Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_000950095Cyc: Photobacterium kishitanii ATCC BAA-1194 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari

a dipeptide a dipeptide molybdate 1-(β-D uracil uracil an aromatic thiamine diphosphate ribofuranosyl) (R)- cob(I)inamide formate xanthine xanthine sn-glycerol a tripeptide a tripeptide thiamine thiamine molybdate L-fucose arsenite amino acid thiamine nicotinamide pantothenate cob(I)alamin 3-phosphate predicted ABC ThiP RS13435 ThiQ transporter ModC RS10760 PanF BtuD FucP FocA ArsB RS11845 RS18065 GlpT DtpA DtpA RS19470 of molybdate

1-(β-D formate thiamine diphosphate (R)- cob(I)inamide L-fucose sn-glycerol thiamine thiamine molybdate ribofuranosyl) arsenite xanthine xanthine a tripeptide a tripeptide an aromatic thiamine pantothenate cob(I)alamin uracil uracil 3-phosphate amino acid molybdate nicotinamide a dipeptide a dipeptide

Cofactor, Carrier, and Vitamin Biosynthesis Storage Compound Biosynthesis Amine and Polyamine Degradation 6 γ ATP superpathway of pyrimidine Nucleoside and Nucleotide Degradation N -(3-methylbut- 3-phenyl-2- ditrans,octacis- a nascent trimethylamine L-alanyl- -D- a [protein] an [amino-group biotin biosynthesis I polyhydroxybutanoate biosynthesis a sulfurated a peptidoglycan a reduced a [glutamine- an N-modified NADP + FMNH a nucleoside 4-hydroxy- an L-asparaginyl- [2Fe-2S] iron-sulfur ubiquinol-8 biosynthesis thiamine diphosphate salvage II thiamine phosphate formation from Fatty Acid and Lipid Biosynthesis superpathway of N-acetylglucosamine, 2-en-1-yl)- tyr peptidoglycan 2 L-threo-3-phenylserine glutamyl-L-lysyl- C-terminal glu carrier protein]- ubiquinol-8 biosynthesis superpathway of flavin biosynthesis I (bacteria and plants) superpathway of heme b biosynthesis from uroporphyrinogen-III Fermentation mixed acid fermentation biosynthesis deoxyribonucleosides degradation purine nucleotides degradation II (aerobic) S-methyl-5'-thioadenosine oxopropanoate undecaprenyldiphospho- N-oxide ATP triphosphate RNA ATP Asn superpathway of menaquinol-8 biosynthesis I [sulfur carrier] 37 TorC protein synthetase]- aminoacyl-[tRNA] L-threonine [tRNA ] cluster biosynthesis (early decarboxylation) (late decarboxylation) demethylmenaquinol-8 biosynthesis I pyrithiamine and oxythiamine (yeast) degradation IV N-acetylmannosamine and N- adenosine N-acetyl-(N- (meso-DAP D-alanyl-D-alanine biotin L-glutamate C-terminal-γ- 4-amino-2-methyl-5- ADP 2'-deoxycytidine acetylneuraminate degradation in tRNA containing) L-tyrosine (L-glutamate 5- a malonyl-[acp] all-trans- uroporphyrinogen-III palmitate biosynthesis acetyl-CoA phosphoenolpyruvate 1,6-anhydro-N- acetylglucosaminyl) chorismate pyrimidinemethanol pyrithiamine phosphatidylglycerol biotin-carboxyl carrier F0F1 ATP S-methyl-5'- aspartate/ γ oxygen- semialdehyde-2-N-acetyl- malonyl-ACP O- L-cysteine desulfurase 4-hydroxybenzoate octaprenyl chorismate chorismate GTP (type II fatty acid synthase) AMP N-acetylneuraminate acetylmuramyl- muramoyl-L-alanyl- - trimethylamine- aminoacyl- low specificity penicillin- DNA- low specificity 30S aminoacyl- biosynthesis II (non-plastidic) protein assembly acetyl-CoA C- cytidine thioadenosine tRNA (N6-isopentenyl β insensitive gamma- methyltransferase diphosphate bifunctional uroporphyrinogen synthase: atpC 5'-methylthioadenosine/ L-alanine tyrosine/aromatic D-isoglutaminyl-N-( - membrane-bound N-oxide bifunctional [glutamate- tRNA L-threonine binding directed RNA L-threonine bifunctional biotin- ribosomal tRNA yl)-L-glutamate BioC: bioC isochorismate hydroxymethylpyrimidine isochorismate thiaminase a [biotin carboxyl- acyltransferase phosphoenolpyruvate pyruvate kinase atpD atpG atpA deaminase: S-adenosylhomocysteine adenosine(37)-C2)- aminotransferase: D-asparaginyl)-L-lysyl- -ammonia ligase]- NADPH polymerase -[acetyl-CoA- glutamyl- cysteine decarboxylase: hemE an acetoacetyl-[acp] pyrimidine 5'- N-acetyl-D- amidase lytic murein reductase hydrolase: aldolase: protein aldolase: protein hydrolase: a malonyl-[acp] methyl ester 4-hydroxybenzoate synthase MenF: kinase/ synthase MenF: GTP cyclohydrolase II: tenA DHAP carrier protein]-L-lysine FadA: fadA carboxylase: ppc PykF: pykF atpH atpF atpE cdd thymidine nucleosidase: methylthiotransferase UB40_RS12270 D-alanyl-D-alanine adenylyl-L-tyrosine nitroreductase: subunit carboxylase] phosphate desulfurase nucleotidase: yjjG mannosamine AmpD: ampD transglycosylase TorA: torA pth UB40_RS04990 2: mrdA UB40_RS04990 S6--L- pth an [amino-group octaprenyltransferase: UB40_RS07745 all-trans-octaprenyl phosphomethylpyrimidine UB40_RS07745 II: UB40_RS09535 4-amino-2-methyl-5- NAD(P)H- [+ 3 isozymes] pyruvate kinase: pyk UB40_RS16225 UB40_RS12305 MiaB: miaB phosphorylase/ nfsA alpha: rpoA synthetase/ reductase: sulfur coproporphyrinogen III 3-oxoacyl- bifunctional biotin- [+ 4 isozymes] IMP aspartate/ MltC: mltC trimethylamine- aminoacyl- low-specificity [+ 2 isozymes] low- glutamate aminoacyl- carrier protein]- beta-ketoacyl-ACP ubiA 4-hydroxybenzoate diphosphate kinase: thiD [+ 3 isozymes] pyrimidinemethanol dependent 2'-deoxyuridine pyrimidine/purine superpathway of purine deoxyribonucleosides degradation N-acetylmannosamine succinate [glutamate-- [+ 2 isozymes] biotin operon argC acceptor isochorismate isochorismate ACP -[acetyl-CoA- acetoacetyl-CoA oxaloacetate F0F1 ATP [+ 2 isozymes] ditrans,octacis- tyrosine/aromatic monofunctional [+ 4 isozymes] N-oxide tRNA L-threonine [+ 3 isozymes] specificity ligase: rimK tRNA C-terminal-γ- synthase II: fabF 2,5-diamino-6-(5-phospho-D- glycerol-3- nucleoside MTR kinase: dehydrogenase, a peptidoglycan ammonia-ligase] repressor: subunit bifunctional reductase carboxylase] pyruvate synthase: atpC adenosine GMP IMP undecaprenyldiphospho- aminotransferase: biosynthetic reductase hydrolase: aldolase: ltaE L-alanyl-γ-D- L-threonine hydrolase: (5-phospho- beta-ketoacyl-ACP 4-hydroxy-3- 2-succinyl-6- HMP-P ribosylamino)pyrimidin-4(3H)-one oxygen-independent oxygen-dependent phosphate phosphorylase: UB40_RS09810 hydrophobic pentapeptide adenylyltransferase: UB40_RS20745 30S CsdE: csdE 4-hydroxybenzoate 2-succinyl-6- hydroxymethylpyrimidine FabG: fabG synthetase/ acetoacetyl- atpD atpG atpA UB40_RS02070 + coproporphyrinogen coproporphyrinogen dehydrogenase: UB40_RS15775 dehydrogenase: N-acetyl-D- N-acetyl-(N- peptidoglycan a mature a nascent TorA: torA arfB FMN NADPH H glutamyl-L- D-ala aldolase: ribosomal arfB L-glutamyl)- synthase I: fabB [+ 2 isozymes] octaprenylbenzoate hydroxy-2, 4- octaprenyltransferase: hydroxy-2, 4- bifunctional kinase/ biotin operon CoA reductase: malate UB40_RS12665 2'-deoxyguanosine adenosine pyrimidine 5'- membrane anchor glnE RNA bifunctional 5-(2-hydroxyethyl) III oxidase: hemN oxidase: hemF 3-oxoacyl- gpsA thymidine guaB mannosamine acetylglucosaminyl)muramate transglycosylase: peptidoglycan peptidoglycan lysyl-D-alanine ltaE protein L-glutamate F0F1 ATP 4-hydroxy-3- cyclohexadiene- cyclohexadiene- diaminohydroxyphosphoribosylaminopyrimidine dehydrogenase: mdh protein: sdhD 3-(4- + + ubiA hydroxymethylpyrimidine -4-methylthiazole oxythiamine phosphomethylpyrimidine ACP sn-glycerol repressor: UB40_RS11405 formate C- atpF atpE atpB 2'-deoxyadenosine deaminase: nucleotidase: yjjG 6-phosphate mtgA (meso-DAP benzaldehyde biotinyl-5'- H H a 3-oxoglutaryl-[acp] methyl ester an S-sulfanyl-[L- polyprenylbenzoate 1-carboxylate 1-carboxylate deaminase/5-amino-6-(5-phosphoribosylamino) (3R)-3- phosphorylase: hydroxyphenyl) phe with (L-alanyl- gly S6--L- synthase kinase/ kinase: thiD UB40_RS20745 acetyltransferase: pflB UB40_RS12685 pyrimidine/purine UB40_RS06105 [+ 4 isozymes] an oxidized trimethylamine a [glutamine an N-modified an uncharged Asn cysteine desulfurase] hydroxyethylthiazole reductase 3-phosphate deoA XMP putative N- N 6 -(3-methylbut- γ-D-glutamyl- containing) with adenylate glutamate asn tRNA decarboxylase: ubiD synthase: menH 4-hydroxy-3- synthase: menH uracil reductase RibD: ribD D-ribulose 5-phosphate thiaminase protoporphyrinogen IX protoporphyrinogen IX a [biotin carboxyl- hydroxybutanoyl- poly-[(R)-3- (S)-malate pyruvate TorC protein amino acid tRNA glycolaldehyde 3-oxoacyl-ACP phosphomethylpyrimidine kinase: thiM FabG: fabG formate C- (R)-lactate nucleoside pyrimidine/purine acetylmannosamine- 5'-deoxyadenosine 2-en-1-yl)-2- met an unsulfurated a peptidoglycan di-trans,octa-cis meso-2,6- GlcNAc terminus synthetase]-O gly ligase: rimK scaffold 2-succinyl-5- HMP-P glycerol-3- CoA hydroxybutanoate] ATP 4 reductase FabG: fabG octaprenylbenzoate kinase: thiD 2-succinyl-5- II: tenA carrier protein]-N acetyltransferase: pflB phosphorylase: thymine inosine guanosine pyrimidine 5'- 6-phosphate [sulfur carrier] -undecaprenyl -(5'-adenylyl) 2-octaprenylphenol 4-methyl-5-(2- 5-amino-6-(5-phospho-D-ribosylamino)uracil bifunctional 3,4- phosphate 1-O- 6 adenosine nucleoside (methylsulfanyl) dimer (E. faeciums) diaminopimeloyl- F0F1 ATP protein for enolpyruvoyl-6- 4-hydroxy-3- enolpyruvoyl-6- a (3R)-3- -biotinyl-L-lysine class II fumarate + + 5-(2-hydroxyethyl) UB40_RS15775 nucleotidase: yjjG 2-epimerase: 37 diphosphate -L-tyrosine H H 3-oxoacyl-ACP iron-sulfur hydroxy-3-cyclohexene- phosphooxyethyl) dihydroxy-2-butanone- bifunctional menaquinone- menaquinone- hydroxybutanoyl-[acp] acyltransferase class I poly(R)- hydratase: deaminase: phosphorylase: adenosine D-alanine) a [protein] C- synthase 2-octaprenylphenol octaprenylbenzoate HMP-PP hydroxy-3-cyclohexene- bifunctional -4-methylthiazole uridine pyrimidine/purine pyrimidine/purine UB40_RS09815 reductase FabG: fabG cluster 1-carboxylate thiazole 4-phosphate synthase/ hydroxymethylpyrimidine dependent dependent PlsY: plsY hydroxyalkanoic UB40_RS06625 UB40_RS06105 UB40_RS15775 [+ 4 isozymes] in tRNA tetrapeptide terminal α-L- 6-hydroxylase: 5-hydroxylase: ubiH 1-carboxylate diaminohydroxyphosphoribosylaminopyrimidine 3-hydroxyacyl- acetyl-CoA formate phosphorylase: pyrimidine/purine nucleoside nucleoside N-acetyl-D- a (3R)-3-hydroxyglutaryl- assembly: iscU 2-succinyl-6- glutathione- GTP cyclohydrolase hydroxyethylthiazole kinase/ protoporphyrinogen IX protoporphyrinogen IX acid synthase: [+ 2 isozymes] glutamate-α- UB40_RS14150 3,4-dihydroxy-5-all- 2-succinyl-6- deaminase/5-amino-6-(5-phosphoribosylamino) [acyl-carrier- glycerol-3- a [biotin carboxyl- fumarate hydratase: udp nucleoside phosphorylase: phosphorylase: glucosamine an S-sulfanyl-[cysteine hydroxy-2, 4- thiamine peroxide II: UB40_RS16465 kinase: thiM phosphomethylpyrimidine dehydrogenase: hemG dehydrogenase: hemG UB40_RS11390 xanthosine L-glutamate H + RS08805 H + [acp] methyl ester 3-(all-trans trans-octaprenylbenzoate hydroxy-2, 4- uracil reductase RibD: ribD protein] phosphate 1-O- UB40_RS01810 citrate synthase: UB40_RS15775 UB40_RS15775 6-phosphate desulfurase]-[disordered- phosphate redox reactions kinase: thiD carrier-protein dimer]- phosphate bifunctional formate 2'-deoxyinosine phosphorylase: cyclohexadiene- cyclohexadiene- bifunctional 3,4- 4-methyl-5-(2- acyltransferase 6 class I poly(R)- UB40_RS00890 3-hydroxyacyl- -octaprenyl) synthase: thiE dehydratase N -biotinyl-L-lysine fumarate acetyltransferase: pta acetaldehyde- hydrogenlyase UB40_RS15775 [+ 2 isozymes] [+ 2 isozymes] N-acetylglucosamine- form scaffold 1-carboxylate octaprenyldihydroxybenzoate 1-carboxylate 5-amino-6-(5-phospho-D-ribitylamino)uracil dihydroxy-2-butanone- phosphooxyethyl) PlsB: plsB 6 ACP dehydratase benzene-1,2-diol GSSG HMP-PP FabA: fabA acetyl-CoA acetyl-CoA hydroxyalkanoic 6-phosphate ditrans,octacis- a peptidoglycan with a [protein]- an O - ditrans,octacis- ditrans,octacis- trimethylamine a [bis(guanylyl β-D-fructofuranose a guanine 2445 RNase II poly-A queuosine at N-acetyl-α- protein] complex synthase: menH methyltransferase: ubiG thiamine thiazole a 1-acyl-sn CoA/alcohol complex: pyrimidine/purine [+ 2 isozymes] pyrimidine/purine a heme(III)-bound a reduced phosphoenol an L-cysteinyl- FabZ: fabZ bifunctional 2- synthase: menH 4-phosphate synthase/ acid synthase: citrate deacetylase: nagA undecaprenyldiphospho- (L-alanyl-γ-D-glutamyl- a CcmAB complex methylguanine undecaprenyldiphospho- undecaprenyldiphospho- molybdopterin) cys L-allo-threonine γ-L-glutamyl- gly glu position 34 D-muramoyl- 3',5'-ADP H + RS04740 H + [cysteine desulfurase]-S- (1R,6R)-6-hydroxy-2- phosphate (1R,6R)-6-hydroxy-2- 5-amino-6-(5-phospho- [+ 2 isozymes] -glycerol 3- carboxylase carboxylase succinate dehydrogenase: adhE UB40_RS14810 nucleoside hypoxanthine guanine nucleoside CcmCDE complex L-cysteine TorY protein N-oxide 1-phosphate in 23S rRNA substrate mRNA dGDP pyruvate [tRNA Cys ] polyprenyl-6- 3-methoxy-4-hydroxy-5-all- GTP cyclohydrolase lipoate salvage II phaC acetyl phosphate N-acetyl-(N-acetyl-β-D- L-lysyl-D-alanyl-D- in DNA cofactor D-alanine of a tRNA Asp L-alanine(1-) 3-hydroxyacyl-[acyl- sulfanylcysteine:[acceptor succinylcyclohexa-2,4- D-ribitylamino)uracil carboxyltransferase biotin dehydrogenase/ bifunctional phosphorylase: [+ 2 isozymes] N-acetyl-(N- N-acetyl-(N- bifunctional 3'(2'),5'- hydroxyphenol trans-octaprenylbenzoate synthase: thiE succinylcyclohexa-2,4- II: UB40_RS09545 thiamine a (2E)-but-2-enoyl-[acp] phosphate uracil 2-deoxy-α-D- phosphorylase: glucosaminyl)muramoyl- alanine) pentapeptide chaperone]- carrier-protein] protein]-cysteine diene-1-carboxylate glutathione- phosphatase YigB: yigB a [lipoyl-carrier subunit beta: carboxylase fumarate reductase aconitate hydratase UB40_RS15775 D-glucosamine acetylglucosaminyl) acetylglucosaminyl) 23S rRNA bisphosphate methylase/3- diene-1-carboxylate phosphate protoporphyrin IX 1-acyl-sn-glycerol- poly-[(R)-3- acetate kinase: acetaldehyde CO H ribose 1-phosphate UB40_RS15775 L-alanyl-γ-D-glutamyl-L- methylated-DNA-- γ L-cysteine fructose ribonuclease dehydratase sulfurtransferase: 6 UB40_RS13960 subunit: accC iron-sulfur: frdD frdC 2 2 6-phosphate cytochrome c muramoyl-L-alanyl- muramoyl-L-alanyl- -D- trimethylamine- (guanine(2069)-N(7) low specificity glutathione 1,6-anhydro-N- nucleotidase + + o-succinylbenzoate disulfide o-succinylbenzoate 1-deoxy-L-glycero-tetrulose 4-phosphate synthase: thiE protein]-N -[(R 3-phosphate 2/2-methylisocitrate [+ 2 isozymes] [+ 2 isozymes] bisphosphate R: rnr tRNA aminoacyl- H RS04745 H FabA: fabA UB40_RS15535 demethylubiquinol 3- thiamine phosphate ARP NAD de novo biosynthesis crotonyl-[acyl- a [carboxyl-carrier hydroxybutanoate] UB40_RS15975 frdA UB40_RS18250 phosphopentomutase: α lysyl-D-alanyl-D-alanine biogenesis heme- [protein]-cysteine S- γ-D-isoglutaminyl- isoglutaminyl-L-lysyl- N-oxide )-methyltransferase L-threonine synthase: pyruvate acetylmuramyl- CysQ: cysQ synthase: menC reductase: synthase: menC thiamine deferrochelatase/ )-lipoyl]-L-lysinelipoamidase: acyltransferase: dehydratase: acnB alcohol 2-deoxy- -D-ribose 1-phosphate aldolase: exoribonuclease glutamyl- tRNA a [cysteine desulfurase]- O-methyltransferase I (from aspartate) carrier-protein] protein dimer]-N 6 - deoB urea degradation II transporting methyltransferase: N-(β-D-asparaginyl) (glycyl) -D-alanyl-D-alanine reductase RlmK/23S rRNA aldolase: UB40_RS00600 kinase L-alanine a (2E)-enoylglutaryl- 2-methoxy-6-(all-trans gorA phosphate peroxidase EfeB: efeB cobB UB40_RS05260 acetate dehydrogenase 5 IscS subfamily UB40_RS04085 II: UB40_RS06600 Q(34) hydrolase: 3'(2'),5'- S-sulfanyl-[disordered- UbiG: ubiG thiamine- reductase: carboxybiotinyl-L-lysine succinate cis-aconitate phosphopentomutase: xanthine ATPase UB40_RS09780 -L-lysyl-D-alanine TorA: torA (guanine(2445)-N(2) UB40_RS04990 PykF: pykF amidase [acp] methyl ester 2-succinylbenzoate -octaprenyl)phenol 2-succinylbenzoate 6,7-dimethyl-8- synthase: thiE ferrochelatase: hemH (R)-lipoate [+ 2 isozymes] AdhP: adhP 2-deoxy-D-ribose α-D-glucosamine monofunctional cysteine [+ 2 isozymes] synthetase pth bisphosphate form scaffold 2-methoxy- phosphate UB40_RS01740 CcmA: ccmA methylated-DNA-- class II fructose- )-methyltransferase AmpD: ampD H + PntB H + 2-octaprenyl-6- ribityllumazine synthase: ribE asp a 1,2-diacyl- 5-phosphate deoB purine ribonucleosides degradation urea biosynthetic monofunctional trimethylamine- desulfurase: low-specificity pyruvate GluQRS: aminoacyl- nucleotidase enoylglutaryl- protein] complex 6-(all-trans- kinase: thiL protoheme bifunctional bifunctional 6-phosphate urease: ureC [protein]-cysteine S- bisphosphate RlmL: rlmKL RNase II cysteine o-succinylbenzoate- methoxyphenyl glutathione o-succinylbenzoate- 6,7-dimethyl-8- L-aspartate lipoate-- sn-glycerol peptidoglycan monofunctional biosynthetic N-oxide UB40_RS15535 an N 2 - L-threonine kinase: pyk gluQRS tRNA CysQ: cysQ [acp] methyl octaprenyl)phenol demethylmenaquinol- a butanoyl-[acp] aconitate hydratase acetaldehyde- 2-deoxy-D-ribose 5-phosphate glucosamine- UB40_RS07440 methyltransferase: aldolase: fbaA substrate with desulfurase -CoA ligase: menE hydroxylase: ubiH -CoA ligase: menE ribityllumazine synthase: ribE thiamine phosphate oxidase: nadB protein ligase: 3-phosphate deoxyribose- transglycosylase: biosynthetic peptidoglycan reductase [+ 2 isozymes] methylguanine 2445 aldolase: ltaE norophthalmate AMP N-acetyl-D- hydrolase: ester reductase: 2-octaprenyl-6- thiamine diphosphate 9 biosynthesis 2/2-methylisocitrate CoA/alcohol 6-phosphate ureA a heme(III)-bound UB40_RS01705 no poly-A tail AMP sulfur 2-iminosuccinate UB40_RS11110 beta-ketoacyl- phosphatidate cyclopropane pyruvate fermentation phosphate adenosine mtgA a CcmABCD complex peptidoglycan transglycosylase: TorA: torA in 23S rRNA glutamyl- ala muramate arfB UB40_RS01740 methoxyphenyl 4-(2'-carboxyphenyl) 2-methoxy-6-all trans- 4-(2'-carboxyphenyl) all-trans- dehydratase: acnB dehydrogenase: adhE urate deaminase: ammonium CcmE protein pyruvate predicted acceptor hydroxylase: ubiH -4-oxobutyryl-CoA 1,4-dihydroxy- [(R)- ACP synthase cytidylyltransferase: fatty acid (CFA) to ethanol I aldolase: deoxyribose- transglycosylase: mtgA a [bis(guanylyl DHAP D-glyceraldehyde dGTP queuosine at ABC octaprenyl-1,4-benzoquinol -4-oxobutyryl-CoA 6,7-dimethyl-8-(1-D-ribityl)lumazine nonaprenyl quinolinate UB40_RS12945 urea urea subunit 2-methoxy-6-all 2-naphthoate lipoyl]adenylate I: fabB UB40_RS19405 biosynthesis D-threo-isocitrate ethanol deoC phosphate adenosine a peptidoglycan with di-trans,octa-cis a [protein]-S- mtgA ala molybdopterin) acetaldehyde gly position 34 transporter a glutaryl-[acp] methyl ester 1,4-dihydroxy- bifunctional 1,4-dihydroxy- diphosphate synthase adenosylcobinamide-GDP glucosamine- a guanine in DNA trans-octaprenyl- a CDP- a [phospholipid] cis pyruvate aldolase: deoC γ -undecaprenyl methyl-L-cysteine an oxidized trimethylamine Asp Cys CsdE: csdE 2-naphthoyl- 2-naphthoyl- riboflavin synthase: lipoate-- beta-ketoacyl- deaminase: (L-alanyl- -D-glutamyl- a peptidoglycan di-trans,octa-cis cofactor of a tRNA cys a tRNA of urea 1,4-benzoquinol demethylmenaquinone NadA: nadA salvage from cobinamide I diacylglycerol -olefinic fatty acid NADP-dependent D-glyceraldehyde 6-phosphate diphosphate TorY protein beta-ketoacyl-ACP [+ 2 isozymes] CoA synthase: CoA synthase: UB40_RS02355 1,4-dihydroxy- protein ligase: ACP synthase cyclopropane acetaldehyde UB40_RS06105 L-lysyl-D-alanyl-D- a peptidoglycan di-trans,octa-cis dimer (S. aureus) -undecaprenyl chaperone]-S- an S-sulfanyl-[cysteine bifunctional methyltransferase/2- isocitrate 3-phosphate deaminase: a metal a metal synthase II: fabF UB40_RS03910 UB40_RS03910 [+ 2 isozymes] 2-naphthoate quinolinate cob(II)inamide UB40_RS11110 II: fabF CDP-diacylglycerol-- fatty acyl formate C- Pentose Phosphate Pathways acetaldehyde D-glyceraldehyde 3-phosphate alanine) pentapeptide dimer (E. faecium -undecaprenyl diphosphate sulfanyl-L-cysteine RS11115 desulfurase]-S- demethylmenaquinone (2E,6E)-farnesyl methoxy-6-polyprenyl- (2E,6E)-farnesyl a [glycine- dehydrogenase: icd UB40_RS00820 cation cation riboflavin RS18665 riboflavin beta-ketoacyl-ACP polyprenyltransferase: cob(I)yrinic acid glycerol-3-phosphate 3- phospholipid acetyltransferase: bifunctional xanthosine adenosine inosine guanosine , tetrapeptide) diphosphate sulfanyl-[disordered- methyltransferase/2- 1,4-dihydroxy-2- diphosphate 1,4-benzoquinol 1,4-dihydroxy-2- diphosphate riboflavin cleavage complex synthase I: fabB UB40_RS11565 carboxylating a,c-diamide a 3-oxohexanoyl-[acp] phosphatidyltransferase: synthase: cfa pflB 2-oxoglutarate pentose phosphate pathway acetaldehyde- bifunctional F6P form scaffold naphthoyl-CoA octaprenyl methylase UbiE: ubiE naphthoyl-CoA octaprenyl 6 methoxy-6-polyprenyl- nicotinate- H protein] N -[(R pgsA CoA/alcohol acetaldehyde- 4 γ 2069 protein] complex diphosphate 6-methoxy-3-methyl- diphosphate bifunctional riboflavin adenosyltransferase: cyclopropane formate C- an inactive an N-terminal a [protein]- an O - a DNA containing L-alanyl- -D- a mature a [glutamine DNA with adenine:7,8- a guanine Nα,Nε-diacetyl-lysyl- phosphoenol a [protein]-L- a cis-delta21-39- a [protein]- N-acetyl-L- a metal a metal a 3-oxopimeloyl-[acp] methyl ester 1,4-benzoquinol nucleotide )-lipoyl]-L-lysine 3-oxoacyl- 1-(3-sn- dehydrogenase: UTP and CTP dephosphorylation I CoA/alcohol a reduced an L-phenylalanyl- cyclic-AMP sn-glycerol 5 [cysteine desulfurase]-S- 2-all-trans-octaprenyl- [corrinoid cobO fatty acyl acetyltransferase: D-glucopyranose pyrimidine/purine pyrimidine/purine pyrimidine/purine pyrimidine/purine ribonucleoside SAM methylthymine an apurinic/ glutamyl-meso-2,6- peptidoglycan synthetase]-O dihydro-8- glutamate-O oxo-40-methyl- glutamate 5- RS14610 potassium- methylase UbiE: ubiE synthase: ispB synthase: ispB kinase/FAD synthetase: ribF demethylmenaquinol-9 diphosphorylase: arginyl-[protein] [tRNA Phe ] L-cysteine (n) in 23S rRNA D-alanyl-D-alanine 3-phosphate dADP pyruvate L-tyrosine cation cation sulfanylcysteine:[acceptor ACP phosphatidyl) phospholipid 6-phosphate adhE dehydrogenase: adhE nucleoside nucleoside nucleoside nucleoside flavodoxin in DNA 4 oxoguanine mismatch 3',5'-cyclic-AMP -methyl-ester polysaccharide + + 1,4-benzoquinol adenosyltranferase]- pflB triphosphate apyrimidinic site diaminopimeloyl- UDP-N-acetyl- (meso-DAP -(5'-adenylyl) bifunctional anaerobic glycerol- C59:1-[acp]cyclopropane semialdehyde K transporting K 3-oxoacyl-ACP protein]-cysteine 6-methoxy-3- all-trans-octaprenyl all-trans-octaprenyl nadC reductase -sn-glycerol UTP N-acetyl- 1,4-dihydroxy- 2-octaprenyl-3- superpathway of thiamine diphosphate biosynthesis I 1,4-dihydroxy- FMN cob(II)inamide a [phospholipid]synthase: cfa glucose-6- phosphorylase: phosphorylase: phosphorylase: phosphorylase: reductase D-alanine α-D-muramate containing) -L-tyrosine 23S rRNA phosphodiesterase: 3-phosphate fatty acyl biosynthesis ATPase reductase FabG: fabG sulfurtransferase: methyl-2-all- diphosphate diphosphate a [lipoyl-carrier FabG: fabG 3-phosphate acetyl-CoA acetyl-CoA penicillin- gamma- 2-naphthoate methyl-6-methoxy- 2-naphthoate superpathway of tetrahydrofolate biosynthesis NaMN fatty acid containing phosphate pyrimidine deoxyribonucleotides UB40_RS15775 UB40_RS15775 UB40_RS15775 UB40_RS15775 leucyl/ methylated-DNA-- A/G-specific (guanine(2069)-N(7) cpdA dehydrogenase: phospholipid tyrosine a metal a metal 3-oxoacyl-ACP trans-octaprenyl- 6 acetyl-CoA formate CTP synthase: bifunctional DNA- chemotaxis glutamyl- RS00805 a [cysteine UB40_RS15535 1,4-benzoquinol bifunctional riboflavin protein]-N -[(R 3-oxoacyl- phosphatidylglycerophosphatase cyclopropane dehydrogenase: dephosphorylation [+ 2 isozymes] [+ 2 isozymes] [+ 2 isozymes] [+ 2 isozymes] phenylalanyl- [protein]-cysteine S- )-methyltransferase binding 3',5'-cyclic-nucleotide pyruvate autokinase: reductase FabG: fabG 1,4-benzoquinol cys UB40_RS14285 anaerobic formamidopyrimidine UDP-N- membrane-bound bifunctional [glutamate- adenine glpC glpB glpA response synthase: cfa phosphate cation cation L-cystine RS07110 L-cystine desulfurase]-(S- 1,4-dihydroxy- hydroxylase: 1,4-dihydroxy- kinase/FAD synthetase: ribF nicotinate-nicotinamide )-lipoyl]-L-lysine ACP A: pgpA UB40_RS17260 pyrimidine nucleoside triphosphate tRNA--protein methyltransferase: RlmK/23S rRNA protein phosphodiesterase: kinase UB40_RS13815 2-octaprenyl-3- [corrinoid bifunctional pyruvate UDP ribonucleoside- glycosylase/ acetylmuramate:L- lytic murein -ammonia ligase]- glycosylase: glycerol-3- regulator protein- cyclopropane reductase: a (3R)-3-hydroxypimeloyl- sulfanyl) -[disordered- 2-naphthoate UB40_RS17905 2-naphthoate GTP nucleotide reductase an L-1- 6-phospho ribonucleosides pyrophosphohydrolase: α-D-ribose- transferase: UB40_RS09780 (guanine(2445)-N(2) 2: mrdA UB40_RS07685 PykF: pykF 2 methyl-6-methoxy- adenosyltranferase]- acetaldehyde- CTP triphosphate DNA-(apurinic alanyl-gamma-D- transglycosylase adenylyl-L-tyrosine mutY glutamate polysaccharide argC [acp] methyl ester polyprenyltransferase: cysteine polyprenyltransferase: FAD FabG: fabG phosphatidyl- fermentation degradation 1-phosphate [+ 2 isozymes] phosphate fatty acyl form scaffold 1,4-benzoquinol adenylyltransferase: cob(I)inamide CoA/alcohol D-glucono- mazG reductase- aat methylated-DNA-- or apyrimidinic glutamyl- meso- MltC: mltC phosphorylase/ )-methyltransferase pyruvate methylesterase: biosynthesis N-acetylglutamyl- a metal a metal UB40_RS11565 3-demethylubiquinol-8 desulfurase UB40_RS11565 sn-glycerol to (R)-acetoin II cytidine dCTP dCMP dehydrogenase: phospholipid RS19945 2+ 2+ 3-hydroxyacyl- protein] complex UB40_RS05275 1,5-lactone [protein]-cysteine S- RlmL: rlmKL AMP tyrosine phosphate cation cation Ca RS08155 Ca hydroxylase: GTP cob(I)yrinic acid a (3R)-3- dehydrogenase: phosphopentomutase: activating site) lyase: mutM diaminopimelate [+ 4 isozymes] [glutamate-- an N 7 - glpD kinase: pyk UB40_RS00360 synthase: cfa sulfur bis(guanylyl molybdenum acyl-[acyl- pyruvate cytidine an apurinic site α ε ACP dehydratase UB40_RS17905 cyclohydrolase nicotinate adenine a,c-diamide hydroxyhexanoyl-[acp] phosphatidylglycerol adhE 6-phosphogluconolactonase: UMP deoB protein: nrdG L-phenylalanyl-L- methyltransferase: ligase: mpl ammonia-ligase] 2069 N ,N -diacetyl- a cis-keto-C60- autokinase: bifunctional 2- acceptor cofactor) biosynthesis deaminase: cdd Phe endonuclease within DNA methylguanine DHAP FabZ: fabZ dinucleotide carrier protein] acetolactate pgl CDP nucleoside triphosphate arginyl-[protein] a tRNA UB40_RS01705 adenine lysyl-D-alanine D-ala UB40_RS00040 demethylmenaquinol-8 polyprenyl-6- demethylmenaquinol-8 I FolE: folE adenosyltransferase: biosynthesis I (plastidic) uridine D-ribose 5- adenylyltransferase: in 23S rRNA α meroacyl-[acp] 3-demethylubiquinol-8 subunit 7,8- MoO - 3-hydroxyacyl- thioesterase pathway acetaldehyde synthase pyrimidine 5'- pyrophosphohydrolase: III: nth a mature GlcNAc-1,6- a [protein]- - a [protein]- a metal a metal 3-hydroxyacyl-[acyl- ammonia- ammonia- cobO 2 D-gluconate glnE pyruvate MeOH RS19175 3+ 3+ a [cysteine desulfurase]- hydroxyphenol CsdE: csdE [acyl-carrier- nucleotidase: phosphate an active UDP-N-acetylmuramoyl- peptidoglycan anhMurNAc- dATP L-glutamate L-tyrosine Fe RS07845 Fe bifunctional dihydroneopterin molybdopterin a fatty acyl-[acyl- AlsS: alsS pyrimidine/purine mazG (n) cation cation carrier-protein] [scaffold protein- methylase/3- dependent dependent molybdopterin DHAP 6-phosphate 5'-deoxyadenosine a flavodoxin ribonucleoside a [protein]-S- γ γ bifunctional 2- demethylmenaquinone [+ 2 isozymes] 3'-triphosphate adenosylcobinamide cofactor protein] carrier protein] alcohol yjjG nucleoside met a thymine in DNA a 3'-terminal a 5'-phospho- L-alanyl- -D- (meso-DAP L-Ala- -D-Glu- phosphate dehydratase (2Fe-2S)] complex demethylubiquinol 3- an [L-cysteine NAD(+) NAD(+) NAD(P)H- multifunctional acyl- [+ 2 isozymes] dUTP diphosphatase: dut semiquinone triphosphate methyl-L-cysteine polyprenyl-6- methyltransferase/2- superpathway of pyridoxal 5'-phosphate biosynthesis and salvage dehydratase dehydrogenase (S)-2-acetolactate decarboxylating [+ 4 isozymes] CMP phosphorylase: dUTP dUMP unsaturated sugar [DNA] glutamyl-meso-2,6- containing) DAP-D-Ala a [glutamine- FabA: fabA O-methyltransferase desulfurase]-S- synthetase: synthetase: molybdenum cofactor FabA: fabA dependent CoA thioesterase reductase diaminopimeloyl- ADP synthetase]- hydroxyphenol methoxy-6-polyprenyl- adenosylcobalamin AdhP: adhP NADP(+)-dependent pyrimidine 5'- UB40_RS15775 a metal a metal ala RS01330 ala UbiG: ubiG sulfanyl-L-cysteine D-erythrose nadE nadE guanylyltransferase glycerol-3- I/protease I/ acetolactate uridine D-alanine L-tyrosine RS10135 a (2E)-enoylpimeloyl- methylase/3- 1,4-benzoquinol salvage from cobalamin [+ 2 isozymes] bifunctional phosphogluconate nucleotidase: uridine cation cation cysteine 7,8- 4-phosphate MobA: mobA phosphate lysophospholipase decarboxylase: [acp] methyl ester a [co-chaperone]- demethylubiquinol 3- methylase UbiE: ubiE NAD + acetaldehyde- dehydrogenase: gnd yjjG phosphorylase: 5-hydroxy-CTP 5-hydroxy-CMP Alcohol Degradation ubiquinol-8 a [ThiS sulfur- desulfurase dihydroneopterin adenosyl-cobinamide a (2E)-hex-2-enoyl-[acp] dehydrogenase: L1: tesA budA enoylpimeloyl- [scaffold protein- O-methyltransferase cob(I)alamin erythrose-4- CoA/alcohol D-ribulose udp UDP-N-acetyl- an N-formyl-L- 2-hydroxy-4-oxobutane- a peptidoglycan D-sedoheptulose a cis-delta19- an oxidized asp asp carrier protein] 3'-phosphate phosphate gpsA a fatty acid [+ 4 isozymes] di-trans,octa-cis- an N-terminal an L-phenylalanyl- a [DNA]-3'- + a 5'-phospho- trimethylamine hydrogen β (6R)-L-erythro-6,7- (2Fe-2S)] complex UbiG: ubiG menaquinol-8 sulfur phosphate bis(molybdenum sn-glycerol dehydrogenase: 5-phosphate α-D-glucosamine NAD a reduced c- a reduced D-glycero- -D- a PII protein L-cysteate 37-methoxy-38- nitroaromatic a metal a metal [acp] methyl (R)-acetoin ethanol L-lysyl-[protein] Phe hydroxyl [DNA] methionylaminoacyl- N-oxide peroxide ATP 1,2,4-tricarboxylate dimer (S. aureus) dihydrobiopterin 1-phosphate ATP roseoflavin a protein RS01760 SSQ1 sulfur carrier acceptor dehydrogenase: cofactor) hexanoyl-[acyl- adhE cytidine uracil glycerol and glycerophosphodiester degradation glycerol degradation V glycerol degradation II undecaprenyl phosphate [tRNA ] type cytochrome thioredoxin manno-heptose UTP cation cation ester reductase: 3-phosphate degradation II tRNA oxygen- aspartate/ methyl-C57:1-[acp]cyclopropane compoundoxygen- 5'-phosphate carboxy ala ala chaperone: ubiquinol-8 protein ThiS subunit epd molybdenum cofactor carrier-protein] ribulose- ribose-5- 1-phosphate RS10245 UB40_RS01740 cob(II)alamin glycerol-3- insensitive tyrosine/aromatic fatty acyl insensitive terminal- preQ preQ dnaK adenylyltransferase: CsdE: csdE D-erythro-7,8- 4-phospho- guanylyltransferase reductase: ethanol phosphate 3- phosphate glycerol ethanol glycerol glycerol DNA ligase: putative 4- penicillin- fructose ala ala 0 RS15095 0 bis(guanylyl molybdopterin) adenosylcobinamide- phosphate 1-O- ethanol UDP-N-acetylglucosamine-- leucyl/ peptide trimethylamine- thioredoxin- bifunctional NAD(P)H- aminotransferase: phospholipid NADPH processing preQ preQ a pimeloyl-[acp] methyl ester a [chaperone-ATP]- UB40_RS14910 [+ 2 isozymes] cob(I)yrinic acid dihydroneopterin D-erythronate MobA: mobA UB40_RS01740 epimerase: isomerase degradation I glycerol glycerol UB40_RS12425 hydroxy-4-methyl- binding bisphosphate 1 1 cofactor sulfurylation GDP acyltransferase alcohol undecaprenyl-phosphate N- phenylalanyl- deformylase: N-oxide dependent bifunctional D-glycero- uridylyltransferase/ dependent UB40_RS12270 synthase: cfa nitroreductase: bifunctional peptidase: a metal a metal [co-chaperone]- molybdenum cofactor biosynthesis a carboxy- a [ThiI sulfur- a,c-diamide bis(guanylyl acyl-CoA hydrolysis UB40_RS19885 RpiA: rpiA a glycerophosphodiester dehydrogenase: dehydrogenase: NAD- 2-oxoglutarate protein aldolase: RS18575 dihydroneopterin chorismate 4-phosphoerythronate PlsY: plsY dehydrogenase acetylglucosaminephosphotransferase: wecA tRNA--protein def reductase thiol beta-D-manno- uridylyl-removing nitroreductase aspartate/ nfsA riboflavin prc cation cation pimeloyl-ACP [scaffold protein- adenylated-[ThiS carrier protein]-S- adenosyltransferase: molybdopterin) a hexanoyl-[acp] ethanol UB40_RS10540 UB40_RS10540 dependent aldolase: 2: mrdA UB40_RS04085 cyclopropane aldolase: folB dehydrogenase: cys AdhP: adhP UDP-N-acetylglucosamine-- transferase: TorA: torA peroxidase: heptose-7-phosphate protein GlnD: glnD NfsB: tyrosine/aromatic kinase/FAD serine serine methyl ester (2Fe-2S)] complex molybdate sulfur-carrier protein] sulfanyl-L-cysteine cobO aminodeoxychorismate/ cofactor glycerol-3- a 2,3,4-saturated D-xylulose D-ribose 5- alcohol DNA ligase peptide UB40_RS10195 [+ 2 isozymes] class II fructose- fatty acyl NAD(P)H a peptide UB40_RS13940 beta-ketoacyl- bifunctional glycerol glycerophosphodiester glycerol glycerol undecaprenyl-phosphate N- aat bcp kinase/D-glycero- UB40_RS06000 aminotransferase: synthetase: RS20210 esterase BioH: bioH D-glyceraldehyde cob(II)alamin- 6-(hydroxymethyl) anthranilate synthase phosphate 1-O- fatty acyl CoA 5-phosphate phosphate dehydrogenase LigA: ligA deformylase: trimethylamine- (6R)-L-erythro-5,6,7,8- bisphosphate phospholipid nitroreductase: a metal a metal (3R)-3-hydroxy-2-oxo- ACP synthase multifunctional acyl- acetaldehyde- phosphodiesterase: dehydrogenase: dehydrogenase: acetylglucosaminephosphotransferase: wecA peroxiredoxin C: beta-D-manno- UB40_RS02070 ribF RS18520 SSQ1 predicted 3-phosphate carboxy-adenylated- [corrinoid -7,8-dihydropterin component II: cysteine acyltransferase AdhP: adhP UB40_RS02800 N-oxide a peptidoglycan tetrahydrobiopterin aldolase: fbaA synthase: cfa a reducedUB40_RS07555 cation cation thr thr AIR tyr 4 phosphooxybutanoate I: fabB CoA thioesterase Secondary Metabolite Degradation CoA/alcohol UB40_RS20160 UB40_RS01320 UB40_RS01320 L-phenylalanyl- UB40_RS15470 heptose 1-phosphate a uridylylated a cis-methoxy- a pimeloyl-[acp] chaperone ABC [ThiS sulfur- desulfurase PlsB: plsB glycerol kinase Phe reductase oxaloacetate pyruvate with D,D cross- 3-sulfopyruvate tyr RS17225 tyr 1-deoxy-D- adenosyltranferase] 2-amino-4-hydroxy-6- UB40_RS19870 transketolase: tkt bifunctional dihydroxyacetone dihydroxyacetone a tRNA adenylyltransferase PII protein D-ala nitroaromatic ATPase: dnaK transporter carrier-protein] 3-phosphoserine/ sulfur beta-ketoacyl- a 1-acyl-sn I/protease I/ dehydrogenase: GlpK: glpK [+ 2 isozymes] N-acetyl-α-D- UMP L-lysyl-[protein] TorA: torA C59-meroacyl-[acp] roseoflavin phosphomethylpyrimidine 2-iminoacetate xylulose-5- hydroxymethyldihydropteridine [+ 2 isozymes] D-glyceraldehyde transketolase: tkt acetaldehyde- [DNA] NMN link (S. aureus) compound 8-amino-7- of molybdate: sulfurtransferase: thiI phosphohydroxythreonine pyruvate acceptor ACP synthase -glycerol 3- lysophospholipase anhydromuropeptides recycling I adhE glucosaminyl- AMP formate a L-methionylaminoacyl- HldE: hldE adenine synthase ThiC: thiC synthase phosphate diphosphokinase: folK 4-amino-4- 3-phosphate CoA/alcohol an oxidized H O DHAP D-erythrose a metal a metal a [chaperone- transaminase: serC subunit phosphate L1: tesA 4-deoxy-L-threo-hex-4- acetaldehyde diphospho- tRNA 2 dinucleotide RS05495 oxononanoate an [2Fe-2S] modB modA ThiH: thiH II: fabF D-sedoheptulose D-glyceraldehyde dehydrogenase: thioredoxin cation cation ADP]-[disordered- synthase: dxs a thiocarboxylated- cob(I)alamin- 2-amino-4-hydroxy-6- deoxychorismate CsdE: csdE 1-acyl-sn-glycerol- [+ 3 isozymes] GlcNAc-1,6- enopyranuronate degradation sn-glycerol 3-phosphate ditrans,octacis an oxidized c- ADP-D-glycero-β- tyr TyrP tyr synthase: bioF cluster protein molybdenum HMP-P 4-phosphooxy- 1-deoxy-D- a 2,3,4-saturated 7-phosphate 3-phosphate adhE trimethylamine form scaffold 1-deoxy-D-xylulose [ThiS sulfur- [corrinoid hydroxymethyldihydropteridine aminodeoxychorismate a 3-oxooctanoyl-[acp] 3-phosphate anhMurNAc- 4-deoxy-L-threo-hex- acetaldehyde DHAP DHAP -undecaprenol type cytochrome D-manno-heptose ABC 2-iminoacetate L-threonine xylulose-5- [+ 2 isozymes] fatty acid γ acetaldehyde (8S)-8-amino-7-oxononanoate protein] complex molybdopterin bifunctional 5-phosphate carrier protein] adenosyltranferase] diphosphokinase: folK lyase: pabC an [L-cysteine acyltransferase: L-Ala- -D-Glu- 4-enopyranuronate dehydrogenase: anaerobic glycerol- transporter cob(I)yrinic acid (7,8-dihydropterin- 4-hydroxythreonine- phosphate transaldolase: tal DAP-D-Ala adhE 3-phosphate a metal a metal non- hydroxymethylpyrimidine desulfurase]-S- 3-oxoacyl- UB40_RS05260 bifunctional adenosylmethionine- ATP-binding 6-yl)methyl 4-phosphate synthase: 4 β cation cation lys RS06950 lys chaperonin molybdopterin thiazole synthase: a,c-diamide 4-aminobenzoate sulfanyl-L-cysteine ACP superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass dehydrogenase: 2503 core N -( -N-acetyl- a [LuxE]-S- kinase/ [+ 2 isozymes] acetate acetaldehyde- adenine an L-1- + a [protein]- a DNA methyl (2E,6E)-farnesyl a [protein]- (S)-1-pyrroline- D-sedoheptulose a [phospholipid]- a D-aspartyl- RS02525 -8-amino-7- protein adenylyltransferase: UB40_RS14920 adenosyltransferase: diphosphate dehydrogenase dxs D-erythrose 1,6-anhydro-N- glpC glpB glpA hydrogen cyanide a sulfurated NADPH NAD FAD D-glucosaminyl) an adenine in DNA MoO - (long-chain fatty Ala molecular phosphomethylpyrimidine cysteine molybdopterin biosynthesis reductase a 1,2-diacyl- F6P in 23S rRNA oligosaccharide- L-cysteine phosphotriester protoheme L-threonine 2 5-carboxylate 1,7-bisphosphate palmitoleate asp a glycyl-[tRNA ] oxononanoate ModC: modC PdxA: pdxA 4-phosphate 5-dehydro-4-deoxy- CoA/alcohol phosphatidylethanolamine [sulfur carrier] diphosphate ATP molybdopterin [tRNA ] GMP ala ala chaperone mog kinase: thiD cobO desulfurase FabG: fabG sn-glycerol D-glucopyranose 6-phosphate acetylmuramyl- glycerol-3-phosphate lipid A (E. coli -L-asparagine type I restriction- acyl)-L-cysteine bifunctional cyclopropane transaminase: bioA 2-[(2R,5Z)-2-carboxy- adenosylcob(III) dihydropteroate 3-amino-1- 1-deoxy-D- D-glucuronate acetate--CoA dehydrogenase: cofactor a metal a metal ATPase: hscA molybdopterin sulfur 3-phosphate long-chain fatty transketolase: tkt L-alanine dehydrogenase: glpD K-12 core type modification proline fatty acyl RS13670 lys RS17655 lys molybdate 4-methylthiazol-5(2H)- alamin-[corrinoid synthase: folP hydroxyacetone xylulose 5- 3-oxoacyl- ligase: acs adhE bifunctional tRNA Si-specific NAD(P)(+) methylated-DNA-- FAD:protein FMN fructose cation cation an [Fe-S cluster adenine dinucleotide HMP-PP acceptor cys phosphatidate acid activation glucose-6-phosphate transketolase: tkt amidase 5-dehydro- with D-GlcNAc) thiosulfate protoheme IX N(4)-(beta-N- system subunit M: acyl-CoA dehydrogenase/L- phospholipid D-tyrosyl- D-tyrosyl- GMP reductase: (7R,8S)-diaminononanoate ylidene]ethyl phosphate adenosyltranferase] pyridoxine 1-phosphate phosphate ACP (adenosine(37)-C2) transhydrogenase: sthA [protein]-cysteine S- transferase: bisphosphate biosynthesis bis(guanylyl subunit ATP cytidylyltransferase: isomerase: pgi AmpD: ampD 4-deoxy-D- acetyl-CoA DHAP acetyl-CoA sulfurtransferase: farnesyltransferase: acetylglucosaminyl) UB40_RS20350 molybdenum cofactor reductase: glutamate gamma- synthase: cfa tRNA(Tyr) tRNA(Tyr) UB40_RS18495 thiamine diphosphate salvage IV (yeast) cob(I)yrinic acid 7,8- reductase a long-chain D-glyceraldehyde -methyltransferase methyltransferase: UB40_RS16595 aldolase: ATP-dependent chaperone]-ATP bifunctional pyridoxamine molybdopterin) CsdE: csdE cysteine UB40_RS19405 glucuronate UB40_RS06790 Re/Si-specific NAD(P) cyoE -L-asparaginase: adenine- guanylyltransferase UB40_RS09585 semialdehyde cyclopropane deacylase: deacylase: thiamine a,c-diamide dihydropteroate pyridoxine 5'- FabG: fabG fatty acid 3-phosphate N-acetyl-β-D- L-alanyl-γ-D- TrmG/ribosomal phosphoethanolamine UB40_RS09780 UB40_RS04085 a reduced dethiobiotin molybdopterin- pyridoxal cofactor molybdopterin- desulfurase a CDP- long-chain-fatty- F6P isomerase: thiosulfate (+) transhydrogenase protoheme IX FAD:protein FMN UB40_RS17455 specific DNA- MobA: mobA dehydrogenase fatty acyl dtd dtd IMP phosphate adenosyltransferase: phosphate [+ 2 isozymes] glucosamine-1,6- glutamyl-meso-2,6- RNA large subunit transferase EptA: eptA H O c-type synthetase thiamine kinase pyridoxal synthase sulfur a (3R)-3- acid--CoA ligase: kduI subunit alpha: methylated-DNA-- transferase: PutA: putA class II fructose- 2 guanine dinucleotide S-adenosyl-L-methionine salvage I synthase: thiE cobO synthase: a [bis(guanylyl diacylglycerol methyltransferase sulfurtransferase farnesyltransferase: methyltransferase: a [LuxE]- a long-chain phospholipid cytochrome cytochrome BioD: bioD PdxY: kinase adenylyltransferase acceptor hydroxyoctanoyl-[acp] UB40_RS09560 class 1 fructose- anhydro-N-acetyl- diaminopimeloyl- UB40_RS05340 [protein]-cysteine S- UB40_RS02290 adenylyl bisphosphate an oxidized biosynthesis pdxJ molybdopterin) CDP-diacylglycerol-- β 3-deoxy-D-glycero- RlmN: trmG/rlmN GlpE: glpE UB40_RS11900 β dam L-cysteine fatty aldehyde glu a [phospholipid]-8-synthase: cfa c oxidase coenzyme A biosynthesis thiamine pdxY PdxY: subunit GTP bisphosphatase: fbp -D-muramate D-alanine methyltransferase: N-acetyl- - an N 6 -methyladenine aldolase: fbaA O c-type adaptor protein adenosylcobalamin 7,8-dihydrofolate [bis-MGD cofactor cofactor MoeB: moeB 3-hydroxyacyl- [+ 2 isozymes] 6-phosphofructokinase: pfkA 2,5-hexodiulosonate lipid A-core- molybdenum asp Ala 2 dethiobiotin phosphate thiaminase II: tenA pdxY a carboxy- glycerol-3-phosphate 3- a long-chain class II fructose- beta-N- a 1,2-diacyl- asp glucosaminylamine (2-hexylcyclopropyl) tRNA D-aspartate