 8.2 Eye Irritation Freeman C 1987 Eye irritation rabbits Rabbits F15 FMC I 86-0923 Mono-sodium phosphate 2 7558-80-7 8.1 Skin irritation Freeman C 1990 In vivo skin irritation - rabbits Rabbits F29 FMC I 90-1132 Mono-sodium phosphate 2 7558-80-7 8.5.2 Acute inhalation toxicity Signorin J. 1993 Acute inhalation toxicity rats Rats F33 FMC I 93-1754

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 13/01/2016 3 Sour

Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year 8.5.1 Acute oral toxicity Birch M.D. single oral dose Rats Y-73-75 2 7558-80-7 1973 BK16 Younger Lab monosodium phosphate monosodium phosphate 2 7558-80-7 8.5.3 Acute dermal toxicity Birch M.D. 1973 acute skin absorption minimal lethal Rabbits BK16 Younger Lab Y-73-75 monosodium phosphate 2 7558-80-7 8.1 Skin irritation Birch M.D. 1973 In vivo skin irritation - rabbits Rabbits BK16 Younger Lab Y-73-75 monosodium phosphate 2 7558-80-7 8.2 Eye Irritation Birch M.D. 1973 Eye irritation rabbits Rabbits BK16 Younger Lab Y-73-75 9.2.2.1 Hydrolysis as a function of pH Gaillot J.C. etude des especes phosphatees en water 448-6402 2 7558-80-7 1985 R3 Monosodium orthophosphate sortie de machine a laver monosodium phosphate 2 7558-80-7 8.5.1 Acute oral toxicity Bullock CH and 1972 Toxicology lab report rat PS-2865 Stauffer Western RC T-4054 monosodium phosphate 2 7558-80-7 8.1 Skin irritation Bullock CH and 1972 In vivo skin irritation - rabbits rabbit PS-2860 Stauffer Western RC T-1861 Sodium dihydrogenorthophosphate 2 7558-80-7 7.7 Water solubility Walker J 2009 A6 Water Solubility N/A IP Consortium Harlan 2920/0001 7.2 Melting/freezing point Walker J Melting point N/A 2920/0001 2 7558-80-7 2009 IP Consortium Harlan Sodium dihydrogenorthophosphate Sodium dihydrogenorthophosphate 2 7558-80-7 8.3 Skin sensitisation Bradshaw J 2009 OECD 429 - LLNA Mouse IP Consortium Harlan 2920/0003 Sodium dihydrogenorthophosphate 2 7558-80-7 8.5.1 Acute oral toxicity Bradshaw J 2009 OECD 420 - Acute oral toxicity Rat IP Consortium Harlan 2920/0002 Sodium dihydrogenorthophosphate 2 7558-80-7 7.4 Relative Density Woolley A 2010 OECD 109 - Relative density N/A IP Consortium Harlan 2920/0098 8.2 Eye Irritation Freeman C Eye irritation rabbits Rabbits I 86-0931 3 7558-79-4 1987 F22 FMC Di-sodium phosphate 8.1 Skin irritation Birch M.D. In vivo skin irritation - rabbits Rabbits Y-72-193 3 7558-79-4 1972 BK14 Younger Lab disodium phosphate disodium phosphate 3 7558-79-4 8.5.1 Acute oral toxicity Birch M.D. 1973 single oral dose Rats BK15 Younger Lab Y-73-85 disodium phosphate 3 7558-79-4 8.5.3 Acute dermal toxicity Birch M.D. 1973 acute skin absorption minimal lethal Rabbits BK15 Younger Lab Y-73-85 disodium phosphate 3 7558-79-4 8.1 Skin irritation Birch M.D. 1973 In vivo skin irritation - rabbits Rabbits BK15 Younger Lab Y-73-85 disodium phosphate 3 7558-79-4 8.2 Eye Irritation Birch M.D. 1973 Eye irritation rabbits Rabbits BK15 Younger Lab Y-73-85 8.1 Skin irritation Bullock CH and In vivo skin irritation - rabbits rabbit T-1861 3 7558-79-4 1972 PS-2860 Stauffer Western RC disodium phosphate Kamienski FX Disodium hydrogenorthophosphate 3 7558-79-4 7.7 Water solubility O'Connor B 2009 A6 Water Solubility N/A IP Consortium Harlan 2920/0004 Disodium hydrogenorthophosphate 3 7558-79-4 7.2 Melting/freezing point O'Connor B 2009 Melting point N/A IP Consortium Harlan 2920/0004 Disodium hydrogenorthophosphate 3 7558-79-4 8.5.1 Acute oral toxicity Bradshaw J 2009 OECD 420 - Acute oral toxicity Rat IP Consortium Harlan 2920/0005 8.1 Skin irritation Younger F.M. In vivo skin irritation - rabbits Rabbits Y-62-69 part II 4 7601-54-9 1962 BK11 Younger Lab trisodium phosphate 4 7601-54-9 8.2 Eye Irritation Younger F.M. 1962 Eye irritation rabbits Rabbits BK11 Younger Lab Y-62-69 part II trisodium phosphate 4 7601-54-9 8.5.1 Acute oral toxicity Birch M.D. 1973 single oral dose Rats BK12 Younger Lab Y-73-119 trisodium phosphate 4 7601-54-9 8.5.3 Acute dermal toxicity Birch M.D. 1973 acute skin absorption minimal lethal Rabbits BK12 Younger Lab Y-73-119 trisodium phosphate 4 7601-54-9 8.1 Skin irritation Birch M.D. 1973 In vivo skin irritation - rabbits Rabbits BK12 Younger Lab Y-73-119 8.2 Eye Irritation Birch M.D. Eye irritation rabbits Rabbits Y-73-119 4 7601-54-9 1973 BK12 Younger Lab trisodium phosphate trisodium phosphate 4 7601-54-9 8.5.1 Acute oral toxicity Birch M.D. 1977 single oral dose Rats BK13 Younger Lab Y-77-27 trisodium phosphate 4 7601-54-9 8.5.3 Acute dermal toxicity Birch M.D. 1977 acute skin absorption minimal lethal Rabbits BK13 Younger Lab Y-77-27 trisodium phosphate 4 7601-54-9 8.1 Skin irritation Birch M.D. 1977 In vivo skin irritation - rabbits Rabbits BK13 Younger Lab Y-77-27 8.2 Eye Irritation Birch M.D. Eye irritation rabbits Rabbits Y-77-27 4 7601-54-9 1977 BK13 Younger Lab trisodium phosphate trisodium phosphate (dodecahydrate) 4 7601-54-9 8.5.1 Acute oral toxicity Pontrepka RF 1981 trisodium phosphate, crystalline. rat PS-2814 Stauffer Western RC T-10656 trisodium phosphate (dodecahydrate) 4 7601-54-9 8.5.3 Acute dermal toxicity Pontrepka RF 1981 trisodium phosphate, crystalline. rat PS-2814 Stauffer Western RC T-10656 trisodium phosphate (dodecahydrate) 4 7601-54-9 8.1 Skin irritation Pontrepka RF 1981 in vivo skin irritation - rat rat PS-2814 Stauffer Western RC T-10656 trisodium phosphate (dodecahydrate) 4 7601-54-9 8.2 Eye Irritation Pontrepka RF 1981 trisodium phosphate, crystalline. rabbit PS-2814 Stauffer Western RC T-10656 trisodium phosphate (dodecahydrate) 4 7601-54-9 9.1.3 Short-term toxicity testing on fish Potrepka RF 1981 None fish: Bluegill and PS-2814 Stauffer Western RC T-10656 trisodium phosphate - dodecahydrate 4 7601-54-9 8.1 Skin irritation Henderson L and 1974 In vivo skin irritation - rabbits rabbit PS-2882 Stauffer Western RC T-4894 8.1 Skin irritation Henderson L and In vivo skin irritation - rabbits rabbit T-4896 4 7601-54-9 1974 PS-2884 Stauffer Western RC trisodium phosphate Joiner RL Hazleton Laboratories. trisodium phosphate (dodecahydrate) 4 7601-54-9 8.1 Skin irritation Glaza SM 1992 Primary dermal irritation study of rabbit PS-3258 HWI 20200523 SponsorHazleton Rhone-Poulenc Laboratories. trisodium phosphate (dodecahydrate) 4 7601-54-9 8.1 Skin irritation Glaza SM 1992 Primary dermal irritation study of rabbit PS-3259 HWI 20200525 SponsorHazleton Rhone-Poulenc Laboratories. trisodium phosphate (dodecahydrate) 4 7601-54-9 8.2 Eye Irritation Glaza SM 1992 Primary eye irritation study of rabbit PS-3260 HWI 20200524 SponsorHazelton Rhone-Poulenc (for Rhone- trisodium phosphate (doedecahydrate) 4 7601-54-9 8.2 Eye Irritation Glaza SM 1992 Primary eye irritation study of rabbit PS-3261 HWI 20200526 Poulenc Inc) Trisodium orthophosphate 4 7601-54-9 7.7 Water solubility O'Connor B 2009 A6 Water Solubility N/A IP Consortium Harlan 2920/0006

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 13/01/2016 4 Sour

Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year 7.2 Melting/freezing point O'Connor B A6 Melting/Freezing Temperature N/A 2920/0006 4 7601-54-9 2009 IP Consortium Harlan Trisodium orthophosphate Trisodium orthophosphate 4 7601-54-9 8.5.1 Acute oral toxicity Bradshaw J 2009 OECD 420 - Acute oral toxicity Rat IP Consortium Harlan 2920/0007 Korean Ministry of trisodium orthophosphate 4 7601-54-9 8.4.1 In vitro gene mutation study in bacteria Unknown 2007 In vitro genen mutation in bacteria unknown unknown [unknown] Environment Sodium Acid Pyrophosphate 5 7758-16-9 8.5.2 Acute inhalation toxicity Signorin J. 1993 Acute inhalation toxicity rats Rats F34 FMC I 93-1755 8.4.1 In vitro gene mutation study in bacteria Newell G.W, Jorgenson Host-mediated assay mouse SR85X062 5 7758-16-9 1974 BK5 SRI sodium Acid Pyrophosphate T.A. Simon V.F. sodium Acid Pyrophosphate 5 7758-16-9 8.4.1 In vitro gene mutation study in bacteria Newell G.W, Jorgenson 1974 in vitro microbial assay bacteria BK5 SRI SR85X062 sodium Acid Pyrophosphate 5 7758-16-9 8.4.1 In vitro gene mutation study in bacteria Newell G.W, Jorgenson 1974 dominant lethal test Rats BK5 SRI SR85X062 sodium Acid Pyrophosphate 5 7758-16-9 8.4.1 In vitro gene mutation study in bacteria Newell G.W, Jorgenson 1974 mouse translocation test mouse BK5 SRI SR85X062 sodium acid Pyrophosphate 5 7758-16-9 8.5.1 Acute oral toxicity Newell G.W, Jorgenson 1974 Mutagenicity evaluation - precurser Rat, Mouse BK5 SRI SR85X062 sodium Acid Pyrophosphate 5 7758-16-9 8.5.1 Acute oral toxicity Birch M.D. 1973 single oral dose Rats BK6 Younger Lab Y-73-79 sodium Acid Pyrophosphate 5 7758-16-9 8.5.3 Acute dermal toxicity Birch M.D. 1973 acute skin absorption minimal lethal Rabbits BK6 Younger Lab Y-73-79 8.1 Skin irritation Birch M.D. In vivo skin irritation - rabbits Rabbits Y-73-79 5 7758-16-9 1973 BK6 Younger Lab sodium Acid Pyrophosphate sodium Acid Pyrophosphate 5 7758-16-9 8.2 Eye Irritation Birch M.D. 1973 Eye irritation rabbits Rabbits BK6 Younger Lab Y-73-79 Sodium pyrophosphate 5 7758-46-9 9.2.2.1 Hydrolysis as a function of pH Gaillot J.C. 1985 etude des especes phosphatees en water R3 0 448-6402 sodium Acid Pyrophosphate 5 7758-16-9 8.5.1 Acute oral toxicity Bullock CH and 1972 Toxicology lab report rat PS-2865 Stauffer Western RC T-4054 7.7 Water solubility Butler RE A6 Water Solubility N/A 2920/0039 5 7758-16-9 2009 IP Consortium Harlan Disodium dihydrogen pyrophosphate Disodium dihydrogen pyrophosphate 5 7758-16-9 7.2 Melting/freezing point Butler RE 2009 A6 Melting/Freezing Temperature N/A IP Consortium Harlan 2920/0039 Disodium dihydrogen pyrophosphate 5 7758-16-9 8.3 Skin sensitisation Bradshaw J 2009 OECD 429 - LLNA Mouse IP Consortium Harlan 2920/0040 Disodium dihydrogen pyrophosphate 5 7758-16-9 8.2 Eye Irritation Warren N 2009 Reconstructed Human Corneal Model in vitro tissues IP Consortium Harlan 2920/0096 Disodium dihydrogen pyrophosphate 5 7758-16-9 8.2 Eye Irritation Bradshaw J 2010 OECD 405 - Acute eye irritation Rabbit IP Consortium Harlan 2920/0126 Disodium dihydrogen pyrophosphate 5 7758-16-9 7.4 Relative Density Woolley A 2010 OECD 109 - Relative density N/A IP Consortium Harlan 2920/0105 Disodium dihydrogen pyrophosphate 5 7758-16-9 8.5.3 Acute dermal toxicity Bradshaw J 2010 Acute dermal toxicity (OECD 402) rat IP Consortium Harlan 2920/0141 8.5.1 Acute oral toxicity ? Acute oral toxicity Mouse Internal ref: 36318 5 7758-16-9 2009 P&G ? Diphosphric acid, sodium Korean Ministry of disodium dihydrogen pyrophosphate 5 14691-80-6 8.5.3 Acute dermal toxicity Unknown 2002 Acute dermal toxicity (OECD 402) unknown unknown [unknown] KoreanEnvironment Ministry of disodium dihydrogen pyrophosphate 5 14691-80-6 8.4.1 In vitro gene mutation study in bacteria Unknown 2002 In vitro genen mutation in bacteria unknown unknown [unknown] KoreanEnvironment Ministry of disodium dihydrogen pyrophosphate 5 14691-80-6 8.4.2 In vitro cytogenicity study in mammalian cells Unknown 2002 In vitro chromosomal abberation unknown unknown [unknown] Environment 9.1.3 Short-term toxicity testing on fish Unknown Aquatic toxicity to fish (OECD ?) unknown Korean Ministry of [unknown] 5 14691-80-6 2002 unknown disodium dihydrogen pyrophosphate Environment Korean Ministry of disodium dihydrogen pyrophosphate 5 14691-80-6 9.1.1 Short term toxicity testing on invertebrates Unknown 2002 Aquatic toxicity to invertebrates unknown unknown [unknown] Environment disodium dihydrogenpyrophosphate (+ 4.2% TSPP) 5 7758-16-9 8.2 Eye Irritation Pooles A 2011 Blend A1 / pH 5.0: Rabbit enucleated n/a - ex vivo BKG Harlan 41005056 TSPP) 5 7758-16-9 8.2 Eye Irritation Pooles A 2011 Blend B1 / pH 5.5: Rabbit enucleated n/a - ex vivo BKG Harlan 41005059 8.2 Eye Irritation Freeman C preliminary eye irritation rabbit FMC Sodium acid I86-0924 5 7758-16-9 1987 FMC sodium acid pyrophosphate pyro…. Trisodium hydrogen diphosphate 6 14691-80-6 7.2 Melting/freezing point Butler RE 2009 A6 Melting/Freezing Temperature N/A IP Consortium Harlan 2920/0041 Trisodium hydrogen diphosphate 6 14691-80-6 7.7 Water solubility Butler RE 2009 A6 Water Solubility N/A IP Consortium Harlan 2920/0041 Trisodium hydrogen diphosphate 6 14691-80-6 8.1 Skin corrosion Warren N 2010 OECD 431 - In vitro skin corrosion in vitro tissues IP Consortium Harlan 2920/0150 8.5.1 Acute oral toxicity Bradshaw J OECD 420 - Acute oral toxicity Rat 41200852 6 14691-80-6 2012 IP Consortium Harlan trisodium hydrogen diphosphate trisodium hydrogen diphosphate 6 14691-80-6 8.1 Skin irritation Warren N 2012 OECD 439 - In vitro skin irritancy RHE tissues IP Consortium Harlan 41200853 trisodium hydrogen diphosphate 6 14691-80-6 8.2 Eye Irritation Warren N 2012 OECD 437 - BCOP Bovine eyes IP Consortium Harlan 41200854 trisodium hydrogen diphosphate 6 14691-80-6 8.2 Eye Irritation Bradshaw J 2012 OECD 405 - Acute eye irritation rabbit IP Consortium Harlan 41200855 7.4 Relative Density Woolley A OECD 109 - Relative density n/a 41202043 6 14691-80-6 2012 IP Consortium Harlan trisodium hydrogen diphosphate trisodium hydrogen diphosphate 6 8.1 Skin irritation Lowe C 2012 OECD 404 / OPPTS 870.2500 Rabbit Rotem35321PEI Product Safety Labs 35321 Tetra-sodium pyrophosphate 7 7722-88-5 8.1 Skin irritation Freeman C 1988 In vivo skin irritation - rabbits Rabbits F27 FMC I 88-1008 tetrasodium pyrophosphate 7 7722-88-5 8.1 Skin irritation Younger F.M. 1962 In vivo skin irritation - rabbits Rabbits BK19 Younger Lab Y-62-70 tetrasodium pyrophosphate 7 7722-88-5 8.2 Eye Irritation Younger F.M. 1962 Eye irritation rabbits Rabbits BK19 Younger Lab Y-62-70 tetrasodium pyrophosphate 7 7722-88-5 8.5.1 Acute oral toxicity Birch M.D. 1973 single oral dose Rats BK20 Younger Lab Y-73-80 tetrasodium pyrophosphate 7 7722-88-5 8.5.3 Acute dermal toxicity Birch M.D. 1973 acute skin absorption minimal lethal Rabbits BK20 Younger Lab Y-73-80

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 13/01/2016 5 Sour

Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year 8.1 Skin irritation Birch M.D. In vivo skin irritation - rabbits Rabbits Y-73-80 7 7722-88-5 1973 BK20 Younger Lab tetrasodium pyrophosphate 8.2 Eye Irritation Birch M.D. Eye irritation rabbits Rabbits Y-73-80 7 7722-88-5 1973 BK20 Younger Lab tetrasodium pyrophosphate 8.1 Skin irritation Bullock CH and In vivo skin irritation - rabbits rabbit T-4054 7 7722-88-5 1972 PS-2865 Stauffer Western RC tetrasodium pyrophosphate Kamienski FX. tetrasodium pyrophosphate 7 7722-88-5 8.5.1 Acute oral toxicity Bullock CH and 1972 Toxicology lab report rat PS-2865 Stauffer Western RC T-4054 tetrasodium pyrophosphate 7 7722-88-5 8.5.1 Acute oral toxicity Jones B 1979 Toxicology lab report rat PS-2941 Stauffer Western RC T-6816 tetrasodium pyrophosphate 7 7722-88-5 8.5.3 Acute dermal toxicity Jones B 1979 Toxicology lab report rabbit PS-2941 Stauffer Western RC T-6816 tetrasodium pyrophosphate 7 7722-88-5 8.1 Skin irritation Jones B 1979 In vivo skin irritation - rabbits rabbit PS-2941 Stauffer Western RC T-6816 tetrasodium pyrophosphate 7 7722-88-5 8.2 Eye Irritation Jones B 1979 Toxicology lab report - in vivo rabbit PS-2941 Stauffer Western RC T-6816 tetrasodium pyrophosphate 7 7722-88-5 7.7 Water solubility Walker J 2009 A6 Water Solubility N/A IP Consortium Harlan 2920/0045 tetrasodium pyrophosphate 7 7722-88-5 8.5.1 Acute oral toxicity Bradshaw J 2009 OECD 420 - Acute oral toxicity rat IP Consortium Harlan 2920/0046 tetrasodium pyrophosphate 7 7722-88-5 8.2 Eye Irritation Warren N 2010 OECD 437 - BCOP bovine eye IP Consortium Harlan 2920/0130 tetrasodium pyrophosphate 7 7722-88-5 7.4 Relative Density Woolley A 2010 OECD 109 - Relative density N/A IP Consortium Harlan 2920/0106 tetrasodium pyrophosphate 7 7722-88-5 8.2 Eye Irritation Bradshaw J 2010 OECD 405 - Acute eye irritation Rabbit IP Consortium Harlan 41003232 tetrasodium pyrophosphate 7 7722-88-5 8.5.1 Acute oral toxicity Villigran A 2010 Acute oral toxicity (up and down rat Eurofins Rotem Amfet Negev Ltd 30229 tetrasodium pyrophosphate (+9.1% STPP, 1.6% SAPP) 7 7722-88-5 8.2 Eye Irritation Pooles A 2011 Blend B3 / pH 9.7: Rabbit enucleated n/a - ex vivo BKG Harlan 41005061 tetrasodium pyrophosphate (+8.4% SAPP) 7 7722-88-5 8.2 Eye Irritation Pooles A 2011 Blend A2 / pH 9.0: Rabbit enucleated n/a - ex vivo BKG Harlan 41005057 tetrasodium pyrophosphate (+1.8% SAPP) 7 7722-88-5 8.2 Eye Irritation Pooles A 2011 Blendeye A3 / pH 9.7: Rabbit enucleated n/arabbit - ex eye vivo BKG Harlan 41005058 tetrasodium pyrophosphate (+9.1% STPP, 7.6% SAPP) 7 7722-88-5 8.2 Eye Irritation Pooles A 2011 Blend B2 / pH 9.0: Rabbit enucleated n/a - ex vivo BKG Harlan 41005060 8.2 Eye Irritation Pooles A Blend B3 / pH 9.7: Acute eye Rabbit 41100383 7 7722-88-5 2011 BKG Harlan tetrasodium pyrophosphate (+9.1% STPP, 1.6% SAPP) irritation in vivo 8.2 Eye Irritation Pooles A Blend A3 / pH 9.7: Acute eye Rabbit 41100382 7 7722-88-5 2011 IP Consortium Harlan tetrasodium pyrophosphate (+1.8% SAPP) irritation in vivo 8.5.1 Acute oral toxicity Younger F.M. single oral dose Rats Y-61-83 8 7785-84-4 1961 BK17 Younger Lab sodium trimetaphosphate sodium trimetaphosphate 8 7785-84-4 8.1 Skin irritation Younger F.M. 1961 In vivo skin irritation - rabbits Rabbits BK17 Younger Lab Y-61-83 sodium trimetaphosphate 8 7785-84-4 8.2 Eye Irritation Younger F.M. 1961 Eye irritation rabbits Rabbits BK17 Younger Lab Y-61-83 sodium trimetaphosphate 8 7785-84-4 8.6.1 Short-term repeated dose toxicity Hodge C.H. 1956 pilot toxicity test Rats H1 Uni Rochester 0 sodium trimetaphosphate 8 7785-84-4 8.6.1 Short-term repeated dose toxicity Hodge C.H. 1956 pilot toxicity test Dogs H1 Uni Rochester 0 8.6.3 Long term repeated dose toxicity study Hodge C.H. chronic oral toxicity studies in rats Rats 0 8 7785-84-4 1960 H4 Uni Rochester sodium trimetaphosphate 8.6.3 Long term repeated dose toxicity study Hodge C.H. chronic oral toxicity studies in rats Rats 0 8 7785-84-4 1960 H4 Uni Rochester sodium trimetaphosphate sodium trimetaphosphate 8 7785-84-4 8.7.3 Two generation reproductive toxicity study Hodge C.H. 1960 chronic oral toxicity studies in rats Rats H4 Uni Rochester 0 8.9.1 Carcinogenicity Hodge C.H. chronic oral toxicity studies in rats Rats 0 8 7785-84-4 1960 H4 Uni Rochester sodium trimetaphosphate sodium trimetaphosphate 8 7785-84-4 8.5.1 Acute oral toxicity Kamienski FX 1971 Toxicology lab report rat PS-2839 Stauffer Western RC T-1680 8.5.3 Acute dermal toxicity Kamienski FX Toxicology lab report rabbit T-1680 8 7785-84-4 1971 PS-2839 Stauffer Western RC sodium trimetaphosphate 8.1 Skin irritation Kamienski FX In vivo skin irritation - rabbits rabbit T-1680 8 7785-84-4 1971 PS-2839 Stauffer Western RC sodium trimetaphosphate 8.2 Eye Irritation Kamienski FX Toxicology lab report rabbit T-1680 8 7785-84-4 1971 PS-2839 Stauffer Western RC sodium trimetaphosphate 8.1 Skin irritation Bullock CH and In vivo skin irritation - rabbits rabbit T-1861 8 7785-84-4 1972 PS-2860 Stauffer Western RC sodium trimetaphosphate Kamienski FX 7.2 Melting/freezing point Butler RE A6 Melting/Freezing Temperature N/A 2920/0061 8 7785-84-4 2009 IP Consortium Harlan Trisodium trimetaphosphate Trisodium trimetaphosphate 8 7785-84-4 7.7 Water solubility Butler RE 2009 A6 Water Solubility N/A IP Consortium Harlan 2920/0061 9.2.2.1 Hydrolysis as a function of pH O'Connor B Hydrolysis as a function of pH N/A 2920/0061 8 7785-84-4 2009 IP Consortium Harlan Trisodium trimetaphosphate

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Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year 7.13 Oxidising properties O'Connor B Oxidising properties expert N/A 2920/0061 8 7785-84-4 2009 statement IP Consortium Harlan Trisodium trimetaphosphate Trisodium trimetaphosphate 8 7785-84-4 7.11 Explosive properties O'Connor B 2009 Explosivity expert statement N/A IP Consortium Harlan 2920/0061 8.5.1 Acute oral toxicity Bradshaw J OECD 420 - Acute oral toxicity Rat 2920/0076 8 7785-84-4 2009 IP Consortium Harlan Trisodium trimetaphosphate 8.3 Skin sensitisation Bradshaw J OECD 429 - LLNA Mouse 2920/0077 8 7785-84-4 2009 IP Consortium Harlan Trisodium trimetaphosphate 7.4 Relative Density Woolley A OECD 109 - Relative density N/A 2920/0109 8 7785-84-4 2010 IP Consortium Harlan Trisodium trimetaphosphate 9.1.1 Short term toxicity testing on invertebrates Weber B OECD 202 - Acute toxicity in daphnia daphnia C60787 - DSM 8 7785-84-4 2010 DSM Harlan Trisodium trimetaphosphate 9.1.2 Growth inhibition study in aquatic plants Weber B OECD 201 - Algal growth inhibition algae C60798 - DSM 8 7785-84-4 2010 DSM Harlan Trisodium trimetaphosphate 8.2 Eye Irritation Barnett D and Nixon G Rabbit eye irritation Rabbit 8 7785-84-4 1972 P&G IP8 P&G Glass H polyphosphate - IP8? 8.1 Skin irritation Frank R, Nixon G dermal irritation Rabbit 8452 8 7785-84-4 1972 P&G IP8 P&G Glass H polyphosphate - IP8? 8.5.1 Acute oral toxicity Whalen J and Klusman Acute oral toxicity Rat 8350 8 7785-84-4 1972 P&G IP8 P&G Glass H polyphosphate - IP8? W 8.6.1 Short-term repeated dose toxicity Johnson GR Substance oral toxicity Rat 11420 8 7785-84-4 1973 P&G IP8 P&G trimetaphosphate - IP8? 9.1.3 Short-term toxicity testing on fish Goodband T OECD 203 (semi-static) fish: rainbow 41200856 8 7785-84-4 2012 IP Consortium Harlan Trisodium trimetaphosphate trout 9.1.4 Activated sludge respiration inhibition Clarke N OECD 209 - ASRI Algae 41200858 8 7785-84-4 2012 IP Consortium Harlan Trisodium trimetaphosphate testing 8.5.2 Acute inhalation toxicity Griffiths D OECD 436 - Acute inhalation Rat 41200859 8 7785-84-4 2012 IP Consortium Harlan Trisodium trimetaphosphate 7.4 Relative Density [not provided by Relative density n/a BK1511A_ 8 7758-84-4 2012 BKG BKG Trisodium trimetaphosphate sponsor] 8.5.1 Acute oral toxicity Bullock CH and Toxicology lab report rat T-4054 9 68915-31-1 1972 PS-2865 Stauffer Western RC sodium hexametaphosphate Kamienski FX. 9.1.1 Short term toxicity testing on invertebrates Yurk J.J. Acute toxicity Daphnia Daphnia I 92-1271 10 10124-56-8 1993 F12 ESE Gainsville Sodium hexametaphosphate 8.2 Eye Irritation Freeman C Eye irritation rabbits Rabbits I 86-915 10 10124-56-8 1986 F16 FMC Sodium hexametaphosphate 8.1 Skin irritation Freeman C In vivo skin irritation - rabbits Rabbits I 90-1136 10 10124-56-8 1990 F31 FMC Sodium hexametaphosphate 8.5.2 Acute inhalation toxicity Signorin J. Acute inhalation toxicity rats Rats I 93-1756 10 10124-56-8 1993 F35 FMC Sodium hexametaphosphate 8.6.1 Short-term repeated dose toxicity Hodge C.H. pilot toxicity test Rats 0 10 10124-56-8 1956 H1 Uni Rochester sodium metaphosphate 8.6.1 Short-term repeated dose toxicity Hodge C.H. pilot toxicity test Dogs 0 10 10124-56-8 1956 H1 Uni Rochester sodium metaphosphate 8.6.3 Long term repeated dose toxicity study Hodge C.H. chronic oral toxicity studies in rats Rats 0 10 10124-56-8 1960 H3 Uni Rochester sodium hexametaphosphate 8.5.1 Acute oral toxicity Hodge C.H. Acute oral toxicity Rats 0 10 10124-56-8 1960 H3 Uni Rochester sodium hexametaphosphate 8.7.3 Two generation reproductive toxicity study Hodge C.H. chronic oral toxicity studies in rats Rats 0 10 10124-56-8 1960 H3 Uni Rochester sodium hexametaphosphate 8.9.1 Carcinogenicity Hodge C.H. chronic oral toxicity studies in rats Rats 0 10 10124-56-8 1960 H3 Uni Rochester sodium hexametaphosphate 8.1 Skin irritation Bullock CH and In vivo skin irritation - rabbits rabbit T-1861 10 68915-31-1 1972 PS-2860 Stauffer Western RC sodium hexametaphosphate Kamienski FX

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Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year 7.7 Water solubility Butler RE A6 Water Solubility N/A 2920/0062 10 10124-56-8 2009 IP Consortium Harlan Sodium metaphosphate 7.2 Melting/freezing point Butler RE A6 Melting/Freezing Temperature N/A 2920/0062 10 10124-56-8 2009 IP Consortium Harlan Sodium metaphosphate 7.7 Water solubility Butler RE A6 Water Solubility N/A 2920/0062 10 10124-56-8 2009 IP Consortium Harlan Sodium metaphosphate 9.2.2.1 Hydrolysis as a function of pH Butler RE Hydrolysis as a function of pH N/A 2920/0062 10 10124-56-8 2009 IP Consortium Harlan Sodium metaphosphate Sodium metaphosphate 10 10124-56-8 7.13 Oxidising properties O'Connor B 2009 Oxidising properties expert N/A IP Consortium Harlan 2920/0062 Sodium metaphosphate 10 10124-56-8 7.11 Explosive properties O'Connor B 2009 Explosivity expert statement N/A IP Consortium Harlan 2920/0062 Sodium metaphosphate 10 10124-56-8 8.3 Skin sensitisation Bradshaw J 2009 OECD 429 - LLNA Mouse IP Consortium Harlan 2920/0063 Sodium metaphosphate 10 10124-56-8 8.5.1 Acute oral toxicity Bradshaw J 2009 OECD 420 - Acute oral toxicity Rat IP Consortium Harlan 2920/0097 Sodium metaphosphate 10 10124-56-8 7.4 Relative Density Woolley A 2010 OECD 109 - Relative density N/A IP Consortium Harlan 2920/0110 Sodium metaphosphate 10 10124-56-8 9.1.3 Short-term toxicity testing on fish Priestly S 2010 OECD 203 (semi-static) fish: rainbow IP Consortium Harlan 2920/0112 Sodium metaphosphate 10 10124-56-8 9.1.2 Growth inhibition study in aquatic plants Vryenhoef H 2010 OECD 201 - Algal growth inhibition algae IP Consortium Harlan 2920/0113 Sodium metaphosphate 10 10124-56-8 9.1.4 Activated sludge respiration inhibition Clarke N 2010 OECD 209 - ASRI soil IP Consortium Harlan 2920/0114 sodium metaphosphate insoluble HO3PNa 11 10361-03-2 9.1.1 Short term toxicity testing on invertebrates Dr. H. Lebertz 1999 Acute toxicity Daphnia Daphnia B12 Fresenius 98TE181175 insoluble sodium metaphosphate 11 10361-03-2 8.5.1 Acute oral toxicity Birch M.D. 1973 single oral dose Rats BK18 Younger Lab Y-73-76 8.5.3 Acute dermal toxicity Birch M.D. acute skin absorption minimal lethal Rabbits Y-73-76 11 10361-03-2 1973 BK18 Younger Lab insoluble sodium metaphosphate dose insoluble sodium metaphosphate 11 10361-03-2 8.1 Skin irritation Birch M.D. 1973 In vivo skin irritation - rabbits Rabbits BK18 Younger Lab Y-73-76 insoluble sodium metaphosphate 11 10361-03-2 8.2 Eye Irritation Birch M.D. 1973 Eye irritation rabbits Rabbits BK18 Younger Lab Y-73-76 insoluble sodium metaphosphate 11 10361-03-2 8.1 Skin irritation Bullock CH and 1972 In vivo skin irritation - rabbits rabbit PS-2860 Stauffer Western RC T-1861 Mono- phosphate 12 7778-77-0 8.1 Skin irritation Freeman C 1990 In vivo skin irritation - rabbits Rabbits F17 FMC I 90-1131 Mono- 12 7778-77-0 8.2 Eye Irritation Freeman C 1986 Eye irritation rabbits Rabbits F18 FMC I 86-0927 12 7778-77-0 8.5.1 Acute oral toxicity Birch M.D. 1973 single oral dose Rats BK21 Younger Lab Y-73-117 monopotassium phosphate 12 7778-77-0 8.5.3 Acute dermal toxicity Birch M.D. 1973 acute skin absorption minimal lethal Rabbits BK21 Younger Lab Y-73-117 monopotassium phosphate 12 7778-77-0 8.1 Skin irritation Birch M.D. 1973 In vivo skin irritation - rabbits Rabbits BK21 Younger Lab Y-73-117 8.2 Eye Irritation Birch M.D. Eye irritation rabbits Rabbits Y-73-117 12 7778-77-0 1973 BK21 Younger Lab monopotassium phosphate 8.1 Skin irritation Bullock CH and In vivo skin irritation - rabbits rabbit T-4054 Kamienski FX. 12 7778-77-0 1972 PS-2865 Stauffer Western RC monopotassium phosphate 8.5.1 Acute oral toxicity Kamienski FX Toxicology lab report rat T-1680 12 7778-77-0 1971 PS-2839 Stauffer Western RC monopotassium phosphate 8.5.3 Acute dermal toxicity Kamienski FX Toxicology lab report rabbit T-1680 12 7778-77-0 1971 PS-2839 Stauffer Western RC monopotassium phosphate 8.1 Skin irritation Kamienski FX In vivo skin irritation - rabbits rabbit T-1680 12 7778-77-0 1971 PS-2839 Stauffer Western RC monopotassium phosphate 8.2 Eye Irritation Kamienski FX Toxicology lab report rabbit T-1680 12 7778-77-0 1971 PS-2839 Stauffer Western RC monopotassium phosphate 7.3 Boiling point Walker J Boiling point N/A 2920/0008 12 7778-77-0 2009 IP Consortium Harlan monopotassium phosphate 7.5 Vapour pressure Walker J Vapour pressure N/A 2920/0008 12 7778-77-0 2009 IP Consortium Harlan monopotassium phosphate

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Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year 7.7 Water solubility Walker J A6 Water Solubility N/A 2920/0008 12 7778-77-0 2009 IP Consortium Harlan monopotassium phosphate 7.4 Relative Density Woolley A OECD 109 - Relative density N/A 2920/0099 12 7778-77-0 2010 IP Consortium Harlan monopotassium phosphate 8.1 Skin irritation Freeman C In vivo skin irritation - rabbits Rabbits I 87-0952 13 7758-11-4 1987 F13 FMC 8.5.3 Acute dermal toxicity Freeman C Skin irritation and toxicity rabbits Rabbits I 87-0952 13 7758-11-4 1987 F13 FMC Dipotassium phosphate 8.2 Eye Irritation Freeman C Eye irritation rabbits Rabbits I 86-0929 13 7758-11-4 1987 F20 FMC Dipotassium phosphate 8.5.1 Acute oral toxicity Freeman C Preliminary oral toxicity - Rats Rats I 87-0951 13 7758-11-4 1987 F23 FMC Di-potassium phosphate 8.1 Skin irritation Freeman C In vivo skin irritation - rabbits Rabbits I 87-0952 13 7758-11-4 1987 F24 FMC Di-potassium phosphate 8.5.3 Acute dermal toxicity Freeman C Skin irritation and toxicity rabbits Rabbits I 87-0952 13 7758-11-4 1987 F24 FMC Di-potassium phosphate 8.2 Eye Irritation Blaszcak D.L. Eye irritation rabbits Rabbits BD-86-191 13 7758-11-4 1986 BK22 Bio dynamics dipotassium phosphate 8.5.1 Acute oral toxicity Blaszcak D.L. Acute oral toxicity Rat BD-86-191 13 7758-11-4 1986 BK22 Bio dynamics dipotassium phosphate 8.5.3 Acute dermal toxicity Blaszcak D.L. Acute dermal toxicity Rabbit BD-86-191 13 7758-11-4 1986 BK22 Bio dynamics dipotassium phosphate 8.5.1 Acute oral toxicity Bullock CH and Toxicology lab report rat T-4054 13 7785-11-4 1972 PS-2865 Stauffer Western RC dipotassium phosphate Kamienski FX. 8.5.1 Acute oral toxicity Terrel Y and Parke G Acute oral toxicity in rats. rat M41-75 13 7758--11-4 1975 PS-3736 Cannon (for Mobil) dipotassium phosphate Compound: TDR-41-75 8.5.1 Acute oral toxicity Terrel Y and Parke G Acute oral toxicity in rats. rat M42-75 13 7758--11-4 1975 PS-3737 Cannon (for Mobil) dipotassium phosphate Compound: MCTR-4-75 8.5.3 Acute dermal toxicity Imlay P and Parke G Report on the acute dermal toxicity rabbit M2562-77 13 7758--11-4 1977 PS-3738 Cannon (for Mobil) dipotassium phosphate of rabbits 8.4.1 In vitro gene mutation study in bacteria Jagannath DR Mutagenicity evaluation of MCTR- Salmonella, Litton Bionetics Inc (for M2561-77 / LBI No. 20838 13 7758--11-4 1977 PS-3739 dipotassium phosphate 256 S.cerevisiae Mobil) 8.1 Skin irritation Bullock CH and In vivo skin irritation - rabbits rabbit T-1861 13 7758--11-4 1972 PS-2860 Stauffer Western RC dipotassium phosphate Kamienski FX 8.2 Eye Irritation Terrel Y and Parke G The effects of MCTR-4-75 on the eye rabbit M43-75 13 7758-11-4 1975 11_AW Cannon (for Mobil) dipotassium phosphate mucosa of New Zealand albino 8.1 Skin irritation Becker J and Parke G A primary dermal irritation study of rabbit M44-75 13 7758-11-4 1975 12_AW Cannon (for Mobil) dipotassium phosphate MCTR-4-75 on abraded and 8.4.1 In vitro gene mutation study in bacteria Jagannath DR Mutagenicity evaluation of MCTR- Salmonella M2561-77 / LBI: 20838 Litton Bionetics (for 13 7758-11-4 1977 256 typhimurium 25_AW Mobil) dipotassium phosphate 8.6.1 Short-term repeated dose toxicity and 8.7.1 Shim YH OECD 422: 28-day repeated dose and Rat R05078 13 7758-11-4 Screening for reproductive/developmental toxicity 2005 reprotoxicity study NIER - Korea Biotoxtech Co., Ltd. dipotassium phosphate study 7.2 Melting/freezing point Walker J A6 Melting/Freezing Temperature N/A 2920/0009 13 7758-11-4 2009 IP Consortium Harlan dipotassium phosphate 7.7 Water solubility Walker J A6 Water Solubility N/A 2920/0009 13 7758-11-4 2009 IP Consortium Harlan dipotassium phosphate

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Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year dipotassium phosphate 13 7758-11-4 7.4 Relative Density Walker J 2010 OECD 109 - Relative density N/A IP Consortium Harlan 2920/0100 dipotassium phosphate 13 7758-11-4 9.1.4 Activated sludge respiration inhibition Clarke N 2010 OECD 209 - ASRI soil IP Consortium Harlan 2920/0121 dipotassium phosphate 13 7758-11-4 8.5.1 Acute oral toxicity Bradshaw J 2010 OECD 420 - Acute oral toxicity rat IP Consortium Harlan 2920/0140 Tri-potassium phosphate 14 7778-53-2 8.1 Skin irritation Freeman C 1987 In vivo skin irritation - rabbits Rabbits F14 FMC I 87-0954 Tri-potassium phosphate 14 7778-53-2 8.5.3 Acute dermal toxicity Freeman C 1987 Skin irritation and toxicity rabbits Rabbits F14 FMC I 87-0954 Tripotassium phosphate 14 7778-53-2 8.5.1 Acute oral toxicity Birch M.D. 1976 single oral dose Rats BK23 Younger Lab Y-76-343 Tripotassium phosphate 14 7778-53-2 8.5.3 Acute dermal toxicity Birch M.D. 1976 acute skin absorption minimal lethal Rabbits BK23 Younger Lab Y-76-343 Tripotassium phosphate 14 7778-53-2 8.1 Skin irritation Birch M.D. 1976 In vivo skin irritation - rabbits Rabbits BK23 Younger Lab Y-76-343 Tripotassium phosphate 14 7778-53-2 8.2 Eye Irritation Birch M.D. 1976 Eye irritation rabbits Rabbits BK23 Younger Lab Y-76-343 Tripotassium phosphate 14 7778-53-2 8.5.1 Acute oral toxicity Terrell Y and Parke G 1975 Acute oral toxicity in rats. rat PS-3709 Cannon (for Mobil) M0071-75 /M71-75 Tripotassium phosphate 14 7778-53-2 8.5.1 Acute oral toxicity Terrell Y and Parke G 1975 Acute oral toxicity in rats. rat PS-3710 Cannon (for Mobil) M0072-75 / M72-75 Litton Bionetics (for Tripotassium phosphate (liquid) 14 7778-53-2 8.4.1 In vitro gene mutation study in bacteria Jagannath DR 1977 Mutagenicity evaluation of MCTR- Salmonella, S. PS-3711 LBI project no: 20838 Mobil) Tripotassium phosphate (liquid) 14 7778-53-2 8.5.3 Acute dermal toxicity Imlay P and Parke G 1977 Report on the acute dermal toxicity rabbit PS-3735 Cannon (for Mobil) M2582-77 tripotassium phosphate 14 7778-53-2 8.5.1 Acute oral toxicity Kamienski FX 1971 Toxicology lab report rat PS-2839 Stauffer Western RC T-1680 tripotassium phosphate 14 7778-53-2 8.5.3 Acute dermal toxicity Kamienski FX 1971 Toxicology lab report rabbit PS-2839 Stauffer Western RC T-1680 tripotassium phosphate 14 7778-53-2 8.1 Skin irritation Kamienski FX 1971 In vivo skin irritation - rabbits rabbit PS-2839 Stauffer Western RC T-1680 8.2 Eye Irritation Kamienski FX Toxicology lab report rabbit T-1680 14 7778-53-2 1971 PS-2839 Stauffer Western RC tripotassium phosphate 8.2 Eye Irritation Parke G The effects of MCTR-7-75 on the eye rabbit M73-75 14 7778-53-2 1975 4_AW Cannon (for Mobil) tripotassium phosphate mucosa of New Zealand albino Tripotassium phosphate 14 7778-53-2 8.5.1 Acute oral toxicity Terrell Y and Parke G 1975 Acute oral toxicity in rats. rat 19_AW Cannon (for Mobil) M0071-75 /M71-75 tripotassium phosphate 14 7778-53-2 8.1 Skin irritation Becker J and Parke G 1975 A primary dermal irritation study of rabbit 22_AW Cannon (for Mobil) M74-75 Litton Bionetics Inc (for tripotassium phosphate 14 7778-53-2 8.4.1 In vitro gene mutation study in bacteria Jagannath DR 1977 Mutagenicity evaluation of MCTR- Salmonella, 27_AW M2581-77 / LBI No.20838 Mobil) tripotassium orthophosphate 14 7778-53-2 7.7 Water solubility Walker J 2009 A6 Water Solubility N/A IP Consortium Harlan 2920/0010 Korean Ministry of tripotassium orthophosphate 14 7778-53-2 8.4.3 In vitro gene mutation study in mammalian Unknown 2007 in vitro mammalian mouse unknown unknown [unknown] KoreanEnvironment Ministry of tripotassium orthophosphate 14 7778-53-2 9.1.3 Short-term toxicity testing on fish Unknown 2007 Aquatic toxicity to fish (OECD ?) unknown unknown [unknown] KoreanEnvironment Ministry of tripotassium orthophosphate 14 7778-53-2 9.1.1 Short term toxicity testing on invertebrates Unknown 2007 Aquatic toxicity to invertebrates unknown unknown [unknown] Environment tripotassium phosphate (50% aqueous solution) 14 7778-53-2 8.1 Skin irritation Frank R and Nixon G 1976 skin irritation in vivo Rabbit P&G IP14 P&G 14287 tripotassium orthophosphate 14 7778-53-2 8.1 Skin irritation Warren N 2012 OECD 439 - In vitro skin irritancy RHE tissues IP Consortium Harlan 41200860 Tetrapotassium pyrophosphate 15 7320-34-5 9.1.1 Short term toxicity testing on invertebrates Vaishnav D.D., Yurk 1991 Acute toxicity Daphnia Daphnia F11 ESE Gainsville I 89-1092 Tetrapotassium pyrophosphate 15 7320-34-5 8.2 Eye Irritation Freeman C 1987 Eye irritation rabbits Rabbits F21 FMC I 86-0930 8.1 Skin irritation Freeman C In vivo skin irritation - rabbits Rabbits I 88-1006 15 7320-34-5 1988 F25 FMC Tetra-potassium pyrophosphate Tetra-potassium pyrophosphate 15 7320-34-5 8.5.3 Acute dermal toxicity Freeman C 1988 Skin toxicity rabbits Rabbits F26 FMC I 88-1007 Tetrapotassium pyrophosphate 15 7320-34-5 8.5.2 Acute inhalation toxicity Signorin J. 1993 Acute inhalation toxicity rats Rats F36 FMC I 93-1757 tetrapotassium phosphate 15 7320-34-5 8.5.1 Acute oral toxicity Birch M.D. 1973 single oral dose Rats BK24 Younger Lab Y-73-114 tetrapotassium phosphate 15 7320-34-5 8.5.3 Acute dermal toxicity Birch M.D. 1973 acute skin absorption minimal lethal Rabbits BK24 Younger Lab Y-73-114 tetrapotassium phosphate 15 7320-34-5 8.1 Skin irritation Birch M.D. 1973 In vivo skin irritation - rabbits Rabbits BK24 Younger Lab Y-73-114 tetrapotassium phosphate 15 7320-34-5 8.2 Eye Irritation Birch M.D. 1973 Eye irritation rabbits Rabbits BK24 Younger Lab Y-73-114 tetra-potassium pyrophosphate 15 7320-34-5 8.5.1 Acute oral toxicity Younger F.M. 1961 single oral dose Rats BK25 Younger Lab Y-61-24 tetra-potassium pyrophosphate 15 7320-34-5 8.1 Skin irritation Younger F.M. 1961 In vivo skin irritation - rabbits Rabbits BK25 Younger Lab Y-61-24 tetra-potassium pyrophosphate 15 7320-34-5 8.2 Eye Irritation Younger F.M. 1961 Eye irritation rabbits Rabbits BK25 Younger Lab Y-61-24 Tetrapotassium pyrophosphate 15 7320-34-5 8.1 Skin irritation Bullock CH and 1972 In vivo skin irritation - rabbits rabbit PS-2865 Stauffer Western RC T-4054 tetrapotassium pyrophosphate (liquid) 15 7320-34-5 8.5.3 Acute dermal toxicity Imlay P and Parke G 1977 Report on the acute dermal toxicity rabbit PS-3712 Cannon (for Mobil) M2571-77 tetrapotassium pyrophosphate 15 7320-34-5 8.5.1 Acute oral toxicity Terrel Y and Parke G 1975 Acute oral toxicity in rats. rat PS-3732 Cannon (for Mobil) M62-75 8.5.1 Acute oral toxicity Terrel Y and Parke G Acute oral toxicity in rats. rat M61-75 15 7320-34-5 1975 PS-3733 Cannon (for Mobil) tetrapotassium pyrophosphate Compound: MCTR-6-75 8.4.1 In vitro gene mutation study in bacteria Brusick DJ Mutagenicity evaluation of MCTR- Salmonella, Litton Bionetics Inc (for M2581-77 / LBI No.20838 15 7320-34-5 1977 PS-3734 tetrapotassium pyrophosphate (liquid) 257 S.cerevisiae Mobil) 8.5.1 Acute oral toxicity Kamienski FX Toxicology lab report rat T-1680 15 7320-34-5 1971 PS-2839 Stauffer Western RC tetrapotassium pyrophosphate 8.5.3 Acute dermal toxicity Kamienski FX Toxicology lab report rabbit T-1680 15 7320-34-5 1971 PS-2839 Stauffer Western RC tetrapotassium pyrophosphate

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 13/01/2016 10 Sour

Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year 8.1 Skin irritation Kamienski FX In vivo skin irritation - rabbits rabbit T-1680 15 7320-34-5 1971 PS-2839 Stauffer Western RC tetrapotassium pyrophosphate 8.2 Eye Irritation Kamienski FX Toxicology lab report rabbit T-1680 15 7320-34-5 1971 PS-2839 Stauffer Western RC tetrapotassium pyrophosphate 8.2 Eye Irritation Parke G The effects of MCTR-6-75 on the eye rabbit M63-75 15 7320-34-5 1975 17_AW Cannon (for Mobil) tetrapotassium pyrophosphate mucosa of New Zealand albino 8.1 Skin irritation Becker J and Parke G A primary dermal irritation study of rabbit M64-75 15 7320-34-5 1975 CL_M44-75 Cannon (for Mobil) tetrapotassium pyrophosphate MCTR-6-75 on abraded and 7.7 Water solubility Walker J A6 Water Solubility N/A 2920/0047 15 7320-34-5 2009 IP Consortium Harlan tetrapotassium pyrophosphate 9.2.2.1 Hydrolysis as a function of pH O'Connor B Hydrolysis as a function of pH N/A 2920/0047 15 7320-34-5 2009 IP Consortium Harlan tetrapotassium pyrophosphate 7.4 Relative Density Woolley A OECD 109 - Relative density N/A 2920/0107 15 7320-34-5 2010 IP Consortium Harlan tetrapotassium pyrophosphate 8.2 Eye Irritation Freeman C Eye irritation rabbits Rabbits I 86-0928 16 13845-36-8 1987 F19 FMC Potassium tri-polyphosphate 8.1 Skin irritation Freeman C In vivo skin irritation - rabbits Rabbits I 90-1133 16 13845-36-8 1990 F30 FMC Potassium tri-polyphosphate 8.1 Skin irritation Bullock CH and In vivo skin irritation - rabbits rabbit T-4054 Kamienski FX. 16 13845-36-8 1972 PS-2865 Stauffer Western RC Potassium tri-polyphosphate 8.5.1 Acute oral toxicity Kamienski FX Toxicology lab report rat T-1680 16 13845-36-8 1971 PS-2839 Stauffer Western RC potassium tripolyphosphate 8.5.3 Acute dermal toxicity Kamienski FX Toxicology lab report rabbit T-1680 16 13845-36-8 1971 PS-2839 Stauffer Western RC potassium tripolyphosphate 8.1 Skin irritation Kamienski FX In vivo skin irritation - rabbits rabbit T-1680 16 13845-36-8 1971 PS-2839 Stauffer Western RC potassium tripolyphosphate 8.2 Eye Irritation Kamienski FX Toxicology lab report rabbit T-1680 16 13845-36-8 1971 PS-2839 Stauffer Western RC potassium tripolyphosphate 7.7 Water solubility O'Connor B A6 Water Solubility N/A 2920/0053 16 13845-36-8 2009 IP Consortium Harlan Pentapotassium triphosphate 7.2 Melting/freezing point O'Connor B A6 Melting/Freezing Temperature N/A 2920/0092 16 13845-36-8 2009 IP Consortium Harlan Pentapotassium triphosphate 8.5.1 Acute oral toxicity Bradshaw J OECD 420 - Acute oral toxicity rat 2920/0054 16 13845-36-8 2009 IP Consortium Harlan Pentapotassium triphosphate 7.4 Relative Density Woolley A OECD 109 - Relative density N/A 2920/0108 16 13845-36-8 2010 IP Consortium Harlan Pentapotassium triphosphate 8.5.1 Acute oral toxicity Birch M.D. single oral dose Rats Y-73-81 18 7722-76-1 1973 BK10 Younger Lab monoammonium phosphate monoammonium phosphate 18 7722-76-1 8.5.3 Acute dermal toxicity Birch M.D. 1973 acute skin absorption minimal lethal Rabbits BK10 Younger Lab Y-73-81 monoammonium phosphate 18 7722-76-1 8.1 Skin irritation Birch M.D. 1973 In vivo skin irritation - rabbits Skin irritation - BK10 Younger Lab Y-73-81 monoammonium phosphate 18 7722-76-1 8.2 Eye Irritation Birch M.D. 1973 Eye irritation rabbits Rabbits BK10 Younger Lab Y-73-81 monoammonium phosphate 18 7722-76-1 8.1 Skin irritation Bullock CH and 1972 In vivo skin irritation - rabbits rabbit PS-2865 Stauffer Western RC T-4054 Product Safety monoammonium phosphate 18 7722-76-1 8.5.3 Acute dermal toxicity ? 2000 Acute dermal toxicity study in rats - ? TFI/EFMA 9738 Laboratories monoammonium phosphate 18 7722-76-1 9.1.3 Short-term toxicity testing on fish ? 2000 OECD 203 (static) fish: Rainbow TFI/EFMA ABC laboratories 46201

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 13/01/2016 11 Sour

Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year Product Safety monoammonium phosphate 18 7722-76-1 8.5.1 Acute oral toxicity ? 2000 Acute oral toxicity up and down ? TFI/EFMA 9737 FARM, BASF - need Laboratories monoammonium phosphate 18 7722-76-1 8.1 Skin irritation [unknown] In vivo skin irritation - rabbits rabbits [unknown] FARM,permissionfor BASF - needread monoammonium phosphate 18 7722-76-1 8.2 Eye Irritation [unknown] Eye irritation - BCOP bovine eyes [unknown] permissionfor read 8.4.3 In vitro gene mutation study in mammalian [unknown] In vitro mammalian cell gene mouse Co-owner; can be 18 7722-76-1 [unknown] monoammonium phosphate cells mutation test lymphoma used for all purposes. 8.1 Skin irritation Branch, D.K In vivo skin irritation - rabbits rabbits PHOS-CHEK-D-75 contains monoammonium phosphate to 18 7722-76-1 1981 Monsanto [unknown] an unknown concentration 8.5.1 Acute oral toxicity Branch D.K. Acute oral toxicity in the rat rat PHOS-CHEK-D-75 contains monoammonium phosphate to 18 7722-76-1 1981 FARM [unknown] an unknown concentration 8.5.1 Acute oral toxicity Branch D.K. Acute oral toxicity - rabbts rabbits 18 7722-76-1 1981 FARM [unknown] PHOS-CHEK-D-75 contains monoammonium phosphate to an unknown concentration 9.1.1 Short term toxicity testing on invertebrates Dr. H. Lebertz Acute toxicity Daphnia Daphnia 99TE029486 19 7783-28-0 1999 B20 Fresenius diammonium phosphate 8.5.1 Acute oral toxicity Younger F.M. single oral dose Rats Y-65-176 19 7783-28-0 1965 BK8 Younger Lab PhosCheck202 (diammonium phosphates mix) 8.5.3 Acute dermal toxicity Younger F.M. acute skin absorption minimal lethal Rabbits Y-65-176 19 7783-28-0 1965 BK8 Younger Lab PhosCheck202 (diammonium phosphates mix) dose 8.1 Skin irritation Younger F.M. In vivo skin irritation - rabbits Rabbits Y-65-176 19 7783-28-0 1965 BK8 Younger Lab PhosCheck202 (diammonium phosphates mix) PhosCheck202 (diammonium phosphates mix) 19 7783-28-0 8.2 Eye Irritation Younger F.M. 1965 Eye irritation rabbits Rabbits BK8 Younger Lab Y-65-176 diammonium phosphate 19 7783-28-0 8.5.1 Acute oral toxicity Birch M.D. 1973 single oral dose Rats BK9 Younger Lab Y-73-83 8.5.3 Acute dermal toxicity Birch M.D. acute skin absorption minimal lethal Rabbits Y-73-83 19 7783-28-0 1973 BK9 Younger Lab diammonium phosphate dose 8.1 Skin irritation Birch M.D. In vivo skin irritation - rabbits Rabbits Y-73-83 19 7783-28-0 1973 BK9 Younger Lab diammonium phosphate 8.2 Eye Irritation Birch M.D. Eye irritation rabbits Rabbits Y-73-83 19 7783-28-0 1973 BK9 Younger Lab diammonium phosphate 8.1 Skin irritation Bullock CH and In vivo skin irritation - rabbits rabbit T-4054 19 7783-28-0 Kamienski FX. 1972 PS-2865 Stauffer Western RC diammonium phosphate 8.5.1 Acute oral toxicity Bullock CH and Toxicology lab report rat T-4054 19 7783-28-0 1972 PS-2865 Stauffer Western RC diammonium phosphate Kamienski FX. 9.1.2 Growth inhibition study in aquatic plants ? Toxicity of diammonium phosphate Algae 46207 19 7783-28-0 2000 (DAP) to unicellular green alga, TFI/EFMA ABC laboratories diammonium phosphate Selenastrum capricornutum diammonium phosphate 19 7783-28-0 8.4.2 In vitro cytogenicity study in mammalian cells ? 2000 In vitro mammalian chromosome N/A TFI/EFMA BioReliance AA43RB.331.BTL 8.5.1 Acute oral toxicity ? Acute oral toxicity up and down rat 9733 procedure in rats 19 7783-28-0 2000 TFI/EFMA ABC laboratories diammonium phosphate 8.7.1 Screening for reproductive developmental ? 4-week general toxicity and ? 22948 19 7783-28-0 toxicity 2002 reproductive / development toxicity TFI/EFMA HLS diammonium phosphate screening test 8.4.1 In vitro gene mutation study in bacteria ? Bacterial reverse mutation assay ? A43RB.503.BTL 19 7783-28-0 2001 TFI/EFMA BioReliance diammonium phosphate 8.5.3 Acute dermal toxicity ? Acute dermal toxicity study in rats - ? 9734 Product Safety 19 7783-28-0 2000 Limit test TFI/EFMA Laboratories diammonium phosphate

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 13/01/2016 12 Sour

Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year 8.2 Eye Irritation [unknown] OECD 437 - BCOP bovine eyes FARM: co-owned 19 7783-28-0 [unknown] diammonium hydrogenorthophosphate C.M. Verspeek-Rip 8.5.2 Acute inhalation toxicity [unknown] Acute inhalation toxicity in rats rats FARM co-owned Drs. 19 7783-28-0 A.H.B.M. van [unknown] Huygevoort (2010 diammonium hydrogenorthophosphate 9.1.4 Activated sludge respiration inhibition Desmares-Koopmans OECD 209 - ASRI Co-owner; can be 19 7783-28-0 2010 diammonium hydrogenorthophosphate testing M.J.E. used for all purposes. 8.3 Skin sensitisation van Otterdijk F.M OECD 429 - LLNA mice 493657 19 7783-28-0 2010 Notox B.V. diammonium hydrogenorthophosphate 9.1.2 Short-term toxicity to fish [not known] OECD 203 - Acute toxicity to fish FISH [unknown] (static) 19 7783-28-0 2016 IP Consortium Envigo diammonium hydrogenorthophosphate 9.1.1 Short-term toxicity to aquatic invertebrates [not known] OECD 202 - Acute toxicity to Daphnia Daphnia [unknown] 19 7783-28-0 2016 magna IP Consortium Envigo diammonium hydrogenorthophosphate 9.1.1 Short term toxicity testing on invertebrates Dr. H. Lebertz Acute toxicity Daphnia Daphnia 98TE181171 20 14728-39-3 1999 B44 Fresenius ammonium polyphosphate 8.5.1 Acute oral toxicity Cuthbert JA AMGARD LR2: Acute toxicity (LD50) rat Inveresk Research Int. (for IRI-5910 20 68333-79-9 1990 AW_1990a ammonium polyphosphate test in rats A&W) 8.5.3 Acute dermal toxicity Cuthbert JA AMGARD LR2: Acute dermal rabbit Inveresk Research Int. (for IRI-5915 20 68333-79-9 1990 AW_1990b ammonium polyphosphate irritation test in rabbits A&W) 8.3 Skin sensitisation Tomlinson PP OECD 406 - M&K Guinea pigs 71/154 20 68333-79-9 1993 AW_1993a Safepharm (for A&W) ammonium polyphosphate 8.5.1 Acute oral toxicity Guest RL OECD 420 - Acute oral toxicity rat 71/160 20 68333-79-9 1993 AW_1993c Safepharm (for A&W) ammonium polyphosphate 8.2 Eye Irritation Tomlinson PP OECD 405 rabbit 71/155 20 68333-79-9 1993 AW_1993b Safepharm (for A&W) ammonium polyphosphate 8.5.3 Acute dermal toxicity Guest RL OECD 402 - Acute dermal rat 71/161 20 68333-79-9 1993 AW_1993d Safepharm (for A&W) ammonium polyphosphate 8.3 Skin sensitisation Tomlinson PP OECD 406 - M&K Guinea pigs 71/162 20 68333-79-9 1993 AW_1993e Safepharm (for A&W) ammonium polyphosphate 8.5.3 Acute dermal toxicity Tomlinson PP OECD 402 - Acute dermal rabbit 71/163 20 68333-79-9 1993 AW_1993f Safepharm (for A&W) ammonium polyphosphate 8.2 Eye Irritation Tomlinson PP OECD 405 rabbit 71/164 20 68333-79-9 1993 AW_1993g Safepharm (for A&W) ammonium polyphosphate 8.5.2 Acute inhalation toxicity Tomlinson PP OECD 436 - Acute inhalation rat 71/167 20 68333-79-9 1993 AW_1993h Safepharm (for A&W) ammonium polyphosphate 8.5.3 Acute dermal toxicity Snell K OECD 402 - Acute dermal rat 71/320 20 68333-79-9 1994 AW_1994 Safepharm (for A&W) ammonium polyphosphate 8.4.1 In vitro gene mutation study in bacteria Thompson PW OECD 471 - AMES Salmonella 071/385 20 68333-79-9 1995 typhimurium AW_1995 Safepharm (for A&W) ammonium polyphosphate 8.3 Skin sensitisation Cutherbert JA and Three flame retardant formulations. human Inveresk Research Int. (for IRI: 591521 20 68333-79-9 1996 AW_1996 ammonium polyphosphate Neilson L A human skin patch test (46h A&W) 9.1.3 Short-term toxicity testing on fish ? OECD 203 (static) fish: Rainbow Product Safety 9736 20 68333-79-9 2000 TFI/EFMA Liquid ammonium polyphosphate trout Laboratories 8.5.1 Acute oral toxicity ? Acute oral toxicity up and down ? Product Safety 9735 20 68333-79-9 2000 TFI/EFMA Liquid ammonium polyphosphate procedure in rats Laboratories

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 13/01/2016 13 Sour

Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year 8.5.1 Acute oral toxicity Birch M.D. single oral dose Rats Y-73-113 21 7758-23-8 1973 BK26 Younger Lab monocalcium Phosphate 8.5.3 Acute dermal toxicity Birch M.D. acute skin absorption minimal lethal Rabbits Y-73-113 21 7758-23-8 1973 BK26 Younger Lab monocalcium Phosphate dose 8.1 Skin irritation Birch M.D. In vivo skin irritation - rabbits Rabbits Y-73-113 21 7758-23-8 1973 BK26 Younger Lab monocalcium Phosphate 8.2 Eye Irritation Birch M.D. Eye irritation rabbits Rabbits Y-73-113 21 7758-23-8 1973 BK26 Younger Lab monocalcium Phosphate 8.5.1 Acute oral toxicity Bullock CH and Toxicology lab report rat T-4054 21 7758-23-8 1972 PS-2865 Stauffer Western RC monocalcium phosphate Kamienski FX. 8.1 Skin irritation Bullock CH and In vivo skin irritation - rabbits rabbit T-4054 21 7758-23-8 Kamienski FX. 1972 PS-2865 Stauffer Western RC monocalcium phosphate monocalcium phosphate 21 7758-23-8 8.5.1 Acute oral toxicity Sorenson S 1985 Acute toxicity test battery for rat PS-2815 Stauffer Western RC T-12163 8.5.3 Acute dermal toxicity Sorenson S Acute toxicity test battery for rabbit T-12164 21 7758-23-8 1985 PS-2815 Stauffer Western RC monocalcium phosphate monocalcium phosphate anhydrous 8.1 Skin irritation Sorenson S Acute toxicity test battery for rabbit T-12165 21 7758-23-8 1985 PS-2815 Stauffer Western RC monocalcium phosphate monocalcium phosphate anhydrous 8.2 Eye Irritation Sorenson S Acute toxicity test battery for rabbit T-12166 21 7758-23-8 1985 PS-2815 Stauffer Western RC monocalcium phosphate monocalcium phosphate anhydrous 8.1 Skin irritation Henderson L and In vivo skin irritation - rabbits rabbit T-4984 21 7758-23-8 1974 PS-2894 Stauffer Western RC monocalcium phosphate Joiner RL 8.8.1 Toxicokinetics Killenger JM Calcium phosphates, calcium sulfate rat T-11722 21 7758-23-8 1986 PS-2967 Stauffer Western RC monocalcium phosphate and calcium carbonate bioavailability Calcium bis(dihydrogenorthophosphate) / monocalcium 7.2 Melting/freezing point O'Connor B A6 Melting/Freezing Temperature N/A 2920/0011 21 7758-23-8 2009 IP Consortium Harlan phosphate 7.7 Water solubility O'Connor B A6 Water Solubility N/A 2920/0011 21 7758-23-8 2009 IP Consortium Harlan Calcium bis(dihydrogenorthophosphate) / monocalcium phosphate Calcium bis(dihydrogenorthophosphate) / monocalcium 8.2 Eye Irritation Warren N Reconstructed Human Corneal in vitro tissues 2920/0094 21 7758-23-8 2009 IP Consortium Harlan phosphate Model Calcium bis(dihydrogenorthophosphate) / monocalcium 8.2 Eye Irritation Bradshaw J OECD 405 - Acute eye irritation rabbit 2920/0127 21 7758-23-8 2010 IP Consortium Harlan phosphate 8.5.2 Acute inhalation toxicity Schuler D OECD 436 - Acute inhalation rat C92120 Calcium bis(dihydrogenorthophosphate) / monocalcium 21 7758-23-8 2010 IP Consortium Harlan phosphate Calcium bis(dihydrogenorthophosphate) / monocalcium 9.1.4 Toxicity to microorganisms Simon M OECD 209 - ASRI sludge BUD-008/4-06 21 7758-23-8 2015 Budenheim Fraunhofer IME phosphate microorganisms dicalcium phosphate 22 7757-93-9 8.5.1 Acute oral toxicity Birch M.D. 1974 single oral dose Rats BK27 Younger Lab Y-74-225 dicalcium phosphate 22 7757-93-9 8.5.3 Acute dermal toxicity Birch M.D. 1974 acute skin absorption minimal lethal Rabbits BK27 Younger Lab Y-74-225 dicalcium phosphate 22 7757-93-9 8.1 Skin irritation Birch M.D. 1974 In vivo skin irritation - rabbits Rabbits BK27 Younger Lab Y-74-225 dicalcium phosphate 22 7757-93-9 8.2 Eye Irritation Birch M.D. 1974 Eye irritation rabbits Rabbits BK27 Younger Lab Y-74-225 dicalcium phosphate 22 7757-93-9 8.5.1 Acute oral toxicity Birch M.D. 1973 single oral dose Rats BK28 Younger Lab Y-73-50 dicalcium phosphate 22 7757-93-9 8.5.3 Acute dermal toxicity Birch M.D. 1973 acute skin absorption minimal lethal Rabbits BK28 Younger Lab Y-73-50 dicalcium phosphate 22 7757-93-9 8.1 Skin irritation Birch M.D. 1973 In vivo skin irritation - rabbits Rabbits BK28 Younger Lab Y-73-50 dicalcium phosphate 22 7757-93-9 8.2 Eye Irritation Birch M.D. 1973 Eye irritation rabbits Rabbits BK28 Younger Lab Y-73-50 dicalcium phosphate 22 7757-93-9 8.5.1 Acute oral toxicity Kamienski FX 1970 toxicity studies on dicalcium Rat PS-2800 Stauffer Western RC T-1624 dicalcium phosphate 22 7757-93-9 8.5.1 Acute oral toxicity Kamienski FX 1970 toxicity studies on dicalcium Rat PS-2800 Stauffer Western RC T-1624 dicalcium phosphate 22 7757-93-9 8.1 Skin irritation Bullock CH and 1972 In vivo skin irritation - rabbits rabbit PS-2860 Stauffer Western RC T-1861 dicalcium phosphate 22 7757-93-9 8.8.1 Toxicokinetics Killenger JM 1986 Calcium phosphates, calcium sulfate rat PS-2967 Stauffer Western RC T-11722 calcium hydrogenorthophosphate / Dicalcium phosphate 22 7757-93-9 7.2 Melting/freezing point Butler RE 2009 A6 Melting/Freezing Temperature N/A IP Consortium Harlan 2920/0012 calcium hydrogenorthophosphate / Dicalcium phosphate 22 7757-93-9 7.7 Water solubility Butler RE 2009 A6 Water Solubility N/A IP Consortium Harlan 2920/0012 calcium hydrogenorthophosphate / Dicalcium phosphate 22 7757-93-9 8.2 Eye Irritation Warren N 2009 Reconstructed Human Corneal Model in vitro tissues IP Consortium Harlan 2920/0013

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 13/01/2016 14 Sour

Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year calcium hydrogenorthophosphate 22 7757-93-9 8.5.1 Acute oral toxicity Unknown 2006/20 OECD 401 - Acute oral toxicity unknown unknown Korean Ministry of [unknown] calcium hydrogenorthophosphate 22 7757-93-9 8.4.1 In vitro gene mutation study in bacteria Unknown 2006/20 In vitro genen mutation in bacteria unknown unknown Korean Ministry of [unknown] calcium hydrogenorthophosphate 22 7757-93-9 8.4.2 In vitro cytogenicity study in mammalian cells Unknown 2006/20 In vitro chromosomal abberation unknown unknown Korean Ministry of [unknown] calcium hydrogenorthophosphate 22 7757-93-9 9.1.3 Short-term toxicity testing on fish Unknown 2006/20 Aquatic toxicity to fish (OECD ?) unknown unknown Korean Ministry of [unknown] 9.1.1 Short term toxicity testing on invertebrates Unknown 2006/20 Aquatic toxicity to invertebrates unknown Korean Ministry of [unknown] 22 7757-93-9 unknown calcium hydrogenorthophosphate 08 (OECD ?) Environment dicalcium phosphate (90%), plus 10% MCP 22 7757-93-9 8.2 Eye Irritation Lowe C 2011 Eye irritation in vivo Rabbit ICLPP Eurofins 31519 dicalcium phosphate (97%), plus 3% MCP 22 7757-93-9 8.2 Eye Irritation Durando J 2011 Eye irritation in vivo Rabbit ICLPP Eurofins 31321 Tricalcium bis(orthophosphate) 23 7758-87-4 7.2 Melting/freezing point Butler RE 2009 A6 Melting/Freezing Temperature N/A IP Consortium Harlan 2920/0014 7.7 Water solubility Butler RE A6 Water Solubility N/A 2920/0014 23 7758-87-4 2009 IP Consortium Harlan Tricalcium bis(orthophosphate) 8.2 Eye Irritation Warren N Reconstructed Human Corneal Model in vitro tissues 2920/0017 23 7758-87-4 2009 IP Consortium Harlan Tricalcium bis(orthophosphate) 8.1 Skin irritation Butler RE OECD 439 - In vitro skin irritancy in vitro tissues 2920/0016 23 7758-87-4 2009 (B.46) IP Consortium Harlan Tricalcium bis(orthophosphate) 8.1 Skin corrosion Warren N OECD 431 - In vitro skin corrosion in vitro tissues 2920/0068 23 7758-87-4 2009 IP Consortium Harlan Tricalcium bis(orthophosphate) 8.5.1 Acute oral toxicity Bradshaw J OECD 420 - Acute oral toxicity Rat 2920/0015 23 7758-87-4 2009 IP Consortium Harlan Tricalcium bis(orthophosphate) Tricalcium bis(orthophosphate) 23 7758-87-4 8.2 Eye Irritation Bradshaw J 2010 OECD 405 - Acute eye irritation Rabbit IP Consortium Harlan 2920/0128 tricalcium bis(orthophosphate) 23 7758-87-4 8.4.3 In vitro gene mutation study in mammalian Unknown 2005 in vitro mammalian mouse unknown unknown Korean Ministry of [unknown] tricalcium bis(orthophosphate) 23 7758-87-4 9.1.3 Short-term toxicity testing on fish Unknown 2005 Aquatic toxicity to fish (OECD ?) unknown unknown Korean Ministry of [unknown] 24 1306-06-5 8.1 Skin irritation Freeman C 1993 In vivo skin irritation - rabbits Rabbits F32 FMC I 93-1753 Tricalcium phosphate 24 7758-87-4 8.5.1 Acute oral toxicity Bullock CH and 1972 Toxicology lab report rat PS-2865 Stauffer Western RC T-4054 Tricalcium phosphate 24 1306-06-5 8.5.1 Acute oral toxicity Foster TL 1985 Toxicology lab report rat PS-2957 Stauffer Western RC T-10619 Tricalcium phosphate 24 1306-06-5 8.5.3 Acute dermal toxicity Foster TL 1985 Toxicology lab report rabbit PS-2957 Stauffer Western RC T-10619 Tricalcium phosphate 24 1306-06-5 8.1 Skin irritation Foster TL 1985 In vivo skin irritation - rabbits rabbit PS-2957 Stauffer Western RC T-10619 Tricalcium phosphate 24 1306-06-5 8.2 Eye Irritation Foster TL 1985 Toxicology lab report - in vivo rabbit PS-2957 Stauffer Western RC T-10619 tricalcium phosphate 24 1306-06-5 8.1 Skin irritation Bullock CH and 1972 In vivo skin irritation - rabbits rabbit PS-2860 Stauffer Western RC T-1861 tricalcium phosphate 24 1306-06-5 8.8.1 Toxicokinetics Killenger JM 1986 Calcium phosphates, calcium sulfate rat PS-2967 Stauffer Western RC T-11722 tricalcium phosphate 24 12167-74-7 7.7 Water solubility Butler RE 2009 A6 Water Solubility N/A IP Consortium Harlan 2920/0018 tricalcium phosphate 24 12167-74-7 8.4.3 In vitro gene mutation study in mammalian Flanders L 2009 OECD 476 - Mouse Lymphoma Assay Murine cells IP Consortium Harlan 2920/0079 Pentacalcium hydroxide tris(orthophosphate) 24 12167-74-7 8.5.2 Acute inhalation toxicity Veiga S 2015 OECD 436 - Acute inhalation rat Budenheim Vivotechnia B-01994 Pentacalcium hydroxide tris(orthophosphate) 24 12167-74-7 8.5.2 Acute inhalation toxicity Veiga S 2015 OECD 436 - Acute inhalation rat Budenheim Vivotechnia B-02035 Pentacalcium hydroxide tris(orthophosphate) 24 12167-74-7 8.4.1 In vitro gene mutation study in bacteria Kolp N 2015 OECD 471 - AMES n/a Budenheim Bioserv 61948-20-132-2014030824 Pentacalcium hydroxide tris(orthophosphate) 24 12167-74-7 8.4.3 In vitro gene mutation study in mammalian Prietzsch H 2015 OECD 487 - In vitro mouse CHL fibroblasts V- Budenheim Bioserv 61878-20-146-2014030824 Pentacalcium hydroxide tris(orthophosphate) 24 12167-74-7 8.3 Skin sensitisation Grummer B 2014 OECD 406 - M&K guinea pig Budenheim BIOSERV Project 108171187 calcium dihydrogenpyrophosphate 25 14866-19-4 9.2.2.1 Hydrolysis as a function of pH O'Connor B 2009 Hydrolysis as a function of pH N/A IP Consortium Harlan 2920/0048 calcium dihydrogenpyrophosphate 25 14866-19-4 7.7 Water solubility Walker J 2009 A6 Water Solubility N/A IP Consortium Harlan 2920/0048 8.2 Eye Irritation Durando J Eye irritation in vivo Rabbit 31319 Calcium acid pyrophosphate (66-79%), 16-24% MCP, 4-9% 25 14866-19-4 2011 ICLPP Eurofins DCP, 1% TCP Calcium dihydrogenpyrophosphate 25 14866-19-4 8.1 Skin irritation Warren N 2011 OECD 431 - In vitro skin corrosion EPISKIN IP Consortium Harlan 2920/0151 calcium pyrophosphate 25 14866-19-4 8.5.1 Acute oral toxicity Bradshaw J 2013 OECD 420 - Acute oral toxicity RAT IP Consortium Harlan 41205112 8.1 Skin irritation Warren N OECD 439 - In vitro skin irritancy RHE tissues 41205113 25 14866-19-4 2013 IP Consortium Harlan calcium pyrophosphate (B.46) 8.2 Eye Irritation Prietzch H OECD 405 rabbit 58988-20-133-2013070544 25 14866-19-4 2014 Budenheim BIOSERV calcum dihydrogenpyrophosphate 8.5.1 Acute oral toxicity Birch M.D. single oral dose Rats Y-73-116 26 7790-76-3 1973 BK29 Younger Lab calcium pyrophosphate 8.5.3 Acute dermal toxicity Birch M.D. acute skin absorption minimal lethal Rabbits Y-73-116 26 7790-76-3 1973 BK29 Younger Lab calcium pyrophosphate dose

