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Herpes Simplex Virus (HSV) Infection in Men with Genital Ulcer Disease (GUD)—As Observed in Dhaka Medical College Hospital

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Herpes Simplex Virus (HSV) Infection in Men with Genital Ulcer Disease (GUD)—As Observed in Dhaka Medical College Hospital Original article Herpes Simplex Virus (HSV) Infection in Men with Genital Ulcer Disease (GUD)—as Observed in Dhaka Medical College Hospital Mamun SA1, Chowdhury MAH2, Khan RM3, Sikder MAU4, Hoque MM5. Abstract Introductions Genital herpes clinically underestimated because symptoms or sign occur only in some infection detected serologically. Genital herpes is a contagious recurrent infection caused by Prevalence of HSV subtypes in microbial etiology of Genital the herpes simplex virus (HSV) of which there are two Ulcer Disease (GUD) in men, their association with clinical subtypes HSV-1 and HSV-2. The infection is usually sign, complex of GUD and high-risk behavior were acquired by sexual contact and like other genital ulcer assessed. One hundred men with first episodes of genital diseases increases the risk of HIV transmission and ulcers were prospectively studied for serological evidence of acquisition1-2. Genital herpes clinically underestimated syphilis (RPR and TPHA; T.pallidum IgM and IgG because symptoms or sign occur in less then 40% of the antibodies) and Polymerase Chain Reaction (PCR) proven infections detected serologically3. Around 90-96% HSV-2 chancroid and herpes. Demographic and epidemiological seropositive women cannot recognize the initial infection4. data were obtained in a standard interview. Positive syphilis Although the virus spread through contact with lesion or serology observed in 11 cases, H. ducreyi detected in 65 secretion but individuals those never have any symptoms cases and Herpes Simplex Virus in 13 cases. Among the and do not know that they are infected with the HSV can PCR proven infections HSV type-2 detected in 7 cases, HSV also transmit the virus to others5. Because the asymptomatic type-1 in 4 cases and both HSV type-1 & 2 in 2 cases. Most shedding of small amount of virus at the site of infection, in of the HSV infections (92.3%) found as mixed infection with genital or oral secretion or from inapparent lesion may be H. ducreyi. There was one PCR detected genital herpes case fairly common but is sufficient to infect a sex partner6-7. that was clinically undetermined. Among the PCR proven The genital herpes lesions appear as small red bumps that HSV infections clinical sign complex of genital herpes may develop into blisters. Over a period of days they observed in one case, which had mixed microbial etiology. become encrusted, form a scab and eventually heal without HSV infection was more prevalent in married than scarring. These manifestations are hardly present when unmarried men (25.0% vs. 8.3%; P<0.05) and associated patient seek treatment. Data collected in STD clinics in with early age promiscuous activity, multiple sexual partner, USA revealed that 80% of HSV-2 infections were and sex with commercial sex workers and past infection unrecognized forms8. with STDs. Presence of underdiagnosed HSV infection in Therefore the study was conducted to determine the men with GUD stress on the need for clinical suspicion of prevalence of HSV subtypes in microbial etiology of GUD multiple infections. Patient with GUD should be carefully in men, their association with clinical sign complex of GUD evaluated for HSV infection. and high-risk behavior. Methods 1. Shameem Al Mamun Skin and VD specialist, Dhaka Mohanagar General Hospital. Patients: The study was carried out in the skin & VD 2. M Abu Hena Chowdhury Assistant Professor, Department of Dermatology and Venereology, outpatient department at Dhaka Medical College hospital Banga Bandhu Sheikh Mujib Medical University. and at the Laboratory science division of ICDDR, B, Dhaka. 3. Rashed Mohammad Khan One hundred consecutive men with genital ulcers were Associate Professor, Department of Skin and VD included in the study. Each patient was ensured Sir Salimullah Medical College. 4. Md. Akram Ullah Sikder confidentiality and anonymity and asked to participate in Professor, Department of Dermatology and Venereology, the study. Demographic and epidemiological data were Banga Bandhu Sheikh Mujib Medical University obtained in a standard interview. 