a tRNA gly a reduced I (prokaryotic) MobB/molybdopterin monoglutamate chaperone]- chaperone]-S- CsdE: csdE [acyl-carrier- pyrophosphoethanolamine UB40_RS01705 a [protein]-FMN- in DNA cofactor cytochrome SAH synthase: thiE phosphatidyltransferase: fatty acyl-CoA 2-dehydro- sn-glycerol an unsulfurated + octanoate pyridoxal adenylated GTP 3',8- bisphosphatase: glpX acetylhexosaminidase: 2503 thiocyanate NADH NADP H O cytochrome- c-type (R)-4'- molybdotransferase pyridoxine pyridoxamine bis-MGD sulfanyl-L-cysteine [+ 2 isozymes] protein] pgsA 3-deoxy-D- a 2-methyladenine ferroheme o AMP L-threonine D-erythrose 2 biotin synthase 4-amino-2-methyl-5- [small subunit of an [L-cysteine UB40_RS10055 γ 5'-deoxyadenosine [sulfur carrier] DHAP cytochrome MoeA: UB40_RS03775 5'-methylthioadenosine/ 5-(2-hydroxyethyl)-4-methylthiazole 5'-phosphate 5'-phosphate cyclase dehydratase 1-(3-sn- L-alanyl- -D- in 23S rRNA met 4-phosphate c oxidase, an oxidized BioB: bioB phosphopantothenatebifunctional pyrimidinemethanol molybdopterin desulfurase]-S- β-D-fructose 1,6-bisphosphate gluconate 5- a [protein]-S- S-adenosylhomocysteine MoaA: FabA: fabA phosphatidyl) fructose bisphosphate [+ 2 isozymes] glutamyl-meso- [DNA] O cbb3-type c-type molybdopterin thiamine phosphate pyridoxal NADPH repair (prokaryotes) dehydrogenase C1 Compound Utilization and Assimilation methyl-L-cysteine 2 phosphopantothenoylcysteine bifunctional hydroxyethylthiazole synthase] sulfanyl-L-cysteine moaA aldolase: UB40_RS04085 1,6-anhydro-N- diaminopimelate Cd 2+ Cd 2+ 9-mercaptodethiobiotin molybdotransferase nucleosidase: phosphopantothenate biosynthesis I a 7,8-dihydrofolate kinase pyridoxamine pyridoxamine [+ 2 isozymes] -sn-glycerol KduD: kduD RS06890 cytochrome decarboxylase/ hydroxymethylpyrimidine kinase: thiM sulfo-bis(guanylyl (8S)-3',8-cyclo-7,8- DHAP acetyl-β-muramate Zn 2+ Zn 2+ MoeA: moeA UB40_RS12305 thiamine- PdxY: 5'-phosphate 5'-phosphate 3-phosphate class II fructose- 2-dehydro-3- formaldehyde oxidation phosphopantothenate-- kinase/ molybdopterin dihydroguanosine NADPH a ring-opened 7- 3 biotin synthase [+ 2 isozymes] phosphate 4-methyl-5-(2- pdxY oxidase: pdxH oxidase: pdxH molybdopterin) a (2E)-oct-2-enoyl-[acp] bisphosphate aldolase: fbaA anhydro-N- formaldehyde oxidation formate assimilation into 5,10- formate a lipid II a peptidoglycan a [ThiI sulfur- an N -methyladenine a [ThiI sulfur- a ribonucleoside lysine within a D-tryptophanyl- a ribonucleoside a D-tyrosyl- cysteine ligase CoaBC: coaBC phosphomethylpyrimidine synthase 5'-triphosphate phosphatidylglycerophosphatase deoxy-D-gluconate VII (THF pathway) methylguanine a uracil in tRNA a peptide with a H O a RNA-DNA hybrid (R)-lipoate an aromatic a cytidine 34 (R)-4'- 3-methyl-2-oxobutanoate cofactor oxidation to CO carrier protein]- carrier protein]- cys formate 2 Trp Tyr lys BioB: bioB kinase: thiL phosphooxyethyl)thiazole triose-phosphate acetylmuramic II (glutathione-dependent) methylenetetrahydrofolate 2 ATP in DNA triphosphate GTP gcv protein H [tRNA ] diphosphate [tRNA ] ATP MoO -molybdopterin S-ribosyl-L- kinase: thiD sulfurtransferase: cyclic pyranopterin A: pgpA 2-dehydro-3- in DNA a tRNA precursor leader sequence amino acid in tRNA Ile2 phosphopantothenoyl- 2 octanoyl-[acyl- isomerase: tpiA acid kinase: S-sulfanyl- L-cysteine ribonucleotide- Zn 2+ RS03895 Zn 2+ cofactor homocysteine thiamine phosphate 3-methyl-2-oxobutanoate UB40_RS06790 monophosphate an L-1- deoxygluconokinase: formaldehyde CTP aspartate/ anaerobic biotin L-cysteine thiamine diphosphate a tetrahydrofolate PLP carrier-protein] UB40_RS02810 superpathway of β-D- formaldehyde formate formate monofunctional L-cysteine diphosphate HMP-P synthase: thiE hydroxymethyltransferase: synthase phosphatidyl- UB40_RS12975 DNA-3- ribonuclease lipoate-- tyrosine/aromatic ribonucleoside- bifunctional folate transformations III (E. coli) reductase: N-acetyl-D- glucuronosides degradation S-(hydroxymethyl) formate-- formate bifunctional DNA- biosynthetic signal IscS subfamily anaerobic D-tyrosyl- reductase: D-tyrosyl- tRNA thiamine phosphate panB a thiocarboxylated MoaC: moaC sn-glycerol D-glyceraldehyde 3-phosphate tRNA 4- methyladenine GTPase HII: rnhB protein ligase: aminotransferase: triphosphate phosphopantothenoylcysteine S-ribosylhomocysteine bifunctional NAD salvage pathway II (PNC IV cycle) UB40_RS01740 (R)-NADPHX muramate 6- a 5,10- glutathione tetrahydrofolate dehydrogenase: formamidopyrimidine peptidoglycan multifunctional peptidase I: lepB cysteine ribonucleoside- tRNA(Tyr) nrdB nrdA UB40_RS12270 tRNA(Tyr) lysidine(34) synthase: thiE [small subunit of cyclic bifunctional β KDGP thiouridine(8) glycosylase I: HflX: hflX ribonuclease UB40_RS11110 reductase: nrdD Zn 2+ RS04805 Zn 2+ decarboxylase/ lyase: luxS hydroxymethylpyrimidine 2-dehydropantoate fatty acid elongation -- saturated type I glyceraldehyde- phosphate a -D-glucuronoside synthase: gfa ligase: UB40_RS15340 glycosylase/ transglycosylase: CCA addition/ desulfurase: triphosphate deacylase: dtd deacylase: synthetase dipyrromethane a tetrahydrofolate molybdopterin pyranopterin ADP-dependent methylenetetrahydrofolate synthase UB40_RS11120 signal [+ 4 isozymes] HI: rnhA class 1b aspartate/ phosphopantothenate-- kinase/ an octanoyl-[acp] 3-phosphate N-acetylmuramic UB40_RS18210 fdxH DNA-(apurinic mtgA repair protein: UB40_RS15535 reductase: nrdD dtd TilS: tilS dATP thiamine phosphate + synthase] phosphate bifunctional S-(hydroxymethyl) 10 peptidase I: lepB ribonucleoside- cysteine ligase CoaBC: coaBC cofactor biosynthesis NAD salvage NAD NAD(P)H-hydrate acid 6- an N - ThiI: thiI UB40_RS13325 DNA-3- a [glycine-cleavage tyrosine/aromatic glutathione S-adenosyl-L- phosphomethylpyrimidine 2-dehydropantoate dehydrogenase: gap glutathione [+ 2 isozymes] or apyrimidinic [+ 2 isozymes] 6 diphosphate AI-2 an acetoacetyl-[acp] dehydratase/ bifunctional methylenetetrahydrofolate + complex H protein] N aminotransferase: L-homocysteine pathway III (to beta-ketoacyl- formyltetrahydrofolate methyladenine H Trp biosynthesis an apo-[hydroxymethylbilane methionine salvage II kinase: thiD 2-reductase: panE methionine ammonia- phosphate CO site) lyase: mutM a 2'- phosphate a nucleoside 5'- a tRNA 34 4'-phosphopantetheine molybdopterin NAD(P)H-hydrate 4-hydroxy-2- dehydrogenase/ S-(hydroxymethyl)synthase: gfa 2 di-trans,octa-cis a [ThiI sulfur- a 4-thiouracil GDP DNA -[(R)-lipoyl]-L-lysine D-tryptophan reductase: UB40_RS02070 a lysidine predicted nicotinamide riboside) synthase: metH ACP synthase etherase: murQ bifunctional a peptidoglycan glycosylase I: Tyr synthase]-L-cysteine β dependent synthase: 13-DPG D-glucopyranuronate oxoglutarate -undecaprenyl carrier protein]- a tRNA deoxyribonucleoside monophosphate nrdF nrdE an aromatic D-tyrosine a tRNA Ile2 ABC methionine -alanine epimerase: methenyltetrahydrofolate glutathione in tRNA UB40_RS19210 a leader sequence a peptide a [ThiI sulfur- a 2'- in tRNA 2+ 2+ + HMP-PP (R)-pantoate NAD(+) NAD(+) I: fabB N-acetyl-D- methylenetetrahydrofolate containing a 5'-triphosphate 2-oxo-acid Zn Zn cys glu pantetheine- synthase: NADP SAH thiamine diphosphate moaE moaD UB40_RS17870 aldolase/2- cyclohydrolase FolD: folD a [DNA]- a 5'-phospho- 2,6-diamino-4- diphosphate L-cysteine ala carrier protein]- deoxyribonucleoside transporter synthetase: nadE ammonia- diphosphatase: beta-ketoacyl- phosphoglycerate glucosamine S-(hydroxymethyl) dehydrogenase/ 4-oxo-2-pentenal 3' CCA end phosphate a [hydroxymethylbilane metH S-adenosyl-L- thiamine serine biosynthesis (S)-NADPHX dehydro-3-deoxy- a 5,10- nucleotide- [DNA] hydroxy-5-(N-methyl) S-sulfanyl- 5'-diphosphate of Zn2+ thioredoxin dependent nudC ACP synthase kinase: UB40_RS14100 6-phosphate glutathione methenyltetrahydrofolate adenylyltransferase: synthase] ES intermediate homocysteine pantoate--beta- a 7,8-dihydrofolatehydroxymethyltransferase:a 5-methyltetrahydrofolate II (Bacillus) phosphogluconate methenyltetrahydrofolate 3'-phosphate formamidopyrimidine 3-methyladenine an apurinic site L-cysteine glutamate-- 2 pathway glycine cleavage system NAD(+) molybdopterin II: fabF N-acetylglucosamine- dehydrogenase/ cyclohydrolase FolD: folD Co 2+ Co 2+ coaD met NAD + hydrolase: alanine ligase: panC UB40_RS16445 a 3-oxoacyl-[acp] bifunctional aldehydo-D-glucuronate aldolase: within DNA CorA hydroxymethylbilane synthetase: nadE HMP-PP 3-phospho-D-glycerate 6-phosphate bifunctional class III alcohol 2+ 2+ cysteine ligase: UB40_RS20465 thymidylate aminomethyltransferase a (6S)-5-formyltetrahydrofolate menaquinol-7 biosynthesis 3-oxoacyl- ADP-dependent UB40_RS19050 a 5,10- Mg Mg 3'-dephospho- synthase: hemC cytidylyl molybdenum prenylated FMNH an oxidized bifunctional nicotinate adenine dinucleotide NMN thiamine a 3-oxodecanoyl-[acp] deacetylase: nagA methylenetetrahydrofolate dehydrogenase: methenyltetrahydrofolate UB40_RS14440 methionine NAD(+) L-homocysteine 2 synthase: GcvT: gcvT ACP NAD(P)H-hydrate glucuronate CoA cofactor sulfurylation biosynthesis (R)-pantothenate thioredoxin methylenetetrahydrofolate5-formyltetrahydrofolate nicotinamide- phosphate 2,3-bisphosphoglycerate- 2,3-diphosphoglycerate- [+ 2 isozymes] [+ 2 isozymes] dehydrogenase/ UB40_RS20855 a 7,8-dihydro- trans,octacis a [protein chain an N-terminal- a 2'- an N-terminal- a [phospholipid]- a [hydroxymethylbilane adenosyltransferase: diphosphatase: thiamine diphosphate UB40_RS10330 1,4-dihydroxy- reductase dehydratase/ isomerase: bifunctional cob(II)alamin 5'-deoxyadenosine an adenosine 37 a tripeptide an N-acyl- an ADP-sugar acetyl-CoA dephospho- dehydrogenase/ cyclo-ligase: nucleotide synthase: independent dependent methenyltetrahydrofolate 8-oxoguanine -decaprenyl DL-allothreonine DMAPP (R)-β-lysine elongation factor L-methionyl-L- deoxyribonucleoside L-methionyl-L- asp oleate 2+ 2+ γ-L-glutamyl- synthase] ES intermediate cytidylyl molybdenum metK nudC 2-naphthoate 3-oxoacyl- FabG: fabG NAD(P)H-hydrate D-glucosamine uxaC methylenetetrahydrofolate ATP PRPP in tRNA L-aspartate IMP Co Co 3 methionine methylenetetrahydrofolate NAD 1,4-dihydroxy- D-glyceraldehyde S-formylglutathione in DNA phosphate 34 threonyl-[protein] deoxynucleoside alanyl-[protein] cyclopropane 2+ CorC 2+ CoA kinase: DMAPP type III pantothenate methenyltetrahydrofolateUB40_RS14130 amidase: pncC thiE ACP beta-ketoacyl- phosphoglycerate phosphoglycerate 6-phosphate pyruvate cyclohydrolase FolD: folD P]-L-lysine acetyl-CoA Mg Mg L-cysteine hydroxymethylbilane cofactor (trioxo) synthase: metH prenol thioredoxin- reductase: UB40_RS05650 phosphorylation and 2-naphthoate 3-oxoacyl- epimerase: 3-phosphate dehydrogenase/ kinase: aspartate/ fatty acyl pyrimidine 5'- coaE NMN kinase: UB40_RS20750 cyclohydrolase FolD: folD nicotinate-nicotinamide reductase mutase: gpmM mutase: gpmA D-fructuronate 10 carboxylase glutathione SAM thiamine ACP synthase UB40_RS17870 phosphoglucosamine an N - methenyltetrahydrofolate 5'-methylthioadenosine/ peptidase tyrosine/aromatic ADP nucleotidase: synthase: hemC disulfide a 5,10-methylenetetrahydrofolate a 5,10-methenyltetrahydrofolate nucleotide transhydrogenation polyprenyltransferase: FabG: fabG ACP S-formylglutathione decaprenyl-phosphate serine tRNA (adenosine(37)-N6) type I methionyl UB40_RS19000 type I methionyl phospholipid carboxyl synthase: coenzyme A an [MCD cofactor phosphate II: fabF mutase: glmM fructuronate formyltetrahydrofolate cyclohydrolase FolD: folD bifunctional DNA- cob(I)yrinic acid S-adenosylhomocysteine elongation T: pepT aspartoacylase: aminotransferase: compounds yjjG bifunctional UDP- met (R)-4'-phosphopantothenate reductase: adenylyltransferase: + UB40_RS11565 reductase 2-phospho-D-glycerate hydrolase: fghA -dimethylallyltransferase deoxynucleoside synthase: cfa transferase a [hydroxymethylbilane synthase: NAD NADPH formamidopyrimidine phosphoribosyltransferase: hydroxymethyltransferase: factor P--(R) aminopeptidase: aminopeptidase: hydrolase 2+ 2+ UB40_RS00600 chaperone]-MCD guanylyl molybdenum bifunctional demethylmenaquinol-7 3-oxoacyl- beta-ketoacyl- α reductase: formyltetrahydrofolate a 5,10- a,c-diamide nucleosidase: peptidase UB40_RS10895 UB40_RS12270 [+ 4 isozymes] Mg MgtA Mg synthase] ES intermediate sugar hydrolase/ trxB UB40_RS05275 NAD(+) FabG: fabG -D-glucosamine glycosylase/ UB40_RS14370 UB40_RS16445 MiaA: miaA -beta-lysine map kinase: map NudE: nudE cyclopropane subunit [+ 2 isozymes] 4 methionine cofactor biosynthesis methylenetetrahydrofolate thiE ACP ACP synthase phosphopyruvate UB40_RS12985 deformylase: purU formate methylenetetrahydrofolate adenosyltransferase: UB40_RS12305 T: pepT aspartate/ thiamine cysteine 5'-nucleotidase: NaMN thiamine kinase: nadK a 2,3,4-saturated a (3R)-3-hydroxyacyl- 1-phosphate N-acetylglucosamine DNA-(apurinic ligase: epmA UB40_RS17510 fatty acyl alpha: accA inosine hydroxymethylbilane adenosyltransferase: MoO - dehydrogenase/ bifunctional reductase I: fabB hydratase: eno cobO [+ 2 isozymes] a 2'- tyrosine/aromatic diphosphate desulfurase sulfur UB40_RS20195 prenyl phosphate 2 phosphate degradation II 6 glutathione synthase: hemC lipoate biosynthesis lipoate biosynthesis methenyltetrahydrofolate NADP + FabG: fabG fatty acyl-[acp] [acyl-carrier protein] bifunctional UDP-N- D-mannonate or apyrimidinic trans,octacis- N -(3-methylbut- deoxyribonucleoside α phospholipid [+ 3 isozymes] lipoate salvage I metK molybdopterin demethylmenaquinone phosphopyruvate formate an N-terminal L- a carboxylate an N-terminal L- aminotransferase: an -D-aldose 2+ 2+ salvage I acceptor subunit [+ 3 isozymes] a reduced thiamine- 3-hydroxyacyl- acetylglucosamine site) lyase: mutM decaprenylphospho- acetaldehyde 2-en-1-yl)- asp synthase: cfa malonyl-CoA Mg RS10415 Mg β UbiX family flavin cofactor tetrahydropteridine recycling and incorporation I and incorporation II cyclohydrolase FolD: folD methyltransferase/2- hydratase: eno mannonate N-acetyl-D- adenosylcobalamin gly [a protein chain a proteinogenic a dipeptide met threonyl-[protein] 5'-monophosphate met alanyl-[protein] UB40_RS02070 1-phosphate thiamine a holo-[hydroxymethylbilane CsdE: csdE 1-( -D molybdopterin- thioredoxin phosphate Re/Si-specific a (3R)-3- ACP dehydratase: Chemoautotrophic diphosphorylase/ triphosphate β-D-ribofuranose adenosine 37 AMP a [phospholipid]- demethylmenaquinol- SAM prenyltransferase: methoxy-6-polyprenyl- dehydratase: glucosamine 5-deoxy-D-ribose elongation factor amino acid oxaloacetate synthase] [+ 2 isozymes] ribofuranosyl) guanine 10 hydroxydecanoyl-[acp] UB40_RS12740 Energy Metabolism N-acetylglucosamine Detoxification dihydrosterculate (R)-lipoate octanoate an N -formyltetrahydrofolate kinase: thiL NAD(P)(+) 1,4-benzoquinol phosphoenolpyruvate glucosamine-1- a [DNA]- 5-phosphate adenine in tRNA EF-P]-N-(β-L- 6 biosynthesis I a [cytidylyl molybdenum lipoate-- nicotinamide UB40_RS13560 dinucleotide a 4a-hydroxytetrahydropteridine an octanoyl-[acp] bis(guanylyl tungstenpterin) [+ 2 isozymes] uxuA kinase: a 5'-phospho- 7,8-dihydro- lipoate-- thiamine transhydrogenase methylase UbiE: ubiE 3-hydroxyacyl- phosphate N- nucleotide- 4-oxo-2-pentenal lysyl)-L-lysine 34 Mg 2+ MgtE Mg 2+ all-trans- cofactor chaperone]- protein ligase: biosynthesis lipoyl(octanoyl) cofactor biosynthesis pyruvate kinase PykF: pykF hydrogen oxidation 2-dehydro-3- UB40_RS10060 [DNA] 8-oxoguanine thiamine prenylated FMNH protein ligase: diphosphate subunit beta: pntB [acyl-carrier- phosphoenolpyruvate acetyltransferase reactive oxygen species degradation 3'-phosphate hexaprenyl 1,4-dihydroxy- 2 protein B: mobB transferase I (aerobic) arsenate arsenate arginine phosphate cytidylyl molybdenum UB40_RS11110 UB40_RS11110 menaquinol-7 protein] synthase: ppsA pyruvate kinase: pyk GlmU: glmU deoxy-D-gluconate N-acetylglucosamine 8-oxo-(d)GTP detoxification I diphosphate 2-naphthoate [(R)- acyl carrier LipB: lipB a [lipoyl-carrier protein] NADPH detoxification detoxification dependent menaquinol-9 biosynthesis cofactor (sulfo-dioxo) molybdenum cofactor a 6,7-dihydropteridine a [lipoyl-carrier protein] dehydratase α 2-dehydro-3- kinase: nagK thiamine- lipoyl]adenylate 6 GTP N-acetyl- -D- N-acetyl-D- ε α menaquinol-6 biosynthesis base-degraded protein activation 6 N -octanoyl-L-lysine bis(tungstenpterin) H superoxide III (thioredoxin) II (glutaredoxin) acid resistance 32 an [L-cysteine lipid II (meso GMP-N- -(N- -acetyl 3-benzyl-3,6 - an N-terminal- β an N-terminal- a peptide with guanylyltransferase N -octanoyl-L-lysine FabA: fabA pyruvate 2 deoxygluconokinase: quinoxaline-2- a cytosine an L-arginyl- methyl -D-glucoside fluoride CrcB fluoride 1,4-dihydroxy- phosphate lipoate-- thiamine salvage oxygen-insensitive cofactor Ni/Fe-hydrogenase, glucosamine glucosamine a 5,10-gly a uridine 34 aryl-carrier protein desulfurase]-S- a protein diaminopimelate lysine methyl ester) bis(cysteinylglycine) L-methionyl-L- a type IV prepilin a tRNA precursor L-methionyl-L- an N-terminal NADH carbonic acid guanylyl MobA: mobA lipoyl a 2,3,4-saturated a trans-2-enoyl- UB40_RS12975 arsenate arsenate dGTP GTP carboxyl adenylate in tRNA [tRNA Arg ] 6-phosphate ATP XTP 2-naphthoate kinase: thiL demethylmenaquinol-9 protein ligase: NAD(P)H-dependent an apo acyl- lipoyl [+ 2 isozymes] pyruvate b-type cytochrome: 1-phosphate 6-phosphate superoxide arg methylenetetrahydrofolate in tRNA sulfanyl-L-cysteine containing) 5'-phosphoramidate - 6-(hydroxymethyl) cysteinyl-[protein] seryl-[protein] L-methionine demethylmenaquinol-6 formylaminopyrimidine molybdenum synthase: lipA fatty acyl-[acp] [acyl-carrier protein] arsenate arsenate RNA polyprenyltransferase: thiamine bifunctional UB40_RS11110 NADP nitroreductase NfsB: carrier proteinholo-ACP synthase: lipA molybdenum cofactor dehydrogenase complex cybH UB40_RS08930 bifunctional UDP-N- N-acetylglucosamine- dismutase [Fe]: sodB arginine -diketopiperazine inosine/ cofactor a [lipoyl-carrier a (2E)-dec-2-enoyl-[acp] KDGP reductase reductase Mg 2+ Mg 2+ UB40_RS11565 diphosphate demethylmenaquinone a [lipoyl-carrier bifunctional biosynthesis a [lipoyl-carrier guanylyltransferase dihydrolipoyllysine-residue acetylglucosamine 6-phosphate decarboxylase: 6-phospho-beta- NAD(+) carbonate xanthosine ApaG UB40_RS06000 synthase: 6 hydrogenase acyl carrier tRNA 2- monofunctional purine nucleoside type I methionyl prepilin type I methionyl type I methionyl 2+ 2+ 6 demethylmenaquinone 6 protein]-N -[(R)- 2,3,4-saturated (glutaredoxin) (glutaredoxin) tRNA uridine-5- glucosidase: diphosphatase: dehydratase: Co Co methyltransferase/2- protein]-N -[(R UB40_RS14260 protein]-N -[(R)- MobA: mobA acetyltransferase: aceF diphosphorylase/ deacetylase: nagA hydrogen peroxide 8-oxo-dGTP 8-oxo-GTP adiA thiocytidine(32) arginyltransferase: ribonuclease polynucleotide triphosphatase: aminomethylpyrimidine + large subunit: carboxymethylaminomethyl(34) protein: acpP biosynthetic phosphoramidase: membrane aminopeptidase: peptidase: aminopeptidase: aminopeptidase: methoxy-6-polyprenyl- )-lipoyl]-L-lysine methyltransferase/2- NAD a 5,6,7,8-tetrahydropteridine a holo acyl- dihydrolipoyl]-L-lysine dihydrolipoyl]-L-lysine decanoyl-[acyl- fatty acyl- glucosamine-1- [+ 2 isozymes] : arsC : arsC agmatine UB40_RS07185 D: rnd UB40_RS04535 nudC can yjjX demethylmenaquinol-6 carrier-protein] [acp]:NAD+ UB40_RS14805 bifunctional arsenite arsenite 8-oxo-dGTP synthesis enzyme MnmG: mnmG [+ 2 isozymes] synthetase peptidoglycan hinT dipeptidase: map UB40_RS07930 map adenylyltransferase map 1,4-benzoquinol methoxy-6-polyprenyl- thiaminase NAD(+) carrier protein bis(guanylyl acetyl-CoA phosphate N- D-glucosamine A(H2) 4-hydroxy-2- catalase: TtcA: ttcA transglycosylase: UB40_RS09700 PcnB: pcnB XDP Co 2+ Co 2+ methylase UbiE: ubiE 1,4-benzoquinol II: tenA kinase: reductase: fatty acid biosynthesis oxidoreductase: acetyltransferase 6-phosphate diphosphatase tRNA uridine-5- β-D-glucose reduced β- RS17500 tungstenpterin) cofactor oxaloacetate oxoglutarate UB40_RS06170 2+ 2+ menaquinol-9 methylase UbiE: ubiE nadK UB40_RS01740 UB40_RS01740 MutT: mutT carboxymethylaminomethyl(34) a quinoxaline-2- an N-terminal mtgA an N-terminal L- a nucleoside 5'- MeOH an N-terminal nicotinamide D- CO H O Ni Ni 4-amino-2-methyl-5- initiation (type II) GlmU: glmU 32 an [L-cysteine Arg N-α-acetyl lysine a cleaved type 6-phosphate 2 2 + aldolase/2- catalase/peroxidase 8-oxo-GMP a 2-thiocytosine a tRNA arginyl-[protein] 3-benzyl-3,6 - met a peptide a tRNA met met a peptide AMP menaquinol-6 NADP a decanoyl-[acyl- citrate synthase: H O hydroxyl radical synthesis GTPase MnmE: mnmE AMP carboxyl-[aryl- desulfurase]- GMP cysteinyl-[protein] monophosphate L-seryl-[protein] RNA ribonucleotide pyrimidinemethanol UDP-N-acetyl- dehydro-3-deoxy- HPI: katG 2 8-oxo-dGMP in tRNA methyl ester IV prepilin UB40_RS00890 carrier protein] lipid II (meso di-trans,octa-cis bis(cysteinyl)- 6- gly