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 13/01/2016 15 Sour

Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year 8.1 Skin irritation Birch M.D. In vivo skin irritation - rabbits Rabbits Y-73-116 26 7790-76-3 1973 BK29 Younger Lab calcium pyrophosphate 8.2 Eye Irritation Birch M.D. Eye irritation rabbits Rabbits Y-73-116 26 7790-76-3 1973 BK29 Younger Lab calcium pyrophosphate 8.1 Skin irritation Henderson L and In vivo skin irritation - rabbits rabbit T-4895 26 7790-76-3 1974 PS-2883 Stauffer Western RC calcium pyrophosphate Joiner RL 7.2 Melting/freezing point Walker J A6 Melting/Freezing Temperature N/A 2920/0049 26 7790-76-3 2009 IP Consortium Harlan Dicalcium pyrophosphate Dicalcium pyrophosphate 26 7790-76-3 7.7 Water solubility Walker J 2009 A6 Water Solubility N/A IP Consortium Harlan 2920/0049 Dicalcium pyrophosphate 26 7790-76-3 8.1 Skin corrosion Warren N 2011 OECD 431 - In vitro skin corrosion N/A IP Consortium Harlan 2920/0152 dicalcium pyrophosphate 26 7790-76-3 8.5.1 Acute oral toxicity Nixon G 1966 Acute oral toxicity Rat P&G IP26 P&G MV-204 8.5.1 Acute oral toxicity Bradshaw J OECD 420 - Acute oral toxicity RAT 41205114 26 7790-76-3 2013 IP Consortium Harlan dicalcium pyrophosphate dicalcium pyrophosphate 26 7790-76-3 8.1 Skin irritation Warren N 2013 OECD 439 - In vitro skin irritancy RHE tissues IP Consortium Harlan 41205115 dicalcium pyrophosphate 26 7790-76-3 8.2 Eye Irritation Warren N 2013 OECD 437 - BCOP bovine eyes IP Consortium Harlan 41205116 dicalcium pyrophosphate 26 7790-76-3 8.2 Eye Irritation Bradshaw J 2012 OECD 405 - Acute eye irritation rabbit IP Consortium Harlan 41205117 dicalcium pyrophosphate 26 7790-76-3 8.5.2 Acute inhalation toxicity Veiga S 2015 OECD 436 - Acute inhalation rat Budenheim Vivotechnia B-01992 8.3 Skin sensitisation Grummer B OECD Guideline 406 - Guinea Pig guinea pig 61947-20-147-2014030823 26 7790-76-3 2014 Budenheim Bioserv dicalcium pyrophosphate Maximization Test (GPMT) dicalcium pyrophosphate 26 7790-76-3 8.4.1 In vitro gene mutation study in bacteria Kolp N 2015 OECD 471 - AMES n/a Budenheim Bioserv 61947-20-132-2014030823 dicalcium pyrophosphate 26 7790-76-3 8.4.2 In vitro micronucleus Prietzsch H 2015 OECD 487 - In vitro mouse CHL fibroblasts V- Budenheim Bioserv 61947-20-146-2014030823 dicalcium pyrophosphate 26 7790-76-3 8.4.3 In vitro gene mutation study in mammalian Kolp N 2015 OECD 476 - Mouse Lymphoma assay mouse Budenheim Bioserv 61947-20-153-2014030823 7.4 Density Wagner V OECD 109 - Relative density N/A Project 108161182 Dicalcium pyrophosphate 26 7790-76-3 2015 Budenheim Ibacon GmbH Dicalcium pyrophosphate 26 7790-76-3 7.10 Flammability Wagner V 2015 A.10 Determination of flammability N/A Budenheim Ibacon GmbH Project 108161187 Dicalcium pyrophosphate 26 7790-76-3 7.12 Self-ignition Wagner V 2015 A.16 Determination of the relative N/A Budenheim Ibacon GmbH Project 108161188 Dicalcium pyrophosphate 26 7790-76-3 7.14 Particle size distribution Ahrens A 2016 OECD 110 - Particle Size Distribution N/A Budenheim Ibacon GmbH [not provided by sponsor] iron orthophosphate 27 10045-86-0 8.5.1 Acute oral toxicity Bullock CH and 1972 Toxicology lab report rat PS-2865 Stauffer Western RC T-4054 8.1 Skin irritation Bullock CH and In vivo skin irritation - rabbits rabbit T-1861 27 10045-86-0 Kamienski FX 1972 PS-2860 Stauffer Western RC ferric orthophosphate 7.2 Melting/freezing point Walker J A6 Melting/Freezing Temperature N/A 2920/0022 27 10045-86-0 2009 IP Consortium Harlan iron orthophosphate 7.7 Water solubility Walker J A6 Water Solubility N/A 2920/0022 27 10045-86-0 2009 IP Consortium Harlan iron orthophosphate iron orthophosphate 27 10045-86-0 7.4 Relative Density Walker J 2011 OECD 109 - Relative density N/A IP Consortium Harlan 41101362 iron orthophosphate 27 10045-86-0 9.1.4 Activated sludge respiration inhibition Clarke N 2011 OECD 209 - ASRI STP organisms IP Consortium Harlan 41101366 iron orthophosphate 27 10045-86-0 8.5.2 Acute inhalation toxicity Griffiths DR 2011 OECD 436 - Acute inhalation Rat IP Consortium Harlan 41101363 iron orthophosphate 27 10045-86-0 8.3 Skin sensitisation Bradshaw J 2011 OECD 429 - LLNA Mouse IP Consortium Harlan 41101364 iron orthophosphate 27 10045-86-0 8.4.3 In vitro gene mutation study in mammalian Brown RW 2011 OECD 476 - Mouse Lymphoma Assay Mouse cells IP Consortium Harlan 41101365 iron orthophosphate 27 10045-86-0 8.5.1 Acute oral toxicity Bradshaw J 2011 OECD 420 - Acute oral toxicity rat IP Consortium Harlan 41103492 iron orthophosphate 27 10045-86-0 8.1 Skin corrosion Warren N 2011 OECD 431 - In vitro skin corrosion tissues IP Consortium Harlan 41103494 iron orthophosphate 27 10045-86-0 8.1 Skin irritation Warren N 2011 OECD 439 - In vitro skin irritancy tissues IP Consortium Harlan 41103493 iron orthophosphate 27 10045-86-0 8.2 Eye Irritation Warren N 2011 Reconstructed Human Corneal Model tissues IP Consortium Harlan 41103495 iron orthophosphate 27 10045-86-0 8.2 Eye Irritation Bradshaw J 2011 ex-vivo REET ex-vivo rabbit IP Consortium Harlan 41103495 iron orthophosphate 27 10045-86-0 8.2 Eye Irritation Bradshaw J 2011 OECD 405 - Acute eye irritation rabbit IP Consortium Harlan 41103496 iron orthophosphate 27 10045-86-0 9.1.2 Growth inhibition study in aquatic plants Vryenhoel H 2011 OECD 201 - Algal growth inhibition algae IP Consortium Harlan 41103497 iron orthophosphate /NEU 1165M (iron (III) phosphate) 27 10045-86-0 8.5.3 Acute dermal toxicity Untenwiehe M 1996 Assesment of Dermal toxicity with Rat Neudorff NOTOX 154878 iron orthophosphate /NEU 1165M (iron (III) phosphate) 27 10045-86-0 8.2 Eye Irritation [not known] Eye irritation in vivo Rabbit Neudorff NOTOX 154891 iron orthophosphate /NEU 1165M (iron (III) phosphate) 27 10045-86-0 8.5.1 Acute oral toxicity [not known] Acute oral toxicty Rat Neudorff NOTOX 154867 iron orthophosphate /NEU 1165M (iron (III) phosphate) 27 10045-86-0 9.6.1 Long-term or reproductive toxicity to birds [not known] Acute toxicity to birds birds Neudorff NOTOX 154902 iron orthophosphate /NEU 1165M (iron (III) phosphate) 27 10045-86-0 9.4.1. Acute toxicty to soil invertebrates [not known] Acute toxicty to soil invertebrates beetle Neudorff Arbeitsgemeinschaft 95155-01-NLAb iron orthophosphate /NEU 1165M (iron (III) phosphate) 27 10045-86-0 9.4.1. Acute toxicty to soil invertebrates [not known] Acute toxicty to soil invertebrates beetle Neudorff Arbeitsgemeinschaft 9803-01 iron orthophosphate /NEU 1165M (iron (III) phosphate) 27 10045-86-0 7.10 Flammability Untenwiehe M 1996 Flammability N/A Neudorff NOTOX 15845 iron orthophosphate /NEU 1165M (iron (III) phosphate) 27 10045-86-0 8.1 Skin irritation [not known] Primary skin irritation Rabbit Neudorff NOTOX 154889 iron orthophosphate / Ferric phosphate 27 10045-86-0 8.1 Skin irritation Berndt A 2000 Primary skin irritation / corrosion Rabbit Neudorff NOTOX 287426

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 13/01/2016 16 Sour

Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year iron orthophosphate /NEU 1165M (iron (III) phosphate) 27 10045-86-0 9.4.1. Acute toxicty to soil invertebrates [not known] Acute toxicty to soil invertebrates Neudorff Arbeitsgemeinschaft 95155-01-NLPc iron orthophosphate / Eisen (III)-phosphate (ferric(III) 27 10045-86-0 9.1.5. Long-term toxicity to Daphnia Heintze A 1997 Long-term toxicity to Daphnia Daphnia magna Neudorff Arbeitsgemeinschaft 97241/01-AADm iron orthophosphate / Eisen (III)-phosphate (ferric(III) 27 10045-86-0 9.1.3 Short-term toxicity testing on fish Heintze A 1997 Short-term toxicity testing on fish fish: rainbow Neudorff Arbeitsgemeinschaft 9724/-01-AAOm iron orthophosphate / Eisen (III)-phosphate (ferric(III) 9.1.2 Growth inhibition study in aquatic plants Dengler D Growth inhibition study in aquatic Green algae 97241/01-AASs 27 10045-86-0 1997 Neudorff Arbeitsgemeinschaft phosphate . 4H20) plants 8.5.1 Acute oral toxicity Berndt A Assessment of acute oral toxicity Rat 272982 27 10045-86-0 1999 with Ferric phosphate in the rat Neudorff NOTOX Ferric phosphate (acute toxic class method) 8.2 Eye Irritation Berndt A Eye irritation / corrosion in vivo Rabbit 287437 27 10045-86-0 2000 Neudorff NOTOX Ferric phosphate 7.7 Water solubility Klawonn Th OECD 105 - Water solubility N/A BUD-007/1-34 27 10045-86-0 2015 Budenheim Fraunhofer IME Ferric phosphate Ferric phosphate 27 10045-86-0 Transformation / dissolution protocol Klawonn Th 2016 OECD 29 - Determination of the N/A Budenheim Fraunhofer IME BUD-007/5-51 Ferric phosphate 27 10045-86-0 8.4.1 In vitro gene mutation in bacterial cells Spruth B 2016 OECD 471 - AMES N/A Budenheim LPT 32877 8.4.2 In vitro micronucleus Spruth B OECD 487 - In vitro mouse N/A 32878 27 10045-86-0 2016 micronucleus Budenheim LPT Ferric phosphate Tetrairon tris(pyrophosphate) 28 10058-44-3 7.2 Melting/freezing point Walker J 2009 A6 Melting/Freezing Temperature N/A IP Consortium Harlan 2920/0050 Tetrairon tris(pyrophosphate) 28 10058-44-3 7.7 Water solubility Walker J 2009 A6 Water Solubility N/A IP Consortium Harlan 2920/0050 tetrairon tris(pyrophosphate) 28 10058-44-3 7.4 Relative Density [not provided by 2012 Relative density n/a BKG BKG email tetrairon tris(pyrophosphate) 28 10058-44-3 8.5.1 Acute oral toxicity Bradshaw J 2012 OECD 420 - Acute oral toxicity Rat IP Consortium Harlan 41201540 tetrairon tris(pyrophosphate) 28 10058-44-3 8.5.2 Acute inhalation toxicity Griffiths D 2012 OECD 436 - Acute inhalation Rat IP Consortium Harlan 41201541 tetrairon tris(pyrophosphate) 28 10058-44-3 8.1 Skin corrosion Warren N 2012 OECD 431 - In vitro skin corrosion tissues IP Consortium Harlan 41201542 tetrairon tris(pyrophosphate) 28 10058-44-3 8.1 Skin irritation Warren N 2012 OECD 439 - In vitro skin irritancy RHE tissues IP Consortium Harlan 41201543 tetrairon tris(pyrophosphate) 28 10058-44-3 8.2 Eye Irritation Warren N 2012 OECD 437 - BCOP bovine eyes IP Consortium Harlan 41201544 tetrairon tris(pyrophosphate) 28 10058-44-3 8.2 Eye Irritation Bradshaw J 2012 OECD 405 - Acute eye irritation rabbit IP Consortium Harlan 41201545 Dimagnesium phosphate-3-hydrate 29 7757-86-0 7.2 Melting/freezing point O'Connor B 2009 A6 Melting/Freezing Temperature N/A IP Consortium Harlan 2920/0019 Dimagnesium phosphate-3-hydrate 29 7757-86-0 7.7 Water solubility O'Connor B 2009 A6 Water Solubility N/A IP Consortium Harlan 2920/0019 Dimagnesium phosphate-3-hydrate 29 7757-86-0 8.2 Eye Irritation Warren N 2009 Reconstructed Human Corneal Model in vitro tissues IP Consortium Harlan 2920/0091 Dimagnesium phosphate-3-hydrate 29 7757-86-0 8.1 Skin irritation Warren N 2009 OECD 439 - In vitro skin irritancy in vitro tissues IP Consortium Harlan 2920/0090 Dimagnesium phosphate-3-hydrate 29 7757-86-0 8.1 Skin corrosion Warren N 2009 OECD 431 - In vitro skin corrosion in vitro tissues IP Consortium Harlan 2920/0089 Dimagnesium phosphate-3-hydrate 29 7757-86-0 8.5.1 Acute oral toxicity Bradshaw J 2009 OECD 420 - Acute oral toxicity Rat IP Consortium Harlan 2920/0088 trimagnesium phosphate 30 7757-87-1 8.5.1 Acute oral toxicity Birch M.D. 1975 single oral dose Rats BK30 Younger Lab Y-75-182 trimagnesium phosphate 30 7757-87-1 8.5.3 Acute dermal toxicity Birch M.D. 1975 acute skin absorption minimal lethal Rabbits BK30 Younger Lab Y-75-182 trimagnesium phosphate 30 7757-87-1 8.1 Skin irritation Birch M.D. 1975 In vivo skin irritation - rabbits Rabbits BK30 Younger Lab Y-75-182 trimagnesium phosphate 30 7757-87-1 8.2 Eye Irritation Birch M.D. 1975 Eye irritation rabbits Rabbits BK30 Younger Lab Y-75-182 trimagnesium phosphate 30 7757-87-1 8.1 Skin irritation Bullock CH and 1972 In vivo skin irritation - rabbits rabbit PS-2860 Stauffer Western RC T-1861 Trimagnesium phosphate-4-hydrate 30 7757-87-1 7.2 Melting/freezing point Walker J 2009 A6 Melting/Freezing Temperature N/A IP Consortium Harlan 2920/0020 Trimagnesium phosphate-4-hydrate 30 7757-87-1 7.7 Water solubility Walker J 2009 A6 Water Solubility N/A IP Consortium Harlan 2920/0020 Trimagnesium phosphate-4-hydrate 30 7757-87-1 8.4.1 In vitro gene mutation study in bacteria Thompson PW 2009 OECD 471 - AMES salmonella IP Consortium Harlan 2920/0080 Trimagnesium phosphate-4-hydrate 30 7757-87-1 8.4.2 In vitro cytogenicity study in mammalian cells Bowles A 2009 OECD 473 - Chrom Ab human IP Consortium Harlan 2920/0081 Trimagnesium phosphate-4-hydrate 30 7757-87-1 8.4.3 In vitro gene mutation study in mammalian Flanders L 2009 OECD 476 - Mouse Lymphoma Assay Mouse cell line IP Consortium Harlan 2920/0082 trimagnesium bis(orthophosphate) 30 7757-87-1 8.1 Skin irritation Warren N 2012 OECD 439 - In vitro skin irritancy RHE tissues IP Consortium Harlan 41200861 trimagnesium bis(orthophosphate) 30 7757-87-1 8.2 Eye Irritation Warren N 2012 OECD 437 - BCOP bovine eyes IP Consortium Harlan 41200862 trimagnesium bis(orthophosphate) 30 7757-87-1 8.2 Eye Irritation Bradshaw J 2012 OECD 405 - Acute eye irritation Rabbit IP Consortium Harlan 41200863 trimagnesium bis(orthophosphate) 30 7757-87-1 8.5.1 Acute oral toxicity Bradshaw J 2013 OECD 420 - Acute oral toxicity RAT IP Consortium Harlan 41206486 monomagnesium phosphate (solution) 31 13092-66-5 8.5.1 Acute oral toxicity Bullock CH and 1972 Toxicology lab report rat PS-2865 Stauffer Western RC T-4054 monomagnesium phosphate (solution) 31 13092-66-5 8.1 Skin irritation Bullock CH and 1972 In vivo skin irritation - rabbits rabbit PS-2865 Stauffer Western RC T-4054 monomagnesium phosphate (solution) 31 13092-66-5 8.5.1 Acute oral toxicity Joiner RL 1975 Toxicology lab report rat PS-2918 Stauffer Western RC T-5594 monomagnesium phosphate (solution) 31 13092-66-5 8.1 Skin irritation Joiner RL 1975 In vivo skin irritation - rabbits rabbit PS-2918 Stauffer Western RC T-5594 magnesium phosphate (liquid) 31 10392-66-5 8.1 Skin corrosion Nitka S 1979 DOT skin corrosion in rabbits rabbit PS-3713 Consumer product testing M2270-79 Magnesium phosphate (solution) 31 10392-66-5 8.5.1 Acute oral toxicity ? 1981 The acute oral toxicity of magnesium rat PS-3714 Mobil M1171-81 Magnesium phosphate (solution) 31 10392-66-5 8.5.3 Acute dermal toxicity ? 1981 The acute dermal toxicity of rabbit PS-3714 Mobil M1171-81 Magnesium phosphate (solution) 31 10392-66-5 8.2 Eye Irritation ? 1981 Primary eye irritation of magnesium rabbit PS-3714 Mobil M1171-81 Magnesium phosphate (solution) 31 10392-66-5 8.1 Skin irritation ? 1981 Skin irritation of magnesium rabbit PS-3714 Mobil M1171-81

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 13/01/2016 17 Sour

Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year 8.5.1 Acute oral toxicity Kamienski FX Toxicology lab report rat T-1680 31 13092-66-5 1971 PS-2839 Stauffer Western RC Magnesium phosphate (solution) 8.5.3 Acute dermal toxicity Kamienski FX Toxicology lab report rabbit T-1680 31 13092-66-5 1971 PS-2839 Stauffer Western RC Magnesium phosphate (solution) Magnesium phosphate (solution) 31 13092-66-5 8.1 Skin irritation Kamienski FX 1971 In vivo skin irritation - rabbits rabbit PS-2839 Stauffer Western RC T-1680 Magnesium phosphate (solution) 31 13092-66-5 8.2 Eye Irritation Kamienski FX 1971 Toxicology lab report rabbit PS-2839 Stauffer Western RC T-1680 Magnesium bis(dihydrogenorthophosphate) 31 13092-66-5 7.2 Melting/freezing point O'Connor B 2009 A6 Melting/Freezing Temperature N/A IP Consortium Harlan 2920/0021 Magnesium bis(dihydrogenorthophosphate) 31 13092-66-5 7.7 Water solubility O'Connor B 2009 A6 Water Solubility N/A IP Consortium Harlan 2920/0021 Magnesium bis(dihydrogenorthophosphate) 31 13092-66-5 7.4 Relative Density Woolley A 2012 OECD 109 - Relative density n/a IP Consortium Harlan 41205081 8.5.1 Acute oral toxicity Bradshaw J OECD 420 - Acute oral toxicity rat 41205082 31 13092-66-5 2012 IP Consortium Harlan Magnesium bis(dihydrogenorthophosphate) Magnesium bis(dihydrogenorthophosphate) 31 13092-66-5 8.1 Skin irritation Warren N 2012 OECD 439 - In vitro skin irritancy RHE tissues IP Consortium Harlan 41205083 Magnesium bis(dihydrogenorthophosphate) 31 13092-66-5 8.2 Eye Irritation Warren N 2012 OECD 437 - BCOP bovine eyes IP Consortium Harlan 41205084 Trimanganese bis(orthophosphate) 33 14154-09-7 7.2 Melting/freezing point Walker J 2009 A6 Melting/Freezing Temperature N/A IP Consortium Harlan 2920/0023 Trimanganese bis(orthophosphate) 33 14154-09-7 7.7 Water solubility Walker J 2009 A6 Water Solubility N/A IP Consortium Harlan 2920/0023 Trimanganese bis(orthophosphate) 33 14154-09-7 8.5.1 Acute oral toxicity Bradshaw J 2013 OECD 420 - Acute oral toxicity RAT IP Consortium Harlan 41205118 Trimanganese bis(orthophosphate) 33 14154-09-7 8.1 Skin corrosion Warren N 2013 OECD 431 - In vitro skin corrosion tissues IP Consortium Harlan 41205119 Trimanganese bis(orthophosphate) 33 14154-09-7 8.1 Skin irritation Warren N 2013 OECD 439 - In vitro skin irritancy RHE tissues IP Consortium Harlan 41205120 Trimanganese bis(orthophosphate) 33 14154-09-7 8.2 Eye Irritation Warren N 2013 OECD 437 - BCOP bovine eyes IP Consortium Harlan 41205121 8.2 Eye Irritation Bradshaw J OECD 405 - Acute eye irritation rabbit 41205122 33 14154-09-7 2012 IP Consortium Harlan Trimanganese bis(orthophosphate) Trimanganese bis(orthophosphate) 33 14154-09-7 8.5.2 Acute inhalation toxicity Veiga S 2015 OECD 436 - Acute inhalation rat Budenheim Vivotechnia B-01993 Trimanganese bis(orthophosphate) 33 14154-09-7 8.3 Skin sensitisation Gummer B 2014 OECD Guideline 406 - Guinea Pig guinea pig Budenheim Bioserv 62299-20-147-2014040996 Trimanganese bis(orthophosphate) 33 14154-09-7 8.4.1 In vitro gene mutation study in bacteria Kolp N 2015 OECD 471 - AMES n/a Budenheim Bioserv 62299-20-132-2014040996 Trimanganese bis(orthophosphate) 33 14154-09-7 8.4.2 In vitro micronucleus Prietzsch H 2015 OECD 487 - In vitro mouse CHL fibroblasts V- Budenheim Bioserv 62299-20-164-2014040996 8.4.3 In vitro gene mutation study in mammalian Kolp N OECD 476 - Mouse Lymphoma assay mouse 62299-20-153-2014040996 33 14154-09-7 2015 Budenheim Bioserv Trimanganese bis(orthophosphate) cells lymphoma 9.1.2 Toxicity to aquatic alage Wenzel A OECD 201 - Algal growth inhibition algae BUD-009/4-10/A Trimanganese bis(orthophosphate) 33 14154-09-7 2011 Budenheim Fraunhofer IME 9.1.1 Short-term toxicity to aquatic invertebrates Ziese C & Simon M OECD 202 - Acute immobilisation of daphnia BUD-009/4-20/G Trimanganese bis(orthophosphate) 33 14154-09-7 2015 daphnia (static) Budenheim Fraunhofer IME

Trimanganese bis(orthophosphate) 33 14154-09-7 9.1.3 Short-term toxicity to fish Simon M 2015 OECD 203 - Acute toxicity to fish fish Budenheim Fraunhofer IME BUD-009/4-32/A Trimanganese bis(orthophosphate) 33 14154-09-7 7.4 Relative Density Wagner V 2015 OECD 109 - Relative density N/A Budenheim Ibacon GmbH Project 108181182 Trimanganese bis(orthophosphate) 33 14154-09-7 7.10 Flammability Wagner V 2015 A.10 Determination of flammability N/A Budenheim Ibacon GmbH Project 108181187 7.12 Auto-flammability Wagner V A.16 Determination of the relative N/A Project 108181188 Trimanganese bis(orthophosphate) 33 14154-09-7 2015 Budenheim Ibacon GmbH self-ignition temperature Trimanganese bis(orthophosphate) 33 14154-09-7 7.14 Particle size distribution Ahrens A 2016 OECD 110 - Particle size distribution N/A Budenheim Ibacon GmbH [not known] Trimanganese bis(orthophosphate) 33 14154-09-7 8.4.2 In vitro micronucleus Spruth B 2016 OECD 487 - In vitro mouse human Budenheim LPT 32875 Trimanganese bis(orthophosphate) 33 14154-09-7 8.4.3 In vitro gene mutation study in mammalian Spruth B 2016 OECD 476 - Mouse Lymphoma assay mouse Budenheim LPT 32876 Manganese bis(dihydrogen phosphate) 34 18718-07-5 7.2 Melting/freezing point Butler RE 2009 A6 Melting/Freezing Temperature N/A IP Consortium Harlan 2920/0024 Manganese bis(dihydrogen phosphate) 34 18718-07-5 7.7 Water solubility Butler RE 2009 A6 Water Solubility N/A IP Consortium Harlan 2920/0024 8.5.1 Acute oral toxicity Bradshaw J OECD 420 - Acute oral toxicity Rat 41200864 34 18718-07-5 2012 IP Consortium Harlan manganese bis(dihydrogen phosphate) 8.1 Skin corrosion Warren N OECD 431 - In vitro skin corrosion in vitro tissues 41200865 34 18718-07-5 2012 IP Consortium Harlan manganese bis(dihydrogen phosphate) manganese bis(dihydrogen phosphate) 34 18718-07-5 8.1 Skin irritation Warren N 2012 OECD 439 - In vitro skin irritancy RHE tissues IP Consortium Harlan 41200866 8.2 Eye Irritation Warren N OECD 437 - BCOP bovine eyes 41200867 34 18718-07-5 2012 IP Consortium Harlan manganese bis(dihydrogen phosphate) 8.2 Eye Irritation Bradshaw J OECD 405 - Acute eye irritation Rabbit 41200868 34 18718-07-5 2012 IP Consortium Harlan manganese bis(dihydrogen phosphate) 7.4 Relative Density Budenheim OECD 109 - Relative density n/a OECD109 N/A 34 18718-07-5 2013 Budenheim manganese bis(dihydrogen phosphate) Monomanganphospha

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 13/01/2016 18 Sour

Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year 7.2 Melting/freezing point Butler RE A6 Melting/Freezing Temperature N/A 2920/0025 35 51349-94-1 2009 IP Consortium Harlan Dimanganese phosphate-2-hydrate 7.7 Water solubility Butler RE A6 Water Solubility N/A 2920/0025 35 51349-94-1 2009 IP Consortium Harlan Dimanganese phosphate-2-hydrate 8.5.1 Acute oral toxicity Bradshaw J OECD 420 - Acute oral toxicity Rat 41200869 35 51349-94-1 2012 IP Consortium Harlan manganese hydrogen phosphate manganese hydrogen phosphate 35 51349-94-1 8.1 Skin corrosion Warren N 2012 OECD 431 - In vitro skin corrosion in vitro tissues IP Consortium Harlan 41200870 manganese hydrogen phosphate 35 51349-94-1 8.1 Skin irritation Warren N 2012 OECD 439 - In vitro skin irritancy RHE tissues IP Consortium Harlan 41200871 manganese hydrogen phosphate 35 51349-94-1 8.2 Eye Irritation Warren N 2012 OECD 437 - BCOP bovine eyes IP Consortium Harlan 41200872 8.2 Eye Irritation Bradshaw J OECD 405 - Acute eye irritation Rabbit 41200873 35 51349-94-1 2012 IP Consortium Harlan manganese hydrogen phosphate manganese hydrogen phosphate 35 51349--94-1 7.4 Relative Density [not provided by 2012 Relative density n/a Chemetell AQURA Chemetell Magnesium bis(dihydrogenorthophosphate) 35 13092-66-9 8.2 Eye Irritation Bradshaw J 2012 OECD 405 - Acute eye irritation rabbit IP Consortium Harlan 41205085 8.4.1 In vitro gene mutation study in bacteria Thompson PW OECD 471 - AMES bacteria 41205089 35 51349-94-1 2012 IP Consortium Harlan manganese hydrogen phosphate manganese hydrogen phosphate 35 51349-94-1 8.4.2 In vitro cytogenicity study in mammalian cells Morris A 2012 OECD 473 - Chrom Ab N/A IP Consortium Harlan 41205088 manganese hydrogen phosphate 35 51349-94-1 8.4.3 In vitro gene mutation study in mammalian Brown RW 2012 OECD 476 - Mouse Lymphoma Assay N/A IP Consortium Harlan 41205090 9.1.2 Growth inhibition study in aquatic plants Vryenhoef H OECD 201 - Algal growth inhibition algae 41205086 35 51349-94-1 2012 IP Consortium Harlan manganese hydrogen phosphate Magnesium bis(dihydrogenorthophosphate) 35 13092-66-9 8.2 Eye Irritation Lowe C 2012 OECD 405 / OPPTS 870 2400 - EYE Rabbit Rotem35322PEI Product Safety Labs 35322 9.1.4 Activated sludge respiration inhibition Roulstone P OECD 209 - ASRI sludge mirco- 41205087 35 51349-94-1 2013 IP Consortium Harlan manganese hydrogen phosphate testing organisms 7.2 Melting/freezing point Walker J A6 Melting/Freezing Temperature N/A 2920/0026 36 7798-23-4 2009 IP Consortium Harlan Tricopper bis(orthophosphate) 7.7 Water solubility Walker J A6 Water Solubility N/A 2920/0078 36 7798-23-4 2009 IP Consortium Harlan Tricopper bis(orthophosphate) 8.5.1 Acute oral toxicity Bradshaw J OECD 420 - Acute oral toxicity RAT 41205123 36 7798-23-4 2013 IP Consortium Harlan Tricopper bis(orthophosphate) 8.1 Skin corrosion Warren N OECD 431 - In vitro skin corrosion tissues 41205124 36 7798-23-4 2013 IP Consortium Harlan Tricopper bis(orthophosphate) 8.1 Skin irritation Warren N OECD 439 - In vitro skin irritancy RHE tissues 41205125 36 7798-23-4 2013 IP Consortium Harlan Tricopper bis(orthophosphate) (B.46) 8.2 Eye Irritation Warren N OECD 437 - BCOP bovine eyes 41205126 36 7798-23-4 2013 IP Consortium Harlan Tricopper bis(orthophosphate) 8.4.1 In vitro gene mutation study in bacteria [not known] OECD 471 - AMES s. typhimurium [not known] 36 7798-23-4 2016 Budenheim LPT Tricopper bis(orthophosphate) Tricopper bis(orthophosphate) 36 7798-23-4 8.4.2 In vitro micronucleus [not known] 2016 OECD 487 - In vitro mouse Human Budenheim LPT [not known] Tricopper bis(orthophosphate) 36 7798-23-4 8.4.3 In vitro gene mutation study in mammalian [not known] 2015 OECD 476 - Mouse Lymphoma assay mouse Budenheim LPT [not known] Tricopper bis(orthophosphate) 36 7798-23-4 7.4 Relative Density Wagner V 2016 OECD 109 - Relative density N/A Budenheim Ibacon GmbH [not known] Tricopper bis(orthophosphate) 36 7798-23-4 7.10 Flammability Wagner V 2015 A.10 Determination of flammability N/A Budenheim Ibacon GmbH [not known] 7.12 Auto-flammability Wagner V A.16 Determination of the relative N/A [not known] 36 7798-23-4 2015 Budenheim Ibacon GmbH Tricopper bis(orthophosphate) self-ignition temperature Tricopper bis(orthophosphate) 36 7798-23-4 7.14 Particle size distribution Ahrens A 2016 OECD 110 - Particle size distribution N/A Budenheim Ibacon GmbH [not known] Tricopper bis(orthophosphate) 36 7798-23-4 7.1 Physical state, colour and odour Wagner V 2016 EPA Guidelines N/A Budenheim Ibacon GmbH [not known] Tricopper bis(orthophosphate) 36 7798-23-4 7.2 Melting point Wagner V 2016 OECD 102 - Melting Point N/A Budenheim Ibacon GmbH [not known] Tricopper bis(orthophosphate) 36 7798-23-4 7.7 Water solubility Klawonn Th 2016 OECD 105 - Water solubility N/A Budenheim Fraunhofer IME [not known] 9.1.1 Short term toxicity testing on invertebrates Bernd Aldorf, BTA Acute toxicity Daphnia Daphnia 04111002W201 37 10102-90-6 2004 B31a LAUS copper (II)-pyrophosphate copper (II)-pyrophosphate 37 10102-90-6 8.5.1 Acute oral toxicity Mr D. Kuhn, Dr 2004 Acute oral toxicity Rat Rat B31b Phycher (Laus) TAO423-PH-04/0330 copper (II)-pyrophosphate 37 10102-90-6 7.2 Melting/freezing point Walker J 2009 A6 Melting/Freezing Temperature N/A IP Consortium Harlan 2920/0051 7.7 Water solubility Walker J A6 Water Solubility N/A 2920/0051 37 10102-90-6 2009 IP Consortium Harlan copper (II)-pyrophosphate

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 13/01/2016 19 Sour

Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year copper (II)-pyrophosphate 37 10102-90-6 8.1 Skin irritation Warren N 2013 OECD 439 - In vitro skin irritancy RHE tissues IP Consortium Harlan 41205128 copper (II)-pyrophosphate 37 10102-90-6 8.2 Eye Irritation Warren N 2013 OECD 437 - BCOP bovine eyes IP Consortium Harlan 41205129 8.2 Eye Irritation Bradshaw J OECD 405 - Acute eye irritation rabbit 41205130 37 10102-90-6 2012 IP Consortium Harlan copper (II)-pyrophosphate copper (II)-pyrophosphate 37 10102-90-6 8.3 Skin sensitisation Grummer B 2013 OECD 406 - M&K guinea pig Bioserv1942_001 Bioserv 2012121016 8.5.2 Acute inhalation toxicity Griffiths D OECD 436 - Acute inhalation rat 41206699 37 10102-90-6 2013 IP Consortium Harlan copper (II)-pyrophosphate copper (II)-pyrophosphate 37 10102-90-6 7.14 Granulometry Griffiths D 2013 OECD 110 - Particle Size Distribution n/a IP Consortium Harlan 41206697 7.14 Granulometry Budenheim PSD - in house data n/a N/A 37 10102-90-6 2013 M14-30 Budenheim copper (II)-pyrophosphate copper (II)-pyrophosphate 37 10102-90-6 7.4 Relative Density Budenheim 2013 OECD 109 - Relative density n/a OECD 109 CuPP Budenheim N/A 8.3 Skin sensitisation Grummer B OECD 406 - M&K guinea pig 59272-20-147-2013080131 37 10102-90-6 2014 Budenheim BIOSERV copper (II)-pyrophosphate copper (II)-pyrophosphate 37 10102-90-6 8.5.1 Acute oral toxicity Entzian K 2013 OECD 423 - Acute oral toxicity (Class rat Budenheim Bioserv 59272-11-165-201308131 copper (II)-pyrophosphate 37 10102-90-6 8.1 Skin corrosion Prietzsch H 2014 Acute Dermal Irritation/Corrosion rabbit Budenheim Bioserv 62850-20-128-2014060433 8.3 Skin sensitisation Grummer B OECD Guideline 406 - Guinea Pig guinea pig 59272-20-147-2013080131 37 10102-90-6 2014 Budenheim Bioserv copper (II)-pyrophosphate Maximization Test (GPMT) copper (II)-pyrophosphate 37 10102-90-6 Transformation/dissolution Klawonn Th 2014 OECD 29 - Determination of the N/A Budenheim Fraunhofer IME BUD-003/5-51 copper (II)-pyrophosphate 37 10102-90-6 7.12 Auto-flammability Wagner V 2015 A.16 Determination of the relative N/A Budenheim Ibacon GmbH Project 108171188 copper (II)-pyrophosphate 37 10102-90-6 7.10 Flammability Wagner V 2015 A.10 Determination of flammability N/A Budenheim Ibacon GmbH Project 108171187 copper-II-hydroxyphosphate 38 12158-74-6 9.1.1 Short term toxicity testing on invertebrates Bernd Aldorf, BTA 2004 Acute toxicity Daphnia Daphnia B101a LAUS 04111001W201 8.5.1 Acute oral toxicity Mr D. Kuhn, Dr Acute oral toxicity Rat Rat TAO423-PH-04/0329 38 12158-74-6 2004 B101b Phycher (Laus) copper-II-hydroxyphosphate Francois Richeux Dicopper hydroxide phosphate 38 12158-74-6 7.2 Melting/freezing point Walker J 2009 A6 Melting/Freezing Temperature N/A IP Consortium Harlan 2920/0027 7.7 Water solubility Walker J A6 Water Solubility N/A 2920/0027 38 12158-74-6 2009 IP Consortium Harlan Dicopper hydroxide phosphate 8.5.1 Acute oral toxicity Entzian K OECD 423 - Acute oral toxicity (Class rat 2010081229 38 12158-74-6 2011 Budenheim Bioserv GMBH Dicopper hydroxide phosphate method) 8.4.3 In vitro gene mutation study in mammalian Entzian K OECD 476 - Mouse Lymphoma Assay mouse 2010081229 38 12158-74-6 2011 Budenheim Bioserv GMBH Dicopper hydroxide phosphate cells 8.4.1 In vitro gene mutation study in bacteria Entzian K OECD 471 - AMES bacteria 2010081229 38 12158-74-6 2011 Budenheim Bioserv GMBH Dicopper hydroxide phosphate Dicopper hydroxide phosphate 38 12158-74-6 8.1 Skin irritation Entzian K 2011 Budeheim Bioserv dicopper rabbit Budenheim Bioserv GMBH 2010081229 8.4.3 In vitro gene mutation study in mammalian Prietzsch H OECD 487 - In vitro mouse n/a 2011040713 38 12158-74-6 2012 Budenheim Bioserv GMBH Dicopper hydroxide phosphate cells micronucleus 8.2 Eye Irritation Entzian K Budeheim Bioserv dicopper rabbit 2010081229 38 12158-74-6 2011 Budenheim Bioserv GMBH Dicopper hydroxide phosphate phosphate IP38 tests report 2010: 8.5.2 Acute inhalation toxicity Griffiths D OECD 436 - Acute inhalation Rat 41200874 38 12158-74-6 2012 IP Consortium Harlan Dicopper hydroxide phosphate 8.5.3 Acute dermal toxicity Grummer B OECD 402 - Acute dermal guinea pig 2011040713 38 12158-74-6 2011 Bioserv_OECD 402 Bioserv Dicopper hydroxide phosphate 8.3 Skin sensitisation Grummer B OECD 406 - M&K guinea pig 2011040713 38 12158-74-6 2011 Bioserv_OECD 406 Bioserv Dicopper hydroxide phosphate 8.4.3 In vitro gene mutation study in mammalian Prietzsch H OECD 487 - In vitro mouse mouse 2011040713 38 12158-74-6 2012 Bioserv_OECD 487 Bioserv Dicopper hydroxide phosphate cells micronucleus micronucleus 8.3 Skin sensitisation Grummer B OECD 406 - M&K guinea pig 59272-20-147-2013080132 38 12158-74-6 2014 Budenheim BIOSERV dicopper hydroxide phosphate 9.1.3 Short-term toxicity testing on fish Handlos F & Erk T OECD 203- Acute fish toxicity (SEMI fish 87202230 38 12158-74-6 2014 Budenheim IBACON dicopper hydroxide phosphate STATIC) 9.1.2 Growth inhibition study in aquatic plants Handlos F & Erk T OECD 201 - Algal growth inhibition algae 87201210 38 12158-74-6 2014 Budenheim IBACON dicopper hydroxide phosphate Transformation/dissolution Klawonn Th OECD 29 - Determination of the n/a BUD-002/5-51 38 12158-74-6 2014 Budenheim Fraunhofer IME Copper hydroxide phosphate transformation/dissolution (TdP 8.1 Skin irritation Bullock CH and In vivo skin irritation - rabbits rabbit T-4054 39 13530-50-2 1972 PS-2865 Stauffer Western RC monoaluminium phosphate Kamienski FX.

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 13/01/2016 20 Sour

Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year 8.5.1 Acute oral toxicity Bullock CH and Toxicology lab report rat T-4054 39 13530-50-2 1972 PS-2865 Stauffer Western RC monoaluminium phosphate Kamienski FX. 8.5.1 Acute oral toxicity Joiner RL Toxicology lab report rat T-5510 39 13530-50-2 1975 PS-2915 Stauffer Western RC monoaluminium phosphate 8.1 Skin irritation Joiner RL In vivo skin irritation - rabbits rabbit T-5510 39 13530-50-2 1975 PS-2915 Stauffer Western RC monoaluminium phosphate 8.5.1 Acute oral toxicity Terrell Y and Parke G Acute oral toxicity in rats. rat M0021-75 39 13530-50-2 1975 PS-3708 / M21-75 Cannon (for Mobil) monaluminium phosphate Compound: MCTR-2-75 8.1 Skin irritation Kamienski FX In vivo skin irritation - rabbits rabbit T-1680 39 13530-50-2 1971 PS-2839 Stauffer Western RC monoaluminium phosphate (50% solution) 8.2 Eye Irritation Kamienski FX Toxicology lab report rabbit T-1680 39 13530-50-2 1971 PS-2839 Stauffer Western RC monoaluminium phosphate (50% solution) 8.5.1 Acute oral toxicity Kamienski FX Toxicology lab report rat T-1680 39 13530-50-2 1971 PS-2839 Stauffer Western RC monoaluminium phosphate (50% solution) 8.5.3 Acute dermal toxicity Kamienski FX Toxicology lab report rat T-1680 39 13530-50-2 1971 PS-2839 Stauffer Western RC monoaluminium phosphate (50% solution) 8.2 Eye Irritation Parke G the effects of MCTR-2-75 on the eye rabbit M22-75 39 13530-50-2 1975 mucosa of New Zealand albino rabbit M22-75 Cannon (for Mobil) monaluminium phosphate 8.1 Skin irritation Becker J and Parke G A primary dermal irritation study of rabbit M23-75 39 13530-50-2 1975 MCTR-2-75 on abraded and M23-75 Cannon (for Mobil) monaluminium phosphate nonabraded skin of New Zealand monaluminium phosphate 39 13530-50-2 8.2 Eye Irritation Parke G 1975 the effects of MCTR-20-75 on the rabbit M201-75 Cannon (for Mobil) M201-75 8.1 Skin irritation Parke G A primary dermal irritation study of rabbit M202-75 39 13530-50-2 1975 M202-75 Cannon (for Mobil) monaluminium phosphate MCTR-20-75 on abraded and 8.5.1 Acute oral toxicity Kazimerierz Kita ? rat Zaklady Chemiczne OS-36/01? 39 13530-50-2 2001 monoaluminum phosphate Alwenia monoaluminum phosphate 39 13530-50-2 8.5.3 Acute dermal toxicity Kazimerierz Kita 2001 ? rabbit Zaklady Chemiczne OS-36/01? 8.1 Skin irritation Kazimerierz Kita ? rabbit OS-36/01? Zaklady Chemiczne 39 13530-50-2 2001 Alwenia monoaluminum phosphate 7.2 Melting/freezing point O'Connor B A6 Melting/Freezing Temperature N/A 2920/0029 39 13530-50-2 2009 IP Consortium Harlan Aluminium tris dihydrogenphosphate 7.7 Water solubility O'Connor B A6 Water Solubility N/A 2920/0029 39 13530-50-2 2009 IP Consortium Harlan Aluminium tris dihydrogenphosphate Aluminium tris dihydrogenphosphate 39 13530-50-2 7.4 Relative Density Woolley A 2010 OECD 109 - Relative density N/A IP Consortium Harlan 2920/0103 Aluminium tris dihydrogenphosphate 39 13530-50-2 8.5.2 Acute inhalation toxicity Schuler D 2010 OECD 436 - Acute inhalation rat IP Consortium Harlan C89971 Aluminium tris dihydrogenphosphate 39 13530-50-2 Transformation/dissolution Klawonn Th 2015 OECD 29 - Determination of the n/a Budenheim Fraunhofer IME BUD-006/5-51 Aluminium orthophosphate 40 7784-30-7 7.2 Melting/freezing point O'Connor B 2009 A6 Melting/Freezing Temperature N/A IP Consortium Harlan 2920/0030 7.7 Water solubility O'Connor B A6 Water Solubility N/A 2920/0030 40 7784-30-7 2009 IP Consortium Harlan Aluminium orthophosphate 8.2 Eye Irritation Warren N Reconstructed Human Corneal Model in vitro tissues 2920/0033 40 7784-30-7 2009 IP Consortium Harlan Aluminium orthophosphate Aluminium orthophosphate 40 7784-30-7 8.2 Eye Irritation Bradshaw J 2009 OECD 405 - Acute eye irritation rabbit IP Consortium Harlan 2920/0135 8.1 Skin irritation Warren N OECD 439 - In vitro skin irritancy in vitro tissues 2920/0032 40 7784-30-7 2009 (B.46) IP Consortium Harlan Aluminium orthophosphate 8.4.1 In vitro gene mutation study in bacteria Thompson PW OECD 471 - AMES salmonella 2920/0083 40 7784-30-7 2009 IP Consortium Harlan Aluminium orthophosphate typhimurium, 8.4.2 In vitro cytogenicity study in mammalian cells Bowles A OECD 473 - Chrom Ab human 2920/0084 40 7784-30-7 2009 IP Consortium Harlan Aluminium orthophosphate lymphocytes 8.4.3 In vitro gene mutation study in mammalian Flanders L OECD 476 - Mouse Lymphoma Assay Mouse cell line 2920/0085 40 7784-30-7 2009 IP Consortium Harlan Aluminium orthophosphate cells 8.1 Skin corrosion Warren N OECD 431 - In vitro skin corrosion in vitro tissues 2920/0069 40 7784-30-7 2009 IP Consortium Harlan Aluminium orthophosphate

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 13/01/2016 21 Sour

Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year 8.5.1 Acute oral toxicity Bradshaw J OECD 420 - Acute oral toxicity Rat 2920/0031 40 7784-30-7 2009 IP Consortium Harlan Aluminium orthophosphate 9.1.4 Activated sludge respiration inhibition Clarke N OECD 209 - ASRI soil 2920/0115 40 7784-30-7 2010 IP Consortium Harlan Aluminium orthophosphate testing microorganisms 8.1 Skin irritation Giannini P skin irritation in vivo Rabbit B79121 40 7784-30-7 2008 BASF RCC Ltd Aluminium orthophosphate 8.3 Skin sensitisation Bradshaw J OECD 429 - LLNA mouse 41200876 40 7784-30-7 2012 IP Consortium Harlan aluminium dihydrogen triphosphate 7.2 Melting/freezing point O'Connor B A6 Melting/Freezing Temperature N/A 2920/0059 41 13939-25-8 2009 IP Consortium Harlan aluminium dihydrogen triphosphate aluminium dihydrogen triphosphate 41 13939-25-8 7.7 Water solubility O'Connor B 2009 A6 Water Solubility N/A IP Consortium Harlan 2920/0059 8.5.1 Acute oral toxicity Bradshaw J OECD 420 - Acute oral toxicity Rat 41200882 41 13939-25-8 2012 IP Consortium Harlan aluminium dihydrogen triphosphate aluminium dihydrogen triphosphate 41 13939-25-8 8.1 Skin corrosion Warren N 2012 OECD 431 - In vitro skin corrosion Tissues IP Consortium Harlan 41200883 aluminium dihydrogen triphosphate 41 13939-25-8 8.1 Skin irritation Warren N 2012 OECD 439 - In vitro skin irritancy RHE tissues IP Consortium Harlan 41200884 aluminium dihydrogen triphosphate 41 13939-25-8 8.2 Eye Irritation Warren N 2012 OECD 437 - BCOP bovine eyes IP Consortium Harlan 41200885 aluminium dihydrogen triphosphate 41 13939-25-8 8.2 Eye Irritation Bradshaw J 2012 OECD 405 - Acute eye irritation rabbit IP Consortium Harlan 41200886 aluminium dihydrogen triphosphate 41 13939-25-8 8.5.2 Acute inhalation toxicity Griffiths D 2012 OECD 436 - Acute inhalation Rat IP Consortium Harlan 41200887 9.1.1 Short term toxicity testing on invertebrates Ecological Science Reproductive toxicity of Daphnia daphnia AlTPP_A010480- Mitsubishi Chemical A010480-3 41 13939-25-8 2004 aluminium dihydrogen triphosphate Laboratory magna 3_DaphniaRepro Safety Institute Ltd. aluminium dihydrogen triphosphate 41 13939-25-8 9.1.2 Growth inhibition study in aquatic plants Ecological Science 2003 OECD 201: Growth inhibition study in algae AlTPP_A010480- Mitsubishi Chemical A010480-1 aluminium dihydrogen triphosphate 41 13939-25-8 9.1.1 Short term toxicity testing on invertebrates Ecological Science 2004 OECD 202 - Acute toxicity in daphnia daphnia AlTPP_A010480- Mitsubishi Chemical A010480-2 9.1.3 Short-term toxicity testing on fish Ecological Science OECD 203: Acute toxicity to fish FISH AlTPP_A010480- Mitsubishi Chemical A010480-4 41 13939-25-8 2003 aluminium dihydrogen triphosphate Laboratory 2_AcuteFish Safety Institute Ltd. 9.3.2 Bioaccumulation in aquatic species, Chemicals Evaluation Bioaccumulation in fish Fish AlTPP_43678_Bioaccu Chemicals Evaluation and 43678 41 13939-25-8 2001 aluminium dihydrogen triphosphate preferably fish and Research Institute m Research Institute aluminium dihydrogen triphosphate 41 13939-25-8 8.6.1 / 8.7.1 Repeated dose toxicity (28 days) / Safety Research 2002 OECD 422 - screening study rats Lingvo Safety Research Institute SR00109 8.4.1 In vitro gene mutation study in bacteria Applied Biological OECD 471 - AMES bacteria IP 41 Ames Test OECD Mitsubishi Chemical B010039 41 13939-25-8 2002 aluminium dihydrogen triphosphate Research Department, 471 Safety Institute Ltd. 8.4.2 In vitro cytogenicity study in mammalian cells Applied Biological OECD 473 - Chromosome Aberration CHL fibroblasts V- IP 41 CA Test OECD Mitsubishi Chemical B010040 41 13939-25-8 2002 aluminium dihydrogen triphosphate Research Department, 79 473 Safety Institute Ltd. aluminium dihydrogen triphosphate 41 13939-25-8 8.4.3 In vitro gene mutation study in mammalian Applied Biological 2007 OECD 474 - In vivo mouse mice IP 41 in vivo MN Test Mitsubishi Chemical M-1254 aluminum metaphosphate 42 13776-88-0 8.1 Skin irritation Joiner RL 1975 In vivo skin irritation - rabbits rabbit PS-2914 Stauffer Western RC T-5509 aluminum metaphosphate 42 13776-88-0 8.5.1 Acute oral toxicity Joiner RL 1975 Toxicology lab report rat PS-2914 Stauffer Western RC T-5509 aluminium metaphosphate 42 13776-88-0 8.5.1 Acute oral toxicity Kamienski FX 1971 Toxicology lab report rat PS-2839 Stauffer Western RC T-1680 8.5.3 Acute dermal toxicity Kamienski FX Toxicology lab report rabbit T-1680 42 13776-88-0 1971 PS-2839 Stauffer Western RC aluminium metaphosphate aluminium metaphosphate 42 13776-88-0 8.1 Skin irritation Kamienski FX 1971 In vivo skin irritation - rabbits rabbit PS-2839 Stauffer Western RC T-1680 aluminium metaphosphate 42 13776-88-0 8.2 Eye Irritation Kamienski FX 1971 Toxicology lab report rabbit PS-2839 Stauffer Western RC T-1680 aluminium metaphosphate 42 13776-88-0 8.5.1 Acute oral toxicity Entzian K 2013 OECD 423 - Acute oral toxicity (Class rat Aluminium Biosev 2013020386 aluminium metaphosphate 42 13776-88-0 7.4 Relative Density Budenheim 2013 OECD 109 - Relative density n/a OECD 109 Budenheim N/A 8.1 Skin irritation Prietzsch H OECD 404- dermal irritation / rat 2013020386 42 13776-88-0 2014 Budenheim BIOSERV aluminium metaphosphate corrosion aluminium metaphosphate 42 13766-88-0 7.2 Melting/freezing point Fox J 2013 A6 Melting/Freezing Temperature N/A IP Consortium Harlan 41300379 aluminium metaphosphate 42 13766-88-0 7.7 Water solubility Fox J 2013 A6 Water Solubility N/A IP Consortium Harlan 41300379 aluminium metaphosphate, type B 42 13766-88-0 7.7 Water solubility Fox J 2013 A6 Water Solubility N/A IP Consortium Harlan 41300534 aluminium metaphosphate 42 13776-88-0 8.5.2 Acute inhalation toxicity Veiga S 2015 OECD 436 - Acute inhalation rat Budenheim Vivotechnia B-01991 aluminium metaphosphate 42 13776-88-0 8.3 Skin sensitisation Grummer B 2014 OECD 406 - M&K guinea pig Budenheim Bioserv 61878-20-147-2014030822 8.4.1 In vitro gene mutation study in bacteria Kolp N OECD 471 - AMES bacteria 61878-20-132-2014030822 42 13776-88-0 2014 Budenheim Bioserv aluminium metaphosphate aluminium metaphosphate 42 13776-88-0 8.4.2 In vitro micronucleus Prietzsch H 2015 OECD 487 - In vitro mouse cells Budenheim Bioserv 61878-20-164-2014030822 aluminium metaphosphate 42 13776-88-0 8.4.3 In vitro gene mutation study in mammalian Kolp N 2015 OECD 476 - Mouse Lymphoma assay cell line L5178Y Budenheim Bioserv 61878-20-153-2014030822 aluminium metaphosphate 42 13776-88-0 8.2 Eye Irritation Prietzch H 2014 OECD 405 - Acute eye irritation rabbit Budenheim Bioserv 57190-20-133-2013020386 9.1.2 Growth inhibition study in aquatic plants Wenzel A OECD 201 - Algal growth inhibition algae BUD-005/4-10/A 42 13776-88-0 2014 Budenheim Frauhofer IME aluminium metaphosphate aluminium metaphosphate 42 13776-88-0 9.1.1 Short term toxicity testing on invertebrates Simon M 2014 OECD 202 - Acute toxicity in daphnia Daphnia magna Budenheim Frauhofer IME BUD-005/4-20/G

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 13/01/2016 22 Sour

Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year aluminium metaphosphate 42 13776-88-0 9.1.3 Short-term toxicity testing on fish Simon M 2015 oecd 203 - Acute toxicity to fish fish Budenheim Frauhofer IME BUD-005/4-32/A aluminium metaphosphate 42 13776-88-0 Transformation/dissolution Klawonn Th 2015 OECD 29 - Determination of the n/a Budenheim Fraunhofer IME BUD-005/5-51 Analytical Methods Klawonn Th Chemical Analytics Aluminium for N/A N/A 42 13776-88-0 2015 Budenheim Fraunhofer IME aluminium metaphosphate aquatic toxicity tests (Method 8.4.2 In vitro micronucleus Spruth B OECD 487 - In vitro micronucleus huamn 32790 42 13776-88-0 2016 Budenheim LPT aluminium metaphosphate peripheral 8.6.2 Subchronic toxicity study Smith P.S. 90 days subacute oral toxicity Rats BTL-71-49 B 43 7785-88-8 1972 BK1 Bio-test sodium aluminum phosphate sodium aluminum phosphate 43 7785-88-8 8.6.2 Subchronic toxicity study Reyna M.S. 1973 90 days subacute oral toxicity Rats BK2 Bio-test BTL-71-49 D sodium aluminum phosphate 43 7785-88-8 8.6.1 Short-term repeated dose toxicity Smith P.S. 1972 30 days pilot study, oral Rats BK3 Bio-test BTL-71-49 A sodium aluminum phosphate 43 7785-88-8 8.6.2 Subchronic toxicity study Mastalski K. 1972 90 days subacute oral toxicity Dogs BK4 Bio-test BTL-71-49 C sodium aluminum phosphate 43 7785-88-8 8.6.2 Subchronic toxicity study Pettersen JC, Zwicker 1987 26-week subchronic toxicity study Dog PS-2804 Stauffer Western RC T-12969 8.5.1 Acute oral toxicity Bullock CH Acute oral toxicity of levn-lite in male Rat T-1627 43 7785-88-8 1970 PS-2821 Stauffer Western RC sodium aluminum phosphate rats sodium aluminum phosphate 43 7785-88-8 8.1 Skin irritation Bullock CH and 1972 In vivo skin irritation - rabbits rabbit PS-2865 Stauffer Western RC T-4054 sodium aluminum phosphate 43 7785-88-8 8.6.2 Subchronic toxicity study Katz AC 1981 A 6-month sub-chronic dietary study dogs PS-2947 Stauffer Western RC T-10195 8.5.1 Acute oral toxicity Jones BJ Toxicology lab report rat T-10236 43 7785-88-8 1980 PS-2948 Stauffer Western RC sodium aluminum phosphate (KASAL) sodium aluminum phosphate (KASAL) 43 7785-88-8 8.5.3 Acute dermal toxicity Jones BJ 1980 Toxicology lab report rabbit PS-2948 Stauffer Western RC T-10236 sodium aluminum phosphate (KASAL) 43 7785-88-8 8.1 Skin irritation Jones BJ 1980 In vivo skin irritation - rabbits rabbit PS-2948 Stauffer Western RC T-10236 sodium aluminum phosphate (KASAL) 43 7785-88-8 8.2 Eye Irritation Jones BJ 1980 Toxicology lab report - in vivo rabbit PS-2948 Stauffer Western RC T-10236 8.6.1 Short-term repeated dose toxicity Sprague GL 4-week dietary comparative toxicity rat T-12644 43 7785-88-8 1986 PS- 2969 Stauffer Western RC sodium aluminum phosphate study with KASAL in rats, oral, 28-day sodium aluminium phosphate 43 7785-88-8 8.2 Eye Irritation n/a n/a PS-2855 Stauffer Western RC T-1775 sodium aluminum phosphate 43 7785-88-8 8.6.2 Subchronic toxicity study Smith PS 1972 90-day subacute oral toxicity study rat PS-2751 Bio Lab (for Stauffer) T-6685 /IBT no. B747 sodium aluminum phosphate 43 7785-88-8 8.6.2 Subchronic toxicity study Smith PS 1972 90-day subacute oral toxicity study rat PS-2807 Bio Lab (for Stauffer) T-6686, IBT B747 sodium aluminum phosphate 43 7785-88-8 8.6.2 Subchronic toxicity study Reyna MS 1973 90-day subacute oral toxicity study rat PS-2808 Bio Lab (for Stauffer) T-6684 sodium aluminum phosphate 43 7785-88-8 8.6.2 Subchronic toxicity study Mastalski K. 1972 90-day subacute oral toxicity study dog PS-2809 Bio Lab (for Stauffer) T-6503 / IBT J749 8.6.2 Subchronic toxicity study Mastalski K. 90-day subacute oral toxicity study dog T-6687 / IBT: J749 43 7785-88-8 1972 PS-2934 Bio Lab (for Stauffer) sodium aluminum phosphate with KASAL in Beagle dogs sodium aluminium phosphate 1:3:8 43 7785-88-8 7.2 Melting/freezing point O'Connor B 2009 A6 Melting/Freezing Temperature N/A IP Consortium Harlan 2920/0034 sodium aluminium phosphate 1:3:8 43 7785-88-8 7.7 Water solubility O'Connor B 2009 A6 Water Solubility N/A IP Consortium Harlan 2920/0034 sodium aluminium phosphate 1:3:8 43 7785-88-8 7.4 Relative Density O'Connor B 2010 OECD 109 - Relative density N/A IP Consortium Harlan 2920/ 7.2 Melting/freezing point O'Connor B A6 Melting/Freezing Temperature N/A 2920/0073 43 7785-88-8 2009 IP Consortium Harlan sodium aluminium phosphate 3:2:8 7.7 Water solubility O'Connor B A6 Water Solubility N/A 2920/0073 43 7785-88-8 2009 IP Consortium Harlan sodium aluminium phosphate 3:2:8 Stabil 9 019 (Sodium aluminium phosphate 65% and 8.2 Eye Irritation Lowe C Eye irritation in vivo Rabbit 31520 43 7785-88-8 2011 ICLPP Eurofins monocalcium phosphate 35%) sodium aluminium phosphate (>90%) 43 7785-88-8 8.2 Eye Irritation Durando J 2011 Eye irritation in vivo Rabbit ICLPP Eurofins 31521 Sodium aluminium phosphate 43 7785-88-8 8.5.1 Acute oral toxicity Bradshaw J 2012 OECD 420 - Acute oral toxicity Rat IP Consortium Harlan 41200879 8.1 Skin irritation Warren N OECD 439 - In vitro skin irritancy RHE tissues 41200880 43 7785-88-8 2012 IP Consortium Harlan Sodium aluminium phosphate (B.46) 8.1 Skin corrosion Warren N OECD 431 - In vitro skin corrosion Tissues 41200881 43 7785-88-8 2012 IP Consortium Harlan Sodium aluminium phosphate Boron orthophosphate 44 13308-51-5 7.2 Melting/freezing point O'Connor B 2009 A6 Melting/Freezing Temperature N/A IP Consortium Harlan 2920/0028 Boron orthophosphate 44 13308-51-5 7.7 Water solubility O'Connor B 2009 A6 Water Solubility N/A IP Consortium Harlan 2920/0028 7.7 Water solubility O' Connor B OECD 105 Solubility in simulated n/a 41203846 44 13308-51-5 2012 IP Consortium Harlan Boron orthophosphate gastric fluid (bioavailability) Boron orthophosphate 44 13308-51-5 8.5.1 Acute oral toxicity Bradshaw J 2012 OECD 420 - Acute oral toxicity rat IP Consortium Harlan 41204125 8.5.2 Acute inhalation toxicity Griffiths D OECD 436 - Acute inhalation rat 41204126 44 13308-51-5 2012 IP Consortium Harlan Boron orthophosphate Boron orthophosphate 44 13308-51-5 8.1 Skin corrosion Warren N 2012 OECD 431 - In vitro skin corrosion tissues IP Consortium Harlan 41204127 8.1 Skin irritation Warren N OECD 439 - In vitro skin irritancy RHE tissues 41204128 44 13308-51-5 2012 IP Consortium Harlan Boron orthophosphate (B.46) Boron orthophosphate 44 13308-51-5 8.2 Eye Irritation Warren N 2012 OECD 437 - BCOP bovine eyes IP Consortium Harlan 41204129

Studies owned by the Consortium, by companies, or by other parties IP Studies list - PART ** I ** Inorganic Phosphates (IP) Consortium - Company owned studies 13/01/2016 23 Sour

Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year 8.2 Eye Irritation Bradshaw J OECD 405 - Acute eye irritation rabbit 41204130 44 13308-51-5 2012 IP Consortium Harlan Boron orthophosphate Boron orthophosphate 44 13308-51-5 8.3 Skin sensitisation Bradshaw J 2012 OECD 429 - LLNA mouse IP Consortium Harlan 41204131 boron orthophosphate 44 13308-51-5 7.7 Water solubility O'Connor B 2013 Water Solubility (total boron by ICP- N/A IP Consortium Harlan 41301749 boron orthophosphate 44 13308-51-5 8.6.2 Subchronic toxicity study [not provided by 2015 OECD 408 - sub-chronic toxicity Mouse Budenheim Bioserv ONGOING boron orthophosphate 44 13308-51-5 8.4.1 In vitro gene mutation study in bacteria Kolp N 2015 OECD 471 - AMES bacteria Budenheim Bioserv 62236-20-132-2014040790 8.4.3 In vitro gene mutation study in mammalian Kolp N OECD 476 - Mouse Lymphoma assay mouse 62236-20-153-2014040790 44 13308-51-5 2014 Budenheim Bioserv boron orthophosphate cells lymphoma cell boron orthophosphate 44 13308-51-5 8.4.2. In vitro micronucleus Prietzsch H 2015 OECD 487 - In vitro mouse CHL fibroblasts V- Budenheim Bioserv 62236-20-164-201040790 boron orthophosphate 44 13308-51-5 9.1.2 Growth inhibition study in aquatic plants Wenzel A 2014 OECD 201 - Algal growth inhibition algae Budenheim Frauhofer IME BUD-004/4-10/A boron orthophosphate 44 13308-51-5 9.1.1 Short term toxicity testing on invertebrates Simon M 2014 OECD 202 - Acute toxicity in daphnia Daphnia magna Budenheim Frauhofer IME BUD-004/4-20/G boron orthophosphate 44 13308-51-5 9.1.3 Short-term toxicity testing on fish Simon M 2015 OECD 203 - Acute toxicity to fish fish Budenheim Frauhofer IME BUD-004/4-32/A 8.2 Eye Irritation Prietzsch H OECD 405 - Acute eye irritation rabbit 62236-20-133-2014040790 44 13308-51-5 2014 Budenheim Bioserv boron orthophosphate boron orthophosphate 44 13308-51-5 8.4.3 In vitro gene mutation study in mammalian Kolp N 2015 OECD 476 - Mouse Lymphoma assay mouse Budenheim Bioserv 62236-20-153-2014040790 9.1.5 Long-term toxicity to aquatic invertebrates Simon M OECD 211 - Daphnia reproduction Daphnia magna BUD-004/4-2/G 44 13308-51-5 2015 Budenheim Fraunhofer IME boron orthophosphate boron orthophosphate 44 13308-51-5 9.4.4 Long-term effects on terrestrial organisms Simon M 2015 OECD 222 - Chronic earthworm Earthworm Budenheim Fraunhofer IME BUD – 004 / 4-80 boron orthophosphate 44 13308-51-5 9.1.4 Toxicity to microorganisms Simon M 2015 OECD 209 - ASRI activated sludge Budenheim Fraunhofer IME BUD-004/4-0 6 boron orthophosphate 44 13308-51-5 Not applicable Klawonn Th 2015 Chemical Analytics Boron for aquatic N/A Budenheim Fraunhofer IME N/A boron phosphate 46 13308-51-5 9.1.1 Short term toxicity testing on invertebrates Dr. H. Lebertz 1999 Acute toxicity Daphnia Daphnia B38 Fresenius 98TE181172 Sodium potassium tripolyphosphate / pentapotassium 46 24315-83-1 7.2 Melting/freezing point O'Connor B 2009 A6 Melting/Freezing Temperature N/A IP Consortium Harlan 2920/0055 7.7 Water solubility O'Connor B A6 Water Solubility N/A 2920/0055 Sodium potassium tripolyphosphate / pentapotassium 46 24315-83-1 2009 IP Consortium Harlan pentasodium bis(triphosphate) Disodium fluorophosphate 47 10163-15-2 7.2 Melting/freezing point Walker J 2009 A6 Melting/Freezing Temperature N/A IP Consortium Harlan 2920/0064 Disodium fluorophosphate 47 10163-15-2 7.7 Water solubility Walker J 2009 A6 Water Solubility N/A IP Consortium Harlan 2920/0064 9.2.2.1 Hydrolysis as a function of pH O'Connor B Hydrolysis as a function of pH N/A 2920/0064 47 10163-15-2 2009 IP Consortium Harlan Disodium fluorophosphate 7.13 Oxidising properties O'Connor B Oxidising properties expert N/A 2920/0064 47 10163-15-2 2009 IP Consortium Harlan Disodium fluorophosphate statement 7.11 Explosive properties O'Connor B Explosivity expert statement N/A 2920/0064 47 10163-15-2 2009 IP Consortium Harlan Disodium fluorophosphate 8.3 Skin sensitisation Bradshaw J OECD 429 - LLNA Mouse 2920/0065 47 10163-15-2 2009 IP Consortium Harlan Disodium fluorophosphate 8.1 Skin corrosion Warren N OECD 431 - In vitro skin corrosion in vitro tissues 2920/0066 47 10163-15-2 2009 IP Consortium Harlan Disodium fluorophosphate 8.1 Skin corrosion Warren N OECD 431 - In vitro skin corrosion in vitro tissues 2920/0072 47 10163-15-2 2009 IP Consortium Harlan Disodium fluorophosphate 8.2 Eye Irritation Warren N Reconstructed Human Corneal Model in vitro tissues 2920/0067 47 10163-15-2 2009 IP Consortium Harlan Disodium fluorophosphate 8.4.1 In vitro gene mutation study in bacteria Thompson PW OECD 471 - AMES salmonella 2920/0086 47 10163-15-2 2009 typhimurium, IP Consortium Harlan Disodium fluorophosphate Escherichia coli 8.4.3 In vitro gene mutation study in mammalian Flanders L OECD 476 - Mouse Lymphoma Assay Mouse cell line 2920/0087 47 10163-15-2 cells 2009 IP Consortium Harlan Disodium fluorophosphate 7.4 Relative Density Woolley OECD 109 - Relative density N/A 2920/0110 47 10163-15-2 2010 IP Consortium Harlan Disodium fluorophosphate

