Datasheet Inhibitors / Agonists / Screening Libraries A DRUG SCREENING EXPERT

Product Name : Norbinaltorphimine dihydrochloride Catalog Number : T12241 CAS Number : 113158-34-2 Molecular Formula : C40H45Cl2N3O6 Molecular Weight : 734.71

Description: Norbinaltorphimine dihydrochloride is a potent and selective antagonist of κ opioid receptor.

Storage: 2 years -80°C in solvent; 3 years -20°C powder;

Receptor (IC50) κ opioid receptor

In vivo Activity The KOR antagonist, Norbinaltorphimine(norBNI), had weak and inconsistent effects on THC-induced taste avoidance in adolescent rats in that norBNI both attenuated and strengthened taste avoidance dependent on dose and trial. norBNI had limited impact on the final one-bottle avoidance and no effects on the two-bottle preference test. Interestingly, norBNI had no effect on THC-induced taste avoidance in adult rats as well.

Reference 1. Flax SM, et al. Effect of norbinaltorphimine on ∆⁹-tetrahydrocannabinol (THC)-induced taste avoidance in adolescent and adult Sprague-Dawley rats. Psychopharmacology (Berl). 2015 Sep;232(17):3193-201. 2. Jackson KJ, et al. Effects of the kappa opioid receptor antagonist, norbinaltorphimine, on stress and drug-induced reinstatement of nicotine-conditioned place preference in mice. Psychopharmacology (Berl). 2013 Apr;226(4):763-8.

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