carrier protein] acetyl-CoA α-D-glucosamine L-cysteine 2+ 2+ phosphogluconate α-D-glucosamine arsenite arsenite diaminopimelate -undecaprenyl (hydroxymethyl) Co Co acetyl-CoA 34 RS14665 beta-ketoacyl- UDP-N-acetylglucosamine aldolase: a 5-carboxymethylaminomethyluridine Ni 2+ Ni 2+ Nucleoside and Nucleotide Biosynthesis carboxylase 6-phosphate O a 7,8-dihydrofolate containing) diphosphate -diketopiperazine 1-carboxyvinyltransferase: UB40_RS19050 2 in tRNA ACP synthase glucosamine- I: fabB carboxyltransferase acetyl-CoAmalate dehydrogenase: mdh murA subunit beta: malate synthase [+ 2 isozymes] 6-phosphate superpathway of pyrimidine UDP-N-acetyl-α- 2+ 2+ Tetrapyrrole Biosynthesis superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) superpathway of guanosine xanthine and xanthosine salvage superpathway of pyrimidine deoxyribonucleoside salvage CMP purine deoxyribonucleosides salvage beta-ketoacyl- UB40_RS13960 A: UB40_RS15480 deaminase: a purine base RNase III mRNA an sn-glycero-3- an N-terminal- Fe FeoB Fe ribonucleotides de novo biosynthesis phosphorylation ACP synthase (S)-malate citrate D-glucosamine- D-glyceraldehyde MoO - processing phospho-N-(acyl) diphosphate H O sulfite GSSH (S)-2- glu FMN NAD(P)H H + asp O-ureido-L- a uracil in DNA triphosphate L-methionyl-L- ADP-D-ribose formate (R)-lactate nucleotides de novo biosynthesis II malonyl-CoA pyruvate UB40_RS12945 lesion in DNA 2 GTP ATP 2 ITP 2'-deoxycytidine II: fabF enolpyruvate 3-phosphate molybdopterin substrate ethanolamine aminobutanoate homoserine valyl-[protein] D-2-hydroxyacid CTP CMP glucosamine- molybdopterin ammonium hydrogencarbonate tetrapyrrole biosynthesis gln UDP-N- cofactor dehydrogenase: inosine/ siroheme biosynthesis hydrogencarbonate ADP-ribose 2+ 2+ I (from glutamate) xanthosine (d)CMP 2'-deoxyguanosine 2'-deoxyadenosine a 3-oxododecanoyl-[acp] bifunctional aconitate 6-phosphate bifunctional DNA- thiosulfate NAD(P)H-flavin uracil-DNA formate xanthosine Fe FeoB Fe IMP cytidine acetylmuramate inorganic glutamate-- argininosuccinate inorganic type I methionyl diphosphatase: UB40_RS15725 kinase: cmk deoxynucleoside deoxynucleoside hydratase 2/2- deaminase: formamidopyrimidine ribonuclease glycerophosphodiester sulfurtransferase: reductase: fre glycosylase: dehydrogenase- triphosphatase: pyrimidine/purine deaminase: cdd CDP class II fumarate dehydrogenase: molybdenum cofactor diphosphatase: cysteine ligase: synthase: triphosphatase: aminopeptidase: nudF D-2-hydroxyacid uroporphyrinogen-III kinase: kinase: 3-oxoacyl- palmitoleate biosynthesis methylisocitrate UB40_RS00820 glycosylase/ carbamate III: rnc phosphodiesterase: UB40_RS06790 NAD(P)H-flavin ung N subunit yjjX glu glutamine- IMP nucleoside phosphorylase: dCMP hydratase: UB40_RS06625 murB guanylyltransferase UB40_RS10025 UB40_RS14440 UB40_RS11495 UB40_RS13295 map dehydrogenase: siroheme synthase: CDP nucleoside- UB40_RS17510 UB40_RS17510 ACP a malonyl-[acp] II (plants and bacteria) dehydratase: acnB DNA-(apurinic kinase: arcC UB40_RS20160 reductase: fre alpha: fdnG glutamate-- hydrolyzing dehydrogenase: UB40_RS15775 2'-deoxyuridine fumarate hydratase: UDP-N-acetyl- F6P MobA: mobA [+ 2 isozymes] thiosulfate UB40_RS13465 IDP an anion RS03925 an anion UB40_RS05475 carbamoyl- (d)CMP diphosphate deoxynucleoside deoxynucleoside reductase α or apyrimidinic [+ 2 isozymes] sulfurtransferase D-ribofuranose tRNA ligase: gltX ribonucleotide- class 1b guaB [+ 2 isozymes] ketoacyl-ACP UB40_RS01810 -D-muramate RNase III an apyrimidinic uracil pyruvate [+ 5 isozymes] phosphate xanthine kinase: cmk kinase: ndk kinase: kinase: FabG: fabG a palmitoyl-[acp] site) lyase: mutM an mRNA fragment GlpE: glpE γ-L-glutamyl-(S)- an N-terminal AMP 5-phosphate Glu diphosphate ribonucleoside- thymidine kinase: synthase III: fumarate cis-aconitate superpathway of glycolysis and the Entner-Doudoroff pathway bis(guanylyl carbamoyl processing canavaninosuccinate site in DNA phosphate diphosphate an electron- an L-glutamyl-[tRNA ] precorrin-1 UB40_RS19000 UB40_RS19000 stearoyl-[acp] UDP-N- 2-aminobutanoate FMNH NAD(P) + met L-valyl-[protein] CO synthase: reductase: diphosphate UB40_RS01060 3-oxoacyl- an N- + 2 2 XMP xanthine dCDP CTP UB40_RS07015 bifunctional aconitate acetylmuramate:L- molybdopterin) phosphate product mRNA sn-glycerol phosphate H transfer quinol carA carB nrdB nrdA reductase: dGMP dAMP ACP 9-desaturase: succinate dehydrogenase/ D-glucopyranose a [DNA]- acylethanolamine an anion RS05645 an anion uroporphyrinogen-III UDP phosphoribosyltransferase: gpt [+ 2 isozymes] thymidine [+ 2 isozymes] glyoxylate hydratase 2/2- alanyl-gamma-D- a 5'-phospho- a modified cofactor 3-phosphate glutamyl-tRNA nrdF nrdE superpathway of adenosine nucleoside- reductase UB40_RS05570 fumarate reductase 6-phosphate nucleotide- 4-oxo-2-pentenal glutathione thiosulfate C-methyltransferase: class 1b glutamine- methylisocitrate glutamyl- meso- [DNA] nucleobase reductase: hemA ribonucleotide- class 1b nucleotides de novo biosynthesis II dUMP diphosphate FabG: fabG a palmitoleoyl-[acp] iron-sulfur subunit: 3'-phosphate cobA carbamoyl asp ribonucleoside- ribonucleotide- hydrolyzing GMP an acetoacetyl-[acp] dehydratase: acnB diaminopimelate diphosphate ribonucleoside- XMP thymidine kinase: kinase: ndk UB40_RS15975 glycine glycine (S)-4-amino-5-oxopentanoate [+ 4 isozymes] phosphate diphosphate diphosphate synthase: guaA UB40_RS01060 a (3R)-3- multifunctional acyl- ligase: mpl RS10000 reductase: diphosphate thymidylate dCTP succinate dehydrogenase: a 2'- an N-terminal- an unstable betaine betaine reductase: reductase: IMP [+ 2 isozymes] hydroxydodecanoyl-[acp] CoA thioesterase a 5,10- a 2-thiouridine 34 an [HPr]- phosphoenol RNase E mRNA (2-hydroxyphenyl) D-glycero-D- D-sedoheptulose glutamate-1- precorrin-2 formate nrdB nrdA reductase: asp GMP synthase: sdhC sdhA glucose-6- UDP-N-acetyl- a peptidoglycan deoxyribonucleoside fumarate FMN NADH H + leukotriene-D4 a carboxylic ester L-methionyl- N-acetyl-L- DHAP RecA filament- aspartate nrdF nrdE nrdB nrdA dGDP dADP I/protease I/ isocitrate lyase: aceA methylenetetrahydrofolate in tRNA L-histidine pyruvate processing methyl 1-hydroxy- [DNA] manno-heptose asp 7-phosphate GTP semialdehyde 2,1- class 1b nrdF nrdE UB40_RS10330 3-hydroxyacyl- phosphate α-D-muramoyl- Carboxylate Degradation 5'-triphosphate phosphoheptose glycyl-[protein] aspartate DNA complex carbamoyltransferase lysophospholipase succinate D-threo-isocitrate substrate 6-oxocyclohex-2- 7-phosphatebifunctional D-glycero- NAD(P)H- DNA siroheme synthase: dCDP [acyl-carrier- dehydrogenase: L-alanyl-γ-D- + + aminomutase: hemL regulatory subunit: anaerobic ribonucleoside- ribonucleotide- ene-1-carboxylate isomerase: dependent anaerobic Na RS14565 Na UB40_RS05475 adenylosuccinate guanylate nucleoside- nucleoside- protein] L1: tesA NADP-dependent isocitrate UB40_RS17260 glucose-6- glutamyl-meso-2,6- tRNA uridine-5- phosphoenolpyruvate- lysozyme: beta-D-manno- NAD(P)H-flavin membrane repair UB40_RS13220 ribonucleoside- diphosphate diphosphate pyruvate decarboxylation to acetyl CoA I DNA polymerase L-aspartate carboxylesterase: UB40_RS08055 type I methionyl glycerol-3- ribonucleoside- 5-aminolevulinate nucleoside- synthase: kinase: gmk superpathway of 5-aminoimidazole diphosphate diphosphate dehydratase dehydrogenase: icd phosphate diaminopimelate pyruvate fermentation to acetate IV pyruvate fermentation superpathway of acetate carboxymethylaminomethyl(34) -protein UB40_RS18410 ribonuclease heptose-7-phosphate reductase: fre dipeptidase: aspartoacylase: protein triphosphate reductase: reductase: palmitoleate ADP-forming succinate- III subunit psi: oxidase: UB40_RS11280 D-sedoheptulose aminopeptidase: phosphate triphosphate sirohydrochlorin aspartate diphosphate UB40_RS17820 ribonucleotide biosynthesis kinase: ndk kinase: ndk FabA: fabA isomerase: pyruvate to acetate II utilization and formation synthesis enzyme MnmG: mnmG phosphotransferase: ptsP lysozyme: E: rne carboxylesterase: kinase/D-glycero- UB40_RS09700 UB40_RS10895 RecO: porphobilinogen reductase: nrdD nrdF nrdE nrdB nrdA -CoA ligase: sucC sucD a [pyruvate dehydrogenase UB40_RS10545 nadB NAD(P)H-flavin 7-phosphate map dehydrogenase: reductase: nrdD carbamoyltransferase: UTP adenylosuccinate pgi 6 dehydrogenase UB40_RS02945 beta-D-manno- a stabilizedrecO NADH:ubiquinone kinase: ndk GDP dTMP [+ 2 isozymes] E2 protein] N -lipoyl-L-lysine pyruvate tRNA uridine-5- [+ 2 isozymes] UB40_RS11280 reductase: fre isomerase: lpcA gpsA dGTP synthase: hemB siroheme synthase: pyrB dUDP synthase: dGTP dATP 6-phospho pyruvate(acetyl-transferring) pyruvate acetate [+ 10 isozymes] heptose 1-phosphate RecA filament- Na + reductase (Na(+) Na + thymidylate PRPP pyruvate acetate--CoA carboxymethylaminomethyl(34) RNase E D-glycero-D- sn-glycerol porphobilinogen UB40_RS05475 anaerobic UB40_RS11240 a (2E)-dodec- D-glucono- , homodimeric pyruvate adenylyltransferase 2-iminosuccinate succinate leukotriene-E4 an alcohol a carboxylate DNA complex -transporting) dCTP kinase: dehydrogenase ligase: acs synthesis GTPase MnmE: mnmE an [HPr protein]- N-acetyl-D- a N-acetylmuramoyl- an mRNA fragment processing 1-hydroxy-6- gly manno-heptose an N-terminal acetate 3-phosphate synthase: hemB amidophosphoribosyltransferase: purF 2-enoyl-[acp] 1,5-lactone formate C- HldE: hldE + asp N-carbamoyl- ribonucleoside- nucleoside- guanine and guanosine salvage II type: aceE dehydrogenase complex acetate kinase: N π -phospho- pyruvate glucosamine pentapeptide- salicyl alcohol D-glycero-β-D- FMNH NAD 7-phosphate met glycyl-[protein] siroheme nucleoside- class 1b ribonucleotide- UB40_RS17685 β succinyl-CoA 2-oxoglutarate complex acetyltransferase: pflB product mRNA oxocyclohex-2- [DNA] 2 porphobilinogen L-aspartate dCTP triphosphate diphosphate 5-phospho- - dodecanoyl-[acyl- phosphatidylserine and 6-phosphogluconolactonase: pyruvate dihydrolipoyllysine- UB40_RS18250 L-histidine diphosphoundecaprenol manno-heptose adenylo-succinate diphosphate ribonucleoside- diphosphate dTMP kinase: dihydrolipoyllysine- a 5-aminomethyl-2- ene-1-carboxylate an acid DauA an acid deaminase: dcd reductase: nrdD kinase: ndk D-ribosylamine carrier-protein] phosphatidylethanolamine pgl dehydrogenase formate C- residue a 7,8-dihydrofolate 1,7-bisphosphate dihydroorotase: kinase: ndk diphosphate reductase: UB40_RS06980 Metabolic Regulator residue thiouridine 34 in tRNA hydroxymethylbilane phosphoribosylamine- reductase: biosynthesis I D-gluconate complex acetyltransferase: pflB acetyltransferase: aceF acetyl phosphate acetyl-CoA pyrC adenylosuccinate reductase: nrdB nrdA guanosine Biosynthesis acetyltransferase: synthase: hemC dUTP dTDP -glycine ligase: purD UB40_RS01740 a CDP-diacylglycerol 6-phosphate F6P dihydrolipoyllysine- acetyl-CoA lyase: purB nrdF nrdE aceF thr thr class 1b inosine-5'-phosphate biosynthesis I ppGpp metabolism pyruvate residue acetyl-CoA formate a [2-oxoglutarate- UDP-N-acetyl-α-D-muramoyl-L- a 2'- N-acetyl-β-D- a UDP-sugar a PepB a peptide with RS13510 (S)-dihydroorotate nucleoside triphosphate GTP nucleoside- a dodecanoyl-[acp] 2-oxoglutarate phosphogluconate class 1 fructose- dihydrolipoyl phosphate a sulfurated 3-methylbutanoate hydrogen selenide glycerophosphoserine acibenzolar- a ribonucleoside a dipetide with an N- an isocitrate thiosulfate a mismatched serine serine preuroporphyrinogen adenine and ribonucleotide- ribonucleoside- GAR dehydrogenase acetyltransferase: phosphate SAM dehydrogenase alanyl-γ-D-glutamyl-meso-2,6- O-acetyl-L-serine deoxyribonucleoside glucosaminyl-(1 aminopeptidase an N-terminal thr pyrophosphohydrolase: AMP diphosphate dehydrogenase E1 dehydratase: bisphosphatase: fbp dehydrogenase: lpdA a [pyruvate dehydrogenase acetyltransferase: pta [sulfur carrier] [DNA] S-methyl 5'-monophosphate terminal L-aspartate dehydrogenase DNA base pair adenosine salvage V diphosphate diphosphate guanine a 3-sn-phosphatidyl- a [pyruvate dehydrogenase E2 aceF phosphate acetyltransferase: pta E2 protein] N 6 - diaminopimeloyl-D-alanyl-D-alanine 5'-triphosphate -> 4)-N-acetyl- substrate L-alanine thiosulfate DNA uroporphyrinogen- quinone- mazG AIR kinase: ndk pppGpp component: sucA UB40_RS17535 6-phosphofructokinase: complex E2 protein] N 6 -S- bifunctional UDP- bifunctional threonine reductase: reductase: phosphoribosylglycinamide L-serine class II fructose- 6 β bifunctional UDP- sulfurtransferase: mismatch III synthase: dependent dUTP beta-ketoacyl- multifunctional acyl- guanosine-5'- pfkA protein] N -dihydrolipoyl-L-lysinedihydrolipoyllysine-acetyldihydrolipoyl-L-lysine acetyltransferase: pta octanoyl-L-lysine acetate- -D-muramate sugar hydrolase/ isocitrate ammonia- thr thr anaerobic nrdB nrdA nrdF nrdE dTTP formyltransferase 2: purT bisphosphatase: acetyl phosphate D-gluconate cysteine glycerophosphodiester sugar hydrolase/ carboxylesterase: dipeptidase UB40_RS06790 repair RS13515 UB40_RS15015 dihydroorotate adenine diphosphatase: adenylate 5-(carboxyamino) xanthine ACP synthase CoA thioesterase phosphatidylserine triphosphate,3'- KDGP residue penicillin-binding -CoA DNA polymerase 5'-nucleotidase: dehydrogenase lyase, serine serine ribonucleoside- glpX degradation lipoyl synthase phosphodiesterase: 5'-nucleotidase: aminopeptidase UB40_RS11280 PepE: pepE aminopeptidase protein dehydrogenase: pyrimidine/purine dut kinase: adk imidazole ribonucleotide phosphoribosyltransferase: gpt I: fabB I/protease I/ decarboxylase: psd GTP guanosine 3'- diphosphate acetyltransferase: acetyl phosphate protein 2: mrdA ligase: acs III subunit psi: beta-N- UB40_RS20195 kinase/ thiosulfate biosynthetic: triphosphate FGAR β fructose acetate kinase: synthase: A: cysK UB40_RS20160 UB40_RS20195 PepB: pepB N: pepN MutS: mutS uroporphyrinogen-III pyrD nucleoside synthase: UB40_RS16055 adenine and adenosine salvage III hypoxanthine lysophospholipase diphosphokinase: relA diphosphate 5'- diphosphatase: gppA -D-fructose 1,6- aceF [+ 2 isozymes] UB40_RS10545 acetylhexosaminidase: [+ 4 isozymes] phosphatase: sulfurtransferase ilvA a properly dUMP reductase: nrdD beta-ketoacyl- an L-1- bisphosphate UB40_RS18250 D-gluconate lipA [+ 2 isozymes] PRPP phosphorylase: ADP dGDP phosphoribosylformylglycinamidine phosphoribosyltransferase: hpt L1: tesA triphosphate 3'- bifunctional bisphosphate acetate kinase: [+ 10 isozymes] UB40_RS10055 a ribonucleoside aceK GlpE: glpE 2-oxobutanoate matched thr thr orotate N5-CAIR ACP synthase phosphatidylethanolamine aldolase: gluconokinase: 3-methylbutanoyl- an α-D-aldose a phosphorylated SstT UB40_RS15775 thymidylate synthase: purL diphosphatase: relA 4-hydroxy-2- UB40_RS18250 acetate a [2-oxoglutarate UDP-N-acetylmuramoyl-L- acetate [+ 2 isozymes] UMP acibenzolar MeOH a proteinogenic asp sulfite DNA base pair serine serine ribonucleotide- ribonucleotide- II: fabF oxoglutarate UB40_RS04085 UB40_RS17540 an unsulfurated AMP CoA diphosphate L-selenocysteine 1-phosphate a proteinogenic amino acid isocitrate synthase: nucleoside- adenine GMP D-gluconate 5'-deoxyadenosine met dehydrogenase D-ala alanyl-γ-D-glutamyl-meso-2,6- sn-glycerol a peptide ala a peptide orotate [+ 2 isozymes] diphosphate diphosphate 5-(carboxyamino)imidazole laurate aldolase/2- DHAP acetate [sulfur carrier] ser amino acid dehydrogenase adenosine UB40_RS10330 diphosphate pyrimidine/purine FGAM class II fructose- 6-phosphate E2 protein] N 6 diaminopimeloyl-D-alanine 3-phosphate [DNA] phosphoribosyltransferase: reductase: reductase: ribonucleotide mutase: purE a 3-oxotetradecanoyl- dehydro-3-deoxy- acetyl-CoA N-acetyl-D- kinase: ndk nucleoside phosphorylase: GTP ppGpp bisphosphate -lipoyl-L-lysine GlcNAc predicted pyrE dTMP nrdB nrdA nrdB nrdA [acp] long-chain- phosphogluconate muramate adenosine asp UB40_RS15775 phosphoribosylformylglycinamidine aldolase: fbaA triose- ABC CAIR fatty-acid-- aldolase: Peptide Peptide deaminase: thymidylate class 1b class 1b dGTP [+ 2 isozymes] cyclo-ligase: purM 3-oxoacyl- phosphate transporter CoA ligase a 5-methylaminomethyl- di-trans,octa-cis 516 an N-acyl-D- orotidine 5'- kinase: ribonucleoside- ribonucleoside- nucleoside- UB40_RS19050 α all-trans- an all-trans- all-trans- a precursor of a uridine a [protein]-L- a phosphorylated (3R,5S)-3- a [protein]-L- UB40_RS06105 adenosine pyrimidine ACP isomerase: geranyl 34 UDP- -D-glucose an acyl-[acyl- of a peptide AIR FadD: fadD diphosphate Fatty Acid and Lipid Degradation selenophosphate 2-thiouridine -undecaprenyl decaprenyl 1,4-dihydroxy- polyisoprenyl decaprenyl 1,4-dihydroxy- large subunit of canavaninosuccinate glucosamine ω methylsalicylate isocitrate glu ala a protein hydroxy-1- phosphate UB40_RS17685 diphosphate diphosphate phosphoribosylaminoimidazolesuccinocarboxamide ribonucleosides salvage I reductase GTP Macromolecule Modification [+ 2 isozymes] tpiA diphosphate carrier protein] 4-hydroxybenzoate in 16S rRNA proline ( = 180) methionine synthase: UB40_RS17305 [+ 2 isozymes] kinase: ndk in tRNA phosphate diphosphate 2-naphthoate diphosphate diphosphate 2-naphthoate hydrogenase 3 16S rRNA 6-phosphate FKBP-type dehydrogenase pyrroline-5- peptide- inosine dTMP kinase: reductase: reductase: FabG: fabG diphosphokinase: relA guanosine-3',5'- putative N- bifunctional HyaD/HybD family Peptide RS05615 Peptide orotidine-5'- adenosine deaminase: cytidine oleate β-oxidation pseudouridine(516) peptidyl-prolyl cis- carboxylatepyrroline-5- methionine UB40_RS06980 nrdF nrdE nrdF nrdE lauroyl-CoA bis(diphosphate) 3'- D-glyceraldehyde acetylmannosamine- isocitrate hydrogenase phosphate UB40_RS06105 superpathway of guanine and guanosine salvage 3-oxoacyl- tRNA-uridine 2-thiolation and selenation (bacteria) fatty acid β-oxidation I (generic) phosphate 4-hydroxybenzoate argininosuccinate synthase: trans isomerase: carboxylesterase: glutamate-- carboxylate (S)-S-oxide inosine/ superpathway of pyrimidine SAICAR diphosphatase: relA 3-phosphate tRNA 2- undecaprenyl- 1,4-dihydroxy- 1,4-dihydroxy- hydrogenase 6-phosphate dehydrogenase maturation decarboxylase: dTDP ATP adenine and adenosine salvage I uridine cytidine ACP protein S-nitrosylation acyltransferase octaprenyltransferase: lyase: argH UB40_RS18855 UB40_RS17660 UB40_RS11280 cysteine ligase: reductase: reductase guanosine kinase: nucleobases salvage type I oleate selenouridine(34) phosphate glucose 2-naphthoate 2-naphthoate maturation 2-epimerase: kinase/ endopeptidase: pyrF dADP kinase: udk deaminase: reductase GDP and denitrosylation PlsX: plsX ubiA 16S rRNA [+ 11 isozymes] UB40_RS14440 UB40_RS20090 MsrA: msrAPeptide RS13995 Peptide UB40_RS00795 nucleoside- adenylosuccinate inosine cys glyceraldehyde- a (3Z)-alk-3-enoyl-CoA synthase phosphotransferase: polyprenyltransferase: polyprenyltransferase: peptidase an N-acyl-α-D-UB40_RS09815 phosphatase: UB40_RS08915 a protein-L- uracil guanosine cdd FabG: fabG pseudouridine(516) a [protein]-L- Hyp UMP diphosphate lyase: purB 3-phosphate long-chain- MnmH: mnmH UB40_RS16925 UB40_RS11565 UB40_RS11565 HycI: hycI mannosamine ω aceK a peptide methionine- inosine/ uracil anaerobic adenosine CMP a (3R)-3- a [protein]- proline ( = 0) kinase: ndk fatty-acid-- ∆ 3 ∆ 2 L-canavanine fumarate synthase RsuA: rsuA salicylate MeOH an isocitrate UMP guanosine kinase: pyrimidine/purine hydroxytetradecanoyl- cysteine desulfurase L-cysteine dehydrogenase: -cis- -trans- 3-decaprenyl-4- a 16S rRNA 6-phosphate γ-L-glutamyl- (S)-S-oxide phosphoribosyltransferase: upp nucleoside- ribonucleoside- pyrimidine/purine AICAR uridine CoA ligase a 5-methylaminomethyl- (2E)-3,7- α-D-glucopyranosyl- acyl-carrier protein an acyl phosphate a C terminal dehydrogenase kinase: UB40_RS03845 dTTP nucleoside phosphorylase: [acp] sulfur acceptor gap enoyl-CoA UMP hydroxybenzoate pseudouridine 516 D-alanine a vitamin BtuF a vitamin UMP diphosphate triphosphate nucleoside phosphorylase: pyrimidine/purine stearate biosynthesis FadD: fadD 34 DMKH DMKH2-10 a large subunit UB40_RS15775 uridine subunit CsdE: csdE isomerase: 2-selenouridine dimethylocta- diphosphoundecaprenol 2 32 amino- pyrH kinase: ndk reductase: nrdD UB40_RS15775 bifunctional 3-hydroxyacyl- II (bacteria and plants) of hydrogenase 3 [+ 2 isozymes] nucleoside kinase: udk [acyl-carrier- [+ 2 isozymes] 13-DPG [+ 2 isozymes] fadB in tRNA 2,6-diene-1-thiol acid peptide UDP IMP UMP kinase: pyrH [+ 2 isozymes] phosphoribosylaminoimidazolecarboxamide inosine/guanosine phosphorylase: a [protein] 3- UMP protein] an [L-cysteine desulfurase]- adenine formyltransferase/IMP cyclohydrolase: purH kinase: UB40_RS00795 UB40_RS15775 a palmitoyl-[acp] nitrosothio- phosphoglycerate oleoyl-CoA a vitamin BtuC a vitamin nucleoside- UDP hypoxanthine dehydratase S-sulfanyl-L-cysteine a (2E)-2-enoyl-CoA a peptidoglycan dimer with all-trans- all-trans- a ribonucleoside a [ribosomal dATP [+ 2 isozymes] beta-ketoacyl- L-alanine kinase: (1S,2R)-1- a