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Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year 9.1.3 Short-term toxicity testing on fish Vryenhof H OECD 203 (semi-static) fish: rainbow 2920/0116 47 10163-15-2 2010 trout IP Consortium Harlan Disodium fluorophosphate 9.1.1 Short term toxicity testing on invertebrates Priestly S OECD 202 - Acute toxicity in daphnia daphnia 2920/0117 47 10163-15-2 2010 IP Consortium Harlan Disodium fluorophosphate 9.1.2 Growth inhibition study in aquatic plants Vryenhof H OECD 201 - Algal growth inhibition algae 2920/0118 47 10163-15-2 2010 IP Consortium Harlan Disodium fluorophosphate 9.1.4 Activated sludge respiration inhibition Clarke N OECD 209 - ASRI soil 2920/0119 testing microorganisms 47 10163-15-2 2010 IP Consortium Harlan Disodium fluorophosphate Disodium fluorophosphate 47 10163-15-2 8.6.1 Short-term repeated dose toxicity and 8.7.1 Dunster J 2010 OECD 422 - range finder rat IP Consortium Harlan 2920/0122 8.6.1 Short-term repeated dose toxicity and 8.7.1 Dunster J OECD 422 -FULL STUDY rat 2920/0123 47 10163-15-2 2010 IP Consortium Harlan Disodium fluorophosphate Screening for reproductive/developmental toxicity 8.2 Eye Irritation Bradshaw J OECD 405 - Acute eye irritation rabbit 2920/0129 47 10163-15-2 2010 IP Consortium Harlan Disodium fluorophosphate Disodium fluorophosphate 47 10163-15-2 8.5.2 Acute inhalation toxicity Schuler D 2010 OECD 436 - Acute inhalation rat IP Consortium Harlan C89982 Phosphoric acid 48 7664-38-2 8.1 Skin irritation Freeman C 1989 In vivo skin irritation - rabbits Rabbits F28 FMC I 88-1050 Phosphoric acid 48 7664-38-2 8.2 Eye Irritation Bullock CH and 1971 Toxicology lab report - in vivo rabbit PS-2845 Stauffer Western RC T-1731 Phosphoric acid 48 7664-38-3 8.1 Skin irritation Bullock CH and 1971 In vivo skin irritation - rabbits rabbit PS-2845 Stauffer Western RC T-1731 8.1 Skin irritation Bullock CH and In vivo skin irritation - rabbits rabbit T-1777 48 7664-38-2 1971 PS-2856 Stauffer Western RC Phosphoric acid Kamienski FX. Phosphoric acid 48 7664-38-2 8.5.1 Acute oral toxicity Terrell Y & Parke E 1975 Acute oral toxicity in rats. rat PS-3700 Cannon (for Mobil) M11-75 Phosphoric acid 48 7664-38-2 8.5.1 Acute oral toxicity ? 1975 Acute oral toxicity in rats. rat PS-3701 Cannon (for Mobil) M12-75 Phosphoric acid 48 7664-38-2 8.5.3 Acute dermal toxicity Becker J and Parke G 1975 the acute dermal toxicity study of rabbit PS-3702 Cannon (for Mobil) M13-75 8.2 Eye Irritation Becker J and Parke G The effects of MCTR-1-75 on the eye rabbit M14-75 48 7664-38-2 1975 PS-3703 Cannon (for Mobil) Phosphoric acid mucosa of new zealand abino rabbits 8.1 Skin irritation Becker J and Parke G A primary dermal irritation study of rabbit M15-75 48 7664-38-2 1975 PS-3704 Cannon (for Mobil) Phosphoric acid MCTR-1-75 on abraded and 8.1 Skin corrosion Lewis CA A dermal corrosion study in albino rabbit Consumer product testing study no: 79230-1 48 7664-38-2 1979 PS-3705 phosphoric acid (75%) rabbits. Compound: MCTR-67-79 (for Mobil) 8.5.1 Acute oral toxicity ? ?? Anorganisches 93/64? 48 7664-38-2 ? 1964_0093 phosphoric acid Laboratorium 8.5.1 Acute oral toxicity Scholz and Weigand Toxikologische Prüfung von rat 111/68 reinigerkomponenten 48 7664-38-2 1967/68 1968_0111 Farbwerke Hoehst AG phosphoric acid 8.1 Skin irritation Scholz and Weigand Toxikologische Prüfung von rabbit 111/68 48 7664-38-2 1967/68 1968_0111 Farbwerke Hoehst AG phosphoric acid reinigerkomponenten - in vivo 8.1 Skin irritation Scholz and Weigand Pastöse Phosphorsäure. VP Kn 500 rabbit 0130/71 48 7664-38-2 1971? 1971/0130 Farbwerke Hoehst AG mixture containing 52.5% phosphoric acid mixture containing 52.5% phosphoric acid 48 7664-38-2 8.2 Eye Irritation Scholz and Weigand 1971? Pastöse Phosphorsäure. VP Kn 500 rabbit 1971/0130 Farbwerke Hoehst AG 0130/71 8.1 Skin irritation Weigand W Phosorige Säure Prüng auf rabbit 85.0015 48 7664-38-2 1985 1985-0015 Hoechst phosphoric acid Hautreizung am Kaninchen 8.5.3 Acute dermal toxicity Imlay P and Parke G Report on the acute dermal toxicity rabbit M1922-77 48 7664-38-2 1977 AW_acute dermal… Cannon (for Mobil) phosphoric acid of rabbits Compound: MCTR-192-77 8.2 Eye Irritation Becker J and Parke G Report on rabbit eye irritation rabbit M511-76 48 7664-38-2 1976 CL_M511-76 Cannon (for Mobil) phosphoric acid Compound: MCTR-51-76 8.4.1 In vitro gene mutation study in bacteria Choi S.A, Hong E.K AMES test bacteria G01-08085 48 7664-38-2 2008 NIER - Korea Medvill Co.Ltd phosphoric acid 8.4.1 In vitro gene mutation study in bacteria Thompson PW OECD 471 - AMES S.TYPHIMURIUM 2920-0142 48 7664-38-2 2010 IP Consortium Harlan phosphoric acid AND E. COLI

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Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year 8.4.3 In vitro gene mutation study in mammalian Brown RW OECD 476 - Mouse Lymphoma Assay Mouse cell line 3045/0001 48 7664-38-2 cells 2010 IP Consortium Harlan phosphoric acid 8.4.1 In vitro gene mutation study in bacteria Choi SA In vitro gene mutation in bacterial bacteria G01-08085 48 7664-38-2 2008 cells NIER Medvill Co.Ltd phosphoric acid 8.4.2 In vitro cytogenicity study in mammalian cells Lacey FE OECD 473 - Chrom Ab N/A 41301393 48 7664-38-2 2013 IP Consortium Harlan phosphoric acid 8.1 Skin corrosion Warren N OECD 431 - In vitro skin corrosion N/A 41304434 48 7664-38-2 2014 IP Consortium Harlan phosphoric acid 5%, 10% and 20% 8.1 Skin corrosion Warren N OECD 431 - In vitro skin corrosion N/A 41304435 48 7664-38-2 2014 IP Consortium Harlan phosphoric acid 5%, 10% and 20% 8.1 Skin corrosion Warren N OECD 431 - In vitro skin corrosion N/A 41304436 48 7664-38-2 2014 IP Consortium Harlan phosphoric acid 5%, 10% and 20% 9.1.1 Short term toxicity testing on invertebrates Priestly SA and Mullee OECD 202 - Acute toxicity in daphnia daphnia 2920/0144 48 7664-38-2 2010 IP Consortium Harlan phosphoric acid DM 9.1.2 Growth inhibition study in aquatic plants Vryenhoef H and OECD 201 - Algal growth inhibition Algae 2920-0145 48 7664-38-2 Mullee DM 2010 (Desmodesmus IP Consortium Harlan phosphoric acid subspicatus) 9.1.2 Growth inhibition study in aquatic plants Yeom D-H OECD 201 - Algal growth inhibition Algae Phosphoric_acid(CAS_ Korean Institute of EG07063 48 7664-38-2 ? phosphoric acid (Pseudokirchneri No.7664-38-2)_Algae Toxicology, KRICT 9.1.1 Short term toxicity testing on invertebrates Yeom D-H OECD 202 - Acute toxicity in daphnia daphnia Phosphoric_acid(CAS_ EG05041 Korean Institute of 48 7664-38-2 ? No.7664-38- Toxicology, KRICT phosphoric acid 2)_Daphnia 9.1.3 Short-term toxicity testing on fish Yeom D-H OECD 203- Acute fish toxicity red killfish, Phosphoric_acid(CAS_ Korean Institute of EG05040 48 7664-38-2 ? phosphoric acid oryzias latipes No.7664-38-2)_Fish Toxicology, KRICT 7.2 Melting/freezing point, 7.3 Boiling point, 7.4 Holzschuh Experimental determination of some Swiss Institute for 48 7664-38-2 Density, 7.5 Vapour pressure 2010 physico-chemical properties of Safety and Security phosphoric acid phosphoric acid 100% EU A.1, EU A.2, 8.1 Skin irritation, 8.2 Eye irritation, 8.5.1 Acute Weigand and Scholz Toxicological Assessment of Cleaning rats, rabbits oral toxicity Agent Components 48 7664-38-2 1968 Farbwerke Hoechst phosphoric acid 8.5.1 Acute oral toxicity Han Z-Z OECD 423 - Acute oral toxicity (Class rats PA_Korean / N/A - Korean study from Preclinical research 48 7664-38-2 2008 method) Phosphoric_acid(CAS_ NIER centre, ChemOn Inc phosphoric acid No.7664-38-2)_acute 8.2 Eye Irritation Wilhoyte HJ Eye irritation rabbits 33-64 48 7664-38-2 1964 PA_HL-33-64 Dupont phosphoric acid (85%) 8.2 Eye Irritation Hood DB Eye irritation rabbits 412-70 48 7664-38-2 1970 PA_HL-412-70 Dupont phosphoric acid (85%) 8.4.2 In vitro cytogenicity study in mammalian cells Kim S-H OECD 473 - In vitro mammalian N/A Phosphoric_acid(CAS_ R05145 48 7664-38-2 2005 Biotoxtech Co. Ltd phosphoric acid chromosome aberration test No.7664-38-2)_In 8.6.1 Short-term repeated dose toxicity and 8.7.1 Hwang J-S Summary only rats B08008 Phosphoric_acid(CAS_ Screening for reproductive/developmental toxicity 48 7664-38-2 2008 No.7664-38- Biotoxtech Co. Ltd study 2)_reproduction phosphoric acid phosphoric acid (30%) 48 7664-38-2 8.1 Skin corrosion McAlack JW 1974 Skin corrosion rabbits Dupont PA_HL-498-74 408-74 phosphoric acid (Acid-Sand slurry - composition unknown) 48 7664-38-2 8.1 Skin irritation Edwards DF 1977 Skin irritation rabbits Dupont PA_HL-523-77 523-77 8.1 Skin irritation and 8.2 Eye irritation Weigand and Scholz Skin and mucous membrance rabbits 48 7664-38-2 1971 tolerance (skin and eye irritation) Farbwerke Hoechst phosphoric acid - unlikely to be pure phosphoric acid

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Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year 8.1 Skin irritation Gelbke & Grundler Primary skin irritation (no guideline) rabbit 79/412 48 7664-38-2 1980 PA_BASF_1980 BASF phosphoric acid (19% + unknown) phosphoric acid (80%) 48 7664-38-2 8.1 Skin irritation Gelbke & Grundler 1980 Primary skin irritation (no guideline) rabbit PA_BASF_1980_2 BASF 79/322 8.1 Skin irritation Henkel skin irritation in vivo - patch test rabbit N/A 48 7664-38-2 1970's PA-HENKEL_1977 Henkel phosphoric acid (100%) 8.1 Skin corrosion Randall DJ & Robinson skin irritation, department of rabbit n/a 48 7664-38-2 1975-77 PA_RANDALL_1976_ Monsanto company phosphoric acid (75% / 80% / 85%) EC transport (DOT) skin corrosion 8.1 Skin irritation Bullock CH and Heil JF In vivo skin irritation - rabbits rabbit T-4176 49 8017-16-1 1973 PS-2868 Stauffer Western RC polyphosphoric acid 8.5.1 Acute oral toxicity Weigand W ? rat 0052/72 49 8017-16-1 1972 1972-0005 ? polyphosphoric acid polyphosphoric acid 49 8017-16-1 8.1 Skin irritation ? 1973 Berict über die Prüfung der haut - rabbit 1973-0202 Farbwerke Hoehst AG 0202/73 8.5.3 Acute dermal toxicity Moore GE Acute dermal toxicity study in rats - rat Product Safety Lab no: 19316 55 14887-42-4 2006 DSW IP55…19316 potassium pentahydrogen bis(phosphate) Limit test Laboratories (for DSW) 8.2 Eye Irritation Moore GE Primary eye irritation study in rabbits rabbit Product Safety Lab no: 19317 55 14887-42-4 2006 DSW IP55…19317 potassium pentahydrogen bis(phosphate) Laboratories (for DSW) 8.5.1 Acute oral toxicity Moore GE Acute toxicity up and down rat Lab no: 19315 Product Safety 55 14887-42-4 2006 procedure DSW IP55…19315 Laboratories (for DSW) potassium pentahydrogen bis(phosphate) 8.1 Skin irritation Moore GE Primary skin irritation study in rabbit Product Safety Lab no: 19318 55 14887-42-4 2006 rabbits DSW IP55…19318 potassium pentahydrogen bis(phosphate) Laboratories (for DSW) 7.7 Water solubility Mollandin G Determination of the water solubility n/a Institut fur Biologische project No: 50796185 55 14887-42-4 2009 of potassium pentahydrogen 50796185 final.pdf analytik (For Rotem potassium pentahydrogen bis(phosphate) bis(phosphate) Amfert Negev LTD) 7.16 Dissociation constant Fieseler A Dissociation constant n/a Institut fur Biologische project No: 50790194 55 14887-42-4 2009 50790194 Final.pdf analytik (For Rotem potassium pentahydrogen bis(phosphate) Amfert Negev LTD) magnesium pyrophosphate 57 13446-24-7 7.7 Water solubility O'Connor B 2009 A6 Water Solubility N/A IP Consortium Harlan 2920/0093 magnesium pyrophosphate 57 13446-24-7 8.1 Skin corrosion Warren N 2011 OECD 431 - In vitro skin corrosion N/A IP Consortium Harlan 2920/0154 8.1 Skin corrosion Warren N OECD 431 - In vitro skin corrosion RHE tissues 41205132 57 13446-24-7 2013 IP Consortium Harlan magnesium pyrophosphate 8.5.1 Acute oral toxicity Entzian K OECD 423 - Acute oral toxicity (Class rat 2010080293 58 20768-12-1 2011 Budenheim Bioserv GMBH magnesium dihydrogen pyrophosphate method) magnesium dihydrogen pyrophosphate 58 20768-12-1 8.4.3 In vitro gene mutation study in mammalian Entzian K 2011 OECD 476 - Mouse Lymphoma Assay mouse Budenheim Bioserv GMBH 2010080293 8.1 Skin irritation Entzian K Budeheim Bioserv Magnesium pyro rabbit 2010080293 58 20768-12-1 2011 Budenheim Bioserv GMBH magnesium dihydrogen pyrophosphate IP58 tests report 2010: skin irritation 8.2 Eye Irritation Entzian K Budeheim Bioserv Magnesium pyro rabbit 2010080293 58 20768-12-1 2011 Budenheim Bioserv GMBH magnesium dihydrogen pyrophosphate IP58 tests report 2010: eye irritation 8.1 Skin corrosion Warren N OECD 431 - In vitro skin corrosion in vitro tissues 2920/0155 58 20768-12-1 2011 IP Consortium Harlan magnesium dihydrogen pyrophosphate 8.5.1 Acute oral toxicity Bradshaw J OECD 420 - Acute oral toxicity RAT 41205131 58 20768-12-1 2013 IP Consortium Harlan magnesium dihydrogen pyrophosphate magnesium dihydrogen pyrophosphate 58 20768-12-1 8.1 Skin irritation Warren N 2013 OECD 439 - In vitro skin irritancy RHE tissues IP Consortium Harlan 41205133 8.2 Eye Irritation Warren N OECD 437 - BCOP bovine eyes 41205134 58 20768-12-1 2013 IP Consortium Harlan magnesium dihydrogen pyrophosphate 7.2 Melting/freezing point Walker J A6 Melting/Freezing Temperature N/A 3178/0001 60 not applicable 2010 TIMAB Harlan reaction mass of MCP and DCP 7.4 Relative Density Walker J OECD 109 - Relative density N/A 3178/0001 60 not applicable 2010 TIMAB Harlan reaction mass of MCP and DCP 7.7 Water solubility Walker J A6 Water Solubility N/A 3178/0001 60 not applicable 2010 TIMAB Harlan reaction mass of MCP and DCP 8.5.1 Acute oral toxicity Sanders A OECD 420 - Acute oral toxicity rat 3178/0002 60 not applicable 2010 TIMAB Harlan reaction mass of MCP and DCP

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Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year 8.1 Skin irritation Warren N OECD 439 - In vitro skin irritancy N/A 3178/0004 60 not applicable 2010 (B.46) TIMAB Harlan reaction mass of MCP and DCP 8.1 Skin corrosion Warren N OECD 431 - In vitro skin corrosion N/A 3178/0003 60 not applicable 2010 TIMAB Harlan reaction mass of MCP and DCP 8.2 Eye Irritation Warren N Reconstructed Human Corneal Model tissues 3178/0006 60 not applicable 2010 TIMAB Harlan reaction mass of MCP and DCP 8.2 Eye Irritation Sanders A OECD 405 - Acute eye irritation rabbit 3178/005 60 not applicable 2010 TIMAB Harlan reaction mass of MCP and DCP 7.4 Relative Density Hollerauer S DIN 51057 - determination of density N/A Clariant: Not provided 20120411083806700 64 12037-47-7 2011 Sud Chemie silicon orthophosphate - see SiPO4 dosser 7.14 Granulometry Clariant PSD determination N/A Clariant: Not provided 150 64 12037-47-7 2012a Sud Chemie silicon orthophosphate - see SiPO4 dosser 7.14 Granulometry Clariant PSD determination N/A 150 Clariant: Not provided 64 12037-47-7 2012b Sud Chemie - see SiPO4 dosser silicon orthophosphate 7.7 Water solubility Hollerauer S OECD 105: Water solubility N/A Clariant: Not provided NO NUMBER 64 12037-47-7 2012 Sud Chemie silicon orthophosphate - see SiPO4 dosser 8.5.3 Acute dermal toxicity Lütkenhaus K OECD 402 - Acute dermal rat Clariant: Not provided 122204 64 12037-47-7 2012 BSL Bioservice silicon orthophosphate - see SiPO4 dosser 8.2 Eye Irritation Lütkenhaus K OECD 437 - BCOP bovine eyes Clariant: Not provided 122205 64 12037-47-7 2012 BSL Bioservice silicon orthophosphate - see SiPO4 dosser silicon orthophosphate 64 12037-47-7 8.3 Skin sensitisation Lütkenhaus K 2012 OECD 429 - LLNA N/A Clariant: Not provided BSL Bioservice 122206 8.4.1 In vitro gene mutation study in bacteria Schreib G AMES N/A Clariant: Not provided 122207 64 12037-47-7 2012 BSL Bioservice silicon orthophosphate - see SiPO4 dosser ammonium polyphosphate 65 68333-79-9 8.5.1 Acute oral toxicity Bradshaw J 2015 OECD 420 - Acute oral toxicity rat IP Consortium Harlan 41403559 7. physicochemical properties - various O'Connor B Method A1 - Melting Point n/a 41403558 65 68333-79-9 2015 IP Consortium Harlan ammonium polyphosphate Method A3 Relative Density ammonium polyphosphate 65 68333-79-9 8.2 Eye irritation Bradshaw J 2015 OECD 405 - Acute eye irritation rabbit IP Consortium Harlan 41403563 ammonium polyphosphate 65 68333-79-9 8.1 Skin corrosion Warren N 2015 OECD 431 - In vitro skin corrosion N/A IP Consortium Harlan 41403560 8.5.2 Acute inhalation toxicity Griffiths DR OECD 436 - Acute inhalation rat 41403565 65 68333-79-9 2015 IP Consortium Harlan ammonium polyphosphate 7.4 Relative Density Wagner V OECD 109 - Relative density n/a Project 108321182 66 14940-41-1 2015 Budenheim Ibacon GmbH Triiron bis(orthophosphate) 7.10 Flammability Wagner V A.10 Determination of flammability N/A Project 108321187 66 14940-41-1 2015 Budenheim Ibacon GmbH Triiron bis(orthophosphate) 7.12 Auto-flammability Wagner V A.16 Determination of the relative n/a Project 108321188 66 14940-41-1 2015 self-ignition temperature Budenheim Ibacon GmbH Triiron bis(orthophosphate) Triiron bis(orthophosphate) 66 14940-41-1 7.1 Physical state, colour and odour Wagner V 2015 EPA Guidelines N/A Budenheim Ibacon GmbH Project 108321203 7.2 Melting point Wagner V OECD 102 - Melting Point n/a Project 108321180 66 14940-41-1 2015 Budenheim Ibacon GmbH Triiron bis(orthophosphate) 7.7 Water solubility Klawonn Th OECD 105 - Water solubility n/a BUD-011/1-34

2015/20 66 14940-41-1 Budenheim Fraunhofer IME 16

Triiron bis(orthophosphate)

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Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year 7.14 Particle size distribution Ahrens A OECD 110 - Particle size distribution n/a Project 108321360

2015/20 66 14940-41-1 Budenheim Ibacon GmbH 16

Triiron bis(orthophosphate) 8.5.1 Acute oral toxicity Entzian K OECD 423 - Acute oral toxicity (Class rat 69211-20-165-2015110892 method) 66 14940-41-1 2016 Budenheim Bioserv

Triiron bis(orthophosphate) 8.1 Skin irritation Prietzsch H OECD 404 - Acute dermal irritation rabbit 69211-20-128-2015110892 66 14940-41-1 2016 Budenheim Bioserv Triiron bis(orthophosphate) Triiron bis(orthophosphate) 66 14940-41-1 8.2 eye irritation Prietzsch H 2016 OECD 405 - Acute eye irritation rabbit Budenheim Bioserv 69211-20-133-2015110892 Triiron bis(orthophosphate) 66 14940-41-1 8.4.1 In vitro gene mutation study in bacteria [not known] 2016 OECD 471 - AMES s. typhimurium Budenheim LPT [not known] Triiron bis(orthophosphate) 66 14940-41-1 8.4.2 In vitro micronucleus [not known] 2016 OECD 487 - In vitro mouse Human Budenheim LPT [not known] 8.4.3 In vitro gene mutation study in mammalian [not known] OECD 476 - Mouse Lymphoma assay mouse [not known] 66 14940-41-1 2016 Budenheim LPT Triiron bis(orthophosphate) cells lymphoma cell diphosphoric acid, ammonium salt 67 22690-73-9 8.1 Skin irritation Warren N 2015 OECD 439 - In vitro skin irritancy N/A IP Consortium Harlan 41403937 8.2 eye irritation Warren N OECD 437 - BCOP N/A 41403938 67 22690-73-9 2015 IP Consortium Harlan diphosphoric acid, ammonium salt 7.2 Melting point Wagner V OECD 102 - Melting Point n/a Project 108301180 69 13573-12-1 2016 Budenheim Ibacon GmbH Magnesium dimetaphosphate 7.7 Water solubility Klawonn Th OECD 107 - Water Solubility n/a BUD-010/1-34 69 13573-12-1 2016 Budenheim Fraunhofer IME Magnesium dimetaphosphate 7.4 Relative Density Wagner V OECD 104 - Relative Density n/a Project 108331182 69 13573-12-1 2016 Budenheim Ibacon GmbH Magnesium dimetaphosphate Magnesium dimetaphosphate 69 13573-12-1 7.10 Flammability Wagner V 2016 A.10 - Flammability n/a Budenheim Ibacon GmbH Project 108331187 7.12 Auto-flammability Wagner V A.16 Determination of the relative n/a Project 108331188 69 13573-12-1 2016 Budenheim Ibacon GmbH Magnesium dimetaphosphate self-ignition temperature Magnesium dimetaphosphate 69 13573-12-1 7.1 Physical state, colour and odour Wagner V 2016 EPA Guidelines n/a Budenheim Ibacon GmbH Project 108331203 7.2 Melting point Wagner V OECD 102 - Melting Point n/a Project 108331180 70 13477-39-9 2016 Budenheim Ibacon GmbH Calcium bis(metaphosphate) 7.7 Water solubility Klawonn Th OECD 107 - Water Solubility n/a BUD-012/1-34 70 13477-39-9 2016 Budenheim Fraunhofer IME Calcium bis(metaphosphate) 7.4 Relative Density Wagner V OECD 104 - Relative Density n/a Project 108301182 70 13477-39-9 2016 Budenheim Ibacon GmbH Calcium bis(metaphosphate) Calcium bis(metaphosphate) 70 13477-39-9 7.10 Flammability Wagner V 2016 A.10 - Flammability n/a Budenheim Ibacon GmbH Project 108301187 7.12 Auto-flammability Wagner V A.16 Determination of the relative n/a Project 108301188 70 13477-39-9 2016 Budenheim Ibacon GmbH Calcium bis(metaphosphate) self-ignition temperature 7.1 Physical state, colour and odour Wagner V EPA Guidelines n/a Project 108301203 70 13477-39-9 2016 Budenheim Ibacon GmbH Calcium bis(metaphosphate) 7.14 Particle size distribution Ahrens A OECD 110 - Particle size distribution n/a [not provided by sponsor] 71 13466-20-1 2016 Budenheim Ibacon GmbH Barium bis (dihydrogenorthophosphate) 7.4 Relative Density Wagner V OECD 104 - Relative Density n/a Project 108281182 71 13466-20-1 2016 Budenheim Ibacon GmbH Barium bis (dihydrogenorthophosphate) 7.10 Flammability Wagner V A.10 Determination of flammability N/A Project 108321187 71 13466-20-1 2015 Budenheim Ibacon GmbH Barium bis (dihydrogenorthophosphate) Barium bis (dihydrogenorthophosphate) 71 13466-20-1 7.12 Auto-flammability Wagner V 2015 A.16 Determination of the relative n/a Budenheim Ibacon GmbH Project 108321188

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Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year 7.1 Physical state, colour and odour Wagner V EPA Guidelines N/A Project 108321203 71 13466-20-1 2015 Budenheim Ibacon GmbH Barium bis (dihydrogenorthophosphate) 7.2 Melting point Wagner V OECD 102 - Melting Point n/a Project 108321180 71 13466-20-1 2015 Budenheim Ibacon GmbH Barium bis (dihydrogenorthophosphate) Barium bis (dihydrogenorthophosphate) 71 13466-20-1 7.7 Water solubility Klawonn Th 2015/20 OECD 105 - Water solubility n/a Budenheim Fraunhofer IME BUD-011/1-34 7.14 Particle size distribution Ahrens A OECD 110 - Particle size distribution n/a [not provided by sponsor] 72 13762-83-9 2016 Budenheim Ibacon GmbH Barium dimetaphosphate 7.4 Relative Density Wagner V OECD 104 - Relative Density n/a [not provided by sponsor] 72 13762-83-9 2016 Budenheim Ibacon GmbH Barium dimetaphosphate 7.10 Flammability Wagner V A.10 Determination of flammability N/A [not provided by sponsor] 72 13762-83-9 2015 Budenheim Ibacon GmbH Barium dimetaphosphate Barium dimetaphosphate 72 13762-83-9 7.12 Auto-flammability Wagner V 2015 A.16 Determination of the relative n/a Budenheim Ibacon GmbH [not provided by sponsor] Barium dimetaphosphate 72 13762-83-9 7.1 Physical state, colour and odour Wagner V 2015 EPA Guidelines N/A Budenheim Ibacon GmbH [not provided by sponsor] Barium dimetaphosphate 72 13762-83-9 7.2 Melting point Wagner V 2015 OECD 102 - Melting Point n/a Budenheim Ibacon GmbH [not provided by sponsor] 7.7 Water solubility Klawonn Th 2015/20 OECD 105 - Water solubility n/a [not provided by sponsor] 72 13762-83-9 Budenheim Fraunhofer IME Barium dimetaphosphate 16 8.4.1 In vitro gene mutation study in bacteria Totaro K AMES n/a Proprietary 05-05-001 Next Century - 2002 information - not Incorporated aluminium polyphosphate owned by IP 8.5.1 Acute oral toxicity Younger F.M. single oral dose Rats Y-65-176 mix NA 1965 BK7 Younger Lab deicer ID1352D 8.5.3 Acute dermal toxicity Younger F.M. acute skin absorption minimal lethal Rabbits Y-65-176 mix NA 1965 BK7 Younger Lab deicer ID1352D dose 8.1 Skin irritation Younger F.M. In vivo skin irritation - rabbits Rabbits Y-65-176 mix NA 1965 BK7 Younger Lab deicer ID1352D 8.2 Eye Irritation Younger F.M. Eye irritation rabbits Rabbits Y-65-176 mix NA 1965 BK7 Younger Lab deicer ID1352D 8.5.1 Acute oral toxicity Bullard C Acute oral LD50, males Rat T-1255 n/a unknown 1968 PS-2818 Stauffer Western RC by-product of phosphoric acid' Super phosphoric acid N/A ? 8.1 Skin irritation Bullock CH and 1972 In vivo skin irritation - rabbits rabbit PS-2864 Stauffer Western RC T-4050 N/A Heil J N/A N/A T-4817 N/A N/A 1974 PS-2824 Stauffer Western RC sodium hypophosphite 8.5.1 Acute oral toxicity Kamienski FX Toxicology lab report rat T-1680 N/A 10045-87-1 1971 PS-2839 Stauffer Western RC sodium iron pyrophosphate sodium iron pyrophosphate N/A 10045-87-1 8.5.3 Acute dermal toxicity Kamienski FX 1971 Toxicology lab report rabbit PS-2839 Stauffer Western RC T-1680 sodium iron pyrophosphate N/A 10045-87-1 8.1 Skin irritation Kamienski FX 1971 In vivo skin irritation - rabbits rabbit PS-2839 Stauffer Western RC T-1680 8.2 Eye Irritation Kamienski FX Toxicology lab report rabbit T-1680 N/A 10045-87-1 1971 PS-2839 Stauffer Western RC sodium iron pyrophosphate 8.5.1 Acute oral toxicity Kamienski FX Toxicology lab report rat T-1680 N/A ? 1971 PS-2839 Stauffer Western RC potassium polymetaphosphate 8.5.3 Acute dermal toxicity Kamienski FX Toxicology lab report rabbit T-1680 N/A ? 1971 PS-2839 Stauffer Western RC potassium polymetaphosphate 8.1 Skin irritation Kamienski FX In vivo skin irritation - rabbits rabbit T-1680 N/A ? 1971 PS-2839 Stauffer Western RC potassium polymetaphosphate 8.2 Eye Irritation Kamienski FX Toxicology lab report rabbit T-1680 N/A ? 1971 PS-2839 Stauffer Western RC potassium polymetaphosphate 9.1.3 Short-term toxicity testing on fish ? OECD 203 (static) fish: Rainbow 46203 N/A 12593-60-1 2000 TFI/EFMA ABC laboratories sulfate trout Ammonium phosphate sulfate N/A 12593-60-1 8.5.1 Acute oral toxicity ? 2000 Acute oral toxicity up and down rat TFI/EFMA ABC laboratories 9732

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Endpoint Authors Study Test Guideline organism tested ce Study n° substance sub ID CAS Nr. Lab Year 9.1.2 Growth inhibition study in aquatic plants Aufderheide JA, Toxicity of granular triple sugar Algae 46208 N/A 65995-95-4 Bussard JB 2000 phosphate (GTSP) to unicellular TFI/EFMA ABC laboratories TSP green alga, Selenastrum 8.4.2 In vitro cytogenicity study in mammalian cells Gudi R & Brown C In vitro mammalian chromosome Mammalian cell AA43RC.331.BTL abberation test line - CHO N/A 65995-95-5 2001 TFI/EFMA BioReliance TSP TSP N/A 65995-95-6 8.4.1 In vitro gene mutation study in bacteria Wagner VO & Klug ML 2001 Bacterial reverse mutation assay Bacteria TFI/EFMA BioReliance 22949 8.7.1 Screening for reproductive developmental Dent MP 4-week general toxicity and Rat 22949 N/A 65995-95-7 2002 TFI/EFMA HLS TSP toxicity reproductive / development toxicity All substances n/a not applicable 7.16 Dissociation constant O'Connor B 2009 Dissociation constant N/A IP Consortium Harlan 2920/0036 Group 1: orthophosphates n/a not applicable 7.13 Oxidising properties O'Connor B 2009 Oxidising properties expert N/A IP Consortium Harlan 2920/0035 7.11 Explosive properties O'Connor B Explosivity expert statement N/A 2920/0035 n/a not applicable 2009 IP Consortium Harlan Group 1: orthophosphates TBC -Group 2: diphosphates n/a not applicable 9.2.2.1 Hydrolysis as a function of pH O'Connor B 2009 Hydrolysis as a function of pH N/A IP Consortium Harlan Group 2: diphosphates n/a not applicable 7.13 Oxidising properties O'Connor B 2009 Oxidising properties expert N/A IP Consortium Harlan 2920/0052 Group 2: diphosphates n/a not applicable 7.11 Explosive properties O'Connor B 2009 Explosivity expert statement N/A IP Consortium Harlan 2920/0052 TBC -Group 3: triphosphates n/a not applicable 9.2.2.1 Hydrolysis as a function of pH O'Connor B 2009 Hydrolysis as a function of pH N/A IP Consortium Harlan Group 2: triphosphates n/a not applicable 7.13 Oxidising properties O'Connor B 2009 Oxidising properties expert N/A IP Consortium Harlan 2920/0060 7.11 Explosive properties O'Connor B Explosivity expert statement N/A 2920/0060 n/a not applicable 2009 IP Consortium Harlan Group 2: triphosphates HiPeak - mixtue of MKP and DKP N/A N/A 9.1.3 Short-term toxicity testing on fish Priestly S 2010 OECD 203 (semi-static) fish: rainbow Rotem Amfert Harlan 3113/0002 9.1.1 Short term toxicity testing on invertebrates Priestly S OECD 202 - Acute toxicity in daphnia Daphnia magna 3113/0003 N/A N/A 2010 Rotem Amfert Harlan HiPeak - mixtue of MKP and DKP HiPeak - mixtue of MKP and DKP N/A N/A 9.1.2 Growth inhibition study in aquatic plants vryenhoef H 2010 OECD 201 - Algal growth inhibition algae Rotem Amfert Harlan 3113/0004 8.7.1 Screening for reproductive developmental Schardain JL One generation reproduction study rat IR-82-215 n/a n/a 1985 Monsanto IRDC Monsanto company Elemental phosphorus toxicity in rats with elemental phosphorus 8.6.1 Short-term repeated dose toxicity Hodge C.H. pilot toxicity test Rats NA 1956 H1 Uni Rochester orthophosphate sodium tetrametaphosphate NA 20758-95-6 8.6.1 Short-term repeated dose toxicity Hodge C.H. 1956 pilot toxicity test Rats H1 Uni Rochester 0 orthophosphate NA 0 8.6.1 Short-term repeated dose toxicity Hodge C.H. 1956 pilot toxicity test Dogs H1 Uni Rochester 0 8.6.1 Short-term repeated dose toxicity Hodge C.H. pilot toxicity test Dogs 0 NA 20758-95-6 1956 H1 Uni Rochester sodium tetrametaphosphate Eutrophication De Madariaga Europhication risk assessment NA 0 NA 2007 I3 INIA phosphates solid' 8.2 Eye Irritation Imlay P and Parke G 1977 Report on rabbit eye irritation rabbit PS-3706 Cannon (for Mobil) M1922-77 Not Specified - test material reported to be 'black rubber- 8.5.1 Acute oral toxicity Terrel Y and Parke G Report on Oral LD50 in rats. rat lab no. 7E-7003 1977 PS-3707 Cannon (for Mobil) like squares' Compound: MCTR-192-77 8.5.1 Acute oral toxicity Imlay P and Parke G Report on oral LD50 in rats. rat M1921-77 1977 AW_Oral LD50…. Cannon (for Mobil) Not specified - no indication of test material Compound: MCTR-192-77 solid' 8.1 Skin irritation Imlay P and Parke G 1977 Report on primary dermal irritation rabbit AW_Primary dermal… Cannon (for Mobil) M1924-77 Not specified - no indication of test material 8.1 Skin irritation Becker J and Parke G 1976 Report on primary dermal irritation rabbit CL_M512-76 Cannon (for Mobil) M512-76 7.4 Relative Density Fieseler A Determination of the relative density n/a Institut fur Biologische project No: 50794182 2009 of potassium pentahydrogen analytik (For Rotem 9.1.1 Short term toxicity testing on invertebrates Migchielsen MHJ OECD 202 - Acute toxicity in daphnia Daphnia magna [unknown] 2007 YARA Yara nitric acid, ammonium calcium salt 8.3.1 Skin sensitisation Grummer B OECD 406 - Guinea-pig maximisation guinea pig 69211-20-147-2015110892 14940-41-1 2016 Budenheim Bioserv test

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

sodium tripolyphosphate the toxicity of synthetic detergents (STPP) 0 7758-29-4 Henderson C. et al 1959 and soaps to fish fish sewage and industrial wastes 31: 295-306

sodium tripolyphosphate Detergent phosphorus effect on (STPP) 0 7758-29-4 Maloney T E 1966 algae. algae Journal of water pollutant control fed.38.38-45

Effect of Sodium tripolyphosphate (STPP) on the embryonic sodium tripolyphosphate Sinha P. and Kanamadi developmental stages of Zebrafish (STPP) 0 7758-29-4 R.D. 2000 Brachydanio rerio fish Environment and ecology 18(4): 1007-1010 Studies on the occurrence and sodium tripolyphosphate Engelbrecht R S and degradation of condensed phosphate (STPP) 0 7758-29-4 Morgan J J 1959 in surface waters. water Sewage and industrial wastes.31. sodium tripolyphosphate Kinetic studies on the hydrolysis of (STPP) 0 7758-29-4 Zinder B. et al 1984 STPP in sterile solution water water res. 18: 509-512 de Madariaga B.M., Ramos M.J. and Tarazona J.V Risk Assessment on EU phosphate consumption, effects assessment is Green Plant Research Report GPR-CEEP-07-1- sodium tripolyphosphate based on validated field studies.- Expanded Final Report. (also Layman's (STPP) 0 7758-29-4 2007 CEFIC sector group study N/A Summary of Report) Inman M.P., Beattie J.K., Abiotic hydrolysis of the detergent sodium tripolyphosphate Jones D.R., and Baldwin builder tripolyphosphate by hydrous (STPP) 0 7758-29-4 D.S. 2001 manganese dioxide. water Wat. Res. 35,8:1987-1993 sodium tripolyphosphate Sodium Tri(poly)phosphate in the (STPP) 0 7758-29-4 Lyons JW 1964 Kaolinite Water System. Clays Journal of Colloid Science 19: 399-412 sodium tripolyphosphate effects of synthetic detergents on (STPP) 0 7758-29-4 Smith R.S. Et al 1956 water coagulation water j am wat wks ass 48: 55-69 sodium tripolyphosphate The hydrolysis of sodium (STPP) 0 7758-29-4 Sutton A.H 1973 triphosphate in cod and beef muscle. cod J. Fd Technol., 8: 185-195

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

De Jager H and Heyns A M sodium tripolyphosphate Kinetics of acid-catalysed hydrolysis (STPP) 0 1998 of a polyphosphate in water. N/A J.phys.chem.102.2838-2841. Hydrolysis of triphosphate from Halliwell DJ, Mckelvie ID, detergents in a rural waste water sodium tripolyphosphate 0 Hart BT, Dunhill RH system N/A Wat. Res. 35(2): 448-454 Kulaev AS and Vagabov Polyphosphate metabolism in micro- STPP, 0 7758-29-4 VM 1983 organisms. n/a Advances in Microbial Physiology, 24: 83-171 A study of the substrate specificity Heppel LA, Harkness DR and othe properties of the alkaline The Journal of Biological Chemistry, 237(3): STPP, 0 7758-29-4 and Hilmoe RJ 1962 phosphatase of Escherichia coli. E.coli 841-846 Polyphosphate glucokinase from The Journal of Biological Chemistry, 261(10): STPP, 0 7758-29-4 Pepin CA and Wood HG 1986 Propionibacterium shermanii bacteria 4476-4480

Hydrolytic and enzymatic breakdown of food grade condensed phosphates Dissertation Abstracts International B47(): STPP, 0 7758-29-4 Reddy BR 1987 in white shrimp (Penaeus Setiferus). shrimp 4716 effect of the chelating agent sodium sodium tripolyphosphate Adersen, O. Hagerstrand I., triphosphate on cadmium toxicity in (STPP) 0 7758-29-4 Nordberg G.F. 1982 mice mice environmental research 29, 54-61 sodium tripolyphosphate Environmental Health Perspectives. 54: 249- (STPP) 0 7758-29-4 Andersen O et al 1984 Chelation of cadmium review N/A 266 sodium tripolyphosphate Andersen, O., Nielsen, oral cadmium chloride intoxication in (STPP) 0 7758-29-4 J.B., Svendsen. P. 1988 mice: effects of chelation by STPP mice Toxicology, 52: 65-79 Regulation of Resting and IL-2 activated Human Cytotoxic Lymphocytes by Exogenous sodium tripolyphosphate Nucleotides: Role of IL-2 and Ecto- venous blood (STPP) 0 7758-29-4 Bajpai. A., Brahmi Z. 1993 ATPases human cellular immunology 148: 130-143 Mobilization of some metals in water sodium tripolyphosphate and animal tissues by NTA, EDTA sediments, (STPP) 0 7758-29-4 Barica J. et al 1973 and TPP crayfish, fish Water res. 7: 1791-1804 Akute orale toxizitat von natriumtripolyphosphate an Sodium tripolyphosphate mannlichen und weilichen beagle- (STPP) 0 7758-29-4 Clairiant Hoescht 1975 hunden dog

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Field evalution of fluorescent whitening agent and sodium sodium tripolyphosphate triphosphate as indictators of septic New Zealand journal of marine and freshwater (STPP) 0 7758-29-4 Close M et al 1989 tank contamination in domestic wells water Research:23.563-568 sodium tripolyphosphate Respiratory toxicity of enzyme Cynomologus Toxicology and applied pharmcology 45.471- (STPP) 0 7758-29-4 Coate W B et al 1978 detergent dust Monkeys 496. sodium tripolyphosphate The of sodium (STPP) 0 7758-29-4 Corbridge D E C 1960 triphosphate, Na5P3O10 phase I. n/a Acta Cryst.13,263. The crystal structure of sodium sodium tripolyphosphate Davies D R and Corbridge tripolyphosphate, Na5P3O10 phase (STPP) 0 7758-29-4 D E C 1958 II. n/a Acta Cryst.11,315. sodium tripolyphosphate Dymon J J and King A J Structure studies of the two forms of (STPP) 0 7758-29-4 1951 sodium tripolyphosphate. n/a Acta Cryst.4.378

Effects of detergent formula chelating sodium tripolyphosphate agents on the metabolism and (STPP) 0 7758-29-4 Engstrom B et al 1978 toxicity of Cadmium in mice. mice Acta pharmacol et toxicol.43.387-397 Effects of chelating agents on oral sodium tripolyphosphate uptake and renal deposition and (STPP) 0 7758-29-4 Engstrom B. 1984 excretion of cadmium mice Environmental Health perspective 54: 219-232 Effects of chelating agents on oral sodium tripolyphosphate uptake and renal deposition and (STPP) 0 7758-29-4 Engstrom B. 1984 excretion of cadium. mice Environmental health perspectives.54.219-232.

Effects of detergent formula chelating sodium tripolyphosphate Engstrom B., Nordberg. agents on the metabolism toxicity of (STPP) 0 7758-29-4 G.F. 1978 cadmium in mice mice Acta pharmacol. Et toxicol. 43: 387-397 sodium tripolyphosphate FDA STPP authorisation (STPP) 0 7758-29-4 21.182.1810.pdf ? ? ? 21 CFR Ch 1. (4-1-02 Edition), 45 sodium tripolyphosphate ökologische und toxicologische Betrachtung. (STPP) 0 7758-29-4 Foroutan-Rad M 1981 ? Umwelt 3: 218-224

The solution properties of supersaturated sodium tripolyphosphate sodium triphosphate forms I and II. (STPP) 0 7758-29-4 Griffith EJ and Metcalf JS 1993 physiochemical properties n/a Phosphorus, Sulphur and Silicon. 76:175-178. sodium tripolyphosphate The Chemical and Physical Properties of (STPP) 0 7758-29-4 Griffiths EJ 1975 physiochemical properties n/a Condensed Phosphates, 173-200

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Study of sodium tripolyphosphate- Hsieh F.-M., Huang C., Lin crosslinked chitosan beads sodium tripolyphosphate T.-F., Chen Y.-M. and Lin entrapped with Pseudomonas putida (STPP) 0 7758-29-4 J.-C. 2008 for phenol degradation. N/A Process Biochemistry. 43:83-92 sodium tripolyphosphate Data book of chromosomal aberration test in (STPP) 0 13573-18-7 Ishidate M, Sofuni T. 1998 chromosom al aberration test in vitro In vitro vitro primary mutagenicity screening of sodium tripolyphosphate food additives currently used in hamster (STPP) 0 13573-18-7 Ishidate M. et al 1984 Japan fibroblasts Fd. Chem. Toxic. 22(8): 623-636 factors affecting sensitivity of sodium tripolyphosphate Staphylococcus aureus 196E to applied and environmental microbiology: 842- (STPP) 0 7758-29-4 Jen C.M.C, Shelef L.A. 1986 polyphosphates bacteria 846 sodium tripolyphosphate Manufacture of sodium triphosphates (STPP) 0 7558-29-4 King CS 1944 - patent n/a n/a K-Z A Compilation of Solubility Data from the sodium tripolyphosphate Inorganic and Metal- Periodical Literature Volume II 4th Edition. (STPP) 0 7758-29-4 Linke et al 1965 Organic Compounds water American Chemical Society Modeling of Exposure to Carpet- Cleaning Chemicals Preceding sodium tripolyphosphate Irritant Induced Asthma in One Environmental Health Perspectives, 108(9): (STPP) 0 7758-29-4 Lynch RM 2000 Patient. Human 911-913 sodium tripolyphosphate (STPP) 0 7758-29-4 Matiuchices V.B et al 1984 toxicologic caracterization of STPP rodents Gigiena i Sanitariya 15: 97-101 description of the toxicometric parameters of sodium sodium tripolyphosphate tripolyphosphate in Saccharomyces Vestnik Leningradskogo Universiteta Biologiya (STPP) 0 7758-29-4 Matyushichev VB et al 1984 cerevisiae yeast 3: 97-101 possible mechanism behind the adjuvant action of phosphate sodium tripolyphosphate derivatives on rectal absorption of J. of pharmaceutical Science 73(11): 1523- (STPP) 0 7758-29-4 Nishihata T. et al 1984 Cefoxitin in Rats and Dogs dog and rats 1525 Rabbits, sodium tripolyphosphate Evaultion of modified methods for Guinea-pigs, Regulatory toxicology and (STPP) 0 7758-29-4 Nixon G A.et al 1990 determining skin irritation. humans pharmacology.12.127-136 sodium tripolyphosphate Nixon G.A., Tyson C.A. Interspecies comparisons of skin Toxicology and applied pharmacology 31: 481- (STPP) 0 7758-29-4 And Wertz W.C. 1975 Irritancy Rabbits 490 sodium tripolyphosphate Nixon G.A., Tyson C.A. Interspecies comparisons of skin Toxicology and applied pharmacology 31: 481- (STPP) 0 7758-29-4 And Wertz W.C. 1975 Irritancy guinea pigs 490

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested sodium tripolyphosphate Nixon G.A., Tyson C.A. Interspecies comparisons of skin Toxicology and applied pharmacology 31: 481- (STPP) 0 7758-29-4 And Wertz W.C. 1975 Irritancy human 490

Determination of ortho-, pyro- and sodium tripolyphosphate tripolyphosphate by the use of a Journal unknown (Department of Chemistry, (STPP) 0 7758-29-4 Ohashi S and Takada S 1961 small column of ion-exchange resin N/A Kanazawa University), 34(10): 1516-1518 sodium tripolyphosphate The effect of tripolyphosphate and (STPP) 0 7758-29-4 Oshiba et al. 1979 phytate on mineral balance in rats Rats sikatsu eisei 23(6): 209 A thermal microscopic and X-ray sodium tripolyphosphate study of the system NaPO3- (STPP) 0 7758-29-4 Partiridge E P et al. 1941 Na4P2O7 n/a .Journal of American chemistry society.454 sodium tripolyphosphate Schaffer JR and Polyelectrolyte Builders as Detergent (STTP) 0 7758-29-4 Woodhams RT 1977 Phosphate Replacements N/A Ind Eng Chem Prod Res Dev, 16: 3-11

Solubility equilibria of sodium sulphate at temperatures from 150°C to 350°C. III. Effect of sodium sodium triphosphate 0 7758-29-4 Schroeder WC et al 1937 hydroxide and sodium phosphate. N/A J. Am. Chem. Soc. 59(10): 1783-1790 ) Hydrolytic degradation of sodium tripolyphosphate in concentrated sodium tripolyphosphate solutions and in presence of foreign (STPP) 0 Shen CY 1966 ions Ind Eng Chem Prod Res Dev 5: 97-100

The results of microbial mutation test sodium tripolyphosphate for forty-three industrial chemicals (STPP) 0 13573-18-7 Shimizu H. et al 1985 (salmonella and Escherichia coli) bacteria Jpn. J. Ind. Health 27: 400-419 Distinguishing human from animal sodium tripolyphosphate Sinton L.W., Finlay R.K faecal contamination in water: a New Zealand Journal of Marine and (STPP) 0 7758-29-4 and Hannah D.J 1998 review. water Freshwater Research, 32: 323-348 sodium tripolyphosphate Toxicology and Applied Pharmacology, 5: 176- (STPP) 0 7758-29-4 Synder et al 1963 Toxicologic Studi es on Brighteners. 18 sodium tripolyphosphate Soaps and Detergents and the (STPP) 0 7758-29-4 Taylor A. 1980 Environment. JAOCS, November 1980: 859A-861A sodium tripolyphosphate Phosphorus in Environmental Technology (STPP) 0 7758-29-4 Valsami-Jones E 2004 physiochemical properties n/a Principles and Applications . sodium tripolyphosphate Van Wazer jr and Structure and properties of the (STPP) 0 7758-29-4 Campanella D 1950 condensed phosphates III and IV substance itself J Amer Chem Soc 72: 647 - 663

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Toxicity of laundry detergent components to a freshwater sodium tripolyphosphate Warne M.J. And Schifko cladoceran and their contribution to Ecotoxicology and environment safety 44: 196- (STPP) 0 7758-29-4 A.D. 1999 detergent toxicity Crustaceans 206 Efficacy of soluble sodium sodium tripolyphosphate tripolyphosphate amendments for the (STPP) 0 7758-29-4 Wellman D.M. Et al 2007 in-situ mobilisation of uranium river sediment Environ. Chem. 4: 293-300 Toxicological evaluation of some sodium tripolyphosphate extraction solvents and certain other FAO Nutrition Meetings Report Series No. 48A. (STPP) 0 7758-29-4 WHO 1970 substances rat, rabbit WHO/FOOD ADD/70.39 change in size of casein micelles sodium tripolyphosphate caused by addition of cleaning agent (STPP) 0 7758-29-4 Wieczorek J. et al 1996 components casein Netherlands Milk and Dairy J. 50: 53-59 Assessing detergent safety: a comparison of a nonphosphate Type 1 detergent with laundry detergent with phosphate sodium tripolyphosphate 0 7758-29-4 Williams J.B. And Taber D. 1972 detergents Rats J am chem soc 49: 539-551 Assessing detergent safety: a comparison of a nonphosphate Type 1 detergent with laundry detergent with phosphate sodium tripolyphosphate 0 7758-29-4 Williams J.B. And Taber D. 1972 detergents dogs J am chem soc 49: 539-551 Assessing detergent safety: a comparison of a nonphosphate Type 1 detergent with laundry detergent with phosphate sodium tripolyphosphate 0 7758-29-4 Williams J.B. And Taber D. 1972 detergents Rabbits J am chem soc 49: 539-551 Assessing detergent safety: a comparison of a nonphosphate Type 1 detergent with laundry detergent with phosphate sodium tripolyphosphate 0 7758-29-4 Williams J.B. And Taber D. 1972 detergents Rabbits J am chem soc 49: 539-551 Assessing detergent safety: a comparison of a nonphosphate Type 1 detergent with laundry detergent with phosphate sodium tripolyphosphate 0 7758-29-4 Williams J.B. And Taber D. 1972 detergents Rabbits J am chem soc 49: 539-551 Assessing detergent safety: a comparison of a nonphosphate Type 1 detergent with laundry detergent with phosphate sodium tripolyphosphate 0 7758-29-4 Williams J.B. And Taber D. 1972 detergents Monkey J am chem soc 49: 539-551

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Assessing detergent safety: a comparison of a nonphosphate Type 1 detergent with laundry detergent with phosphate sodium tripolyphosphate 0 7758-29-4 Williams J.B. And Taber D. 1972 detergents human J am chem soc 49: 539-551 Assessing detergent safety: a comparison of a nonphosphate Type 1 detergent with laundry detergent with phosphate sodium tripolyphosphate 0 7758-29-4 Williams J.B. And Taber D. 1972 detergents human J am chem soc 49: 539-551 Assessing detergent safety: a comparison of a nonphosphate Type 1 detergent with laundry detergent with phosphate sodium tripolyphosphate 0 7758-29-4 Williams J.B. And Taber D. 1972 detergents human J am chem soc 49: 539-551 Assessing detergent safety: a comparison of a nonphosphate Type 1 detergent with laundry detergent with phosphate sodium tripolyphosphate 0 7758-29-4 Williams J.B. And Taber D. 1972 detergents human J am chem soc 49: 539-551

Research into the toxicity and effects Amoeba and of polyphosphates on growth of rotifer and cultures of amoeba, rotifers, Amphibian sodium tripolyphosphate tadpoles, and on the succession of (Bufo bufo and institut fur Landwirtschaftliche Zoologie und (STPP) 0 13573-18-7 Wuembach et al 1966 organisms in cellulose decomposition Xenopus laevis) bienenkunde, Report 33 pages Zettlemoyer AC and sodium triphosphate 0 7758-29-4 Schnieder CH 1956 The hydration of sodium phosphate N/A . J. Am. Chem. Soc. 78(16): 3870-3871 Effects of Potassium Sorbate and OtherAntibotulinal Agents on Germination and Outgrowth of Seward RA, Diebel RH, Clostridium botulinum Type E Spores Applied and evironmental microbiology. 44(5): sodium tripolyphosphate 0 Lindsay RC 1982 in Microcultures bacteria 1212-1221 The Effect of Food Grade Steinhauer JE and Banwart Polyphosphates on the Microbial sodium tripolyphosphate 0 GJ 1963 Population of Chicken Meat bacteria Poultry Science. 43:618-625 Teratologic evaluation of FDA 71-46 (sodium tripolyphosphate, sodium tripolyphosphate 0 7758-29-4 Morgareidge K 1973 anhydrous) rats/mice FDABF-GRAS-075 Calcium and Phosphorus Kincaid RL Hillers JK & Supplementation of Rations for sodium tripolyphosphate 0 7758-29-4 Cronrath JD 1981 Lactating Cows cows J Dairy Sci 64:754-758

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Archiv fur experimentelle Pathologie und disodium orthophosphate 2 munzer DE 1898 ? ? Pharmakologie 41: 74-96

Mutagenic evaluation of compound. S. typhimuium, monosodium phosphate FDA 73-2, monosodium phosphate Saccharomyces (MSP) 2 7558-80-7 Brusick D 1975 anhydrous powdered, FCC grade cerevisiae Litton Bionetics Inc. NTIS PB245508 Initial submission: Primary skin irritation of sodium monosodium phosphate Bullock CH and Kamienski hexametaphosphate, powdered, in Stauffer Western RC NTIS OTS0555931 (T- (MSP) 2 7558-80-7 FX 1972 rabbits Rabbits 1861) monosodium phosphate Enlargement of parathyroid glands (MSP) 2 13472-35-0 Fazekas, IG 1954 by simple acidic compounds rabbits J. Anim. Sci. 80:1690-1695 monosodium phosphate phosphate induced renal (MSP) 2 7558-80-7 Hitchman A.J. et al 1979 in the rat rats can j physiol pharmac 57(1):92 monosodium phosphate Injury to guinea pigs that follows a (MSP) 2 7558-80-7 House WB and Hogan AG 1955 high intake of phosphates Guinea pigs The Journal nutrition. 55:507-518 Mac Kay E M and Oilver J Renal damage following the injection ? monosodium phosphate of a diet containing an excess of (MSP) 2 7558-80-7 1935 inorganic phosphates. Journal of experimental medicine.61 Postnatal development of progeny after 5-HT and/or 32P treatment of monosodium phosphate 2 7558-80-7 Manowska J and Mazur L 1986 mice on the first day of gestation. mice Acta Physiologica Hungarica. 67(4): 419-422 monosodium phosphate experimental phosphate nephritis in (MSP) 2 7558-80-7 McFarlane D. 1941 the rat Rats J pathol. Bacteriol. 52: 17 Study of the genotoxic potential of 48 monosodium phosphate inorganic derivatives with the SOS (MSP) 2 7558-80-7 Olivier P. and Marzin D. 1987 chromotest bacteria Mutation research, 189(): 263-269

Triple Super Phosphate,. Ivy RE, Sulivan TW, DAP, sodium Goldner WJ, Graff CR & availability and toxicity of fertiliser dihydrogenorthophosphate 2 7558-80-7 Peo FR 1972 phosphates in the rat rat Poultry Science association meeting monosodium phosphate The toxic effect of some phosphate (MSP) 2 13472-35-0 McMeniman N.P. 1973 supplements fed to sheep sheep Australian Veterinarian J. 49: 150-152 Inorganic phosphate as a negative monosodium phosphate conditioning factor in plant cell (MSP) 2 7558-80-7 Sakano K. et al 1995 culture plant cells plant science 107: 117-124

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Effects of dietary energy and phosphorus content on blood N. F. Cymbaluk and G. I. chemistry and development of monosodium phosphate 2 7558-80-7 Christison 1989 growing horses horse J Anim Sci 1989. 67:951-958.

Phosphorus Partitioning During Early monosodium phosphate, Lactation in Dairy Cows Fed Diets dicalcium phosphate 2 7758-80-7 Knowlton KF and Herbin JH 2002 Varying in Phosphorus Content cows J. Dairy Sci. 85:1227–1236 Effect of Dietary Phosphorus on Lopez H, Kanitz FD, Performance of Lactating Dairy Moreria VR, Wiltbank VR Cows: Milk Production and Cow monosodium phosphate 2 7558-80-7 and Satter LD 2004 Health cows J. Dairy Sci. 87:139–146 Lopez H, Kanitz FD, Reproductive Performance of Dairy Moreria VR, Wiltbank VR Cows Fed Two Concentrations of monosodium phosphate 2 7558-80-7 and Satter LD 2004 Phosphorus cows Journal of Dairy Science 87(1) 146-157 Matsuzaki H, Katsumata S, High-Phosphorus Diet Induces Uehara M, Suzuki K, Miwa Osteopontin Expression of Renal monosodium phosphate 2 7558-80-7 M 2007 tubules in Rats rats (mutant) J. Clin. Biochem. Nutr., 41, 179–183, Milk Production, Estimated Phosphorus Excretion,and Bone Wu Z, Satter LD, Characteristics of Dairy Cows Fed Blohowiak AJ, Stauffacher Different Amounts of Phosphorus for monosodium phosphate 2 7558-80-7 RH and Wilson JH 2001 Two or Three Years cowx J. Dairy Sci. 84:1738–1748

Utilization of Phosphorus in Lactating wu Z, Tallam S, Ishler VA Cows Fed Varying Amounts of monosodium phosphate 2 7558-80-7 and Archibald DD 2003 Phosphorus and Forage cow J. Dairy Sci. 86:3300–3308 Milk Production, Reproductive Performance, and Fecal Excretion of Phosphorus by Dairy Cows Fed monosodium phosphate 2 7558-80-7 Wu Z, Satter LD & Sojo R 2000 Three Amounts of Phosphorus cow J Dairy Sci 83:1028–1041 correlation between the in vitro Brandao J.C., Bohets H.L., cytotoxicity to cultured fathead fish cells monosodium phosphate Van De Vyver I.E., Dierickx minnow fish cells and fish lethality (fathead (MSP) 2 7558-80-7 P.J. 1992 datas for 50 chemicals minnow) Chemosphere 25(4):553-562 (558)

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The thymidine incorporation inhibiting screening system (TSS) to test carcinogenic substances (A monosodium phosphate Amlacher E. and Rudolph nuclear DNA synthesis suppressive (MSP) 2 7558-80-7 C. 1981 short term test) mice Arch. Geschwulst. Forch. 51(7): 605-610 Influence of NaF and Na2PO3F on monosodium phosphate chemically induced aberrations in (MSP) 2 7558-80-7 Burki et al 1975 mature sperm of drosophila Drosphilia mutat res, 31: 315-316 Ittner J., Dambacher M.A., Muff R., Rüegsegger P., Reduced parathyroid hormone monosodium phosphate Trechsel U., and Fischer response to peroral phosphate in (MSP) 2 7558-80-7 J.A. 1986 osteoporotic patients. human Mineral Electrolyte Metab. 12:199-203 monosodium phosphate Karbe, K., und G. Jander Die Metaphosphate in KOLLOID- (MSP) 2 7558-80-7 1943 BEIHEFTE. Heft 1-4, p1-146 Heft 1-4, p1-146 Studies of hydroxy-aluminium phosphates obtained from pentahydroxy-dialuminum chloride monosodium phosphate 2 7558-80-7 Misheva E 1990 and monosodium phosphate N/A Arch. Pharm. 323: 447-451 Miyoshi K, Funahashi H, Development of rat one-cell embryos Okuda K and Niwa K in a chemically defined medium: monosodium phosphate effects of glucose, phosphate and rat (in vitro Journal of Reproduction and Fertility. 100:21- (MSP) 2 7558-80-7 1994 osmolarity. emvryo) 26 Rapidly labelled polyphosphates and monosodium phosphate metaphosphates in the Blue-Green (MSP) 2 7558-80-7 Niemeyer R. and Richter G. 1969 Alga Anacystis nidulans algae Arch. Mikrobiol 69: 54-59 anticariogenic effect in the rat of monosodium phosphate Stookey G.K. And Muhler cereals fortified with a soluble (MSP) 2 7558-80-7 J.C. 1965 phosphate Rats J. D. Res 45(3): 856-864 monosodium phosphate,calcium phosphate Handbook of poisoning: prevention, 2 7558-80-7 Unknown ? diagnosis and treatment. human Eleventh Edition. Lange Medical Publications. Specification for the identity and purity of food additives and their WHO IPCS INCHEM toxicological evaluation: Emulsifiers, identity purity food stabilizers, bleaching and maturing additives P-acid & agents. Who health organisation monosodium phosphate phosphates Tech report technical report series No281. guinea pig, (MSP) 2 7558-80-7 281 dated 1964 1964 rabbit, man WHO

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Phosphate supplementation in young monosodium phosphate Whybro A, Jagger H, men: lack of effect on calcium European Journal of Clinical Nutrition. 52: 29- (MSP) 2 7558-80-7 Barker M & Eastell R 1998 homeostasis and bone turnover. Man 33 Ricerche farmicologiche sul fosfato monosodium phosphate 2 7558-80-7 Gajatto DS 1939 monosodico ? Arch Farmacol Sper. 68:87-98 Agboola HA, Cahill VR, The effects of a high monosodium sodium Conrad HR, Ockerman phosphate and alpha tocopherol dihydrogenorthophosphate HW, Pareent NA and supplemented milk replacer diet on (MSP) 2 7558-80-7 Plimpton RF 1988 veal muscle color and composition. cow Journal of animal science. 66:1676-1685. sodium Draper HH, Sie TL and Osteoporosis in Aging Rats Induced dihydrogenorthophosphate 2 7558-80-7 Bergan JG 1972 by High Phosphorus Diets RAT J Nutr. 102: 1133-1142

Effects of calcium and phosphorous levels and diethylstilbestrol on urinary calculi incidence and feedlot monosodium phosphate 2 7558-80-7 Emerick RJ & Embry LB 1964 performance of lambs Sheep J Anim Sci. 23:1079-1083.

Schryver H, Hintz H and Calcium Metabolism in Ponies Fed a monosodium phosphate 2 7558-80-7 Craig P 1971 High Phosphorus Diet ponies J. NUTRITION,101: 259-264. sodium dihydrogenorthophosphate The primary lesion in phophate Journal of Pathology and Bacteriology. 43(2): (MSP) 2 7558-80-7 Duguid JB 1938 nephritis rat 321-326

Sodium dihydrogen phosphate Mono- and polyphosphates have (NaH2PO4.2H2O), sodium Karp HJ, Kemi VE, similar effects on calcium and tripolyphosphate Lamberg-Allardt JE & phosphorus metabolism in healthy (Na5P3O10) 2 7558-80-7 Karkkainen MUM 2012 young women Man Eur J Nutr [published online 05 July]

Factors which determine the Sodium concentration of calcium and of dihydrogenorthophosphate inorganic phosphorus in the blood Johns Hopkins Hospital Bulletin. September: (NaH2PO4) 2 7558-80-7 Kramer B & Howland J 1922 serum of rats Rat 313-317

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Phosphorus in the blood and urine: a study of the excretion and retention Acid sodium phosphate, 7558-80-7 of phosphorus in a normal subject alkaline sodium phosphate 2 13472-35-0 Schulz I 1930 and in patients with renal disease Man Ann Int Med. 3: 667-689 Ion association. VI. Interactions between calcium, magnesium, Monosodium phosphate inorganic phosphate, citrate and (NaHPO4-) 2 7558-80-7 Walser M 1961 protein in normal human plasma Man J Clin Invest. 40(4): 723-730 pH and conductivity of sodium National Technical Information Service Report Sodium phosphate 2 7558-80-7 Wright JM & VonNieda GE 1979 phosphate solutions N/A WAPD-TM-1302

High phosphorus intake only slightly dietary phosphate as affects serum minerals, urinary sodium Grimm M, Muller A, Hein pyridinium crosslinks and renal European Journal of Clinical Nutrition. 55: 153- dihydrogenorthophosphate 2 G, Funfstuck R & Jahreis G 2001 function in young women human 161

Evaluation of Meat and Bone Meal and Mono-Sodium Phosphate as Supplemental Dietary Phosphorus Sources for Broodstock Nile Tilapia Monosodium phosphate Mabroke RS, Tahoun AM, (Oreochromis niloticus) Under the Turkish Journal of Fisheries and Aquatic (NaHPO4-) 2 7758-80-7 Suloma A & El-Haroun ER 2013 Conditions of Hapa-in- Pond System fish Sciences 13: 11-18 Inorganic Phosphate as a Novel Spina A, Sapio L, Esposito Signaling Molecule with Monosodium phosphate A, Di Mailolo F, Sorvillo L & Antiproliferative Action in MDA-MB BioResearch Open Access Volume 0, Number (NaHPO4-) 2 7758-80-7 Naviglio S 2012 231 Breast Cancer Cells N/A 0, Month 2012 Call JW, Butcher JE, Clinical Effects of low dietary Shupe JL, Lamb RC, phosphorus concentrations in feed Monosodium phosphate 2 7758-80-7 Boman RL & Olson AE 1987 given to lactating dairy cows cows Am J Vet Res, 48(1): 133-136 Influence of Long-Term Feeding of Limited Amounts of Phosphorus on Dry Matter Intake, Milk Production, and Body Weaght of Monosodium phosphate 2 7758-80-7 Valk H & Sebek LBJ 1999 Dairy Cows cows J Dairy Sci 82:2157-2163

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Effects of Varying Amounts of Steevens BJ, Bush LJ, Calcium and Phosphorus in Monosodium phosphate 2 7758-80-7 Stout JD & Williams EI 1971 Rations for Dairy Cows cows J Dairy Sci 54(5): 655-661 Estrous Behavior and Endocrine Hurley WL, Edgerton LA, Status of Dairy Heifers with Varied Monosodium phosphate 2 7758-80-7 Olds D & Hemekn RW 1982 Intakes of Phosphorus cows J Dairy Sci 65:1979-1986

Effect of dietary phosphorus Lopez H, Wu Z, Satter LD concentration on estrous behavior of Monosodium phosphate 2 7758-80-7 & Wiltbank MC 2004 lactating dairy cows cows Theriogeoology 61 (2004) 437-445 minimal eventually lethal dose intravenous na2hpo4 acid sodium disodium phosphate (DSP) 3 7558-79-4 Osser S 1933 phosphate Rabbits arch ital sci farmacol 2(5)478-494 Modifications de la phosphatemie provoquees par l'ingestion journaliere disodium phosphate (DSP) 3 7558-79-4 Corbiau L 1936 de phosphate bisodique dog CR Soc Biol. 122: 474-475

Salmonella Mutagenicity test results environmental mutagenesis supplement 1: 3- disodium phosphate (DSP) 3 7558-79-4 Haworth S. et al 1983 for 250 chemicals (see subst. 216) bacteria 142 Initial submission: Primary skin irritation of sodium Bullock CH and Kamienski hexametaphosphate, powdered, in Stauffer Western RC NTIS OTS0555931 (T- disodium phosphate (DSP) 3 7558-79-4 FX 1972 rabbits Rabbits 1861) Erichsen Jones JR A study of the relative toxicity of anions, with polycelis nigra as test disodium phosphate (DSP) 3 7558-79-4 1941 animals. polycelis nigra Journal of Experimental Biology. 18: 170-181. tsuchiya N, Matsushima S, Glomerular calcification induced by Takasu N, kypkawa Y and bolus injection with dibasic sodium torii M phosphate solution in Sprague- disodium phosphate (DSP) 3 7558-79-4 2004 Dawley rats. rat Toxicologic Pathology. 32:408-412 Tsuchiya N, Tprii M, Early events involving glomerular Naramara I and Matsui T calcification induced by dibasic disodium phosphate (DSP) 3 7558-79-4 2008 sodium phosphate solution in rats. rat J Toxicol Pathol. 21: 229-237 Toxicity of ammonia, nitrite Ion, Nitrate Ion and orthophosphate to mercenaria mercenaria and institut fur Landwirtschaftliche Zoologie und disodium phosphate (DSP) 3 7558-79-4 Epifanio C.E., Sma R.F. 1975 crassostrea virginica clam and oyster bienenkunde, Report 33 pages

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High phosphorus intake depresses Schonewille JT, Klooster apparent magnesium absorption in J. Anim. Pysiol. a. Anim. Nutr. 71 (1994), 15- disodium phosphate (DSP) 3 7558-79-4 AT & Beynen AC 1993 pregnant heifers cow 21 Response of Rainbow Trout (Oncorhynchus mykiss) Growing from 50 to 200 g to Supplements of Dibasic Sodium Phosphate in a disodium phosphate 3 7558-79-4 Rodenhutscord M 1996 Semipurified Diet fish J. Nutr. 126: 324-331 Rabbit corneal irrigation as a model System for studies on the relative toxicity of bacterial products implicated in periodontal disease. The toxicity of neutralised ammonia disodium phosphate (DSP) 3 7558-79-4 Rizzo A.A. 1967 solutions Rabbits j. periodont 38: 491-499 disodium phosphate (DSP) 3 7558-79-4 Milani R 1946 Induction of mutations with Na3PO4 Drosphilia Drosophila Information Service. 20: 87 effects of sodium phosphates and calcium on the hormones disodium phosphate (DSP) 3 7558-79-4 Abelin. I. 1928 produced by the thyroid gland rats Biochem. Z. Bachrach L., Correa A., Iron poisoning: Complications of Levin R. and Grossman M. hypertonic phosphate lavage therapy. Brief clinical and laboratory disodium phosphate (DSP) 3 7558-79-4 1979 observations. The Journal of Pediatrics. 94,1:147-149 Scientia Genetica. Vol II. Milani R. Produzione di mutazioni letali in 1940- Drosophila melaongaster per mezzo disodium phosphate (DSP) 3 7558-79-4 Buzzati-traverso A 1946 di fosfato di sodio Drosphilia N/A Report of the scientific committee for food. 7th Series. Commission of the European communities. disodium phosphate (DSP) 3 7558-79-4 1978 N/A N/A N/aA disodium Influence of dietary calcium and hydrogenorthophosphate Sobel A, Wexler I, phosphorous upon action of vitamin (DSP) 3 7558-79-4 Petrovsky D and Kramer B 1938 D in experimental lead poisoning rat Proc Soc Exper Biol Med. 38: 435 disodium phosphate, zinc Action de quelques composes phosphide, sodium inorganiques du phosphore sur hypophosphite, calcium l'evolution du rachtisme experimental hypophosphite 3 7558-79-4 Lecoq R and Villius F 1932 du rat rat CR Soc Biol. 109:630-631

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Maximizing calcium and phosphate Bouchoud L, Fonzo- content in neonatal parenteral disodium Christie C, Sadeghipour F nutrition solutions using organic Journal of Parenteral and Enteral Nutrition. hydrogenorthophosphate 3 7558-79-4 & Bonnabry P 2010 calcium and phosphate salts n/a 34(5): 542-545

sodium d-fructose-1,6-diphosphate vs. sodium monohydrogenphosphate in total parenteral nutrition: a disodium comparative in vitro assessment of Journal of parenteral and Enteral Nutrition. hydrogenorthophosphate 3 7558-79-4 Prinzivalli M & Ceccarelli S 1999 calcium/phosphate compatibility n/a 23(6): 235-242

An acute intake of phosphate Disodium increases parathyroid hormone hydrogenorthophosphate Karkkainen M & Lamberg- secretion and inhibits bone formation Journal of bone and mineral research. 11(12): (Na2HPO4) 3 7558-79-4 Allardt C 1996 in young women Man 1905-1912

The effect of high ortho-phosphate water levels on growth, feed intake, nutrient utilization and health status Van Bussel CGJ, ofjuvenile turbot (Psetta maxima) disodium hydrogen Mahlmann L, Kroeckel S, reared in intensive recirculating phsphate 3 Schroeder JP & Schulz C 2013 aquaculture systems (RAS) fish Aquacultural Engineering Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commision related to treatment of poultry carcasses with chlorine dioxide, acidified sodium chlorite, trisodium phosphate and trisodium phosphate (TSP) 4 7601-54-9 EFSA 2005 peroxyacids N/A The EFSA Journal 297.1-28 Assesment of the possible effect of the four antimicrobial treatment substances on the emergence of trisodium phosphate (TSP) 4 7601-54-9 EFSA 2008 antimicrobial resistance N/A EFSA: Summary of opinion

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Opinion onf the Scientific Committee on veterinary measures relating to public health: the evaluation of antimicrobial treatments for poultry trisodium phosphate (TSP) 4 7601-54-9 European Commission 2003 carcasses N/A European Commission Environmental impact and effect on antimicrobial resistance of four Scientific Committee on substances used for the removal of Health and Environmental microbial surface contamination of trisodium phosphate (TSP) 4 7601-54-9 Risks (SCHER) 2008 poultry carcasses N/A European Commission Unknown author where applicable, Workplace environmental exposure mouse, rabbit, American Industrial Hygiene Association trisodium phosphate (TSP) 4 7601-54-9 1982 level guide: trisodium phosphate. rat Journal . 43():b51-b52

Can chemicals precipitate dermatitis trisodium phosphate (TSP) 4 7601-54-9 Snider 1993 herpetiformis human J Am Aced Dermatol 28(1): 111-112

Acute toxicity of inorganic fertilizers Aquaculture and Fisheries Management, 21: trisodium phosphate (TSP) 4 7601-54-9 Ufodike EBC et al 1990 to African catfish Clarias gariepinus catfish 181-185 Induction of mutation with Na3PO4 trisodium phosphate (TSP) 4 7601-54-9 Fraile A and Sang H 1950 and with Harmine Drosphilia Drosophilia Information Service. 24: 81. Reversion of bioluminescent bacteria (Mutatox) to their luminescent state upon exposure to organic compounds, munitions, and Biomedical and environmental sciences, 7: trisodium phosphate (TSP) 4 7601-54-9 Arfsten et al 1994 metal salts bacteria 144-149 effect of sodium hydroxide and trisodium phosphate on the viability mycobacteria trisodium phosphate (TSP) 4 7601-54-9 Bates J.H. 1967 of some unclassified mycobacteria tuberculosis health lab Sci 4(1):42-50 Buzzati-Traverso A Sull'effectto mutageno del fosfato di Ricerca Scientifica E Ricostruzione.17(9-10): trisodium phosphate (TSP) 4 7601-54-9 1947 sodio. ? 1383-1384 Influence of strain and trisodium Capita R, Alonso-Calleja C, phosphate concentration on growth Garcia-Fernandez MC and parameters of Listeria Bacteria: trisodium phosphate (TSP) 4 7601-54-9 Moreno B 2001 monocytogenes in vitro Listeria Letters in Applied Microbiology. 32: 428-432

