Indium, Caesium Or Cerium Compounds for Treatment of Cerebral Disorders

Europaisches Patentamt 298 644 J European Patent Office Oy Publication number: 0 A3 Office europeen des brevets

EUROPEAN PATENT APPLICATION

© Priority: 07.07.87 GB 8715914 © Applicant: EFAMOL HOLDINGS PLC Efamol House Woodbridge Meadows © Date of publication of application: Guildford Surrey GU1 1BA(GB) 11.01.89 Bulletin 89/02 @ Inventor: Horrobin, David Frederick © Designated Contracting States: c/o Efamol House Woodbridge Meadows AT BE CH DE ES FR GB GR IT LI LU NL SE Guildford Surrey GU1 1BA(GB) Inventor: Corrigan, Frank ® Date of deferred publication of the search report: c/o Argyll & Bute Hospital 14.11.90 Bulletin 90/46 Lochgilphead, Argyll PA3T 8ED Scotland(GB)

© A method of treatment of schizophrenia or other chronic cerebral disorder in which cerebral atrophy is shown, is characterised in that one or more assimilable or pharmaceutically acceptable indium caesium or cerium compounds is associated with a pharmaceutically acceptable diluent or carrier.

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CD 00 O>

Xerox Copy Centre PARTIAL EUROPEAN SEARCH REPORT Application number European Patent J which under Rule 45 of the European Patent Convention Office shall be considered, for the purposes of subsequent EP 88 30 5895 proceedings, as the European search report

DOCUMENTS CONSIDERED TO BE RELEVANT Citation of document with indication, where appropriate, Relevant CLASSIFICATION OF THE ategory of relevant passages to claim APPLICATION (Int. CI.")

X PSYCHOPHARMACOLOGY, vol. 84, 1984, A 61 K 31/20 61 31/28 pages 80-84, Springer Verlag; A K R. BOSE et al.: "Central depressant A 61 K 33/24 action of cesium i:n mice"

* The whole document, especially page 83, "discussion" *

1-5

GB-A-2 148 713 (CENTURY LABORATO- RIES, INC.)

* Page 2, lines 10-20; claims * 1-5

EP-A-0 181 689 (EFAMOL LTD.) TECHNICAL FIELDS- SEARCHED (Int. Cl.*) * Claims * 1-5 A 61 K ./•

INCOMPLETE SEARCH The Search Divis.on cons.ders that the present E^opean patent appicat.on does not comPiywth Patent Convention to such an extent hat it s not possible to carry the provisions of the European claims._ out a meaningful search into the state of the art on the basis of some of the Claims searched completely: Claims searched incompletely: 1 f 7 Claims not searched: Reason for the limitation of the search: See sheet -B-

Place of search Date of completion of the search Examinsr THE HAGUE 05-04-1990 KLAVER invention CATEGORY OF CITED DOCUMENTS T : theory or principle underlying the E : earlier patent document, but published on, or alone after the filing date X : particularly relevant if taken cited in the application Y : particularly relevant if combined with another D : document document of the same category L : document cited for other reasons A : technological background T I family, corresponding O : non-written disclosure 4 member of the i same patent P : intermediate document document Application number JVYj European Patent J» PARTIAL EUROPEAN SEARCH REPORT JO))) Office EP 88 30 5895 -2-

DOCUMENTS CONSIDERED TO BE RELEVANT CLASSIFICATION OF THE APPLICATION (Int. Cl.*) ategory Citation of document with indication, where appropriate, ol relevant Relevant passages to claim

US-A-4 182 754 (G.A.H. BONADIO)

* Claims * 1-5

BRAIN, vol. 98, 1975, pages 49-64; A. HOCK et al.: "Trace element concentration in human brain, activation analysis of cobalt, iron, rubidium, selenium, zinc, chromium, silver cesium, antimony, and scandium" TECHNICAL FIELDS * Pages 49-51,59-62 * 1-5 SEARCHED (Int CM)

EPO Form 1505.3 06.78 European Patent J Office

CLAIMS INCURRING FEES

The present European patent application comprised arthe time of filing more than ten claims. search has been ( — I All claims fees have been paid within the prescribed time limit. The present European report drawn up for all claims. I — I Only part of the claims fees have been paid within the prescribed time limit. The present European search report has been drawn up for the first ten claims and for those claims for which claims fees have been paid. namely claims: |~~| No claims fees have been paid within the prescribed time limit. The present European search report has been drawn up for the first ten claims.

LACK OF UNITY OF INVENTION v The Search Division considers that the present European patent application does not comply with the requirement of unity of invention and relates to several inventions or groups of inventions. namely:

1. Claims 1-5: Use of indium, caesium or cerium compounds for the treatment of schizophrenia.

2. Claims 6-12: A new compound and its use in therapy.

has r—i All further search fees have been paid within the fixed time limit. The present Europetn search report been drawn up for all claims. i—i Only part of the further search fees have been paid within the fixed time limit. The present European search '— ' in report has been drawn up for those parts of the European patent application which relate to the inventions respect of which search fees have been paid. namely claims: Hg None of the further search fees has been paid within the fixed time limit. The present European search report has been drawn up for those parts of the European patent application which relate to the invention first mentioned in the claims. namely claims: 1~ 5 J) EP 88 30 5895 Sheet -E-

MEANINGFUL SEARCH NOT POSSIBLE OR INCOMPLETE SEARCH Reason for limitation of the search: Claims 1-5 have been searched as if they had been drafted in the correct form: Use of a compound for the manufacture of a medicament for the therapeutic application (see official Journal of the EPO3/1985 pages 64-70) It is not clear what is meant by: - "other chronic cerebral disorders in which..." - "...an assimilable and pharmaceutically acceptable compound" (e.g. claim 1)(EPC Art. 84).