D-aminoacyl- (-)-methyl a [lipoyl-carrier (2R,3S)-2- all-trans- a (2E,4Z)-2,4- diphosphate FAICAR inosine/guanosine FabA: fabA acyl-CoA pentapeptide stems (meso- methanethiol O-succinyl-L- 2-methylbutanoate hexaprenyl undecaprenyl 1,4-dihydroxy- (R)-lipoate 2',3'-cyclic protein L3]- RNA roseoflavin nucleoside- xanthine ACP synthase UB40_RS14100 3-hydroxyacyl- 4-hydroxybenzoate ser C-(indol-3- [tRNA] jasmonate protein]-L-lysine methylisocitrate retinyl palmitate dienoyl-CoA GTP kinase: ndk adenine xanthine kinase: UB40_RS03845 [+ 2 isozymes] dehydrogenase: diaminopimelate containing) homoserine diphosphate diphosphate 2-naphthoate phosphate bifunctional L-glutamine NADPH- bifunctional gln diphosphate kinase: ndk bifunctional phosphoribosyltransferase: gpt I: fabB acyl-CoA CoA yl)glycerol bifunctional 2',3'- 50S ribosomal phosphoribosyltransferase: apt phosphoribosyltransferase: gpt 3-phospho- UB40_RS01735 enoyl-CoA 3-phosphate aconitate dependent 2,4- diguanylate riboflavin nitrite NirC nitrite UTP UTP phosphoribosylaminoimidazolecarboxamide hypoxanthine guanine a (2E)-tetradec- beta-ketoacyl- a 2,3,4-saturated long-chain-fatty- dehydrogenase: epimerase: a 2,3,4-saturated (3R acetate- cyclic-nucleotide 2'- protein L3 hypoxanthine a [TusA sulfur-carrier protein]- D-glycerate hydratase: O-succinylhomoserine carboxylesterase: lipoate-- hydratase 2/2- carboxylesterase: ribonuclease dienoyl-CoA cyclase: kinase/FAD formyltransferase/IMP cyclohydrolase: purH phosphoribosyltransferase: hpt 2-enoyl-[acp] ACP synthase a [protein]- acyl-CoA fatty acid acid--CoA ligase: UB40_RS18100 fadB )-3-hydroxyacyl-CoA 1,6-anhydro-N- -CoA 4-hydroxybenzoate 1,4-dihydroxy- D-tyrosyl- phosphodiesterase/ N(5)-glutamine CTP synthase: phosphoribosyltransferase: hpt S-sulfanyl-L-cysteine S-nitrosoglutathione 2,3- fadB (thiol)-lyase: tryptophan UB40_RS11280 protein ligase: methylisocitrate UB40_RS11280 PH: rph reductase: UB40_RS17245 synthetase: CTP synthase: AMP II: fabF L-cysteine 2,3-bisphosphoglycerate- dehydrogenase: UB40_RS09560 acyl-CoA acetylmuramyl-L- ligase: acs octaprenyltransferase: 2-naphthoate tRNA(Tyr) 3'-nucleotidase: methyltransferase: UB40_RS14285 myristoyl-[acyl- a 3-oxooctadecanoyl- diphosphoglycerate- UB40_RS11525 synthase: UB40_RS11110 dehydratase: acnB UB40_RS07560 ribF UB40_RS14285 sulfurtransferase S-(hydroxymethyl) independent UB40_RS18100 [+ 2 isozymes] dehydrogenase: alanine amidase ubiA polyprenyltransferase: deacylase: UB40_RS17635 a [ribosomalprmB [+ 3 isozymes] lipid A MsbA lipid A CTP IMP IMP GMP carrier-protein] [acp] complex: tusC tusD dependent a 2,3,4-saturated a 2,3,4-saturated (3S trpA trpB a ribonucleoside cis-2- a (2E)-2- c-di-GMP roseoflavin glutathione phosphoglycerate (2E,9Z)- UB40_RS01735 AmpD: ampD (2S)-2- UB40_RS11565 dtd protein L3]- CTP reductase: phosphoglycerate fatty acyl CoA 3-hydroxyacyl-CoA)-3-hydroxyacyl-CoA (-)-jasmonate MeOH a [lipoyl-carrier 3'-phosphate methylaconitate palmitate a retinol a nucleoside RNA enoyl-CoA 5'-phosphate 3-oxoacyl- a [TusD sulfur-carrier protein]- octadecenoyl-CoA succinate 6 5 UB40_RS01740 dehydrogenase/ mutase: gpmM mutase: gpmA met methylbutanoyl- diphosphate 3-hexaprenyl-4- D-glyceraldehyde protein]-N -[(R N -methyl- diphosphate Carbohydrate Biosynthesis ACP S-sulfanyl-L-cysteine enoyl-CoA dehydrogenase: a peptidoglycan dimer with L-alanyl-γ-D-glutamyl- AMP class III alcohol CoA hydroxybenzoate 3-phosphate trp an uncharged )-lipoyl]-L-lysine L-glutamine ala RS02465 ala reductase 2-phospho- hydratase: fadJ pentapeptide stem (meso- meso-2,6-diaminopimeloyl- DMKH2-11 a myristoyl-[acp] dehydrogenase: a D-amino acid tRNA gluconeogenesis I FabG: fabG UB40_RS20855 D-glycerate fadB coenzyme A diaminopimelate containing) D-alanyl-D-alanine UDP-α-D- UDP-α-D-glucose acetyl-CoA C- beta-ketoacyl- phosphopyruvate (S)-3-hydroxy-(9Z) galactose biosynthesis 3-oxoacyl- a [TusE sulfur carrier S-(hydroxysulfenamide) acyltransferase Aminoacyl-tRNA Charging (S)-malate ACP synthase ACP a uridine 34 in tRNA hydratase: eno -octadecenoyl-CoA β predicted biosynthesis protein]-S-sulfanylcysteine glutathione a 2,3,4-saturated FadA: fadA a 2,3,4-saturated UDP-N-acetyl-α-D-muramoyl- sn-glycero-3-phospho- all-trans- all-trans- a 1-acyl-2- a pseudouridine 54 adenosine a [protein]-L- D-glycero- -D- a double a (2E,4E)-2,4- a protein-L- D-glucopyranose I: fabB reductase phosphopyruvate 3-hydroxyacyl-CoA di-trans,octa-cis- γ coenzyme A an apo [peptidyl- 1,4-dihydroxy- carbamoyl chitin [DNA] ABC UDP-α-D-glucose fatty acyl CoA acetyl-CoA C- 3-oxoacyl-CoA L-alanyl- -D-glutamyl-L- N-(arachidonoyl) 4-hydroxybenzoate nonaprenyl dodecaprenyl L-ornithine arachidonoyl- in tRNA 2',3'-cyclic β-isoaspartate manno-heptose stranded DNA dienoyl-CoA a protein methionine- maltose maltose tRNA charging 6-phosphate beta-ketoacyl- FabG: fabG hydratase: eno dehydrogenase: undecaprenyl phosphate carrier protein] 2-naphthoate phosphate DNA polymerase transporter UDP-glucose alpha-D-glucose tRNA 2-thiouridine(34) acyltransferase lysyl-D-alanyl-D-alanine ethanolamine diphosphate diphosphate sn-glycerol tRNA monophosphate protein-L- 1,7-bisphosphateD-glycero- DNA NADPH- Clp protease (R)-S-oxide ACP synthase a (3R)-3- fadJ CTP bifunctional 2',3'- III subunit psi: peptide- of maltose 4-epimerase phosphate-specific synthase MnmA: mnmA phosphoenol FadI: fadI 3-phosphate (pseudouridine(54) isoaspartate(D- beta-D-manno- topoisomerase dependent 2,4- ClpP: malate II: fabF hydroxyoctadecanoyl- beta-N- cyclic-nucleotide 2'- UB40_RS10545 methionine Ile His Trp Lys phosphoglucomutase: hydroxylamine pyruvate 3-oxo-(9Z)- phospho-N- holo-ACP -N(1))- aspartate) O- (ATP- dienoyl-CoA ile a tRNA his a tRNA trp a tRNA lys a tRNA GalE: galE [acp] glycerophosphodiester 4-hydroxybenzoate 1,4-dihydroxy- ornithine acetylhexosaminidase: phosphodiesterase/ heptose 1,7- UB40_RS02980 (R)-S-oxide predicted dehydrogenase: UDP-α-D-galactose pgm octadecenoyl-CoA acetylmuramoyl- synthase: methyltransferase [+ 4 isozymes] methyltransferase: hydrolyzing) reductase: a 3-oxohexadecanoyl- 34 pyruvate phospholipases phosphodiesterase: glpQ octaprenyltransferase: 2-naphthoate carbamoyltransferase: phosphatidate UB40_RS10055 3'-nucleotidase: a 2'- bisphosphate 7- [+ 2 isozymes] reductase mdh 3-hydroxyacyl- a 2-thiouridine in tRNA pentapeptide- UB40_RS14260 TrmY: trmY UB40_RS14320 subunit B: gyrB UB40_RS07560 ABC Gly Phe Arg Cys asp ser Ala phospho- [acp] kinase acetyl-CoA C- ubiA polyprenyltransferase: UB40_RS13205 cytidylyltransferase: 1 β phosphatase: arg arg gly a tRNA phe a tRNA arg a tRNA cys a tRNA tRNA asp ser a tRNA a tRNA ala malate [acyl-carrier- phosphoenolpyruvate [+ 2 isozymes] an N - [+ 2 isozymes] UB40_RS17635 deoxyribonucleoside a protein L- - a (2E)-2- a peptide MsrB: msrB transporter elongator isoleucyl-tRNA histidine- tryptophan- lysine- sugar mutase: PykF: pykF acyltransferase a 1,2-diacyl- transferase: mraY UB40_RS11565 UB40_RS19405 54 gmhB [+ 2 isozymes] a [protein]-L- glu a tRNA glu gln a tRNA Gln asn tRNA Asn thr a tRNA Thr met initiator tRNA Met met tyr a tRNA Tyr val a tRNA Val leu a tRNA Leu pro a tRNA Pro dehydrogenase: 3-oxoacyl- protein] tRNA uridine-5- acetyl-CoA methylpseudouridine 3'-AMP 5'-monophosphate isoaspartate D-glycero-β-D- of L-arginine Met synthase: ppsA a phosphatidylcholine sn-glycerol a negatively enoyl-CoA methionine tRNA synthetase: -tRNA -tRNA -tRNA UB40_RS03915 α-D- UB40_RS11085 ACP dehydratase carboxymethylaminomethyl(34) pyruvate FadI: fadI 3',5'-ADP a holo [peptidyl- 3-nonaprenyl-4- in tRNA N-acetyl-D- α-methyl ester manno-heptose ammonium 3-phosphate anandamide chitin supercoiled DNA glycine- phenylalanyl- arginine- cysteine- aspartate- serine- UB40_RS11265 alanine- ligase: hisS ligase: trpS ligase: lysS oxaloacetate glucopyranose reductase FabA: fabA synthesis enzyme MnmG: mnmG kinase: pyk acetyl-CoA C- undecaprenyl-diphospho-N- UMP carrier protein] sn-glycerol 3-phosphate hydroxybenzoate L-citrulline a CDP-1-acyl- glucosamine 1-phosphate a sugar RS05205 a sugar acyltransferase acetylmuramoyl-L-alanyl-γ-D- DMK-12 2-arachidonoyl- -tRNA tRNA synthetase: glutamate- glutamine- -tRNA -tRNA -tRNA asparagine- threonine- methionine- methionine- -tRNA isoleucine- tyrosine- valine-- -tRNA histidine- leucine- proline-- tryptophan- lysine- pyruvate 1-phosphate FabG: fabG [+ 2 isozymes] tRNA uridine-5- a 1-acyl-sn ligase: UB40_RS02400 -tRNA -tRNA ligase: ligase: ligase: -tRNA -tRNA -tRNA -tRNA ligase: -tRNA -tRNA tRNA ligase: ligase: -tRNA -tRNA tRNA ligase: -tRNA -tRNA carboxymethylaminomethyl(34) pyruvate FadA: fadA glutamyl-L-lysyl- D-alanyl-D-alanine glycerol UTP--glucose- 3-oxoacyl- a (2E)-octadec- a phosphatidylcholine -glycero-3- glyS glyQ pheS pheT ligase: gltX ligase: glnS argS cysS aspS ligase: asnS ligase: thrS ligase: metG ligase: metG serS ligase: ileS ligase: tyrS UB40_RS13165 alaS ligase: hisS ligase: leuS UB40_RS19485 ligase: trpS ligase: lysS phosphoenolpyruvate synthesis GTPase MnmE: mnmE carboxykinase phosphoenolpyruvate 1-phosphate ACP 2-enoyl-[acp] (7Z)-hexadecenoyl-CoA phosphocholine a sugar RS10810 a sugar uridylyltransferase a 5-carboxymethylaminomethyl- UDP-N-acetyl-α-D- an apo-[LYS2 L- all-trans- all-trans- all-trans- an N-terminal L- guanosine a protein an L-methionyl- (ATP): pckA synthase: ppsA reductase di-trans,octa-cis- a [protein] N-terminal- a cytidine phosphoenol (2E)-octadec- 34 coenzyme A isobutanoate 1,4-dihydroxy- A ammonium H O 3'-AMP L(or D)-O- an L-phenylalanyl- an L-glutamyl- an L-glutaminyl- an L-arginyl- an L-cysteinyl- an L-aspartyl- an L-asparaginyl- an L-threonyl- an L-methionyl- an L-seryl- an L-isoleucyl- an L-tyrosyl- an L-valyl- an L-alanyl- an L-histidyl- an L-leucyl- an L-prolyl- an L-tryptophanyl- an L-lysyl- GalU: galU FabG: fabG 2-thiouridine in tRNA acyl-CoA a 2-acyl-sn muramoyl-L-alanyl-γ-D- 2-aminoadipyl- heptaprenyl tridecaprenyl hexaprenyl alanyl-[S18 protein 2 2',3'-cyclic 32 ethylphosphate with incorrect a protein a glycyl-[tRNA Gly ] [elongator undecaprenyl phosphate 4-hydroxybenzoate 4-aminobenzoate formyl-L-methionine in tRNA phosphoserine pyruvate [tRNA Phe ] [tRNA Glu ] [tRNA Gln ] [tRNA Arg ] [tRNA Cys ] [tRNA asp ] [tRNA Asn ] [tRNA Thr ] [initiator tRNA Met ] [tRNA ser ] [tRNA Ile ] [tRNA Tyr ] [tRNA Val ] [tRNA Ala ] [tRNA His ] [tRNA Leu ] [tRNA Pro ] [tRNA Trp ] [tRNA Lys ] a (3R)-3- 2-enoyl-[acp] dehydrogenase: -glycero-3- glutamyl-L-lysyl-D-alanine carrier-protein] diphosphate diphosphate 2-naphthoate diphosphate of 30S ribosome] monophosphate tRNA (cytosine(32) disulfide bonds pyruvate Met UTP--glucose- 5-aminomethyl- a phosphatidylcholine ribosomal protein bifunctional 2',3'- acid phosphatase bifunctional 2',3'- bifunctional ATP- tRNA ] phosphoenolpyruvate reductase: Respiration phosphoserine kinase sulfite RS01110 sulfite 1-phosphate hydroxyhexadecanoyl- 2-thiouridine UB40_RS01735 phosphocholine S18-alanine N- cyclic-nucleotide 2'- /uridine(32)-2'-O)- AphA: aphA cyclic-nucleotide 2'- protein-disulfide dependent zinc UB40_RS01740 holo-ACP peptide phosphatase: PykF: pykF uridylyltransferase [acp] synthase: mnmC acyl-CoA phospho-N- acetate--CoA 4-hydroxybenzoate 1,4-dihydroxy- 4-hydroxybenzoate acetyltransferase: hydroxylamine phosphodiesterase/ methyltransferase alkaline phosphodiesterase/ isomerase/ metalloprotease phosphopyruvate UDP-N-acetyl-D- 3-hydroxyacyl- synthase: deformylase: def serB GalU: galU 2-oxoglutarate decarboxylation to succinyl-CoA dehydrogenase: phospholipase C, acetylmuramoyl- ligase: acs octaprenyltransferase: 2-naphthoate octaprenyltransferase: an N-terminal N-acetyl-rimI reductase: hcp 3'-nucleotidase: a 2'-O- TrmJ: trmJ phosphatase: 3'-nucleotidase: oxidoreductase FtsH: ftsH pyruvate hydratase: eno glucosamine biosynthesis I [acyl-carrier- a stearoyl-[acp] a 5-aminomethyl-2-thiouridine 34 in tRNA UB40_RS14260 peptide UB40_RS18100 phosphocholine- pentapeptide- ubiA polyprenyltransferase: ubiA L-alanyl-[S18 protein UB40_RS17635 methylcytidine 32 UB40_RS02285 UB40_RS17635 DsbC: dsbC serine kinase: pyk phosphopyruvate UDP-α-D-glucose protein] a [2-oxoglutarate deformylase: a protein a peptide D-glucopyranose (2E,7Z)- specific: transferase: mraY UB40_RS11565 of 30S ribosome] in tRNA pyruvate hydratase: eno dehydratase activated long- tRNA 2-thiouridine(34) dehydrogenase a holo-[LYS2 L- UB40_RS02800 3'-GMP ethanol adenosine with correct 6-phosphate 6 hexadecenoyl-CoA UB40_RS04640 isobutanoyl-CoA diphosphate 3-all trans- hydroxylamine glucose-6- FabA: fabA chain acyl synthase MnmA: mnmA E2 protein] N a phosphatidylcholine a 1,2-diacyl- 3',5'-ADP 2-aminoadipyl- AMP 3-heptaprenyl-4- disulfide bonds 2-phospho-D-glycerate Polyprenyl Biosynthesis undecaprenyl-diphospho-N UMP hexaprenyl-4- superpathway of (Kdo) -lipid A biosynthesis Cell Structure Biosynthesis phosphate hydrolase a 5-methylaminomethyl- -lipoyl-L-lysine enoyl-CoA sn-glycerol carrier-protein] hydroxybenzoate 2 Kdo transfer to lipid [+ 2 isozymes] -acetylmuramoyl-L-alanyl-γ- DMKH2-13 aminobenzoate an N-terminal L- peptidoglycan biosynthesis I (meso-diaminopimelate containing) isomerase: pgi LuxD: luxD 34 2-oxoglutarate hydratase: formate IV IV (P. putida) peptidoglycan maturation (meso-diaminopimelate containing) Amine and Polyamine Biosynthesis 2,3-bisphosphoglycerate- 2-thiouridine in tRNA D-glutamyl-L-lysyl- D-alanine methionyl-[protein] a (3R)-3- A F6P dTDP-β-L-rhamnose a (2E)-hexadec- polyisoprenoid biosynthesis (E. coli) dehydrogenase 2-oxoglutarate fadB a 1-phosphatidyl- UDP-N-acetyl- independent multifunctional acyl- geranyl a 1,2-diacyl- Amino Acid Degradation hydroxytetradecanoyl- UDP-N-acetyl- lipid IV lipid II (meso biosynthesis 2-enoyl-[acp] tRNA 2-selenouridine(34) E1 component: dehydrogenase (S)-3-hydroxy-(7Z) 1D-myo-inositol α A phosphoglycerate CoA thioesterase diphosphate sn-glycerol [acp] α-D-glucosamine -D-glucosamine CMP-Kdo putrescine glutamine-- synthase MnmH: mnmH sucA E1 component: 4,5-bisphosphate an N-terminal L- 4-hydroxy- an oxidized (P. putida) diaminopimelate containing) cadaverine α palmitoyl-[acyl- I/protease I/ biosynthesis -hexadecenoyl-CoA lysine within a Chi-site containing a RecA DNA a 2,3,4-saturated sn-glycero-3- guanosine 2251 a uridine 32 UDP-N-acetylglucosamine biosynthesis I histamine mutase: gpmM fructose-6- -D-glucopyranose IPP L-arginine degradation V coenzyme A ammonium NAD + H O a ribonucleoside NaMN sucA L-threonine degradation I cob(II)inamide an octanoyl-[acp] double stranded recombination 1,2-diacyl-sn- VibB 2 alanyl-[S5 protein 3'-GMP 4-methyl-2- nitroaromatic 1-carboxyvinyltransferase: monofunctional biosynthesis 1-phosphate carrier-protein] lysophospholipase a 5-methylaminomethyl-2-(S- dihydrolipoyl 3-hydroxyacyl-CoA (arginine deiminase pathway) L-arginine degradation L-proline degradation I L-threonine degradation IV L-glutamine ATP gcv protein H phosphoethanolamine 3'-phosphate in 23S rRNA in tRNA a protein a protein acyl-ACP--UDP-N- lipid IV(A) 3- biosynthesis phosphate IPP 34 L-methionine DNA with a blunt end and repair protein glycerol 3-phosphate CTP of 30S ribosome] 23S rRNA tRNA (cytosine(32) bifunctional UDP- oxoglutarate compound murA biosynthetic 3-phospho-D-glycerate glucose-1-phosphate reductase: L1: tesA isopentenyl- geranyl)thiouridine in tRNA dehydrogenase:a [2-oxoglutarate a [2-oxoglutarate dehydrogenase: II (AST pathway) degradation I ribosomal protein bifunctional 2',3'- bifunctional 2',3'- putative 4- HslU--HslV acetylglucosamine O- deoxy-D-manno- arg transaminase thymidylyltransferase (2E,6E)- lpdA degradation I (to (guanosine(2251) /uridine(32)-2'-O)- sugar hydrolase/ cyclic-nucleotide 2'- NAD(P)H metalloprotease α peptidoglycan lys UB40_RS01740 diphosphate tRNA 2-selenouridine(34) dehydrogenase dehydrogenase fadJ S5-alanine N- cyclic-nucleotide 2'- hydroxy-4-methyl- peptidase acyltransferase: lpxA UDP-N-acetyl- - octulosonic acid arginine his phosphoglycerate (isomerizing) stearate farnesyl arg thr pro thr L-homocysteine) lipoyl(octanoyl) glycerophosphodiester holo-ACP nitrite reductase -2'-O)- methyltransferase 5'-nucleotidase: nitroreductase: PmbA: pmbA transglycosylase: RfbA: rfbA Delta- 6 6 3-oxo-(7Z)- arg gln phosphatidate acetyltransferase: phosphodiesterase/ phosphodiesterase/ 2-oxoglutarate ATPase: D-glucosamine- transferase: decarboxylase: lysine kinase: : glmS diphosphate synthase MnmH: mnmH E2 protein] N E2 protein] N -S- cob(I)yrinic acid transferase exodeoxyribonuclease phosphodiesterase: synthase: small subunit UB40_RS07555 [+ 2 isozymes] mtgA histidine glucose-1-phosphate a palmitoyl-[acp] isomerase: idi hexadecenoyl-CoA threonine ammonia- bifunctional imidazole glycerol cytidylyltransferase: an N-terminal N-acetyl-rimJ 3'-nucleotidase: methyltransferase a 2'-O- TrmJ: trmJ UB40_RS20195 3'-nucleotidase: aldolase: a reduced hslV hslU UDP-3-O-[(3R)-3- enolpyruvate UB40_RS11735 adiA decarboxylase: UB40_RS14100 D-glucosamine long-chain- synthase: ispA a 5-methylaminomethyl-2-(Se- -dihydrolipoyl- succinyldihydrolipoyl- arginine arginine N- met a,c-diamide LipB: lipB V: recC recB recD UB40_RS20160 UB40_RS14260 NirD: nirD decarboxylase: lyase, biosynthetic: ilvA proline UB40_RS19405 RlmB: rlmB 32 [+ 3 isozymes] UB40_RS17635 hydroxymyristoyl]-N- a nascent peptidoglycan cadA thymidylyltransferase geranyl 34 L-lysine L-lysine acetyl-CoA C- succinyltransferase: phosphate synthase adenosyltransferase: L-alanyl-[S5 protein UB40_RS17635 2-O- methyluridine UB40_RS10195 nitroaromatic a peptide a peptide UDP-N- agmatine 6-phosphate fatty-acid-- phospho)selenouridine in tRNA tRNA processing deiminase: (2Z)-2-aminobut-2-enoate low specificity methionine [+ 2 isozymes] nitrite reductase: β-D- α with (L-alanyl-γ-D-glutamyl- cadaverine UB40_RS17720 RfbA: rfbA activated long- DMAPP diphosphate dehydrogenase/L- subunit HisH: hisH of 30S ribosome] a ribonucleoside 2251 in tRNA compound acetyl- -D-glucosamine D-ribulose 5-phosphate α-Kdo-(2->6) 13-DPG CoA ligase acyltransferase arcA N 2 -succinyl-astA L-threonine adenosyltransferase: cobO a [glycine-cleavage methylguanosine ribosylnicotinate pyruvate UDP-3-O-acyl-N- acetylmuramate meso-2,6-diaminopimeloyl-D- histamine phosphoglucosamine dTDP-α-D-glucose chain acyl tRNA 2-selenouridine(34) glutamate gamma- a double stranded DNA a holo-[VibB aryl- nirB nirD guanosine -lipid IV agmatinase: FadD: fadD FadI: fadI L-arginine aldolase: metK [+ 7 isozymes] acyl-carrier protein complex H protein] a CDP-2,3,4-saturated- 3',5'-ADP in 23S rRNA dehydrogenase: A (2E,6E)- synthase MnmH: mnmH a polycistronic semialdehyde with a RecA protein acetylglucosamine D-arabinose alanyl-D-alanine) pentapeptide mutase: glmM hydrolase glu 6 sn-glycerol carrier protein] murB (P. putida) speB type I dTDP-glucose 4,6- [+ 2 isozymes] farnesyl acetyl-CoA C- L-citrulline UB40_RS04990 SAM adenosylcobinamide N -octanoyl-L-lysine diacylglycerol ethanolamine deacetylase: lpxC 5-phosphate α LuxD: luxD tRNA precursor N-succinylarginine dehydrogenase triphosphate loaded 3' overhang 3-phosphate ala UDP-N-acetyl- lipid IV(A) 3- glyceraldehyde- -D-glucosamine dehydratase: rfbB diphosphate a 5-methylaminomethyl-2- 2-oxoglutarate acyltransferase low-specificity nitrite UDP-3-O-(3- isomerase: penicillin-binding penicillin-binding 34 dihydrolase: astB PutA: putA α-D-muramate deoxy-D-manno- putrescine triose- 3-phosphate 1-phosphate dTDP-glucose 4,6- multifunctional acyl- stearoyl-CoA synthase: ispA selenouridine in tRNA dehydrogenase FadA: fadA 2-iminobutanoate (S)-1-pyrroline- L-threonine hydroxymyristoyl) UB40_RS08160 protein 2: mrdA protein 2: mrdA phosphate dehydrogenase: dehydratase: rffG CoA thioesterase ribonuclease E1 component: ornithine N 2 -succinyl- 5-carboxylate α octulosonic acid bifunctional UDP-N- aldolase: ltaE - -D-glucosamine aldehydo-D-arabinose [+ 2 isozymes] [+ 2 isozymes] a mature peptidoglycan with isomerase: gap I/protease I/ geranyl E: rne sucA (5Z)-tetradecenoyl-CoA carbamoyltransferase: L-ornithine UDP-N- glu transferase: acetylglucosamine dTDP-4-dehydro-6- (Kdo) -lipid A a [sulfatase]- an N-terminal a guanosine 18 uridine 746 an [amino-group carrier a cytidine 34 RNase II hydrogen RNase G UDP-3-O-(3- (L-alanyl-γ-D-glutamyl-meso- 2 diphosphate ribonuclease UB40_RS13205 coenzyme A an apo-[aryl- an L-arginyl- 1,4-dihydroxy- pimeloyl-CoA A(H2) ethanol 5-phosphate acetylmuramate- UB40_RS11735 tpiA D-glyceraldehyde diphosphorylase/ deoxy-α-D-glucopyranose lysophospholipase biosynthesis I (E. coli) 2-oxoglutarate SAH L-cysteine SAM 3-sulfino-L- glycerophosphoglycerol GGPP ala γ-L-glutamyl-(S)- gly protein]-C-terminal-γ- degradation peroxide degradation a protein repressor LexA hydroxymyristoyl) a nascent peptidoglycan a nascent peptidoglycan 2,6-diaminopimeloyl-D-alanyl- DHAP a tRNA precursor ribonuclease E: rne acyl-CoA carrier protein] [tRNA Arg ] 2-naphthoate in tRNA in 23S rRNA in tRNA -L-alanine glutamate α-Kdo-(2->4)-α- 3-phosphate