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Activity of trisodium phosphate compared with sodium hydroxide Capita R, Alonso-Calleja C, was solutions against Listeria Garcia-Fernandez MC and monocytogenes attached to chicken Bacteria: trisodium phosphate (TSP) 4 7601-54-9 Moreno B 2002 skin during refrigerated storage Listeria Food Microbiology . 19: 57-63 Capita R, Alsonso-Calleja Influence of Poultry Carcass Skin C, Rodriguez-Perez R, Sample site on the effectiveness of Moreno B and Garcia- trisodium phosphate against Listeria Listeria trisodium phosphate (TSP) 4 7601-54-9 Fernandez MC 2002 monocytogenes monoctogenes Journal of Food Protection. 65(5): 853-856

Capita R, Alsonso-Calleja C, Sierra Castrillo M, Garcia Arias MT, Moreno B Sensitivity of Listeria monocytogenes Listeria trisodium phosphate (TSP) 4 7601-54-9 and Garcia-Fernandez MC 2000 to trisodium fosfate in vitro monoctogenes Mapfre Medicina. 11(4): 264-273 Some of the higher hydrates of trisodium phosphate Na3PO4 and trisodium phosphate (TSP) 4 7601-54-9 Clark GL and Gross ST 1937 trisodium vanadate Na3VO4 N/A Z. Krist. 98:107-111 Comparison of pathogenic and spoilage bacterial levels on Del Rio E, Capita R, Prieto refrigerated poultry parts following trisodium phosphate (TSP) 4 7601-54-9 M & Alonso-Calleja C 2006 treatment with trisodium phosphate Bacteria food Microbiology. 23: 195-198 Antimicrobial effects of trisodium Dickson JS, Nettles Cutter phosphate against bacteria attached trisodium phosphate (TSP) 4 7601-54-9 CG, Siragusa GR 1994 to beef tissue Bacteria Journal of Food Protection. 57(11): 952-955 Efficacy of chemical treatments against murine norovirus, feline trisodium phosphate (TSP) 4 7601-54-9 D'Souza DH & Su X ? calicivirus, and MS2 bacteriophage Viruses Foodborne pathogens and Disease. 1-7 Ingerson E. and Morey preparation and properties of some G.W. compounds in the system H2O- trisodium phosphate (TSP) 4 7601-54-9 1943 Na2O-P2O5 N/A Amer. Min. 28:448-455

Kim JW, Slavik MF, Pharr Reduction of Salmonella on post-chill MD, Raben DP, Lobsinger chicken carcasses by trisodium trisodium phosphate (TSP) 4 7601-54-9 CM and Tsai S 1993 phosphate (Na3PO4) treatment Salmonella Journal of food safety. 14(1): 9-17

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Effect of trisodium phosphate on Listeria monocytogenes attached to rainbow trout (oncorhynchus mykiss) Mu D, Huang Y, Gates KW and shrimp (Penaeus SPP) during Bacteria: trisodium phosphate (TSP) 4 7601-54-9 and Wu W 1997 refrigerated storage Listeria Journal of Food Safety. 17(1): 37-46 Muus J Die H.ydrolysegeschwindigheit von trisodium phosphate (TSP) 4 7601-54-9 1932 Pyrolrhosphorsânre. n/a Physik Chem A, 159, 268-276

The effects of EDTA and trisodium phosphate, alone and in combination with nisin, on the growth of trisodium phosphate (TSP) 4 7601-54-9 Phillips CA & Duggan J 2001 Arcobacter butzleri in culture Bacteria Food Microbiology. 18:547-554 Slanvin MF, Kim J, Pharr Effect of trisodium phosphate on MD, Raben DP, Tsai S & Campylobacter attached to post-chill trisodium phosphate (TSP) 4 7601-54-9 Lobsinger CM 1994 chicken carcasses Bacteria Journal of Food Protection. 57(4): 324-326 Effect of trisodium phosphate on biofilm and planktonic cells of Campylobacter jejuni, Escherichia coli O157: H7, Listeria Somers EB, Schoeni JL, monocytogenes and Salmonella Bacteria: International Journal of Food Microbiology. 22: trisodium phosphate (TSP) 4 7601-54-9 Wong ACL 1994 typhimurium various 269-276 The system sodium oxide - trisodium phosphate (TSP) 4 7601-54-9 Wendrow B & Kobe KA 1952 phosphorus pentoxide - water n/a Ind Eng Chem. 4: 1439-1448 Effects of trisodium phosphate adaptation on changes in membrane lipid composition, verotoxin secretion, and acid resistance of Escherichia coli O157:H7 in International Journal of Food Microbiology. trisodium phosphate (TSP) 4 7601-54-9 Yuk H, Marshall DL 2006 simulated gastric fluid Bacteria 106: 39-44 Effectiveness of trisodium phosphate for killing Salmonella montevideo on Bacteria: trisodium phosphate (TSP) 4 7601-54-9 Zhuang RY & Beuchat LR 1996 tomatoes Salmonella Letters in Applied Microbiology. 22: 97-100

Czuba M, Zajic A, Effects of sodium phosphate loading Poprzecki S, Cholwea J, on aerobic power and capacity in off Trisodium phosphate 4 7601-54-9 Woska S 2009 road cyclists. human Journal of Sports Science and Medicine

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Disodium phosphate- dihydrate Russell RGG, Edwards NA, Urinary pyrophosphate and (Na2HPO4.2H2O) 4 10028-24-7 Hodgkinson A 1964 urolithiasis Man The Lancet. 27 June: 1446 sodium phosphate loading improves Folland P, Stern R, Brickley laboratory cycling time trial Journal of Science and Medicine in Sport trisodium phosphate 4 G 2008 performance in trained cyclists human (2008) 11, 464-468

Kreider RB, Miler GW, Effects of phosphate loading on Williams MH, Somma CT, oxygen uptake, ventilatory anaerobic Medicine and Science in Sports and Exercise. trisodium phosphate 4 Nasser TA 1990 threshold and run performance humans 22(2): 250-256 Initial submission: Primary skin irritation of sodium sodium acid Bullock CH and Kamienski hexametaphosphate, powdered, in Stauffer Western RC NTIS OTS0555931 (T- pyrophosphate (SAPP) 5 7758-16-9 FX 1972 rabbits Rabbits 1861) Craig JM Histologic and histochemical changes in the kidneys of rats fed a sodium acid diet with an excess of inorganic pyrophosphate (SAPP) 5 7758-16-9 1957 phosphate. rat Am J Pathol. 33: Separate and joint toxicity to rainbow sodium acid Sprague J.B. And Logan trout of substances used in drilling pyrophosphate (SAPP) 5 7758-16-9 W.J. 1979 fluids for oil exploration fish Environ. Pollut 79 :269-280 ABSTRACT: In vivo mutagenesis sodium acid investigations of four GRAS pyrophosphate (SAPP) 5 7758-16-9 Jorgenson T.A. Et al 1978 chemicals Rats Mutation research, 53: 205 Gao RC et al Purification and characterization of sodium acid pyrophosphatase from bighead carp pyrophosphate (SAPP) 5 7758-16-9 2006 (Aristichthys nobilis). Fish LWT 41: 254-261 sodium acid Lambert S M, Watters J I The complexes of pyrophosphate ion pyrophosphate (SAPP) 5 7758-16-9 1957 with alkali metal ions. N/A J Am Chem Soc 79: 4262 - 4265. Inhibition of Clostridium botulinum 52A Toxicity and Protease Activity by sodium acid Wagner M.K. And Busta Sodium Acid Pyrophosphate in applied and environmental microbiology July: pyrophosphate (SAPP) 5 7758-16-9 F.F. 1985 Media Systems bacteria 16-20

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Zhu MJ et al Effect of Maternal Nutrient Restriction sodium acid in Sheep on the Development of pyrophosphate (SAPP) 5 7758-16-9 2004 Fetal Skeletal Muscle. Sheep SODIUM ACID Teratologic evaluation of FDA 71-61, PYROPHOSPHATE 5 7758-16-9 Morgareidge K 1973 (sodium acid pyrophosphate) rats/mice NTIS PB22381 Effects of Selected Commercial Marcy JA, Kraft AA, Phosphate Products on the Natural Hotchkiss DK, Molins RA, Bacterial Flora of a Cooked Meat Olson DG, Walker HW and System JOURNAL OF FOOD SCIENCE. 53(2): 391- trisodium pyrophosphate 6 14691-80-6 Merkenich K 1988 bacteria 393 Trisodium monohydrogen Trisodium monohydrogen pyrophosphate 6 14691-80-6 Hubbard FE 1949 pyrophosphate and its hydrates N/A Ind Eng Chem 41(12): 2908-2911 Teratologic evaluation of FDA 73-1 Tetrasoidum tetrasodium pyrophosphate, NTIS PB245534: Report No: FDABF-GRAS- pyrophosphate (TSPP) 7 7722-88-5 Bailey DE 1976 anhydrous in mice and rats. mice, Rats 353

Mutagenic evaluation of compound. S. typhimuium, Tetrasoidum FDA 73-1, tetrasodium Saccharomyces pyrophosphate (TSPP) 7 7722-88-5 Brusick D 1975 pyrophosphate cerevisiae Litton Bionetics Inc. NTIS PB245489 Effects of added organic residues and calcium carbonate on Tetrasoidum Mnkeni P.N.S. And polyphosphate hydrolysis in four pyrophosphate (TSPP) 7 7722-88-5 MacKenzie A.F. 1987 Quebec soils soil Plant and soil 104: 163-167 Metal Ions Reverse the Inhibitory Effects of Selected Food-Grade Lee RM, Bartami PA, Olson Phosphates in Staphylococcus Journal of Food Protection. Vol. 57. No. 4. tetrasodium pyrophosphate 7 7722-88-5 DG & Wiliams FD 1994 aureus Bacteria Pages 284·288. Bidwell J.I., Jepson W.B. The interaction of kaolinite with and Toms G.L. polyphosphate and polyacrylate in Tetrasoidum aqueous solutions - some preliminary pyrophosphate (TSPP) 7 7722-88-5 1970 results. N/A Clay Minerals. 8: 445-459 Tetrasoidum Bonneman-Bémia P. Contribution a l'étude des acides pyrophosphate (TSPP) 7 7722-88-5 1941 phosphoriques condensés. N/A Ann. Chim. 16:395-477 The crystal structure of sodium tetrasodium pyrophosphate MacArthur DM and Beevers pyrophosphate decahydrate, (decahydrate) 7 7758-16-9 CA 1957 Na4P2O7.10H2O N/A Acta Cryst. 10, 428-432

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested tetrasodium pyrophosphate Rao RVGS and Unit cell and space group of sodium (decahydrate) 7 7758-16-9 Nampoothiri NS 1955 pyrophosphate N/A Acta cryst. 8:850

Tetrasoidum Biochemical studies in effects of Journal of Biological Chemistry: 242(10): 2375- pyrophosphate (TSPP) 7 7722-88-5 Tono H and Kornberg A 1967 phosphates in bacterial sporulation. Bacteria 2382 Acute oral or dermal and repeated dose 90-day oral toxicity of Seo DS, Kwon M, Jung tetrasodium pyrophosphate in Environmental Health and Toxicology. 26. tetrasodium pyrophosphate 7 7722-88-5 Sung H, Park CB 2011 Sprague Dawley (SD) rats Rat Article ID: e2011014: 9 pages Letter. Mutagenicity of octane and tetrasodium pyrophosphate in Kim SJ, Rim KT, Kim HY & bacterial reverse mutation (Ames) The Journal of Toxicological Sciences. 35(4): tetrasodium pyrophosphate 7 7722-88-5 Yang JS 2010 test bacteria 555-562 Soft-tissue calcification induced by tetrasodium pyrophosphate Gabbiani G, JacQmin ML & rare earth metals and its prevention (decahydrate) 7 7722-88-5 Richard RM 1966 by sodium pyrophosphate rat Br. J. Pharmac. Chemother. 27:1-9

Inhibition by pyrophosphate and Tetrasodium Schibler D, Russel RGG & polyphosphate of aoritc calcification pyrophosphate 7 7722-88-5 Fleisch H 1968 induced by Vitamin D3 in rats Rat Clin Sci. 35: 363-372 The effect of sodium trimetaphosphate as a chewing gum sodium trimetaphosphate additive on caries increment in (STMP) 8 7785-84-4 Finn SB et al 1978 children human j am den assoc 96: 651-655 Longitudinal Study of Cariostatic Effects of Sodium Trimetaphosphate and Sodium Fluoride When Fed sodium trimetaphosphate Separately and Together in Diets of (STMP) 8 7785-84-4 Navia J.M. And Harris R.S. 1969 Rats Rats J. Dent. Res. 48(2): 183-191 Cariostatic effects of sodium trimetaphosphate when fed to rats sodium trimetaphosphate Navia J.M., Lopez H. And during different stages of tooth (STMP) 8 7785-84-4 Harris R.S. 1968 development Rats Archs oral Biol 13: 779-786 Initial submission: Primary skin irritation of sodium sodium trimetaphosphate Bullock CH and Kamienski hexametaphosphate, powdered, in Stauffer Western RC NTIS OTS0555931 (T- (STMP) 8 7785-84-4 FX 1972 rabbits Rabbits 1861)

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested sodium trimetaphosphate Busman L.M. And Hydrolysis of trimetaphosphate in (STMP) 8 7785-84-4 Tabatabai M.A. 1985 soils soils soil sci soc amer proc 49: 630-636 sodium trimetaphosphate Katchman BJ and Smith Diffusion of synthetic and natural Archives of Biochemistry and Biophysics. 75: (STMP) 8 7785-84-4 HE 1958 polyphosphates. n/a 396-402. sodium trimetaphosphate Lieberman I Inorganic triphosphate synthesis by (STMP) 8 7785-84-4 1956 muscle adenylate kinase. n/a J biol chem. 219: 307-317 sodium hexametaphosphate 9 68915-31-1 Abelles. N 1927 toxicity of the (see substance) rats Biochem Z., 163():226

Further observations on the effects of polysodium the oral administration of polysodium metaphosphate PSMP 9 10124-56-8 Anderson C.K. Et al 1961 metaphosphate in the rat Rats Br. J. urol. 33: 135-140 Long-chain polyphosphates inhibit sodium polyphosphate growth of clostridium tyrobutyricum mixture (SPG 69%) 9 68915-31-1 Loessner M.J. Et al 1997 in processed cheese spreads bacteria J. Food protection 60(5): 493-498 Treatment of experimental acute uranium poisoning by chelating sodium polyphosphate 9 68915-31-1 Ortega A. et al 1989 agents mice Pharmacology and toxicology 64: 247-251 Long-chain polyphosphate causes cell lysis and inhibits Bacillus cereus Maier SK, Scherer S and spetum formation, which is Bacteria: Applied and environemtal microbiology. 65(9): sodium polyphosphate 9 68915-31-1 Loessner MJ 1999 dependant on divalent cations. Bacillus cereus 3942-3949 Growth Inhibition of Listeria monocytogenes by Sodium Zaika LL, Scullen J and Polyphosphate as Affected by sodium polyphosphate 9 68915-31-1 Fanelli JS 1997 Polyvalent Metal Ions bacteria Journal of food science 62(4): 867-870 sodium Teratologic evaluation of FDA 73-3 hexametaphosphate sodium hexametaphosphate in mice NTIS PB245535: Report No: FDABF-GRAS- (SHMP) 10 10124-56-8 Bailey DE 1974 and rats. mice, Rats 354 sodium Mutagenic evaluation of compound. S. typhimuium, hexametaphosphate FDA 73-3, Sodium Saccharomyces (SHMP) 10 10124-56-8 Brusick D 1975 hexametaphosphate cerevisiae Litton Bionetics Inc. NTIS PB245486 Initial submission: Primary skin sodium irritation of sodium hexametaphosphate Bullock CH and Kamienski hexametaphosphate, powdered, in Stauffer Western RC NTIS OTS0555931 (T- (SHMP) 10 10124-56-8 FX 1972 rabbits Rabbits 1861)

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Kitahori Y, Konishi N, Cho sodium M, Yamamoto K, hexametaphosphate Nakagawa Y, Matsui E and Lack of carcinogenicity of sodium (SHMP) 10 10124-56-8 Hiasa Y 1998 metaphosphate in Fischer 344 rats. rat J Toxicol Pathol. 11:41-47 sodium Influence of sodium hexametaphosphate hexametaphosphate on selected (SHMP) 10 10124-56-8 Post F.J et al 1963 bacteria bacteria appl. Microbiology 11(5): 430-435 Influence of Hexametaphosphate on sodium Matsuoka A, Tsutsumi M & Staphylococcus aureus Cytoplasmic hexametaphosphate 10 10125-56-8 Wantanbe T 1997 Membrane Bacteria J. Food Hyg. Soc. Japan. 38(6): 441-445 Inhibitory Effect of sodium Matsuoka A, Tsutsumi M & Hexametaphosphate on the Growth hexametaphosphate 10 10125-56-8 Wantanbe T 1995 of Staphylococcus aureus Bacteria J. Food Hyg. Soc. Japan. 36(5): 588-594 sodium hexametaphosphate Physical properties of sodium (SHMP) 10 10124-56-8 Thomson RT 1935 hexametaphosphate. n/a Analyst, 61:320-323 sodium Baluyot E S., and Hartford Comparsion of polyphosphates hexametaphosphate C U analysis by ion chromatography and (SHMP) 10 10124-56-8 1996 modified end-griup titration n/a Journal of chromatography A.739.717-222. sodium The preparation and properties of hexametaphosphate tetra-, penta-, hexa-, hepta- and Journal of the American chemical society. (SHMP) 10 10124-56-8 Griffith EJ 1967 octaphosphates. 89(12): 2884 – 2890 sodium K. K. Jones hexametaphosphate The Physiology of Sodium American Water Works Association, p1471- (SHMP) 10 10124-56-8 1940 Hexametaphosphate. ? 1483 Stover FS et al Polyphosphate separations and chain sodium length characterization using hexametaphosphate minibore ion chromatography with (SHMP) 10 10124-56-8 1994 conductivity detection. n/a Journal of Chromatography A, 688: 89-95 Repressible acid phosphomonoesterase and sodium consitutive pyrophosphatase of hexametaphosphate 10 10124-56-8 Weimberg R & Orton W L 1963 saccharomyces mellis n/a J. Bacteriol. 86:805-813

The mechanism of the hydrolysis of condensed phosphates. II. The sodium metaphosphate Watanabe M, Sato S and mechanism of the degradation of Bulletin of the Chemical Society of Japan insoluble (IMP) 11 10361-03-2 Saito H 1975 long-chain polyphosphates N/A 48(3): 896-898

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested sodium metaphosphate MZUZA8 Meditsinskii. Zhurnal MZUZA8 Meditsinskii. Zhurnal Uzbekistana. 8: insoluble (IMP) 11 10361-03-2 Axmedkahob D.K.A and Xalnaev1973 O.S.Uzbekistana. 8: 90 - 93 ? 90 - 93 Initial submission: Primary skin irritation of sodium sodium metaphosphate Bullock CH and Kamienski hexametaphosphate, powdered, in Stauffer Western RC NTIS OTS0555931 (T- insoluble (IMP) 11 10361-03-2 FX 1972 rabbits Rabbits 1861)

Bone formation in normal and sodium metaphosphate vitamin D-treated rachitie rats during insoluble (IMP) 11 10361-03-2 Irving J.T., Schibler D., and Fleisch1966 H.the administration of polyphosphates. rat Proc. Soc. Exp. Biol. Med. 123:332-335 Katchman BJ and Van sodium metaphosphate Wazar JR The "soluble" and "insoluble" insoluble (IMP) 11 10361-03-2 1954 polyphosphates of yeast. yeast Biochi biophys Acta. 14: 445-446 On the occurance of inorganic sodium metaphosphate polyphosphate hexokinase in some insoluble (IMP) 11 10361-03-2 Szymona M, Szymona O and1962 Kuleszamicroorganisms. S n/a Acta Microbiologica Polonica. 11:287-300 Structure and properties of the condensed phosphates. IV. Complex sodium metaphosphate Van Wazer J R, ion formation in polyphosphate insoluble (IMP) 11 10361-03-2 Campanella D A 1950 solutions. N/A J Amer. Chem. Soc. 72: 655 - 663

Inhibition of skin calcification Cellular and molecular life sciences. 22(6): 367- Grahams salt 11 10361-03-2 Schibler D & Fleisch H 1966 () by polyphosphates Rat 369 availability of phosphorus compounds as dietary phosphorus potassium sources for red sea bream dihydrogenorthophosphate 12 7778-77-0 Sakamoto S. amd Yone Y. 1979 (chrysophrys major) fish J. Fac. Agr. Kyushu Univ. 23, 177-184 Teratologic evaluation of FDA 73-65 monopotassium phosphate monopotassium phosphate in mice NTIS PB245521: Report No: FDABF-GRAS- (MKP) 12 7778-77-0 Bailey DE 1975 and rats. mice, Rats 340 NTIS Initial Submission: Toxicology Lab Report T-1680 Regarding Toxicity Studies Including Tripotassium Phosphate and Other Chemicals with Cover Letter Dated monopotassium phosphate 102729 Monopotassium Phosphate Stauffer Chemical Company, Western (MKP) 12 7778-77-0 Kamienski FX 1971 Acute Oral Screen Male Rats Research

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Mutagenic evaluation of compound. S. typhimuium, monopotassium phosphate FDA 73-65, monopotassium Saccharomyces (MKP) 12 7778-77-0 Brusick D 1975 phosphate granular food grade cerevisiae Litton Bionetics Inc. NTIS PB245513 Molluscicidal activity of potassium to the zebra mussel, Dreissena monopotassium phosphate polymorphia; toxicity and mode of (MKP) 12 7778-77-0 Fischer W et al 1991 action Mussel Aquatic toxicology 20(4): 219-234 Dietary phosphorus requirements of Brown ML Jaramilloe F Jnr, juvienille sunshine bass, Morone monopotassium phosphate 12 7778-77-0 Gatlin DM III 1993 chrysops ♀ X M. saxatilis ♂ fish Aquaculture, 113 (1993) 355-363 Dougall DS, Curry Woods Dietary Phosphorus Requirement of L III, Douglass LW & Juvenile Striped Bass Morone The Journal of the world aquaculture society. monopotassium phosphate 12 7778-77-0 Soares JH 1996 saxatillis fish 27(1): 82-92 Béranger-Yvon A.et al. Quelques aspects de l'action des acides orthophorique, pyrophosphorique et adénosine- triphosphorique sur la croissance et monopotassium phosphate la photosynthèse de chlorella Revue de Cytologie et de Biologie Végétales. (MKP) 12 7778-77-0 1958 pyrenoidosa chick. algae XIX,2:433-452

Evidence that glucose is not always potassium dihydrogen Biggers JD and McGinnis an inhibitor of mouse preimplantation phosphate 12 7778-77-0 LK 2001 development in vitro mouse Human Reproduction. 16(1): 153-163 monopotassium phosphate X-ray analysis of the ferroelectric (MKP) 12 7778-77-0 Frazer BC and Pepinsky R 1953 transition in KH2PO4 N/A Acta Cryst. 6:273 Harris W W, et al. monopotassium phosphate Stimulation of Bone Formation in (MKP) 12 7778-77-0 1976 vivo by Phosphate Supplementation, dogs Calcif., Tiss. Res., 22, 85-98. Petters RM. et al. Glucose, glutamine and inorganic monopotassium phosphate phosphate in early development of Journal of Reproduction and Fertility. 89:269- (MKP) 12 7778-77-0 1990 the pig embryo in vitro. pig 275 Dipotassium phosphate (DKP) 12 7778-77-0 Rana 1974 Ecophysiological studies on the uptakealgae of the pollutants, Indian copper, J Ecol zinc 1(1):and phosphate1-11 by certain algae Structure andthermal properties associated with some hydrogen monopotassium phosphate Ubbelohde AR & bonds in crystals. VII. Behaviour of Proceedings of the Royal Society 188 S: 358- (MKP) 12 7778-77-0 Woodward I 1947 KH2PO4 and KH2AsO4 on cooling n/a 372

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XXVI. A quantitative X-ray analysis of monopotassium phosphate the structure of potassium (MKP) 12 7778-77-0 West J 1930 dihydrogen phosphate (KH2PO4) n/a Zeitschrift Fur Kristallographie. 74:306-332

Naddy RB, Tapp K, Identifying the cause of toxicity in an Rehner AB, Pillard DA, algal whole effluent toxicity study – monopotassium phosphate 12 7778-77-0 Schrage L 2011 An unanticipated toxicant algae Chemosphere 85 (2011) 1026–1032 Sex differences in mineral Matsuzaki H, Katsumata S, concentrations and urinary albumin potassium Uehara M, Uehara M, excretion in rats given high- dihydrogenorthophosphate 12 7778-77-0 Nakamura K &Suzuki K 2002 phosphorus feed. rat Biosci. Biotechnol. Biochem 66(8): 1737-1739

A comparison of the relative toxicity of bone meal and other P sources potassium used as remedial treatments to the dihydrogenorthophosphate 12 7778-77-0 Atuah L & Hodson ME 2011 earthworm Eisenia fetida earthworm Pedobiologia. Article in press, Remediation of Heavy Metal- Contaminated Soils Using Phosphorus: Evaluation potassium Maenpaa KA, Kukkonen of Bioavailability Using an Earthworm dihydrogenorthophosphate 12 7778-77-0 JVK & Lydy MJ 2002 Bioassay earthworm Arch. Environ. Contam. Toxicol. 43, 389–398 Haematological modulations in male European Rabbit, Orycytolagus cuniculus (LINN.) exposed to potassium Dhembare AJ, Gholap AB potassium dihydrogen dihydrogenorthophosphate 12 7778-77-0 & Khatode R 2011 orthophosphate rabbit J. Exp. Zool. India. 14(2): 523-526 Plasma alkaline phosphatase as a potassium criterion for determining biological dihydrogenorthophosphate 12 7778-77-0 Boyd RD, Hall D & Wu JF 1983 availability of phosphorus for swine. pig Journal of Animal Science. 57(2):396-401

Potassium The relation of the dietary Ca:P ratio dihydrogenorthophosphate to serum Ca and to parathyroid (KH2PO4) 12 7778-77-0 Stoerk HC & Carnes WH 1945 volume Rat J Nutr. 29(1): 34-50

Potassium dihydrogen United States Environmental Protection phosphate 12 7778-77-0 Kumar R 1998 Pesticide fact sheet N/A Agency

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potassium dihydorgenorthophosphate, Anderson MP, Hunt RD, Long-Term Effect of Low Dietary calcium hydrogen Griffiths HJ, Mcintyre KW & Calcium:Phosphate Ratio on the phosphate 12 Zimmerman RE 1977 Skeleton of Cebus albifrons Monkeys monkeys J. Nutr. 107: 834-839 The effects of elevated concentrations of dissolved inorganic phosphate in on the growth potassium dihydrogen and survival of juvenile abalone, phosphate 12 James PJ & Barr NG 2012 Haliotis iris abalone Aquaculture Research, 2012, 43, 438–446

Water-soluble Phosphates: Observed Effects on Embryonic potassium dihydrogen Toor HS, Sehgal HS & Brar Development, Hatching Time, and phosphate 12 CS 1983 Survival of Common Carp fish Prog. Fish-Cult. 45(2): 134-135

Effects of prolonged high phosphorus Tani Y, Sato T, Yamanaka- diet on phosphorus and calcium Journal of Clinical Biochemistry and Nutrition. monopotassium phosphate 12 Okumura H et al 2007 balance in rats rat 40: 221-228 Initial submission: Primary skin irritation of sodium Dipotassium phosphate Bullock CH and Kamienski hexametaphosphate, powdered, in Stauffer Western RC NTIS OTS0555931 (T- (DKP) 13 7758--11-4 FX 1972 rabbits Rabbits 1861) Chu, SP The influence of the mineral composition of the medium on the growth of planktonic algae. Part II: The influence of the concentration of Dipotassium phosphate inorganic nitrogen and phosphate (DKP) 13 7758-11-4 1943 phosphorus. algae Journal of Ecology, 31(2):109-148.

Potassium Hydrogen Phopshate Dipotassium phosphate induced nephropathy in the dog. Part (DKP) 13 77 Schneider P. et al - Part I 1980 I. Pathogenesis of tubular atrophy dog Vet. Pathol. 17: 699-719

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Potassium Hydrogen Phopshate Dipotassium phosphate induced nephropathy in the dog. Part (DKP) 13 7758-11-4 Schneider P. et al - Part II 1980 II. Glomerular alterations dog Vet. Pathol. 17: 720-737 Elam CJ, Schneider BH Experimetally produced urinary dipotassium phosphate 13 7758-11-4 and Ham WE 1956 canuli in sheep Sheep J Anim Sci 1956. 15:800-810. Contribution a l'étude du systéme Dipotassium phosphate Flatt R, Brunisholz G and quinaire. Ca++ - K+-H+-NO3- - PO4-- (DKP) 13 7758-11-4 Bourgeois J 1956 - -H2O N/A Helv Chim Acta. 39:841-53 Dietary calcium and phosphorus Dipotassium phosphate levels and the vitamin D requirement (DKP) 13 7758-11-4 Nowotarski JS and Bird HR 1943 of the Chick chicken Poultry Sci. 22:72-78 Dipotassium phosphate Le system binaire: eau phosphate (DKP) 13 7758-11-4 Selva L 1947 dipotassique n/a Bull. Soc. Chim. France: 261-264 Morishita K, Shirai A, Kubota M, Katakuru Y, The Progression of Aging in Klotho Nabeshima Y, Takeshige K Mutant Mice Can Be Modified by monopotassium phosphate 13 & Kamiya T 2001 Dietary Phosphorus and Zinc mice The Journal of Nutrition. 131:3182-3188 tetrapotassium Pyrophosphate Hydrolysis in soil as pyrophosphate (TKPP) 15 7320-34-5 Racz G.J. And Savant N.K. 1972 influenced by flooding and fixation soil soil sci soc amer proc 36: 678-682

Subchronic oral toxicity study of potassium phosphate as a tetrapotassium preliminary to long-term pyrophosphate (TKPP) 15 7320-34-5 Shimoji N. et al 1988 carcinogenicity studies in F344 rats Rats Bul. Institute Hygenic sciences 106: 66

Potassium pyrophosphate, polyphosphates and The biochemistry of Inorganic cyclophosphates 15 7320-34-5 Kulaev IS 2004 polyphosphates N/A 2nd edition John Wiley and Sons Ltd Vibrational spectra of hydrated acid potassium tripolyphosphate Lyutsko VA, Shashkova IL and intermediate potassium (KTPP) 16 13845-36-8 and Prodan EA 1982 tripolyphosphate N/A Source unknown Masuyama R, Kajita Y, Odachi J, Uehara M, Chronic phosphorus supplementation tetrapotassium Shigematsu T, Suzuki K & decreases the expression of renal triphosphate 16 n/a Goto S 2000 PTH/PTHrP receptor mRNA in rats rat Am J Nephrol. 20:491-495

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Effect of high dietary phosphorus concentration and different dietary potassium tripolyphosphate Matsuzaki H, Ohdachi J, phosphorus forms on bone strength Japanese Journal of Health , Fitness and (KTPP) 16 13845-36-8 Kajita Y & M Miwa 2008 2008 and bone turnover in rats rat Nutrition. 13(2): 10-12 experiments on the metabolic potassium metaphosphate behaviour of highly condensed (KMP) 17 7790-53-6 Gassner K. 1957 potassium metaphosphate Rats biochem Z., 328: 485-491 potassium metaphosphate the hydrolysis of condensated (KMP) 17 7790-53-6 Thilo E. and Wieker W. 1957 phosphates in aqueous solution water Z anorg allg chem 291: 164-185 monoammonium Brosheer JC and Anderson The system ammonia-phosphoric phosphate (MAP) 18 7722-76-1 JF 1946 acid-water at 75° N/A unknown, 68:902-904 The effects of fire control chemicals Fire retardant (Phos- on hatchability of northern bobwhite Chek)containing quail (Colinus virginianus) and red- Monoammonium winged blackbirds (Agelaius phosphate 18 7722-76-1 Buscemi DM 1998 phoniceus) Birds University of Virginia MS Thesis. The toxicity of banded Urea or Diammonium phosphate to corn as diammonium phosphate influenced by soil temperature, (DAP) 18 7722-76-1 Creamer FL and Fox RH 1980 moisture and pH SOIL Soil Sci Soc Am J. 44(2): 296 The effect upon hematopoeisis of variations in the dietary levels of monoammonium Calcium, Phosphorous, Iron and phosphate (MAP) 18 7722-76-1 Day HG and Stein HJ 1938 Vitamin D: Two figures. Rats The Journal of Nutrition 16(6): 525-540 monoammonium Polosin VA and phosphate (MAP) 18 7722-76-1 Shakhporonov MI 1947 ? N/A Zh Fiz Khim. 21:119-123 monoammonium Acute Ammonium Salt Poisoning in phosphate (MAP) 18 7722-76-1 Singer R.H. and McCarty R.T.1971 Sheep. sheep Am. J. Vet. Res., 32(8): 1229-1238 Biochemical toxicity of fertiliser di- diammonium phosphate ammonium phosphate to fish Clarias (DAP) 18 7722-76-1 Singh R et al 1995 batrachus FISH Uttar Pradesh J Zool. 15(2): 144-148 monoammonium Tenzer L, Frazer BC, A neutral structure analysis of phosphate (MAP) 18 7722-76-1 Pepinsky R 1958 tetragonal NH4H2PO4 N/A Acta Cryst. 11:505

Phosphorus concentrations in blood, Williams SN, McDowell LR, milk, feces, bone and selected fluids Warnick AC, Wilkinson NS and tissues of growing heifers as Livestock Research fro Rural development. monoamminium phosphate 18 and Lawrence LA 1991 affected by dietary phosphorus cows 3(2) [no pg numbers]

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Phosphorus (unspecified), Influence of forest rangeland ammonium phosphate, management on anadromous fish aminomethylphosphonic Norris LA, Lorz HW and habitat in western North America: USDA Forest Service General Technical acid 18 233-330-0 Gregory SV 1983 Forest chemicals Report PSW-149 Influences of Forest and Rangeland Ammonium phosphate, Managentent on Salmonid Fishes American Fisheries Society Special Publication diammonium phosphate 18 7722-76-1 Meehan WR 1991 and Their Habitats fish 19 Report: Missoula Technology and Ammonium phosphate, Ecological risk assessment: wildland Development Center, USDA Forest Service, diammonium phosphate 18 7722-76-1 Modovsky C 2007 fire-fighting chemicals enviroment Missoula, MT ammonium phosphate Crawford JD, Osborne MM, (rat), phosphorus solutions Talbot NB, Terry ML & The parathyroid gland and (unspecifed, human) 18 7722-76-1 Morrill MF 1950 phosphorus homeostasis rat, man [source unknown] 1448-1461 Toxicity of forest fire retardant dietrich JP, Myers M, chemicals to stream-type chinook Strickland SA, Gaest AV & salmon undergoing parr-smolt Environmental Toxicology and Chemistry Phos-chekdiammonium (DAP phosphate + 18 7722-76-1 Arkoosh MR 2012 transformation fish DOI 10.1002/etc.2052 additives) Fire-Trol 931 Handbook of Acute Toxicity of United States Department of the Interior Fish (ammonium polyphosphate Johnson WW and Finley Chemicals to Fish and Aquatic Fish and and Wildlife Service / Resource publication + additives) 19 7783-28-0 MT 1980 Invertebrates. invertebrates 137.

Palanichamcy S., Food consumption of Sarotherodon Arunachamy S and Mossambicus (Trewaves) exposed to diammonium phosphate Balasubramanian M P sublethal concentration of (DAP) 19 7783-28-0 1985 diammonium phosphate fish ? Toxicty of Diammonium Phosphate diammonium phosphate Singh HR, Anoop K, to the Hillstream Minor Carp Barilus (DAP) 19 7783-28-0 Dobriyal and Pokhriyal RC 1985 Bendelisis Fish Uttar Pradesh J Zool, 5(1): 89-93

Crystallographic properties of diammonium phosphate Smith JP, Lehr JR and diammonium phosphate, (DAP) 19 7783-28-0 Brown WE 1957 (NH4)2HPO4 N/A Acta Cryst. 10: 709

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Stavanja MS, Curtin GM, Ayres PH, Bombick ER, Borgerding MF, Morgan WT, Garner CD, Pence DH and Swauger JE Safety assessment of diammonium diammonium phosphate phosphate and urea used in the Experimental and Toxicologic Pathology 59: (DAP) 19 7783-28-0 2008 manufacture of cigarettes. CHO cells 339-353. Lobster larvae diammonium phosphate Marine bioassays with lobster larvae and (DAP) 19 7783-38-0 Wood 1985 and gammarids Gammarids Can Tech Rep Fish Aquat Sci, 0: 351-372 Effect of DAP toxicity on diammonium phosphate haematology of catfish (DAP) 19 7783-28-0 Yadav HN and Akela BP 1997 Heteropneustes fossilis (Bloch). Fish Environment and Ecology 15(2): 455-459 Effect of DAP toxicity on certain diammonium phosphate Yadav HN, Akela BP and haematological parameters of (DAP) 19 7783-28-0 Kumari A 1998 Heteropneustes fossilis (Bloch). Fish Environment and Ecology 16(2): 431-434 diammonium phosphate Oltjen RR, Waller GR, Ruminant studies with diammonium (DAP) 19 7783-28-0 Nelson AB and Tillman AD 1963 phosphate and urea Sheep J. Anim. Sci. 24:36-42

Adaptation to and platability of urea, diammonium phosphate Schaadt H, Johnson RR biuret and diammonium phosphate (DAP) 19 7783-28-0 and McClure KE 1966 as NPN sources for ruminants Sheep J. Anim. Sci. 23: 73-77 In vitro and in vivo comparisons of diammonium phosphate Johnson RR and McClure the utilization of urea, biuret and (DAP) 19 7783-28-0 KE 1964 diammonium phosphate by sheep. Sheep J. Anim. Sci. 23: 208-213 Evaluation of diammonium diammonium phosphate Russel EL, Hale WH and phosphate as a source of nitrogen for (DAP) 19 7783-28-0 Hubbert F 1962 ruminants Sheep J. Anim. Sci. 21: 523-226 diammonium phosphate as a source diammonium phosphate Cowman GL and Thomas of nitrogen and phosphorous for beef (DAP) 19 7783-28-0 O 1962 cattle Cows J. Anim. Sci. 21: 992 An evaluation of diammonium Lassiter CA, Brown LD and phosphate as a nitrogen source for diammonium phosphate 19 Keyser D 1962 ruminants cows Mich State University Quartly Bulletin.

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Evaluation of the adverse effects of two commonly used fertilizers, DAP Azizullah A, Nasir A, and urea, Richter P, Lebert M & on motility and orientation of the Environmental and Experimental Botany 74: diammonium phosphate 19 7783-28-0 Hader DP 2010 green flagellate Euglena gracilis Euglena gracilis 140– 150 Food consumption of Sarotherodon Palanichamcy S., mossambicus (Trewaves) exposed to Sarotherodon Arunachamy S and sublethal concentration of mossambicus Balasubramanian M P diammonium phosphate (Short-term Diammonium phosphate 19 7783-28-0 toxicity to fish - OECD 203) Hydrobiologia 128:233-237 ammonium Effect of anti-flame treating agents polyphosphates 20 14728-39-3 Aoyama M. 1975 Ammoniumon the skin Polyphosphate as a rats and rabbits Nagoya Med, 20(1): 11-19 Ammonium polyphosphate source of nitrogen and phosphorous Agricultural experimental station bulletin 497: 1- (APP) 20 68333-79-9 Bell et al 1986 in cattle rations catlle 15

Hydrolysis of Pyrophosphate in a Highly Calcareous Soil: A Solid-State ammonium polyphosphate 20 14728-39-3 McBeath et al 2006 Phosphorus-31 NMR Study soil soil sci soc amer proc, on line march 29

Ammonium polyphosphate Liquid ammonium polyphosphate as Transactions of the American Fisheries (APP) 20 68333-79-9 Metzger RJ 1980 a fish pond fertilizer FISH Society, 109: 563-570 Liquid ammonium Liquid ammonium polyphosphate as Transactions of the American Fisheries polyphosphate (APP) 20 68333-79-9 Metzger RJ and Boyd CE 1980 a fish pond fertiliser. Fish society. 109:563-570 Liquid ammonium Liquid ammonium polyphosphate as fish and Transactions of the American Fisheries polyphosphate 20 68333-79-9 Metzger RJ and Boyd CE 1980 a fish pond fertiliser. plankton society. 109:563-570 ammonium polyphosphate, reactions of ammonium ortho- and triammonium polyphosphate fertilizer in soil: III pyrophosphate 20 14728-39-3 Sample E.C. Et al 1979 effects of associated cations soil soil sci soc amer 43: 58-65 Hydrolysis of ammonium Venugopalan M.V. And polyphosphate in soils under aerobic ammonium polyphosphate 20 14728-39-3 Prasad R. 1989 and anaerobic conditions soils biol fertil soils 8: 325-327 Initial Submission: acute toxicity test battery for monocalcium phosphate monocalcium phosphate anhydrous with cover letter dated (MCP) 21 7758-23-8 Sorenson SS 1985 102392 Rat NTIS OTS0571950 Report No. T-12163 Initial Submission: acute toxicity test battery for monocalcium phosphate monocalcium phosphate anhydrous with cover letter dated (MCP) 21 7758-23-8 Sorenson SS 1985 102392 Rabbit NTIS OTS0571950 Report No. T-12163

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Initial Submission: acute toxicity test battery for monocalcium phosphate monocalcium phosphate anhydrous with cover letter dated (MCP) 21 7758-23-8 Sorenson SS 1985 102392 Rabbit NTIS OTS0571950 Report No. T-12163 Initial Submission: acute toxicity test battery for monocalcium phosphate monocalcium phosphate anhydrous with cover letter dated (MCP) 21 7758-23-8 Sorenson SS 1985 102392 Rabbit NTIS OTS0571950 Report No. T-12163

S. typhimuium, monocalcium phosphate Mutagenic evaluation of compound. Saccharomyces (MCP) 21 7758-23-8 Brusick D 1975 FDA 71-81, monocalcium phosphate cerevisiae Litton Bionetics Inc. NTIS PB245509 Hydrolysis of primary calcium monocalcium phosphate phosphate in function of the (MCP) 21 7758-23-8 Guillaume M. 1963 temperature water Bull. Sco. Roy. Sci. Liege 32(5-6): 362-365 monocalcium phosphate phosphate induced renal calcification (MCP) 21 7758-23-8 Hitchman A.J. et al 1979 in the rat rats can j physiol pharmac 57(1):92 interaction of monocalcium monocalcium phosphate phosphate monohydrate with water (MCP). 1-hydrate 21 10031-30-8 Misra N.P. Et al 1981 solubility and hydrolysis soil fert news 26: 34-36 monocalcium phosphate the hydrolysis rate of monocalcium (MCP) 21 7758-23-8 Pozin M.E. Et al 1959 phosphate in aqueous solutions water j appl chem ussr 32: 736 monocalcium phosphate Sollmann T. Schettler O.H. studies of chronic toxicity in albino (MCP) 21 7758-23-8 And Wetzel N.C. 1921 rats IV Rats j pharm exp therap 17():197-225

Application of phase rule to the monocalcium phosphate chemical behaviour of monocalcium (MCP) 21 7758-23-8 Brown WE and Lehr JR 1959 phosphate monohydrate in soils. N/A Soil Sci. Soc. Am. Proc. 23:7-11

Nature of reactions of monocalcium monocalcium phosphate Lindsay WL and phosphate monohydrate in soils: I. (MCP) 21 7758-23-8 Stephenson HF 1959 The solution that reacts with the soil. N/A ? Effect of calcium phosphate monocalcium phosphate Jones MR, Hardwick LL, supplementation on blood pressure (MCP) 21 7758-23-8 Clemens RA 1987 in the wistar rat. rat Nutrition Research, 7:779-785 dietary phosphorus requirements of juvienile haddock (Melanogrammus monocalcium phosphate 21 7758-23-8 Roy PK and Lall SP 2003 aeglefinus L.) fish Aquaculture 221 (2003) 451–468

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Control of phosphorus homeostasis monocalcium phosphate. of Atlantic salmon (Salmo salar) in Monohydrate 21 7758-23-8 Vielma J and Lall SP 1998 fresh water. fish Fish Pysiology and biochemistry, 19 :83-93 In Russian, so the GTPZAB (1987) Phosphoric Acid russians :) calcium salt (2:) monohydrate. monocalcium phosphate RTECS Gigiena Truda I Labor Higiene and Occupational Diseases 31 (MCP) 21 7758-23-8 1987 Professional'nye Zabolevniya. N/A (12) 53. Comunicacion Corta Intoxicacian por monocalcium phosphate fosfato dicaclcico (CaHPO4) en (MCP) 21 7758-23-8 Alfonso et al 1988 terneros calf Rev Salud Anim, 10 : 261-262 Mineral metabolism of aging female rats fed various commercially monocalcium phosphate available calcium supplements or (MCP) 21 7758-23-8 Behling et al 1988 yoghurt rats Pharmaceutical Research, 5 (8): 501-505 The vapour pressures of saturation monocalcium phosphate solutions and solubilities in the (MCP) 21 7758-23-8 Belopolski et al 1940 system N/A Unknown monocalcium phosphate Investigations on the solubility of (hydrated and anhydrous), 21 7758-23-8 Bjerrum N 1949 calcium phosphates N/A Niels Bjerrum Selected Papers. 245-249 Calcium phosphate containing monocalcium phosphate precipitate and the carcinogenicity of (MCP) 21 7758-23-8 Cohen S.M. Et al 2000 sodium salts in rats rats Carcinogenesis 21(4): 783-792

monocalcium phosphate (MCP) 21 7758-23-8 Cohen SM 1998 Cell proliferation and carcinogenesis Cells drug metabolism reviews, 30(2): 339-357 monocalcium phosphate Dissolution behaviour of carbonated drug development and industrial pharmacy, (MCP) 21 7758-23-8 Daabees N et al 1988 apatites in the presence of some ions 14(3): 1855-1875 Everson GE et al monocalcium phosphate Chemistry Set Chemicals: An (MCP) 21 7758-23-8 1988 Evaluation of Their Toxic Potential. N/A Vet Hum Toxicol 30(6): 589-592 Fleisch H and Russell RGG A Review of the Physiological and Pharmacological Effects of monocalcium phosphate Pyrophosphate and Diphosphonates (MCP) 21 7758-23-8 1972 on Bones and Teeth. N/A J Dent Res Supplement to No 2, 51:324-332

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested monocalcium phosphate Gigiena I Sanitaria, 52 (MCP) 21 7758-23-8 (12):87, 1987 1987 ? Gigiena I Sanitaria, 52 (12):87, 1987 Studies on the nutrition of salmoid monocalcium phosphate Knox D, Cowey CB and fish. The magnesium requirements of dihydrate (MCP) 21 7758-23-8 Adron JW 1981 rainbow trout (Salmo gairdneri) fish Br. J. Nutr:45 Larson H W E monocalcium phosphate Preparation and properties of mono-, (MCP) 21 7758-23-8 1935 di- and tricalcium phosphates. N/A Industrial and engineering chemistry.7 monocalcium phosphate Lehr JR, Brown WE and Chemical behaviour of monocalcium (MCP) 21 7758-23-8 Brown EH 1959 phosphate monohydrate in soils. Soil Sci. Soc. Am. Proc. 23: 3-12 The physiological response of peritoneal tissue to certain industrial Calcium phosphate dust 21 7758-23-8 Miller JW 1936 and pure mineral dusts guinea pig Public health reports. 51(49):1677-1688 Response of growing Pekin ducks to supplementation of monobasic monocalcium phosphate calcium phosphate to low (MCP) 21 7758-23-8 Rodehutscord M et al 2003 phosphorus diets duck Poult. Sci. 82(2):309-319.

Comparative studies with three-week- old chickens, turkeys, ducks and quails on the response in phosphorus monocalcium phosphate utilization to a supplementation of (MCP) 21 7758-23-8 Rodehutscord M et al 2005 monobasic calcium phosphate turkey, duck Poult. Sci. 82(2):309-319. monocalcium phosphate the effects of salts on the dissolution (MCP) 21 7758-23-8 Taylor AW and Gurney EL 1965 of monocalcium phosphate Soil Sci Soc Am J. 29:151-153 monocalcium phosphate Yakovleva, Efimova, dihydromoncalcium phosphate in the (MCP) 21 7758-23-8 Shafranskii 1979 x-ray therapy fo tumours Animal ? med radiol 24: 16-19 calcium phosphate [ in the system: Ca(OH)2-H3P)4- Ion association in calcium phosphate KCl-H2O ] 21 7758-23-8 Zhang J 1991 solutions at 37°C. N/A Journal of solution chemistry. 20:5 455-465 Characterization of acid-base Fredeen AH, DePeters EJ disturbances and effects on calcium monocalcium phosphate 21 7758-23-8 and Baldwin RL 1988 and phosphorus balances of dietary goats J Anim Sci 1988. 66:159-173

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Teratologic evaluation of FDA 71-81, (monocalcium phosphate; monocalcium phosphate monohydrate) in mice, rats and (MCP) 21 7758-23-8 Morgareidge K 1974 rabbits rats/mice NTIS PB234866 Effects of dietary phosphorus and starch levels on growth performance, body composition and nutirent Liang J-J, Liu Y-J, Tian L- utilization of grass carp Monocalcium phosphate 21 7758-23-8 X, Yang H-J & Liang G-Y 2012 (Ctenopharyngodon idella Val) Fish Aquaculture Research. 43: 1200-1208 Phosphorus/phospate in Present knowledge in nutrition Tenth edition, general (form not chapter 29 (Erdman JW Jr & MacDonald IA specified), CaHPO4 21 7758-23-8 Heaney RP 2012 Phosphorus Man (Eds)): 447-458 Monokalsiumfosfaatti ja ureafosfaatti seka kasittelematon Monocalciumphosphate, olki ja ammoniakilla kasitelty olki ureaphosphate 21 7758-23-8 Kommeri M, Rissanen H 1985 mullien ruokinnassa Cattle Tiedote - Maatalouden Tutkimuskeskus. 24: 31-40 ISSN 0359-7652 Effects of two levels of phosphorus Brintrup R, Mooren T, intake on performance and Meyer U, Spiekers H & faecal phosphorus excretion of dairy J. Anim. Physiol. a. Anim. Nutr. 69 (1993), 29- monocalcium phosphate 21 7758-23-8 Pfeffer E 1993 cows cows 36 Effects of Neutral Phytase Supplementation on Biochemical Parameters in Grass Carp, Ctenopharyngodon idellus, and Gibel Carp, Carassius auratus gibelio, Fed Liu L, Luo Y, Liang XF, Different Levels of Journal of the world aquaculture society. 44(1): monocalcium phosphate 21 7758-23-8 Wang W & Wu J 2013 MonocalciumCalcium orthophosphates. Phosphate fish 56 Applications in Nature, Biology and ISBN 978-981-4316-62-0 (Hardcover) calcium orthophosphates 21 various Dorozhkin S 2012 Medicine N/A ISBN 978-981-4364-17-1 (eBook) calcium orthophosphates 21 various Dorozhkin S 2007 Calcium orthophosphates N/A J Mater Sci (2007) 42:1061–1095 Review Calcium Orthophosphates in Nature, calcium orthophosphates 21 various Dorozhkin S 2009 Biology and Medicine N/A Materials 2009, 2, 399-498; calcium A clinical test of addition of hydrogenorthophosphate 22 7757-93-9 Averill H.M. And Bibby B.G. 1964 phosphates to the diet of children human J. D. Res suppl to num 6, 43: 1150-1155 effect on dental caries of a dentifrice calcium containing stannous fluoride and hydrogenorthophosphate 22 7757-93-9 Muhler J.C. 1957 dicalcium phosphate human J. D. Res. 36(3): 399-402

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Anticariogenic effect of dicalcium dicalcium phosphate phosphate dihydrate chewing gum: dihydrate 22 7789-77-7 Richardson A.S. Et al 1972 result after two years human J Canad Dent Asso 6: Initial submission: Primary skin irritation of sodium calcium Bullock CH and Kamienski hexametaphosphate, powdered, in Stauffer Western RC NTIS OTS0555931 (T- hydrogenorthophosphate 22 7757-93-9 FX 1972 rabbits Rabbits 1861) Transformation of dibasic calcium phosphate dihydrate and octacalcium dibasic calcium phosphate phosphate in slightly acid and dihydrate 22 7789-77-7 Bell L.C. And Black C.A. 1970 alkaline soils soil soil sci soc amer proc 34: 583-587 Urea phosphate and mono- ammonium phosphate as dietary supplements for sheep fed diets calcium Fishwick G and inadequate in phosphorous and hydrogenorthophosphate 22 7757-93-9 Hemingway RG 1973 nitrogen Sheep J. agric. Sci. Cam. 81: 139-143 Energy and Phosphorus Status as Factors Affecting Postpartum calcium Carstairs JA, Neitzel RR Performance hydrogenorthophosphate 22 7757-93-9 and Emery RS 1981 and Health of Dairy Cows cows Journal of Dairy Science. 64(1) calcium Cerosaletti PE, Fox DG and Phosphorus Reduction Through hydrogenorthophosphate 22 7757-93-9 Chase LE 2004 Precision Feeding of Dairy Cattle cows J. Dairy Sci. 87:2314–2323 N. R. Combs, E. T. Calcium and phosphorus Kornegay, M. D. requirement of swine from weaning calcium Lindemann and D. R. to market weight: I. Development of hydrogenorthophosphate 22 7757-93-9 Notter 1991 response curves for performance pig J Anim Sci 1991. 69:673-681. Reliability of Dietary Ca and P Levels and Bone Mineral Content as Predictors of Bone Mechanical calcium Properties at Various Time Periods in hydrogenorthophosphate 22 7757-93-9 Crenshaw TD 1986 Growing Swine pig J Nutr. 116:2155-2170 Effect of various calcium:phosphorus ratios at low and high dietary calcium G. A. Reinhart and D. C. phosphorus for starter, grower and hydrogenorthophosphate 22 7757-93-9 Mahan 1986 finishing swine pig J. Anim. Sci. 1986.63:457-466

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Health hazard evaluation/toxicity Dicalcium phosphate dust determination. Arco polymer (DCP) 22 7757-93-9 NTIS 1974 incorporated , Monaca, Pennsylvania N/A N/A

Solubility and solubility product of calcium dicalcium phosphate dihydrate in hydrogenorthophosphate 22 7757-93-9 Bennett AC and Adams F 1976 aqueous solutions and soil solutions. Soil Sci Soc Am J. 40(1): 39-42 The determination of retainable phosphorus, relative biological Dicalcium phosphate, availability, and relative biological Defluorinated phosphate value of phosphorus sources for 22 7757-93-9 Coon CN et al 2007 broilers chicken Poult. Sci. 86:857-868. Versuche zur ermittlung calcium Domontovitch MK and loslichkeitsproducts von hydrogenorthophosphate 22 7757-93-9 Sarubina OV 1925 dicalciumphosphat N/A Biochem Z. 163: 646-9 The instability constant and hydrogen calcium ion dissociation of calcium hydrogen hydrogenorthophosphate 22 7757-93-9 Greenwald I 1963 phosphate. N/A J Phys Chem. 67:2853-2854 Solubility of CaHPO4.2H2O in the Calcium system Ca(OH)2-H3PO4-H2O, at 5, Journal of Research of the National Bureau of hydrogenorthophosphate 15, 25, and 37.5°C. J. Res. Nat. Bur. standards. A. Physics and Chemistry. 74A(4): dihydrate (DCP) 22 7757-93-9 Gregory TM et al 1970 Stand – A. N/A 461-475. Inactivation of Transmissible Spongiform Encephalopathy agents calcium during the manufacture of Dicalcium Hamster and hydrogenorthophosphate 22 7757-93-9 Grobben AH et al 2006 phosphate from bone. mouse Veterinary Record, 158: 361-366 ABSTRACT: magnesium ammonium calcium phosphate as a mineral supplement hydrogenorthophosphate 22 7757-93-9 Hemingway R.G. Et al 1967 for growing lambs Nutrition society: 24 The effects of dietary minerals and calcium Johnson RJ and electrolytes on the growth and hydrogenorthophosphate 22 7757-93-9 Karunajeewa H 1985 physiology of the young chick. Chicken J. Nutr. 115: 1680 – 1690 Chemical and Physical Evaluations of Commercial Dicalcium dicalcium phosphate Phosphates as Sources of dihydrate (DCP) 22 757-93-9 Lima FR et al 1995 Phosphorous in Animal Nutrition. N/A Poultry Sci, 47: 1659-167 dicalcium phosphate, Miller MW and Joukovsky Availability of phosphorus from defluorinated phosphate 22 7757-93-9 VV 1953 various phosphate materials chicken Poultry Sci. 32:78-81

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solubility of gypsum and dicalcium calcium phosphate phosphate dihydrate in the system dihydrate 22 7789-77-7 Moreno EC and Osborn G 1963 CaO-P2O5-SO3-H2O and in soils. Soil Sci soc Am J. 27:614-619 Dicalcium phosphate Moreno EC, Brown WE and solubility of dicalcium phosphate dihydrate 22 7789-77-7 Osborn G 1960 dihydrate in aqueous systems. Soil sci Soc Am J. 24:94-98 Sur la solubilité du phosphate bicalcique dans l’eau pure. On the solubility of dicalcium calcium phospahte in pure water. hydrogenorthophosphate 22 7757-93-9 Rindell MA 1902 N/A Comptes Rendus de l’Acad. Sci. 134:112-114. Hydrolysis of dicalcium phosphate dicalcium phosphate dihydrate in the presence or absence dihydrate 22 7789-77-7 Tung M.S. Et al 1985 of calcium fluoride water J. Dent. Res. 64(1): 2-5 Toxicity of excess dicalcium calcium Wallner-Pendleton E.A. Et Phosphate in the Diet of Turkey hydrogenorthophosphate 22 7757-93-9 al 1989 Poults turkey avian diseases 33: 375-378 Wilcox RA, Carlson CW, The availability of phosphorus from calcium Kohlmeyer WM and different sources for poults fed hydrogenorthophosphate 22 7757-93-9 Gastler GF 1955 practical-type diets turkey Poultry Science. 34: 1017-1023 Unexpected pH dependence of dicalcium phosphate dissolution kinetics of dicalcium dihydrate 22 7789-77-7 Zhang J 1994 phosphate dihydrate. J. Phys. Chem, 98 Dissolution deceleration of calcium calcium phosphate crystals at constant hydrogenorthophosphate 22 7757-93-9 Zhang J 1992 undersaturation N/A Journal of crystal growth. 123: 59-68 calcium Interpretation of dissolution kinetics hydrogenorthophosphate 22 7757-93-9 Zhang J 1992 of dicalcium phosphate dihydrate. N/A Journal of Crystal Growth. 125. 251-269 Effect of Dietary Phosphorus on dicalcium phosphate Anderson GH and Draper Calcium Metabolism in Intact and monohydrate 22 HH 1972 Parathyroidectomized Adult Rats rat the Journal of nutrition The Role of Calcium and Phosphorus calcium Edwards HM and Veltmann in the Etiology of Tibial hydrogenorthophosphate 22 7757-93-9 JR 1983 Dyschondroplasia in Young Chicks chicken J Nutr. 113:1568-1575

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EFFECTS OF DIETARY CALCIUM, PHOSPHORUS, CALCIUM: PHOSPHORUS RATIO AND VITAMIN K ON PERFORMANCE, calcium D. D. Hall, G. L. Cromwell BONE STRENGTH AND BLOOD hydrogenorthophosphate 22 7757-93-9 and T. S. Stahly 1991 CLOTTING STATUS OF PIGS pig J Anim Sci 1991. 69:646-655. Effects of zeranol and two dietary levels of calcium and phosphorus on performance, carcass and bone calcium Hutcheson JP, Greene LW, characteristics, and calcium status in hydrogenorthophosphate 22 7757-93-9 Carstens GE and Byers FM 1992 growing lambs sheep J Anim Sci 1992. 70:1346-1351. Influence of Dietary Phosphate on calcium Krishinaro GVG and Draper Bone hydrogenorthophosphate 22 7757-93-9 HH 1972 Resorption in Senescent Mice mice J. NUTRITION,102: 1143-1146. Impact of Prepartum Dietary dicalcium phosphate, Barton BA, Jorgensen NA Phosphorus Intake on Calcium monosodium phosphate 22 7757-93-9 & DeLuca HF 1987 Homeostasis at Parturition cows J Dairy Sci 70:1186-1191 calcium hydrogenorthophosphate MCDowell H, Brown WE & Solubility of calcium hydrogen (DCP) 22 7757-93-9 Sutter JR 1971 phosphate. Ion-pair formation. n/a Inorganic Chemistry. 10(8):1638-1643

Solubility of CaHPO4.2H2O and the Journal of Research of the National Bureau of calcium Moreno EC, Gregory TM & formation of ion pairs in the system Standards - A. Physics and Chemistry. hydrogenorthophosphate 22 7757-93-9 Brown WE 1966 Ca(OH)2-H3PO4-H20 at 37.5°C n/a 70(A),6: 545-553 Solubility of CaHPO4.2H2O in the Journal of Research of the National Bureau of calcium Patel PR, gregory TM & quaternary system Ca(OH)2-H3PO4- Standards. A -Physics and Chemistry. 78(A).6: hydrogenorthophosphate 22 7757-93-9 Brown WM 1974 NaCl-H2O at 25°C n/a 675-682 Bioavailability of phosphorus in Potter LM, Potchanakorn various phosphate sources using calcium M, Ravindran V and body weight and toe ash as response hydrogenorthophosphate 22 7757-93-9 Kornegay ET 1995 criteria chicks Poultry Science. 74: 813-820 Growth and blood chemistry of calcium selected clariid catfishes fed Journal of Fisheries and Aquatic Science hydrogenorthophosphate 22 7757-93-9 Adekunle AI 2011 phosphorus supplemented diets fish 6(5)545-554

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Effect of offering dairy cows diets differing in phosphorus concentration over four successive lactations: 1. calcium Ferris CP, Patterson DC, Food intake, milk production, tissue hydrogenorthophosphate 22 7757-93-9 McCoy MA & Kilpatrick DJ 2009 changes and blood metabolites cows Animal. 4(4): 545-559 Effect of reduced dietary calcium Letourneau-Montminy MP, concentration and phytase Narcy A, Magnin M, supplementation on calcium and Sauvant D, Bernier JF, phosphorus utilization in weaning Monodicalcium phosphate 22 7757-93-9 Pomar C & Jondreville C 2010 pigs with modefied mineral status Pig J Anim Sci. 88:1706-1717 The effect of dicalcium phosphate supplement in summer and winter seasons as reflected on bone blood Bakunzi F, Motsei L, phosphorus, calcium and calcium Nyirenda M, Ndou R, magnesium levels in range breeding hydrogenorthophosphate 22 7757-93-9 Dzoma B, Mwanza M 2012 beef cattle Cattle J Agric Biodivers Res. 1(4): 60-64

Long-term effects of feeding diets Odongo NE, McKnight D, without mineral phosphorus KoekKoek A, Fisher JW, supplementation on the performance calcium Sharpe P, Kebreab E, and phosphorus excretion in high- Canadian Journal of Animal Science 87(4): hydrogenorthophosphate 22 7757-93-9 France J & McBride BW 2007 yielding dairy cows cows 639-646 dicalcium phosphate, Brown WR, Krook L & Atrophic rhinitis in swine. Etiology, potassium diphosphate 22 7757-93-9 Pond WG 1966 pathogenesis and prophylaxis Cornell Veterinarian 56(1) 3-108

[IN GERMAN] Effects of free phosphoric acid as a supplement to Complete feed FTIR piglets and pigs calcium Roth Von FX, Kreuzer M on the balance sheets some minerals J. Animal. Physiol. And Anim. Nurtr. 59: 247- hydrogenorthophosphate 22 7757-93-9 and Kirchgessner 1988 (P, Ca, K, Na, Mg, Zn) ( translated) pigs 254 Phosphate supplementation, calcium Bredle DL, Stager JM, cardiovascular function, and exercise Journal of Applied Physiology. 64 (4): 1821- hydrogenorthophosphate 22 7757-93-9 Brechue WF & Farber MO 1988 performance in humans N/A 1826 Galloway SDR, Tremblay The effects of acute phosphate calcium MS, Sexsmith JR & supplementation in subjects of hydrogenorthophosphate 22 7757-93-9 Roberts CJ 1995 different aerobic fitness levels human Eur J Appl Physiol (1996) 72:224-230

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Oxygen delivery and cardiac output calcium Mannix ET, Stager JM, during exercise following oral Medicine and Science in Sports and Exercise. hydrogenorthophosphate 22 7757-93-9 Harris A & Farber MO 1990 phosphate-glucose humans 22(3): 341-347 calcium Ashley FP, Naylor MN, Clinical testing of dicalcium hydrogenorthophosphate 22 7757-93-9 Emslie RD 1974 phosphate supplemented sweets humans Brit. dent. J., 1974, 136, 361.

Effect of di-calcium phosphate on calcium Rahman MZ, Ali MY, calcium balance and body condition hydrogenorthophosphate 22 7757-93-9 Huque KS & Talukder MAI 2014 score of dairy cows fed Napier grass cows Bang. J. Anim. Sci. 43(3):197-201 tricalcium phosphate Mutagenic evaluation of compound. S. typhimuium, (refers by CAS No. to ß- FDA 75-30, tricalcium phosphate, Saccharomyces TCP) 23 7758-87-4 Brusick D 1976 NF,FCC cerevisiae Litton Bionetics Inc. NTIS PB257879

tricalcium availability of dietary phosphorus in B. Jap. Soc. Scient. Fisheries 45(12): 1527- bis(orthophosphate) 23 7758-87-4 Ogino C. et al 1979 carp and rainbow trout fish 1532 tricalcium bis(orthophosphate) (ß- Kinetics of dissolution of ß-tricalcium Journal of colloidal and interface science. 190: TCP) 23 7758-87-4 Bohner M 1997 phosphate. 37-48 tricalcium Solubility of β-Ca3(PO4)2 in the bis(orthophosphate) (ß- Gregory TM, Moreno EC, system Ca(OH)2-H3PO4-H2O at 5, Journal of Research of the National Bureau of TCP) 23 7758-87-4 Patel JM & Brown WE 1974 15, 25 and 37°C n/a standards. A. Physics and Chemistry. 78A(6): tricalcium Functional Aspects of Renal bis(orthophosphate) 23 7758.87-4 Sanderson PH 1958 Calcification in Rats rat Clinical Science. 18:67-79 Fused tricalcium Fused tricalcium phosphate as a low- phosphate, raw rock Mather RE, Pratt AD and fluorine phosphorus supplement for phosphate (P2O5) 23 231-840-8 Holdaway CW 1949 dairy cattle J Dairy Science, 32(3): 228-235 Chapuy MC, Arlot ME, DuBoeuf F, Brun J, Crouzet B, Arnaud S, Delmas P & Vitamin D3 and calcium to prevent β-tricalcium phosphate 23 7758-87-4 Meunier PJ 1992 hip fractures in elderly women human N Engl J Med 1992;327:1637-42.