5. M Mujibul Hoque, Professor and Ex. Head of the Department, Department of Skin and VD, Dhaka Medical College Hospital. Clinical etiological diagnosis: All patients underwent a physical examination of the external genitalia and inguinal ORIGINAL ARTICLE region before sample for laboratory analysis were taken. cases where IgM antibodies to T. pallidum were diagnosed. The clinical, etiological diagnosis was made prior any All patients with a positive IgM test were screened for the knowledge of the laboratory result. Following criteria were presence of the rheumatoid factor (serodia-RA, Fujinebio, used-a painless indurated clean based ulcer was considered Tokyo, Japan). as syphilis, a deep undermined purulent tender ulcers as Detection of C. donovani: with the back of the haemostylet Chancroid. Genital herpes was clinically diagnosed when smear from the ulcer was prepared for specific staining and multiple grouped vesicles were present or when ulcers were microcopy. very superficial and tender. Genital scabies pyogenic ulcer when lesions were extremely itchy, multiple, purulent, HIV testing: HIV testing was unlinked and anonymous. tender and/or burrow present especially on the genitalia and Serum samples were tested with an enzyme-linked adjacent area and characteristics distribution of scabies immunosorbent assay (ELISA) (Vironostika HIV-mixt, lesion elsewhere in the body. Donovanosis was considered Organon Teknika) and positive results were confirmed by a when the lesion had a beefy aspect. When clinical feature line immunoassay (LIA tek HIV III, Organon Teknika). did not corresponds to one of these criteria the clinical Quality control was carried out using standard quality diagnosis was classified as undetermined. No attempts were control sera for HIV provided by the National Reference made to clinically identified other causes of GUD or mixed Centre for HIV/AIDS, Christian Medical College, Vellore, infection. India. Laboratory diagnosis: Samples were collected from the Microscopic detection of the scabies mite was not ulcer base after cleaning the lesion with sterile gauge and performed since it is not expected to be fruitful in scraping back of the haemostylet and 5ml of venous blood were of heavily infected lesion. collected for syphilis serology. Total and differential WBC Statistical Analysis counts were performed in all cases. The Pearson chi-square and the Yate’s corrected chi-square Detection of H. ducreyi by PCR technique: a dacron tipped test (when appropriate) were applied to assess the swab was subsequently rubbed against the ulcer base and differences in proportions for statistical significance. stored in a sterile 1 molar phosphate buffered saline solution Independent t test was done to measure difference between (PBS; 50mM sodium phosphate, 0.15M sodium chloride; the means for significance. The statistical analysis was pH 7.5), but without sodium chenodeoxycholate9 and stored performed using the statistical software SPSS version 10.1. at –700c until shipped to the laboratory. Three different primers were used for the detection of the H. ducreyi Results genome10-12. Only sample giving a positive result with three Socio-demographic Characteristics: summarized in Table- primers were considered as being positive. 1. The average age of the sampled GUD population was Detection of herpes simplex virus by PCR technique: 24.7 ± 6.8 years and most of them belonged to 16-25 years detection and typing of herpes simplex virus was performed age group, on the other hand HSV more frequently detected with two different13 primers. Only samples giving a positive in 21-25 years age group and the mean age of the HSV result with two primers were considered as being positive infected GUD patient was 23.9 ± 5.0 years Most of the and further typing of herpes simplex virus was done GUD patients were unmarried (72%) where most of the according to Kimura14. HSV infected men were married (53.8%) and HSV prevalence was also high in married than unmarried GUD Serology for syphilis: for the diagnosis of syphilis, serum patients (25.0% vs. 8.3%). Civil status and HSV infection specimens were tested with the rapid plasma reagin test showed significant relation (P=0.046). A large number of (RPR nosticon, Organon Teknika, Turnhoul, Belgium) GUD patients (54) were least educated (0-5 years) but HSV which was titrated till the end point, as well as with the detected more in educated persons and HSV prevalence was T.pallidum haemoagglutination assay (TPHA nosticon, also high in those have 11-15 years education (29.4%). As Organon, Teknika). T. pallidum IgG and IgM antibodies like GUD patients many HSV infected patients were worker were detected with an ELISA technique (Treponema or laborer but HSV infection was more prevalent in pallidum IgM EIA, Treponema pallidum IgG comfort EIA, businessmen (4/16, 25.0%). Most of the GUD patients Meddens Diagnostics, Brummen, The Netherlands). Patients belonged to poor socioeconomic class (61%), in contrary a were considered as having primary syphilis if the RPR was large proportion of HSV infected GUD patients represented reactive in the presence of a positive TPHA test and in all 56 2010 Volume 22 Number 02 ORIGINAL ARTICLE Table-1: Socio- demographic Characteristics of GUD Patients and patients harboring HSV infection in DMCH, Dhaka, Bangladesh. GUD Population HSV harboring HSV Prevalence Characteristics Infection in GUD N = 100 % N = 13 % Population (%) Age group 16 – 20 Years 30 30.0 3 23.1 3.3 21 – 25 Years 38 38.0 6 46.2 15.8 26 – 30 Years 19 19.0 3 23.1 15.8 > 30 Years 13 13.0 1 7.7 7.7 Average Age (Mean ± SD) 24.7 ± 6.8 Years 23.9 ± 5.0 Years P = 0.693 Civil Status 72.0 46.2 Single 72 6 8.3 28.0 53.8 Married 28 7 25.0 Education (Years) 27.0 23.1 0 27 3 11.1 27.0 15.4 1 - 5 27 2 7.4 27.0 23.1 6 - 10 27 3 11.1 17.0 38.5 11 - 15 17 5 29.4 2.0 0.0 > 15 2 0 0.0 20.0 15.4 Occupation 20 2 10.0 16.0 30.8 Govt.
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