glucosamine-1- L1: tesA (2E,6E)- dehydrogenase acetaldehyde gly alanyl-[protein] 2-aminobutanoate tRNA bifunctional tRNA (L-glutamyl)-L-glutamate tRNA (cytidine(34) substrate mRNA catalase/ substrate mRNA glucosamine N- with (L-alanyl-γ-D-glutamyl- with D,D cross-links (meso- D-alanine) pentapeptide dTDP-4- α-Kdo-(2->4)-α-Kdo- with a 5' extension R: rnr dehydrogenase: ribonuclease ribonuclease ligase: murC racemase: Kdo-(2->6)-lipid phosphate N- farnesyl complex carbamoyl 2-oxobutanoate 2 L-glutamate-5- (guanosine(18)-2'-O) pseudouridine(32) -2'-O)- peroxidase acyltransferase: meso-2,6-diaminopimeloyl- diaminopimelate containing) dehydrorhamnose palmitate (2->6)-lipid IV (E. coli) and a long 3' trailer [+ 2 isozymes] UB40_RS18100 L-ornithine N -succinyl- bifunctional S-adenosyl-L- acetylglutamate R: rnr catalase/ G: rng endopeptidase repressor UB40_RS15315 IV (P. putida) acetyltransferase lauroylA diphosphate phosphate semialdehyde anaerobic holo-ACP glycerophosphodiester 1,4-dihydroxy- -methyltransferase synthase/23S rRNA methyltransferase: HPI: katG lpxD D-arabinofuranose A D-alanine) tetrapeptide 3,5-epimerase: rfbC dihydrolipoyllysine- L-glutamate 5- homocysteine 8-amino-7- glutathione kinase: argB exoribonuclease La: lon LexA: lexA UDP-N-acetyl- synthase: ispA a tRNA precursor with acyl-CoA 2-ketobutyrate acetaldehyde- arginyltransferase: phosphodiesterase: glpQ peroxidase ribonuclease UDP-2-N,3-O-bis[(3R)- GlmU: glmU long-chain- α α acyltransferase: lpxL residue carbamate semialdehyde hydrolase: sulfatase synthase: 2-naphthoate oxononanoate TrmH: trmH pseudouridine(746) UB40_RS11635 catalase: 5-phosphate α-D-muramoyl- D-glt dTDP-4- -Kdo-(2->4)- -Kdo-(2-> a 5' extension and dehydrogenase: formate-lyase: pflB bifunctional CoA/alcohol UB40_RS07185 [+ 2 isozymes] synthase: a 2'-O- an [amino-group carrier a 2'-O- II: UB40_RS06600 HPI: katG E: rne fructose N-acetyl-α-D- fatty-acid-- (2E,6E)-farnesyl succinyltransferase: kinase: arcC UB40_RS20465 maturase: UB40_RS14260 polyprenyltransferase: synthase: bioF 18 synthase RluA: rluA 34 a nucleoside 5'- UB40_RS06170 cleaved 3-hydroxytetradecanoyl]- dehydrorhamnose 6)-(lauroyl)-lipid IV (E. coli) succinylglutamate- proline dehydrogenase: UB40_RS00600 methylguanosine 746 protein]-C-terminal- methylcytidine a peptide 3-deoxy-8- L-alanine a mature peptidoglycan A a short 3' extension UB40_RS01735 a pseudouridine an mRNA fragment α bisphosphate glucosamine CoA ligase diphosphate odhB UB40_RS19075 UB40_RS11565 γ monophosphate repressor LexA -D-glucosamine phosphooctulonate with D,D cross-links (meso- 3,5-epimerase: rfbC lauroyl-Kdo(2)-lipid IV(A) ribonuclease ribonuclease glutamine- propanoyl-CoA semialdehyde dehydrogenase/L- adhE glycine cleavage [+ 2 isozymes] in tRNA -(5-phospho-L- in tRNA acetaldehyde aldolase: 1-phosphate FadD: fadD ribonuclease (2E,5Z)- L-homocysteine an N-terminal L- in 23S rRNA UDP-2,3- synthase: kdsA UDP-N- a nascent peptidoglycan a nascent peptidoglycan with a nascent peptidoglycan a mature peptidoglycan diaminopimelate containing) dTDP-4-dehydro- myristoyltransferase: R: rnr P protein hydrolyzing dehydrogenase: glutamate gamma- 3',5'-ADP a holo-[aryl- glycerol sn-glycerol (8S)-8-amino-7- glutamyl)-L-glutamate A H O γ γ γ D: rnd tetradecenoyl-CoA a [glycine-cleavage a [sulfatase]-3- Arg arginiyl-3-sulfino- 2 diacylglucosamine with L,D cross links (meso- (L-alanyl- -D-glutamyl-meso- with (L-alanyl- -D-glutamyl- with (L-alanyl- -D-glutamyl- UB40_RS04085 bifunctional UDP-N- β-L-rhamnose [+ 2 isozymes] lpxM isoprenyl octaprenyl [+ 2 isozymes] carbamoyl- phosphate astD semialdehyde acetyl-CoA 5'-deoxyadenosine carrier protein] a tRNA 3-phosphate coenzyme A acetylmuramoyl- component: complex H protein] N 6 met demethylmenaquinol-4 oxononanoate diaminopimelate containing) 2,6-diaminopimelate) tripeptide meso-2,6-diaminopimeloyl- meso-2,6-diaminopimeloyl- 2 glycine cleavage system oxo-L-alanine L-alanyl-[protein] diphosphatase: lpxH KDO-8P class II fructose- acetylglucosamine α α transferase: diphosphate ∆ 3 2 phosphate propionyltransferase: pta N - dehydrogenase ophthalmate L-alanine--D- dTDP-4- palmitoyl-CoA -D-Kdo-(2->4)- -D- ribonuclease rnpA -cis-∆ -trans- enoyl-CoA -[(R)-lipoyl]-L-lysine glycine) tetrapeptide D-alanine) tetrapeptide bisphosphate diphosphorylase/ UB40_RS19400 synthase: ispB NADH repair (prokaryotes) synthase: succinylglutamate PutA: putA aminomethyltransferase lipid X glutamate ligase: dehydrorhamnose Kdo-(2->6)-lipid A (E. coli) PH: rph a tRNA precursor with enoyl-CoA hydratase: aldolase: fbaA glucosamine-1- reductase: rfbD carA carB propanoyl phosphate succinylglutamate glycine cleavage system GcvT: gcvT UB40_RS08000 di-trans,octa-cis all-trans- polyribonucleotide a short 3' extension isomerase: fadB lipid-A- a mature peptidoglycan a mature peptidoglycan with phosphate N- a tRNA precursor NADH desuccinylase: glu aminomethyltransferase aminomethyl- a mature peptidoglycan (meso an N-terminal a peptidoglycan N-acetyl-muramoyl-(L- a peptidoglycan a cytidine 2498 a uridine 32 a guanine 527 a 5,6- (R)-4-hydroxy- dTDP-4- nucleotidyltransferase: pnp fadB L-glutamate coenzyme A AsbD acyl- an L-arginyl- maltoheptaose 20 MeOH an unfolded γ acetyltransferase -undecaprenyl octaprenyl carbamate GcvT: gcvT transferring -diaminopimelate containing) 3-sulfo-L- dimer (E. faeciums) alanyl-γ-D-glutamyl-L- dimer (generic) dihydrouracil mutated tRNA 4-methyl-2- Ins(1,4,5)P disaccharide UDP-N-acetyl- with L,D cross-links (meso- (L-alanyl- -D-glutamyl-meso- a mature peptidoglycan dehydrorhamnose with a 5' extension acetate kinase: UB40_RS02425 Arg in 23S rRNA in tRNA in 16S rRNA ATP 3 α-Kdo meso- diphosphate diphosphate (S)-3-hydroxy-(5Z) degradation II carrier protein [tRNA ] in tRNA oxoglutarate catalase/ protein synthase: lpxB α-D-muramoyl-L- diaminopimelate containing) 2,6-diaminopimelate) tripeptide with (L-alanyl-γ-D-glutamyl- GlmU: glmU reductase: rfbD UB40_RS18250 dihydrolipoyl glycine alanyl-[protein] lysyl-D-alanyl-D-alanine) 23S rRNA bifunctional tRNA 16S rRNA tRNA ribonuclease putative 4- inosine/ diaminopimelate β-D-fructose 1,6- undecaprenyl- ribonuclease ribonuclease (3E,5Z)-tetradeca- -tetradecenoyl-CoA peroxidase lipid A disaccharide alanyl-D-glutamate meso-2,6-diaminopimeloyl- UDP-N-acetyl- L-threonine glu dehydrogenase: dehydrogenase: murein penicillin-binding alpha-glucosidase: murein (cytidine(2498)-2'-O) pseudouridine(32) (guanine(527)-N(7) dihydrouridine(20/ R: rnr hydroxy-4-methyl- class I adenylate xanthosine chaperonin 3-deoxy-manno- lipid IV biosynthesis (P. putida) bisphosphate α dTDP-β-L-rhamnose diphosphate ribonuclease PH: rph D: rnd 3,5-dienoyl-CoA 3-hydroxyacyl-CoA degradation II propanoate glu gcvP holo-ACP -methyltransferase synthase/23S rRNA )-methyltransferase HPI: katG (E. coli) A glycine) tetrapeptide -D-glucosamine lpdA penicillin-binding cyclase: triphosphatase: GroEL: groL octulosonate phosphatase: P protein acyl-CoA dehydrogenase: aspartate/ a [glycine-cleavage transglycosylase: sltY arginyltransferase: protein 2: mrdA UB40_RS04470 transglycosylase 20a) synthase exoribonuclease 2-oxoglutarate UDP-N- L-serine degradation a [glycine-cleavage synthase: RlmM: rlmM pseudouridine(746) 7 RsmG: rsmG catalase: tetraacyldisaccharide class 1 fructose- 6 [+ 5 isozymes] [+ 2 isozymes] protein 2: mrdA alpha- A: mltA a 2-O- an N - DusA: dusA II: UB40_RS06600 aldolase: UB40_RS15025 yjjX cytidylyltransferase: a (3R)-3- UB40_RS13330 component: (R)-NADHX thioesterase fadJ CO tyrosine/aromatic 6 complex H protein] N - UB40_RS07185 acetylmuramoyl- bisphosphatase: fbp 2 complex H protein] N UB40_RS14260 2498 synthase RluA: rluA 527 20 a nucleoside 5'- UB40_RS06170 4'-kinase: lpxK di-trans,octa-cis bifunctional thr [+ 2 isozymes] glucosidase: ygjK [+ 5 isozymes] methylcytidine 32 methylguanine a uracil in tRNA UB40_RS10195 cyclic-AMP Ins(1,4)P a protein kdsB hydroxydecanoyl- UDP-N-acetyl- rnpA II: tesB 3-oxo-(5Z)- aminotransferase: aminomethyldihydrolipoyl- a pseudouridine 2 L-alanyl-D- class II fructose- L-threonine -dihydrolipoyl-L-lysine monophosphate formaldehyde [acp] α-D-glucosamine Kdo transfer to lipid -undecaprenyl queuosine ADP-dependent tetradecenoyl-CoA ser UB40_RS12270 L-lysine a mature peptidoglycan a mature peptidoglycan strand a peptidoglycan tetramer in 23S rRNA in tRNA in 16S rRNA pyruvate lipid IV (E. coli) CMP-Kdo glutamate--2, 6- bisphosphatase: acyl-CoA dehydrogenase: a holo-[AsbD acyl- an N-terminal L- A IV II (Haemophilus) phosphate biosynthesis I (de novo) NAD(P)H-hydrate L-aspartate L-asparagine with (L-alanyl-γ-D-glutamyl- (non-reducing terminus) 3',5'-ADP with a D,D cross-link D-ala N-acetyl-muramoyl-(L- GlcNAc-1,6- diaminopimelate A thioesterase: acetyl-CoA C- yiaY L-serine aspartate/ a tRNA Arg arginiyl-3-sulfo- D-glucopyranose maltohexaose a lipid II D-ala acyl-ACP--UDP-N- glpX dehydratase/ degradation I degradation I meso-2,6-diaminopimeloyl- carrier protein] (Enterococcus faecium) alanyl-γ-D-glutamyl- D-ala anhydro-MurNAc- ligase: murE CMP-Kdo lipid IV (E. coli) PRPP biosynthesis UB40_RS12755 acyltransferase ammonia-lyase: tyrosine/aromatic L-alanyl-[protein] lipid IV(A) 3- acetylglucosamine O- A preQ NAD(P)H-hydrate L-threonine 3- D-alanine) tetrapeptide L-lysyl-D-alanine) pentapeptide F6P 5-(methoxycarbonylmethoxy) an uncharged tRNA 0 (3E,5Z)- FadA: fadA 2-aminoprop-UB40_RS01790 aminotransferase: L-arginine degradation III deoxy-D-manno- D-alanine--D- acyltransferase: lpxA NADPH-dependent 7- epimerase: dehydrogenase: glycine cleavage system L-glutamine UDP-N-acetyl- D-ribose 5- uridine biosynthesis tetradecadienoate acetyl-CoA C- asp asn 2-enoate UB40_RS02070 (arginine decarboxylase/ octulosonic acid alanine ligase: lipid IV(A) 3- glucose-6- cyano-7-deazaguanine UB40_RS17870 tdh aminomethyltransferase degradation II α-D-muramoyl- phosphate (S)-NADHX L-2-amino-3- aspartate/ asparaginase: asp UDP-N-acetyl- decaprenyl-diphospho-N- XXLG xyloglucan a peptide with 1402 966 α-Kdo8N- UDP-3-O-[(3R)-3- ribose-phosphate reductase QueF: queF acyltransferase agmatinase pathway) a single [EntB aryl- O-succinyl-L- maltopentaose a cytidine a [release factor]- a guanine a [protein] (L-serine/L- a ribonucleoside succinate transferase: UB40_RS04940 L-alanyl-γ-D- deoxy-D-manno- phosphate oxobutanoate tyrosine/aromatic ansA GcvT: gcvT α-D-glucosamine acetylmuramoyl-pentapeptide coenzyme A oligosaccharide an N-terminal (2->6)-lipid IV an oligopeptide histidinol glyoxal hydroxydecanoyl]- pyrophosphokinase: SAM preQ FadI: fadI stranded DNA carrier protein] homoserine in 16S rRNA L-glutamine in 16S rRNA threonine) phosphate triphosphate A semialdehyde UB40_RS11735 octulosonic acid isomerase: pgi Secondary Metabolite Biosynthesis 1 3-deoxy-D-manno- glutamyl-meso-2,6- α prephenate bifunctional aminotransferase: L-asparaginase aspartate arg gln Xaa-L-proline 16S rRNA peptide chain 16S rRNA anaerobic NAD-dependent histidinol isoprenoid D-alanyl-D-alanine N-acetyl- -D- transferase: UB40_RS20255 (3Z)-dodec- glycine C- protein oligopeptidase diaminopimelate D-glucopyranose ADP-dependent UB40_RS12270 2: ansB ammonia- arginine glutamate undecaprenyldiphospho- (cytidine(1402)-2'-O) release factor (guanine(966)-N(2) ribonucleoside- octulosonic succinate- dehydrogenase: biosynthesis α-Kdo-(2->6)- glucosamine UB40_RS11735 PRPP 3-enoyl-CoA acetyltransferase: 2-iminopropanoate exodeoxyribonuclease beta- alpha-glucosidase: phosphatase A: prlC 6-phosphate methylerythritol phosphate pathway I methylerythritol phosphate pathway II NAD(P)H-hydrate asp lyase: aspA decarboxylase: synthase muramoylpentapeptide beta-N- holo-ACP O-succinylhomoserine leucyl -methyltransferase: N(5)-glutamine )-methyltransferase triphosphate acid kinase: semialdehyde hisD glyoxalase lipid IV (E. coli) UDP-3-O-acyl-N- autoinducer AI-2 preQ biosynthesis carboxy-S- ∆3,∆2- UB40_RS02825 aspartate/ L-alanine VII small subunit: xseB galactosidase UB40_RS04470 CheZ: A 0 dehydratase/ synthase: rsmI methyltransferase: RsmD: rsmD UB40_RS11740 dehydrogenase: ElbB: elbB UDP-N- acetylglucosamine α tyrosine/aromatic adiA large: acetylglucosaminyltransferase: subunit beta: (thiol)-lyase: aminopeptidase: a 2'-O- an N 2 - UB40_RS00350 a 2'- reductase: nrdD KDO transferase: -Kdo-(2->6)- Amino Acid Biosynthesis biosynthesis II (Vibrio) adenosyl-L- a 7-aminomethyl-7- NAD(P)H-hydrate enoyl-CoA fumarate agmatine degradation IV [+ 2 isozymes] UB40_RS14260 alpha- 4-O-phospho- acetylmuramoyl- D-glyceraldehyde D-glyceraldehyde gly gltB gltB murG UB40_RS11525 pepA 1402 prmC 966 UB40_RS19965 a peptide his glycolate deacetylase: lpxC lipid IV (E. coli) pyruvate pyruvate methionine 34 aminotransferase: UB40_RS08610 glucosidase: ygjK methylcytidine 5 methylguanine a [protein] Ser/Thr deoxyribonucleoside α-Kdo8N- UB40_RS11735 A 3-phosphate 3-phosphate deazaguanosine in tRNA epimerase: isomerase: glu a [release factor]-N tripeptide--D- UDP-3-O-(3- synthase UB40_RS02070 in 16S rRNA in 16S rRNA 5'-triphosphate (2->6)-lipid IV succinate α-Kdo-(2->4)-α-Kdo- 3-deoxy-D-manno- superpathway of L- SAM GTP tRNA preQ1(34) S- UB40_RS17870 fadB agmatinase: ala -methyl-L-glutamine A alanyl-D- alanine hydroxydecanoyl) L-lysine biosynthesis I superpathway of L-homoserine L-tryptophan biosynthesis CmoA: cmoA oxaloacetate pyruvate decaprenyl-pyrophosphoryl- a ribonucleoside a single-stranded a holo-[EntB aryl- XXXG xyloglucan a peptide with (2->6)-lipid IV (E. coli) α octulosonic isoleucine biosynthesis I L-histidine biosynthesis superpathway of L-methionine superpathway L-selenocysteine biosynthesis I (bacteria) GTP adenosylmethionine (2E)-dodec- L-glutamate speB UDP 3',5'-ADP a proteinogenic A ligase: murF - -D-glucosamine L-proline 1-deoxy-D- 1-deoxy-D- alanine (N-acetylglucosamine)-N- 5'-monophosphate oligodeoxyribonucleotide carrier protein] D-galactopyranose succinate D-glucopyranose maltotetraose acid kinase: biosynthesis (transsulfuration) and L-methionine biosynthesis of L-threonine cyclohydrolase NADH 2-enoyl-CoA oligosaccharide L-homocysteine an N-terminal UDP-3-O-(3- biosynthesis I xylulose-5- xylulose-5- a 5- S-adenosyl-S- ribosyltransferase- degradation IX (via dehydrogenase: ald acetylmuramyl-(pentapeptide) amino acid UB40_RS11740 oxaloacetate biosynthesis 7,8- I FolE: folE putrescine L-proline UDP-N-acetyl- hydroxymyristoyl) PRPP (from L-glutamate) gln sec phosphate phosphate 34 isomerase QueA: queA fatty acid 4-aminobutanoate) alanine α oxaloacetate asp chorismate ser a tRNA SAH dihydroneopterin hydroxyuridine carboxymethyl- α-D-muramoyl- glucosamine N- 4-O-phospho- - aspartate/ asp oxaloacetate synthase: dxs synthase: dxs oxidation dehydrogenase: ald bifunctional selenide 3'-triphosphate in tRNA L-homocysteine 34 L-alanyl-γ-D- Kdo-(2->6)-lipid IV tyrosine/aromatic ATP glu an epoxyqueuosine in tRNA glu pyruvate a [glycine-cleavage XLLG xyloglucan an N-acetyl-β- 1402 cytidine 2',3'-cyclic 2552 α 1498 D-myo-inositol a [lipoyl-carrier LpxL/LpxP acyltransferase: A aspartate/ aspartate kinase/ aspartate/ 5'-methylthioadenosine/ complex 6-[1-hydroxyethyl]-7- coenzyme A [EntF L-seryl- an (R)-2- maltotriose a cytidine uridine a [protein]- - a uracil β-D-allopyranose aminotransferase: phosphoribosyltransferase bifunctional anthranilate 6-carboxytetrahydropterin glutamate a sulfurated [sulfur carrier] SAM complex H protein] oligosaccharide D-hexosaminide monophosphate (1,3,4,5)- protein]-N 6 -[(R) Ap4A a DNA segment family Kdo(2)- glutamyl-meso-2,6- di-trans,octa-cis lpxD tyrosine/aromatic homoserine tyrosine/aromatic glutamate 5- serine--tRNA selenide, 1-deoxy-D-xylulose 1-deoxy-D-xylulose S-adenosylhomocysteine tRNA 5- tRNA subunit alpha methyl-7,8-dihydropterin carrier protein] halocarboxylate in 16S rRNA in 23S rRNA L-glutamate in 16S rRNA UB40_RS12270 regulatory subunit: aspartate kinase/ synthase component synthase: UB40_RS09625 decarboxylase: N 6 -octanoyl-L-lysine 2-amino-4-hydroxy-6- 16S rRNA bifunctional 2',3'- 23S rRNA 16S rRNA tetrakisphosphate -dihydrolipoyl]- D-ribose lipid IV(A) lauroyl/ diaminopimeloyl- -undecaprenyl UDP-2-N-[(3R)-3- aminotransferase: dehydrogenase aminotransferase: kinase: proB ligase: serS water dikinase 5-phosphate 5-phosphate nucleosidase: methoxyuridine(34) epoxyqueuosine(34) FadB: fadB protein-glutamate O- inosine/ symmetrical D-alanyl-D-alanine hydroxydodecanoyl]- UB40_RS17710 homoserine γ-L-glutamyl 1: UB40_RS01455 UB40_RS19180 hydroxymethyldihydropteridine (cytosine(1402)-N(4) cyclic-nucleotide 2'- (uridine(2552)-2'-O) (uracil(1498)-N(3))- L-lysine recombinase pyranase: palmitoleoyl phosphate aspartate/ UB40_RS12270 II: UB40_RS11520 UB40_RS12270 SelD: selD 1-deoxy-D-xylulose- 1-deoxy-D-xylulose- UB40_RS12305 6-carboxy-5,6,7,8- /uridine 5-oxyacetic reductase QueG: queG (S)-3- beta- HAD family alpha-glucosidase: beta-N- methyltransferase: xanthosine dihydrolipoyl bis(5'-nucleosyl)- 3-O-[(3R)-3- ATP dehydrogenase 5-phosphate 4-aminobutanoate diphosphokinase: folK holo-ACP )-methyltransferase phosphodiesterase/ -methyltransferase methyltransferase: RecA: recA rbsD lauroyl acyltransferase: tyrosine/aromatic [+ 2 isozymes] aspartate/ 5-phosphate 5-phosphate [+ 2 isozymes] tetrahydropterin acid(34) synthase hydroxydodecanoyl-CoA lipoyl galactosidase hydrolase: UB40_RS04470 acetylhexosaminidase: UB40_RS00140 triphosphatase: dehydrogenase: tetraphosphatase: aspartate/ II: UB40_RS11520 an L-seryl-[tRNA sec ] 34 2-amino-4-hydroxy-6- synthase: RsmH: rsmH 3'-nucleotidase: RlmE: rlmE a [protein]-L- rsmE a DNA segment acyltransferase: lpxL phospho-N- hydroxydecanoyl]- aminotransferase: phosphoribosyltransferase: tyrosine/aromatic glutamate-5- selenophosphate reductoisomerase: reductoisomerase: 7-carboxy-7- CmoB: cmoB a queuosine in tRNA subunit beta: alpha- UB40_RS10055 an N 4 - a 2'-O- an N 3 - D-myo-inositolyjjX lpdA UB40_RS13500 β-D-allofuranose tyrosine/aromatic L-aspartyl-4-phosphate anthranilate PRPP fatty acid synthase: lipA UB40_RS14260 UB40_RS03975 UB40_RS17635 5 a [lipoyl-carrier lpxL acetylmuramoyl- α-D-glucosamine hisG [+ 2 isozymes] semialdehyde hydroxymethyldihydropteridine 1402 2552 glutamate-O 1498 in reverse UB40_RS02070 aminotransferase: ispC ispC S-ribosyl-L-homocysteine deazaguanine UB40_RS08610 glucosidase: ygjK [+ 2 isozymes] methylcytidine methyluridine methyluracil (1,3,4)- 6 ADP LpxL/LpxP aminotransferase: oxidation diphosphokinase: folK [+ 3 isozymes] 3'-cmp -methyl-ester protein]-N -[(R orientation pentapeptide- UDP-2,3- UB40_RS02070 dehydrogenase: synthase a 5-(carboxymethoxy) [1-(2-amino-7-methyl-4-oxo- in 16S rRNA in 23S rRNA in 16S rRNA trisphosphate family Kdo(2)- asp 1-(5-phospho-β-D-ribosyl)-ATP UB40_RS02070 aspartate- L-aspartyl- L-seryl-tRNA(Sec) 5-oxo-L-proline metabolism complex a [glycine-cleavage a holo-[EntF )-lipoyl]-L-lysine transferase: mraY diacylglucosamine UB40_RS16645 anthranilate MEP MEP uridine 34 in tRNA β lipid IV(A) lauroyl/ 4-phosphate asp S-ribosylhomocysteine QueE: queE subunit alpha 6 an unsulfurated 7,8-dihydro-3H-pteridin- 3',5'-ADP XXXG xyloglucan an N-acetyl- - diphosphatase: lpxH semialdehyde phosphoribosyltransferase: trpD selenium 5'-deoxyadenosine met complex H protein] N L-seryl-carrier D-galactopyranose an (S)-2- D-glucopyranose maltose palmitoleoyl bifunctional bifunctional L-glutamate-5- lyase: luxS tRNA cmo 5 U34 a [protein] with a [protein] with Carbohydrate Degradation 6-yl)]ethyl diphosphate oligosaccharide a halide anion an alcohol D-hexosamine undecaprenyldiphospho- asp dehydrogenase: transferase: selA 2-C-methyl-D- 2-C-methyl-D- 7-carboxy-7- FadJ: fadJ -[(R)-lipoyl]-L-lysine [sulfur carrier] protein] acyltransferase: aspartate kinase/ phosphoribosyl- aspartate- semialdehyde methyltransferase: an N-terminal an N-terminal hydroxycarboxylate N-acetylmuramoyl-L- lipid X (P. putida) UB40_RS13945 bifunctional erythritol 4-phosphate erythritol 4-phosphate deazaguanine lpxL homoserine AMP cyclohydrolase/ semialdehyde N-(5-phosphoribosyl)-anthranilate AI-2 cmoM L-glutamine L-glutamate 3-oxododecanoyl-CoA alanyl-γ-D-glutamyl-meso bifunctional aspartate kinase/ cytidylyltransferase: cytidylyltransferase: 7-cyano-7- Entner-Doudoroff pathway I lipid-A- aspartate- dehydrogenase: sec chitin derivatives degradation ribose D-galactosamine and N- dehydrogenase phosphoribosyl-ATP aspartate kinase/ homoserine an L-selenocysteinyl-[tRNA ] a 5-(methoxycarbonylmethoxy) a thiocarboxylated cyclic peptidoglycan D- an [apo BCAA uridine 2'3'-cyclic 46 type-1 an organic CTP -2,6-diaminopimeloyl- semialdehyde UB40_RS13945 bifunctional indole-3-glycerol- ispD ispD deazaguanine acetyl-CoA C- phosphorylation acetyl-D-galactosamine a [pyruvate dehydrogenase E2 a proteinogenic an isoprenoid an (S)-2- a ribonucleoside a single a guanine an insertion sequence 3'-cmp N-acetyl-L- a [protein]- disaccharide II: UB40_RS11520 diphosphatase HisIE: 34 D-glucopyranose 6 leukotriene-C4 [SAMP] C- pyranopterin