Effect of a Bone Graft Substitute Qiu T, Wang Y, Han Y, βTricalcium Phosphate on Journal of Wuhan University of Technology- β-tricalcium phosphate 23 7758-87-4 Jiang X & Li S 2012 Osteoblastic Genes mRNA Exprssion Mater. Sci. Ed. 911 - 915 β-tricalcium phosphate unknown (in Japanese) Ames test (title unknown in [NANO] 23 7758-87-4 Chen? 2005 Japanese) bacteria J Clin Stomat ol ,Dec, 2005, Vol. 21, No. 12

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The Absorption of Tricalcium Phosphate and its Acute Metabolic β-tricalcium phosphate 23 7758-87-4 Shires R & Kessler GM 1990 Effects humans Calcif Tissue Int (1990) 47:142-144 The Acute Metabolic Effects of Oral Tricalcium Phosphate and β-tricalcium phosphate 23 7758-87-4 Yang RS, Liu TK & Tsai KS 1994 Calcium Carbonate humans Calcif Tissue Int (1994) 55:335-341 Tavares DS, Castro LO, Synthesis and cytotoxicity evaluation Soares GDA, Alves GG & of granular magnesium substituted β- β-tricalcium phosphate 23 7758-87-4 Granjeiro JM 2013 tricalcium phosphate n/a J Appl Oral Sci. 21(1): 37-42 Initial submission: Primary skin irritation of sodium Bullock CH and Kamienski hexametaphosphate, powdered, in Stauffer Western RC NTIS OTS0555931 (T- tricalcium phosphate (TCP) 24 1306-06-5 FX 1972 rabbits Rabbits 1861)

In vitro effects of fluor- HAP (24) (also looks at Jantova S, Theisova M, hydroxyapatite, fluorapatite and fluorinated compounds in Letasiova S, Birosova L hydroxyapatite on colony formation, microorganism comparison to HAP) 24 1306-06-5 and Palou TM 2008 DNA damage and mutagenicity. s Mutation Research. 625:139-144 tricalcium phosphate (as Gastrointestinal tolerance of oral ‘posture’) 24 12167-74-7 O’Connell MA et al 1989 calcium supplements human Clin pharm. 8: 425-427. Ossopan’ - Reid IR, Hannan SF, microcrystalline Shooler BA and Ibbertson The acute biochemical effects of four hydroxyapaptite 24 1306-06-5 HK 1986 proprietary calcium preparations. human Aust NZ J Med. 16: an immunological study of tricalcium phosphate supplied by three different tricalcium phosphate (TCP) 24 12167-74-4 Sasaoka K. et al 1989 manufacturers guinea pigs J. Clin. Lab. Immunol. 30: 197-202

Mallaiah K.V., Padma Effect of phosphorous nutrition on Rami Y. and Vijaya growth and sporulation of Alternaria tricalcium phosphate 24 12167-74-7 Lakshmi M. 1981 macrospora and Drechslera rostrata fungus indian j. microbiol 21: 169-170

T. Castaneum, pathological changes induced in C. Cephalonica, tricalcium phosphate (TCP) 24 12167-74-4 Bano, A., Majumder, S.K. 1965 insects E. Cautella J. of Invertebrate pathology 7

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Tricalcium phosphate, Defluorinated phosphate rock, defluorinated Nutrative evaluation of deflourinated superphosphate, phosphates and other phosphorous supplements. II. Defluorinated 24 12167-74-7 Bird HR, Mattingly JP 1945 phosphates chicken J Assoc of Agric Chem. 28:118-129 Formation of hydroxyapatite at low hydroxyapatite (HAP) 24 1306-06-5 Boskey AL 1976 supersaturation. N/A The Journal of physical chemistry. 80:1 40-45 The mechanism of dissolution of hydroxyapatite and carbonated hydroxyapatite (HAP) 24 1306-06-5 Budz JA 1988 apatite in acidic solutions. N/A Journal of crystal growth. 91:490-496 Physico-chemical characterization HAP (Gen-OxTM – natural, and biocompatibility evaluation of HA-U-synthetic) 24 1306-06-5 Cabral da Cruz AC et al 2006 hydroxyapatites N/A Journal of Oral Science. 48(4): 219-226 Solubility criteria for the existence of hydroxyapatite (HAP) 24 1306-06-5 Clark JS 1955 hydroxyapatite. N/A Canadian journal of chemistry. 33:1696-1700 The preparation of hydroxyapatite, Hydroxyapatite (HAP) 24 1306-06-5 Clark LM and Gerrard WF 1938 3[Ca3(PO4)2], Ca(OH)2 N/A J Soc Chem Ind, 7: 295-297 Danneel H and Frohlich Uber das system tricalcium phosphat tricalcium phosphate (TCP) 24 1306-06-5 KW 1930 und wasser N/A Z. Anorg Chem 188:14-31 structure of DNA – binding to calf thymus Indian Journal of biochemistry and biophysics hydroxyapatite (HAP) 24 1306-06-5 Dutta. S., Sasisekharan V. 1982 hydroxyapatite as a probe DNA 19: 71-74 JCPDS-International Centre for Diffraction Elliott JC, Wilson RM and Data 2002, Advances in X-ray analysis. 45: hydroxyapatite (HAP) 24 1306-06-5 Dowker SEP 2002 Apatite structures N/A 172- Toxicity of Hydroxyapatite in vitro : Hydroxyapatite (HAP) 24 1306-06-5 Evans EJ 1990 the effect of particle size. N/A Biomaterials, 12: 574-576 Studies on the Mechanisms of cell damage by finely ground Hydroxyapatite (HAP) 24 1306-06-5 Evans EJ et al 1991 Hydroxyapatite Particles in vitro N/A Clinical materials, 7: 241-245 Infrared studies of apatites. I. Vibrational assignments for calcium, strontium and barium hydroxyapatites utilising isotopic hydroxyapatite (HAP) 24 12167-74-4 Fowler BO 1973 substitution n/a Inorganic Chemistry. 13:194-214

Solubility behaviour of dental enamel Hydroxyapatite (HAP) 24 1306-06-5 Francis MD 1965 and other Calcium Phosphates N/A Ann NY Acad Sci, 131(2): 694-712

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Effect of dietary calcium phosphate and zinc supplementation on whole body zinc concentration of rainbow tricalcium phosphate (TCP) 24 12167-74-7 Hardy RW and Shearer KD 1985 trout (Salmo gairdneri). fish Can. J. Fish. Aquat. Sci. 42: 181-185 Dental materials which contain tricalcium phosphate 24 12167-74-7 Heil J 1996 Genotoxicity of dental materials N/A Mutation Research 368: 181-194 The Solubility behaviour of Hydroxyapatite (HAP) 24 1306-06-5 La Mer VK 1962 hydroxylapatite N/A J Phys Chem, 55: 973-978

reversion of the toxicity of tricalcium tricalcium phosphate (TCP) 24 12167-74-4 Majumder S.K., Bano A. 1966 phosphate to insects by Trehalose insects Nature 210: 1052-1053 Calcium phosphate biomaterials: a Hydroxylapatite coatings in orthopaedic hydroxyapatite (HAP) 24 1306-06-5 Manley MT 1993 review of the literature. surgery. 1-23 Biological effects of calcium hydroxyapatite crystals in breast Hydroxyapatite (HAP) 24 1306-06-5 McCarthy G 2001 cancer solubility of Ca5(PO4)3OH in the Journal of research of then Nation Bureau of McDowell H, Gregory TM system Ca(OH)2-H3PO4-H2O at 5, Standards A. Physics and Chemistry. 81A (2 hydroxyapatite (HAP) 24 1306-06-5 and Brown WE 1977 15, 25 and 37°C. N/A and 3): 273- 281 calcium hydroxyapatite promotes mitogenesis and matrix metalloproteinase expression in human tissue hydroxyapatite (HAP) 24 1306-06-5 Morgan M.P. 2001 human breast cancer cell lines cells molecular carcinogenesis 32: 111-117 Niwa S, Sawai K, Experimental studies on the Takahashi H, Tagai H, Ono implementation of hydroxyapatite in hydroxyapatite (HAP) 24 1306-06-5 M and Fukuda Y 1980 the medullary canal of rabbits. rabbit Influence of the purity of tricalcium Rao M.R., Venugopal J.S. phosphate on its toxicity to stored- insect tricalcium phosphate (TCP) 24 12167-74-4 And Majumder S.K. 1971 product insects (tribolium) Life science 10(II): 1081-1088 basic calcium phosphate Rootare HM, Deitz VR and solubility product phenomena in (HAP) 24 1306-06-5 Carpenter FG 1962 hydroxyapatite water systems. N/A Journal of colloid science. 17:179-206

Effect of dietary tricalcium phosphate tricalcium phosphate (TCP) 24 1306-06-5 Satoh S et al 1987 on availability of zinc to rainbow trout fish Nippon Suisan Gakkaishi. 53(7): 1199-1205

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Effect of supplemental phytate and/or tricalcium phosphate on weight gain, feed efficiency and zinc content in tricalcium phosphate (TCP) 24 1306-06-5 Satoh S et al 1989 vertebrae of channel catfish. fish Aquaculture. 80: 155-161

The estimation of acid needed to obtain a saturated solution in hydroxyapatite (HAP) 24 1306-06-5 Smith AN 1975 equilibrium with solid hydroxyapatite. N/A Journal of Colloid and Interface Science, 54:2 A model describing the kinetics of hydroxyapatite (HAP) 24 1306-06-5 Smith AN 1977 dissolution of hydroxyapatite. N/A Journal of Colloid and Interface Science, 62:3 Incongruent dissolution and surface hydroxyapatite (HAP) 24 1306-06-5 Smith RN 1974 complexes of hydroxyapatite N/A Journal of Colloid and Interface Science, 48:3 Short-term carcinogen-induced hydroxyapatite (HAP) 24 1306-06-5 Stewart BW 1976 structural changes in DNA in vivo. N/A IARC Scientific Publications. No. 12 : 343-350 Solubility products of di—and 24: HAP trimagnesium phosphates and the di- and tri- Magnesium dissociation of magnesium phosphate 24 1306-06-5 Taylor AW 1963 phosphate solutions. N/A Trans Faraday Soc. 59: 1580-1584 Kinetics of dissolution of calcium hydroxyapatite powder. III: pH and hydroxyapatite (HAP) 24 1306-06-5 Thomann JM 1990 sample conditioning effects N/A Calcif Tissue Int. 46:121- 129. Toth JM, Hirthe WM, hubbard WG, Brantley WA Determination of the ratio of HA/TCP hydroxyapatite / TCP 24 12167-74-7 & Lynch KL 1991 mixtures by x-ray diffraction n/a Journal of Applied Biomaterials. 2:37-40 Effect of Supplemental Tricalcium Satoh SH, Izume K, Phosphate on Zinc and Manganese tricalcium phosphate 24 12167-74-7 Takeuchi T and Watanbe T 1992 Availability to Common Carp fish Nippon Suisan Gakkaishi. 58(3): 539-545 Journal of Research of then Nation Bureau of Avnimelech Y, Moreno EC Solubility and surface properties of Standards A. Physics and Chemistry. 77A. 1: hydroxyapatite 24 1306-06-5 & Brown WE 1972 finely divided hydroxyapatite n/a 149-155 The solubility of bone mineral. I Levinskas GJ & Neuman solubility studies of synthetic Hydroxyapatite (HAP) 24 1306-06-5 WF 1954 hydroxylapatite. n/a Journal of chemistry. C. 59. 164-169 Adsorption on and surface chemistry hydroxyapatite 24 1306-06-5 Misra DN 1982 of hydroxyapatite n/a textbook: Plenum Press Journal of Research of the National Bureau of Moreno EC, Gregory TM & Preparation and solubility of Standards - A. Physics and Chemistry. hydroxyapatite 24 1306-06-5 Brown WE 1968 hydroxyapatite n/a 72(A),6: 545-554

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Letters to the editor: On the hydroxyapatite 24 1306-06-5 Pearce EIF 1988 dissolution of hydroxyapatite in acids n/a Journal of Dental Research. 67(7): 1056-1058 Surface properties of alkaline earth Journal of Electroanalytical Chemistry and hydroxyapatite 24 1306-06-5 Saleeb FZ & De Bruyn PL 1972 apatites n/a Interfacial Electrochemistry. 37: 99 - 118 Verbeek RMH, Steyaer H, Solubility of synthetic calcium hydroxyapatite 24 1306-06-5 Thun HP & Verbeek F 1980 hydroxyapatites n/a Faraday discussions. 1(76): 209-219 Wier D R, Chien SH & hydroxyapatite 24 1306-06-5 Black CA 1971 Solubility of hydroxyapatite n/a Soil Science. 111(2): 107 - 112 Kinetics and mechanism of hydroxyapatite crystal dissolution in Wu MS, Higuchi WI, Fox weak acid buffers using the rotating hydroxyapatite 24 1306-06-5 JL & Friendman M 1967 disk method. n/a Journal of Dental Researc. 55(3): 496-505

Changes in toxicity and bioavailability of lead in contaminated soils to the earthworm Eisenia fetida (Savigny Davis NA, Hodson ME & 1826) after bone meal amendments Environmental Toxicology and Chemistry, Vol. bone ash 24 68439-86-1 Black S 2002 to the soil. earthworm 21, No. 12,:2685–2691

Zhao X, Ong KJ, Ede JD, Evaluating the toxicity of Stafford JL, Ng KW, Goss hydroxyapatite nanoparticles in Hydroxyapatite 24 12167-74-7 GG & Loo SCJ 2012 Catfish cells and Zebrafish embryos Fish Wiley Online Library Postprandial effects of calcium phosphate supplementation on plasma concentration-double-blind, pentacalcium hydroxy- Trautvetter U, Kiehntopf M placebo-controlled cross-over human triphosphate 24 12167-74-7 & Jahreis G 2013 study humans Nutrition Journal 2013, 12:30

Reginster, Denis D, Bartsch Acute biochemical variations induced V, Deroisy R, Zegels B & by four different calcium salts in tricalcium phosphate 24 12167-74-7 Franchimont P 1993 healthy male volunteers humans Osteoporosis International. 3: 271-275

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Fetuin-A and Albumin Alter Cytotoxic Effects of Calcium Dautova Y, Kozlova D, Phosphate Nanoparticles on Human CaP nanoparticles - likely Skepper JN, Epple M, Vascular Smooth PLOS One 9(5): e97565 hydroyapatite 24 1306-06-5 Bootman MD, Proudfoot D 2014 Muscle Cells cells doi:10.1371/journal.pone.0097565 determination of oxidative stress related toxicity on repeated dermal Valappil MP, Santhakumar exposure of hydroxyapatite hydroxyapatite 24 1306-06-5 S & Aruymugam S 2014 nanoparticles in rats rat International Journal of Biomaterials; 8 pages biodegredation of a nano- nano- hydroxyapatite / collagen composite hydroxyapatit/collagen Cui FZ, Du C, Su XW, Zhu by peritoneal monocyte- composite 24 n/a XD & Zhao NM 1996 macrophages n/a Cells and materials vol 6 (1-3): 31-44

Sonmez E,Cacciatore I, Toxicity assessment of Bakan F, Turkez H, Mohtar hydroxyapatite nanoparticles in rat nano-hydroxyapatite 24 n/a YI, Togar B & Stefano AD 2015 liver cell model in vitro liver hepatcytes Human and Experimental Toxicology. 1-11 Nano-hydroxyapatite and Nano titanium Dioxide Exhibit Different Subcellular Distribution and Tay CW, Fang,W, Apoptotic Profile in Human Oral ACS Appl. Mater. Interfaces 2014. 6, 6248- nano-hydroxyapatite 24 n/a Setyawati MI, Chia SL et al 2014 Epithelium epithelial cells 6256

Turkeza H, Yousef ML, Evaluation of cytotoxic, oxidative Sönmez E, Togare B, stress and genotoxic responses of Bakanf F, Soziog P and Di hydroxyapatite nanoparticles on human blood nano-hydroxyapatite 24 n/a Stefanog A 2014 human blood cells cells Journal of Applied Toxicology. 34: 373–379 Wang L, Zhou G, Liu H, Nano-hydroxyapatite particles induce Niu X, Han J, Zhengac L & apoptosis on MC3T3-E1 cells and nano-hydroxyapatite 24 n/a Fan Y 2012 tissue cells in SD rats rat cells Nanoscale, 2012, 4, 2894 Effects of four types of hydroxyapatite nanoparticles with different nanocrystal morphologies Xu Z, Liu C, Weib J and and sizes on apoptosis in rat nano-hydroxyapatite 24 n/a Suna J 2012 osteoblasts rat cells J. Appl. Toxicol. 2012; 32: 429–435 Liu Li-ping , Xiao Yan-bing , Xiao Zi-wen , Wang Zhi- Toxicity of hydroxyapatite nano-hydroxyapatite 24 n/a biao, et al 2005 nanoparticles on rabbits rabbit JOURNAL OF HYGIENE RESEARCH. 34(4)

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The effect of calcium phosphate nanoparticles on hormone production and apoptosis in human granulosa Reproductive Biology and Endocrinology 2010, nano-hydroxyapatite 24 n/a Liu X, Qin D & Ciu Y et al, 2010 cells human cells 8:32 Integrated risk assessment of a hydroxyapatite–protein-composite for use in oral care products: A Regulatory Toxicology and Pharmacology 59 nano-hydroxyapatite 24 n/a Scheel J & Hermann M 2011 weight-of-evidence case study N/A (2011) 310–323

Exposure of the murine RAW 264.7 macrophage cell line to hydroxyapatite dispersions of various composition and morphology: Assessment of cytotoxicity, activation nano-hydroxyapatite 24 n/a Scheel J, Weimans S et al 2009 and stress response CELLS Toxicology in Vitro 23 (2009) 531-538

Evaluation of cytotoxic effects and oxidative stress with hydroxyapatite Albrecht C, Scherbert AM, dispersions of different van Berlo D, Braunbarth physicochemical properties in rat CM, Schins RPF & Scheel NR8383 cells and primary nano-hydroxyapatite 24 n/a J 2009 macrophages rat cells Toxicology in Vitro 23 (2009) 520-530 Hepatotoxicity and liver injury induced by hydroxyapatite nano-hydroxyapatite 24 n/a Che, Xue & Sun 2014 nanoparticles rat liver cells J. Appl. Toxicol. 2014; 34: 1256–1264

Cells-nano interactions and molecular toxicity after delayed hypersensitivity, in Guinea pigs on GeethaCS, Remya NS, Leji exposure to hydroxyapatite Colloids and Surfaces B: Biointerfaces 112 nano-hydroxyapatite 24 n/a KB, et al 2013 nanoparticles guinea pig (2013)204-212

Hafez AI, Hafez F, Kehdr Safety evaluation of needle-like M, Ibrahim O, Sabry R & hydroxyapatite nanoparticles in nano-hydroxyapatite 24 n/a Abbdel-Wahhab MA 2012 female rats rats Egypt Pharm J 11:67–72

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Effect of Particle Size of Dingf T, Xue Y, Lu H, Hydroxyapatite Nanoparticles on its IEEE TRANSACTIONS ON nano-hydroxyapatite 24 n/a Huang Z & Sun J 2012 Biocompatibility mice and rats NANOBIOSCIENCE, VOL. 11. NO. 4, Effect of calcium phosphate and vitamin D3 supplementation on bone Trauveter U, Neef N, remodelling and metabolism of Leitherer M, Kiehnhopf M, calcium, phosphorus, magnesium tricalcium phosphate 24 12167-74-7 Kratzsch J & Jahreis G 2014 and iron humans Nutrition Journal 2014, 13:6 Scientific Committee on Consumer Safety SCCS OPINION ON Hydroxyapatite 24 n/a SCCS 2015 Hydroxyapatite (nano) n/a SCCS/1566/15 Sequential study of Pleural Peritoneal and blood cells in acute pleurisy Induced by Calcium Pyrophosphate Calcium Pyrophosphate 25 14866-19-4 Bachelet CM et al 1987 in the Rat. rat Experimental Lung Research, 13:241-252 the effects of calcium acid phosphate calcium acid phosphate on dental caries in children: a (CAPP) 25 14866-19-4 Ship I.I. And Mickelsen O. 1964 controlled clinical trial human J. D. res suppl num 6, 43: 1144-1149 Calcium pyrophosphate dihydrate (monoclinic), Roch-Arveiller M, Legros R, calcium pyrophosphate Chanaud B, Muntaner O, dihydrate (triclinic) and Strzalko S, Thuret A, Inflammatory reactions induced by calcium pyrophosphate Willoughby DA and Giroud various calcium pyrophosphate anhydrous ( β) 26 JP 1990 crystals. rat Biomed and Pharmacother. 44: 467-474 monoclinic or triclinic calcium pyrophosphate dihydrate crystals, ‘apatitie’ Comparison of the acute crystals (could be HAP, inflammation induced by calcium fluoroapatite, chlorapatite pyrophosphate dihydrate, apatite and or bromapatite – not Watanabe W, Baker DG mixed crystals in the rat air pouch stated) 26 and Schumacher HR 1992 model of a synovial space chicks J Rhumatol 19(9): 1453-1457

Lee JH, Chang B-S, Ryu A 90-day subchronic toxicity study of β-calcium pyrophosphate 26 232-221-5 HS and Lee C-K 2009 beta-calcium pyrophosphate in rat Drug and Chemical Toxicology, 32(3): 277-282

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Initial submission: Primary skin irritation of sodium Bullock CH and Kamienski hexametaphosphate, powdered, in Stauffer Western RC NTIS OTS0555931 (T- Ferric phosphate (FeP) 27 10045-86-0 FX 1972 rabbits Rabbits 1861) Responses of the earthworm Lumbricus terrestris (L.) to iron phosphate and metaldehyde slug Ferric phosphate (FeP) 27 10045-86-0 Langan MA and Shaw EM 2006 pellet formulations. earthworms Applied soil ecology, 34: 184-189 Mutagenic evaluation of compound FDA 73-84 Ferric ortho phosphate Yeast and iron phosphate (FeP) 27 10045-86-0 Brusick D 1975 white food grade, phase I Bacteria NTIS Sodium iron pyrophosphate Biological Availability of Iron Ferric orthophospahte Supplements for Rats, Chicks and Rats, chicks, 27 10045-86-0 Pennell MD et al 1976 Humans humans Journal of Nutrition, 106(2): 265-274

A new low-toxicity slug control Iron phosphate (FeP) 27 10045-86-0 Caldwell B 2001 material for strawberries. Slug NYS IPM program Genotoxicity of Iron Compounds in Salmonella Typhimurium and Environmental and Molecular Mutagenesis, 33: Iron phosphate (FeP) 27 10045-86-0 Dunkel VC et al 1999 L5178Y Mouse Lymphoma Cells mouse 28-41 The relative toxicity of metaldehyde and iron phosphate-based iron phosphate (FeP) 27 10045-86-0 Edwards CA et al 2009 molluscicides to earthworms Earthworms Crop protection, 28: 289-294

Estimation of the bioavailability of Iron phosphate (FeP) 27 10045-86-0 Fritz JC et al 1975 iron. Journal of the AOAC. 58(5): 902-905

Field tests with a molluscicide iron phosphate (FeP) 27 10045-86-0 Speiser B and Kistler C 2002 containing iron phosphate Slug Crop protection 21: 389-394

A compilation of two decades of bacteria mutagencity test resuls with the salmonella Seifried HE, Seifried RM, Ames Salmonella typhimurium and (ames test), Ferric phosphate (FeP) - Clarke JJ, Junghans TB L5178Y Mouse lymphoma cell mouse hydrate 27 51833-68-2 and San RHC. 2006 mutation assays. lymphoma cells Chem. Res Toxicol. 19: 627-644 Prepared for the EU Review report for the active Ferric phosphate (FeP) 27 10045-86-0 Commission 2002 substance ferric phosphate Human European Commission

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Carter SR and Hartshorne The System Ferric Oxide-Phosphoric Iron phosphate (FeP) 27 10045-86-0 NH 1923 Acid – Water. A New Phosphate N/A J Chem Soc Trans 123: 2223-2233

Iron phosphate (FeP) 27 10045-86-0 Chang SC and Jackson ML 1957 Solubility product of iron phosphate. water and soil Soil Sci Soc Am J. 21:265-269 Hazardous Substances Hazardous Substances Data Bank, Ferric phosphate (FeP) 27 10045-86-0 Data Bank, 2004 Ferric phosphate Human TOXNET complexes invloving tervalent iron and orthohposphoric acid. Part III. The system ferric oxide-phosphoric Ferric phosphate (FeP) 27 10045-86-0 Jameson RF and Salmon 1954 oxide-water at 25° N/A J Chem Soc. Unknown vol: 28-34

Effect of dietary iron level on Mahoney AW and efficiency of converted food iron into Ferric phosphate (FeP) 27 10045-86-0 Hendricks DG 1976 haemoglobin by the anaemic rat. rat Nutr. Metabol. 20: 222-227 Rat, bird, fish, aquatic invertebrates, algae, Environmental fate - Ecotoxicology - earthworms, Human Health Ferric Phosphate arthropods, Iron phosphate (FeP) 27 10045-86-0 N/A 1997 PPDB human PPBD (data base) Prepared for the EU Review report for the active Ferric phosphate (FeP) 27 10045-86-0 Commission 2002 substance ferric phosphate Rat European Commission Mouse, Prepared for the EU Review report for the active hamster, Ferric phosphate (FeP) 27 10045-86-0 Commission 2002 substance ferric phosphate guinea pig European Commission The effects of metals on the chick Ridgway LP and Karnofsky embryo: toxicity and production of iron phosphate (FeP) 27 10045-86-0 DA 1952 abnormalities in development. chick embryo Ann N Y Acad Sci: 203-215

An iron-based T1 contrast agent made of iron-phosphate complexes: Iron phosphate (FeP) 27 10045-86-0 Rodriguez E et al 2007 In vitro and in vivo studies. mice Magn reson Mater Phy, 20: 27-37 Synthesis, Characterization, and Bioavailability in Rats of Ferric Iron phosphate (FeP) 27 10045-86-0 Rohner F et al 2007 Phosphate Nanoparticles Rats The Journal of Nutrition, 137: 614-619

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complexes invloving tervalent iron and orthophosphoric acid. Part II. Ion- exhange studies of solutions iron phosphate (FeP) 27 10045-86-0 Salmon JE 1952 containing phosphate and chloride n/a J Chem soc: 2644-2650 Provisional Evaluation of the use of "Ferramol Schneckenkorn" in Research Institute of Organic Agriculture Iron phosphate (FeP) 27 10045-86-0 Tamm L and Speiser B 2006 Organic Farming in Switzerland. Slugs/snails (FiBL), Frick, Switzerland

Scientific Opinion of the Panel on Food Additives and Nutrient Sources added to Food on a request from the European Commission on Ferrous Aguilar F, Charrondiere phosphate added for nutritional Ferrous phospate 27 10045-86-0 UR, Dusemund B et al 2009 purposes to food supplements. The EFSA Journal, 951: 1-13

United States Environmental Protection Ferric orthophosphate 27 10045-86-0 Cerrelli S 1998 Pesticide fact sheet Slug & snail Agency Fidler MC, Walczyk T, Davidsson L, Zeder C, A micronized, dispersible ferric Sakaguchi N, Juneja LR pyrophosphate with high relative Iron pyrophosphate (FePP) 28 10058-44-3 and Hurrel RF 2004 bioavailability in man. human British Journal of Nutrition. 91:107-112 Effects of Ascorbic acid on Interactions between Ciprofloxacin and Ferrous Sulphate, Sodium Ferric pyrophosphate Ferrous Citrate or Ferric (FePP) 28 10058-44-3 Motoya T et al 2000 Pyrophosphate, in mice. mice J Pharm Pharmacol 52:397-401 Salt Dual-Fortified with Iodine and Micronized Ground Ferric Pyrophosphate Affects Iron Status ferric pyrophosphate but Not Hemoglobin in Children in (FePP) 28 10058-44-3 Wegmuller R et al 2006 Cote d'Ivoire. Human Journal of Nutrition, 136(7): 1814-1820 Mutagenicity and DNA-damaging activity caused by deomposed Kitano K, Fukukawa T, products of potassium sorbate bacteria Ohtsuji Y, Matsuda T and reacting with ascorbic acid In the salmonella Iron pyrophosphate (FePP) 28 10058-44-3 Yamaguchi H 2002 presence of Fe salt. (ames test) Food and chemical toxicology 40: 1589-1594

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Chow FC, Taton GF, Baulay JP, Lewis LD, Effect of dietary calcium, dimagnesium phosphate Remmenga EE and Hamar magnesium and phosphorous on (DMP) 29 7757-86-0 DW 1980 phosphate urolithiasis in rats. rat Investigative Urology. 17(4): 273-276 Separation and detection of condensed phosphates in waste dimagnesium phosphate Halliwell DJ, Mackelvie ID, waters by ion chromatography (DMP) 29 7757-86-0 Hart BT and Dunhill RH 1996 coupled with flow injection. n/a Analyst. 121:1089-1093. Phosphoric acid, sodium phosphates, potassium phosphates, calcium phosphates, monomagnesium phosphate, dimagnesium Food additives in Europe 2000 - phosphate, diphosphates, status of safety assessments of food triphosphates and additives presently permitted in the polyphosphates 29 7757-86-0 EU.

Joint FAO/WHO expert Magnesium dihydrogen committee on food Seventy-sixth meeting Geneva 5-14 diphosphate 29 7757-86-0 additives 2012 June 2012 Man Report number JECFA/76/SC Initial submission: Primary skin irritation of sodium trimagnesium Bullock CH and Kamienski hexametaphosphate, powdered, in Stauffer Western RC NTIS OTS0555931 (T- bis(orthophosphate) (TMP) 30 7756-87-1 FX 1972 rabbits Rabbits 1861) Manganese-phosphate reactions in aqueous systems and the effects of applications of monocalcium phosphate on the availablity of trimanganese manganese to oats in an alkaline fen bis(orthophosphate) 33 14154-09-7 Heintze SG 1968 soil Plant and Soil XXIX, no. 3 Manganese Massa W, Yakubovich OV A novel modification of manganese orthophosphate 33 14154-09-7 and Dimitrova OV 2005 orthophosphate Mn3(PO4)2 N/A Solid State Sciences, 7: 950-956

Nasal toxicity of manganese sulphate and manganese phosphate in young manganese phosphate male rats following subchronic (13 (hureaulite) (MMangP) 34 18718-07-5 Dorman D.C. Et al 2004(a) week) inhalation exposure rats inhalation toxicology 16(6): 481-488

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested manganese phosphate (hureaulite) (MMangP) 34 18718-07-5 Dorman DC et al 2004(b) 30 and 90 day inhalation exposure rats Assessment of bioaccumulation, neuropathy, and neurobehavious following subchronic (90 days) manganese phosphate inhalation in Sprague-Dawley rats Toxicology and applied pharmacology 183: (hureaulite) (MMangP) 34 18718-07-5 Normandin L. et al 2002 exposed to manganese phosphate Rats 135-145 manganese phosphate (hureaulite) (MMangP) 34 18718-07-5 Viteralla D 2000 5 and 7 week inhalation exposure rats

Diffraction patterns and solubility Manganese phosphate products of several divalent (MMangP) 34 18718-07-5 Boyle FW and Lindsay WL 1985 manganese phosphate compounds. N/A Soil Sci Soc Am J. 49(3): 761-766 Manganese phosphate Manganese phosphate equilibrium (MMangP) 34 18718-07-5 Boyle FW and Lindsay WL 1986 relationships in soils. SOIL Soil Sci Soc Am J. 50(3): 588- Preparation, x-ray diffraction pattern manganese III phosphate and solubility product of manganese (MMangP) 34 18718-07-5 Boyle FW and Lindsay WL 1985 (III) phosphate hydrate. N/A Soil Sci Soc Am J. 49: 758-760

Manganese phosphate (hereaulite) Mn5(PO4)2[PO3(OH)]2.4H Physical and Chemical 2O TESTED AS PART OF Characterization of Mn A MIXTURE CONTAINING Linda A. Beaupre, Fariba Phosphate/Sulfate Mixture Used in MANGANESE SULPHATE 34 18718-07-5 Salehi, Joseph Zayed 2004 an Inhalation Toxicology Study n/a Inhalation Toxicology, 16:231–244, 2004 Glutamate/Aspartate Transporter (GLAST), Taurine Transporter and Matallothionein mRNA Levels are differentially altered in astrocytes exposed to manganese chlroide, Cell cultures manganese phosphate' Erikson KM, Shuber RL , manganese phosphate or derived from rat (MnPO4) 34 18718-07-5 Aschner M 2002 manganese sulphate. brains NeuroToxicology 23 281-288

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Manganese phosphate Fariba Salehi, Daniel Bioaccumulation and locomotor (hereaulite) Krewski, Donna Mergler, effects of manganese Mn5(PO4)2[PO3(OH)]2.4H Louise Normandin, phosphate/sulfate 2O TESTED AS PART OF Greg Kennedy,Suzanne mixture in Sprague-Dawley rats A MIXTURE CONTAINING Philippe, and Joseph following subchronic (90 days) Toxicology and Applied Pharmacology 191 MANGANESE SULPHATE 34 18718-07-5 Zayeda, 2003 inhalation exposure Rat (2003) 264–271

Manganese phosphate (hereaulite) Fariba Salehi, Louise Mn5(PO4)2[PO3(OH)]2.4H Normandin, Daniel Neuropathology, tremor and 2O TESTED AS PART OF Krewski, Greg Kennedy, electromyogram in rats exposed to A MIXTURE CONTAINING Suzanne Philippe and manganese phosphate/sulfate MANGANESE SULPHATE 34 18718-07-5 Joseph Zayed 2006 mixture Rat J. Appl. Toxicol. 2006; 26: 419–426 manganese phosphate' Manganese-Phosphate Solubility (MnPO4) 34 18718-07-5 A. P. Schwab 1989 Relationships in an Acid Soil n/a Soil Sci. Soc. Am. J. 53:1654-1660 (1989). Bouchard MF, Sauve S, Beabeau B, Lengrand M, Brodeur ME, Bouffard T, Intellectual impairment in school-age manganese from all Limoges E, Bellinger DC children exposed to manganese from Environmental Health Perspectives. 119(1) sources 34 n/a and Mergler D drinking water Children 138-143 Manganese oxide, Manganese sulphate, Trimanganese tetraoxide, Dorman DC, Struve MF, Application of pharmacokinetic data Manganese phosphate Clewell HJ III and Anderson to the risk assessment of inhaled (hureaulite) (MMangP) 34 18718-07-5 ME 2006 manganese Rat, human NeuroToxicity, 27: 752-764 Dorman DC, Struve MF, Tissue manganese concentrations in Marshall MW, Parkinson young male rhesus monkeys Manganese phosphate CU, James RA, and Wong following subchronic manganese (hureaulite) (MMangP) 34 18718-07-5 BA 2006 sulfate inhalation Monkey Toxicological Sciences, 92(1): 201-210 Old age and gender influence the Dorman DC, McManus BE, pharmacokinetics of inhaled Manganese phosphate Marshall MW, James RA manganese sulfate and manganese Toxicology and Applied Pharmacology, 197: (hureaulite) (MMangP) 34 18718-07-5 and Struve MF 2004 phosphate in rats Rat 113-124

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Manganese phosphate (hureaulite) (MMangP) - Gerault Y, Riou A and Phosphate hydrogénophosphate Mn5(HPO4)2(PO4)2.4H2O 34 18718-07-5 Cudennec Y 1987 hydrate de manganèse N/A Acta Cryst. C43: 1829-1830

Manganese phosphate (hureaulite) (MMangP) - Huréaulite Mn5(HPO4)2(PO4)2.4H2O 34 18718-07-5 Unknown 2005? Mn52+(HPO4)2(PO4)2.4H2O N/A Handbook of Mineralogy Manganese phosphate (hureaulite) (MMangP) - (Mn,Fe)5(PO4)2(HPO4)2.4 http://www.mindat.org/min-1952.html H2O 34 18718-07-5 Unknown ? Hureaulite N/A [accessed 21 Oct 2011] Hureaulite - Hureaulite, Mn52+(H2O)4[PO3(OH)]2[ Mn52+(H2O)4[PO3(OH)]2[PO4]2: Its PO4]2 34 18718-07-5 Moore PB and Takahuru A 1973 atomic arrangement N/A American Mineralogist, 58: 302-307

Normandin L, Beaupré, Manganese distribution in the brain Manganese phosphate Salehi F, St-Pierre A, and neurobehavioural changes (hureaulite) Kennedy G, Mergler D, following inhalation exposure of rats Mn5(PO4)2(PO3(OH))2.4H Butterworth RF, Philippe S to three chemical forms of 2O, 34 18718-07-5 and Zayed J 2004 manganese Rat NeuroToxicology, 25: 433-441 Manganese phosphate (hureaulite) Direct effects of manganese Mn5(PO4)2(PO3(OH))2.4H Sistrunk SC, Ross MK and compounds on dopamine and its Environmental Toxicology and Pharmacology, 2O 34 18718-07-5 Filipov NM 2007 metabolite Dopac: an in vitro study Rat 23: 286-296 Das ternare system manganophosphate-phosphorsaure- manganese hydrogen wasser und die phosphate (DMangP) 35 51349-94-1 Grube G and Staesche M 1927 diphosphatomanganosaure. N/A Z Physik Chem. 13:572-583 Diffraction Patterns and Solubility Products of Several Divalent manganese hydrogen F. W. BOYLE, JR., AND Manganese Phosphate phosphate 35 51349-94-1 W. L. LiNDSAY 1985 Compounds n/a SOIL SCI. SOC. AM. J., VOL. 49, PG761-767 manganese hydrogen F. W. BOYLE, JR., AND Manganese Phosphate Equilibrium phosphate 35 51349-94-1 W. L. LINDSAY 1986 Relationships in Soils n/a SOIL SCI. SOC. AM. J., VOL. 50,

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David C. Dorman; Karrie A. Brenneman; Anna M. OLFACTORY TRANSPORT: A McElveen; Sean E. Lynch; DIRECT ROUTE OF DELIVERY OF manganese hydrogen Kay C. Roberts; Brian A. INHALED MANGANESE Journal of Toxicology and Environmental phosphate 35 51349-94-1 Wong 2002 PHOSPHATE TO THE RAT BRAIN rat Health, Part A, 65: 20, 1493 — 1511 tricopper Laha D, Bhattacharya D, Evaluation of copper iodide and bis(orthophosphate) Pramanik A, Santra CR, copper phosphate nanoparticles for [NANO] 36 7798-23-4 Pramanik P & Karmakar P 2012 their potential cytotoxic effect cells Toxicol. Res., 2012, 1, 131

Chimie minerale - sur les dicopper hydroxide orthohposphates du cuivre. Etude du phosphate (CuHP) 38 12158-74-6 Huerin H and Kozicki H 1952 systeme P2O5-Ocu-OH2 a 60 et 18° N/A Compt Rend 235: 52-1952 aluminium phosphate Article: Dale JC and King EJ. Acute Archives of Industrial Hygiene and (MALP) 39 13530-50-2 Drinker P 1953 toxicity of mineral dusts. mice Occupational Medicine Vol 7: 478-483

Screening of environmental chemical Aluminium orthophosphate Kada T, Hirano K and mutagens by the Rec-Assay system (TALP) 40 7785-30-7 Shirasu Y 1980 with Bacillus subtilis bacteria Chem Mutagens. 6:149-173

Aluminium orthophosphate Kanematsu N, Hara M and Rec assay and mutagenicity studies (TALP) 40 7785-30-7 Kada T 1980 on metal compounds bacteria Mutation Research .77:109-116

Mineral metabolism of rats fed Aluminium phosphate Greger JL, Bula EN and moderate levels of various aluminium (TALP) 40 7784-30-7 Gum ET 1985 compounds for short periods of time. Rat J. Nutr. 115:1708-1716 Aluminium orthophosphate Brosheer JC, Lenfesty FA Solubility in the system aluminium (TALP) 40 7785-30-7 and Anderson JF 1954 phosphate-phosphoric acid-water N/A J Am Chem Soc. 76:5951-5956

Aluminium orthophosphate Chimie minerale - sur les phosphates (TALP) 40 7784-30-7 Guerin H and Martin R 1952 d'aluminium N/A Compt Rend. 234:1777-9 Aluminium compounds, Review of Aluminium orthophosphate Toxicological Literature Abridged (TALP) 40 7785-30-7 Masten S 2000 Final Report Some human The crystal structure of aluminium Aluminium orthophosphate phosphate and gallium phosphate, (TALP) 40 7785-30-7 Mooney RCL 1956 low-cristobalite type N/A Acta Cryst. 9: 728

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Studies of the preparation and physical properties of multivalent metal condensed phosphates. V. The Aluminium orthophosphate Tsuhako M , Motooka I and grinding of various aluminium Bulletin of the Chemical Society of Japan. 46: (TALP) 40 7785-30-7 Kobayashi M 1973 phosphates. n/a 2343-2346 Yayt BB et al COULD NOT Aluminium orthophosphate BE Experimental and Clinical Pharmacology. 62: (TALP) 40 7785-30-7 1999 62: 37-39 TRANSLATED 37-39

Why aluminium phosphate is less Journal of the American College of Nutrition, Al(OH)3, AlPO4, Al 40 7784-30-7 Berthon G and Daydé SD 1992 toxic than aluminium hydroxide 11(3): 340-348 Studies of the preparation and physical properties of multivalent metal condensed phosphates. XI. Tsuhako M , Hasegawa K, The preparation of various aluminium Aluminium Matsuo T, Motooka I and phosphates and their thermal Bulletin of the Chemical Society of Japan. tripolyphosphate 41 13939-25-8 Kobayashi M 1975 transformation N/A 48(6): 1830-1835

Aluminium metaphosphate 42 13776-88-0 Van Der Meer H 1976 Acta Cryst. B25: 2423-2426 n/a Acta Cryst. B25: 2423-2426 a six month dietary toxicity study of sodium aluminium acidic sodium aluminium phosphate phosphate (SALP) 43 7785-88-8 Katz A.C. Et al 1984 in beagle dogs dogs (beagle) Fd. Chem. Toxic. 22(1): 7-9 Mutagenic evaluation of compound. sodium aluminium FDA 75-1. 007785-88-8, sodium S. typhimuium, phosphate (SALP, acidic, aluminium phosphate (acidic) F.C.C. Saccharomyces levair) 43 7785-88-8 Brusick D 1975 grade levair cerevisiae Litton Bionetics Inc. NTIS PB254520 Environmental Geochemistry and Health , ISSN sodium aluminium Twenty-six week toxicity study with 0269-4042 (Print) 1573-2983 (Online), 12 ( 1- phosphate (SALP) 43 7785-88-8 Pettersen J.C. Et al 1990 KASAL in beagle dogs dogs 2): 121-123

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Basic Sodium Aluminium Phosphates (SALP); KASAL and KASAL II. These are autogenous mixtures of alkaline sodium aluminium phosphate and dibasic sodium phosphate. Toxicity and Aluminium KASAL contains approx concentration in bone following 6% Al and KASAL II dietary administration of two sodium contains approx 13% Al. aluminium phosphate formulations in 43 7785-88-8 Hicks JS et al 1987 rat. rat Fd chem toxic, 25(7): 533-538

Aluminium bioavailability from the approved food additive leavening agent acidic sodium aluminium sodium aluminium Yokel R.A. And Florence phosphate, incorporated into a baked phosphate (SALP) 43 7785-88-8 R.L. 2006 good, is lower than from water Rats Toxicology 227: 86–93

Acidic sodium aluminium phosphate (SALP) 43 7785-88-8 Yokel RA 2005 Al bioavail ability from food N/A Toxicol Sci 84(1-S): 230-1 Aluminum bioavailability from basic sodium aluminum phosphate, an sodium aluminium Yokel RA, Hicks CL, approved food additive emulsifying Food Chem Toxicol. 2008 June ; 46(6): phosphate (SALP) 43 7785-88-8 Florence RL 2008 agent, incorporated in cheese rat 2261–2266. Sodium aluminium phosphate(acidic sodium aluminium and basic)(WHO food additives phosphate (SALP) 43 7785-88-8 WHO series 1) mouse

Statement on the evaluation of a new SALP acidic and SALP study related to the bioavailability of basic 43 7785-88-8 EFSA 2011 aluminium in food The EFSA Journal, 9(5): 2157 Formulation, synthesis and characterization of boron phosphate (BPO4) compounds as raw materials Abat M, Degryse F, Baird R to develop slow-release boron boron orthophosphate 44 13308-51-5 & McLaughlin MJ 2014 fertilizers n/a J. Plant Nutr. Soil Sci. 2014, 000, 1–9

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Initial submission: A two year inhalation toxicity study of calcium sodium calcium sodium metaphosphate fiber in the Biodynamics Inc. Project No. 85-7802. polyphosphate 45 23209-59-8 Anon 1990 rat. rat Monsanto Document Id No. 88-920005007. dehydroxylation mechanisms of sodium calcium Gomez F, Vast P, Llewellyn polyphosphate glasses in relation to polyphosphate 45 23209-59-8 P and Rouquerol F 1997 temperature and pressure. n/a Journal of non-Crystalline Solid. 222: 414-421 Toxicity of calcium sodium metaphosphate fibre. In vitro and in calcium sodium vivo degradation and clearance metaphosphate (CSM) 45 23209-59-8 Nair R.S. Et al 1992 studies Rats fundamental and applied tox. 19: 69-78 sodium calcium Low fibrosarcoma incidence seen for polyphosphate 45 23209-59-8 Unknown author 1986 phosphate fiber test. rat Pesticide and Toxic Chemical News. 8 research in mammals with sodium potassium radioactive high polymers phosphate tripolyphosphate (SKTP) 46 24315-83-1 Gotte H. 1953 markers dogs z naturforsch 8(b):173 Mutagenicity of cosmetics ingredients disodium fluorophosphate Gocke E, King MT, licensed by the European (SFP) 47 10163-15-2 Eckhardt K and Wild D 1981 Communities. Mutation Research. 90: 91-109. Micronucleus tests in mice on 39 disodium fluorophosphate Hayashi M, Kishi M, Sofuni food additives and eight (SFP) 47 10163-15-2 T and Ishidate M 1988 miscellaneous chemicals. Mouse Fd Chem. Toxic. 26(6): 487-500. Chronic toxicity of dietary sodium monofluorophosphate in growing disodium fluorophosphate rats, with special reference to kidney Acta path. Et microbiol. Scandinav. 65:493- (SFP) 47 10163-15-2 Poulsen H & Ericsson Y 1965 changes rat 504 Buchi R. Induced dominant lethal mutation and cytotoxic effects in germ cells of drosophila melanogaster with disodium fluorophosphate trenimon, PDMT and sodium d. (SFP) 47 10163-15-2 1977 monofluorophosphate. melanogaster Gentae genetics,87: 67-81 disodium fluorophosphate LD50 in the mouse compared to the (SFP) 47 10163-15-2 Lim J.K. Et al 1978 rat mice and rats Caries Res. 12: 177-179

preliminary studies of the caries disodium fluorophosphate inhibiting potential and acute toxicity (SFP) 47 10163-15-2 Shourie K.L. Et al 1950 of sodium monofluorophosphate hamster J. D. Res 29: 529

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Acute oral toxicity of sodium fluoride disodium fluorophosphate Whitford GM, Birdsong- and monofluorophosphate separately (SFP) 47 10163-15-2 Whitford NL and Finidori C 1990 or in combination in rats. rat Caries Res. 24: 121-126 induced dominant lethal mutations disodium fluorophosphate and cytotoxic effects in germ cells of Drosophila (SFP) 47 10163-15-2 Buchi R. 1977 Drosophila melanogaster melanogaster gentae Genetics 87(): 67 The distribution in the mammal body disodium fluorophosphate Ericsson Y and of F18 and P32 from double-labelled (SFP) 47 10163-15-2 Hammarstrom L 1965 Na2PO3F rats and mice Acta physiol. Scand. 65:126-137 Absorption and metabolism of the PO3F ion in the animal body. Studies disodium fluorophosphate Ericsson Y, Santesson G with F18, P32-labelled sodium Arch. Oral Biol. Special Supplement. 4:160- (SFP) 47 10163-15-2 and Ullberg S 1961 monofluorophosphate. 174. disodium fluorophosphate Gruninger SE, Clayton R, Acute oral toxicity of dentrifrice (SFP) 47 10163-15-2 Chang SB and Siew C 1988 fluorides in rats and mice. rats, mice J Dent Res. 67:884 Short-term feeding studies on sodium fluorophosphate (Na2PO3F) Atomic Enery Project Rep. UR-200. Q. Tech. disodium fluorophosphate Maynard EA and Downs and potassium hexafluorophosphate rep. US atomic energy commision . Univ (SFP) 47 10163-15-2 WL 1951 (KPF6) in rats rat Rochester Oct 1-Dec 33: 24-26 Fluorine storage in rats receiving disodium fluorophosphate Muhler JC, Weddle DA, different flourines in the drinking (SFP) 47 10163-15-2 Stewart JO 1955 water at varying pH rat J. Dent. Res. 34:895-899 Incorporation of fluoride in bones and teeth and dental fluorosis in mice disodium fluorophosphate Ruzicka JA, Mrklaus L and after administration of complex (SFP) 47 10163-15-2 Rokytova K 1974 fluorides mice Archs oral Biol. 19: 947-950 Chemical stability and mode of disodium fluorophosphate gastrointestinal absorotion of sodium (SFP) 47 10163-15-2 Setnikar I and Arigoni R 1988 monoflurophosphate. Arzneim Forsch. 38(1): 45-49 Caries Res. 17 (Suppl. 1): 36-45 in: Karger S (1983) Monofluorophosphate perspectives. Caries Research. Journal of the European disodium fluorophosphate Smith FA and Hodge HC Organisation for Caries Research. (Filename: (SFP) 47 10163-15-2 (most important article) 1983 Toxicology of monoflurophosphate. various Nijmegen caries research) disodium fluorophosphate Smith FA, Downs WL, Screening of fluorine-containing (SFP) 47 10163-15-2 Hodge HC & Maynard EA 1960 compounds for acute toxicity mice Toxicity and Applied Pharmacology. 2 : 54-58 Toxicity of fluoride-containing dental sodium fluorophosphate 47 10163-15-2 Smith GE 1985 preparations: a review. various The science of the total environment. 43:41-61

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Absorption of various fluorine disodium fluorophosphate compounds from the gastrointestinal (SFP) 47 10163-15-2 Zipkin I & Likins RC 1957 tract of the rat rat Am J Physiol. 191: 547-550 Fluoride exposure and bone status in Sodium patients with chronic intestinal failure monofluorophosphate who are receiving home parenteral (SFP) 47 10163-15-2 Boulétreau PH et al 2006 nutrition. human Am J Clin Nutr 83:1429-1437 Laboratory Studies Concerning the Effectiveness and Safety of Various disodium fluorophosphate Stookey G.K., Hudson J.T. Fluoride and Fluoride-Phosphate (SFP) 47 10163-15-2 and Muhler J.C. 1967 Systems. human, rat J. Dent. Res., 46(3): 503-513 sodium fluorophosphate Inorganic fluorides used in drinking (SFP) 47 10163-15-2 WHO 1982 water and dental preparations N/A Complex fluorides: caries reduction disodium fluorophosphate and fluorine retention in the bones (SFP) 47 10163-15-2 Zipkin I & McClure FJ 1951 and teeth of white rats rat Public Health Reports. 66(47): 1523-1532 Clinical Trial of a Combined MFP- sodioum NaF Dentifrice Formulated at monoflurophosphate 47 10163-15-2 Ripa LW & Leske GS 1985 Different Concentrations Human NTIS disodium fluorophosphate Baylink DJ, Duane PB, Monophosphate physiology: the (SFP) 47 10163-15-2 Farley SM & Farley JR 1983 effects of fluoride on bone bones Caries Research. 17(1): 56-57 Effect of sodium monophosphate and disodium fluorophosphate calcium on bone density and fracture (SFP) 47 10163-15-2 Broll H, Peichi P, Wlifert H 1990 rate in osteoporosis n/a Lancet. 8: 1446-1447 Histological differences in bones of rats treated with sodium fluoride (NaF) and sodium disodium fluorophosphate Brun LR, Roma SM, Perez monofluorophosphate (MFP) (SFP), sodium fluoride 47 10163-15-2 F & Rigalli A 2009 rat Bone

Delmas PD, Dupuis J, Treatment of Vertebral Osteoporosis disodium fluorophosphate DuBoeuf F, Chapuy MC & with Disodium Monofluorophosphate: Journal of bone and mineral research. 5(1). (SFP), sodium fluoride 47 10163-15-2 Meunier PJ 1990 Comparison with Sodium Fluoride human 143-147 disodium fluorophosphate (SFP) 47 10163-15-2 Ericsson Y 1967 Biological splitting of PO3F ions N/A Caries Research. 1: 144-152 Bone morphometry and differences in bone fluorine containing disodium fluorophosphate compounds in rats treated with NaF (SFP), sodium fluoride 47 10163-15-2 Brun LR, Pera LI & Rigalli 2010 and MFP Rat Biomedicine & Pharmacotherapy (64)1-6

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Caries Research: Monofluorophosphate Perspectives. disodium fluorophosphate The compound and its past, present (SFP) 47 10163-15-2 Gron P and Ericsson Y 1983 and future applications. various Caries Research. Vol 17, supplement 1 disodium fluorophosphate Reaction of monofluorophosphate (SFP) 47 10163-15-2 Duff EJ 1983 with apatitic substrates N/A Caries Research 17(1):77-90 disodium fluorophosphate Monofluorophosphate physiology: (SFP) 47 10163-15-2 Ericsson Y 1983 General Considerations various Caries Research 17(1): 46-55 Comparisons of serum fluoride levels after administration of monofluorophosphate-calcium Erlacher L, Teufelsbauer H, carbonate or sodium fluoride: disodium fluorophosphate Bernecker P, Pietschmann differences in peak serum (SFP) 47 10163-15-2 P & Weissel M 1993 concentrations. Human Clinical Investigations. 72: 1082-1085 The effect of sodium Gedalia I, Hodge HC, monofluorophosphate and sodium disodium fluorophosphate Anaise J, White WE & fluoride on bone immobilization in (SFP) 47 10163-15-2 Menczel J 1970 rats rat Calc. Tiss. Res. 5, 146-152 disodium fluorophosphate Fluoride and monofluorophosphate (SFP) 47 10163-15-2 Lindahl CB 1983 analysis N/A Caries Research. 17(1): 9-20 monofluorophosphate utilisation in disodium fluorophosphate oral preparations: laboratory (SFP) 47 10163-15-2 Melberg JR 1983 observations cells Caries Research. 17(1):102-118 disodium fluorophosphate biochemistry of (SFP) 47 10163-15-2 Pearce EIF 1983 monofluorophosphate n/a Caries Research. 17(1): 21-35 treatment of postmenopausal oseoporosis with sodium monofluorophosphate: preliminary disodium fluorophosphate results of a long-term double blind proceedings of the forth international (SFP) 47 10163-15-2 Reginster JY 1993 placebo-controlled study Human symposium on oseoporosis . 452-7 Therapeutic experience with the disodium fluorophosphate combination monofluorophosphate proceedings of the forth international (SFP) 47 10163-15-2 Ringe JD, Schmidt R 1993 and calcium Human symposium on oseoporosis . 433-434 disodium fluorophosphate Interaction of monofluorophosphate (SFP) 47 10163-15-2 Rolla G 1983 with plaque and saliva Human Caries Research . 17(1): 91-101 disodium fluorophosphate (SFP) 47 10163-15-2 Smith FA & Hodge HC 1985 Toxicology of monoflurophosphate. rats Caries Research. 17(1): 36-45

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested disodium fluorophosphate (SFP) 47 10163-15-2 White WE 1983 monofluorophosphate - its beginning n/a Caries Research. 17(1): 2-8 Studies on the hydrolysis and disodium fluorophosphate absorption of monofluorophosphate Pharmacology and Therapeutics in denistry. 5: (SFP) 47 10163-15-2 Ericsson Y & Patterson C 1980 ions rats , humans 47-54 The mechanism of the disodium fluorophosphate monofluorophosphate action on n/a - human (SFP) 47 10163-15-2 Ericsson Y 1973 hydroxyapatite and dental enamel teeth Acta Odont Scand. 21:341-358 Metabolism of the complex disodium fluorophosphate Esteban L, Rigalli A & monofluorophosphate-alpha2- (SFP) 47 10163-15-2 Puche C 1999 macroglobulin in the rat rat Medicina. 59:15-156 monofluorophosphate is hydrolysed by alkaline phosphatase and mimics disodium fluorophosphate Farley JR, Tarbaux NM, the actions of NaF on skeletal n/a - in vitro (SFP) 47 10163-15-2 Lau KHW &Baylink DJ 1987 tissues, In vitro study Calcified Tissue International. 40:35-42 Glass RL, Peterson JK, Fluoride ingestion resulting from the disodium fluorophosphate Zuckerberg DA & Naylor use of a monofluorophosphate (SFP) 47 10163-15-2 MN 1975 dentrifice by children human British Dental Journal. 138:423-426 Preliminary investigations of the effect of sodium monofluorophosphate on salivary disodium fluorophosphate Haydon GB, Hein JW & acid production and hydroxy apatite (SFP) 47 10163-15-2 Gardner DE 1951 solubility n/a J Dent Res. 30:466 Muller P, Schmid K, Sodium fluoride-induced gastric disodium fluorophosphate Warnecke G, Setnikar I & mucosal lesions: comparison with (SFP) 47 10163-15-2 Simon B 1992 sodium monofluorophosphate Human Z Gastroenterol. 30:252-254 The effect of sodium fluoride and sodium monofluorophosphate on the disodium fluorophosphate Nordenberg D, Simkin A, mechanical properties of normal and (SFP) 47 10163-15-2 Gedalia I & Robin G 1971 osteoporotic rat bone. rat Isr J. Med. Sci . 7(3): 529-531 Bioavailability of Fluoride Administered as Sodium Fluoride or disodium fluorophosphate Rigalli A, Morosano M & Sodium Monofluorophosphate to Arzneim Forsch / Drug Research. 46(I): 531- (SFP) 47 10163-15-2 Puche RC 1996 Human Volunteers human 533 Gastric and Intestinal Absorption of disodium fluorophosphate Rigalli A, Cabrerizo A, Monofluorophosphate and Fluoride in (SFP) 47 10163-15-2 Beinlich AD & Puche RC 1994 the Rat rat Arzneim Forsch / Drug Research. 44: 651-655

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Comparative Study of the Effect ofSodium Fluoride and Sodium disodium fluorophosphate Rigalli A, Alloatti R, MonoJluorophosphate on Glucose (SFP) 47 10163-15-2 Menoyo I & Puche RC 1995 Homeostasis in the Rat rat Arzneimittelforschung. 45(3): 298-292 disodium fluorophosphate Rigalli A, Esteban L, Pera L Binding of Monofluorophosphate to (SFP) 47 10163-15-2 & Puche RC 1997 alpha2-Macroglobulin and C3 n/a Calcified tissue international. 60:86-89 In postmenopausal osteoporosis the Rigalli A, Pera L, Morosano bone increasing effect of disodium fluorophosphate M, Masoni A, Bocanera R, monofluorophosphate is not (SFP) 47 10163-15-2 Tozzini T & Puche RC 1999 dependent on serum fluoride human Medicina. 59:157-161 Pharmacokinetic Differences between Sodium Fluoride and Sodium Monofluorophosphate and Rigalli A, Ballina JC, Comparative Bone Mass Increasing disodium fluorophosphate Beinlich AD, Alloatti R & Activity of Both Compounds in the (SFP) 47 10163-15-2 Puche RC 1994 Rat rat Arzneim Forsch/Drug Res. 44(I).6:762766 Monofluorophosphate Increases Serbet JL, Richard P, Lumbar Bone Density in Osteopenic disodium fluorophosphate Mennecier I, Bisset JP & Patients: A Double-Masked (SFP) 47 10163-15-2 Loeb G 1995 Randomized Study human Osteoporosis Int 5:108-114

Van Asten P, Darroudi F, Cytogenetic effects on lymphocytes disodium fluorophosphate Natarajan AT, Terpstra IJ & in osteoporotic patients on long-term (SFP) 47 10163-15-2 Duursma SA 1998 fluoride therapy human cells Pharm World Sci. 20: 314-318

Fluoride Bioavailability from disodium fluorophosphate Villa A, Guerrero S, Disodium Monofluorophosphate (SFP) 47 10163-15-2 Cisternas P & Mockeberg F 1989 Fluoridated Milk in Children and Rats human, rats Caries Research. 23:179-183 disodium fluorophosphate Zeiger E, Shelby MD & Environmental and Molecular Mutagenesis (SFP) 47 10163-15-2 Witt KL 1993 Genetic toxicity of fluoride various 21:309-318 disodium fluorophosphate Clinical Studies of (SFP) 47 10163-15-2 DePaola PF 1983 Monofluorophosphate Dentifrices various Caries Res. 17 (1): 119-135 Intestinal absorption of disodium monofluorophosphate in the rat as disodium fluorophosphate Beinlich AD, Brun LRM, affected by concurrent administration (SFP) 47 10163-15-2 Rigalli A & Puche RC 2003 of calcium. rat ArzneimForschDrugRes. 53(8):584-589

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Influence of milk and food on fluoride disodium fluorophosphate bioavailability from NaF and (SFP) 47 10163-15-2 Trautner K & Einwag J 1989 Na2FPO3 in man. human Journal of Dental Research. 68: 72-77 Absolute bioavailability of fluoride Van Asten P, Duursma, from disodium monofluorophosphate disodium fluorophosphate Glerum JH, FFT Ververs, and enteric-coated sodium fluoride (SFP) 47 10163-15-2 Van Rijn HJM & Van Dijk A 1996 tablets human Wur J Clinical Pharmacol. 50: 321-326 The effect of calcium on disodium monofluorophosphate absorption disodium fluorophosphate Villa A, Carrasco G, from the gastrointestinal tract of the Research Communications in Clinical (SFP) 47 10163-15-2 Valenzuela A & Garrido A 1992 rat rat Pathology and Pharmacology. 77(3): 367-373 Effects of meal on the disodium fluorophosphate pharmacokinetics of fluoride from (SFP) 47 10163-15-2 Warneke G & Setnikar I 1993 oral monofluorophosphate human Arzneim-Forsch/Drug res. 43(I).5: 590-595 disodium fluorophosphate A Study of the Effects of Sodium (SFP) 47 10163-15-2 Sliwinski RA 1953 Monofluorophosphate Master's Theses. Paper 864. Hill WL, Faust GT and phosphoric acid 48 7664-38-2 Hendricks SB 1943 Polymorphism of phosphorus oxide, n/a J. Am. Chem. Soc., 65: 797-804. Absence of mutagenic activity of ames phosphoric acid 48 7664-38-2 Al-Ani F.Y., Al-Lami S.K. 1988 acidity regulators salmonella Mutation research, 206():467-470 Effect of different acids on the phosphoric acid 48 7664-38-2 Alkahem HF 1989 freshwater fish Aphanius dispar. fish J Biol Sci Res, 20(3): 537-545 Carbonated Beverage Consumption Phosphoric acid 48 7664-38-2 Amato D et al 2001 and Bone Fractures N/A Arch Pediatr Adolesc Med 155(2):200-201

Acute effects on soft drink intake on calcium and phosphate metabolism Phosphoric acid 48 7664-38-2 Amato D et al 1998 in immature and adult rats. rats Rev Invest Clin 50: 185-189

Toxic effects of two dental materials on human buccal epithelium in vitro human tissue phosphoric acid 48 7664-38-2 Arenholt-bindslev D. et al 1987 and monkey buccal mucosa in vivo cells scand j dent res 95: 467-474

the effect of a prolonged intake of phosphoric acid 48 7664-38-2 Bonting S.L. 1952 phosphoric acid and citric acid in rats Rats dissertation

Phosphoric acid 48 7664-38-2 Brown E.H and Whitt C.D. 1952 Vapour pressure of phosphoric acids. n/a Ind. Eng. Chem. 44,3:615-618 Agents and actions, vol 11, no 5, page 515 phosphoric acid 48 7664-38-2 Bucher K et al 1981 skin irritation potential mice onds

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Anals of Emergency Medicine, 16:8 August phosphoric acid 48 7664-38-2 Caravati M 1987 one acute human toxicity case report humans 1987, page 119/904 Handbook of Hazardous chemical phosphoric acid 48 7664-38-2 Cheremisinoff NP 2000 properties N/A N/A Blood phosphorus levels of laying hens at various time intervals after Phosphoric acid 48 7664-38-2 Choi JH et al 1979 dosing with phosphoric acid. hens J. Nutr. 109: 1515-1518 The phosphorus excretion pattern and balance during one egg cycle of the laying hen fed a phosphorus deficient diet with or without a signle Phosphoric acid 48 7664-38-2 Choi JH et al 1978 dose of phosphoric acid hens Unknown Journal Density of aqueous solutions of Christensen JH and Reed phosphoric acid. Measurements at Industrial and Engieneering chemistry. 47(6): phosphoric acid 48 7664-38-2 RB 25°C n/a 1277-1281 duck, rabbit, L'acide phosphorique. Son innocuite. horse, guinea- Sea principlaes indications en pig, dog, phosphoric acid 48 7664-38-2 Cadtru F 1904 therapeutique. human La Presse Medicale. 74 sea urchin sublethal pH decrease may cause (embryo and genetic damage to Eukaryotic Cell: A sperm) and study on Sea Urchins and Salmonella Teratogenesis, Carciogenesis and phosphoric acid 48 7664-38-2 Cipollaro. M. et al 1986 Salmonella typhimurium typhimurium Mutagenesis 6: 275-287 Demerec. M., Bertani G. a survey of chemicals for mutagenic American naturalist 85(821): 119-136 (see phosphoric acid 48 7664-38-2 and Flint J. 1951 action on E. Coli bacteria 123) Drahoslava Vyskocilova et phosphoric acid 48 7664-38-2 al 1983 workers IN RUSSIAN humans pracov lek, 35(2):76 effects of different acids on the Ellgaard E.G, Gilmore III bluegill sunfish, Lepomis phosphoric acid 48 7664-38-2 J.Y. 1984 macrochirus rafinesque fish j. Fish Biol. 25: 133-137 Chronic broncopneumopathy and pneumoconiosis in workers employed in phosphoric acid phosphoric acid 48 7664-38-2 Fabbri L. et al 1977 production human Lavoro Umano 27: 50-57 Phosphoric acid; toxic chemical release reporting; community right to phosphoric acid 48 7664-38-2 Federal register.55 1990 know n/a n/a

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threshold concentration of phosphorous acid 48 7664-38-2 Fedorencko vi et al 1991 phosporous acid in water ? unknown gig sanit 45():24 Consumption of soft drinks with phosphoric acid as a risk factor for the development of in Phosphoric acid 48 7664-38-2 Fernando GR et al 1999 postmenopausal women human J. Clin. Epidemiol. 52(10):1007-1010.

The effect of 50 per cent phosphoric phosphoric acid 48 7664-38-2 Forsberg C.M. 1982 acid on oral soft tissues Rats Swed Dent J Supplement 15 Cola beverage consumption induces bone mineralisation reduction in Phosphoric acid 48 7664-38-2 Garcia-Contreras F et al 2000 Ovariectomized rats. human Arch. Med. Res. 31:360-365. Harrison W N., Bradberry S Phosphoric acid UKPID monograph. Phosphoric acid UKPID monograph. IPCS phosphoric acid 48 7664-38-2 M and Vale J A n/a IPCS INTOX databank. n/a INTOX databank. Carbonated beverages and urinary Phosphoric acid 48 7664-38-2 Heaney RP et al 2001 calcium excretion. human Am. J. Clin. Nutr. 74:343-347. Some paradoxical effects in Experimental Medicine and Surgery.V (2- phosphoric acid 48 7664-38-2 Hermann 1947 experimental pharmacology. n/a 3):160-162. High production volume information rat, sheep, system(HPVIS). HPV phosphoric acid full dossier off rabbit, human, High production volume information phosphoric acid 48 7664-38-2 Phosphoric acid . n/a web 22-12-08 S. typhimurium, system(HPVIS). Phosphoric acid . The tolerence of rabbit cornea for Bulletin of The Johns Hopkins Hospital. Phosphoric acid 48 7664-38-2 Hughes W.F. 1948 various chemical substances. Appendix I. 82:338-349 cytotoxicity of phosphoric acid on hamster lungs phosphoric acid 48 7664-38-2 Iijima S. et al 1993 cultured mamalian cells cells shigaku (odontology) 80(5): 1159-1165 Measurement of the toxicity of micro phosphoric acid 48 7664-38-2 Ishii H. et al 1981 chemicals to the activated sludge organisms suishitsu Odaku Kenkyu 4(4 suppl): 197-203 Two dilutions of phosphoric acid Phosphoric acid 48 7664-38-2 Jacobs G.A 1988 tested on eye. J Am. Coll. Toxicol. 11,6:724 An objective method for the phosphoric acid 48 7664-38-2 Jacobs G.A., Martens M.A. 1989 evaluation of eye irritation in vivo rabbits Fd. Chem. Toxic. 27(4): 255-258 Polyphosphate metabolism in the Jacobson L. and Halmann blue-green alga Microcystis Phosphoric acid 48 7664-38-2 M. 1982 aeruginosa. algae Journal of Plankton Research. 4,3:481-488 1992, Phosphoric acid prepared at the 44th Phosphoric acid 48 7664-38-2 JECFA 1995 JECFA n/a Phosphoric acid prepared at the 44th JECFA

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Various mamals and phosphoric acid 48 7664-38-2 Kristensen P 1993 Inorgani c Acid Aerosols humans Nordic Arbete oche Halsa 1: 7-54 observations on the effect of chemical configuration on the edema- producing potency of acid, phosphoric acid 48 7664-38-2 Larson P.S. Et al 1956 aldehydes, ketones and alcohols rabbits j pharmac exp ther 116():119 Association between long-term consumption of soft drinks and variables of bone modeling and remodeling in a sample of healthy Phosphoric acid 48 7664-38-2 Libuda L 2008 German children and adolescents. human Am. J. Clin. Nutr. 88:1670-1677. The dermal irritancy/corrosion of 20 phosphoric acid 48 7664-38-2 Loden M. et al 1985 compounds in acqueous solutions Rabbits FAO rapport E 40023 ISSN 0281-9945 On phosphates and phosphoric acid as dietary factor in the calcium phosphoric acid 48 7664-38-2 Malm O J 1952 balance of man. human Unknown Journal phosphoric acid 48 7664-38-2 Malm OJ 1952 dietary balance calcium and P-acid humans Scand J Clin Lab Invest, 5, pages 75-84 Consumption of soft drinks with phosphoric acid as a risk factor for the development of hypocalcemia in Phosphoric acid 48 7664-38-2 Mazariegos-Ramos et al 1995 children: a case-control study. human The J. Pediatr. 126(6):940-942 Evaluation of the EPA exposure Regulatory toxicology and Pharmacology. 29: phosphoric acid 48 7664-38-2 Morley KM 1999 assessment for phosphoric acid. N/A 309-318 The toxic effect of some phosphate phosphoric acid 48 7664-38-2 MsMeniman N.P. 1973 supplements fed to sheep sheep Australian Veterinarian J. 49: 150-152 The first dissociation constant for phosphoric acid from 0 to 50°. Nims LF (1933)The second dissociation constant of phosphoric acid from 20 to 50° J Am Chem Soc 56: 1110-1112, J Am Chem Phosphoric acid 48 7664-38-2 Nims LF 1934 N/A Soc 55: 1946-1951 Structure and properties of the condensed phosphates condensed phosphoric Parks JR and Van Wazer –reorganization theory and some acids 48 7664-38-2 JR 1957 applications N/A J Am Chem Soc, 79: 4890-97

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Phosphoric acid, Phosphorous pentoxide, Phosphorous oxychloride, Payne MP, Shillaker RO Phosphorous pentachloride, phosphoric acid 48 7664-38-2 and Wilson AJ 1993 Phosphorous pentasulphide. various Toxicity Review 30. HSE Books. ABSTRACT : skin irritation tests on Randall D.J. And Robinson various concentrations of phosphoric phosphoric acid 48 7664-38-2 E.C. 1977 acid Rabbits monsanto phosphoric acid 48 7664-38-2 Reinl W 1956 toxicity IN G ERMAN Archiv fur Toxikologie, bd 16, S 158-181

Toxicological characteristics of phosphoric acid and some of its phosphoric acid ( and chromium salts used as a binder in Gig. Truda i Prof. Patol. v Tsv i Cher. various non -IP subs) 48 7664-38-2 Sigova N.V. 1983 refractory production. human , rat Metallurgii, M: 65-69 Handbook of toxic and hazardous chemicals. phosphoric acid ( and Handbook of toxic and hazardous Noyes Publications, Park Ridge, New Jersey, various non -IP subs) 48 7664-38-2 Sittig M. 1981 chemicals. n/a USA. Phosphoric Acid Volume I (Parts I & II) Marcel phosphoric acid 48 7664-38-2 Slack A.V. 1968 Phosphori c acid (book) n/a Dekker Inc, New York whole body exposures to a phosphoric acid : red phosphoric acids aerosol: 1. phosphorus/butyl rubber Spontaneous activity effects in wild http://aphis.usda.gov/wildlife_damage/nwrc/pu mixture 48 7664-38-2 Sterner RT 1993 rodent and avian species. birds, rodents blications/93pubs/9337.pdf Opinion of the scientific panel on dietetic products, Nutrition and allergies on a request from the The EFSA Journal 233.1- commission related to the tolerable phosphoric acid 48 7664-38-2 19 2005 upper intake level of phosphorus. rats The EFSA Journal 233.1-19

Colas, but not other carbonated beverages, are associated with low bone mineral density in older women: Phosphoric acid 48 7664-38-2 Tucker KL 2006 the Framingham Osteoporosis study. human Am. J. Clin. Nutr. 84:936-942. Urben PG (Ed), complied Bretherick's Handbook of reactive phosphoric acid 48 7664-38-2 by : Pitt MJ 1999 chemical hazards. 6th Ed - vol 1. N/A N/A

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Urben PG (Ed), complied Bretherick's Handbook of reactive phosphoric acid 48 7664-38-2 by : Pitt MJ 1999 chemical hazards. 6th Ed - vol 2. N/A N/A Vanderzee CE and Quist The third dissociation constant of Phosphoric acid 48 7664-38-2 AS 1961 orthophosphoric acid. N/A J Phys Chem 65: 118-123

on the sensitivity to low pH of some Von Brehm J. and selected crustaceans (Daphnia and phosphoric acid 48 7664-38-2 Meijering M.P.D 1982 Gammarus, Crustacea) Crustaceans Arch. Hydrobiol. 95(1): 17-27 Toxicology Update: Phosphoric Phoshphoric acid 48 7664-38-2 Von Burg R. 1992 acid/phosphates. various Journal of Applied Toxicology. 12(4) 301-203 ABSTRACT: Modified skin irritation study on 75% phosphoric acid in a phosphoric acid 48 7664-38-2 Weiner M. et al 1988 single rabbit rabbit ? Relationship between carbonated and other low nutrient dense beverages and bone mineral content Phosphoric acid 48 7664-38-2 Whiting SJ et al 2001 of adolescents human Nutr. Res. 21:1107-1115. phosphoric acid 48 7664-38-2 WHO 1964 WHO Food additives.24.65 human, rat WHO IPCS INCHEM phosphoric acid

Teenaged girls, carbonated beverage Phosphoric acid 48 7664-38-2 Wyshak G 2000 consumption and bone fractures human Arch. Pediatr. Adolesc. Med. 154:610-613 Toxicite comparee de divers acides phosphoric acid 48 7664-38-2 Guevelard F 1922 pour les poissons (Epinoches) fish CR Acad Sci. 175: 124-1242 Agentes acidulantes utilizados em phosphoric acid 48 7664-38-2 Nazario G 1952 alimentos ? Rev. Inst. Aldolpho, Lutz. 11: 141 orthophosphoric acid, On the difference in the poisonous pyrophosphoric acid, Gamgee A, Priestly J and activity of phosphorous in ortho-, metaphosphoric acid 48 7664-38-2 Larmuth L 1877 meta-, and pyro- phosphoric acids n/a Journal of Anatomy and Physiology. 11: 255 The influence of hydrogen ion concentration of the minimum dissolved oxygen toleration of the Townsend LD and Cheyne silver salmon, Oncorhynchus kisutch phosphoric acid 48 7664-38-2 H 1944 (walbum). fish Ecology. 25(4):461-466 H. R. CROOKSHANK, F. E. KEATING, EARL Effect of chemical and enzymatic BURNETT, J. H. JONES agents on the formation of urinary AND calculi in fattening steers phosphoric acid 48 R. E. DAVIS 1960 cows J Anim Sci 1960. 19:595-600.

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Corrosion of metals by phosphoric Industrial and Engineering Chemistry. (23)2. phosphoric acid 48 7664-38-2 Kosting PR and Heins C acid metals pg 140-150

Corrosion resistance of nickel- phosphoric acid 48 7664-38-2 Inco 1966 containing alloys in phosphoric acid n/a Corrosion Engieneering Bulletin. 4. 1-40 phosphoric acid 48 7664-38-2 Craig BD 1990 Handbook of Corrosion Data n/a n/a

A standard laboratory corrosion test phosphoric acid 48 7664-38-2 Ebling HF & Scheil MA 1951 for metals in phosphoric acid service n/a Transactions of the ASME. 975-987 Study of corrosion–erosion behaviour Guenbour A, Hajji MA, of stainless alloys in industrial phosphoric acid 48 7664-38-2 Jallouli EM and Bachir AB 2006 phosphoric acid medium n/a Applied Surface Science. 253: 2362-2366

Groves ND, Eisenbrown Corrosion of metals by weak acids Corrosion - National association of corrosion phosphoric acid 48 7664-38-2 CM & Sharfstein LR 1960 under heat transfer conditions n/a engineers. Vol 17. 173-176 phosphoric acid 48 7664-38-2 Multi Alloy n/a Lab corrosion data for stainless steel. n/a Multi-alloy Corrosion of types 316 and 317 Stainless steel by 75% and 85% corrosion - national association of corrosion phosphoric acid 48 7664-38-2 Morgan AR 1959 phosphoric acid n/a engineers. Vol 15: 351-354 The corrosion properties of chrominum-nickel-manganese Proceedings - American Society for testing phosphoric acid 48 7664-38-2 Renshaw WG & Lula RA 1956 austenitic stainless steels n/a and Materials. 52: 866 Corrosion and weldability studies on chromium-manganese austenitic corrosion - National Association of Corrosion phosphoric acid 48 7664-38-2 Warren D 1960 stainless steels n/a Engineers. 16: 101-112 Yaro AS, Wael RK & Reaction kinetics of corrosion of mild Journal of the University of Chemical phosphoric acid 48 7664-38-2 Khadom AA 2010 steel in phosphoric acid n/a Technology and Metallurgy. 45(4): 443-448 Elmore KL, Hatfield JD, dissociation of phosphoric acid The journal of physical chemistry . 69(10): phosphoric acid 48 7664-38-2 Dunn RL & Jones AD 1965 solutions at 25 °C n/a 3520-3525 Corrosion Handbook. Corrosive agents and their interaction with materials. Volume 3. hypochlorites, phosphoric acid 48 7664-38-2 Kreysa G and Shutze M phosphoric acid. n/a Handbook. ISBN: 3-527-31119-X

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Effect of dietary phosphoric acid supplementation on acid-base Fettman MJ, Coble JM, balance and mineral and bone phosphoric acid 48 7664-38-2 Hamar DW, Norrdin RW 1992 metabolism in adult cats cat Am J Vet Res, 53(11): 2125-2135 National Institute for Occupational Safety and 1985- Health, Registry of Toxic Effects of Chemical Phosphoric acid 48 7664-38-2 Sweet DV 1986 58663. Phosphoric Acid Substances, Volume 4 American Conference of Governmental Industrial Documentation of the Threshold Limit Values Phosphoric acid 48 7664-38-2 Hygienists 2001 Phosphoric acid and Biological Exposure Indices, 7th Ed

Aluminium speciation studies in biological fluids. Part 3. Quantitative investigation of aluminium-phosphate Daydé S, Filella M and complexes and assessment of their Orthophosphoric acid 48 7664-38-2 Berthon G 1990 potential significance in vivo Journal of Inorganic Biochemistry, 38: 241-259 Comparison of molasses-alfalfa silage and phosphoric acid-alfalfa Phosphoric acid 48 7664-38-2 King WA 1943 silage as feeds for the milking cow NJ Agricultural Experiment Station Bulletin 704 Comparison of molasses-oat silage and phosphoric acid-oat silage as Phosphoric acid 48 7664-38-2 King WA 1944 feeds for the milking cow NJ Agricultural Experiment Station Bulletin 708

Hygienic guide series: phosphoric American Industrial Hygiene Association Phosphoric acid 48 7664-38-2 Anon 1957 acid quarterly, 18(2): 175-176 Phosphorus, phosphoric acid, phosphorus US Office of Health and Summary review of health effects pentoxide, phosphorus Environmental Assessment associated with elemental inorganic chlorides 48 7785-88-8 (EPA) 1990 phosphorus compounds Various EPA/600/8-89-072 Ohio Agricultural Experiment Station Phosphoric acid and Technical Series, Bulletin No 5: various other phosphorus Phosphorus compounds in animal containing substances 48 7785-88-8 Forbes EB and Keith MH 1914 metabolism Wooster, Ohio, USA

Phosphoric acid 48 7785-88-8 US EPA 2011 Phosphoric acid; CASRN 7664-38-2 Integrated Risk Information System (IRIS)

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Phosphoric acid and various other phosphorus Phosphoric acid, phosphates and containing substances 48 7785-88-8 Waggaman WHM 1927 phosphatic fertilisers American Chemical Society

Phosphoric acid 48 7785-88-8 ACGIH 2001 Phosphoric acid n /a unknown

Hawkins DB, Demeter MJ Caustic ingestion: controversies in phosphoric acid 48 7664-38-2 & Barnett TE 1980 management. A review of 214 cases. human The laryngoscope. 90 Miller FP, Vandome AF, Phosphoric acid 48 7785-88-8 McBrewster J 2010 Acide phosphorique n/a Alphascript publishing - book

Some chemicals requiring special consideration when deciding whether to sample the particle, vapour, or Applied Occupational and Environmental Phosphoric acid 48 7785-88-8 Perez C, Soderholm SC 1991 both phases of an atmosphere n/a Hygiene, 6: 859 - 864 Intital Submission: eye irritation classification study with phosphoric Bullock C.H. & Kamienski acid in rabbits with cover letter dated NTIS OTS0545337, Stauffer Chemical phosphoric acid 48 7785-88-8 F.X. 1986 082892 Rabbit company Initial submission: toxicological NTIS OTS0545979, Stauffer Chemical investigation of phosphoric acid with company / Younger Labs. Project number Y- phosphoric acid 48 7785-88-8 Birch M.D. 1992 cover letter date 081392 Rat/rabbit 75-27

Jono S, McKee MD, Murry CE, Shioi A, Nishizawa Y, Mori K, Morii H & Giachelli Phosphate regulation of vascular H3PO4 48 7664-38-2 CM 2000 smooth muscle cell calcification N/A Circulation Research. 87: 1-8

Corrosion of high-alloy stainless Technical Research Centre of Finland, Phosphoric acid 48 7664-38-2 Varjonen O 1989 steels in the wet phosphoric acid N/A Research Reports 588. ISBN-951-38-3372-0.