dehydrogenase E2 protein] monophosphate α α D-alanyl-D-alanine homoserine dehydrogenase 4-(cytidine 5'- 4-(cytidine 5'- synthase uridine in tRNA acyltransferase N,N'- a sulfurated [sulfur carrier] SAM protein] N -octanoyl-L-lysine 4-hydroxybenzoate diphosphate halocarboxylate triphosphate alanyl-DAP crosslink in tRNA element IS30 transmembrane L-histidine hydroperoxide dCTP -Kdo-(2->4)- - synthase: lpxB dehydrogenase: phosphate synthase TrpC/ autoinducer AI-2 biosynthesis I degradation amino acid stranded DNA 6 bifunctional 2',3'- glutamate [+ 2 isozymes] UB40_RS01065 dehydrogenase aspartate- II: UB40_RS11520 (S)-1-pyrroline- 6-phosphate β terminal glycine phosphate N -dihydrolipoyl-L-lysine tRNA bifunctional 2',3'- proteins thiol Kdo-(2->6)-(lauroyl) undecaprenyldiphospho- asd phosphoribosylanthranilate diphospho)-2-C- diphospho)-2-C- QueC: queC a [protein] with FadI: fadI diacetylchitobiose -D-ribopyranose N-acetyl-D- dihydrolipoyl rhomboid family histidine kinase: deaminase: Kdo -(palmitoleoyl) lipid A II: UB40_RS11520 semialdehyde 5-carboxylate (2S,4S)-2-methyl-2,4- glucose-6- cyclic-nucleotide 2'- (guanosine(46)-N7) transposase: cyclic-nucleotide 2'- peroxidase: -lipid IV (E. coli) 2 muramoylpentapeptide beta-N- L-aspartyl- β [+ 2 isozymes] isomerase TrpF: trpCF methyl-D-erythritol methyl-D-erythritol an N-terminal 5- acetyl-CoA C- D-ribose galactosamine HAD family murein DD- dehydrogenase: acetylglutamate intramembrane UB40_RS01305 dcd A -lipid IV disaccharide 1-(5-phospho- -D-ribosyl)-AMP L-aspartate 4- dehydrogenase: dihydroxydihydrofuran-3-one preQ 4-hydroxybenzoate DNA phosphodiesterase/ -methyltransferase UB40_RS10590 phosphodiesterase/ tpx lauroyl-Kdo(2) A acetylglucosaminyltransferase: [+ 2 isozymes] pyrroline-5- 4-(cytidine 5'- 4-(cytidine 5'- SAM 0 phosphate pyranase: 6-phosphate molybdopterin kinase: argB serine protease [+ 6 isozymes] (P. putida) 4-phosphate semialdehyde asd L-aspartyl- 1-(2-carboxyphenylamino)-1- γ-L-glutamyl oxo-L-proline acyltransferase gamma- octaprenyltransferase: hydrolase: primase: endopeptidase lpdA 3'-nucleotidase: TrmB: trmB an insertion 3'-nucleotidase: a [protein]- UTP -lipid IV(A) lauroyl-Kdo(2) murG carboxylate diphospho) diphospho) dehydrogenase: rbsD N-acetylglucosamine- lipoyl synthase: lipA synthase: an [apo BCAA an N 7 - GlpG: glpG [+ 2 isozymes] tetraacyldisaccharide bifunctional L-aspartyl- 4-phosphate deoxy-D-ribulose 5-phosphate 5-phosphate glutathione FadA: fadA N,N'- glutamyltransferase: ggt ubiA UB40_RS03975 dnaG MepM: mepM UB40_RS17635 sequence IS30 with UB40_RS17635 N-acetylglutamyl- cleaved type-1 N-phospho- -lipid IV(A) lipid II (meso aspartate- 4-hydroxy- L-aspartate 4- reductase: -2-C-methyl- -2-C-methyl- pyroglutamyl- UB40_RS17260 β-D-ribofuranose moaE moaD dehydrogenase E2 methylguanine 46 an alcohol myristoyltransferase: phosphoribosyl- ammonia assimilation cycle III diacetylchitobiose 6-phosphate [+ 3 isozymes] phosphate transmembrane myristoyltransferase: diaminopimelate 4'-kinase: lpxK semialdehyde 4-phosphate tetrahydrodipicolinate semialdehyde aspartate- UB40_RS20090 bifunctional indole-3-glycerol- D-erythritol D-erythritol peptidase decanoyl-CoA 6-phospho protein] N 6 -lipoyl-L-lysine 3'-UMP in tRNA integrated transposon cytidine L-histidine lpxM AMP cyclohydrolase/ (2S,4S)-2-methyl-2,3,3,4- SAH deacetylase: nagA peptidoglycan peptidoglycan proteins α-D-Kdo-(2->4) lpxM containing) lipid IV dehydrogenase: synthase: dapA semialdehyde phosphate synthase TrpC/ kinase: ispE kinase: ispE I: pcp D-glucono- N,N'- a [pyruvate dehydrogenase an α-(γ-L-glutamyl) a 4-hydroxy-3- ssDNA/pppN(pN) A phosphoribosyl-ATP aspartate- bifunctional ammonium tetrahydroxytetrahydrofuran [+ 2 isozymes] 5'-deoxyadenosine leukotriene-D4 a [SAMP] C- tetrapeptide, tetrapeptide, α (Kdo) -lipid (P. putida) UB40_RS13945 (2S,4S)-4- pro phosphoribosylanthranilate 2-phospho-4-(cytidine 2-phospho-4-(cytidine acyl-CoA 1,5-lactone met 6 an unsulfurated [sulfur carrier] molybdopterin an (S)-2- - -D-Kdo-(2->6) 2 diphosphatase HisIE: semialdehyde dehydrogenase: diacetylchitobiose E2 protein] N -lipoyl-L-lysine -L-amino acid polyprenylbenzoate hybrid hydroxy-2,3,4,5- aspartate kinase/ isomerase TrpF: trpCF 5'-methylthioadenosine/ D-galactosamine terminal glycine a halide anion n -1 glycan chain 1 glycan chain 2 -lipid A (E. coli) A, cold adapted UB40_RS13945 5'-diphospho)-2-C- 5'-diphospho)-2-C- 6 37 dehydrogenase: 6-phosphogluconolactonase: phosphorylase: hydroxycarboxylate aspartate- UB40_RS01065 dehydrogenase: tetrahydrodipicolinate homoserine glu S-adenosylhomocysteine N -L-threonylcarbamoyladenosine 5-oxo-L-proline D-ribofuranose 6-phosphate β (1S,2R)-1-C-(indol-3- 2-oxoglutarate methyl-D-erythritol methyl-D-erythritol UB40_RS01735 pgl UB40_RS10050 semialdehyde 1-(5-phospho- -D-ribosyl)- UB40_RS13945 4-hydroxy- dehydrogenase aspartate- glutamate- nucleosidase: -modified tRNA biosynthesis D-galactosamine- yl)glycerol 3-phosphate glutamate 2-C-methyl-D- 2-C-methyl-D- (2S,4S)-2-methyl-2,3,3,4- lipoprotein posttranslational modification acyl-CoA ribokinase: dehydrogenase: 5-[(5-phosphoribosylamino) aspartate- II: UB40_RS11520 semialdehyde -ammonia UB40_RS12305 5-oxoprolinase: D-gluconate N-acetyl-D- a nucleoside 1207 37 a supercoiled uridine tetrahydrodipicolinate synthase imidazole erythritol 2,4- erythritol 2,4- tetrahydroxytetrahydrofuran- dehydrogenase: rbsK 6-phosphate a 5-L-glutamyl- a proteinogenic glutathione a lipid II a single- an (S)-2- RNA a 9S rRNA a guanine guanine 4-nitrocatecholsulfate 3'-UMP wound RNA an aryl sulfate asd methylideneamino]imidazole- dehydrogenase: pxpB 6-phosphate glucosamine cyclic 3',5'- Phe semialdehyde reductase: dapB bifunctional tryptophan large: gltB gltB glycerol ligase: glnA cyclodiphosphate cyclodiphosphate borate [+ 2 isozymes] thr deaminase/ an amino acid stranded RNA halocarboxylate in 16S rRNA in tRNA met duplex DNA Aromatic Compound Biosynthesis 4-carboxamide asd UB40_RS20020 UB40_RS18100 D-ribofuranose [peptide] amino acid monophosphate 16S rRNA tRNA sulfatase: bifunctional 2',3'- ATP-dependent sulfatase: DNA uridine L-aspartate 4- dehydrogenase: (S)-2,3,4,5- aspartate kinase/ synthase: trpA trpB phosphate synthase: ispF synthase: ispF threonylcarbamoyl- a [prolipoprotein]-L-cysteine phosphogluconate isomerase: 1-(5-phosphoribosyl)-5- N-acetyl-α-D- N-acetylglucosamine 5-phosphate 3',5'-cyclic-nucleotide (guanine(1207)-N(2) (guanosine(37)-N1) UB40_RS09900 cyclic-nucleotide 2'- RNA helicase: amino-acid N- UB40_RS09900 helicase kinase: udk semialdehyde asd tetrahydrodipicolinate homoserine L-aspartate 4- synthase S-ribosyl-L-homocysteine AMP synthase: (2E)-dec-2-enoyl-CoA dehydratase: UB40_RS09885 penicillin-binding chorismate biosynthesis I [(5- phosphoribosylamino) ser 2-C-methyl-D-erythritol- 2-C-methyl-D-erythritol- glu prolipoprotein glucosamine kinase: polyribonucleotide HAD family ribonuclease T2: ribonuclease phosphodiesterase: )-methyltransferase -methyltransferase sulfatase: phosphodiesterase/ UB40_RS03905 acetyltransferase: sulfatase: Rep: rep 3-(4-hydroxyphenyl) L-aspartate 4- dehydrogenase semialdehyde indole ammoniumsubunit gln UB40_RS01465 UB40_RS17535 D-tagatofuranose protein 2: mrdA bifunctional methylideneamino]imidazole-4- 2,3,4,5- 2,4-cyclodiphosphate 2,4-cyclodiphosphate diacylglyceryl ∆ 2 1-phosphate UB40_RS10060 gamma- gamma- nucleotidyltransferase: pnp hydrolase: UB40_RS02530 E: rne UB40_RS07685 RsmC: rsmC TrmD: trmD 3'-nucleotidase: argA UMP pyruvate biosynthesis I: thrA HisH: hisH S-ribosylhomocysteine trans- - an N 2 - an N 1 - UB40_RS12115 [+ 5 isozymes] UB40_RS12115 [+ 5 isozymes] D-erythrose aspartate kinase/ carboxamide isomerase: hisA semialdehyde tetrahydropyridine- bifunctional L-threonylcarbamoyladenylate transferase: lgt 6-phosphate glutamyltransferase: ggt glutamyltransferase: ggt [+ 2 isozymes] UB40_RS03975 a nucleoside 5'- UB40_RS17635 N-acetyl-L- a single flavodoxin- flavodoxin- lyase: luxS decenoyl-CoA KDGP N-acetylglucosamine methylguanine 1207 37 4-nitrocatechol an unwound RNA a phenol 4-phosphate homoserine 2,6-dicarboxylate N- aspartate kinase/ tryptophan [+ 7 isozymes] (L-threonylcarbamoyl)synthase type 1 TsaC: tsaC chitobiose tagatose-6- [+ 3 isozymes] monophosphate methylguanine stranded DNA bifunctional a [prolipoprotein]-S-1,2- hydratase: kinase: nagK Phe uridine methionine 3-deoxy-7- tyr phosphoribulosylformimino- L-homoserine dependent dependent 6'-phosphate a N-acetylglucosamine--N- an [RNA]-3'- a 5'-hydroxy- in 16S rRNA in tRNA dehydrogenase aspartate kinase/ succinyltransferase: homoserine synthase: trpA trpB AI-2 adenylate diacyl-sn-glyceryl-L-cysteine fadB phosphate an α-(5-L- a nucleoside a single- phosphoheptulonate aspartate/ AICAR-phosphate (E)-4-hydroxy- (E)-4-hydroxy- an α-(γ-L-glutamyl) acetylmuramyl-(tetrapeptide) ribonucleoside- ribonucleotide- a 5S rRNA an rRNA fragment II: UB40_RS11520 homoserine dapD dehydrogenase tRNA (adenosine(37)-N6)- bifunctional N-acetyl-D- kinase: pfkA glutamyl)- L-cysteinylglycine D-ala diphosphate stranded RNA synthase: tyrosine/aromatic homoserine O- 3-methylbut- 3-methylbut- (S)-3- a peptide -L-amino acid pyrophosphoryl-undecaprenol a (2R)-2- 3'-phosphate 3'-[RNA] bifunctional dehydrogenase N-succinyl-2-amino- II: UB40_RS11520 glu threonylcarbamoyltransferase signal peptidase 4-hydroxy-2- glucosamine D-tagatofuranose amino acid a halide anion UB40_RS14515 aminotransferase: imidazole glycerol succinyltransferase: trp 2-enyl- 2-enyl- hydroxydecanoyl-CoA hydroxy fatty acid aspartate kinase/ II: UB40_RS11520 6-ketopimelate bifunctional diphosphate diphosphate complex ATPase subunit II: lspA oxoglutarate 6-phosphate 1,6-bisphosphate 3-deoxy-[+ 2 isozymes] UB40_RS02070 phosphate synthase metA (S)-3- D-glucosamine homoserine subunit HisH: hisH bifunctional aspartate kinase/ synthase: ispG synthase: ispG (2R,4S)-2-methyl-2,4- type 1 TsaE: tsaE signal peptidase aldolase/2- D-arabino- O-succinyl-L- hydroxydecanoyl- N-acetylglucosamine- α undecaprenyl-diphospho-N a peptidoglycan dimer (meso 967 1618 37 aspartate/ dehydrogenase cys homoserine L-phenylalanine [+ 2 isozymes] II: lspA dehydro-3-deoxy- tagatose- UDP-N-acetyl- -D-glucosamine RNase R degradation an (R)-2- a long-chain + all-trans- a cytosine adenine a guanine 54 a negatively an organic cytidine aspartate kinase/ (E)-4-hydroxy-3- (E)-4-hydroxy-3- dihydroxydihydrofuran-3-one CoA γ glutathione NADPH H a uracil in tRNA Ins(5)P DNA with lesion heptulosonate tyrosine/aromatic I: thrA homoserine an N 6 -L- phosphogluconate 6-phosphate glucosamine bisphosphate -acetylmuramoyl-L-alanyl- - hypoglycin A -diaminopimelate containing) substrate RNA halocarboxylate fatty acyl-CoA retinyl palmitate in 16S rRNA in 23S rRNA in tRNA supercoiled DNA glu hydroperoxide homoserine dehydrogenase biosynthesis I methylbut-2-en- methylbut-2-en- dehydrogenase: 7-phosphate aminotransferase: AICAR D-erythro-1-(imidazol-4- N-succinyl-L,L-2,6- 37 deacetylase: nagA kinase: D-galactose degradation I (Leloir pathway) aldolase D-glutamyl-L-lysyl- D-alanine 16S rRNA 23S rRNA tRNA tRNA DNA excinuclease alkyl uridine dehydrogenase I: thrA superpathway of branched chain amino acid biosynthesis 1-yl diphosphate 1-yl diphosphate threonylcarbamoyladenine an (S-diacyl-sn-glyceryl)-L- aldolase: inositol-1- amino-acid N- 3-dehydroquinate 3-(4- UB40_RS12270 L-homoserine yl)-glycerol 3-phosphate diaminopimelate glycine a lipoprotein signal peptide fadJ [+ 2 isozymes] UB40_RS10060 subunit undecaprenyldiphospho- (cytosine(967)-C(5) (adenine(1618)-N(6) (guanosine(37)-N1) (uridine(54)-C5)- topoisomerase III: ABC subunit hydroperoxide kinase: udk I: thrA O-succinylhomoserine chorismate 4-hydroxy- 4-hydroxy- in tRNA cysteinyl-[apolipoprotein] UB40_RS19050 penicillin-binding HAD family acyl-CoA monophosphatase: acetyltransferase: synthase: aroB hydroxyphenyl) succinyl- (thiol)-lyase: bifunctional biosynthesis IV β KbaZ: kbaZ muramoylpentapeptide beta-N- ribonuclease carboxylesterase: )-methyltransferase )-methyltransferase -methyltransferase methyltransferase UB40_RS07535 UvrC: uvrC reductase: bifunctional histidinol- L-homoserine pyruvate 3-methylbut- 3-methylbut- (2R,4S)-2-methyl-2,3,3,4- apolipoprotein N- signal peptide 3-oxodecanoyl-CoA [+ 2 isozymes] -D-galactopyranose gamma- protein 2: mrdA hydrolase: reductase: suhB argA CMP pyruvate diaminopimelate thr D-glucosamine acetylglucosaminyltransferase: R: rnr UB40_RS11280 RsmB: rsmB 6 RlmF: rlmF 1 TrmD: trmD TrmA: trmA [+ 2 isozymes] [+ 3 isozymes] ahpF ahpC homoserine phosphatase/ UB40_RS11525 chorismate mutase/ 2-enyl 2-enyl tetrahydroxytetrahydrofuran peptidase [+ 2 isozymes] UB40_RS09585 967 an N - an N - 54 3-dehydroquinate L-homoserine acyltransferase: lnt 6-phosphate glutamyltransferase: ggt UB40_RS03975 a 5-methylcytosine a 5-methyluracil myo-inositol N-acetyl-L- DNA without kinase: thrB imidazoleglycerol- desuccinylase: homoserine acetolactate prephenate thr diphosphate diphosphate SppA: sppA fatty acid D-glyceraldehyde galactose-1-epimerase: galM D-glyceraldehyde murG methyladenine 1618 methylguanine 37 a relaxed DNA an alcohol myo-inositol an N-acyl-(S-diacyl- pyruvate DHAP [+ 3 isozymes] in 16S rRNA in tRNA glutamate lesion phosphate homoserine O- dapE kinase: thrB threonine synthase dehydrogenase: low specificity reductase: reductase: N-end rule pathway I (prokaryotic) oxidation 3-phosphate 3-phosphate a peptidoglycan with in 23S rRNA in tRNA type II 3- O-phospho- L-cystathionine 4-hydroxy- 4-hydroxy- biosynthesis sn-glyceryl)-L- ditrans,octacis-undecaprenyldiphospho- a nucleoside 5'- a long-chain dehydratase succinyltransferase: ammonia- AlsS: alsS tyrA L-threonine ispH ispH a peptide complex α UDP a diribonucleotide all-trans-retinol palmitate dehydroquinate 3-methylbut- 3-methylbut- leucyl/ cysteinyl-[lipoprotein] type I -D-galactopyranose hypoglycin B L-cysteinylglycine D,D cross-links (meso- D-ala monophosphate fatty aldehyde L-homoserine HisB: hisB metA L,L-diaminopimelate O-phospho- lyase, prephenate aldolase: D-glucopyranose subunit alpha N-acetyl-(N-acetylglucosaminyl)muramoyl- a (2R)-2- dehydratase: aroQ [+ 2 isozymes] 2-enyl 2-enyl glyceraldehyde- α-D-glucosamine γ diaminopimelate containing) a halide anion threonine cystathionine L-homoserine biosynthetic: UB40_RS04990 IPP IPP 6-phosphate phenylalanyl- FadB: fadB L-alanyl- -D-glutamyl-L-lysyl-D-alanine hydroxy fatty acid 3-(imidazol-4-yl)-2- O-succinyl-L- diphosphate diphosphate 3-phosphate 6-phosphate galactokinase: galK 3-dehydroshikimate synthase: cys diaminopimelate beta-lyase: ilvA (S)-2-acetolactate prephenate tRNA--protein [+ 3 isozymes] oxopropyl phosphate homoserine threonine low-specificity reductase: reductase: dehydrogenase: thrC epimerase: dapF metC (2Z)-2-aminobut- dehydratase: transferase: glucosamine- synthase: L-threonine ispH ispH a [protein] gap 10 XLXG xyloglucan N-acetyl-9-O- an N-acyl-D- 745 1939 34 shikimate histidinol-phosphate ketol-acid pheA isopentenyl- isopentenyl- Ins(3)P aat octanoyl-CoA 6-phosphate α α an L-methionyl- an N - an N-terminal L- an L-arginyl- + maltohexaose a guanine a uracil maltose an adenine thrC 2-enoate aldolase: ltaE an N-terminal N-terminal L- -D-galactose 1-phosphate UDP- -D-glucose oligosaccharide H hydrogencarbonate an all-trans-retinyl ester mannosamine an acyl phosphate Ins(4)P a dipeptide CAIR dehydrogenase: transaminase: L-homocysteine reductoisomerase: diphosphate diphosphate deaminase: Met formyltetrahydrofolate aspartyl-[protein] [tRNA Arg ] acetylneuraminate in 23S rRNA in 23S rRNA in tRNA thr O-succinylhomoserine meso-diaminopimelate 3-phenyl-2- gly arginyl-[protein] [initiator tRNA ] 23S rRNA 23S rRNA tRNA 5-(carboxyamino) aroE UB40_RS01090 ilvC Delta- Delta- inositol-1- leucyl-L-arginine acyl-CoA 13-DPG UB40_RS12945 chitin degradation II (Vibrio) N-acetylmannosamine maltose inositol-1- membrane (thiol)-lyase: thr oxopropanoate (guanine(745)-N(1)) (uracil(1939)-C(5)) acylphosphatase: adenosine(34) imidazole methionine methionine (2R)-2,3-dihydroxy- isomerase: idi isomerase: idi monophosphatase: dehydrogenase: beta- alpha-glucosidase: kinase: acetyltransferase: monophosphatase: dipeptidase: threonine UB40_RS11525 diaminopimelate aspartate/ phosphoglycerate glucosamine- carbonate sialate O- carboxylesterase: -methyltransferase: -methyltransferase yccX deaminase ribonucleotide shikimate L-histidinol phosphate synthase: synthase: 3-methylbutanoate suhB leucyl/ UB40_RS01735 chitin arginyltransferase: galactosidase UB40_RS04470 UB40_RS09810 UB40_RS04370 suhB UB40_RS09700 ammonia- decarboxylase: lysA 2-iminobutanoate tyrosine/aromatic kinase: 6-phosphate methionyl-tRNA dehydratase: acetylesterase: UB40_RS11280 an N-acyl-α-D- rlmA RlmD: rlmD 6-O-acetyl-α-D- TadA: tadA mutase: purE metH metH phenylalanyl- acyl-CoA UB40_RS07185 subunit beta: an N 1 - shikimate lyase, diaminopimelate dihydroxy-acid aminotransferase: DMAPP DMAPP UB40_RS14100 deaminase: chitinase: formyltransferase: fmt can alpha- UB40_RS04150 mannosamine a 5-methyluracil 1939 a carboxylate glucopyranosyl- myo-inositol a proteinogenic a hypoxanthine bifunctional histidinol- L-cystathionine myo-inositol tRNA--protein dehydrogenase: UB40_RS08610 methylguanine 745 AIR kinase biosynthetic: decarboxylase: lysA dehydratase: UB40_RS02070 UB40_RS00820 UB40_RS10740 glucosidase: ygjK 6-phosphate in 23S rRNA (1->4)-D-glucose amino acid 34 in tRNAs phosphatase/ met ilvD transferase: UB40_RS18100 3-phospho- an N-terminal in 23S rRNA AroK: aroK ilvA aspartate/ a [protein] [+ 2 isozymes] imidazoleglycerol- cystathionine aat D-glycerate F6P an N-formyl- a tRNA Arg L-arginiyl-L- CO H O acetate N-acetylneuraminate all-trans-retinol a fatty acid lys 3-methyl-2- an N-terminal XXXG xyloglucan 2 2 shikimate 3- (2Z)-2-aminobut- phosphate beta-lyase: tyrosine/aromatic L-alanine N-terminal L- (2E)-oct-2-enoyl-CoA L-methionyl- a tetrahydrofolate D-galactopyranose D-glucopyranose maltopentaose L-tyrosine biosynthesis I 2-oxobutanoate oxobutanoate L-lysyl-[protein] 2,3- a chitodextrin aspartyl-[protein] oligosaccharide phosphate 2-enoate dehydratase metC aminotransferase: biosynthesis III leucyl-L-lysine diphosphoglycerate- [initiator tRNA met ] HisB: hisB UB40_RS12270 fatty acid 3-phosphoshikimate 1- chorismate acetolactate 2-isopropylmalate oxidation dependent L-homocysteine L-methionine biosynthesis II branched-chain- cys carboxyvinyltransferase: synthase phosphoglycerate a [formate C an N-terminal L- a [DNA]-3'- N-acetyl-4-O- uridine 2457 a double-stranded an adenosine 34 histidinol bifunctional synthase: leuA amino-acid phe complex glucose and glucose-1-phosphate degradation an L-arginyl- phylloquinone NAD(P)H H + nicotinate uroporphyrinogen-III riboflavin aroA AlsS: alsS cysteine desulfurase mutase: gpmA a reduced flavodoxin SAM PRPP spermine L-ornithine Ins(2)P Arg2 ser acetyltransferase]-glycine glutamyl-[protein] Arg hydroxyl acetylneuraminate in 23S rRNA thr oligonucleotide in [tRNA ] 5-enolpyruvoyl- 2-iminobutanoate methionine methionine chorismate mutase/ transaminase: sulfur acceptor subunit alpha a chitodextrin [tRNA ] [+ 2 isozymes] 2-phospho- α-D- uroporphyrinogen-III 23S rRNA spermidine N1- NAD(P)H-flavin tRNA shikimate 3- histidinol synthase: synthase: L-homoserine prephenate (2S)-2-isopropylmalate ilvE subunit CsdE: csdE FadB: fadB L-threonine oligoribonuclease: arginine N- inositol-1- L-serine D-glycerate glucopyranose C-methyltransferase: pseudouridine(2457) acetyltransferase: reductase: fre adenosine(34) phosphate dehydrogenase: hisD metH metH dehydrogenase: (S)-2-aceto-2- (S)-3- NAD(P)H:quinone nicotinate sialate O- dehydrogenase: yiaY orn succinyltransferase: monophosphatase: ammonia-lyase: [+ 2 isozymes] 1-phosphate UDP-glucose-- pyruvate formate arginyltransferase: exodeoxyribonuclease cobA synthase RluE: rluE speG NAD(P)H-flavin deaminase chorismate tyrA hydroxybutanoate 3-isopropylmalate hydroxyoctanoyl-CoA phosphopyruvate oxidoreductase: phosphoribosyltransferase: acetylesterase: L-threonine 3- astA suhB UB40_RS01790 homoserine ala hexose-1-phosphate UDP-glucose 4- lyase 1-activating III: xthA [+ 4 isozymes] 2457 reductase: fre TadA: tadA histidinal prephenate val hydratase: eno UB40_RS07185 a pseudouridine a nucleoside 5'- 2 synthase: met kinase: thrB ketol-acid dehydratase: fatty acid uridylyltransferase: epimerase GalE: galE protein: pflA wrbA pncB UB40_RS04150 dehydrogenase: tdh N 1 -acetylspermine N -succinyl- an inosine 34 alpha-D-glucose sugar- precorrin-2 in 23S rRNA monophosphate myo-inositol reduced riboflavin pyruvate aroC 2-oxobutanoate reductoisomerase: leuC leuD superpathway of L-serine oxidation phosphopyruvate UB40_RS08625 beta-N- aminoacetone L-ornithine in [tRNA Arg2 ] histidinol bifunctional ilvC phosphate-specific phosphatase: an N-terminal a 2'- O-phospho- and glycine biosynthesis I complex hydratase: eno acetylhexosaminidase: a [formate C acetyltransferase]- a [DNA]-3'- chorismate acetolactate dehydrogenase: hisD chorismate mutase/ 2-isopropylmaleate phosphoglucomutase: yidA α-D-glucopyranose 1-phosphate UDP-α-D-galactose Arg L-arginiyl-L- + deoxyribonucleoside N-acetylneuraminate L-homoserine (R)-2,3-dihydroxy- subunit alpha phosphoenol nagZ 5'-deoxyadenosine a flavodoxin semiquinone met a tRNA NAD(P) phylloquinol NaMN hydroxyl acetate synthase prephenate pgm glycin -2-yl radical glutamyl-[protein] 5'-monophosphate O-succinylhomoserine 3-methylpentanoate 3-isopropylmalate 3-phospho-D-glycerate FadJ: fadJ pyruvate N,N'- [+ 2 isozymes] N,N',N''- AlsS: alsS his dehydrogenase: phospho- D-glucopyranose alpha-D-glucose (thiol)-lyase: dihydroxy-acid dehydratase: phosphoglycerate L-glutamate pyruvate diacetylchitobiose triacetylchitotriose [+ 2 isozymes] L-alanine L-cysteine biosynthesis I tyrA 3-oxooctanoyl-CoA sugar mutase: phosphate-specific UB40_RS11525 dehydratase: leuC leuD dehydrogenase: serA biosynthesis III kinase β biosynthesis I 3-(4- UB40_RS11085 lactose degradation II beta-N- UDP-N-acetyl-α-D-glucosamine undecaprenyl-diphospho-N-acetylmuramoyl-L- ADP-L-glycero- - heptosyl- D-cellobiose 955/2504/ 2604 a supercoiled D-mannopyranose γ (S)-2-aceto-2- ilvD phosphoglucomutase: pgm + S-(2-hydroxyacyl) uridine a uridine a myo-inositol -glutamyl- hydroxyphenyl) (2R,3S)-3- 3-phosphooxypyruvate acetyl-CoA C- PykF: pykF acetylhexosaminidase: alanyl-γ-D-glutamyl-L-lysyl- D-alanyl-D-alanine D-manno-heptose Kdo -lipid A NAD(P)H a plastoquinone H coenzyme A a [protein] Ser/Thr N-ethylmaleimide spermidine Ins(6)P hydroxybutanoate 3-methyl-2- 2 6'-phosphate glutathione 2580 in 23S rRNA in 23S rRNA monophosphate duplex DNA 6-phosphate isopropylamide ser L-cystathionine pyruvate (3S)-3-methyl-2- isopropylmalate 2-oxoglutarate phospho-sugar mutase: acyltransferase pyruvate D-glucopyranose α UB40_RS10055 23S rRNA 23S rRNA serine/threonine- spermidine N1- replicative mannose-6- ferredoxin- ketol-acid oxobutanoatebranched-chain- aspartate/ oxopentanoate 3-phosphoserine/ glutamate D-glucono- UB40_RS11085 -lactose undecaprenyldiphospho- inositol-1- alkene reductase: inositol-1- L-asparagine 3-isopropylmalate FadI: fadI kinase: pyk 6-phosphate [+ 2 isozymes] lipopolysaccharide pseudouridine(955/ pseudouridine(2604) protein kinase: acetyltransferase: DNA helicase: phosphate type protein reductoisomerase: amino-acid serine tyrosine/aromatic phosphohydroxythreonine synthase 1,5-lactone muramoylpentapeptide beta-N- NAD(P)H:quinone 6-phospho-beta- monophosphatase: UB40_RS11350 monophosphatase: biosynthesis I branched-chain- dehydrogenase: acetyl-CoA C- N-acetyl-D- heptosyltransferase CoA pyrophosphatase: hydroxyacylglutathione 2504/2580) synthase RluF: rluF UB40_RS16770 speG UB40_RS17765 isomerase, NapF: napF ilvC transaminase: acetyltransferase: cystathionine aminotransferase: transaminase: serC large: pyruvate D-glucopyranose 6-phosphate acetylglucosaminyltransferase: oxidoreductase: glucosidase: suhB suhB amino-acid leuB glucosamine UB40_RS01800 hydrolase: gloB synthase RluC: rluC 2604 [+ 2 isozymes] 1 [+ 4 isozymes] class I: manA γ beta-lyase: acyltransferase murG II: waaF 955/ a pseudouridine N - N-( -L-glutamyl) (R)-2,3-dihydroxy- ilvE UB40_RS16955 UB40_RS02070 transaminase: gltB gltB 3'-ketolactose wrbA UB40_RS04535 a pseudouridine a [protein] (L-serine/L- myo-inositol N-ethylsuccinimide myo-inositol a single asp metC (2S)-2-isopropyl- O-phospho-L-serine FadA: fadA in 23S rRNA acetylspermidine F6P -L-alaninol 3-methylpentanoate serine O- ilvE glu 2504/2580 in 23S rRNA threonine) phosphate stranded DNA val asparagine aspartate/ 3-oxosuccinate chitobiose degradation D-gluconate beta- (heptosyl) - dihydroxy-acid acetyltransferase: tyrosine/aromatic hexanoyl-CoA ditrans,octacis-undecaprenyldiphospho-N- UDP 2 D-glucopyranose a 2-hydroxy synthase 2-aminoprop- galactosidase ADP Kdo -lipid A a plastoquinol NAD(P) + D-glucopyranose 3',5'-ADP 4'-phosphopantetheine glutathione dehydratase: cysE phosphoserine acetyl-(N-acetyl-β-D-glucosaminyl)muramoyl-L- 2 6-phosphate carboxylate valine--pyruvate B: asnB L-homocysteine 2-enoate aminotransferase: ile N,N'-diacetylchitobiose subunit beta: ilvD phosphatase: serB acyl-CoA alanyl-γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine transaminase: asn UB40_RS12270 6'-phosphate UB40_RS08610 (3S)-3-methyl-2- UB40_RS16330 O-acetyl-L-serine hydrogen sulfide methionine 4-methyl-2- alanine dehydrogenase: 3-keto-β-D- oxopentanoate ser racemization UB40_RS01735 oxopentanoate synthase: tyr fructose degradation galactose α 1407 2605 a [protein]- RNase E N-monoacetylchitobiose 5-amino-4- β -maltose 6'- + methyl (indol- a cytosine uridine propane- D-mannitol branched-chain- ala metH branched-chain- acyl-CoA dethiobiotin a sulfurated SAM PRPP a -D-galactoside NADP coenzyme A citrate maltose chloramphenicol Ins(1)P N π -phospho- degradation cysteine 2-iminopropanoate serine 6'-phosphate imidazolecarboxyamide phosphate 3-yl)acetate in 16S rRNA in 23S rRNA 1,3-diamine 1-phosphate amino-acid amino-acid ala dehydrogenase: β-D-fructofuranose [sulfur carrier] 16S rRNA bifunctional alpha-glucosidase: L-histidine substrate mRNA synthase A: cysK hydroxymethyltransferase: 6-phospho-beta- 23S rRNA spermidine N1- CatB-related O- inositol-1- sugar- transaminase: met transaminase: alanine UB40_RS18100 1-phosphate (cytosine(1407)-C(5) aconitate hydratase UB40_RS04470 phosphohistidine UB40_RS16445 glucosidase: beta-galactosidase pseudouridine(2605) acetyltransferase: acetyltransferase: monophosphatase: ribonuclease phosphatase: ilvE ilvE racemase: 1-phosphofructokinase: D-galactopyranose biotin adenine 6-phospho-alpha- CoA-disulfide carboxylesterase: )-methyltransferase 2/2-methylisocitrate alpha- phosphatase (2E)-hexenoyl-CoA UB40_RS04535 subunit beta: synthase RluB: rluB speG UB40_RS12920 suhB E: rne yidA alr β pfkB glucosidase: reductase: SixA: sixA cys gly -D-fructose 1,6- synthase phosphoribosyltransferase: apt UB40_RS08610 UB40_RS11280 RsmF: rsmF 2605 dehydratase: acnB glucosidase: ygjK N-acetyl-D-glucosamine UB40_RS00690 UB40_RS07115 1407 a pseudouridine N-(3-aminopropyl) chloramphenicol a [protein]- D-mannitol ile leu D-ala bisphosphate BioB: bioB a 5-methylcytosine myo-inositol an mRNA fragment pyruvate fatty acid 6-phosphate in 23S rRNA D-threo-isocitrate D-glucopyranose acetamide 3-acetate L-histidine oxidation in 16S rRNA D-galactopyranose a non galactosylated D-glucopyranose complex an unsulfurated AICAR D-glucopyranose + (indol-3-yl)acetate MeOH biotin 5'-deoxyadenosine met galactose acceptor 6-phosphate CoA-disulfide NADPH H subunit alpha [sulfur carrier] FadB: fadB (S)-3- superpathway of sulfate assimilation and cysteine biosynthesis Inorganic Nutrient Metabolism assimilatory DNA combined with 65 a [protein]- hydroxyhexanoyl-CoA selenate reduction dissimilatory sulfate assimilatory α β (R)-S- 3-decaprenyl-4- a uridine a double an aliphatic a phosphate D-sorbitol Reactive Blue 5 glycyl-glycine glutathione a (1->4)- -D-glucan p-nitrophenyl- -D-galactoside uroporphyrinogen-I a cytosine in DNA coniferaldehyde τ 3-hydroxyhexanoyl- reduction I (to sulfate reduction IV sulfate reduction III exogenous DNA to form lactoylglutathione hydroxybenzoate in tRNA stranded DNA α,ω-diamine N -phospho- monoester 6-phosphate 3-phospho-D-glycerate a recombinational junction L-histidine CoA hydrogen sufide)) Holliday junction 4-hydroxy-3- tRNA DNA cytosine coniferyl aldehyde DNA/RNA spermidine N1- alkaline sugar- sulfate selenate sulfate uroporphyrinogen phosphohistidine dehydrogenase: sulfate sulfate alpha-glucosidase: resolvase RuvX: ruvX beta-galactosidase polyprenylbenzoate pseudouridine(65) methyltransferase: dehydrogenase: nuclease acetyltransferase: phosphatase: phosphatase: phosphoglycerate sulfate sulfate Dyp-type gamma- hydroxyacylglutathione decarboxylase: hemE phosphatase fadJ sulfate sulfate UB40_RS04470 crossover junction subunit beta: decarboxylase: ubiD synthase TruC: truC UB40_RS08870 UB40_RS04650 SfsA: sfsA speG UB40_RS02285 yidA sulfate dehydrogenase: serA adenylyltransferase: adenylyltransferase: peroxidase: glutamyltransferase: ggt hydrolase: gloB SixA: sixA adenylyltransferase: adenylyltransferase: alpha-glucosidase: ygjK endodeoxyribonuclease UB40_RS08610 a pseudouridine 65 a 5-methylcytosine an aliphatic N- adenylyltransferase: adenosine 5'-cysN cysD cysN cysD UB40_RS11200 coproporphyrinogen I 2-decaprenylphenol ferulate a 5'-phosphooligonucleotide a [protein]- an alcohol D-sorbitol 3-oxohexanoyl-CoA cysN cysD cysN cysD RuvC: ruvC in tRNA in DNA acetyl-diamine cysN cysD 3-phosphooxypyruvate phosphoselenate APS APS resolution of recombinational L-histidine APS 3-[(4-amino-6-chloro- γ junction formation acetyl-CoA C- 3-phosphoserine/ 2,2'-disulfonyl -L-glutamyl- L-cysteinylglycine a (1->4)-α-D-glucan D-glucopyranose D-galactopyranose 4-nitrophenol (R)-lactate glutathione APS phosphoadenylyl- 1,3,5-triazin-2-yl) phthalate of two intact strands acetyltransferase: phosphohydroxythreonine adenylyl-sulfate azobenzene glycylglycine UB40_RS11400 kinase: cysC thiosulfate oxidation III (multienzyme complex) sulfate reductase: amino]benzenesulfonate adenylyl-sulfate transaminase: serC [+ 3 isozymes] UB40_RS17670 kinase: cysC selenite PAPS O-phospho-L-serine sulfite a [SoxY protein]-L-cysteine an (S-diacyl-sn- 1518 13 a [protein]- aldehydo-D- butanoyl-CoA sulfite an L-1- UDP-N-acetyl-α-D-muramoyl- D-alanyl-D-alanine a sialyloligosaccharide a uridine in tRNA D-threo-7,8- adenine / a 5' triphospho- a 4-hydroxy-3- a uridine oxaloacetate spermidine (2R,3S)-3- adenosyl-cob(III) D-glycerate PAPS phosphoadenylyl- glyceryl)-L-cysteinyl- 1519 N-phospho- galacturonate anaerobic phosphatidylethanolamine L-alanyl-γ-D-glutamyl-L-lysine dihydroneopterin adenine in 16S rRNA [mRNA] polyprenylbenzoate in tRNA isopropylmalate yrinate a,c-diamide acyl-CoA phosphoserine sulfate reductase: assimilatory sulfite [apolipoprotein] tRNA dihydrouridine(16) 16S rRNA RNA 4-hydroxy-3- tRNA spermidine N1- 3-isopropylmalate cobyric acid L-histidine glucuronate phosphoadenylyl- sulfite reductase citrate synthase: phosphohistidine glycerate kinase: dehydrogenase: phosphatase: serB UB40_RS17670 reductase (NADPH) synthase DusC: dusC (adenine(1518)-N(6)/ pyrophosphohydrolase: polyprenylbenzoate pseudouridine(13) acetyltransferase: dehydrogenase: synthase: isomerase: sulfate reductase: subunit AsrA: asrA UDP-N-acetylmuramoyl- exo-alpha-sialidase: UB40_RS00890 phosphatase UB40_RS07875 UB40_RS01735 selenodiglutathione flavoprotein subunit: apolipoprotein N- tRNA dihydrouridine dihydroneopterin adenine(1519)-N(6))- rppH decarboxylase: ubiD synthase TruD: truD speG leuB UB40_RS06405 uxaC UB40_RS17670 sulfite a [SoxY protein]-S- tripeptide--D-alanyl-D- UB40_RS06065 SixA: sixA a [DsrC]-trisulfide UB40_RS17680 acyltransferase: lnt synthase DusB: dusB aldolase: folB dimethyltransferase a 5'-phospho- a 2-(all-trans- a pseudouridine 13 1,2-dihydroxypropane- N 8 - 4-methyl-2- 2-phospho- acyl-CoA ser sulfosulfanyl-L-cysteine alanine ligase: murF adenosylcobyrate a [protein]- D-tagaturonate a 5,6-dihydrouridine in tRNA 6 RsmA: rsmA1518 dehydrogenase: sulfite hydrogen sulfide N -dimethyladenine [mRNA] polyprenyl)phenol in tRNA 1,2,3-tricarboxylate acetylspermidine oxopentanoate L-histidine D-glycerate cytochrome c: 6 1519 UB40_RS18100 serine acetyltransferase: a 2-acyl-1-lyso- an N-acyl-(S-diacyl- UDP-N-acetyl-α-D-muramoyl-L-alanyl- N-acetylneuraminate an oligosaccharide 6-(hydroxymethyl) /N -dimethyladenine assimilatory sulfite UB40_RS09755 glycolaldehyde UB40_RS16955 glutathioselenol phosphatidylethanolamine sn-glyceryl)-L- γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine -7,8-dihydropterin in 16S rRNA crotonyl-CoA reductase (NADPH) serine O- hydrogen sulfide [+ 2 isozymes] cysteinyl-[lipoprotein] flavoprotein subunit: acetyltransferase: cysE hydrogen sulfide (S)-3- UB40_RS17680 a [SoxY protein]-S- a [SoxY protein]-S an N 6 -L- UDP-N-acetyl- hydroxybutanoyl- disulfanyl-L-cysteine -sulfanyl-L-cysteine 3-methyl-2- 5,10-methylene- a 5-carboxymethylaminomethyluridine 34 a pseudouridine 1915 a 23S rRNA 3-heptaprenyl-4- 3-nonaprenyl-4- a uridine 55 CTP O-acetyl-L-serine 37 a uridine 38-40 in tRNA 2-phosphoglycolate α a thiopurine an aliphatic amine nitric oxide DHAP CoA hydrogen sulfide threonylcarbamoyladenine Leu 1911/1915/1917 -D-glucosamine hydrogen selenide oxobutanoate tetrahydromethanopterin in tRNA in 23S rRNA uridine hydroxybenzoate hydroxybenzoate in tRNA anaerobic hydratase: fadB 2-aminoethylphosphonate in tRNA RluA family pseudouridine tRNA (cytidine(34) 23S rRNA 23S rRNA UDP-N- urea cycle degradation I tRNA cyclic N6- 4-hydroxy-3- 4-hydroxy-3- tRNA phosphoglycolate acetylglucosamine thiopurine S- copper amine NO-inducible methylglyoxal ribonucleoside- (S)-3- synthase: UB40_RS04415 -2'-O)- (pseudouridine(1915)- pseudouridine(1911/ cysteine 3-methyl-2-oxobutanoate threonylcarbamoyladenosine(37) polyprenylbenzoate polyprenylbenzoate pseudouridine(55) phosphatase: 2-epimerase (non- methyltransferase: oxidase: flavohemoprotein: synthase: triphosphate hydroxybutanoyl-CoA tRNA pseudouridine(38- methyltransferase: N(3))-methyltransferase 1915/1917) synthase A: cysK (2-aminoethyl)phosphonate hydroxymethyltransferase: synthase TcdA: tcdA decarboxylase: ubiD decarboxylase: ubiD synthase TruB: truB UB40_RS19880 hydrolyzing): wecB UB40_RS18830 UB40_RS03815 hmpA UB40_RS06830 reductase: nrdD arg panB a cyclic N 6 -L- 40) synthase TruA: truA UB40_RS11635 3 RlmH: rlmH synthase RluD: rluD a pseudouridine 55 α a thiopurine (S)-3- a [SoxY protein]-S-(2- 2-aminoethylphosphonate- a 5-carboxymethylaminomethyl- an N - a pseudouridine 1911/ 2-heptaprenylphenol 2-nonaprenylphenol glycolate UDP-N-acetyl- - an aldehyde nitrate methylglyoxal dCTP thiosulfate a pseudouridine 38-40 in tRNA 1915 hydroxybutanoyl- sulfodisulfanyl)-L-cysteine -pyruvate threonylcarbamoyladenosine 34 Leu methylpseudouridine in tRNA D-mannosamine S-methylether disproportionation 2'-O-methyluridine in tRNA 1915/1917 in 23S rRNA CoA cys ammonium transaminase: phnW 37 in tRNA in 23S rRNA IV (rhodanese) dehydrogeanse: argininosuccinate phosphonoacetaldehyde 2-dehydropantoate THMPT fadJ thiosulfate lyase: argH glutamine- hydrolyzing phosphonoacetaldehyde acetoacetyl-CoA polyphosphate metabolism hydrolase: UB40_RS03935 34 α thiosulfate carbamoyl- 2,5-diamino-6-(5- phosphatidylglycerolphosphate a double a single 2'-deoxycytidine a cytidine in D-ribulose N-acetyl- - (2R,3S)-3- D-glucopyranose UTP L-arginino- dihydrolipoamide an N 10 -formyltetrahydrofolate putrescine a chitodextrin a sugar phosphate phosphate L-ornithine phosphate phospho-D-ribitylamino) met neuraminate acetyl-CoA C- sulfurtransferase: succinate long chain acetaldehyde (1-oleoyl, 2-palmitoyl) stranded DNA stranded DNA deoxynucleoside [elongator tRNA ] 5-phosphate isopropylmalate 6-phosphate anaerobic acyltransferase acquisition synthase: polyphosphate pyrimidin-4(3H)-one pyruvate oxygen-insensitive tRNA(Met) cytidine spermidine N1- N-acetylneuraminate 3-isopropylmalate chitinase: sugar- sugar- UB40_RS06790 bifunctional exodeoxyribonuclease deoxyribonuclease kinase: UB40_RS17510 phosphoribulokinase: ribonucleoside- FadA: fadA carA carB bifunctional acetaldehyde- phosphatidylglycerophosphatase dehydrogenase complex NAD(P)H-dependent acetyltransferase: acetyltransferase: epimerase: dehydratase: UB40_RS10740 phosphatase: phosphatase: a phosphate thiosulfate diaminohydroxyphosphoribosylaminopyrimidine V: recC recB recD IV: nfo deoxynucleoside UB40_RS19830 triphosphate [+ 3 isozymes] carbamoyl CoA/alcohol deaminase/5-amino-6-(5-phosphoribosylamino) A: pgpA dihydrolipoyllysine-residue nitroreductase NfsB: UB40_RS13050 speG UB40_RS09795 leuC leuD [+ 2 isozymes] yidA yidA monoester sulfurtransferase kinase: UB40_RS19000 β reductase: nrdD acid dehydrogenase: adhE acetyltransferase: aceF UB40_RS06000 4 34 D-ribulose-1,5- N-acetyl- - N,N'- GlpE: glpE argininosuccinate ornithine phosphate polyphosphate exopolyphosphatase: uracil reductase RibD: ribD 1-oleoyl-2-palmitoyl- a 5'-phosphooligonucleotide a 5'-phosphooligonucleotide dCMP an N -acetylcytidine N-acetylputrescine (2S)-2- a sugar D-glucopyranose dUTP acetyl-CoA phosphatase 5-amino-6-(5-phospho- 10 met neuraminate diacetylchitobiose synthase: kinase 1: ppk1 gppA phosphatidylglycerol S-acetyldihydrolipoamide an N -formyl-7,8-dihydrofolate in [elongator tRNA ] bisphosphate isopropylmalate AphA: aphA carbamoyltransferase: acetyl-CoA D-ribitylamino)uracil UB40_RS11495 UB40_RS13205 phosphate thiocyanate sulfite L-citrulline long chain polyphosphate a reduced a reduced cys plastocyanin an amino an amino an amino plastocyanin N-acetyl-α-D-galactosamine 1-phosphate a dicarboxylate a dicarboxylate a dicarboxylate putrescine an a purine glutathione an oxidized D-fructose a hexose 6- a sugar 6- (2-aminoethyl) acid acid acid cadaverine his a branched- an oxidized an L-sorbose 1-phosphate an L-sorbose 1-phosphate N-acetyl-α-D-galactosamine 1-phosphate putrescine putrescine a Coα-[α-(5,6- spermidine oligopeptide a basic plastocyanin 1-phosphate phosphate phosphate phosphonate an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino a peptide lys an inorganic glutamate D-glucose 6- D-fructopyranose 1-phosphate maltose 6'- a C4- chain plastocyanin D-fructose D-fructose D-fructose D-fructose D-fructose 1-phosphate D-fructose 1-phosphate D-fructose 1-phosphate ornithine ornithine phosphate phosphate phosphate phosphate phosphate glycine betaine pro a sugar 6- a sugar 6- met dimethylbenzimidazolyl) putrescine an a phospholipid homoserine lactone homoserine lactone histamine (S)-lactate amino acid 3-phenylpropanoate a nucleoside a nucleoside a nucleoside a carbohydrate a carbohydrate a lipopolysaccharide a lipopolysaccharide ammonium queuosine acid acid acid acid acid acid acid acid acid acid acid acid acid antibiotic pyrimidine anion phosphate D-fructofuranose 1-phosphate phosphate dicarboxylate amino acid 1-phosphate 1-phosphate 1-phosphate 1-phosphate D-mannose 6-phosphate D-mannose 6-phosphate D-mannose 6-phosphate phosphate sulfate sulfate pro phosphate phosphate ]-cobamide spermidine oligopeptide L-homoserine L-homoserine a polysaccharide a polysaccharide a polysaccharide a lipopolysaccharide a lipopolysaccharide predicted predicted predicted predicted predicted predicted predicted predicted predicted ABC ABC cytochrome- predicted ABC predicted ABC ABC ABC ABC ABC ABC cytochrome PEP-driven PEP-driven transporter of MlaF SbmA CadB RhtB RhtB RS17490 RS17715 RS02120 RS04130 GltS Crr RS17420 RS15785 DcuC BrnQ YfcC RS15895 transporter RS16935 RS02165 RS13805 c oxidase, RS18590 RS17205 RS11155 RS17415 RS17420 RS13090 RS13635 RS09870 RS09875 RS09880 PotE PotE RS04675 RS11285 efflux transporter of efflux transporter of LptA LptA RS05450 RS13305 RS10335 UhpT RS17180 PstB CysZ RS04885 RS11305 PutP RS09865 RS12430 RS07850 MetN RS18655 BtuD RS08605 RS09290 RS19190 RS09345 RS03875 transporter transporter transporter RS02255 RS12250 RS12260 RS12325 RS12335 RS17330 RS01425 RS07120 RS18995 transporter transporter OppF c oxidase transporter transporter (2-aminoethyl) of L-cysteine/ cbb3-type a lipopolysaccharide a lipopolysaccharide of an of an of an of spermidine/ of an of D-fructose of a sugar phosphonate glutathione amino acid amino acid amino acid putrescine oligopeptide D-fructopyranose a branched- L-sorbose N-acetyl-α-D-galactosamine N-acetyl-α-D-galactosamine a Coα-[α-(5,6- a peptide an inorganic D-glucose maltose a C4- a basic D-fructose D-fructose D-fructose D-fructose a carbohydrate a carbohydrate glycine betaine a sugar a sugar an amino an amino an amino an amino an amino an amino an amino an amino an amino an amino putrescine an a phospholipid homoserine lactone homoserine lactone pyrimidine (S)-lactate glutamate D-fructofuranose chain 3-phenylpropanoate a nucleoside a nucleoside a nucleoside D-fructose L-sorbose D-fructose phosphate phosphate phosphate phosphate pro ammonium met queuosine dimethylbenzimidazolyl) antibiotic histamine anion dicarboxylate amino acid a polysaccharide a polysaccharide a polysaccharide a lipopolysaccharide a lipopolysaccharide phosphate phosphate sulfate sulfate pro acid acid acid acid acid acid acid acid acid acid an amino an amino an amino spermidine oligopeptide lys L-homoserine L-homoserine amino acid O D-fructose D-mannose D-fructose D-mannose ornithine ornithine a hexose 6- a sugar (2-aminoethyl) ]-cobamide O 2 a lipopolysaccharide a lipopolysaccharide acid acid acid putrescine an cadaverine cys 2 putrescine putrescine phosphonate an amino an amino an amino a purine his H O D-mannose phosphate spermidine oligopeptide glutathione H O 2 acid acid acid a dicarboxylate a dicarboxylate a dicarboxylate 2 This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.