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Effect of dietary organic acid mixture Jang HD, Yoo JS, Kim HJ, on growth performance, organ Shin SO, Hwang Y, Zhou weight, blood immunological TX, Chen YJ, Cho JH & parameter and intestinal villi Phosphoric acid 48 7664-38-2 Kim IH 2008 morphology in broilers Chicken Korean J Poult Sci. 35(1): 57-62

Tilsaetning af Fosforsyre eller Ammoniumklorid til Minkfoder i Juni Maned: Betydning for Urin pH og Danish Fur Breeders Research Center, Phosphoric acid 48 7664-38-2 Clausen TN 2000 Tilvaekst Mink Holstebro, Denmark. Annual Report: 55-57

Phosphoric acid as a phosphorus phosphoric acid 48 Mohamed WZ 1984 supplement for water buffaloes water buffalo MARDI Res. Bull. 12,2:266-271 Enviro Technical Information for Publications Section, Environmental Protection phosphoric acid 48 7446-38-2 Environment Canada 1985 Problem Spills: Phosphoric acid Various Service, Environment Canada Phosphoric acid storage and phosphoric acid 48 7446-38-2 Barber J.C 1974 containment at Fertilizer Plants n/a Journal unknwon

Procedures for the destruction of the foliage of peas, field beans, [Frühjahrsrübs] and spring oilseed rape and weeds by Takala, Mauri LLMarie, Phosphoric ??? before combine phosphoric acid 48 7446-38-2 Palkane, Myttaala 1978 harvesting [translated from German] n/a Source unknown Toxicity comparee de divers acids Phosphoric acid 48 7664-38-2 Gueylard F and Dutal MM 1922 pour les Poissons (Epinoches) C R Acad Sci 175: 143-1245 1922 Effects of reducted pH on three life Sunapee char Jagoe CH, Haines TA and stages of sunapee char salvelinus Salvelinus Phosphoric acid 48 7664-38-2 Frederick WK 1984 alpinus alpinus Bull Environ Contam Toxicol, 33: 430-438 Brook trout - Chronic effects of reduced pH on Salvelinus Phosphoric acid 48 7664-38-2 Mendendez R 1976 Brook Trout (Salvelinus fontinalis) fontinalis J. Fish. Res. Board Can 33L 118-123 pH restraints on Lettuce Fruit Phosphoric acid 48 7664-38-2 Reynolds T 1975 Germinaton Lettuce Amn. Bot. 39, 79-805 Phosphorus: An outline of its Phosphorus: an outline of its chemistry, chemistry, biochemistry and biochemistry an technology, Elsevier Scientific Phosphoric acid 48 7664-38-2 Corbridge DEC 1978 technology Publishing Company Edwards OW and Huffman Viscosity of aqueous solutions of Chemical and Engineering Data Series Vol. 3 Phosphoric acid 48 7664-38-2 EO 1958 phosphoric acid at 25°C No. 1 145-146

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Activity of orthophosphoric acid in Elmore KL, Mason CM and aqueous solution at 25°C from vapor Phosphoric acid 48 7664-38-2 Christensen JH 1948 pressure measurements Phosphoric acid 48 7664-38-2 Othmer K 2005 Phosphoric acid and phosphates Encyclopedia of Chemical Technology Poisoning: Toxicology, Symptoms and Treatments, Fourth Edition, Publisher Charles Phosphoric acid 48 7664-38-2 Arena JM 1979 C Thomas rabbit, rat, Acute inhalation toxicity of red mouse, guinea Phosphoric acid 48 7664-38-2 Ballantyne B 1998 phosphorus smoke pig Toxic Substance Mechanisms, 17:251-266 Liquid caustic ingestion: spectrum of injury (study based ion human Cello JP, Fogel RP, Boland patients who ingested liquid caustics Phosphoric acid 48 7664-38-2 CR accidentally) human Arch Intern Med 140: 501-504 Acute toxicological evaluation of Randall DJ and Robinson various concentrations of phosphoric Phosphoric acid 48 7664-38-2 CR 1976 acid rats Monsanto

A simple method for screening rat, mouse, Phosphoric acid 48 7664-38-2 Sekizawa J et al 1994 assessment of skin and eye irritation guinea pig Journal of Toxicolgical Sciences, 19: 25-35 Toxicological review of inorganic Phosphoric acid 48 7664-38-2 Weiner M. et al 2001 phosphates Food and Chemical Toxicology 39: 759-786

Yilmaz S, Unal F, DNA damage in human lymphocytes human Toxicology and Industrial Health Vol. 30(10) phosphoric acid 48 7664-38-2 Yuzbasioglu D & Celik M 2014 exposed to four food additives in vitro lymphocytes 926–937 An Updated Mortality Follow-Up Checkoway H, Heyer NJ & Study of Florida Phosphate Industry AMERICAN JOURNAL OF INDUSTRIAL phosphoric acid 48 7664-38-2 Demers PA 1996 Workers human MEDICINE 30:452-460 Cytotoxic effects of two acid solutions and 2.5% sodium hypochlorite used in endodontic n/a - human phosphoric acid 48 7664-38-2 Navarro-Escobar et al 2010 therapy teeth Med Oral Patol Oral Cir Bucal. 15 (1):e90-4.

Cytotoxicity of 45S5 bioglass paste used for dentine hypersensitivity n/a - human phosphoric acid 48 7664-38-2 Bakri et al 2011 treatment. teeth Journal of Dentistry. 39: 599-603

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Johnson RH, Christensen GJ, Stigers RW & Laswell Pupal irritation due to phosphoric n/a - human phosphoric acid 48 7664-38-2 HR 1970 acid component of silicate cement. teeth Oral Surgery. 29(3):447-454

Prado M, Da Silva JNL, Duque TM, Zaia AA, Ferraz Antimicrobial and cytotoxic effects of CCR, de Almeida JFA & de phosphoric acid solution compared to n/a - human phosphoric acid 48 7664-38-2 Almeida Gomes BPF 2014 other root canal irrigants. teeth Journal of Applied Oral Science. 23(2):158-163 n/a - human Phosphoric acid 48 7664-38-2 Ibsen RL & Neville K 1974 N/A teeth Adhesive Restorative Dentistry. Pg 45 (book)

Bactericidal activity of phosphoric acid, citric acid, and EDTA solutions Oral Surg Oral Med Oral Pathol Oral Radiol Phosphoric acid 48 7664-38-2 Arias-Moliz MT et al 2008 against Enterococcus faecalis bacteria Endod 2008;106:e84-e89 Richardson ML & Gangolli The dictionary of substances and The Royal Society of Chemistry. Vol 6. ISBN 0- Phosphoric acid 48 7664-38-2 S (Ed.) 1994 their effects n/a 85186-330-2 Bremner JM and Douglas Decomposition of urea phosphates in Urea phosphate 51 LA 1971 soils. Soil Sci Am J. 35:575-578 Evaluation of Urea-phosphate as a Perez CB, Warner RG and source of nitrogen and phosphorous Cows and Urea phosphate 51 Loosli JK 1967 for ruminants Lambs J Animal Science. 26: 810-819 investigation of cavity-sealing Zinc phosphate 52 13598-37-3 Trail JS and Sausen RE 1962 abilities of zinc phosphate n/a J D Res. 41(3):525-536 ammonium magnesium Journal of radioanalytical and nuclear phosphate (struvite) 56 7785-21-9 Aage HK, et al 1997 The solubility of struvite. N/A chemistry. 223(1-2):213-215. ammonium magnesium Bouropoulos NC and Spontaneous precipitation of struvite phosphate (struvite) 56 7785-21-9 Koutsoukos PG 2000 from aqueous solutions N/A Journal of Crystal Growth. 213: 381-388 ammonium magnesium Uber orthophosphate (struvite) 56 7785-21-9 Bube K 1910 magnesiumammonimphosphate N/A Z. Anal Chem ammonium magnesium Thermodynamics of struvite phosphate (struvite) 56 7785-21-9 Buchanan JR et al 1994 formation. N/A American Society of Engineers. 37(2): 617-621 Solubility product of magnesium ammonium magnesium ammonium phosphate hexahydrate phosphate (struvite) 56 7785-21-9 Burns JR and Finlayson B 1982 at various temperatures. N/A Journal of Urology. 128: 426-427 ammonium magnesium The decomposition of Struvite: phosphate (struvite) 56 7785-21-9 Ribbe PH 1969 further evidence N/A mineralogical magazine, 37(286): 290 ammonium magnesium Solubility of magnesium ammonium Industrial and engineering chemistry. 18(11): phosphate (struvite) 56 7785-21-9 Uncles RF et al 1946 phosphate hexahydrate N/A 699-702

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Struvite (MgNH4PO4.6H2O) ammonium magnesium solubility and its application to a phosphate (struvite) 56 7785-21-9 Webb KM and Ho GE 1992 piggery effluent problem. N/A Water Sci Tech. 26(9-11): 2229- 2232 ammonium magnesium phosphate (struvite) 56 7785-21-9 Whitaker A 1968 The decomposition of struvite N/A Mineralogical magazine. 36: 820-824 ammonium magnesium An improved computer model of phosphate (struvite) 56 7785-21-9 Wrigley TJ et al 1992 struvite solution chemistry N/A Talanta. 39(12): 1597-1603

Joint FAO/WHO expert committee on magnesium dihydrogen food additives. Seventy-sixth pyrophosphate 58 10058-44-3 FAO/WHO 2012 meeting. Geneva, 5-14 June 2012 n/a JECFA/76/SC Structural characterisation of silicon silicon orthophosphate 64 12037-47-7 Poojary DM 1993 orthophosphate n/a Inorg. Chim. Acta. 208: 23-29 Lansiedel R, Ma-Hock L, Hofmanm T, Wiemann M, Strauss V, Treumann S, Wohlleben W, Groters S, Application of short-term inhalation silicon orthophosphate - WienchK & Van studies to assess the inhalation nanoparticle 64 12037-47-7 Ravenzwaay B 2014 toxicity of nanomaterials Particle and Fibre Toxicology. 11:!6 Monocalcium phosphate, Sodium metaphosphate, Calcium metaphosphate Reactions of Metaphosphates in No organism, University Microfilms an Arbor Mich PhD 21, 9 7758-23-8 Donoso-Torres 1958 Soils tested in soil Thesis (No Mic 59-1192) trisodium phosphate anhydrous, sodium acid pyrophosphate, tetrasodium pyrophosphate, tripotassium phosphate, 4, 7, 14, monocalcium phosphate 21 7601-54-9 Parent R. 1990 ABSTRACT: no title Rabbits j am coll toxicol 1: 4: 48-49 Evaluation of phosphate toxicity in Cope's Gray Treefrog (Hyla sodium phosphate' ? ? Earl JE and Whiteman HH 2010 chrysoscelis) Tadpoles tadpoles Journal of Herpetology. 44(2): 201-208

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? ? ? ? 1938 ? N/A Zh Obschch Khim. 8:1230-1231 mg phosphates ? ? Belopolskii AP et al 1950 ? (Title i n Russian) N/A Zh Prikl Chim. 23: 823-36 Broadus AE, Magee JS, A detailed evaluation of oral Mallette LE, Horst RL, phosphate therapy in selected oral phosphate' - not Lang R, Jensen PS, patients with primary Journal of Clinical Endocrinology and specified ? n/a Gertner JM & Baron R 1983 hyperparathyroidism Human Metabolism. 56(5) Oral Sodium Phosphate Solution A Review of its Use as a Colorectal sodium phosphate' ? ? Curran MP & Plosker GL 2004 Cleanser human Drugs 2004; 64 (15): 1697-1714 Age as a predictor of Gumurdulu Y, Serin E, after oral Ozer B, Gokcel A & phosphosoda administration for Journal of Gastroenterology and Heptology. oral sodium phosphate' ? ? Boyacioglu S 2004 colon preparation human 19: 68-72

The Effect of Oral Sodium Phosphate Kurana A, McLean L, Drug Products on Renal Function in oral sodium phosphate' ? ? Atkinson S & Foulks CJ 2008 Adults Undergoing Bowel Endoscopy human Arch Intem Med. 2008;168(6):593-597 A Prospective Assessment of Renal Impairment After Preparation Korsten MA, Spungen AM, for Colonoscopy: Oral Sodium Rosman AR, Ancha HR, Phosphate Appears to Be Safe Post JB, Shaw S, Hunt KK, in Well-Hydrated Subjects with oral sodium phosphate' ? ? Williams R & Bauman WA 2010 Normal Renal Status human Dig Dis Sci (2010) 55:2021–2029 Acute Hyperphosphatemia Caused by Sodium Phosphate Enema in a Nir-Paz R, Choen R & Patient with Liver Dysfunction and oral sodium phosphate' ? ? Haviv YS 1999 Chronic Renal Failure human Renal Failure, 21(5), 541-544

Extreme hyperphosphatemia and Orias M, Mahnensmith RL, acute renal failure after a phospohrus- oral sodium phosphate' ? ? Perazella MA 1999 containing bowel regimen human American Journal of Nephrology. 19: 60-63

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Fatal hypocalcemic, hyperphosphatemic, metabolic acidosis following sequential Pitcher DE, Ford RS, sodium phosphate-based enema oral sodium phosphate' ? ? Nelson MT & Dickenson E 1997 administration human Gastrointestinal endoscopy. 46(3) Gonlusen G, Akgun H, Renal Failure and Nephrocalcinosis Ertan A, Olivero J & Truong Associated With Oral Sodium oral sodium phosphate' ? ? LD 2006 Phosphate Bowel Cleansing human Arch Pathol Lab Med. 2006;130:101-106)

Ahmed M, Raval P and Oral sodium phosphate catharsis and the American Journal of Gastroenterology. oral sodium phosphate' ? ? Bunganza G 1996 acute renal failure human 91(6): 1261-1262 Fatal Hypocalcemia From Phosphate Absorption From Laxative oral sodium phosphate' ? ? McConnell TH 1971 Preparation human JAMA, April 5, 1971 • Vol 216, No 1 Artefactual nanoparticle activation of Pele L, Haas CT, Hewitt R, the inflammasome platform: in vitro Nano apatitic calcium Faria N, Brown A & Powell evidence with a nanoformed Nanomedicine. Posted online on July 3, 2014. phosphate ? ? J 2014 calcium phosphate cells (doi:10.2217/nnm.14.58)

Metal complexing by phosphorus compounds. I. The thermodynamics of association of linear STPP 0, (11?), 7 7758-29-4 Irani R.R. and Callis C.F. 1960 polyphosphates with calcium. J. Phys. Chem. 64:1398-1407 The mechanism of the hydrolysis of condensed phosphates. I. The sodium tripolyphosphate, solvent effect on the hydrolysis of Bulletin of the Chemical society of Japan. sodium pyrophosphate 0, ? 7758-29-4, ? Watanabe M 1974 pyro- and tripolyphosphates N/A 47(8): 2048-2050 primary mutagenicity screening of bacteria food additives currently used in salmonella sodium tripolyphosphate 0, 10 13573-18-7 Ishidate M. et al 1984 Japan (ames test) Fd. Chem. Toxic. 22(8): 623-636 Inorganic phosphates in biology:structure, metabolism and STPP, SHMP, IMP 0, 10 ,11 7758-29-4 Harold FM 1966 function, Bacteriological Reviews: 772-794. STPP, sodium hexametaphosphate, Enzymatic degradation and tetrapotassium Davis E.M. And Wilcomb assimilation of condensed pyrophosphate 0, 10, 15 7758-29-4 M.J. 1967 phosphates by green algae algae water res. 1: 335-350

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STPP, sodium hexametaphosphate, condensed phosphate degradation tetrapotassium Davis E.M. And Wilcomb and assimilation by selected blue- pyrophosphate 0, 10, 15 7758-29-4 M.J. 1968 green algae algae water res. 2: 311-324 Effect of polyphosphates on chick Inst. Lanwirtsch. Zool. Bienenkd. 27(5): 237- STTP, SHMP, DSP 0, 10, 3 7758-29-4 Karb B. 1971 embryos chicks 251 0, 11, 10, Analytical chemistry of the condensed STPP 9, 7, 5 13573-18-7 Greenfield S 1975 First Edition, pp 1-202. n/a phosphates, Pergamon Press sodium tripolyphosphate, Berenson M.M. And Detergent toxicity: effects on dipotassium phosphate 0, 13 Temple A.R. 1975 Esophageal and gastric mucosa cats clin. Toxicology 8(4): 399-404

Analysis of Mixtures of the Condensed Phosphates by Ion- Exchange Chromatography; II. STPP, dipotassium Mixtures of Ortho-, Pyro-, Tri-, Tetra-, phosphate, tetrasodium 0, 13, Peters TV Jr and Rieman Trimeta-. And Tetrametaphosphates pyrophosphate, 7,11, 8, 9 7758-29-4 (III) Wm 1956 and Graham’s Salt. N/A Analytical Chimica Acta, 14: 131-135 STPP, tripotassium phosphate, trisodium trimetaphosphate, Behavior of the condensed trisodium hydrogen Beukenkamp J., Rieman phosphates in anion-exchange diphosphate 0, 14, 8, 6 7758-29-4 W. and Lindenbaum S. 1954 chromatograpy. n/a Anal. Chem. 26, 3:505-512 Factor Interactions and their STPP, tetrapotassium Hons FM, Steward WM Influence on Hydrolysis of pyrophosphate 0, 15 7758-29-4 and Hossner LR. 1986 Condensed Phosphates in Soils Soil Soil Science: 408-416.

Kinetics of pyro- and sodium tripolyphosphate, tripolyphosphates hydrolyses in the tetrapotassium presence of corn and soybean roots pyrophosphate 0, 15 7758-29-4 Subbarao Y.V. Et al 1977 as determined by NMR spectography roots soil sci soc amer 41: 316-318 sodium tripolyphosphate, tetrapotassium Weaver J.E. And Griffith induction of emesis by detergent Toxicology and applied pharmacology 14: 214- pyrophosphate 0, 15 7320-34-5 J.F. 1969 ingredients and formulations dogs 220 sodium tripolyphosphate, monosodium phosphate, Comparison of Various Phosphate potassium Salts as the Dietary Phosphorus dihydrogenphosphate, 0, 2, 12, Source on Nephrocalcinosis and potassium tripolyphosphate 16 7778-77-0 Matsuzaki H. et al 1999 Kidney Function in Rats Rats J Nutr Sci Vitaminol 45: 595-608

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0, 2, 3, 4, 5, 7,14,15, Emergency do not consume/do not 50, 16, Willhite CC, Ball GL & Bhat use concentrations for blended Human and Experimental Toxicology 32(3) various 10, 8, various VS 2013 phosphates in drinking water various 241–259 sodium tripolyphosphate, Inorganic alkalizers and acidifier monosodium phosphate, under conditions of high urinary Na+ trisodium phosphate, or K+ on cell proliferation potassium and two-stage carcinogenesis in the dihydrogenphosphate 0, 2, 4, 12 7558-80-7 Shibata M.A. Et al 1992 rat bladder Rats Jpn. J. Cancer res. 83: 821-829 sodium tripolyphosphate, comparative promoting activities of monosodium phosphate, phosphate salts on rats two-stage trisodium phosphate, bladder carcinogenesis under potassium conditions of equivalent urinary Na+ teratogenesis, Carciogenesis and Mutagenesis dihydrogenphosphate 0, 2, 4, 12 7558-80-7 Shibata M.A. Et al 1991 or K+ levels Rats 11: 305-316 STPP, monosodium phosphate, trisodium Triphosphate, the key structure of the phosphate, sodium acid ATP molecule responsible for pyrophosphate 0, 2, 4, 5 7758-29-4 Bo X., Burnstock G. 1993 interaction with P2x-purinoreceptors rats Gen. Pharmac. 24(3) 637-640 sodium tripolyphosphate, Hydrolysis and Sorption Reactions of sodium orthophosphate, Orthophosphate, Pyrophosphate, trisodium hydrogen Tripolyphosphate, and diphosphate, trisodium 0, 2, 4, 5, Blanchar R.W., Hossner Trimetaphosphate Anions Added to trimetaphosphate 6, 8 7558-80-7 L.R. 1969 an Elliot Soil soil soil sci soc amer proc 33: 141-144 sodium tripolyphosphate, sodium orthophosphate, trisodium hydrogen Hydrolysis and sorption of ortho-, diphosphate, trisodium 0, 2, 4, 5, Blanchar R.W., Hossner pyro-, tripoly- and trimetaphosphate trimetaphosphate 6, 8 7558-80-7 L.R. 1969 in 32 midwestern soils soil soil sci soc amer proc 33: 622-625 sodium tripolyphosphate, sodium orthophosphate, trisodium phosphate, Rangia cuneata tetrasodium Effects of phosphates on shell growth (marine) and pyrophosphate, sodium 0, 2, 4, 7, Bernhardt, A.M., Kunigelis and calcium carbonate crystal Helisoma duryi hexametaphosphate 10 7558-80-7 S.C., Wilbur K.M. 1985 formation (freshwater) Aquatic Toxicology, 7, 1-13 Editha Karl-Krouper, Clayton F. Callis & Eli stability of condensed phosphates in Industrial and Engineering Chemistry. Vol. 49, STPP, MSP, SAPP 0, 2, 5 7758-29-4 Seifter 1957 very dilute solutions. n/a no. 12, p2061-2062

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The influence of rearing temperatures on the toxicity of various STPP, MSP, SAPP, 0, 2, 5, environmental pollutants for Killifish sodium tetrapolyphosphate (4?) 7758-29-4 Tsuji S. et al 1986 (Oryzias latipes) fish J Hyg Chem esei Kagaku 32(1): 46-53 Inhibitory effects of laundry detergents on the growth of STPP 0, 2, 5, 13 7758-29-4 Yamane A.N. Et al 1984 freshwater algae algae Suishitsu Odaku Kenkyu 7(9):576-582 sodium tripolyphosphate, sodium orthophosphate, sodium acid pyrophosphate, trisodium trimetaphosphate, sodium 0, 2, 5, 8, the effects of phosphate structure on metaphosphate 9 7558-80-7 Harris R.S. Et al 1967 dental caries development in rats Rats J. D. Res. 46(1): 290-294 sodium tripolyphosphate, sodium phosphate, sodium Different Compatibility of acid pyrophosphate, 0, 2, 5, 9, orthophosphates and polyphosphates graham's salt 11 231-449-2 Hahn f, Jacobi H, Seifen E 1958 in chronic feeding tests? rats Arneimittel-forschung 8():286 sodium tripolyphosphate, sodium orthophosphate, trisodium hydrogen diphosphate, tetrasodium pyrophosphate, trisodium trimetaphosphate, sodium 0, 2, 6, 7, hydrolysis of dehydrated sodium hexametaphosphate 8, 10 7558-80-7 Bell R.N. 1947 phosphates soil ind eng chem 39: 136-140 sodium tripolyphosphate, monosodium orthophosphate, tetrasodium The effects of inorganic phosphates pyrophoshpate, sodium Kunigelis S.C. And Wilbur on trochopore larvae of the oyster hexametaphosphate 0, 2, 7, 9 7558-80-7 K.M. 1987 crassostrea virginica oyster larvae int J invert repro and develop 12: 161-172

a comparative study of the cariostatic sodium tripolyphosphate, effect of dietary fluorides, sodium orthophosphate, Muhlemann H.R. And orthophosphates and triphosphates trisodium trimetaphosphate 0, 2, 8 7558-80-7 Konig K.G. 1967 in osborne-mendel rats Rats helv odontol acta 8(1): 56

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INTERNATIONAL PROGRAMME ON 0, CHEMICAL SAFETY 2,3,4,5,7, WORLD HEALTH 9,10,11,1 ORGANIZATION STPP, MSP, DSP, TSP, 2,13,14,1 TOXICOLOGICAL INTERNATIONAL PROGRAMME ON SAPP, TSPP, SMP, SHMP, 5,16,19,2 EVALUATION OF CHEMICAL SAFETY WORLD HEALTH IMP, MKP, DKP, TKP, 0,21,22,2 CERTAIN VETERINARY ORGANIZATION TOXICOLOGICAL TKPP, KTPP, DAP, APP, 4,26,29,3 DRUG RESIDUES IN EVALUATION OF CERTAIN VETERINARY MCP, DCP, TCP/HAP, 0,31,46,4 FOOD WHO FOOD DRUG RESIDUES IN FOOD WHO FOOD CPP, DMP, TMP, MMP, PA 8 N/A ADDITIVES SERIES 17. 1982 Review: Toxicity ADDITIVES SERIES 17.

Integrated Pollution Prevention and Control: Reference Document on Best Available Techniques for the Manufacture of Large Volume Inorganic Risk Assessment guidance on Chemicals - Solids and 2006 - prevention of pollution from ECB.JRC ftp://ftp.jrc.es/pub/eippcb/doc/ [Draft STPP, MCP, DCP 0, 21, 22 7758-29-4 Others industry. Aug manufacture and use ? BREF for LVIC-S products (2005)] Range Finding Toxicity Data: List VII. Acute Toxicity and irritation data on about 200 compounds are presented, STPP, disodium accumulated in a continuing program phosphate, trisodium for screening potential commercial American Industrial Hygiene Association phosphate 0, 3, 4 7758-29-4 Smyth HF et al (1969) 1969 products. Rat Journal, 470-476 sodium tripolyphosphate, trisodium phosphate, Microbiological Quality of Catfish sodium Frames Treated with Selected hexametaphosphate 0, 4, 10 7601-54-9 Marshall D.L., Jindal V. 1997 Phosphates fish j. of food protection 60(9): 1081-1083 Review.Technical, occupational health and environmental aspect of metal degreasing with aqueous STPP, TSP, TKPP 0, 4, 15 7758-29-4 Lavoue et al 2003 cleaner. N/A Annual occupational hygiene.47.441-459

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested sodium tripolyphosphate, trisodium phosphate, tetrasodium pyrophosphate, trisodium Enzymic hydrolysis of trimetaphosphate, sodium 0, 4, 7, 8, polyphosphates in the hexametaphosphate 10 7785-84-4 Ivey J., Shaver K. 1977 gastrointestinal tract rats J. Agric. Food Chem. 25(1): 128-130

STPP, pyrophophosphoric acid, magnesium hydrogen orthophosphate, tricalcium phosphate, monocalcium phosphate, potassium metaphosphate, pentapotassium triphosphate, monopotassium European Parliament and Council phosphate, trisodium 0, 45, 29, Directive No 95/2/EC of 20th phosphate, disodium 24, 21, February 1995 on food additives phosphate, monosodium 17, 16, other than colours and sweeteners phosphate 12, 4, 3, 2 7758-29-4 Anon 1995 (OJ L 61, 18.3.1995, p.1). N/A (OJ L 61, 18.3.1995, p.1).

Dr. Werner Kastner et Dr Toxicity via oral, sub-cutaneous, rats, mice, Toxicite et ecotoxicite des produits de STPP, PA 0, 48 7758-29-4 Peter GODE, Henkel KGaA 1983 cutaneous, intraperitoneal routes rabbits traitement des eaux Ramel C. and Magnusson chemical induction of nondisjunction drosophila STPP, phosphoric acid 0, 48 7758-29-4 J. 1979 in Drosophilia melanogaster Environmental Health perspective 31: 59-66 Effects of temperature and phosphate concentration on rate of sodium tripolyphosphate, sodium pyrophosphate and STPP Sodium pyrophosphate 0, 5 7758-16-9 Chang C. and Racz G.J. 1977 hydrolysis in soil soils can J soil science 57: 271-278 sodium tripolyphosphate, sodium acid Hydrolysis of condensed phosphates pyrophosphate 0, 5 7758-16-9 Clesceri N.L. And Lee G.F. 1965 – II: sterile environment water int. J. air Wat. Poll. 9: 743-751 sodium tripolyphosphate, Crowther J.P. And the hydrolysis of the condensed Sodium pyrophosphate 0, 5 7758-16-9 Westman A.E.R. 1954 phosphates water can j chem 32: 42-48 The Influence of Chain Length on Gosselin RE and Megirian The Metabolic Fate of Condensed STPP, SAPP 0, 5 7758-29-4 R 1955 Phosphates Rat and Rabbit J Pharm Exp.Ther. 114: 402-407

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Hydrolysis of condensed phosphates Internat. Assoc. Great Lakes Res., Proc. 12th STPP, SAPP 0, 5 7758-29-4 Heinke GW 1969 in Great Lakes Waters water Conf:766-773 Independence in hydrolysis of STPP, SAPP 0, 5 7758-29-4 Smith M.J. 1959 condensed phosphates water Can. J. Chem., 37: 1115-1116 Gosselin RE et al Clinical toxicity of commerical Clinical Toxicology of Commercial Products. STPP, SAPP 0, 5 7758-29-4 1984 products 5th Ed.11-121 sodium tripolyphosphate, hydrolysis of sodium pyrophosphate sodium pyrophosphate 0, 5 7758-16-9 Savant N.K. And Racz G.J. 1972 and STPP by plant roots seeds soil science 113(1): 18-22 sodium tripolyphosphate, sodium acid pyrophosphate, sodium hexametaphosphate, 0, 5, 10, Heat-Sensitization of Salmonella by calcium trimetaphosphate n/a 7758-29-4 Seward R.A. Et al 1986 Polyphosphates bacteria J. of food science 51(2): 471-473 sodium tripolyphosphate, sodium pyrophosphate, tripolyphosphate and pyrophosphate tripotassium phosphate 0, 5, 14 7758-16-9 Blanchar R.W., riego D. 1976 hydrolysis in sediments sediments soil sci soc amer proc 40: 225-229

STPP, sodium acid pyrophosphate, tetrasodium pyrophosphate, 0, 5, 7 , Hydrolysis of condensed phosphates monopotassium phosphate 12 7758-29-4 Clesceri N.L. And Lee G.F. 1965 – I: non-sterile environment water int. J. air Wat. Poll. 9: 723-742 Various 0, 5, 7, 8, 19, 18, 16, 46, 15, 14, Kirk-Othmer Encyclopaedia of Chemical 13, 12, Technology. 17, 20, 4, phosphoric acid and phosphates Kirk-Othmar 3, 2 Various Gard 2001 Phosphoric Acids and Phosphates. n/a encyclopedia 2001 sodium tripolyphosphate, sodium acid pyrophosphate, tetrasodium pyrophosphate, trisodium trimetaphosphate, sodium metaphosphate, sodium hexametaphosphate, 0, 5, 7, 8, ABSTRACT: Studies on the CarbP 9, 10, 51 7758-16-9 Zipf. K.. 1957 toxicology of polyphosphates Mouse Arzneimittel 7(7) : 446-447

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested sodium tripolyphosphate, sodium acidpyrophosphate, tetrasodium Inhibitory effects of polyphosphates pyrophosphate, sodium on Clostridium perfringens growth, polyphosphate glassy 0, 5, 7, 9 7758-16-9 Akhtar S. et al 2008 sporulation and spore outgrowth fungus Food Microbiology 25: 802– 808 sodium tripolyphosphate, sodium Effect of Poly- and Pyrophosphates acidpyrophosphate, on the natural Bacteria Flora and tetrasodium inoculated Clostridium sporogenes pyrophosphate, sodium PA 3679 in cooked packaged polyphosphate glassy 0, 5, 7, 9 7758-16-9 Molins R.A. Et al 1985 Bratwurst bacteria J of foof science 50: 876-880 STPP, SAPP, STMP, Reversion of molecularly dehydrated Industrial & Engineering Chemistry, 42 (8): SHMP 0, 5, 8, 10 7758-29-4 Green J 1950 sodium phosphates. n/a 1542-1546 Review of Epidemiological Social Medicine and Public Health. (Toxicité Aiguë Des Chélatant 0, 5, 8, Acute Toxicity: Therapeutic Thérapeutiques Utilisables Dans L’Industrie 10, 11 Chelatants of Use in Nuclear Nucléaire. Revue d’Epidemiologie Medecine STPP 7758-29-4 Chadiot P and Lafuma J 1962 Industry. mice Sociale et Santé Publique. STPP, sodium acid pyrophosphate, trisodium trimetaphosphate, sodium metabolic acidosis and hypocalcemia metaphosphate / 0, 5, 8, as toxic manifestations of polymeric Journal of Pharmacology and Experimental hexametaphosphate 9/10 7758-29-4 Gosselin R.E. Et al 1952 phosphates rats Therapeutics. 117-127. sodium tripolyphosphate, sodium pyrophosphate, Hahn f, Jacobi h, Rummel ABSTRACT: chronic feeding sodium metaphosphate 0, 5, 9 7758-16-9 W. 1956 experiments with polyphosphates Rats Die Naturwissenchaften 43(23): 539-540 Structure and properties of the condensed phosphates. VII. Van Wazer JR, Griffith EJ Hydrolytic degradation of pyro- and STPP, TSPP 0, 7 7758-29-4 and McCullough JF 1955 tripolyphosphate N/A J. Am. Chem. Soc., 77: 287-291

sodium tripolyphosphate, The mechanism of the hydrolysis of sodium pyrophosphate, condensed phosphates. IV. The sodium trimetaphosphate, 7758-29-4, hydrolysis of pyro-, tripoly-, trimeta- sodium 0, 7(or 5), 7722-88-5, Watanable M, Sato S and and tetrametaphosphates in aqueous Bulletin of the Chemical Society of Japan. tetrametaphosphate 8 7785-84-4 Saito H 1976 organic solvents N/A 49(9): 2474-2478

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

0, 7, 11, Irani R.R. and Iron sequestration by STPP 28 7758-29-4 Morgenthaler W.W. 1963 polyphosphates. n/a J. Am. Oil Chem. Soc. 40:283-285 STPP, TSPP, STMP, Hydrolysis rates of inorganic sodium acid polyphosphates in aqueous solution pyrophosphate, disodium 0, 7, 8, 5, as well as in soils and effects on P phosphate 3 7758-29-4 Torres-Dorante L.O. Et al 2005 availability water and soil J plant nutr soil sci 168: 352-358 sodium tripolyphosphate, tetrasodium diphosphate, sodium polyphosphate Fingerhut F., Ruf F., Lang (65% P2O5) 0, 7, 9 7722-88-5 K. 1965 resorption of the polyphosphates rats klin wochensch 43: 956-957 sodium tripolyphosphate, Tetrasodium pyrophosphate, Graham's salt, sodium 0, 7, 9, Metabolism of different activated pentapolyphosphate n/a 231-767-1 Schreier K. and Noller H.G. 1955 polyphosphates Rats Arch. Exper. Path. U Pharmakol. 227: 199-209 STPP, trisodium Dick R.P. And Tabatabai Hydrolysis of polyphosphates by corn trimetaphosphate 0, 8 7758-29-4 M.A. 1986 roots corn Plant and soil 94: 247-256 sodium tripolyphosphate, the hydrolysis and excretion of sodium trimetaphosphate 0, 8 7785-84-4 Gosselin R.E. Et al 1952 polymeric phosphate Rats ??: 180-192 tripolyphosphate and sodium tripolyphosphate, trimetaphosphate in yeast sodium trimetaphosphate 0, 8 7785-84-4 Kornberg S.R. 1955 ABSTRACTs yeast Jourma; of biological cheistry STPP, STMP, TSP, sodium dihydrogen orthophosphate, sodium phosphate-glass, sodium 0, 8, 4, 2, effects of condensed phosphates on ultraphosphate 9, n/a 7758-29-4 El-Reweiny F.M. et al 1976 plant growth and phosphorus uptake grass Plant and soil 44: 1-14 sodium tripolyphosphate, sodium metaphosphate, sodium action of phosphates on experimental hexametaphosphate 0, 9, 10 68915-31-1 Cardenas J. et al 1960 tumors Rats and mice Acta pharmacol. Et toxicol. 17: 157-160 sodium tripolyphosphate, experimental substantiation of sodium metaphosphate, hygienic standardization of sodium sodium Perova N.M.and Sergeev hexametaphopshate and hexametaphopshate 0, 9, 10 68915-31-1 A.N. 1973 tripolyphosphate in drinking water water gisaaa gigiena i sanitariya 38(9): 19-22 Dick R.P. And Tabatabai STPP, SMP, SAPP, STMP 0, 9, 5, 8 7758-29-4 M.A. 1986 Hydrolysis of polyphosphates in soil soil soil science 142(3): 132-140 Dick R.P. And Tabatabai Factors affecting hydrolysis of STPP, SMP, SAPP, STMP 0, 9, 5, 8 7758-29-4 M.A. 1987 polyphosphates in soils soils soil science 143(2): 97-104

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

0,2,3,4,5, 7,10, calcium 0,2,3,4,5,7,10, calcium acid acid phosphate phosphate 7758-29-4 Tompkin RB 1983 Microbial effects of phosphates microbes Journal of food safety. 6:13-27 0,2,3,4,5, 7,12,13,1 STPP, MSP, DSP, TSP, 4,15,16,1 SAPP, TSPP, MKP, DKP, 8,19,20,2 TKP, TKPP, KTPP, DAP, 1,22,24,2 APP, MCP, DCP, TCP, 6,29,30,3 CPP, DMP, TMP, MMP, 1,39,44,4 Ullmann's Encyclopedia of Industrial MALP, BOP, SFP, PA, 7,48,49,5 Chemistry, Author's Edition Phosphoric acid PPA, PyroPA 0 N/A Schrödter K et al 2007 physiochemical properties (pg 23) n/a and Phosphates

STPP and tetrasodium Elliot P, Straka RP and Polyphosphate inhibition of growth of pyrophosphate 0,7 7758-29-4 Garibaldi JA 1964 Pseudomonads from poultry meat. Bacteria Applied microbiology.12(6):517-522 sodium hexametaphosphate, Influence of phosphate compunds on sodium tripolyphosphate, certain fungi and their preservative sodium tetraphosphate and Post FJ, Coblentz WS, effects on fresh cherry fruit (Prunus terasodium pyrophosphate. 10, 0, 7 10124-96-8 Chou TW & Salunkhe DK 1968 cerasus, L.) fungi Applied microbiology. 16(1): 138-142 sodium Steinhardt Bour NJ et al hexqametaphosphate, Effect of level and form of monopotassium phosphorous and level of calcium phosphate, dipotassium intake on Zinc, Iron and Copper phosphate, 10, 12, 13 68915-31-1 1984 bioavailability in man. man Nutrition Research, 4:371-379 sodium hexametaphosphate, effect of normal and high Intakes of dibasic potassium Dymsza H.A., Reussner Orthophosphates and phosphate 10, 13 68915-31-1 G.Jr, Thiessen Jr 1959 metaphosphates in Rats rats j. Nutrition 69: 419-428 sodium K. G. König, Th. M. hexametaphosphate, Marthaler & H. R. sodium acid Mühlemann pyrophosphate, disodium phosphate 10, 5, 3 10124-56-8 1961 rat

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested sodium Batra S.C. hexametaphosphate, sodium acid pyrophosphate, trisodium The ionisation behaviour of some phosphate, disodium 10, 5, 4, poly (meta) phosphates used in food phosphate, STPP 3, 0 10124-56-9 1965 products. n/a J. Food Sci. 30:441-444 sodium FDA - Dietary Supplements [Reserved] hexametaphosphate, Subpart G - Sequestrants, 461. tetrasodium pyrophosphate, sodium acid pyrophosphate, disodium phosphate 10, 7, 5, 3 10124-56-10 Food and Drug Administration, HHS Subpart F Sodium hexametaphosphate and ABSTRACT: mechanisms calcium responsible for the acute toxicity of a hexametaphosphate 10, 9 10124-56-11 Tibdall C.S. et al 1952 phosphate glass Rats fed proc 11(1): 162 sodium metaphosphate Inorganic Chemistry 1. The insoluble, sodium metaphosphates and polyphosphates Ann Reports Progr Chem, 34 (SUPPL: ref hexametaphosphate 11, 10 10361-03-2 Terrey H. 1937 of sodium. n/a topley): 115-122 Structure and properties of the sodium metaphosphate condensed phosphates. III. Solubility insoluble, sodium fractionation and other solubility hexametaphosphate 11, 10 10361-03-2 Van Wazer J R 1950 studies. J Amer. Chem. Soc. 72: 647 - 655. CIR Epxert Panel (2001), Final Report on the Safety sodium metaphosphate Assessment of Sodium insoluble, sodium Metaphosphate, Sodium hexametaphosphate, Trimetaphosphate and Sodium International Journal of Toxicology, 20(Suppl. trisodium trimetaphosphate 11, 10, 8 10361-03-2 Hexametaphosphate, 3):75-89; sodium metaphosphate insoluble, monosodium Zinc, Iron and Copper Availability as phosphate, disodium Zemel MB and Bidari M Affected by Orthophosphates, phosphate, 11, 2, 3 10361-03-2 1983 Polyphosphates and Calcium. rat Journal of Food Science, 48: 567-571 mobilisation of heavy metals from monopotassium river sediments of northern Greece phosphate, STPP 12, 0 7778-77-0 Samanidou V. 1990 by complexing agents rivers Water, air and soil pollution 52: 217-225 potassium dihydrogenphosphate, Infidelity of DNA synthesis in vitro: dipotassium screening for potential metal hydrogenorthophosphate 12, 13 7778-77-0 Sirova MA and Loeb LA 1976 mutagens or carcinogens Science. 194(4272): 1432-1436

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested monopotassium phosphate, dipotassium Influence of inorganic phosphates on phosphate 12, 13 7778-77-0 Torriani A 1960 enzyme formation in E.coli Bacteria Biochem. Biophys. Acta, 38:460-479 potassium Effects of phosphorus dihydrogenorthophosphate, Goldsmith RS, Jowsey J, supplementation on serum dipotassium Dube WJ, Riggs BL, parathyroid hormone and bone Journal of clinical Endocrinology and hydrogenorthophosphate 12, 13 7778-77-0 Arnaud CD & Kelly PJ 1976 morphology in osteoporosis human Metabolism. 43(3): 523-532 monopotassium phosphate, dipotassium phosphate, monosodium Effect of phosphates on phophatase phosphate, disodium 12, 13, 2, Kalashnikova NA & synthesis by the culture Aspergillus phosphate 3 7778-77-0 Rodenvich 1970 awamori strain 22 n./a Prikl Biokhim Mikrobiol. 6: 516-519

Greater effect of dietary potassium tripolyphosphate than of potassium potassium dihydrogenophosphate on the dihydrogenphosphate nephrocalcinosis and proximal (KH2PO4), potassium tubular function in female rats from tripolyphosphate 12, 16 7778-77-0 Matsuzaki H. et al 2001 the intake of a high-phosphorus diet rats Biosci. Biotechnol. Biochem 65(4): 928-934

Potassium dihydrogen orthophosphate, Sodium and potassium pyrophosphate, Potassium triphosphate, Potassium trimetaphosphate Activity Coefficients of Some 12, 16 7778-77-0 Miller G and Porter AS 1967 Polyphosphates in Aqueous Solution. N/A Trans Faraday Soc, 63: 335-340 monopotassium phosphate, monoammonium 7778-77-0, Das quaternare system K2O-NH3- phosphate 12, 18 7726-86-1 Janecke E 1927 P2O5-H2O bei 0° und 25° N/A Z Physik Chem. 127:71-92 Thilo E. potassium dihydrogen orthophosphate, disodium Zur Chemie der kondensierten dihydrogenorthophosphate 12, 2 7778-77-0 1956 Phosphate. Chem. Technol., 8:251-270 Silverberg SJ et al The Effect of Oral Phosphate Administration on Major Indices of monopotassium phosphate Skeletal Metabolism in Normal Journal of Bone and Mineral Research, 1(4): , monosodium phosphate 12, 2 7778-77-0 1986 Subjects. human 383-388

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Griffith EJ, A nomograph for the hydrolytic monopotassium phosphate degradation of pyrophosphates and , monosodium phosphate 12, 2 7778-77-0 1959 tripolyphosphates, Industrial and Engineering Chemistry, 51: 240. potassium dihydrogen Effect of phosphate supplements on phosphate and disodium Jowsey J and soft-tissue calcification and bone hydrogen phosphate 12, 2 7778-77-0 Balasubramaniam P 1972 turnover. Clinical Science. 42: 289-299 monopotassium phosphate, disodium pyrophosphate, sodium tripolyphosphate, (NH4)6P4O13 (Hexa- ammonium tetraphosphate), Sodium Methods for Differentiated phosphate Glass Type, 5, Determination of Orthophsophate, 15, 25, 35, 45, 65, 75 Mussig-Zufica VM and Condensed Phosphates and 12, 2, 0 7778-77-0 Jekel M 1992 Polyphosphate N/A Z Wasser-Abwasser-Forsch, 25: 353-356 Effect of dietary Ca and Cd level of pregnant rats on reproduction and on potasium phosphate, Pond W.G. And Walker Dam and progeny tissue Mineral Proceedings of the soc. For exp. Biology and dicalcium phosphate 12, 22 7757-93-9 E.F. 1975 concentration (38606) Rats medicine 148: 665-668 effect of dietary Ca and P levels from monopotassium 40 to 100 kg bodyweight on weight phosphate, dicalcium Pond WG, Walker EF and gain and soft tissue mineral phosphate 12, 22 7778-77-0 Kirtland D 1978 concentrations. Pigs Journal of animal science. 46(3): 686-691 orthophosphate mixture: Effect of orthophosphate on urinary monopotassium phosphate 7778-77-0, Fleisch H, Lausanne MD & pyrophosphate excretion and the and disodium phosphate 12, 3 7558-79-4 Care AD 1964 prevention of urolithiasis man The Lancet. May 16:1065-1067 dipotassium phosphate, Garen A and Levinthal C A Fine-Structure Genetic and sodium acid Chemical Study of the Enzyme pyrophosphate 12, 5 7757-93-9 1960 Alkaline Phosphatase of E.coli. E.coli unknown Phosphorus balances of adults Potassium phosphate, 7778-77-0 Moon W-H, Malzer JL & consuming several food Journal of The American Dietetic Association. dicalcium phosphate 12,22 7757-93-9 Clark HE 1974 combinations Man 64: 386-390

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Dipotassium phosphate, monocalcium phosphate, 7758-11-4, dicalcium phosphate, 7758-23-8, copper (II)- 7757-93-9, Structure de l'ion PO43- dans hydroxyphosphate, 13, 21, 12158-74-6, l'anhydride phosphorique et les tetrasodium pyrophosphate 22, 38, 7 7722-88-5 Duc-Maugé C 1959 phosphates métalliques N/A Bull Soc Chem France: 1032-1042 Schneider P, Ober KM and Contribution to the phosphate- Uerberberg H induced nephropathy in the dog. Comparative light and electron microscopic investigations on the proximal tubule after oral application dipotassium phosphate, of K2HPO4, Na2HPO4, KCl and disodium phosphate 13, 3 7758-11-4 1981 NaCl. Experimental pathology 19: 53-65 Lehman JT Ecological and nutritional studies on Dinobryon Ehrenb.: Seasonal dipotassium phosphate, periodicity and the phosphate toxicity disodium phosphate 13, 3 7758-11-4 1976 problem. dinobryon Limnology and Oceanography, 21(5): 646-658

Stream Pollution, Toxicity to Gambusia affinis of certain pure TKP, MSP, SAPP 14, 2, 5 7778-53-2 Wallen IE et al 1957 chemmicals in turbid water. fish Sewage and industrial wastes, 29(6): 695-711 potassium pyrophosphate, Hydrolysis and uptake of pyrophosphoric acid 15, 50 7320-34-5 Gilliam J.W. 1970 pyrophosphate by plant roots plants soil sci soc amer proc 34: 83-86 monoammonium phosphate, tripotassium phosphate, disodium Ammonium dihydrogen phosphate prepared at phosphate, monosodium 18, 14, 3, Phosphoric acid prepared at the 59th the 27th JECFA (1983) published in 1983 and phosphate 2 7722-76-1 JECFA 59th 2002 JECFA n/a 1992. Revised at the 59th JECFA (2002). monoammonium phosphate, diammonium 7722-76-1, Ross WH, Mertz AR & Preparation and properties of the Industrial and Engieneering chemistry. 21(3): phosphate 18, 19 7783-28-0 Jacob KD 1929 ammonium phosphates n/a 286-288

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested monoammonium phosphate, diammonium Research Report No. 70: Effects of Department of Sustainability and Environment, phosphate, calcium 233-330-0, fire retardant on soils of heathland in PO Box 500, East Melbourne, Victoria 3002 phosphate 18, 19 231-987-8 Hopmans P and Bickford R 2003 Victoria (ISBN 1 74106 903 3)

Ammonium phosphate, 233-330-0, Effects of fire retardant on water diammonium phosphate 18, 19 231-987-8 Norris LA and Webb WL 1989 quality USDA Forest Service Gen Tech Rep PSW-109 monoammonium Fazekas IG Fazekas IG (1954) Vergößerung der Nebenschilddrüsen? durch einfach acidotische Verbindungen. Enlargement of parathyroid glands by simple acidic compounds. phosphate, disodium phosphate 18, 2 7722-76-1 1954 Virchows Archiv 324: 531-542 19, 18, 16, 15, 14, 13, [13, 11, 10, 7, 5, 3, 2], 12, 10, 5 8, Furia T E Various 5, 4, 3, 2 various 1972 Handbook of Food Additives N/A Handbook of food additives.CRC

reaction products of polyphosphates diammonium and orthophosphates with soils and orthophosphate, 7783-28-0, influence on uptake of phosphorus by ammonium polyphosphate 19, 20 14728-39-3 Subbarao Y.V. And Ellis R. 1975 plants soil soil sci soc amer proc. 39: 1085-1088 Chemical forest fire retardants: acute diammonium phosphate, 7783-28-0, Johnson W.W., Sanders toxicity to five freshwater fishes and a ammonium polyphosphate 19, 20 14728-39-3 H.O. 1977 Scud fish and scud us fish wildlife serv tech pap 91: 1-8 diammonium reactions of ammonium ortho- and orthophosphate, 7783-28-0, polyphosphate fertilizer in soil: I ammonium polyphosphate 19, 20 14728-39-3 Khasawneh F.E. Et al 1974 Mobility of Phosphorus soils soil sci soc amer proc 38: 446-451 diammonium reactions of ammonium ortho- and orthophosphate, 7783-28-0, polyphosphate fertilizer in soil: II ammonium polyphosphate 19, 20 14728-39-3 Khasawneh F.E. Et al 1979 Hydrolysis and reactions with soil soil soil sci soc amer proc 43: 52-58 Sutton C.D., Gunary D. and diammonium Larsen S. Pyrophosphate as a source of orthophosphate, 7783-28-0, phosphorus for plants II. Hydrolysis ammonium polyphosphate 19, 20 14728-39-3 1966 and initial uptake by a barley crop. Soil Sci., 101(): 199-204

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested sodium phosphate, lead Lead poisoning. Newer concepts in New York State Journal of Medicine. 38(20): phosphate 2 (?) 7558-80-7 Gray I and Greenfield I 1938 treatment. human 1313-1319 Ritskes-Hoitinga J., sodium dihydrogen Lemmens A.G. And Nutrition and kidney calcification in phosphate 2, 7558-80-7 Beynen A.C. 1989 rats Rats Laboratory animals 23: 313-318 A clinical study concerning the anticariogenic effects of NaH2PO4- Anhydrous sodium enriched breakfast cereals in dihydrogen orthophosphate institutionalized subjects: results after NaH2PO4 2, (3) 7558-80-7 Brewer H.E. Et al 1970 two years human J. Amer. Dent. Assoc. 80: 121-124 monosodium phosphate Lorenz B et al Purification and Characterization of (MSP), sodium an Exopolyphosphatase from The Journal of Biological Chemistry 269(35): tripolyphosphate (STPP) 2, 0 7558-80-7 1994 Saccharomyces cerevisiae. n/a 22198-22204. sodium phosphate, sodium The effect of the complex-forming hexametaphosphate, Borenstein M.K. And amorphous sodium phosphates on monosodium phosphate 2, 10, 8 7558-80-7 Schwartz C. 1948 the calcium retention of rats Rats J Nutr. 36: 681-694

Anhydrous sodium dihydrogen orthophosphate NaH2PO4, monopotassium Effect of phosphate and pH on phosphate, dipotassium Handelman S.L., Kreinces Streptococcus mutans acid phosphate 2, 12, 13 7558-80-7 G.H. 1972 production and growth bacteria J. Dent. Res. 52(4): 651-657 Mode of Action of Pharmacological monosodium phosphate, Doses of Cholecalciferol during monoammonium Parturient Hypocalcemla In Dairy phosphate 2, 18 7558-80-7 Reinhardt TA & Conrad HR 1980 Cow. cows J Nutr. 110:1589-1596

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Sodium dihydrogen phosphate, Calcium sodium magnesium phosphate, Calcium hydrogenorthophosphate/C alcium dihydrogenorthophosphate, Calcium bis(dihydrogenorthophosph Investigations on the availability of ate), Calcium-sodium- inorganic phosphate from different phosphate 2, 21, sources with growing white Pekin 22,23 7558-80-7 Wendt P et al 2004 ducks Pekin duck Poult. Sci. (2004) 83:1572-1579. Comparison and evaluation of bone Anhydrous monosodium Shastak Y, Witzig M, measurements for the assessment of phosphate, anhydrous 7558-80-7 Hartung K, Bessei W & mineral phosphorus sources in dibasic calcium phosphate 2, 22 7757-93-9 Rodehutscord M 2012 broilers Chicken Poult Sci. 9(9): 2010-2200

Kinetics of phosphate absorption in monosodium phosphate, lactating dairy cows after enteral calcium hydrogen 7757-93-9, Grunberg W, Dobbelaar P administration of sodium phosphate phosphate 2, 22 7758-80-7 & Breves G 2013 or calcium phosphate salts cows British Journal of Nutrition (2013) 1-12 monosodium phosphate, effect of sodium phosphate on basal disodium phosphate 2, 3 7558-80-7 Abelin. J. Kobori. B 1927 metabolism rats Biochem Z., 180():211-217 sodium phosphate monobasic, sodium phosphate dibasic 2, 3 7558-80-7 Haut L.L. Et al 1980 Renal toxicity of phosphate in rats rats Kidney international 17: 722-731 monosodium phosphate ABSTRACT: The clinical effect of (75% of the mixture), phosphate-enriched breakfast cereals disodium phosphate (25% on dental care incidence in adolscent of mixture) 2, 3 7558-80-7 Rowe N.H. Et al 1974 children human J. D. Res spec issue, 53: 605 Monobasic sodium A combined proteome and phosphate (NaH2PO4) and 7558-80-7, microarray investigation of inorganic dibasic sodium phosphate 7558-79-4 Conrads KA, Yi M, phosphate-induced pre-osteoblast (Na2HPO4) 2, 3 Simpson KA et al 2005 cells Mol Cell Proteomics, 4: 1284-1296 sodium phosphate Fatal acute sodium phosphate Acta gastroenterol. belg., 2005, 68, preparation -MSP and DSP 2, 3 7758-80-7 Farah R 2005 enemas intoxication human 392-393

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ABSTRACT: North Dakota field test sodium dihydrogen of cariostatic effect of 1% sodium phosphate, disodium dihydrogen phosphate and disodium phosphate, trisodium hydrogen phosphate added to trimetaphosphate 2, 3, 0 7558-80-7 Peterson J.K. 1969 presweetened breakfast cereals human J. D. Res. 1308 monosodium phosphate, The Pharmacological basis of therapeutics. 9th disodium phosphate, The Pharmacological basis of Edn. calcium phosphate 2, 3, 21 7558-80-7 Goodman and Gliman 1996 therapeutics Goodman & Gilmans sodium dihydrogen orthophosphate, disodium renal damage following the ingestion phosphate, trisodium of a diet containing an excess of phosphate, phosphoric acid 2, 3, 4, 48 7558-80-7 MacKay E.M. And Olivier J. 1935 inorganic phosphate rats j. exp. Med. 61: 319 Food phosphates: sodium orthophosphates, potassium orthophosphates, calcium orthophosphates, sodium pyrophosphates, potassium 2, 3, 4, 5, pyrophosphates, calcium 6, 7, 12, pyrophosphates, 13, 14, potassium 15, 21, tripolyphosphate, 22, 23, potassium polyphosphates, 24, 25, calcium sodium 26, 16, Food additives: Doctors warn of poylphosphate 17, 20, 45 Various Gruber C 2012 artificial phosphate N/A Spiegel Online sodium dihydrogenorthophosphate, disodium hydrogenorthophosphate, 7558-80-7, trisodium orthophosphate, 7558-79-4, tetrasodium 7601-54-9, Viscometric studies of solutions of pyrophosphate, sodium 7722-88-5 sodium phosphates, graham salts tripolyphosphate, sodium 2, 3, 4, 7, 7758-29-4, Nakagaki M, Ohashi S and and vanadium-containing graham Viscosities of sodium phosphates and polyphosphate 0, 9 68915-31-1, Minato F 1963 salt N/A grahams salts. 36(3)

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested monosodium phosphate, disodium phosphate, Toxicity of phosphates, in relation to Journal of Pharmacology and Experimental phosphoric acid 2, 3, 48 7558-80-7 Binger C 1918 blood calcium and tetany dog Therapeutics. 10:105

Complex sodium phosphate and trisodium phosphate included in the In vitro methods for estimating eye light duty liquid cleaner and irritancy of cleaning products phase I: granular laundry detergent 2, 4 7558-80-7 Booman KA et al 1988 Preliminary assessment rabbit eye N/A monosodium phosphate, Potential biological hazards of trisodium phosphate commercially available cleansers for Journal of Toxicology and Environmental 2, 4 7558-80-7 Osterburg RE 1977 dentures. N/A Health, 3: 969-977 disodium phosphate, sodium pyrophosphate 2, 5 7558-80-7 Datta P.K. Et al 1962 Biological effects of food additives rats Sci. Food Agric. 13: 556-566 sodium dihydrogenorthophosphate, sodium acid 7558-80-7, pyrophosphate 2, 5 7758-16-9 Morley GW 1953 The system H2O-NaPO3 N/A J Am Chem Soc 75:5794-5797 sodium phosphate, sodium Further tests on the tolerability of acid pyrophosphate, 2, 5, 9, phosphates following chronic graham's salt 11 231-449-2 Hahn F, Seifen E 1959 application rats Arneimittel-forschung 9():501 monosodium phosphate, sodium acid pyrophosphate, tetrasodium Inhibition of Asperigillus flavus and pyrophosphate, sodium selected Gram-positive bacteria by hexametaphosphate and Knabel SJ, Walker HW & chelation of essential metal cations sodium tripolyphosphate 2, 5, 7 7558-80-7 Hartman PA 1991 by polyphosphates. Bacteria JOURNAL OF FOOD PROTECTION, 54

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested sodium phosphate monobasic, sodium acid pyrophosphate, tetrasodium pyrophosphate, sodium polyphosphate, sodium metaphosphate, potassium metaphosphate, calcium phosphate, monobasic, calcium phosphate dibasic, 2, 5, 7, 9, ferric pyrophosphate, 10, 17, sodium 21, 22, Data book of chromosomal aberration test in monoflurophosphate 28, 47 7558-80-7 Ishidate M, Sofuni T. 1988 chromosomal aberration test in vitro In vitro vitro sodium phosphate, monobasic, sodium acid pyrophosphate, potassium metaphosphate, sodium metaphosphate (different primary mutagenicity screening of bacteria CAS number to that 2, 5, n/a, food additives currently used in salmonella considered by IPC) 17 7558-80-7 Ishidate M. et al 1984 Japan (ames test) Fd. Chem. Toxic. 22(8): 623-636 sodium phosphate, monobasic, sodium acid pyrophosphate, potassium metaphosphate, sodium metaphosphate (different primary mutagenicity screening of CAS number to that 2, 5, n/a, food additives currently used in hamster considered by IPC) 17 7558-80-7 Ishidate M. et al 1984 Japan fibroblasts Fd. Chem. Toxic. 22(8): 623-636 sodium phosphate monobasic, sodium acid pyrophosphate, tetrasodium pyrophosphate, sodium polyphosphate, potassium metaphosphate, ferric 2, 6, 7, 9, pyrophosphate 17, 28 7558-80-8 Ishidate M. 1991 test on chemicals in bacteria bacteria data book of mutagenicity

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested disodium hydrogenphosphate, tetrasodiumpyrophosphate, 7558-79-4, Untersuchungen zum calcium- und sodium tripolyphosphate, 7722-88-5, Feldheim W and phosphorstoffwechsel beim grahams salt 2, 7, 0, 11 7758-29-4 Hesselbach C 1985 menschen. Minature pig Art Ernahr. 10. 30-33 monosodium phosphate, tetrasodium pyrophosphate, sodium hexametaphosphate, dipotassium phosphate, Toxicity and Teratogenicity of 80 food monocalcium phosphate, 2, 7, 10, additives chemicals in the developing Toxicology and applied pharmacology 56: 265- tricalcium phosphate 12, 21, 24 7778-77-0 Verret J. et al 1980 chicken embryo chicken embryo 273 ABSTRACT: effects on long- continued ingestion of sodium sodium orthophosphate, phosphate upon the parathyroid, sodium metaphosphate 2, 9 7558-80-7 Saxton J.A. And Ellis G.H. 1941 kidneys and bones of mature rats Rats am j path 17: 590 monosodium phosphate, sodium hexametaphosphate, anticoagulant boll soc ital biol sper 26 (chem abstr 45-8643): hexametaphosphate 2, 9 68915-31-1 Tria E. 1950 actin in vivo and in vitro dog 113 Association Between Oral Sodium mixture: monosodium Phosphate Bowel Preparations and phosphate and disodium Kidney Injury: A Systematic Review American Journal of Kidney Diseases, Vol 53, phosphate 2,3 n/a Brunelli SM 2009 and Meta-analysis human No 3 (March), 2009: pp 448-456

Phosphate excretion and parathyroid disodium phosphate and Harden RM, Harrison MT & function after radioiodine therapy and monosodium phosphate 2,3 7558-80-7 Alexander WD 1963 thyroidectomy man Clin. Sci. 25: 27-36 Nishida Y, Taketani Y, Yamanaka-Okumura H, Imamura F, Taniguchi A, Neutral sodium phosphate Sato T, Shuto E, Nashiki K, Acute effect of oral phosphate (mixture of Na2HPO4 and 7558-80-7 Arai H, Yamamoto H & loading on serum fibroblast growth NaH2PO4) 2,3 7558-79-4 Takeda E 2006 factor 23 levels in healthy men Man Kidney International. 70: 2141-2147 The effect of a high phosphorus Neutral sodium phosphate intake on total and ultrafiltrable (mixture of Na2HPO4 and 7558-80-7 plasma calcium and on phosphate NaH2PO4) 2,3 7558-79-4 Smith DA & Nordin BEC 1964 clearance Man Clin Sci. 26: 479-486

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

The effects produced by an increase in the calcium and phosphorus content of the diet on the calcuim mixture of mon- and Haldi J, Bachmnn G, Wynn and phosphorus balance and on dibasic sodium phosphate 2,3 n/a W and Ensor C 1939 various bodily constiuents of the rat rats The Journal of Nutrition 1939 monosodium phosphate, disodium phosphate, Incidence of urinary calculi in sheep sodium tripolyphosphate, Bushman DH, Emerick RJ as affected by various dietary dicalcium phosphate 2,3,0,22 7558-80-7 & Embry LB 1965 phosphates sheep J Anim Sci 1965. 24:671-675.

Neutral sodium and potassium phosphate (4:1 7558-80-7 mixture of 7558-79-4 Dietary intake of phosphorus Na2HPO4/K2HPO4 and 7778-77-0 Portale AA, Halloran BP & modulates the circadian rhythm in NaH2PO4/KH2PO4) 2,3,12,13 7758-11-4 Morris RC 1987 serum concentration of phosphorus Man J Clin Invest. 80: 1147-1154

Neutral sodium and potassium phosphate (4:1 7558-80-7 Physiologic regulation of the serum mixture of 7558-79-4 concentration of 1,25- Na2HPO4/K2HPO4 and 7778-77-0 Portale AA, Halloran BP & dihydroxyvitamin D by phosphorus in NaH2PO4/KH2PO4) 2,3,12,13 7758-11-4 Morris RC 1989 normal men Man J Clin Invest. 83: 1494-1499 monosodium phosphate, Anderson BG The toxicity thresholds of various disodium phosphate, sodium salts determined by the use daphnia trisodium phosphate 2,3,4 7558-80-7 1946 of Daphnia magna. magna. Sewage works Journal. 18(1): 82-87 monosodium phosphate, disodium phosphate, trisodium phosphate, tetrasodium pyrophosphate 2,3,4,7 Starkenstein E 1911 Ionenwirkkung der Phosphorsauren ? Biochem Z. xxxii: 243-264 sodium phosphate' - likely Seol DC, Hong SN, Kim Change in renal function after to be a mixture of MSP and JH, Sung IK, Park HS, Lee sodium phosphate preparation for World Journal of Gastroenterology (2010) April DSP 2,3? n/a Jh and Shim CS 2010 screening colonoscopy human 28; 16(16): 2010-2016 Polyethylene glycol vs. sodium phosphate for sodium phosphate' - likely bowel preparation: A treatment arm to be a mixture of MSP and Juluir R, Eckhart G and metaanalysis of randomized DSP 2,3? n/a Imperiale TF 2011 controlled trials human BMC Gastroenterology 2011, 11:38

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Acute Phosphate Nephropathy following Oral Sodium Phosphate sodium phosphate' - likely Markowitz GS, Stokes MB, Bowel Purgative: An to be a mixture of MSP and Radhakrishnan J,and Underrecognized Cause of Chronic DSP 2,3? n/a D’Agati VD 2005 Renal Failure human J Am Soc Nephrol 16: 3389–3396, 2005 SIDS intial assessment SIDS intial assessment US ICCA SIAM phosphates 4-2007.pdf ammonium polyphosphate, profile.SIAM.24. profile.SIAM.24. monoammonium phosphate, diammonium 20, 18, phosphate 19, 68333-79-9 2007 rats, fish monocalcium phosphate effects of phosphate sources on the (hydrate), dipotassium mycelial growth of gigaspora Revista Brasileira de Ciencia do solo 156: 169- phosphate 21, 12 7758-23-8 Da silva L.R.C. Et al 1991 gigantea in vitro fungus 172 monocalcium phosphate, dipotassium Krook L, Lutwak L, hydrogenorthophosphate, Hnrikson P, Kallfelz F, Reversibility of Nutritional sodium Hirsch C, Romanus B, Osteoporosis: Physicochemical Data dihydrogenorthophosphate Belanger LF, Marier JR on Bones from an Experimental monohydrate 21, 12, 2 7758-23-8 and Shefft BE 1971 Study in Dogs dogs The journal of nutrition. 101:233-246 True absorption of phosphorus from di calcium phosphate, mono Dicalcium phosphate, ammonium phosphate, triple monoammonium 7757-93-9 superphosphate and urea-phosphate phosphate, triple super 7722-76-1 in cattle by the radio phosphorus phosphate, urea-phosphate 21, 18 65996-95-4 Da Silva Filho JC 1990 dilution technique Cattle National Technical Information Service Report monocalcium phosphate, 46th JECFA. diammonium phosphate, sodium metaphosphate insoluble, sodium hexametaphosphate, 21, 19, Published in 1967, 1992 and 1996. Revised at sodium polyphosphate 11, 10, 9, 7758-23-8 1996 JECFA N/A the 26th JECFA 1982.

Correlation of biological value of feed dibasic calcium phosphate phosphates with their solubility in dihydrate, mono-dicalcium water, dilute hydrogen chloride, dilute phosphates, di- citric acid and neutral ammonium monocalcium phosphates. 21, 22 7758-23-8 Sullivan TW 1992 citrate. turkey Poultry Science. 71:2065-2075

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Evaluation of new and established monocalcium phosphate, feed phosphates in turkey starter dicalcium phosphate 21, 22 7758-23-8 Sullivan TW et al 1989 diets turkey Poultry Science. 68(1):143 bioavailability of phosphorous in monocalcium hposphate, commercial phosphate supplements dicalcium phosphate 21, 22 7758-23-8 Waibel PE et al 1984 for turkeys. turkey Poultry Science. 63:730-737 Nitrogen and Phosphorus Partitioning Knowlton KF, Herbin JH, in Lactating Holstein Cows Fed monocalcium phosphate, Meister-Weisbarth MA and Different Sources of Dietary Protein dicalcium phosphate 21, 22 7558-23-8 Wark WA 2001 and Phosphorus cows J. Dairy Sci. 84:1210–1217 Ellam T, Wilkie M, Chamerlain J, Crossman Dietary Phosphate Modulates monocalcium phosphate, D, Eastell R, Francis S and Atherogenesis and Insulin Resistance Arteriosclerosis, Thrombosis and vascular dicalcium phosphate 21, 22 7758-23-8 Chico TJA 2011 in Apolipoprotein E Knockout Mice Mice biology. 2011:31 The effects of phosphorus monocalcium phosphate, supplementation to common carp dicalcium phosphate 21, 22 7758-23-8 Hepher B & Sandbank S 1984 diets on fish growth. fish Aquaculture, 36:323-332 Laying hens respond differently to high dietary levels of phosphorus in monocalcium phosphate, monobasic and dibasic calcium dicalcium phosphate 21, 22 7758-23-8 Keshavarez K 1994 phosphate. hens Poultry Science. 73: 687-703 Calcium bis(dihydrogenorthophosph ate), Calcium hydrogenorthophosphate, ammonium dihydrogenorthophosphate, Thermomagnesium phosphate Laboratory evaluations of feed-grade 21, 22, 18 7758-23-8 Lima FR et al 1999 and agricultural-grade phosphates N/A Poult. Sci. 78(12):1717-1728 Influence of dietary calcium, phosphorous, zinc and sodium calcium phosphate phytate level on cateract incidence, monobasic, calcium growth and histopathology in juvenile phosphate dibasic, sodium Chinook salmon (Oncorhynchus phosphate monobasic. 21, 22, 2 7758-23-8 Richardson NL et al 1985 tshawytscha). fish American Institute of Nutrition. 553-567

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Monocalcium phosphate, Dicalcium phosphate, Beta- tricalcium phosphate, Tricalcium phosphate Studies on the availability of calcium 21, 22, orthophosphate to chickens and 23, 24 7758-23-8 Gillis MB et al 1952 turkeys chicken J. Nutr. 78(2): 155-161 Wise DL, Trantolo DJ, Altobelli DE, Yaszemski Encyclopaedic handbook of MCP, DCP, HAP, Calcium 21, 22, MJ, Gresser JD and biomaterials and bioengineering. Part sodium phosphate, β-TCP, 23, 24 7758-23-8 Schwartz B: Applications. Vol 1 Dicalcium phosphate, tricalcium phosphate, The action of water upon the monocalcium phosphate 21, 22, 24 7558-23-8 Cameron FK and Siedell A 1910 phosphates of calcium. N/A J Am Chem Soc 26: 1454-1463 Moncalcium phosphate Handling of non-sink conditions: In hydrate, dibasic calcium vitro dissolution rates of some phosphate, basic tricalcium common pharmaceutical calcium Drug development and industrial pharmacy, phosphate 21, 22, 24 7758-23-8 Carstensen JT 1988 salts N/A 14(4): 1971-1989 monocalcium phosphate, Characterisation of phosphate dicalcium phosphate, Frossard E, Tekely P and species in urban sewage sludges by tricalcium phosphate, 21, 22, 24 7758-23-8 Grimal JY 1994 high-resolution solid-state 31P NMR. sewage sludge European Journal of Soil Science. 45: 403-408 monocalcium phosphate, dicalcium phosphate, tricalcium calcium phosphate fertilizers: II a phosphate/hydroxyapatite, 21, 22, petrographic study of their alteration octocalcium phosphate 24, n/a 7758-23-8 Lehr J.R. And Brown W.E. 1958 in soils soil soil sci soc amer proc 22: 29-32 monocalcium phosphate, dicalcium phosphate, tricalcium calcium phosphate fertilizers: I phosphate/hydroxyapatite, 21, 22, availability to plants and solubility in octocalcium phosphate 24, n/a 7758-23-8 Terman G.L. Et al 1958 soils varying in pH ryegrass soil sci soc amer proc 22: 25-29 monocalcium phosphate, Bioavailability of bone precipitated dicalcium phosphate, 21, 22, Sullivan TW and Douglas dicalcium phosphate in turkey starter defluorinated phosphate n/a 7758-23-8 JH 1987 diets. turkey Poultry Sci(1): 182

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested monocalcium phosphate, A triple response method fpr dicalcium phosphate, determining biological value of defluorinated phosphate, 21, 22, phosphorus sources with young tricalcium phosphate n/a, 24 7758-23-8 Sullivan TW 1966 turkeys turkey Poultry Science. 45:1236-1245

Triple super phosphate, rock phosphate, 7758-23-8, Lead and zinc bioavailability to monocalcium phosphate, 65996-95-4, Ownby DR, Galvan KA and Eisenia fetida after phosphorus tricalcium phosphate 21, 23 7758-87-4 Lydy MJ 2005 amendment to repository soils Environmental Poluution, 136: 315-321 effects of inorganic salts upon biology and development of acarid mites> IV. Effects of calcium phosphate surplus in food upon fecondity, life spam and development monocalcium phosphate, of copra mite Tyrophagus tricalcium phosphate 21, 24 7758-23-8 Ignatowicz S. 1980 putrescentia acarid mites polish J entomo 50: 289-298 monocalcium phosphate, calcium pyrophosphate, monosodium phsohate, sodium acid pyrophosphate, calcium Biological avaiilability of nutrients in metaphosphate, sodium 21, 26, 2, feeds: availability of major mineral metaphosphate 5, 7758-23-8 Peeler HT 1972 ions. sheep J Anim Sci 1972. 35:695-712. monocalcium phosphate, Magnesium phosphate The dissociation of Calcium and 21, 29 7758-23-8 Greenwald I et al 1940 Magnesium Phosphates. N/A J Biol Chem, 135: 65-67 Calcium orthophosphate, Canton Castillo JG, Moguel Poultry manure and litter as phosphoric acid, rock 7758-23-8 Ordonez Y & Castellanos phosphorus sources for ruminant phosphate 21, 48 7664-38-2 Ruelas AF 1996 feedstufs Sheep Tec Pecu Mex. 34(3): 160-166 monocalcium phosphate, dicalcium phosphate, 7758-23-8, Structure and chemistry of the tricalcium phosphate , 7757-93-9, apatites and other calcium hydroxyapatite 21,22,24 1306-06-5 Elliot JC 1994 orthophosphates N/A Studies in inorganic chemistry Availability to ponies of calcium and dicalcium phosphate and 7757-93-9, phosphorus from various monosodium phosphate 22, 2 7758-80-7 Hintz HF & Schryver HF 1972 supplements ponies Journal of Animal Science. Vol 34 (6) 979-980

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R. A. ARGENZIO, J. E. dicalcium phosphate, LOWE, H. F. HINTZ, AND Calcium and Phosphorus monosodium phosphate 22, 2 7757-93-9 H. F. SCHRYVER 1974 Homeostasis in Horses horse J Nutr. 104. 18-27

Calcium hydrogen orthophosphate, Calcium bis(dihydrogenorthophosph ate), Ammonium Relative bioavailability of phosphorus dihydrogenorthophosphate in feed and agricultural phosphates 22, 21, 18 7757-93-9 Fernandes JIM et al 1999 for poultry. poultry Poult. Sci. 78:1729-1736. calcim Preparation of octacalcium hydrogenorthophosphate, phosphate by the tricalcium phosphate 22, 23 7757-93-9 Monma H 1980 hydrolysis of α- tricalcium phosphate n/a Journal of Materials Science.15:2428-2434 Phosphates bicalcique et tricalcique dicalcium phosphate, 231-826-1, dans l'alimentation des animaux tricalcium phosphate 22, 23 7758-87-4 Poty P-L 1932 domestiques Ecole Nationale Veterinaire D'Alfort calcium The hydrolysis of anhydrous hydrogenorthophosphate dicalcium phosphate in (DCP), hydroxyapatite 22, 24 7757-93-9 Ishikawa K & Eanes ED 1993 hydroxyapatite n/a Journal of Dental Research. 72(2): 474-480 The effect of feeding calcium phosphate salts with different dicalcium phosphate solubilities on dental caries, the dihydrate, dicalcium composition of the saliva and the pyrophosphate 22, 26 7789-77-7 Buttner W. and Muhler J.C. 1958 femur of rats Rats J. D. Res. 37(5): 860-864 Soluble complexes in the systems Calcium dicalcium phosphate dihydrate or hydrogenorthophosphate, dimagnesium phosphate trihydrate Dimagnesium phosphate equilibrated with aqueous salt 22, 29 7757-93-9 Webber MD 1970 solutions N/A Can. J. Soil. Sci. 50:243-253 Comparative effects of oral administration of urea and urea phosphate on the concentrations of dicalcium phosphate and Hemingway RG, Parkins JJ ammonia and urea in the blood of urea phosphate 22, 51 231-826-1 and Ritchie NS 1972 sheep Sheep Br. Vet. J:. 128: dicalcium phosphate stability of dicalcium phosphate dihydrate, octacalcium dihydrate in aqueous solutions and phosphate 22, n/a 7789-77-7 Moreno E.C. Et al 1960 solubility of octocalcium phosphate soils soil. Science soc. Proc: 99-102

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Effects of source of inorganic Dicalcium phosphate, phosphorus and phytase tricalcium phosphate, supplementation on performance, defluorinated rock 7757-93-9 Lee WI, Thacker PA, Han physiological parameters and bone phosphate 22,24 12167-74-7 YK 2010 mineralization in broilers Chicken J Anim Sci Biot. 1(1):15-24 calcium Kim E, Yoo S, Ro HY, Han Environmental Health and Toxicology. 28. 1-7 hydrogenorthophosphate, HJ, Baek YW, Eom IC, Kim Aquatic Toxicity Assessment of Fish, daphnia, Copyright © 2013 The Korean Society of tricalcium phosphate 22,24 7757-93-9 HM, Kim P & Choi K 2013 Phosphate Compounds algae Environmental Health and Toxicology The availability of phosphorus from beta-tricalcium phosphate, 7758-87-4, single and combined phosphates to dicalcium phosphate 23, 22 7757-93-9 Nelson TS and Peeler HT 1961 chicks chicken Poultry Sci 40:1321-1328 tricalcium bis(orthophosphate) (ß- Studies in calcification. 1. the TCP), calcium solubility product of secondary and hydrogenorthophosphate Holt LE, Lamer VK & tertiary calcium phosphate under (DCP) 23, 22 7758.87-4 Chown HB 1925 various conditions n/a Journal of Biological Chemistry: 64: 509-1925 The effects of calcium phosphate hydroxyapatite, beta- 7758-87-4, Ducheyne P, Radin S & ceramic composition and structure Journal of Biomedical materials research. 27: tricalcium phosphate 23, 24 12167-74-7 King L 1993 on in vitro behaviour. I. Dissolution n/a 25-34 beta-tricalcium phosphate Tricalcium phosphate The basic calcium phosphates and 7758-87-4, Eisenberger S, Lehrman A related systems. Some theoretical 23, 24 1306-06-5 and Turner WD 1938 and practical aspects N/A Chem Rev. 26:257-96

The FITR Spectroscopy ans OXDR Slosarczyk A, studies of calcium phosphate based hydroxyapatite, beta- 7758-87-4, Paluszkiewicz C, Gawlicki materials produced from the powder tricalcium phosphate 23, 24 12167-74-7 M & Paszkiewicz Z 1977 precursors with different Ca/P ratios n/a Ceramics international. 23. 297-304 beta-tricalcium phosphate, deflurinated phosphate, 7758-87-4, The biological evaluation of dicalcium phosphate, 23, n/a, n/a, 7757-93- phosphorus compounds. A monocalcium phosphate 22, 21 9, 7758-23-8 Nelson TS and Walker AC 1964 summary. chicken Poultry Sci 43:94-98 Tricalcium phosphate, Dicalcium phosphate, Monocalcium phosphate, Phosphoric acid 24, 22, 21, 48 12167-74-7 Cameron FK and Seidell A 1905 The Phosphates of Calcium I. N/A J AM Chem Soc 27(12): 1503-1512

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested tricalcium phosphate, Toxicity of calcium phosphate to monocalcium phosphate 24, 21 12167-74-4 Majumder S.K., Bano A. 1964 some pests of stored grain insects Nature 202: 1359-1360 tricalcium phosphate, monocalcium phosphate, dicalcium phosphate, monosodium phosphate, disodium phosphate, monopotassium 24, 21, Effect of Various Types of phosphate, dipotassium 22, 2, 3, Satoh SH, Porn-Ngam N, Phosphates on Zinc Availability to phosphate, phosphoric acid 12, 13, 48 12167-74-7 Takeuchi T and Watanbe T 1993 Rainbow Trout fish Nippon Suisan Gakkaishi. 59(8): 1395-1400

Hydroxyapatite, Tricalcium phosphate, Monocalcium phosphate monohydrate, Β- tricalcium phosphate, Dicalcium phosphate dihydrate, Vitreous calcium metaphosphate, Fluorapatite, Potassium Rates of Solution of Calcium calcium pyrophosphate 24, 21, Phosphate in Phosphoric Acid Agricultural and Food Chemistry. 5(4): 266- 23, 22 12167-74-7 Huffman EO et al 1957 Solutions N/A 275

TCP, DCP/DCPA and DCP Calcium phosphates – speciation, dihydrate 24, 22 12167-74-4 Nancollas GH 1979 solubility and kinetic considerations. ACS Symposium 93: 475-497

Raynaud S, Champion E, Determination of calcium/phosphorus hydroxyapatite, beta- Bernache-Assolant and atomic ratio of calcium phosphate tricalcium phosphate, 24, 23 1306-06-5 Laval JP 2001 apatites using x-ray diffractometry N/A J. Am Ceram. Soc. 84(2): 359-366 X-ray Diffraction of calcined bone hydroxyapatite, beta- Balmain N, Legros R and tissue: a reliable method for the tricalcium phosphate 24, 23 12167-74-4 Bonel G 1982 determination of bone Ca/P molar. n/a Calcified Tissue International. 34:S93-S98 Tissue response to implants of tricalcium phosphate, beta- Flatley TJ, Lynch KL and calcium phosphate ceramic in the tricalcium phosphate 24, 23 12167-74-4 Benson M 1983 rabbit spine Rabbit Clinical orthop Rel Res. 179: 256-252

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G.D. Webler, M.J.M. Characterization and evaluation of Zapata, L.C. Agra, E. cytotoxicity of biphasic calcium Barreto, A.O.S. Silva, J.M. phosphate synthesized by a solid Current Applied Physics. DOI: HAP/ β-TCP mix (various ratios) 24/23 1306-06-5 Hickmann, E.J.S. Fonseca 2014 state reaction route cells 10.1016/j.cap.2014.03.026 DICALCIUM PYROPHOSPHATE, SODIUM METAPHOSPHATE rate and mechanism of its hydrolytic INSOLUBLE 26, 11 7790-76-3 Huffman E.O and Fleming J.D.1960 degradation . J. Phys. Chem. 64:240-244 Chow L.C., Takagi S., dicalcium pyrophosphate, Effect on whole saliva of chewing Shern R.J., Chow T.H., monocalcium phosphate, 26, 21, gums containing calcium Journal of dental research.73,26-32. Takagi K.K and Sieck B.A tetracalcium phopshate. 22, 7790-76-3 1994 phosphates. human http://jdr.sagepub.com/cgi/reprint/73/1/26.pdf calcium pyrophosphate, Polyphosphate Hydrolysis of ammonium pyrophosphate, Ammonium, calcium and calcium calcium ammonium 26, n/a, Hossner L.R. And Melton ammonium pyrophosphates in pyrophosphate n/a 7790-76-3 J.R. 1970 selected Texas soils soil soil sci soc amer proc 34: 802-805 iron phosphate, aluminium The action of water and saline phosphate, tricalcium solutions upon certain slightly soluble The Journal of The American Chemical phosphate, 27, 40, 24 10045-86-0 Cameron FK and Hurst LA 1904 phosphates. N/A Society. 26(8): 885- 913. Dimagnesium phosphate, Ferric phosphate The Phosphates of Magnesium and 29, 27 7757-86-0 Cameron FK and Bell JM 1907 Iron N/A J Phys Chem 11(5): 363-368

MgHPO4.3H2O (newberite) Mg3(NH4)2(HPO4)4.8H2O Mg3(NH4)2(HPO4)2.4H2O –A (Schertelite) Mg3(NH4)2(HPO4)2.4H2O –B MgNH4PO4.6H2O (struvite) 29, 30, Frazier AW and Waerstad The phase system MgO-(NH4)2O- 31, 60 7757-86-0 KJ 1992 P2O5-H2O at 25°C. N/A Ind Eng Chem Res, 31: 2065-2068

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested disodium hydrogenorthophosphate, dipotassium 7558-79-4, hydrogenorthophosphate 3, 13 7758-11-4 Ravich MI and Popova ZV 1942 ? N/A Izv Akad Nauk SSSR. ?:268-273 Bernstein D.S, Newton R. The effect of oral sodium phosphate disodioum phosphate, on the formation of renal calculi and monosodium phosphate 3, 2, 7558-79-4 1966 on idiopathic hypercalcuria. The Lancet. Nov. 19:1105-1107 disodium phosphate, calcium phosphate monobasic, calcium Further observations on the phosphate dibasic 3, 21, 22 7558-79-4 McClure F.J and Muller A. 1959 cariostatic effects of phosphates Rats J. D. Res. 38(4): 776-781 the cariostatic effect in white rats of Na2HPO4, calcium phosphorus and calcium phosphate monobasic, supplements added to the flour of calcium phosphate dibasic 3, 21, 22 7558-79-4 McClure F.J. 1960 bread formulas and to bread diets Rats J. Nutrition 72: 131-136

High phosphorus intakes acutely and Mixture of disodium negatively affect Ca and bone phosphate and trisodium 7558-79-4 Kemi VE, Karkkainen & metabolism in a dose-dependent phosphate (P content 25%) 3, 4 7601-54-9 Lamberg-Allardt JE 2006 manner in healthy young females Man British Journal of Nutrition: 96: 545-552 sodium phosphate (Na2HPO4), trisodium phosphate, sodium acid pyrophosphate, trisodium trimetaphosphate (3- hydrate), sodium metaphosphate, sodium hexametaphosphate, monopotassium phosphate, potassium Antibacterial action against pyrophosphate, potassium 3, 4, 5, 8, streptococuss mutans and inhibitory polyphosphate (add. Non- 9, 10, 12, effect on the experimental Hamster ip substances) 15, 17 7558-79-4 Shibata H 1981 caries of condense phosphates bacteria Fukuoka Igaku Zasshi 6:379-391 disodium phosphate dodecahydrate, Nofre C., Dufour H. and compared toxicity of 32 mineral comptes rendus des sceances de l'academie phosphoric acid, 3, 48 7558-79-4 Cier A. 1963 anions in the mice mice des sciences 257: 791-794

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested disodium phosphate, sodium acid pyrophosphate, tetrasodium pyrophosphate, sodium factors affecting sensitivity of metaphosphate, sodium 3, 5, 7, 9, Staphylococcus aureus 196E to applied and environmental microbiology: 842- tetrametaphosphate n/a 7558-79-4 Jen C.M.C, Shelef L.A. 1986 polyphosphates bacteria 846 disodium phosphate, sodium pyrophospate (TSPP?), sodium Some effects of different phosphate tripolyphosphate, sodium 3, 5/7, 0, Mahoney AW & Hendricks compounds on iron and calcium JOURNAL OF FOOD SCIENCE- Vol. 43, No. metaphosphate 10 various DG 1978 absorption rats 5: 1471-1476 disodium hydrogenphosphate, 7558-80-7, Uber verbindungen von tetrasodiumpyrophosphate, 7722-88-5, alkaliphosphaten mit monopotassium phosphate 3, 7, 12 7778-77-0 Menzel VH and Gabler C 1929 wasserstoffperoxyd N/A Z Anorg Chem. 177:187-198 disodium phosphate, tetrasodium pyrophosphate, trisodium trimetaphosphate, Effects of dietary phosphate diammonium phosphate, 3, 7, 8, Van Reen R. and Ostrom supplements on dental caries in the calcium phosphate dibasic 19, 22 7558-79-4 C.A. 1962 rat Rats J. D. Res 41: 875-882 disodium phosphate (DSP), tetrasodium polyphosphate, grahams salt, potassium dihydrogen Research into the toxicity and effects Amoeba and orthophosphate, calcium of polyphosphates on growth of rotifer and phosphate monobasic, 3, n/a, 9, cultures of amoeba, rotifers, Amphibian calcium phosphate tribasic, 12, 21, tadpoles, and on the succession of (Bufo bufo and institut fur Landwirtschaftliche Zoologie und iron pyrophosphate 24, 28 7558-79-4 Wuembach et al 1966 organisms in cellulose decomposition Xenopus laevis) bienenkunde, Report 33 pages disodium phosphate, sodium acid pyrophosphate, sodium hexametaphosphate, 3,5, 10, effects of some phosphates in a short- phosphoric acid 48 7558-79-4 Konig K.G. Et al 1961 period rat caries experiment Rats Arch. Oral biol. 3: 258-270

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Magnesium hydrogen phosphate prepared at the 26th JECFA (1982) trimagnesium phosphate, published in 1982 and 1992. potassium tripolyphosphate 30, 16 7757-87-1 63rd JECFA 2004 Revised at the 63rd JECFA (2004). n/a n/a Trimagnesium phosphate prepared at the 17th trimagnesium phosphate, JECFA (1973) published in 1978 and 1992. trisodium phosphate 30, 4 7757-87-1 57th JECFA 2001 JEFCA N/A Revised at the 57th JECFA (2001). Manganese phosphate' Blumberg H, Shelling DH, The production of manganese rickets identity not defined 33,34,35 Jackson DA 1938 in rats rat The journal of nutrition, 16(3): trisodium phosphate, Bucher k., Bucher K.E., The topically irritant substance: monosodium phosphate 4, 2 7601-54-9 Walz D. 1981 Essentials-bio-test-predictions. Agents and actions, 11(5): 515-519 trisodium phosphate, Simon I. monosodium phosphate Minimal Lethal Dose of some Sodium 4, 2 7601-54-9 1939 Salts Injected Intravenously. Boll Soc Ital Biol Sper, 14():136-137 Abderhalden E. Handbuch der biologischen Arbeitsmethoden: Chemische und physikalische trisodium phosphate, 7601-54-9, Untersuchungsmethoden der disodium phosphate 4, 3 7758-79-4 1935 Pharmakologie und Toxikologie. ? 4: 1382 - 1383 trisodium phosphate, Studien an alkaliphosphaten und disodium 7601-54-9, arsenaten II): Tertiares hydrogenorthophosphate 4, 3 7758-79-4 Menzel 1937 natriumphosphat N/A Ztschr. Elektrochem. 43 (2): 104- trisodium phosphate anhydrous, sodium acid pyrophosphate, tetrasodium pyrophosphate, ABSTRACT: Dermal toxicity/ skin tripotassium phosphate, 4, 5, 7, irritation studies on five inorganic monocalcium phosphate 14, 21 7601-54-9 Weiner M. et al 1987 phosphates Rabbits ? trisodium phosphate anhydrous, sodium acid pyrophosphate, tetrasodium pyrophosphate, tripotassium phosphate, 4, 5, 7, ABSTRACT: Eye irritation studies on monocalcium phosphate 14, 22 7601-54-9 Weiner M. et al 1986 five inorganic phosphates Rabbits ?

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested trisodium phosphate, sodium acid pyrophosphate, trisodium trimetaphosphate, sodium Pharmacology of the meta hexametaphosphate 4, 5, 8, 10 7758-16-9 Behrens B. and Seelkopf K. 1933 phosphoric acids mice arch exp path pharmak 169():238 trisodium phosphate, Bell R.N. Estimation of triphosphoric and tetrasodium pyrophosphoric acids: In the pyrophosphate, sodium presence of ortho- and hexametaphosphates 4, 7 , 10 7758-16-9 1947 metaphosphoric acids. n/a Anal. Chem. 19:97-100 Observations on the effect of trisodium phosphate, intravenous injections of sodium Journal of Pharmacology and Experimental monosodium phosphate 4,2 Greenwald I 1915 phosphate rabbit, dog Therapy. 7: 57-61 trisodium phosphate, Irani R.R. and Callis C.F. tetrasodium pyrophosphate, sodium metaphosphate insoluble, tetrapotassium Calcium and magnesium pyrophosphate, sodium 4,7, 11, sequestration by sodium and Journal of the American Oil Chemists' tripolyphosphate 15, 0 7601-54-9 1962 potassium polyphosphates. n/a Society. March: 156-159 Aluminium Hanawa T, Kaga M, Itoh Y, orthophosphate, Echizenya T, Oguchi H and Cytotoxicities of oxides, phosphates hydroxyapatite 40, 24 7784-30-7 Ota M 1992 and sulphides of metals. N/A Biomaterials. 13(1): 20 – 24 aluminium phosphate, iron A study of dust toxicity using a British Journal of Industrial Medicine. 13: 187- phosphate 40, 27 7784-30-7 Marks J et al 1956 quantitative tissue culture technique. N/A 191 aluminium phosphate, Etudes physico-chemiques de magnesium hydrogen AlPO4, de MgHPO4.3H2O et leurs Acta Poloniae Pharmaceutica- Drug Research. phosphate 40, 29 7784-30-7 Boudraa M’hamed et al 1991 melanges. N/A 48(3-4): 63-68 Aluminium orthophosphate dihydrate, hydroxyapatite, dicalcium phosphate dihydrate, Iron 40. 24, Lindsay WL and Moreno orthophosphate dihydrate 22, 27 7784-30-7 EC 1960 Phosphate phase equilibria in soils N/A Soil sci soc Am J. 24(3):177- 182 245-490-9, Orthophosphoric acid, 233-782-9, Researches on the arsenates, pyrophosphoric acid, 231-633-2, phosphates and modifications of Alembic Club, London Agents Simpkin, metaphosphoric acid 45, 48, 50 219-574-0 Graham T 1833 phosphoric acid Marshall, Hamilton, Kent & Co Ltd (1904)

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested sodium potassium polyphosphate, trisodium the hydrolyse of condensated trimetaphosphate 46, 8 24315-83-1 Thilo E. and Wieker W. 1959 phosphates in aqueous solution water Naturwissen, 46:367-373 Fisher AA disodium fluorophosphate, monoammonium Contact Dermatitis From Foods and phosphate, monosodium Food Additives. 582-594 and Contact Dermatitis Third edition Lea & Febiger phosphate 47, 18, 2 10163-15-2 1986 851,855 and 904 Philadelphia 1986 Phosphoric acid, Graham’s salt The system zinc oxide, phosphorous 48, 11 7664-36-2 Eberly NE et al 1920 pentoxide and water at 25° and 37° N/A J Am Chem Soc, 42(7): 1433-1439 Phosphoric acid, Potassium dihydrogenorthophosphate, Tripotassium orthophosphate, Ammonium dihydrogenorthophosphate, Diammonium hydrogenorthophosphate, The ternary systems, Potassium – Triammonium phosphate 48, 12, Phosphoric acid – Water and 14, 18, 19 7664-38-2 Parker EG 1914 Ammonia – Phosphoric acid – Water N/A J Phys Chem, 18: 653-661 phosphoric acid, monoammonium Polyphosphoric acids and their phosphate 48, 18 7664-38-2 Kubasova L V 1971 ammonium salts. Russian Chemical Reviews, 40 (1) 1 - 12. phosphoric acid, diammonium phosphate, sodium acid Ortho Vs. Poly. Author takes a look pyrophosphate, sodium 48, 19, 5, at the history and behaviour of ortho tripolyphosphate 0 7664-38-2 Lohry R 2001 and polyphosphates. Fluid Journal N/A Fluid Journal phosphoric acid, monocalcium phosphate, sodium Toxicology of the eye, Second Edition. Charles hexametaphosphate 48, 21, 10 7664-38-2 Grant W M, . 1974 Toxicology of the Eye (Handbook) rabbit C Thomas USA phosphoric acid, Ravindran V, Kornegay ET, An Evaluation of Various Response monocalcium phosphate Potter LM, Ogunabameru Criteria in Assessing Biological monohydrate, dipotassium BO, Welten MK, Wilson JH Availability of Phosphorus for phosphate 48, 21, 22 7664-38-2 and Potchanakorn M 1995 Broilers chicks Poultry Science. 74: 1820-1830

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Ibrahim S, Fisher C, El Improvement of the nutritional quality phosphoric acid, dicalcium Alaily H, Soliman H and of Egyptian and Sudanese sorghum phosphate 48, 22 7664-38-2 Anwar A 1988 grains by the addition of phosphates chicks British Poultry Science. 29: 721-728 Phosphoric acid, iron The system ferrous oxide-phosphoric phosphate Carter SR and Hartshorne acid-water and some of its oxidation 48, 27 7664-36-2 NH 1926 products N/A ? phosphoric acid, trisodium orthophosphate 48, 4 7664-38-2 Young JR et al 1988 classification without testing N/A Toxic in vitro, vol 2, no 1, pp 19-26, 1988 Measure of photosynthesis and of orthophosphoric acid, Beranger-Yvon. A., growth, Chlorella alga (8 days algae (chlorella revue de cytologie et de biologie vegetale (19): pyrophosphoric acid 48, 50 7664-38-2 Champighy M.L., Guyon D. 1958 culture) pyrenoidosa) 433-452 Bloch-Frankenthal L. The role of magnesium in the hydrolysis of sodium pyrophosphate Sodium pyrophosphate 5 (OR 7) 7758-16-9 1954 by inorganic pyrophosphatase. rat (blood) Biochem J. 57,1: 97-92 cytogenetic effects of inorganic Natarajan A.T. And pyrophosphate and 5-fluoro plant (vicia sodium pyrophosphate 5 (OR 7) 7758-16-9 Ahnsrom G. 1968 deoxyuridine faba) Hereditas 59 (2-3): 229 Sodium pyrophosphate 5 (OR 7) 7758-16-9 Salzer 1894 ? N/A Arch Pharm 232: 365-375 sodium acid pyrophosphate / sodium Effect of some chemicals used in oil diverse marine pyrophosphate 5 / 7, 7758-16-9 Daugherty F.M. 1951 well drilling on marine animals invertebrates sewage ind. Wastes 23: 1282-1287 Sodium pyrophosphate (SAPP or TSPP) 5 or 7 7758-16-9 Bayer KJ 1869 1) Chemische Notizen N/A J Prakt Chem, 106: 501 Cumulative toxicities of some inorganic salts to daphnia magna as determined by median tolerance Sodium pyrophosphate 5, 7758-16-9 Dowden B 1961 limits Daphnia Proc La Acad Sci, 23: 77-85 Inhibition of Clostridium sporogenes PA 3679 and Natural Bacterial Flora of Cooked Vacuum-Packaged Bratwurst by Sodium Acid Pyrophosphate and Sodium sodium acid Molins RA, Kraft AA, Olson Tripolyphosphate With or Without pyrophosphate, sodium DG, Walker HW & Added Sodium Nitrite tripolyphosphate 5, 0 7758-16-9 Hotchkiss DK 1986 bacteria Journal of Food Science. 51(3): 726-731

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested sodium acid pyrophosphate, potassium dihydrogenphosphate, tetrapotassium 7758-16-9, pyrophosphate, 7778-77-0, monocalcium phosphate, 7320-34-5, calcium dihydrogen 7758-23-8, No 264. Etude des polyphosphates pyrophosphate, calcium 5, 12, 15, 14866-19-4, de sodium, potassium et calcium. II. pyrophosphate 21, 25, 26 7790-76-3 Morin C 1961 Etude des polyphosphates de sodium N/A Bull. Soc. Chim. France: 1719-1740 sodium acid phosphate, Boyd, E.M., Seymour untoward and toxic reaction of a Experimental Medecine and Surgery (4):223- monosodium phosphate 5, 2 7758-16-9 K.G.W. 1946 range of different products rats 227 sodium acid Dowden B F and Bennett H invertebrates pyrophosphate, J. (various monosodium Toxicity of selected chemicals to dependent on pyrophosphate 5, 2 7758-16-9 1965 certain animals substance) j wpcf.37.1308-1316 The effect of the intravenous sodium biphosphate and administration of phosphate solutions sodium phosphate mixture 5, 2 (?) 7758-16-9 Greenfield I 1941 in normal rabbits rabbits J. Lab. Clin. Med. 7:68-70 sodium acid Sutton C.D. and Larsen S. pyrophosphate, disodium Pyrophosphate as a source of phosphate 5, 3 7758-16-9 1964 phosphorus for plants. n/a Soil Sci. 97(): 196-201 sodium acid Firstenberg-Eden R et al pyrophosphate, trisodium Inhibition of Moraxella-Acinetobacter phosphate, sodium Cells by Sodium Phosphates and tripolyphosphate 5, 4, 0 7758-16-9 1981 Sodium Chloride. Journal of Food Science 46: 579-582 sodium acid pyrophosphate, cementum: a phosphate-sensitive pyrophosphoric acid 5, 49 7758-16-9 Nociti F.H. Et al 2002 tissue rats (mutant) J. D. Res. 81(12): 817-821 the hydrolysis of the condensed phosphates. II a) the role of the hydrogen ion in the hydrolysis of sodium pyrophosphate. II b) the sodium pyrophosphate, McGilvery J.D. And dissociation constants of pyrophosphoric acid 5, 50 7758-16-9 Crowther J.P. 1954 pyrophosphoric acid soil canadian J chem. 32: 174-185 Pyrophosphoric acid, 7758-16-9, Studies in cotton seed meal sodium pyrophosphate 5, 50 2466-09-3 Withers WA and Ray BJ 1913 intoxication I: Pyrophosphoric acid Journal of Biological Chemistry, XIV(2): 53-58

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Effect of Acid and Neutral disodium Marcy JA, Kraft AA, Pyrophosphates on the Natural dihydrogenpyrophosphate, Hotchkiss DK, Molins RA, Bacterial Flora of a Cooked Meat trisodium hydrogen Olson DG, Walker HW and System diphosphate 5, 6 7758-16-9 White PJ 1988 bacteria JOURNAL OF FOOD SCIENCE. 53(1): 28- 30

Potassium polyphosphate (Kurrol salt) mixture 2/3 tetrasodium pyrophosphate (TSPP) 1/3 disodium Van Esch GJ, Vink HH, Wit the physiological effect of pyrophosphate (SAPP) 5, 7 7758-16-9 SJ, Van Genderen H 1957 phosphates Mouse Arzneimittel-forsch 7():172-175

Marcy JA, Kraft AA, Effect of Acid and Alkaline disodium Hotchkiss DK, Molins RA, Pyrophosphate Blends on the Natural dihydrogenpyrophosphate, Olson DG, Walker HW and Flora of a Cooked Meat System tetrasodium pyrophosphate 5, 7 7758-16-9 White PJ 1988 bacteria JOURNAL OF FOOD SCIENCE. 53(1): 25-27 Boettge K., Jaeger K.H. sodium acid and Mittenzwei H. Das Adenylsäuresystem: neure pyrophosphate, ergebnisse und probleme. tetrasodium pyrophosphate 5, 7 7758-16-9 1957 Arzneimittel-Forschung. Drug Research. 7:24-59 sodium pyrophosphate, ABSTRACT: Effects of condensed sodium metaphosphate, phosphates as a food additive on the sodium liver, Kidneys, muscles, and bones of hexametaphosphate 5, 9, 10 7758-16-9 Omoto M. et al 1986 the mouse mice toxicology lett suppl 31: P1-54 sodium acid pyrophosphate, sodium tripolyphosphate, sodium hexametaphosphate, sodium polyphosphate, Seward RA, Lin CF & heat sensitisation of Salmonella by calcium polyphosphate. 5, 9, 10, 7758-16-9 Melanchoris N 1986 polyphosphate bacteria Journal of food science. 51(2): 471-473

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested sodium pyrophosphate, sodium metaphosphate, sodium hexametaphosphate, tetrapotassium pyrophosphate, potassium Mutagenicity test of food additives metaphosphate, dicalcium 5, 9, 10, with salmonella typhimurium TA97 ann. Rep. Tokyo Metr. Res. Lab. P.H. 41: 315- phosphate 15, 17, 22 7758-16-9 Fujita H. and Sasaki M. 1990 and TA102 bacteria 322 sodium acid pyrophosphate, Bactericidal and Bacteriolytic Effects tetrasodium of Selected Food-Grade Phosphates, pyrophosphate, sodium Lee RM, Bartami PA, Olson Using Staphylococcus aureus as a Journal of Food Protection, Vol. 57, No. 4, tripolyphosphate 5,7,0 7758-16-9 DG & Wiliams FD 1994 Model System Bacteria Pages 276·283 Phosphorous Properties of the 50, 48, 8, Element and Some of Its Tennessee Valley Authority Chemical 11, 17, Compounds. By the Staff of the Engineering Report No. 8 Various 22, 21 Various Farr TD 1950 Division of Chemical Engineering. N/A

50, 49, 48, 47, 11, 10, 9 (all ortho- ,pyro-, tri- phosphate s, 0, 5, 7, 8, 10, 11, 47, 48, Various 49, 50) Various Audrieth 1950 TEXTBOOK n/a Inorganic syn theses Volume III: 85-117 polyphosphoric acid, The effects of polyphosphoric acid magnesium and inorganic salts upon the hydrogenorthophosphate, respiration of Ehrlich Ascites Tumor sodium metaphosphate 51, 29, 9 8017-16-1 Ohta. M 1961 Cells tumor cells Nihon Univ J. Med. 3: 365-385 WHO FOOD ADDITIVES SERIES: 67: Safety evaluation of prepared by the Seventy-sixth meeting of the Magnesium dihydrogen certain food additives Joint FAO/WHO Expert Committee on Food diphosphate 57/58 20768-12-1 JEFCA 2012 n/a Additives (JECFA) World Health Memorie della Reale Academia delle scienze sodium pyrophosphate 7 (or 5) Sabbatani L 1904 Funzione Biologica del Calcio ? di Torina 54(2a):459-529

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Uber die pharmakologische wirkung various: sodium kalziumfallender sauren und der Archiv fur experimentelle Pathologie und pyrophosphate 7 (or 5) Starkenstein E 1914 magnesium salze rabbit Pharmakologie ixxvii: 45-82 The chemical news –Sodium Sodium pyrophosphates 7 or 5 7722-88-5 ? 1928 pyrophosphates N/A The mechanism of hydrolysis of polyphosphates. V.the effect of sodium pyrophosphate, 7722-88-5, Watanabe M, Matsuura M cations on the hydrolysis of pyro- and Bulletin of the Chemical Society of Japan. Sodium tripolyphosphate 7(or 5), 0 7758-29-4 and Yamada T 1981 triphosphates N/A 53(3): 738-741 sodium pyrophosphate, Uber die hydrolysegeschwindigkeit STPP ,sodium 7(or 5), 0, von pyrophosphate, tripolyphosphat hexametaphosphate 10 7722-88-5 Watzel VDR 1942 und hexametaphosphat. N/A Die Chemie. 55(47/48): 351-366 Sodium pyrophosphate Soluble crystalline polyphosphates – Sodium triphosphate their purification, analysis and The Journal of Physical Chemistry, 58(8): 603- Sodium tetraphosphate 7, 0, 7722-88-5 Quimby OT 1954 properties. N/A 618 sodium pyrophosphate, sodium tripolyphosphate, microorganism sodium Sensitivity of Pseudomonas strains s; hexamaetaphosphate 7, 0, 10 7722-88-5 Zessin KG and Shelef LA 1988 to polyphosphates in media system pseudomonas Journal of Food Science. 53(2):669-670 tetrasodium Fingerhut M et al pyrophosphate, sodium Zur Frage Der Resorption von tripolyphosphate, sodium polyphosphaten (On the question of polyphosphate 7, 0, 9 7722-88-5 1965 absorption of polyphosphates) rat D. Jolley, W. Maher & P. Rapid Method for Separating and tetrasodium Cullen Quantifying Orthophosphate and pyrophosphate, disodium Polyphosphates:Application to phosphate 7, 2 7722-88-5 1998 Sewage Samples. n/a Water Research Vol. 32, No. 3, pp.711-716 tetrasodium Heitkemper DT, Kaine LA, pyrophosphate, disodium Jackson DS and Wolnik Determination of tripolyphosphate phosphate, sodium KA, and related hydrolysis products in tripolyphosphate 7, 2, 0 7722-88-5 ? processed shrimp, n/a US FDA. pp 92-100. tetrasodium pyrophosphate, disodium orthophosphate, calcium The physiological action of some sodium phosphate, 7, 3 7722-88-5 Gardner J and Symes W 1911 camphene phosphonates of sodium rat Biochemical Journal. 5: 390 tetrasodium pyrophosphate, trisodium effects of synthetic detergents on phosphate 7, 4 7722-88-5 Smith R.S. Et al 1956 water coagulation water j am wat wks ass 48: 55-69

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested tetrasodium Friedrich Kiermeier & Zusammenfassende pyrophosphate, trisodium Klement Möhler Übersichtsberichtsberichte: Zure phosphate, disodium Verwendung der Polyphosphate bei phosphate, monosodium Lebensmitteln. Z. Lebensmittel- phosphate 7, 4, 3, 2 7722-88-5 1957 Unters. U. -Forsch., Rand 106 ? ? 41st JECFA Tetrasodium pyrophosphate prepared at the 41st JECFA publisehd in 1993, superceding tetrasodium specifications prepared at the 37th pyrophosphate, sodium JECFA, publisehd in 1992. Revised acid pyrophosphate 7, 5 7722-88-5 1993 at the 55th JECFA (2000). n/a JEFCA tetrasodium Lebron CI, Molins RA, Inhibi'tion of Growth and Aflatoxin pyrophosphate, sodium Walker HW, Kraft AA, Production of Aspergilli in Medium polyphosphate 7, 9 7722-88-5 Stahr HM 1989 Containing Phosphates yeat Journal of Food Protection, Vol. 52(1): 4-6 Tetrasodium pyrophosphate, sodium 7722-88-5, acid pyrophosphate, 7758-16-9, trisodium pyrophosphate, 14691-80-6, Crystallographic data on some dicalcium pyrophosphate 7,5,6,26 7790-76-3 Corbridge DEC 1957 hypophosphates and pyrophosphates N/A Acta Cryst. 10: 85 sodium trimetaphosphate, The mechanism of the hydrolysis of sodium condensed phosphates. III. The tetrametaphosphate, 7785-84-4, Watanable M, Sato S and mechanism of the hydrolysis of Bulletin of the Chemical Society of Japan sodium tripolyphosphate 8, 0 7758-29-4 Saito H 1975 trimeta- and tetrametaphosphates N/A 48(12): 3593-3597 Mitchell L C A paper chromatogragphic study of sodium trimetaphosphate, the effect of synthetic digestive fluids sodium on the sodium salts of Tri-, Tetra-, hexametaphosphate 8, 10 7785-84-4 1958 and Hexametaphosphoric acids. n/a? Journal of the A. O. A. C, 41, 185-188. Lanigan Final report on the safety assessment of sodium sodium trimetaphosphate, metaphosphate, sodium sodium trimetaphosphate and sodium hexametaphosphate 8, 10 7785-84-4 2001 hexametaphosphate. International Journal of Toxicology. trisodium trimetaphosphate, ABSTRACT: Effect of CaHPO4 and monocalcium phosphate 8, 21 7785-84-4 Koulourides T. 1974 TMP on carcigonicity in Human bovine enamel J. D. Res. 53: 606

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested sodium trimetaphosphate, Dionex. tetrasodium pyrophosphate, disodium Determination of polyphosphates phosphate, sodium using ion chromatography with Dionex analysis condensed phosphates tripolyphosphate 8, 7, 3, 0 7785-84-4 2002 suppressed conductivity detection. n/a 2002.pdf sodium trimetaphosphate influence on the early development of rat 8, caries and concurrent microbial sodium trimetaphosphate [35] 7785-84-4 Henry C. and Navia J. 1969 changes Rats Caries Res. 3: 326-338 sodium polyphosphate, 68915-31-1, Ion-exchange chromatographic sodium tripolyphosphate, 7758-29-4, Matsuura N, Lin T and analysis on the chain length of Bulletin of the Chemical Society of Japan. 43: tetrasodium pyrophosphate 9, 0, 7 7722-88-5 Kobayashi Y 1970 polyphosphate products N/A 2850-2858 sodium metaphosphate, sodium hexametaphosphate, Further studies on the cariostatic potassium metaphosphate, 9, 10, 17, effect of organic and inorganic calcium phosphate dibasic 22 68915-31-1 McClure F.J. 1963 phosphates Rats J. D. Res. 42(2): 693-699 sodium hexametaphosphate, potassium metaphosphate 9, 17 68915-31-1 Lang K. et al 1955 the metabolism of polyphosphates rats Biochemische Zeit. 327: 118-125

extracellular release of enzymes from macrophages in vitro for measuring sodium metaphosphate, cellular interaction with particulate mammalian dicalcium phosphate 9, 22 10124-56-8 Lock S.O. Et al 1987 and non-particulate materials cells Toxic. In vitro 1(2): 77-83

Separation of synthetic inorganic polymers of condensed phosphates sodium metaphosphate, by capillary gel electrophoresis with sodium trimetaphosphate 9, 8 10124-56-8 Wang T and Li SFY 1998 indirect photometric detection. n/a Journal of Chromatography A, 802:159-165 The effect of 0.05 per cent dietary sodium fluoride n/a n/a Pindborg J 1957 sodium fluoride on the rat kidney rat Acta pharmacol et toxicol. 13:36-45 Sodium fluoride promotes morphological transformation of sodium fluoride n/a n/a Jones CA et al 1988 Syrian Hamster embryo cells. hanster Carcinogenesis 9(12): 2279-2284 Fluorine from rock phosphate N/A N/A Zumpt I 1975 Chronic flouride poisoning in sheep Sheep J S Afr Vet Ass, 46: 161-163

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Various N/A N/A Molins RA Phosphates in Food (handbook) Various N/A Integrated risk information system. ReferenceDoseForChronic Http://www.epa.gov/iris/subst/0697.ht phosphorus N/A N/A OralExposure m Uber die Beeinflussung von Daphnia Sodium potassium magna durch einige Salze und Kungl Fysiografiska Sallskapets I Lung phosphate N/A N/A Nanmann E 1933 Salzmischungen Daphnia Forhandlingar Bd 4, Nr 2

Contact uptake of metal compounds and their molluscicidal effects on the Iron (III) pentandenionate slug, Deroceras reticulatum (Muller) Iron (III) diazaalkanolate N/A N/A Bullock JI et al 1992 (Pulmonata: Limacidae) Slug Crop protection, 11: 329-334 Fire Retardants and Ecological effects of fire fighting Conference Proceedings, Australian Bushfire Firefighting Foams N/A N/A Adams R and Simmons D 1999 foams and retardants. N/A Conference, Albury July 1999 Hydrolysis of condensed phosphates Calcium metaphosphate N/A 77489-25-9 Allmaras R.R. 1965 in soils soil soil science soc proceedings 487-488 the toxicity thresholds of various substances found in industrial wastes as determined by the use of daphnia daphnia No IP substances studied N/A N/A Anderson BG 1944 magna magna. Sew Works J. 16(6):1156-1165 Arlauskas A, Baker RSU, No IP substances Bonin AM, Tandon RK, investigated N/A N/A Crisp PT and Ellis J 1985 Mutagenicity of metal ions in bacteria Environmental Research. 36: 379-388 Averbuch-Pouchot and ultraphosphates N/A N/A Durif A 1992 Crystal Chemistry of Ultraphosphates n/a Zeeitschrift fur Kristallographic 201: 69-92 Studies of Phosphates. Part II. Orthophosphates of the type M3(PO4)2,XH2O. 871-882 Ammonium magnesium Part IV. Pyrophosphates of some phosphate along with a bivalent metals and their double number of other salts, and solid solutions with sodium Bassett & Bedwell Studies of Phosphates I - IV phosphates N/A N/A Bassett H and Bedwell WL 1933 pyrophosphates. 1412-1429 and 871-882 No IP substances Bautista EM and Alexander Reduction of inorganic compounds microorganism evaluated N/A N/A M 1972 by soil microorganisms. s Soil Sci Soc Am J. 36(6) Hydrolytic degradation of Sodium and potassium polyphosphates in liquid detergent polyphosphate N/A N/A Bennet et al 1957 formulations N/A Soap and Chem Spec 33: 44-47

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Comparative toxicity of No IP substances Biesinger KE, Lemke AE, polyelectrolytes to selected aquatic investigated N/A N/A Smith WE and Tyo RM 1976 animals. fish J Water Pollut Control Fed. 48(1):183-187 Amorphous calcium metaphosphate as a phosphorous supplement for white leghorn Calcium metaphosphate N/A 77489-25-9 Bird HR, Caskey CD 1943 chicks chickens Poultry Sci. 22:333-334 Toxicity of chemical fire retardants to juvenile coho salmon and rainbow Diss Abstr Int B Sci Eng - phD thesis Univ Unknown N/A N/A Blahm TH 1979 trout Fish Idaho, ID 40, 39(9): 4115 Effect of Chemical Fire Retardants Phos-Chek XA, Fire-Trol on the Survival of Juvenile National Marine Fisheries Service 931 N/A N/A Blahm TH and Snyder GR 1973 Salmonids. N/A Environmental Facility Prescott, Oregon. Toxicite apparentte de certain engrais phosphates et intoxication manganique induite. Journee Unknown N/A N/A Boyer J 1980 Georges Aubert. ? ?

Fire-Trol GTS-R, Fire-Trol Acute Toxicity of Fire-Retardant and LCG-R, Phos-Chek WD- Foam-Suppressant Chemicals to 881 and Ansul Silv-Ex and Early Life Stages of Chinook Salmon Environmental Toxicology and Chemistry, Phos-Check D75-R N/A N/A Buhl KJ and Hamilton SJ 1998 (Oncorhynchus tshawytscha) Fish 17(8): 1589-1599 Fire-Trol LCA-F, Fire-Trol LCM-R and Phos-Chek 259F, FireFoam 103B, FireFoam 104, Fire Quench, ForExpan S, Acute Toxicity of Fire-Control Pyrocap B-136 and other Chemicals, Nitrogenous Chemicals Transactions of the American Fisheries chemicals. N/A N/A Buhl KJ and Hamilton SJ 2000 and Surfactants to Rainbow Trout. Fish society. 129: 408-418 Buscemi DM, Hoffman DJ, Effects of Phos-Chek G75-F and Silv- Phos-Chek G75-F and Silv- Vyas NB, Spann JW and Ex on red-winged blackbird (Agelaius Ex N/A N/A Kuenzel WJ 2007 phoeniceus) embryos. Birds Environmental Pollution, 148: 312-315

Buscemi DM, Hoffman DJ, Effects of Phos-Chek G75-F and Silv- Phos-Chek G75-F and Silv- Vyas NB, Spann JW and Ex on Developing Northern Bobwhite Ex N/A N/A Kuenzel WJ 2002 Quail (Colinus virginianus) Birds Erch Eviron Contam Toxicol 43: 330-337

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

The solubility of calcium sulphate in No phosphates N/A N/A Cameron FK and Brown BE 1905 solutions of other salts N/A J Phys Chem 9(3): 210-215 Chaurasia LC anf Rahtor Mitotic effects of superphosphate on superphosphate N/A N/A JS 1980 somatic cells of Allium sativum plants Sci Cult, 46: 150-152 Chaurasia OP and Sinha Cytogenic effects of single super Perspectives in cytology and genetics, 5: 349- Single super phosphate N/A N/A Sp 1986 phosphate on onion root tip cells. plants 352 Induction of Mitotic-Chromosome Chaurasia OP and Sinha Anomalies in Mice by Single Super Single Super Phosphate N/A N/A SP 1988 Phosphate Mice Cytologia, 53: 485-489

The Structural Chemistry of American Elsevier Publishing Company, Inc. Phosphorous N/A N/A Corbridge DEC 1974 Phosphorus. N/A ISBN: 0-444-41073-2

Accidental superphosphate fertiliser SUPERPHOSPHATE N/A N/A East NE 1993 poisoning in pregnant ewes. sheep JAVMA. 203(8): 1176-1177 Increased Incidence of Fractures in Middle-aged and Elderly Men with Unspecified N/A N/A Elmstahl S et al 1998 low intakes of phosphorus and zinc human Osteoporos Int 8:333-340 The Chemistry of Phosphorus. Environmental, organic, inorganic, biochemical and spectroscopic Phosphorous N/A N/A Emsley J and Hall D 1976 aspects. N/A John Wiley and Sons. ISBN: 0-470-23869-0

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Phosphorous trichloride, phosphorous pentachloride, EPA Summary review of health phosphorous oxychloride, effects associated with elemental and phosphoryl chloride, inroganic phosphorous compounds: phosphorous sesquisulfide N/A N/A EPA 1990 Health issue assessment rabbits, fish EPA/600/8-89/072 sodium ammonium Enlargement of parathyroid glands phosphate N/A 13011-54-6 Fazekas, IG 1954 by simple acidic compounds rabbits J. Anim. Sci. 80:1690-1695 Toxicity of combinations of certain No IP substances inorganic compounds to Daphnia investigated N/A N/A Freeman L and Fowler I 1953 magna stratus. Daphnia Sewage and Industrial wastes. 25(10): 1191-1195 Fire-Trol GTS-R, Fire-Trol LCG-R, Phos-ChekD75-F, Gaikowski MP, Hamilton Acute toxicty of Firefighting Chemical Phos-Chek WD-881 and Sj, Buhl KJ, McDonald SF Formulations to Four Life Stages of Ecotoxicology and Environmental safety. 34: Silv-Ex. N/A N/A and Summers CH 1996 Fathead Minnow. Fish 252-263 Acute Toxicity of Three Fire- Fire-Trol GTS-R, Fire-Trol Retardant and Two Fire-Suppressant LCG-R, Phos-ChekD75-F, Gaikowski MP, Hamilton Foam Formulations to the Early Life Phos-Chek WD-881 and Sj, Buhl KJ, McDonald SF Stages of Rainbow Trout Environmental Toxicology and Chemistry, Silv-Ex. N/A N/A and Summers CH 1996 (Oncorhynchus mykiss) Fish 15(8): 1365-1374 Site-specific acute and chronic No IP substances Gersich FR and Hopkins toxicity of ammonia to Daphnia Environmental Toxicology and Chemistry, 5(5): investigated N/A N/A DL 1986 magna straus Daphnia 443-447 ammonium pyrophosphate Gilliam J.W. And Sample Hydrolysis of pyrophosphates in ? (NH4)2 HP2O7 . H2O N/A N/A E.C. 1968 soils: pH and biological effects soils soil science 106(5): 352-357 Progress of Medical Science. Gold MD(Ed.) Hoppe JO, Therapeutics: A review of the toxicity Iron compounds N/A N/A Marcelli GMA, Tainter ML 1955 of iron compounds. various Am J Med Sci. 230(5): 558-571 Use of scintillometric quantitation of unscheduled DNA synthesis in No IP substances isolated rat hepatocytes for the investigated N/A N/A Hsia MTS 1987 screening of genotoxic agents. rat hepatocytes Cell biology and Toxicology. 3(2): 127-

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

cyclophosphates N/A N/A Kalliney SY 1972 Cyclophosphates n/a Topics in Phosphorous Chemistry, 7: 255-309

various N/A N/A Kanazawa T 1989 Inorganic phosphate mat erials N/A Materials science monographs. 52 (Book) Unidentified inorganic microorganism phosphate N/A N/A Kanematsu N and Kada T 1978 Mutagenicity of metal compounds. s Unknown source. 215-216 Kempf CA, Greenwood DA Studies relating to the toxicity of mice, rats, no IP substances N/A N/A & Nelson VE 1937 fluorine compounds dogs J. Lab. Clin. Med. 22:1133-1137 Riegel's handbook of industrial chemistry. 9th Various N/A N/A Kent JA (Ed) 1992 N/A Ed triammomium reactions of ammonium ortho- and pyrophosphate polyphosphate fertilizer in soil: I monohydrate TPP N/A N/A Khasawneh F.E. Et al 1974 Mobility of Phosphorus soils soil sci soc amer proc 38: 446-451 triammomium reactions of ammonium ortho- and pyrophosphate polyphosphate fertilizer in soil: II monohydrate TPP N/A N/A Khasawneh F.E. Et al 1979 Hydrolysis and reactions with soil soil soil sci soc amer proc 43: 52-58 Acute toxicity of agricultural fertilizers Single Super Phosphate N/A N/A Konar SK and Sarkar SK 1982 to fishes. Fish Geobios, 10: 6-9 Landi E, Logroscino G, Biomimetic Mg-substituted Proietti L, Tampieri A, hydroxyapatite: from synthesis to in Mg-substituted HAP N/A N/A Sandri M and Sprio S 2008 vivo behaviour. N/A J MaterSci: Mater Med. 19:239-247

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Effects of Fire Retardant Chemicals and Fire Suppressant Foam on North Proceedings of the North Dakotak Academy of Phos-Chek G75-F N/A N/A Larson Dl and Newton WE 1996 DakotaEnvironmental Prairie Vegetation.Persistence and Plants Science, 50: 137-144 Toxicity of Fire-Retardant Chemicals, Fire-Trol GTS-R and Phos- Fire-Trol GTS-R and Phos-Chek D75- Check D75-R N/A N/A Little EE and Calfee RD R to Fathead Minnows Fish Zooplankton Responses to Acidification: A Review of Laboratory UNKNOWN N/A N/A Locke A 1990 Bioassays Zooplankton Water, Air and Soil Pollution, 60 :135-148 In vitro cytogenic testins using sister chromatid exchange and Chinese chromosome aberration endpoints in hamster (CHO Abstracts of the eighteenth annual meeting of Chlorinated trisodium phosphateN/A N/A Loveday KS et al 1986 CHO cells. cells)? the evironmental mutagen society.

In vitro cytogenic testins using sister chromatid exchange and Chinese chromosome aberration endpoints in hamster (CHO Abstracts of the eighteenth annual meeting of Chlorinated trisodium phosphateN/A N/A Loveday KS et al 1987 CHO cells. cells)? the evironmental mutagen society.

Chromosome Aberration and Sister Chromatid Exchange Tests in Chinese Chinese Hamster Ovary Cells In hamster CHO Environmental and Molecular Mutagenesis, 13: Chlorinated trisodium phosphateN/A N/A Loveday KS et al 1989 Vitro: II. Results With 20 Chemicals cells 60-94 Clinical principles of environmental health : Not an IP paper N/A N/A Lowe J and Sullivan JB Jr 1992 Hazardous materials toxicology N/A 1053-62

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Lethat effects of 1888 chemicals Ammmonium upon four species of fish from Forest, wildlife and range experiment station. flurophosphate N/A N/A MacPhee C and Ruelle R 1969 Western North America Fish Bulletin No. 3 Study of the mutagenicity of metal Inorganic phosphates not derivatives with Salmonella investigated N/A N/A Marzin DR and Phi HV 1985 typhimurium TA102. Bacteria Mutation Research. 155: 49-51 Acute and chronic toxicity of No IP substances ammonia to freshwater fish: a site Environmental toxicology and chemistry, 5(5): investigated N/A N/A Mayes MA 1985 specific study fish 437-442 Fire-Trol GTS-R, Fire-Trol Acute Toxicity of Fire Control LCG-R, Phos-ChekD75-F, McDonald SF, Hamilton chemicals to Daphnia magna Phos-Chek WD-881 and SJ, Buhl KJ and Heisinger (Straus) and Selenastrum Ecotoxicology and environmental safety, 33: Silv-Ex. N/A N/A JF. 1996 capricornutum (Printz) Daphnia, algae 62-72 Fire-Trol GTS-R, Fire-Trol LCG-R, Phos-ChekD75-F, McDonald SF, Hamilton Acute Toxicty of Fire-Retardant and Phos-Chek WD-881 and SJ, Buhl KJ and Heisinger Foam-Suppressant Chemicals to Environmental Toxicology and Chemistry, Silv-Ex. N/A N/A JF. 1997 Hyalella Azteca (Suassure) Amiphod 16(7): 1370-1376 UNKNOWN N/A N/A Menzel 1932 Sieg alkaliphosphates N/A Ztsc hr. Elektrochem. 58(5): 283-299

Polyphosphate and Reactions and availability of banded superphosphate (fertilisers) N/A N/A Miner G and Kamprath E 1971 polyphosphate in field studies N/A Soil sci Soc Am J. 35: 927-930

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Morris R, Taylor EW, Cambridge University Press. ISBN: 978-0-521- N/A N/A N/A Brown DJA and Brown JA 1987 Acid Toxicity and Aquatic Animals. 33435-8

Mutagenic effects of some metal Inorganic phosphates not compounds on cultured mammalian investigated N/A N/A Nishimura M and Umeda M 1978 cells. Unknown source A Report of Research on the Behaviour and Impact of Chemical Phos-Chek XA N/A N/A Norris LA et al 1978 Fire Retardents in Forest Streams N/A N/A

Conditions for detecting the Sodium ammonium mutagenicity of divalent metals in Environmental and Molecular mutagenesis. 19: phosphate N/A N/A Pagano DA and Zeiger E 1992 Salomnella typhimurium. bacteria 139-146

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Inorganic phosphates not Chromosome damage in human cell investigated N/A N/A Paton GR and Allison AC 1972 cultures induced my metal salts. Mutation research. 16(3): 332-336

The effect of 0.025 and 0.0125 dietary sodium fluoride on the rat N/A: sodium fluoride N/A N/A Pindborg J 1957 kidney Rat Odont Rev. 8: 331-334 Abstr Pap Am Chem Soc 188th American Relative safety of common fertilizer Chemical Society Meeting Piladelphia Aug 26- phosphate carriers N/A N/A Plate H and Mathews D 1984 materials for planter application N/A 31 1984

The systems zinc oxides - phosphoric oxide - water and manganous oxide- phosphoric oxide-water at zinc phosphates' N/A N/A Salmon JE and Terrey H 1950 temperatures between 25° and 100° n/a J Chem Soc. Unknown vol: 2913-2924 Toxicity Evaluation of Superphosphate on Some Aquatic zooplankton, Invertebrates Exposed to worm, larvae superphosphate N/A N/A Sarkar SK 1989 Temperature. and molluscs J Environ Biol, 11(2): 97-100 sodium hexametaphosphate : Initial submission: rabbit eye irritant ESCOFOS (not applicable classification study with sodium to SHMP - substance is a Saylor JF and Kamienski hexametaphosphate with cover letter Stauffer Western RC NTIS OTS0545336 (T- formulation) N/A N/A FX 1971 dated 082892 Rat 1729)

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested sodium hexametaphosphate : Initial submission: rabbit eye irritant ESCOFOS (not applicable classification study with sodium to SHMP - substance is a Saylor JF and Kamienski hexametaphosphate with cover letter Stauffer Western RC NTIS OTS0545336 (T- formulation) N/A N/A FX 1971 dated 082892 Rabbit 1729) sodium hexametaphosphate : Initial submission: rabbit eye irritant ESCOFOS (not applicable classification study with sodium to SHMP - substance is a Saylor JF and Kamienski hexametaphosphate with cover letter Stauffer Western RC NTIS OTS0545336 (T- formulation) N/A N/A FX 1971 dated 082892 Rabbit 1729) No IP substances investigated N/A N/A Schardein JL 1993 Chemically induced birth defects. N/A 2nd edition. 842-869 Effects of Fire Retardant Application on Heathland Surface-Dwelling Ant Species (Order: Hymenoptera; Family Formicidae) in Victoria Fire Retardants N/A N/A Seymour B, Collet NG 2009 Australia Invertebrates Forest Ecology Management, 257: 1261-1270 No inorganic phosphates Archives of Environmental Contamination and investigated. N/A N/A Shafer EW and Bowles WA 1985 Acute oral toxicity and repellency of 933Mice chemicals to HouseToxicology. and Deer 14:111-129 mice

Shpunt SY, Belopolskii AP unknown N/A N/A & Shulgina MN 1951 unknown n/a Zh Prikl Chim. 24: 404-4 12

Aluminium N/A N/A Sjogren B and Elinder CG 1993 Alumini um N/A Nordic expert group. Arbete och Halse. 1:55-84

The effects of the absorption of fluoride. V. The chemical determination of flouride in human Smith FA , Gardner DE, soft tissues following prolonged No IP substances reported N/A N/A Leone NC and Hodge HC 1960 ingestion of fluoride at various levels Human AMA Arch. Indust. Health. 21: 330-332 Effect of calcium and phosphorus on N/A N/A N/A Spencer H 1975 fluoride metabolism in man. human J. Nutr. 105(6): 733-740. Effect of phosphorus on the absorption of calcium and on the Sodium glycerophosphate N/A N/A Spencer H 1978 Calcium balance in Man. human J. Nutr. 108:447-457

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Tissue changes in rats lungs caused Phosphate berlinite by hydroxides, oxides and (AIPO4) N/A N/A Stacy 1958 phosphates of aluminium and iron rat J Path Bact 77: 417-426 A retrospective cohort mortality study of a phosphate fertilizer production Phosphate ore N/A N/A Stayner LM et al 1985 facility Human Arch Environ Health, 40: 133-138 Not applicable - review of Presented at the Pitman-Moore Nutrition for assays to determine Sullivan TW and Douglas Phosphorious bioassays - the Nineties Conference, Bloomington, MN, available phosphorous N/A N/A JH 1990 Developments in five decades N/A September 17, 1990. 18-

DCP (not chemical – precipitated from bone) Biological value of bone-precipitated compared to commercially dicalcium phosphate in turkey starter available forms. N/A N/A Sullivan TW et al 1994 diets. turkey Poultry Science. 73: 122-128 The dissociation of calcium Calcium aluminium aluminium phosphate, phosphate N/A N/A Taylor AW and Gurney EL 1964 CaAlH(PO4)2.6H20. N/A Soil Sci. Soc. Am J. 28:63-65 Hydrolysis of condensed phosphates condensed phosphates N/A N/A Thilo E 1955 in aqueous solution water and soil Angewandte Chemie, 67:141-185 Radiolabelled phosphate N/A N/A Tomatis 1973 Transplacental Carcinogenesis N/A WHO condensed phosphates N/A N/A Topley B 1949 Physical properties n/a Q Rev Chem Soc. 3:345-370 On the functional relationship between the pituitary gland and the Serum phosphorous N/A N/A Tornblom N 1949 parathyroids Acta Endocrinol Suppl, 4: 1-76

Ferrous and Ferric A Comparison of Ferrous and Ferric ammonium sulphate N/A N/A Underwood EJ 1938 Iron in the Nutrition of the Rat. Rat Journal of Nutrition, 16(3): 299-308 UNKNOWN N/A N/A Van Wazer JR 1954 ? N/A J Phys Chem. 58: 739 orthophosphate, pyro- and Van Wazer JR, Griffith EJ Analysis pH titration of soluble tripolyphosphate mixtures N/A N/A and McCullough JF 1954 phosphates and their mixtures Anal. Chem. 26: 1755 – 1760 The effect of the solution Ca / P ratio Verbeeck RMH and on the kinetics of dissolution of Octocalcium phosphate N/A N/A Devenyns JAH 1990 octocalcium phosphate. Journal of Crystal Growth. 102: 647-657

Acute toxicity and skin corrosion data No IP substances for some organic and inorganic Toxicology and Applied Pharmacology. investigated N/A N/A Vernot EH et al 1977 compounds and aqueous solutions. Rabbit, rat 42:417-423

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

The mechanism of the hydrolysis of sodium cyclo-triphosphate, polyphosphates. VI. The effect of sodium cyclo- cations on the hydrolysis of cyclo-tri- Bulletin of the Chemical Society of Japan. trimetaphosphate n/a n/a Watanabe M 1982 and cyclo-tetraphosphates N/A 55(12): 3766-3769

Watanabe W, Suzumori H, The synthesis and decomposition of Bulletin of the Chemical Society of Japan. 35: calcium tetraphosphate N/A N/A Maeda M and YamadaT 1980 calcium tetraphosphate N/A 2663-2665 sodium and potassium The alkali orthophosphates. Phase phosphates N/A N/A Wendrow B & Kobe KA 1954 equilibria in aqueous solution. n/a Chem Rev. 54: 891-924 UNKNOWN N/A N/A Wenger P 1911 Tables N/A Annuelles. 2: 411 -413

Chemonics Fire Foam 103 Monsanto Phos-Chek WD 861, 881 Wormal SILV-EX Prepared by Norecol Environmental Angus Forexpan Consultants Ltd on behalf of Manager, Fire 3m FB 100 Toxicological Review of Fire Fighting Management Forest Protection Branch British N/A N/A Wheeler IP 1989 Foams. N/A Columbia. Ferric Iron Absorption in Rats: Relationship to Iron Status, Endogenous Sulfhydryl and Other Wien EM and Van Campen Redox Components in the Intestinal ferric chloride N/A N/A DR 1991 Lumen Rat Journal of Nutrition 121(6): 825-831 Salmonella Mutagenicity tests: IV. chlorinated trisodium Results from the testing of 300 Environmental and Molecular Mutagenesis. 11 phosphate N/A N/A Zeiger E et al 1988 Chemicals Salmonella (suppl 12) 1-158 Kinetics and mechanisms of octacalcium phosphate N/A N/A Zhang J 1992 octocalcium phosphate at 37°C. J. Phys. Chem. 96: 5478-5483 Inorganic polyphosphate: toward making a forgotten polymer polyphosphate' n/a n/a Kornberg A 1995 unforgettable n/a J. Bacteriol. 1n(3):491-496. various n/a n/a Deshpande SS 2002 Handbook of Food Toxi cology various n/a Bone and Soft Tissue Changes with The Journal of Clinical Investigation. 51: 2834- unknown n/a n/a Laflamme GH & Jowsey J 1972 Oral Phosphate Supplements dogs 2840 J. L. Montgomery, J. R. Blanton, Jr., R. L. Horst, M. L. Galyean, K. J. Morrow, Effects of biological type of beef Jr., D. B. Wester and M. F. steers on vitamin D, calcium, and phosphorus' n/a n/a Miller 2004 phosphorus status cows J Anim Sci 2004. 82:2043-2049.

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested various n/a n/a NRC 2005 NRC Mineral tolerance of animal s various n.a The effect of calcium source and no IP substance tested n/a n/a Charles OW 1975 level on egg shell quality hens Poultry Science. 54: 1744

joyce Jr, Pierce KR, clincial study of nutritional secondary Journal of the American vetinary medical no IP substance tested n/a n/a Romane WM and Baker JM 1971 hyperparathyroidism in horses. horse association. 151(12): 2033-2043 Die antimikrobielle Wirkung von Polyphosphaten. Ph.D. thesis. Technical University of Munieh. various polyphosphates n/a n/a Maier, S. K. 1999 Freising, Germany. n/a TOC( SUPPL: *) Effect of polyphosphates оп lactic Radkowski, М. and Kafel, acid bacteria of processing unknown n/a n/a S. 1985 importance unknown Med Weter 400:328-329 Effect of High Levels of Inorganlc inorganic phosphate - Phosphate on Aquatic Organisms ln Gov. Rep. Announce. Index (U.S) NTIS various substance id n/a n/a Strange, J. R. 1977 Phosphate-Rlch Environments unknown PB263290. 77(9):181 Secondary Metabolism: Control by Temperature and inorganic Developments in Industrial Microbiology. various n/a n/a Weinberg ED 1974 phosphate n/a Handbook. Chap 8 CRCF phosphates as food various n/a n/a Ellinger RH 1972 ingredients n/a Handbook EFSA: Scientific opinion on the safety of ferrous ammonium phosphate as a source of iron added for nutritional purposes to foods for the general population (including ferrous ammonium food suplements) and to foods for phosphate N/A 10101-60-7 EFSA particular nutritional uses. VARIOUS The EFSA Journal 2010; 8(5):1584

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Sodium fluoride-induced chromosome aberrations in different stages of the cell cycle: a proposed Aardema MJ, Gibson DP & mechanism Mutation Research, 223 (1989) 191-203 sodium fluoride n/a n/a LeBoeuf A 1989 Cells Results and conclusions of the Bucher JR, Hejtmancik MR, national toxicology program's rodent Toft JD, Persing RL, Eustis carcinogenicity studies with sodium Int. J. Cancer: 48, 733-737 sodium fluoride n/a n/a SL & Haseman JK 1991 fluoride rats, mice Dunipace AJ, Zhang W, Genotoxicity of fluoride in mouse Noblitt TW, Li Y & Stokey sperm morphology and micronucleus sodium fluoride n/a n/a GK 1989 studies mouse Journal of Dental Research. 68:334 Relationship between fluoride in the drinking water and the plasma fluoride - unknown source n/a n/a Ekstrand J 1978 fluoride concentration in man. human Caries Research. 12: 123-127

sodium fluoride and chromosome damage (in vitro human lymphocyte sodium fluoride n/a n/a Albanese R 1987 and in vivo micronucleus assays) n/a mutagenesis. 2(6): 497-499 Evaluation of Eppawala rock phosphate as a phosphorus Ganegoda GAP & supplement in diets for growing Chicken and rock phosphate N/A N/A Gunaratne SP 1986 chickens and pigs pigs J. Natn. Sci. Coun. Sri Lanka. 14(2):251-260 Genotoxic effects of fluoride Li Y, Heerema NA, evaluated by sister-chromatid sodium fluoride n/a n/a Dunipace AJ & Stookey GK 1987 exchange cells Mutation Research. 192: 191-201 clastogenic activity of sodium fluoride to rat vertebrael body-derived celss in sodium fluoride N/a n/a Mihashi M, Tsutsui T 1996 culture cells Mutation Research. 368: 7-13

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested various forms of Giavaresi G, Fini M, Gnudi Comparison of calcitonin, monofluorophosphate - not S, Nicoli Aldini N, Rocca M, alendronate and fluorophosphate SFP n/a n/a Carpi A & Giardino R 2001 effects on ovariectomised rat bone rat Biomed and Pharmacother. 55:397-403 Cell cycle dependenceof cytotoxicity and clastogenicity induced by treatment of synchronized human diploid fibroblasts with sodium sodium fluoride - NaF n/a n/a Hayashi N & Tsutsiu T 1993 fluoride cells Mutation Research. 290:290-302 Genetic toxicity of biomaterial. 2. DNA damaging effects of sodium fluoride and other fluoride sodium fluoride - NaF n/a n/a Kanematsu N 1985 compounds bacteria Jpn. J. Oral Biol. 27: 372-374 The Genotoxic and Cytotoxic Activities of Inorganic Fluoride in Cultured Rat Bone cells - rat bone Archives of Environmental Contamination and sodium fluoride - NaF n/a n/a Khali AM & Da'dara AA 1994 Marrow Cells marrow Toxicology. 26:60-63 sodium fluoride - NaF n/a n/a Kishi K & Tonomura A Cytogenic effects of sodium fluoride cells unknown Absence of mutagenic and Li Y, Dunipace A & Stookey antimutagenic activities of fluoride in sodium fluoride - NaF n/a n/a GK 1987 Ames Salmonella assays bacteria Mutation Research, 190: 229-236 Lack of genotoxic effects of fluoride Li Y, Dunipace A & Stookey in the mouse bone-marrow sodium fluoride - NaF n/a n/a GK 1987 micronucleus test cells - mouse J Dent Res. 66: 1687-1690 Li J, Suzuki Y, Hayashi K & The genotoxic effect of sodium sodium fluoride - NaF n/a n/a Shimizu H 1991 fluoride cells/bacteria Unknown Genotoxic evaluation of chronic fluoride exposure: sister-chromatid Li Y, Zhang W, Noblitt TW, exchange sodium fluoride - NaF n/a n/a Dunipace AJ & Stookey GK 1989 study hamsters Mutation Research, 227 :159-165 National Toxicology Program. US Department of Heatlh and Human Toxicology and carcinogenesis Services. Public Health studies of sodium fluoride (CAS No. Service. National Institute 7861-49-4) in F344/N rats and sodium fluoride - NaF n/a n/a of Health. 1990 B6c3F1 mice (drinking water studies) rats, mice NTP TR-393

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Collins T.F.X, Sprando R.L, Black T.N, Shackelford M.E, Bryant M.A, Olejinik N, Ames M.J, Rorie J.I & Multigenerational evaluation of sodium fluoride - NaF n/a n/a Ruggles D.I 2001 sodium fluoride in rats rats Food and Chemical Toxicology 39, 601-613 Sprando RL, Collins TFX, Testing the potential of sodium Black TN, Rorie J, Ames fluoride to affect spermatogenesis in sodium fluoride - NaF n/a n/a MJ & O'Donnell M 1997 the rat RATS Food and Chemical Toxicology. 35:881-890

Collins T.F.X, Sprando R.L, Black T.N, Shackelford M.E, Bryant M.A, Olejinik Developmental toxicity of sodium N, Ames M.J, Rorie J.I & fluoride measured during multiple sodium fluoride - NaF n/a n/a Ruggles D.I 2001 generations RAT Food and Chemical Toxicology 39, 867-876 Developmental toxicity of sodium fluoride (CAS #7681-49-4) in sodium fluoride - NaF n/a n/a Heindel J 1994 Sprague-Dawley (CD) rats RAT NTIS PB95110193 Developmental toxicity of sodium fluoride (CAS #7681-49-4) in New sodium fluoride - NaF n/a n/a Heindel J 1993 Zealand White (NZW) rabbits rabbit NTIS PB94-142684 Collins, TFX, RL Sprando, ME Shackelford, TN Black, MJ Ames, JJ Welsh, MF Balmer, N. Olejnik & DI Developmental toxicity of sodium sodium fluoride - NaF n/a n/a Ruggles 1995 fluoride in rats rats Food & Chemical Toxicity. 33(1): 951-960 physiologie et pharmacocinetique du SFP-calcium carbonate monofluorophosphate disodique- complex n/a n/a Rouveix B, Faurisson F 1988 carbonate de calcium human Lettre du Pharmacologue. 2: 1-4 Spak CJ, Ekstrand J & Bioavailability of Fluoride Added to sodium fluoride - NaF n/a n/a Zyberstein D 1982 Baby Formula and Milk human Caries Res. 16: 249-256 Cytotoxicity, chromosome aberrations and unscheduled DNA synthesis cultured human diploid Tsutsui T, Suzuki N, fibroblasts induced by sodium sodium fluoride - NaF n/a n/a Ohmori M & Maizumi H 1984 fluoride cells Mutation Research, 139 193-198 Induction of unscheduled DNA Tsutsui T, Ide K & Maizumi synthesis in cultured human oral sodium fluoride - NaF n/a n/a H 1984 keratinocytes by sodium fluoride cells Mutation Research, 140: 43-48

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Tsutsui T, Tanaka Y, No increases in chromosome Matsudo Y, Uehama A, aberrations in human diploid Someya T, Hamaguchi F, fibroblasts following exposure to low Yamamoto H & Takahashi concentrations of sodium fluoride for sodium fluoride - NaF n/a n/a M 1995 long times cells Mutation Research 335: 15-20 Sodium Fluoride-induced Morphological and Neaplastic Transformation, Chromosome Aberrations, Sister Chromatid Exchanges, and Unscheduled DNA Tsutsui T, Suzuki N & Synthesis in Cultured Syrian Hamster sodium fluoride - NaF n/a n/a Ohmori M 1984 Embryo Cells cells CANCER RESEARCH 44. 938-941. Voroshilin SI, Plotko EG, Cytogenetic effect of inorganic hydrogen fluoride only Gatiyatullina EZ & Gileva fluorine compunds on human and cells: tested n/a n/a EA 1973 animal cells in vivo and in vitro human/animal Sov Genet. 9:492-496 calcium phosphate The phosphate of calcium. Part V. unspecified n/a n/a Bassett H 1958 Revision of the earlier space diagram n/a Journal of the Chemistry. 2949-2955

Maurer JK, Cheng MC, Two-year carcinogenicity study of Journal of the National Cancer Institute. sodium fluoride n/a n/a Boysen BG & Anderson RL 1990 sodium fluoride in rats rat 82(13): 1118-1126 phosphate' n/a n/a Nordin EC 1989 Phosphorus n/a Journal of Food and Nutrition. 45:3. 61-75 Shyu LJ, Perez L, Zawacki The solubility of octacalcium SJ, Heughebaert JC & phosphate at 37 °C in the system octacalcium phosphate n/a n/a Nancollas GH 1983 Ca(OH)2-H3PO4-KNO3-H2O n/a Journal of Dental Research . 62: 398-400 Takeda E, Taketani Y, inorganic phosphate - Sawada N, Sato T & The regulation and function of various substance id n/a n/a Yamamoto H 2004 phosphate in the human body n/a Biofactors 21. 345-355

Effect of phosphate supplementation on the expression of the mutant Tenenhouse HS, Martel J, phenotype in murine x-linked phosphate' n/a n/a Rubin J & Harvey N 1994 hypophosphatemic rickets. mice Bone. 15(6): 677-683 Biavailability and pharmacokinetics glutamine of fluoride from two glutamine monofluorophosphate n/a n/a Warneke G, Setnikar I 1993 monofluorophosphate preparations human ArzneimForschDrugRes. 43(I).5:584-588

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested sodium tetraborate and Soucek D, Dickenson A Acute and chronic toxicity of boron to Environmental Toxicology and Chemistry, Vol. boric acid n/a n/a and Koch BT 2011 a variety of fresh water organisms various 30, No. 8, pp. 1906–1914, Tatyana V. Kulakovskaya, Inorganic polyphosphate in industry, various inorganic Vladimir M. Vagabov, Igor agriculture and medicine: modern polypjosphates n/a n/a S. Kulaev 2010 state and outlook n/a Process biochemistry Purification and Characterization of Highly Active and Stable Polyphosphatase from Saccharomyces cerevisiae Cell yeast polyphosphates n/a n/a Andreeva NA & Okorokov 1993 Envelope (S.cerevisiae) YEAST VOL. 9: 127-1 39 Inorganic polymeric Muller WEG, Wang X, phosphate/polyphosphate as an Diehl-Seifert B, Kropf K, inducer of alkaline phosphatase and Schlossmacher U, a modulator of intracellular Ca2+ Inorganic polymeric Lieberwirth I, Glasser G, level in osteoblasts (SaOS-2 cells) in phosphate/polyphosphate n/a n/a Weins M & Schroder HC 2011 vitro Acta Biomaterialia 7 (2011) 2661–2671

Y. Hacchou, T. Uematsu, O. Ueda, Y. Usui, S. Uematsu, M. Takahashi, T. Uchihashi, Y. Kawazoe, T. Shiba, S. Kurihara, M. Inorganic Polyphosphate: a Possible inorganic polyphosphate n/a n/a Yamaoka and K. Furusawa 2007 Stimulant of Bone Formation n/a J DENT RES 2007 86: 893 Mammalian intestinal alkaline phosphatase acts as highly active Biochimica et Biophysica Acta 1547 (2001) inorganic polyphosphates n/a n/a Lorenz B & Schroder HC 2001 exopolyphosphatase n/a 254-261 Lubov Ryazanova, Nadeschda Andreeva, Tatiana Kulakovskaya, The early stage of polyphosphate Airat Valiakhmetov, Valerii accumulation in Saccharomyces Yashin, Vladimir Vagabov, cerevisiae: comparative study by yeast Advances in Bioscience and Biotechnology, inorganic polyphosphate n/a n/a Igor Kulaev 2011 extraction and DAPI staining (S.cerevisiae) 2011, 2, 293-297 Y. Kawazoe, T. Shiba, R. Nakamura, A. Mizuno, K. Tsutsumi, T. Uematsu, M. Yamaoka, M. Shindoh and Induction of Calcification in MC3T3- inorganic polyphosphate n/a n/a T. Kohgo 2004 E1 Cells by Inorganic Polyphosphate n/a J DENT RES 2004 83: 613

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Catalytic ability of alkaline phosphatase to promote P-O-P bond inorganic diphosphate, Yoza N, Onoue S & hydrolyses of inorganic diphosphate Chemical society of Japan. Chemistry letters. triphosphate n/a n/a Kuwahara Y 1997 and triphosphate n/a 491-492 Kaneko H, Shimada A & Short-term algal toxicity test based phosphate n/a n/a Hirayama K on phosphate uptake algae Water Research 38 (2004) 2173–2177 Yu Y, Wang J, Liu C, Evaluation of inherent toxicology and Zhang B, Chen H, Guo H, biocompatibility of magnesium Magnesium phosphate Zhong G, Qu W, Jiang S & phosphate Colloids and Surfaces B: Biointerfaces 76 : cement n/a n/a Huang H 2010 bone cement n/a 496–504 Assessment of Metal Availability in Condor JM, Lanno RP & Smelter Soil Using Earthworms and rock phosphate n/a n/a Basta NT 2001 Chemical Extractions earthworm J. Environ. Qual. 30:1231–1237 A potential link between phosphate inorganic phosphate - and aging—Lessons from Klotho- Mechanisms of Ageing and Development 131 : various substance id n/a n/a Kuro-o M 2010 deficient mice mice 270–275 Bioassay and use in irrigation of Gouider M, Feki M & untreated and treated wastewaters Ecotoxicology and Environmental Safety Triple Super Phosphate n/a n/a Sayadi S 2010 from phosphate fertilizer industry plants 73:932–938

Genetic induction of phosphate toxicity significantly reduces the Biochemical and Biophysical Research Ohnishi M, Kato S & survival Communications xxx (2011) xxx–xxx Article in phosphate n/a n/a Razzaque MS 2011 of hypercholesterolemic obese mice mice press. Contributions on crystal structures and thermal behaviour of anhydrous No IP substances: El-Bali B, Boukhari A, phosphates XXIX - Preparation and SrMn2(PO4)2 and Β'- Glaum R, Gerk M and structure determination of Zeitschrift für anorganische und allgemeine Mn3(PO4)2 N/A N/A Maaß K 2000 SrMn2(PO4)2 and Β'-Mn3(PO4)2 N/A Chemie, 626(12): 2557-2562

Adequacy and consistency of animal studies to evaluate the neurotoxicity No IP substances: Mn Gwiazda R, Lucchini R and of chronic low-level manganese Rodent, Journal of Toxicology and Environmental (unspecified) N/A N/A Smith D 2007 exposure in humans primate Health, Part A, 70(7) Huminicki DMC and The Crystal Chemistry of the Reviews in Mineralogy and Geochemistry, 48: Various phosphates N/A N/A Hawthorne FC 2002 Phosphate Minerals N/A 123-253

No IP substances Eaton LJ, Hoyle J and King Effects of deicing salt on lowbush Canadian Journal of Plant Science, 79: 125- investigated - NaCl N/A N/A A 1999 blueberry flowering and yield N/A 128

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Acute and chronic effects of sodium No IP substances and potassium on the tropical investigated - NaCl and freshwater cladoceran Pseudosida KCl N/A N/A Freitas EC and Rocha O 2011 ramosa Crustacean Ecotoxicology, 20: 88-96 No IP substances El-Deeb Ghazy MM, Effects of on survival, growth investigated - NaCl and Habashy MM, Kossa FI and and reproduction of the water flea, sea water N/A N/A Mohammady EY 2009 Daphnia magna Crustacean Nature and Science, 7(11): 28-42

Chronic effect of NaCl salinity on a freshwater strain of Daphnia magna No IP substances Martínez-Jerónimo F and Straus (Crustacea: Cladocera): A Ecotoxicology and Environmental Safety, 67: investigated - NaCl N/A N/A Martínez-Jerónimo L 2007 demographic study Crustacean 411-416

No IP substances Nielsen DL, Brock MA, Effects of increasing salinity on investigated - NaCl N/A N/A Rees GN and Baldwin DS 2003 freshwater ecosystems in Australia N/A Australian Journal of Botany, 51: 655-665 Acute and chronic toxicity of No IP substances (KCl) and investigated - KCl and potassium acetate (KC2H3O2) to potassium acetate Daphnia similis and Ceriodaphnia (KC2H3O2) N/A N/A Utz LRP and Bohrer MBC 2001 dubia (Crustacea; Cladocera) Crustacea Bull Environ Contam Toxicol, 66: 379-385

No IP substances The sensitivity of two cladocerans to investigated - NaCl and water quality variables: salinity and CaCO3 N/A N/A Cowgill UM and Milazzo DP 1990 hardness Crustacea Arch Hydrobiol, 120(2): 185-196 Determining ecoregional reference conditons for nutrients, secchi depth Dodds WK, Carney E and and chlorophyll a in Kansas lakes Phosphorus (unspecified) N/A N/A Angelo RT 2006 and reservoirs Crouzet P, Nixon S, Rees Phosphate (unspecified), Y, Parr W, Laffon L, orthophosphate, Bøgestrand J, Kristensen polyphosphate, P, Lallana C, Izzo G, Bokn phosphorus (unspecified), T, Bak J, Lack TJ and P2O5 N/A N/A Thyssen N (Ed) 1999 Nutrients in European ecosystems

Phosphorus (unspecified), European Environment orthophosphate N/A N/A Agency ? Nitrogen and phosphorus in rivers Indicator fact sheet (WEU02)

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

The global phosphorus cycle: past Phosphorus (unspecified) N/A N/A Filippelli GM 2008 present and future Elements, 4:89-95

Calcium, magnesium, sodium, potassium, ammonium, sulfate, nitrate, chloride, orthophosphate, hydrogen, bicarbonate, National Atmospheric Quality assurance report NADP/NTN hydroxide N/A N/A Deposition Program 1991 deposition monitoring

Various (Ca2+, Mg2+, Na+, Treatise on Geochemistry : Surface and K+, Cl-, SO42-, HCO3-, Global occurrence of major elements Ground Water, Weathering, and Soils, Elsevier SiO2) N/A N/A Meybeck M 2003 in rivers Ltd, ISBN: 0-08-044340-0 pages 207–223 Palaeogeography, Palaeoclimatology, The quality of rivers: from pristine Palaeoecology (Global and Planetary Change Various (S, Na, K, N, P) N/A N/A Meybeck M and Helmer R 1989 stage to global pollution Section), 75: 283-309 Reference conditions of European Phosphorus N/A N/A Solheim AL (Ed) 2005 Lakes REBECCA Project (draft paper) Hardness in drinking water; Originally published in Guidelines for drinking Background document for water quality, 2nd ed, Vol 2, Health criteria and No IP substances development of WHO guidelines for other supporting information, World Health investigated - CaC03 N/A N/A World Health Organisation 2003 drinking-water quality Organisation, Geneva, 1996 Phosphate is a specific signal for No IP substances Beck GR Jr, Zerler B and induction of osteopontin gene investigated N/A N/A Moran E 2000 expression PNAS, 97(15): 8352-8357 Camalier CE, Young MR, Bobe G, Perella CM, Elevated phosphate activates N-ras Colburn NH and Beck GR and promotes cell transformation and Phosphate (unspecified) N/A N/A Jr 2010 skin tumorigenesis Cancer Prev, 3(3): 359-370 Low dietary inorganic phosphate Xu C-X , Jin H, Lim H-T, stimulates lung tumorigenesis Ha Y-C, Chae C-H, An G- through altering protein translation Phosphate (unspecified) N/A N/A H, Lee K-H and Cho M-H 2010 and cell cycle in K-rasLA1 mice Nutrition and Cancer, 62(4): 525-532 High dietary inorganic phosphate increases lung tumorigenesis and Phosphate (unspecified) N/A N/A Jin H et al 2009 alters Akt signaling Am J Respir Crit Care Med, 179: 59-68

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

A Medical Hypothesis: Phosphorus Phosphate (unspecified) N/A N/A Kapur S 2000 Balance and Prostate Cancer Cancer Investigation, 18(7): 664-669

Giovannucci E, Rimm EB, Wolk A, Ascherio A, Stampfer MJ, Colditz GA Calcium and fructose intake in Phosphate (unspecified) N/A N/A and Willett WC 1998 relation to risk of prostate cancer Cancer Research, 58: 442-447 PLoS Biology www.plosbiology.org , 5(7): 2007 1403-1405 and Biological Stoichiometry in and Stoichiometry and the New Biology: Human Cancer, PLoS ONE, www.plosone.org, Phosphate (unspecified) N/A N/A Elser J 2010 The Future Is Now 10: 1-7

Phosphate (unspecified) N/A N/A Borrell B 2010 Elemental shortage The Scientist, 24(11): 46 Biological stoichiometry: an Elser JJ, Nagy JD and ecological perspective on tumor Phosphate (unspecified) N/A N/A Kuang Y 2003 dynamics BioScience, 53(11): 1112-1120

Elser JJ, Kyle MM, Smith Biological stoichiometry in human PLoS ONE 2(10): e1028. Phosphorus N/A N/A MS and Nagy JD 2007 cancer doi:10.1371/journal.pone.0001028

Phosphate and the regulation of DNA Engström W and replication in normal and virus Phosphate (unspecified) N/A N/A Zetterberg A 1983 transformed 3T3 cells Biochem J, 214: 695-702 Statement of the International Food Additives Council and the European Chemical Industry Council on Jin et al "High Dietrary Inorganic Phosphate Increases Lung Tumorigenesis and Alters Akt http://www.slideshare.net/changezkn/summary- Phosphate (unspecified) N/A N/A Anon 2009 Signaling" 5553163 [accessed 29 March 2012]

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

The rate of changes of inorganic phosphate content of Ehrlich Ascites- Phosphate (unspecified) N/A N/A Laws JO and Strickland LH 1962 Tumour cells Biochem J, 83: 84-91 Opinion of the scientific panel on dietetic products, nutrition and allergies on a request from the No IP substances commission related to the tolerable investigated N/A N/A EFSA 2004 upper intake level of iron The EFSA Journal, 125, 1-34

Manganese dosimetry: species Aschner M, Erikson KM differences and implications for Manganese (unspecified) N/A N/A and Dorman DC 2005 neurotoxicity Critical Reviews in Toxicology, 35:1-32 Aluminium intoxication from aluminium-containing phosphate Andreoli SP, Bergstein JM, binders in children with azotemia not New England Journal of Medicine, 310(17): Aluminium hydroxide N/A N/A Sherrard DJ 1984 undergoing dialysis 1079-84

No IP substances Phalangeal metastases from investigated N/A N/A Vaezy A and Budson DC 1978 bronchogenic carcinoma JAMA, 239(3): 225-226

No IP substances Acid ingestion: toxicology and investigated N/A N/A Penner GE 1980 treatment Ann Emerg Med, 9(7): 374-379 The effect of feeding sodium fluoride Bethke RM, Kick CH, and rock phosphate on bone Edgington BH and Wilder development in swine: a preliminary Rock phosphate N/A N/A OH 1930 report J Anim Sci: 29-33

Ritz E, Hahn K, Ketteler M, Phosphate additives in food—a Deutsches Ärzteblatt International, 109(4):49- Phosphate (unspecified) N/A N/A Kuhlmann MK and Mann J 2012 health risk 55 Dairy cattle need phosphorus in Michigan Agricultural Experiment Station ration: lack of this element causes Quarterly Bulletin, 10(4): 152-156 [ISBN Raw rock phosphate N/A N/A Reed OE and Huffman CF 1928 depraved appetites of animals 00976911] Phosphate: the new cholesterol? The various inorganic role of the phosphate axis in non- various phosphates n/a n/a Ellam TJ, Chico TJA 2012 uremic vascular disease. investigations atherosclerosis, 220: 310-318 inorganic phosphate - The emerging role of phosphate in various substance id n/a n/a Giachelli CM 2009 vascular calcification n/a Kidney International (2009) 75, 890–897;

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

inorganic phosphate - Gonzalez-Parra E, Tunon Phosphate: a stealthier killer than various substance id n/a n/a J, Egido J & Ortiz A 2012 previously thought Cardiovascular pathology: Article in press Gutierrez OM, Anderson C, Isakova T, Scilla J, Negrea L, Anderson AH, Bellovich K, Chem J, Robinson N, Low Socioeconomic Status inorganic phosphate - Ojo A, Lash J, Feldman HI Associates with Higher Serum human - cohort various substance id n/a n/a & Wolf M 2010 Phosphate Irrespective of Race study J Am Soc Nephrol 21: 1953–1960 inorganic phosphate - Kendrick J, Kestenbaum B Phosphate and Cardiovascular Advances in Chronic Kidney Disease, Vol 18, various substance id n/a n/a and Chonchol M 2011 Disease human No 2 (March), 2011: pp 113-119 inorganic phosphate - Lau WL, Pai A, Loe SM & Direct Effects of Phosphate on Advances in Chronic Kidney Disease, Vol 18, various substance id n/a n/a Giachelli CM 2011 Vascular Cell Function human No 2 (March), 2011: pp 105-112 inorganic phosphate - Phosphate toxicity: new insights into human and various substance id n/a n/a Razzaque MS 2011 an old problem animals Clinical Science (2011) 120, 91–97 Interactive effects of phosphorus and Li M, Costello DM, Allen copper on Hyalella azteca via phosphorus' n/a n/a Costello G 2012 periphytonin aquatic ecosystems plankton Ecotoxicol.Environ.Saf. phosphorus as food supplement (source not Wise M.B., Wentworth, Availability of the phosphorus in detailed) n/a n/a R.A. & Smith, S.E. 1961 various sources for calves Cows Journal of Animal Science. 20: 329-335

Associations of socioeconomic status Guitierrez OM, Katz R, and prcessed food intake with serum Peralta CA, de Boer IH, phosphorus concentration in Siscovick D, Wolf M, Roux community-living adults: The multi- AD, Kestenbaum B, ethnic study of atherosclerosis Article in press - the National Kidney phosphorus from diet n/a n/a Nettleton JA & Ix JH 2012 (MESA) human Foundation

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Bell RR, Draper HH, Tzeng Physiological responses of human phosphorus from diet (form DYM, Shin HK & Schmidt adults to foods containing phosphate unspecified) n/a n/a GR 1977 additives man Journal of Nutrition. 107:42-50 inorganic phosphate - 1990- Principles of nutritional assessment. various substance id n/a n/a Gibson RS 2005 2nd edition. n/a Book (no ISBN details) inorganic phosphate - The tubular reabsorption of various substance id n/a n/a Bijvoet OLM & Morgan B 1970 phosphate in man man [From Hioco - source unknown] 153-179 Effects of dietary and hormonal factors on phosphate metabolism in dietary phosphorus' n/a n/a Clark I 1970 the rat rat [From Hioco - source unknown] 89-110 inorganic orthophosphate / Orthophosphate, pyrophosphate and pyrophosphate (form not diphosphonates in calcium specifed) n/a n/a Fleisch H & Russell RGG 1970 metabolism n/a [From Hioco - source unknown] 57 - 64

Goldsmith RS, Richards R, phosphate supplements' Dube WJ, Hulley SB, Metabolic effects and mechanism of (unspecifed) n/a n/a Holdsworth D & Ingbar SH 1970 action of phosphate supplements man [From Hioco - source unknown] 271-291 Phosphate et metabolisme phosphocalcique - regulation phosphate' normale et aspects (unspecified/various) n/a n/a Hioco DJ 1970 physiopathologiques [FRENCH] n/a Symposium summary (source unknown) phosphate' Parathyroid hormone, calcitonin and (unspecified/various) n/a n/a MacIntyre I 1970 phosphate homeostasis n/a [From Hioco - source unknown] 181-187 inorganic phosphate' The state of inorganic phosphate in (various- not specified) n/a n/a Marshall RW & Nordin BEC 1970 plasma and its relation to other ions n/a [From Hioco - source unknown] 127- 138 inorganic phosphate' Rasmussen H, Kurokawa K (various- not specified) n/a n/a & De Long A 1970 Phosphate and bone cell function n/a [From Hioco - source unknown] 7- 27 inorganic phosphate' Use of bone cultures in studying (various- not specified) n/a n/a Reynolds JJ 1970 phosphate metabolism n/a [From Hioco - source unknown] 47-55 serum phosphate (not The phosphate ion in chronic renal specified) n/a n/a Stanbury SW 1970 failure. n/a [From Hioco - source unknown] 188-208

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Alonso A, Nettleton JA, Ix JH, de Boer IH, Folsom Dietary phosphorus, blood pressure, AR, Bidulescu A, and incidence of hypertension in the Kestenbaum BR, atherosclerosis risk in communities dietary phosphorus' - form Chambless LE & Jacobs study and the multi-ethnic study of unspecified n/a n/a DR 2010 atherosclerosis man Hypertension. 55:776-784 Studies of calcium and phosphorus metabolism. II. The calcium excretion of normal individuals on a low dietary phosphorus' - form Bauer W, Albright F & Aub calcium diet, also data on a case of unspecified n/a n/a JC 1930 pregnancy. various [source unknown] 75-1279 Clinical methods: the history, physical and serum phosphate (not Chapter 198. Serum inorganic laboratory examinations. 3rd edition. Ed. specified) n/a n/a Bansal VK 1990 phosphorus n/a Walker HK, Hall WD, Hurst JW

A study of relationships between bone-related vitamins and minerals, related risk markers, and subsequent mortality in older British people: the Bates CJ, Hamer M & National Diet and Nutrition Survey of serum phosphorus n/a n/a Mishra GD 2012 People Aged 65 Years and Over man Osteoporos Int (2012) 23:457–466

Ethnic differences in dairy and related nutrient consumption among Beydoun MA, Gary TL, US adults and their association with Caballero BH, Lawrence obesity, central obesity, and the The American Journal of Clinical Nutrition. 87: serum phosphorus n/a n/a RS, Cheskin LJ & Wang Y 2008 metabolic syndrome man 1914-1925 Relation of plasma phosphate concentration to renal tubular serum phosphorus n/a n/a Bijvoet OLM 1969 reabsorption of phosphate man Clin. Sci. 37: 23-36 Le probleme calcium-phosphore de serum phosphorus n/a n/a Bock A 2012 l'insuffisance renale man Forum Med Suisse. 12(20-21) 406-409 Serum Phosphorus Concentrations in the Third National Health and de Boer IH, Rue TC, Nutrition Examination Survey American Journal of Kidney Diseases, Vol 53: serum phosphorus n/a n/a Kestenbaum B 2008 (NHANES III) man pp 339-407

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Dhingra R, Gona P, Relations of serum phosphorus Benjamin EJ, Wang TJ, levels to echocardiographic left Aragam J, D'agostino RB, ventricular mass and incidence of European Journal of Heart Failure. 12: 812- serum phosphorus n/a n/a Kannel WB & Vasan RS 2010 heart failure in the community man 818

El-Abbadi MM, Pai AS, Phosphate feeding induces arterial Leaf EM, Yang HY, Bartley medial calcification in uremic mice: phosphate' form not BA, Quan KK, IngallsCM, role of serum phosphorus, fibroblast specified n/a n/a Liao HW & Giachelli CM 2009 growth factor-23, and osteopontin mice Kidney International. 75:1297–1307

Elliot P, Kesteloot H, Appel Dietary Phosphorus and Blood LJ, Dyer AR, Usehima H, Pressure : International Study of dietary phosphorus (source Chan Q, Brown IJ, Zhao L Macro- and Micro-Nutrients and not specified) n/a n/a & Stamler J 2008 blood pressure man Hypertension. 51:669-675

Foley RN, Collins AJ, Serum Phosphorus Levels Associate serum phosphate (not Herzog CA, Ishani A & with Coronary Atherosclerosis in specified) n/a n/a Karla PA 2009 Young Adults man J Am Soc Nephrol. 20: 397-404

Giachelli CM, Jono S, Shioi inorganic phosphate' (form A, Nishizawa Y, Mori K & Vascular Calcification and Inorganic American Journal of Kidney Diseases, Vol 38, not specified) n/a n/a Morii H 2001 Phosphate n/a No 4, Suppl 1 (October). pp S34-S37 phosphorus' (form not specified) n/a n/a Goldman R & Basset SH 1954 Phosphorus excretion in renal failure man [source unknown]: 1623-1628

Harlan WR, Hull AL, Dietary phosphorus and Schomouder RL, Landis Blood pressure and nutrition in serum phosphorus (form JR, Thompson RE & Larkin adults. The national health and American Journal of Epidemiology, Vol 120(1): not specified) N/A N/A FA 1984 nutrition examination survey. Man 17-28

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Harlan WR, Hull AL, High blood pressure in older Dietary phosphorus (form Schmouder RL, Landis JR, Americans. The first national health not specified) N/A N/A Larkin FA & Thompson FE 1984 and nutrition examination survey. Man Hypertension. 6:802-809

The concentration of inorganic Inorganic pyrophosphate Hausmann E, Bisaz S, pyrophosphate in human saliva and (form not specified) N/A N/A Russell RGG & Fleisch 1970 dental calculus Man Archs oral Biol. 15: 1389-1392

Effects of nitrogen, phosphorus, and Dietary phosphorus (form caffeine on calcium balance in not specified) N/A N/A Heaney RP & Recker RR 1982 women Man J Lab Clin Med. 99(1): 46-55 Associations of dietary phosphorus intake, urinary phosphate excretion, Houston J, Smith K, and fibroblast growth factor 23 with Dietary phosphorus (form Isakova T, Sowden N, Wolf vascular stiffness in chronic kidney not specified) N/A N/A M & Gutierrez OM 2012 disease Man Journal of Renal Nutrition (in press)

Serum phosphorus concentrations Ix JH, De Boer IH, Peralta and arterial stiffness among CA, Adeney KL, Duprez individuals with normal kidney Serum phosphorus (form DA, Jenny NS, Siscovick function to moderate kidney disease not specified) N/A N/A DS & Kestenbaum BR 2009 in MESA Man Clin J Am Soc Nephrol. 4:609-615

Relationship of magnesium intake Dietary phosphorus (form Joffres MR, Reed DM & and other dietary factors to blood not specified) N/A N/A Yano K 1987 pressure: the Honolulu heart study Man Am J Clin Nutr. 45: 469-475

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Long-term effects of high phosphate Phosphate (form not Jowsey J, Reiss E & intake on parathyroid hormone levels specified) N/A N/A Canterbury JM 1974 and bone metabolism Dog Acta orthop scand. 45: 801-808 The role of phosphorus in the Serum phosphorus (form development and progression of not specified) N/A N/A Kendrick J & Chonchol M 2011 vascular calcification Man Am J Kidney Dis. 58(5): 826-834

Relation of serum phosphorus levels to ankle brachial pressure index Serum phosphorus (form Kendrick J, Ix JH, Targher (from the third national health and The American Journal of Cardiology. 106: 564- not specified) N/A N/A G, Smits G & Chonchol M 2010 nutrition examination survey) Man 568

Factors which determine the concentration of calcium and of Serum phosphorus (form inorganic phosphorus in the blood not specified) N/A N/A Kramer B & Howland J 1931 serum of rats (second paper) Rat The Journal of Nutrition. 5(1): 39-60 Cojoint effects of serum calcium and Larsson TE, Olauson H, phosphate on risk of total, Hagstrom E, Ingelsson E, cardiovascular, and serum phosphate (not Arnlov J, Lind L & noncardiovascular mortality in the specified) N/A N/A Sundstrom J 2010 community Man Arterioscler Thromb Vasc Biol. 30: 333-339 Linefsky JP, O'Brien KD, Katz R, de Boer IH, Barasch E, Jenny NS, Association of serum phosphate Serum phosphate (form not Siscovick DS & levels with aortic valve sclerosis and Journal of the American College of Cardiology. specified) N/A N/A Kestenbaum B 2011 annular calcification Man 58(3): 291-299

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Relationship between serum Lippi G, Montagnana M, phosphate and cardiovascular risk Serum phosphate (form not Salvagno GL, Targher G & factors in a large cohort of adult Diabetes Research and Clinical Practice. 84:e3- specified) N/A N/A Guidi GC 2009 outpatients Man e5

Meng J, Wassel CL, Kestenbaum BR, Collins Serum phosphorus levels and the Serum phosphate (form not TC, Criqui MH, Lewis CE, spectrum of ankle-brachial index in specified) N/A N/A Cummings SR & Ix JH 2010 older men Man Am J Epidemiol. 171: 909-916

Serum phosphate (form not Novel mechanisms in the regulation specified) N/A N/A Berndt T & Kumar R 2009 of phosphorus homeostasis Man Physiology. 24: 17-25

Unique coexpression in osteoblasts Murshed M, Harmey D, of broadly expressed genes accounts Pyrophosphate (form not Millan JL, McKee MD & for the spatial restriction of ECM specified) N/A N/A Karsenty G 2005 mineralization to bone N/A Genes & Development. 19: 1093-1104

Phosphate (form not The effect of intravenous calcium on Clinical Science Vol 13 (Arnott WM (ed)) Shaw specified) N/A N/A Nordin BEC & Fraser R 1954 phosphate excretion Man & Sons Ltd (London)

Plasma phosphate (form Assessment of urinary phosphate not specified) N/A N/A Nordin BEC & Fraser R 1960 excretion Man The Lancet. April 30: 947-951

Phosphate (form not Biochemical aspects of parathyroid specified) N/A N/A Nordin BEC 1961 function and of hyperparathyroidism Man Advances in Clinical Chemistry. 4: 275-320

Onufrak SJ, Bellasi A, Investigation of gender heterogeneity Cardarelli F, Vaccarino V, in the associations of serum Serum phosphorus (form Muntner P, Shaw LJ and phosphorus with incident coronary American Journal of Epidemiology. 169(1): 67- not specified) N/A N/A Raggi P 2008 artery disease and all-cause mortality Man 77 Onufrak SJ, Bellasi A, Shaw LJ, Herzog CA, Phosphorus levels are associated Serum phosphorus (form Cardarelli F, Wilson PW, with subclinical atherosclerosis in the not specified) N/A N/A Vaccarino V, Raggi P 2008 general poplulation Man Atherosclerosis. 199: 424-431

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Park KS, Chang JW, Kim Lower concentrations of serum TY, Kim HW, Lee EK, Kim phosphorus within the normal range H-S, Yang WS, Kim SB, could be associated with less Serum phosphorus (form Park S-K, Lee SK & Park J calcification of the coronary artery in not specified) N/A N/A S 2011 Koreans with normal renal function Man Am J Clin Nutr. 94: 1465-1470 Serum phosphate (form not Journal of the American College of Cardiology. specified) N/A N/A Rajamannan NM 2011 Serum phosphate concentrations Man 58(3) 299 Plasma, calcium, magnesium, phosphorus, and alkaline Plasma phosphate (form phosphatase levels in normal British not specified) N/A N/A Round JM 1973 schoolchildren Man British Medical Journal. 3: 137-140 The influence of pyrophosphate, condensed phosphates, phosphonates and other phosphate compounds on the dissolution of hydroxyapatite in vitro and on bone Russell RGG, Muhlbauer resorption induced by parathyroid Pyrophosphate (form not RC, Bisaz S, Williams DA hormone in tissue culture and in specified) N/A N/A and Fleisch 1970 thyroparathyroidectomised rats Rat Calc Tiss Res. 6: 183-196

The urinary excretion of inorganic Pyrophosphate (form not Russell RGG & pyrophosphate by normal subjects specified) N/A N/A Hodgkinson A 1966 and patients with renal calculus Man Clin Sci. 31: 51-62

Association of serum phosphorus with left ventricular mass in men and women with stable cardiovascular Serum phosphorus (form Saab G, Whooley MA, disease: Data from the Heart and American Journal of Kidney Diseases. 56(3): not specified) N/A N/A Schiller NB, Ix JH 2010 Soul Study Man 496-505

Serum phosphate (form not Sim J, Smith N, Chung J, Evaluation of serum phosphorus specified) N/A N/A Kalantar-Zadeh K 2012 levels and obesity Man Kidney Res Clin Pract. 31: A16-A96

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Takeda E, Yamamoto H, Phosphate (inorganic and Yamanaka-Okumura H & Dietary phosphorus in bone health organic) N/A N/A Taketani Y 2012 and quality of life Man Nutrition Reviews. 70(6): 311-321

Relation between serum phosphate Serum phosphate (form not Tonelli M, Sacks F, Pfeffer level and cardiovascular event rate in specified) N/A N/A M, Gao Z & Curhan G 2005 people with coronary disease Man Circulation. 112(17): 2627-2633

Phosphorus-containing food Phosphorus (form not Winger RJ, Uribarri J & additives: an insidious danger for Trends in Food Science & Technology. 24: 92- stated) N/A N/A Lloyd L 2012 people with chronic kidney disease Man 102 Influences of dietary phosphorus Yan Q, Tang S, Bamikole variation on nutrient digestion, fecal Phosphorus (form not MA, Han X, Zhou C, Wang endogenous phosphorus output and specified) N/A N/A M, Sun Z, Tan Z 2011 plasma parameters of goats Goat Livestock Science. 142: 63-69 Advances in Nutritional Research, Volume 9, Phosphorus (form not The effects of high phosphorus intake chapter 11 (Preedy VR & Watson RR (Eds)): specified) N/A N/A Calvo M S 1994 on calcium homeostasis Man 183-207. New York: Raven. Present knowledge in nutrition Tenth edition, chapter 13 (Erdman JW Jr & MacDonald IA No IP substances N/A N/A Norman AW & Henry HL 2012 Vitam in D Man (Eds)): 199-213 Present knowledge in nutrition Tenth edition, chapter 14 (Erdman JW Jr & MacDonald IA No IP substances N/A N/A Traber MG 2012 Vitamin E Man (Eds)): 214 Present knowledge in nutrition Tenth edition, chapter 28 (Erdman JW Jr & MacDonald IA No IP substances N/A N/A Weaver CM 2012 Calcium Man (Eds)): 434-447 Amaral AP, Oskouei B, Hu M-C, Moe O, Kuro-o M, Serum phosphate (form not Brand M, Hare J, Wolf M, Fibroblast growth factor 23 induces specified) N/A N/A Faul C 2012 left ventricular hypertrophy Man JACC. 59(13): E1059

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Faul C, Amaral AP, Oskouei B, Hu M-C, Sloan A, Isakova T, Gutierrez OM, Aguillon-Prada R, Lincoln J, Hare JM, Mundel P, Morales A, Scialla J, Fischer M, Soliman EZ, Chen J, Go AS, Rosas SE, Nessel L, Townsend RR, Feldman HI, Sutton MS, Ojo A, Gadegbeku C, Di Marco GS, Reuter S, Kentrup D, Tiemann K, Brand M, Hill JA, Moe OW, Serum phosphate (form not Kuro-o M, Kusek JW, FGF23 induces left ventricular specified) N/A N/A Keane MG and Wolf M 2011 hypertrophy Man The Journal of Clinical Investigation. 121(11):

Gutierrez OM, Januzzi JL, Isakova T, Laliberte K, Smith K, Collerone G, Sarwar A, Hoffmann U, Coglianese E, Christenson Fibroblast growth factor-23 and left Serum phosphate (form not R, Wang TJ, deFilippi C & ventricular hypertrophy in chronic specified) N/A N/A Wolf M 2009 kidney disease Man Circulation. 119(19): 2545-2552

Serum phosphate (form not FGF-23: the rise of a novel specified) N/A N/A Heine GH, Seiler & Fliser D 2012 cardiovascular risk marker in CKD Man Nephrol Dial Transplant. 27: 3072-3081 Serum intact FGF23 associate with Mirza MAI, Larsson A, left ventricular mass, hypertrophy Serum phosphate (form not Melhus H, Lind L, Larsson and geometry in an elderly specified) N/A N/A TE 2009 population Man Atherosclerosis. 207: 546-551 Phosphorus (form not specified) N/A N/A Nordin BEC 1988 Phosphorus Man Journal of Food and Nutrition. 45(3): 62-75

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Parker BD, Schurgers LJ, The associations of fibroblast growth Brandenburg VM, factor 23 and uncarboxylated matrix Christenson RH, Vermeer Gla protein with mortality in coronary Total phosphorus (form not C, Ketteler M, Shlipak MG, artery disease: the Heart and Soul specified) N/A N/A Whooley MA & Ix JH 2010 study Man Ann Intern Med. 152: 640-648 Seiler S, Cremers B, Rebling NM, Hornof F, Jeken J, Kersting S, Steimle C, Ege P, Fehrenz The phosphatonin fibroblast growth M, Rogacev KS, Scheller B, factor 23 links calcium-phosphate Serum phosphate (form not Bohm M, Fliser D, Heine metabolism with left-ventricular specified) N/A N/A GH 2011 dysfunction and atrial fibrillation Man European Heart Journal. 32: 2688-2696 Semba R, Fink JC, Sun K, Serum fibroblast growth factor-23 Cappola AR, Dalal M, and risk of incident chronic kidney Serum phosphate (form not Crasto C, Ferrucci L & disease in older community-dwelling specified) N/A N/A Fried LP 2012 women Man Clin J Am Soc Nephrol. 7: 85-91

Plasma fibroblast growth factor 23, Plasma phosphate (form Taylor EN, Rimm EB, parathyroid hormone, phosphorus, not specified) N/A N/A Stampfer MJ, Curhan GC 2011 and risk of coronary heart disease Man American Heart Journal. 161(5): 956-961

Udell JA, O'Donnell T, Morrow D, Jarolim P, Association of fibroblast growth No IP substances Ormland T, Sloan S, factor (FGF)-23 levels with risk of (measurement of serum Pfeffer M, Braunwald E, cardiovascular events in patients with phosphatonin (FGF-23)) N/A N/A Sabatine M 2012 stable coronary artery disease Man JACC. 59(13): E1480 Mechanisms and clinical Inorganic phosphate (form Zhu D, MacKensie NCW, consequences of vascular Frontiers in ecdocrinology [online] not specified) n/a n/a Farquharson & MacRae VE 2012 calcification Man www.frontiersin.org

Phosphate, pyrophosphate Lampropoulos CE, Osteoporosis - a risk factor for Advance online publication by Macmillan (form not specified) N/A N/A Papaioannou I & D'Cruz DP 2012 cardioivascular disease? Man Publishers Limited Vascular calcification in chronic Phosphate, pyrophosphate kidney disease: mechanisms and Iranian Journal of Kidney Diseases. 5(5): 285- (form not specified) N/A N/A Ossareh S 2011 clinical implications Man 299

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Dhingra R, Sullivan LM, Relations of serum phosphorus and Fox CS, Wang TJ, calcium levels to the incidence of Serum phosphorus (form D'Agostino RB, Gaziano M cardiovascular disease in the not specified) N/A N/A & Vasan RS 2007 community Man Arch Internal Med. 167: 879-885 Serum phosphorus (form Phosphorus comes of age as a not specified) N/A N/A Anon 2007 cardiovascular risk factor Man Arch Internal Med. 167: 873-874 Incidence and progression of Kestenbaum BR, Adeney coronary calcification in chronic Serum phosphate (form not KL, Boer IH, Ix JH, Shlipak kidney disease: the multi-ethnic study specified) N/A N/A MG, Siscovick DS 2009 of atherosclerosis Man Kidney International. 76: -991-998

Kestenbaum B, Sampson JN, Rudser KD, Patterson Serum phosphate levels and Serum phosphate (form not DJ, Seliger SL, Young B, mortality risk among people with specified) N/A N/A Sherrard DJ & Andress DL 2005 chronic kidney disease Man J Am Soc Nephrol. 16: 520-528 Extracellular inorganic phosphate (form not Savica V, Bellinghieri G & Phosphorus-related mechanisms of specified) N/A N/A Santoro D 2007 vascular calcification Man Arch Intern Med. 167(21): 2368 Frisbie SH, Mitchell EJ, World Health Organization No IP substances Dustin H, Maynard DM & discontinues its drinking water Environmental Health Perspectives. 120(6): discussed N/A N/A Sarkar B 2012 guideline for manganese Man 775-778 Phosphorus, Masson et Cie, editeurs, Libraires pyrophosphate (form not del'academie de medecine, 120 Boulevard specified) N/A N/A Labbe M & Fabrykant M 1933 Le Phosphore N/A Saint-Germain, Paris Dietary phosphate modifies lifespan Nephrology Dialysis Transplantation. 27: 3399- sodium phosphate' N/A N/A Bergwitz C 2012 in Drosophila Drosphila 3409 National Nutrition Survey: Nutrient Australian Bureau of Intakes and Physical dietary phosphate' N/A N/A Statistics 1995 Measurements, Australia, 1995 Austrailian bureau of statistics

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Abramowitz M, Munter P, Coco M, Southern W, Serum Alkaline Phosphatase and Lotwin I, Hostetter TH & Phosphate and Risk of Mortality and serum phosphate' N/a N/A Melamed ML 2010 Hospitalization HUMAN Clin j Am Soc Nephrol 5: 1064-1071

No phosphates tested - Brickman AS, Coburn JW, 1,25 Dihydroxy-Vitamin D3 in Normal Vitamin D3 N/A N/A Massry SG & Norman AW 1974 Man and Patients with Renal Failure Annals of internal medicine. 80(2):161-8

The Prevalence and Nutritional Butt S, Leon JB, David CL, Implications of Fast Food Serum phosphate Chang H, Sidhu S & Sehgal Consumption Among Patients measured as an endpoint N/A N/A AR 2007 Receiving Hemodialysis humans The National Kindney Foundation, Inc

Chen TC, Castillo L, inorganic phosphate - Korycka-Dahl M & DeLuca Role of Vitamin D Metabolites in various substance id n/a n/a HF 1974 Phosphate Transport of Rat Intestine rat Journal of Nutrition 104(8):1050-60

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Serum Phosphorus and Chonchol M, Dale R, Cardiovascular Mortality in Ty·pe 2 The American Journal of Medicine. 122:380- serum phosphate' N/A N/A Schrier RW & Estacio R 2009 Diabetes human 386 phosphate' n/a n/a Fitzgerald FT 1978 Hypophosphatemia [unknown source]

Calcium-phosphate levels and cardiovascular disease in community- Foley RN, Collins AJ, dwelling adults: The Atherosclerosis phosphate' n/a n/a Ishani A & Karla PA 2008 Risk in Communities (ARIC) Study humans Am Heart J; 156:556-63

Isakova T, Guitierrez O, Postprandial Mineral Metabolism and Shah A, Castaldo L, Secondary Hyperparathyroidism in serum phosphate' N/A N/A Holmes J, Lee H & Wolf M 2008 Early CKD J Am Soc Nephrol 19: 615-623 Calcium and phosphate metabolism: An overview in health and in Kidney Stones: Medical and Surgical phosphorus' N/A N/A Lemann J 1996 calciumstone formers Management

Matrix Extracellular Marks J, Churchill LJ, Phosphoglycoprotein Inhibits phosphate' N/A N/A Debnam ES & Unwin RJ 2008 Phosphate Transport n/a J Am Soc Nephrol 19: 2313-2320

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Factors influencing the intake and Mataix J, Aranda P, Lopez- plasma levels of calcium, Jurando M, Sanchez C, phosphorus and magnesium in serum phosphate' n/a n/a Planells E & Llopis J 2006 southern Spain humans Eur J Nutr. 45: 349-354

Nutrition and Phosphorus - New progress and problem - . serum phosphate' n/a n/a Obi Y & Hamano T 2012 Phosphate and the risk of mortality. N/A Clin Calcium

Thatte L, Oster JR, Singer I, Bourgoigne JJ, Fishman Review of the literature: severe phosphorus' N/A n/a LM & Roos BA 1995 hyperphosphatemia human Am J Med Sci. 310(4): 167-174 WATER POLLUTION STUDIES Federal Aid Project #F-243R-5 Toxicity of Manganese to Early-Life Stage and Fry of Brook Trout (Salvelinus jontinalis) and Rainbow Trout (Oncorhynchus mykiss) in manganese sulphate - not Davis PH, Brinkman S & Water Hardnesses of 30 and 150 Colorado Division of Wildlife, Fish Research IP but read-across? n/a n/a McIntyre 1998 mg/L fish Section, Fort Collins, Colorado

NTP Technical Report on the toxicology and carcinogenesis NTP TR-428. U.S. DEPARTMENT OF studies of manganese (II) sulphate HEALTH AND HUMAN SERVICES Public manganese sulphate - not monohydrate (CAS No. 10034-96-5) Health Service IP but read-across? n/a n/a NTP 1993 in F344/N rats and B6C3F1 mice rats, mice National Institutes of Health

Heine GH, Nangaku M & Calcium and phosphate impact European Heart Journal serum phosphate' n/a n/a Fliser D 2012 cardiovascular risk humans doi:10.1093/eurheartj/ehs353

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Standing Committee on the Scientific Evaluation of Dietary Reference Intakes Dietary Reference Intakes for Food and Nutrition Board calcium, phosphorus, magnesium, Institute of Medicine. ISBN: 0-309-52130-0, phosphates n/a n/a FNB 1997 vitamin D and fluoride n/a 448 pages.

Relationships between bone mineral Brot C, Jorgenson N, density, serum vitamin D metabolites Madsen OR, Jensen LB & and calcium:phosphorus intake in Journal of Internal Medicine 1999; 245: serum phosphorus' n/a n/a Sorenson OH 1999 healthy perimenopausal women human 509]516 phosphorus '- form not Age Considerations in Nutrient Needs Journal of the American College of Nutrition, specified n/a n/a Heany RP 1996 for Bone Health: Older Adults human Vol. 15, No. 6, 575-578

The relationship between habitual dietary phosphorus and calcium intake, and bone mineral density in Ito S, Ishida H, Uenishi K, young Japanese women: a cross- dietary phosphorus' n/a n/a Murakami K & Sasaki S 2011 sectional study human Asia Pac J Clin Nutr 2011;20 (3):411-417 Risking public health by approving some health claims? – The case of phoshorus' n/a n/a Pravst I 2011 phosphorus human Food Policy 36 (2011) 726–728

Dietary Relerence Intakes: The new basis lor recommendations Yates AA, Schlicker SA, for calcium and related nutrients, B JOURNAL OF THE AMERICAN DIETETIC phoshorus' n/a n/a Suitor CW 1998 vitamins, and choline ASSOCIATION. 98(6): 699-706 Chevalley T, Rizzoli R, Nydegger V, Slosman D, Effects of Calcium Supplements on Rapin C-H, Michel J-P, Femoral Bone Mineral Density and Vasey H and Vertebral Fracture Rate in Vitamin-D- phosphate' n/a n/a Bonjour J-P 1994 Replete Elderly Patients HUMAN Osteoporosis Int 4:245-252

Discussion Paper on the setting of European Communities, maximum and minimum amounts for phosphorus' n/a n/a 2006 2006 vitamins and minerals in foodstuffs n/a

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Hyper-phos (mixture of K Goldsmith RS, Bartos H, Phosphate Supplementation as and Na phosphates), Hyper- Hulley SB, Ingbar SH & an Adjunct in the Therapy of Multiple phos K (K phosphate) n/a n/a Moloney WC 1968 Myeloma human Arch Intern Med/Vol 122, 128-133

Low calcium:phosphorus ratio in Kemi VE, Karkkainen habitual diets affects serum MUM, Rita HJ, Laaksonen parathyroid hormone concentration MML, Outila TA & Lamberg- and calcium metabolism in healthy British Journal of Nutrition (2010), 103, dietary P' n/a n/a Allardt CJE 2010 women with adequate calcium intake human 561–568 Habitual high phosphorus intakes Kemi VE, Karkkainen and foods with phosphate additives MUM, Rita HJ, Viljakainin negatively affect serum parathyroid HT, Laaksonen MML, hormone concentration: a cross- Outila TA & Lamberg- sectional study on healthy dietary P' n/a n/a Allardt CJE 2009 premenopausal women human Public Health Nutrition: 12(10), 1885–1892

Effects of dietary factors on skeletal integrity in adults: calcium, dietary P' n/a n/a Chinn. HI. LSRO Report 1983 phosphorus, vitamin D and protei LSRO Report The Effect of Differing Dietary Pettifor JM, Marie PJ, Sly Calcium and Phosphorus Contents MR, de Bruyn D, Ross F, on Mineral Metabolism and Bone Isdale JM, de Klerk WA & Histomorphometry in Young Vitamin dietary P' n/a n/a Van Der Walt WH 1984 D-Replete Baboons monkeys Calcif Tissue Int (1984) 36:668-676

Persistently elevated parathyroid hormone secretion and action in Calvo M S, Kumar R & young after four weeks of ingesting Journal of Clinical Endocrinology and dietary phosphate n/a n/a Heath H 1990 high phosphorus, low calcium diets human Metabolism. 70 (5):

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Optimal nutrition: calcium, Proceedings of the Nutrition Society, 58, pp serum phosphate n/a n/a Cashman KD & Flynn A 1999 magnesium and phosphorus. various 477487 Circadian variation in ionized calcium Calvo MS, Eastell R, Offord and intact parathyroid hormone: KP, Bergstrahl EJ & Burrit evidence for sex differences in Journal of Clinical Endocrinology and serum phosphate n/a n/a MF 1991 calcium homeostasis human Metabolism. 72(1) 69-76 Elevated secretion and action of serum parathyroid hormone in young adults consuming high phosphorus, Calvo MS, Kumar K & low calcium diets assembled from Journal of Clinical Endocrinology and dietary phosphorus n/a n/a Heath H 1988 common foods human Metabolism. 66(4): 823-829 Orthophosphate Therapy Decreases Urinary Calcium Excretion and Van Der Berg CJ, Kumar Serum 1,25 Dihydroxyvitamin D R, Wilson DM, Heath H & Concentrations in Idiopathic Journal of Clinical Endocrinology and serum phosphate n/a n/a Smith LH 1980 Hypercalciuria human Metabolism. 51(5): 998 - 1001 Relative bioavailability of different phosphorus supplements in broiler phosphorus n/a n/a Rao SVR & Reddy VR 2001 and layer chicken diets chicken J. Anim. Sci. 2001. Vol. 14, No.7: 979-985 Phosphorus and its compounds. Vol [handbook] Interscience publishers. ISBN various n/a n/a Van Wazer 1958 1: Chemistry n/a unknown Phosphorus and its compounds. Vol 2: Technology, biological functions [handbook] Interscience publishers. ISBN various n/a n/a Van Wazer 1958 and applications n/a unknown

Yamamoto KT, Robinson- Cohen C, de Oliveira MC, Kostina A, Nettleton JA, Ix JH, Nguyen H, Eng J, Lima dietary phosphorus JAC, Siscovick DS, Weiss Dietary phosphorus is associated International Society of Nephrology (unknown) n/a n/a NS & Kestenbaum B 2012 with greater left ventricular mass human (http://www.kidney-international.org)

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The secreted Klotho protein restores phosphate retention and suppresses accelerated aging in Klotho mutant European Journal of Pharmacology - Article in Dietary phosphate n/a n/a Chen TH et al 2012 mice mice press FNCE hot topic: Is phosphorus the Food Navigator USA.COM - Pub 15 October Dietary phosphate n/a n/a Watson E 2012 new trans fat? N/A 2012

Effect of calcium supplements on risk of myocardial infarction and Serum phosphate n/a n/a Bolland MJ et al 2010 cardiovascular events: meta-analysis N/A BMJ 2010;341:c3691

Serum phosphate levels and the risk of cardiovascular disease and metabolic syndrome: A double-edged Diabetes Research and Clinical Practice. Serum phosphate n/a n/a Park W et al 2008 sword N/A 84:119-125

Serum calcium, phosphorus and cardiovascular events in post- International Journal of Cardiology 149 (2011) Serum phosphate n/a n/a Slinin Y et al 2011 menopausal women N/A 335–340

Striker GE, Grosjean F and Phosphate and CVD : It's All in Arterioscler Thromb Vasc Biol. 2011;31:1951- Serum phosphate n/a n/a Vlassara H 2011 What's on the Table n/a 1952 Inorganic Phosphate Accelerates the Migration of Vascular Smooth Muscle Cells: Evidence for the Involvement Serum phosphate n/a n/a Rangrez AY et al 2012 of miR-223 N/A PLOS ONE. Vol 7. Issue 10

Walsh JP, Divitini ML and Serum phosphate n/a n/a Knuiman MW 2012 Calcium and cardiovascular disease N/A Journal unknown [In Polish] 'Phosphate fertiliser Roczniki Aktukmii Rol ńicztj w Pomaniu- Serum phosphate n/a n/a Ponikiewska T et al 1980 effects on field cows cows CXIX(1980)

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Some studies on the formation in vivo of pyridoxal phosphate in rats Serum phosphate n/a n/a Chatterjee AJ and Datta SD 1972 receiving high-fat diet rats The Journal of vitaminology. 18:189-193 Chapter 4: Nutrition and Serum phosphate n/a n/a Draper HH and Bell RR 1979 Osteoporosis N/A Book chapter - source unknown

Serum phosphate n/a n/a Shroff R 2012 Phosphate is a vascular toxin N/A Pediatric Nephrology Experimental Studies on Serum phosphate n/a n/a KrooK L et al 1975 Osteoporosis N/A Meth. Achiev. exp. Pathol., vol. 7, pp. 72-108

Serum phosphate and hip bone mineral density as additional factors for high vascular calcification scores in a community-dwelling: The São Serum phosphate n/a n/a Figueiredo CP et al 2013 Paulo Ageing & Health Study (SPAH) N/A Bone 52 (2013) 354–359 A problem for ESRD patieents and Serum phosphate n/a n/a Harum P 2012 the public N/A Nephrology News & Issues • July 2012

Phosphorus Additives in Food and Serum phosphate n/a n/a Uribarre J 2009 their Effect in Dialysis Patients N/A CJASN August 2009 vol. 4 no. 8 1290-1292

Eddington H, Sinhal D and Vascular calcification in chronic Serum phosphate n/a n/a Kalra PA 2009 kidney disease: A clinical review N/A Journal of Renal Care. 35(1):45-50 Calcium, Phosphorus, Parathyroid Hormone, and Cardiovascular Disease in Hemodialysis Patients: Slniin Y, Foley R and The USRDS Waves 1, 3, and 4 Serum phosphate n/a n/a Collins AJ 2005 Study N/A J Am Soc Nephrol 16: 1788–1793

Serum phosphate and mortality in Serum phosphate n/a n/a Eddington H et al 2010 patients with chronic kidney disease N/A Clin J Am Soc Nephrol 5: 2251–2257

Longitudinal Relationships among Coronary Artery Calcification, Serum CJASN ePress. Published on November 5, Serum phosphate n/a n/a Tuttle KR and Short RA 2009 Phosphorus, and Kidney Function N/A 2009 Hidden Sources of Phosphorus in the Typical American Diet: Does it Matter Serum phosphate n/a n/a Urribarre J and Calvo M 2003 in Nephrology? N/A Journal unknown

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Effects of phosphate binders in Serum phosphate n/a n/a Block GA et al 2012 moderate CKD N/A J Am Soc Nephrol 23: 1407–1415, Phosphate Binders: New Study Raises Questions about Safety and Serum phosphate n/a n/a Weaver J 2012 Effi cacy N/A Nephrology times. 5(8):16-17 mixture: tetracalcium phosphate, α-tricalcium In vitro genotoxicity of calcium phosphate, sodium Altay MA, Erturk C, phosphate-based bone substitute glycerophosphate and Kocyigit A, Taskin A & material on human peripheral polydimethylsiloxane N/A N/A Celik H 2013 mononuclear leukocytes N/A Acta Medica Mediterranea. 29:723-729 Role of Hyperphosphatemia and 1,25- Dihydroxyvitamin D in Vascular Stubbs JR, Liu S, Tang W , Calcification and Mortality in Zhou J, Wang Y, Yao X, & Fibroblastic Growth Factor 23 Null serum phosphate N/A N/A Quarles LD 2007 Mice mice J Am Soc Nephrol 18: 2116–2124, Biological Acute Toxicity: Determining the Effects of TFT-LCD Pollutants on Daphnia N/A N/A N/A Wu M 2013 magna in Aquatic Systems Daphnia UNKNOWN magnesium phosphate Zhang B, Yu Y, Changsen Ames test on magnesium phosphate cement N/A N/A L 2009 cement bacteria Gu yu guanjie sunshang zazhi. 10 DOUBLE-BLIND, VEHICLE- CONTROLLED RANDOMIZED TWELVE-MONTH J. POIRIER, H. SEMPLE,J. NEURODEVELOPMENTAL DAVIES, R. LAPOINTE, TOXICITY STUDY OF M. DZIWENKA, M. HILTZ COMMON ALUMINUM SALTS IN Aluminium citrate N/A N/A AND D. MUJIBI 2011 THE RAT rat Neuroscience 193: 338–362 Domingo JL, Gómez M, Lack of teratogenicity of aluminium Aluminium hydroxide N/A N/A Bosque A, Corbella J 1989 hydroxide in mice mice Life Sciences, Vol. 45, pp. 243-247 Developmental toxicity evaluation of Gómez M, Domingo JL, oral aluminium in rats: influence of Neurotoxicology and Teratology, Vol. 13 pp Aluminium N/A N/A Llobet JM 1990 citrate rats 323-328 Hirata-Koizumi M, Fujii S, Ono A, Kirose A, Imai T, Ogawa K, Ema Two-generation reproductive toxicity Aluminium sulfate N/A N/A M,Nishikawa A 2011 study of aluminium sulfate in rats rats Reproductive Toxicology 31 (2011) 219-230

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

The biological behaviour and bioavailability of aluminium in man, with special reference to studies employing aluminium-26 as a tracer: Aluminium N/A N/A Priest N D 2004 review and study update human J. Environ. Monit., 2004, 6, 375-403

Lack of maternal and developmental toxicity in mice given high doses of Colomina MT, Gómez M, aluminium hydroxide and ascorbic Pharmacology and Toxicology 1994, 74, 236- Aluminium hydroxide N/A N/A Domingo JL, Corbella J 1994 acid during gestation mice 239 Evaluation of the maternal and developmental toxicity of aluminium Gómez M, Bosque MA from high doses of aluminium Aluminium hydroxide N/A N/A Domino JL, Llobet JM 1990 hydroxide in rats rats Vet Hum Toxicol 32(6) December 1990 Embryotoxic and teratogenic effects Patertain JL, Domingo JL, of aluminium nitrate in rats upon oral Aluminium nitrate N/A N/A Llobet JM and Corbella J 1988 administration rats Teratology 38: 253-257

Priest ND, Talbot RJ, The bioavailability of Al-labelled Aluminium citrate and Austin JG, Day JP, King aluminium citrate and aluminium aluminium hydroxide N/A N/A SJ, Fifield K, Cresswell RG 1996 hydroxide in volunteers human BioMetals, 1996, 9: 221-228 The Effect of Phosphate Ore on the Immunomodulatory Activities of Aladaileh S, Alnaimat S, Haemocytes of the Marine Snail, Alhroob A, Al-Tawaha AR Planaxis sulcatus (Born, 1778) in the Rock phosphate N/A N/A & Odat N 2014 Gulf of Aqaba, Jordan marine snail Global Veterinaria 12 (3): 410-419, 2014

Effect of some inorganic and organic anions on aluminium toxicity to a European Journal of Experimental Biology, Aluminium N/A N/A Rao TVRK & Kumar A 2014 fresh water fish, Channa punctatus fish 2014, 4(4):126-130

Ota Y, Hasumura M, Okamura M, Takahashi A, Chronic toxicity and carcinogenicity Ueda M, Onodera H, Imai of administered ammonium sulphate Food and Chemical Toxicology 44 (2006) 17- Ammonium sulphate n/a n/a T, Misumori K & Hirose M 2006 in F344 rats rat 27 Zelma B, Day N, N/A N/A N/A Swiatnicka J & Banasik R 1987 Larynx Cancer Risk Factors human Neoplamasa 34(2):223-

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Cellular biocompatibility and stimulatory effects of calcium metaphosphate on osteoblastic Park EK, Lee YE, Choi JY differentiation of human bone marrow- Calcium metaphosphate N/A 77489-25-9 et al 2004 derived stromal cells cells Biornaterials 25 (2004) 3403-3411

Review: Biological effects of inorganic phosphate - Hong SH, Park SJ, Lee S, inorganic phosphate: potential signal The Journal of Toxicological Sciences. 40(1): various substance id n/a n/a Kim S & Cho MH 2015 of toxicity various 55-69 Effects of Inhalation of Red Phosphorus/Butyl Rubber red phosphorus / butyl Aryani C, Vana SN, Bradof Combustion Products on Aveolar rubber n/a n/a JN, Sherwood R 1988 Macrophage Responses in Rats rat Journal of Applied toxicology Research and development on inhalation toxicologic evaluation of red phosphorus / butyl red phosphorus/butyl rubber N/A: rubber n/a n/a Aryani C 1983 combustion products. Phase II rat www.dtic.mil/dtic/tr/fulltext/u2/a158323.pdf Research and development on inhalation toxicologic evaluation of red phosphorus / butyl red phosphorus/butyl rubber N/A: rubber n/a n/a Aryani C 1984 combustion products. Phase III rat www.dtic.mil/dtic/tr/fulltext/u2/a173549.pdf Research and development on inhalation toxicologic evaluation of red phosphorus / butyl red phosphorus/butyl rubber N/A: rubber n/a n/a Aryani C 1984 combustion products. Phase IV rat www.dtic.mil/dtic/tr/fulltext/u2/a189254.pdf No IP substances tested - Morita T, Nagaki T, Clastogenicity of low pH to various looked at low pH n/a n/a FukundaI & Okumura K 1992 cultured mammalian cells CHO Mutation Research. 268: 297-305

Bittsanszky A, Pilinszky K, ammonium n/a n/a Gyulai G, Komives T 2014 Overcoming ammonium toxicity n/a doi:10.1016/j.plantsci.2014.12.005 Mutagenic Evaluation of Compound Sodium Ferric FDA 73-82 010045871 Sodium Ferric Yeast and Pyrophosphate N/A N/A Brusick D 1975 Pyrophosphate Bacteria NTIS Teratologic evaluation of FDA 73-82 ferric sodium ferric sodium pyrophosphate in mice pyrophosphate N/A N/A Brusick D 1975 and rats. mice and rats NTIS

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Dietary phosphate - from Dairy Products and Prostate Cancer dairy products n/a various Newmark HL, Heany RP 2010 Risk humans Nutrition and Cancer, 62(3), 297–299 Ovarian Activity and Reproductive Tallam SK, Ealy AD, Bryan Performance of Dairy Cows Fed Dietary phosphate n/a ? KD & Wu Z 2005 Different Amounts of Phosphorus cows J. Dairy Sci. 88:3609-3618

Effect of Three Calcium: Phosphorus Ratios on Performance of Growing Dietary phosphate n/a ? Ricketts RE, Campbell JR 1970 Holstein Steers cows J. Dairy Sci. 53(7): 898 -903 Smith AM, Holck GL & 1. Calcium, Phosphorus and Vitamin Dietary phosphate n/a ? Spafford HB 1966 D cows J. Dairy Sci. 49: 239-243 De Los Angeles Aguilar M, α-tricalcium phosphate Pina MC, Lopex RM, Cytotoxic and genotoxic effects of the (90%), hydroxyapatite, Rodriguez L & Driessens exposure of human lymphocytes to a Journal of Applied Biomaterials & calcium carbonate N/A N/A FCM 2005 calcium phosphate cement in vitro N/A Biomechanics 2005; Vol. 3 no. 1: 29-34 Gergulova R, Tepavitcharova S, Rabadijiva D, Sexanova K, Biomimetric Synthesis of Modified ion modified calcium Ilieva R, Alexandrova R & Calcium Phosphate Fine powders N/A N/A Abdonova-Lilova B 2013 Powders and Their in Vitro Studies CELLS [UNKNOWN] concentrated super Evaluation of phosphated egg shell phosphate, diammonium Struwe FJ, Sullivan TW and fertilizer phosphates in turkey phosphate n/a, 18 N/A and Kuhl HJ 1976 starter diets1,2,3 turkey Poultry Sci. 55:1691-1699 Various Lide D R. CRC Handbook of chemistry and Various Various 2009 physics N/A CRC Handbook of chemistry and physics Studies on the biological value of various various various Gillis MB et al 1954 inorganic phosphates. N/A J. Nutr. 52:115-125. Hydrolysis of condensed phosphates polyphosphate' during aerobic biological sewage 'orthophosphate' Various Various Finnstein M and Hunter J 1967 treatment. microbes Water Research, Pergamon Press, 1: 247-254 Hydrolysis of condensed phosphates pyrophosphate, during aerobic biological sewage tripolyphosphate various various Finstein MS and Hunter JV 1967 treatment. N/A Water Research, Pergamon Press, 1: 247-254 Averbuch Pouchot MT and various various various Durif A 1991 Crystal chemistry of oligophosphates N/A Annu. Rev. mater. Sci. 21:65-92 Averbuch-Pouchot MT and various various various Durif A 1996 Topics in Phosphate Chemistry N/A N/A

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

The Merck Index, An Encyclopaedia Twelfth Edition Merck & Co., Inc. Whitehouse Various VARIOUS Various Budavari S et al 1996 of Chemicals, Drugs and Biologicals Station, NJ. Crystal Chemistry of Condensed various various various Durif A 1995 Phosphates. N/A Plenum Press, New York. various Ebel JP Action Physiologique et Toxicologique des Phosphates Various various 1958 Condensés. Impremerie Nationale J.P.831041 : 57-97 The utilization by the Chick of various various various Gillis MB et al 1949 phosphorus from different sources. chick J. Nutr. 35(2):195-207

GRAS (generally recognised as safe) Franklin Institute Research Laboratories 806- Various various Various GRAS 1973 food ingredients - Phosphates. C3378-01-7301. Various Various n/a Lewis RJ Lewis – Sax Dangerous Pro perties Volume 18

Food Antioxidants. technological, various various various Madhavi DL, et al 1996 toxicological and health perspectives N/A N/A various various various Mellor JW 1912 Modern Inorganic Chemistry N/A N/A Utilization of phosphorus from Motzok I, Arthur D and various phosphate supplements in various various various Branion HD 1956 chicks chicken Poultry Sci. 35: 627-649 Nonenzymic hydrolysis at phosphate Various phosphates Various Various osterheld 1972 tetrahedra N/A

Solubilities of Inorganic and Metal Organic Compounds. A Compilation of Quantitative Solubility Data from Third Edition, Volume 1, New York, D. Van Various substances various various Siedell A 1940 the Periodical Literature. N/A Nostrand Company Inc Dritter Band. Wassrige Lusung und sodium phosphates' various various Thomsen J 1888 N/A hydratbildung Structure and properties of the condensed phosphates. X. general various various various Van Wazer JR 1955 structural theory N/A J Am Chem Soc, 77: 6140-6144 Structure and properties of the condensed phosphates. I. some general considerations about various various various Van Wazer JR 1950 phosphoric acids N/A J Am Chem Soc, 72(2): 639-644

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Study Organism Substance Sub ID CAS Nr. Authors Object [title of the article] Source [journal name] Year tested

Structure and properties of the condensed phosphates. II. A theory of the molecular structure of sodium various various various Van Wazer JR 1950 phosphate glasses N/A J Am Chem Soc 72(2): 644-647

Existence of ring phosphates higher various various various Van Wazer JR 1956 than the tetrametaphosphate N/A J Am Chem Soc 78: 1772 Toxicological evaluation of some extraction solvents and certain other FAO Nutrition Meetings Report Series No. 48A. Various Various N/A WHO 1970 substances Various WHO/FOOD ADD/70.39 various various Lang K. et al 1958 Condensed Phosphates in Foods N/A Textbook Phosphates and superphosphates, phosphorus and Encyclopaedia of occupational health and compounds, phosphoric safety third (revised) edition (ISBN 92-2- acid Various Various Parmeggiani L (Ed) 1983 Volume 2: L-Z 103291-4) Phosphorus and phosphorus compounds, Hazardous materials toxicology: Williams & Wilkins, 428 East Preston Street, organophosphate Sullivan JB and Krieger GR clinical principles of environmental Baltimore, Maryland 21202, USA (ISBN 0-683- insecticides Various Various (Eds) 1992 health 08025-3) La medication phosphoree envisagee au point de vue des echanges Various Various Various Gilbert A and Posternak S 1903 nutritifs de l'organisme L'Oeuvre med-chir 36: 48 tripolyphosphate. Hydrolysis of condensed phosphates 'pyrophosphate' Various Various Shannon JE and Lee GF 1966 in natural waters N/A Air & Wat. Pollut. Int. J 10, 735-756 Food additives in Europe 2000 - status of safety assessments of food additives presently permitted in the Various Various N/A Anon ~2000 EU. Various Food additives in Europe 2000 Bibra Toxicology Advice Phosphoric Acid and Common Various various Various and Consulting 1993 Inorganic Phosphates various Toxicity Profile. The structural chemistry of Various phosphates various various Corbridge DEC 1974 phosphorus. N/A Elsevier Scientific Publishing Company.

Phosphates; proposed affirmation of and deletion from GRAS status as Various Various Various Federal Register 1985 direct and human food ingredients. rats Vol 44, No.10, 244

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Http://www.codexalimentarius.net/gsfaonline/gr GFSA Online Food Additive Group oups/details.html?id=18&lang-en Various various Various GFSA 2008 Details for Phosphates. n/a Evaluation of the health aspects of Federation of American Societies for Various Various Various Jelleff Carr C. 1975 phosphates as food ingredients. N/A Experimental Biology. PB262651.

Hawley's Condensed Chemical Hawley's condensed chemical dictionary, 15th Various various Various Lewis RJ 2007 Dictionary N/A edition. Nonenzymic hydrolysis at phosphate Various various various Osterheld RK 1972 tetrahedral. N/A WHO IPCS INCHEM INTERNATIONAL PROGRAMME ON Toxicological evaluation CHEMICAL SAFETY WORLD food additives JECFA no HEALTH ORGANIZATION 17 TOXICOLOGICAL EVALUATION OF CERTAIN VETERINARY DRUG RESIDUES IN FOOD WHO FOOD Various Various Various 1982 ADDITIVES SERIES 17. 1982. effect of single superphosphate fertiliser on survival and respiratory dynamics of Nile Tilapia, Oreochromis niloticus Single superphosphate Omoregie E, Ajima MNO, (Actinopterygh: Acta Ichthyologica et piscatoria. 39(2): 103- (SSP) Keke RI and Wieski K 2009 perciformes:cichildae) Fish 110 effects of phosphorous supply on Abdolzadeh A, Wang X, growth, phosphate concentration and No IP substance - refers to Veneklaas EJ and Lambers cluster-root formation in three Phosphate only H 2010 Lupinus species plants Annals of Botany. 105:365-374

Dietary and genetic evidence for No IP substance - refers to Ohnishi M and Razzaque phosphate toxicity accelerating Phosphate only MS 2010 mammalian aging mice The FASEB Journal. Responses of Dairy Cows Fed Alfalfa De Boer G, Buchanan- Silage Supplemented with monoammonium Smith JG, Macleod GK & Phosphorus, Copper, Zinc, and phosphate Walton JS 1981 Manganese cows J Dairy Sci 64:2370-2377

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Influence of Particle Solubility on the David C. Dorman, Melanie Delivery of Inhaled Manganese F. Struve, R. Arden James, to the Rat Brain: Manganese Sulfate Marianne W. Marshall, Carl and Manganese Tetroxide U. Parkinson, and Brian A. Pharmacokinetics Following Toxicology and Applied Pharmacology 170, No IP substances tested Wong 2001 Repeated (14-Day) Exposure rat 79–87 Manganese Inhalation by Rhesus Erikson, K.M., Dorman, Monkeys is Associated with Brain No IP substances tested - D.C., Lash, L.H., Aschner, Regional Changes in Biomarkers of MnSO4 M. 2007 Neurotoxicity Rhesus Monkey Tox Sci. 97:459-466. Duration of airborne-manganese exposure in rhesus monkeys is associated with brain regional No IP substances tested - Erikson KM, Dorman DC, changes in biomarkers of MnSO4 Lash LH and Ashner M 2008 neurotoxicity Rhesus Monkey NeuroToxicology 29 (2008) 377–385

MANGANESE TOXICITY IN PASTURE LEGUMES I. EFFECTS No IP substances tested - Truong NV, Wilson GL and OF CALCIUM AND PHOSPHORUS MnSO4 Andrew CS 1971 LEVELS IN THE SUBSTRATE n.a Plant and Soil 34, 309-330 (1971)

Expert group on vitamins EVM UK Expert Group Review of various and minerals Secretariat 2003 Phosphorus N/A EVM Review No IP substances: Clement Internation Toxicological profile for fluorides, Agency for Toxic Substances and Disease Fluorides Corporation 1993 hydrogen fluoride and fluorine various Registry. U.S public health service. Hill WL, Hendricks SB, Jefferson ME & Reynolds Composition of defluorinated defluorinated phosphate DS 1937 phosphate n/a Ind. Eng. Chem., 29(11): 1299-1304 Cade R, Conte M, Zauner sodium phosphate C, Mars D, Peterson J, Effects of phosphate loading on 2,3- (unspecified - states Lunne D, Hommen & diphosphoglycerate and maximal Medicine and Science in Sprots and Exercise. neutral buffered) Packer D 1984 oxygen uptake human 18(3): 263-266 Leyhausen G, Lorenz B, Zhu H, Geurtsen W, JOURNAL OF BONE AND MINERAL Inorganic linear Bohnensack R, Muller Inorganic Polyphosphate in Human RESEARCH polyphosphate WEG & Schroder HC 1998 Osteoblast-like Cells n/a - cells Volume 13, Number 5, 1998

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phosphorus homeostasis in normal health and in chronic kidney disease patients with special emphasis on dietary phosphorus Uribarre J 2007 dietary phosphorus intake various Seminars in dialysis. 20 (4): 297-301

Zhang Y, Post W, Dalal D, Bansal S, Blasco- Colmenares E, Jan De Serum 25-Hydroxyvitamin D, Beur S, Alonson A, Calcium, Phosphorus, and Soliman EZ, Whitsel EA, Electrocardiographic QT Interval Brugada R, Tomaselli GF & Duration: Findings from NHANES III phosphate' Guallar E 2011 and ARIC human J Clin Endocrinol Metab 96: 1873–1882, Toxicity assessments of antimony, barium, berylikium and manganese for development of ecological soil screening levels (ECO-SSL) using manganese sulphate - not Kuperman RG, Checkai enchytraeid reproduction benchmark Edgewood Chemical Biological Center - IP but read-across? RT, Phillips CT & Simini M 2002 values published online ECBC-TR-324 Influence of Phosphorus Intake on Excretion and Blood Plasma and Valk H, Sebek LBJ & Saliva Concentrations of Phosphorus dietary P Beynen AC 2002 in Dairy Cows cows J. Dairy Sci. 85:2642-2649 Brodison JA, Goodall EA, Influence of dietary phosphorus on Armstrong JD, Given DI , the performance of lactating dairy Gordon FJ, McCaughey cattle Dietary P WJ & Todd JR 1989 cows J. agric. Sci., Camb. (1989), 112, 303-311.

Layton JB, Klemmer PJ Sodium Phosphate Does Not Christiansen CF, Bomback Increase Risk For Acute Kidney AS, Baron JA, Sandler RS, Injury After Routine Colonoscopy, Clinical Gastroenterology and Hepatology. oral sodium phosphate Ksirsagar AV 2014 Compared With Polyethylene Glycol Accepted manusript.

Goldman, A.S. & Yakovac Salicylate intoxication and congenital Ammonium chloride W.C. 1964 abnormlatiies rat Archives of Environmental Health, 8: 648-656

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Oral (drinking water) developmental toxicity study of ammonium Int J Toxicol. 2001 Jul-Aug; 20(4): 199-205. York RG, Brown WR, perchlorate in New Zealand white Argus Research Laboratories Inc., Horsham, Ammonium perchlorate Girard MF, Dollarhide JS 2001 rabbits rabbits Pennsylvania, USA Chironomus tentans (larval midge) and Schubaeur-Berigan MK, Influence of the pH on the toxicity of lumbriculus Monson PD, West CW, Ankley ammonia to Chironomus tentans and variegatus Ammonium chloride GT. 1995 Lumbriculus variegatus (oligochaete) Environ. Toxicol. Chem. 14(4): 713-717 Biomphalaria havanensis at 3 life stages; Toxicity evaluation of ammonium eggs, juveniles sulphate and urea to three (2-3 mm) and Tchounwou PB, Englande developmental stages of freshwater adults (5-6 Archives of Environmental Contamination and Ammonium sulphate AJ Jr, Malek EA 1991 snails mm). Toxicology Site-specific acute and chronic toxicity of ammonia to Daphnia Daphnia Ammonium chloride Gerisch FM, Hopkins DL 1986 magna Straus. Environ. Toxicol. Chem. 5: 443-447 Short term toxicity testing on Journal of Water Pollution Control Fed. 37(9): Ammonium hydroxide Dowden BF & Bennett HJ 1965 invertebrates Daphnia 1308-1316 Sulphuric acid and laryngeal cancers - sulphuric acid? Cookfair 1985 abstract /no title human society for epidemiologic research: abstracts

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