Publications 2002 Agarwal, R., Peters, T.J., Coombes, R.C., Vigushin, D.M. Tamoaxifen-related porphyria cutanea tarda. Medical Oncology. 19, 121-124 (2002) Anderson GJ, Frazer DM, McKie AT, Vulpe CD. The homolog and the control of intestinal iron absorption. Blood Cells Mol Dis. 2002 Nov-Dec;29(3):367-75. Anderson GJ, Frazer DM, Wilkins SJ, Becker EM, Millard KN, Murphy TL, McKie AT, Vulpe CD. Relationship between intestinal iron-transporter expression, hepatic levels and the control of iron absorption. Biochem Soc Trans. 2002 Aug;30(4):724-6. Anderson GJ, Frazer DM, McKie AT, Wilkins SJ, Vulpe CD. The expression and regulation of the iron transport molecules hephaestin and IREG1: implications for the control of iron export from the small intestine. Cell Biochem Biophys. 2002;36(2- 3):137-46. Review. Cremonesi, P., Acebron, A., Raja, K.B., & Simpson, R.J. Iron absorption: Biochemical and molecular insights into the importance of iron species for intestinal uptake. Pharmacol Toxicol, 91, 97-102 (2002) Desouky M, Jugdaohsingh R, McCrohan CR, White KN, Powell JJ. Aluminium- Dependent Regulation of Intracellular Silicon in the Aquatic Invertebrate Lymnaea stagnalis Proc. Natl. Acad. Sci. 2002;99:3394-3399. Evans RW, Hider RC & Wrigglesworth JM. (2002). Biometals 2002: Third International Biometals Symposium, Biochemical Society Transactions 30, 669-783. Evans, R.W.& Oakhill, J.S. (2002) -mediated iron acquisition by pathogenic Neisseria. Biochemical Society, 30, 705-707. Frazer DM, Wilkins SJ, Becker EM, Vulpe CD, McKie AT, Trinder D, Anderson GJ. Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology. 2002 Sep;123(3):835-44. Hider, R.C., Co-Editor, European Journal of Clinical Investigation, 32 S1 Including the following articles • Rooyakkers, T.M., Stroes, E.S.G., Kooistra, M.P., van Faassen, E.F., Hider, R.C., Rabelink, T.J., Marx, J.J. Ferric saccharate induces oxygen radical stress and endothelial dysfunction in vitro. 9-16. (2002) • Kooistra, M.P., Kerstring, S., Gosriwatana I, Lu, S., Nijhoff-Schutt, J., Hider, R.C. & Marx, J.J.M. Nontransferrin-bound iron in the plasma of haemodialysis patients, after intravenous iron saccharate infusion 36-41 (2002) • Hider, R.C. Nature of nontransferrin-bound iron. 50-54 (2002). • Georgiou, N.A., Van der Beuggen, T., Oudshoorn, M., Hider, R.C., Marx, J.J, & von Asbeck, B.S. Human immunodeficiency virus type I replication inhibition by the bidentate iron chelators CP502 & CP511 is caused by proliferation inhibition and the onset of apoptosis. 91-98. (2002) Jugdaohsingh R, Anderson SHC, Tucker KL, Elliott H, Kiel DP, Thompson RPH, and Powell J.J. Dietary silicon intake and bioavailability. Am. J. Clin. Nutr. 2002;75:887- 893. Kuser, P., Haw, M.L., Neu, M., Evans, R.W., Lindley, P.P. The mechanism of iron uptake by : the x-ray structures of the 18kDa N-II domain fragment of duck ovotransferrin and its nitrilotriacetate complex. Acta Cryst,D58, 777-783. Ladhani, S., Cameron, J., Chapple, D.S., Garratt, R.C., Joannou, C.L. & Evans, R.W. (2002). A novel method for rapid production and purification of exfoliative toxin A of Staphyloccus aureus. FEMS Microbiology Letters, 212, 35-39. Latunde-dada, G.O., Van der Westhuizen, J.P., Vulpe, C.D., Anderson, G., Simpson, R.J. and Mckie, A.T. Molecular and functional roles of duodenal cytochrome B (Dcytb) in iron . Blood Cells Mol. Dis. 29, 356-360 (2002). Latunde-Dada GO, Van der Westhuizen J, Vulpe CD, Anderson GJ, Simpson RJ, McKie AT. Molecular and functional roles of duodenal cytochrome B (dcytb) in iron metabolism. Blood Cells Mol Dis. 2002 Nov-Dec;29(3):356-60. Lebeau, A., Frank, J., Biesalski, H.K., Weiss, G., Srai, S.K., Simpson, R.J., Mckie, A.T., Habram, S., Gilfillan, S. & Schumann, K. Long-term sequels of HFE deletion in C57BL/6 x 129/O1a mice, an animal model for hereditary hemochromatosis. Eur J Clin Invest, 32, 603-612 (2002) Lomer MCE, Thompson RPH and Powell JJ. Fine and Ultrafine Particles of the diet: infleuence on the mucosal iummmune response and association with Crohn's disease. Proc. Nutr. Soc.2002;61:123-130. Loreal, O., Turlin, B., Pigeon, C, Moisan, A., Ropert, M., Morice, P., Gando, Y., Jouanolle, A., Verin, M., Hider, R.C., Yoshida, K., Brissot, P. Aceruloplasminemia: new clinical, pathophysiological and theapeutic insights. Journal of Hepatology, 36, 851-856 (2000). Lui, Z.D & Hider, R.C. Design of Clinically useful Iron(III)-Selective Chelators. Medicinal Research Reviews, 22, 26-64 (2002) Lui, Z.D., Hider, R.C. Design of iron chelators with therapeutic application. Coordination Chemistry Review, 232, 151-171 (2002) Liu DY, Liu ZD, Hider RC. Oral iron chelators--development and application. Best Pract Res Clin Haematol.15(2):369-84. 2002 Liu, D.Y., Liu, Z.D., Piyamongkol, S., Lu, S.L., & Hider, R.C. Characerization of two isomeric ß-D-glucosiduronic acids derived from 1,2-dimethyl-3-hydroxypyridin-4-one (CP94) in rat liver homogenate incubates. Journal of Pharmacy & Pharmacology, 54, 951-957 (2002) Liu, Z.D. & Hider, R.C. Chapter 13, Iron Chelator Chemistry, Molecular and Cellular Iron Transport, p321-357. Edited by D.M.Templeton, Marcel Deaker Inc. 2002. Lui, Z.D., Kayyali, R., Hider, R.C., Porter, J.B. & Theobald, A.E. Design, Synthesis, and Evaluation of Novel 2-Substituted 3-Hydroxypridin-4-ones. Structure-Activity Investigation of Metalloenzyme Inhibition by Iron Chelators. J Med.Chem, 45, 631- 639, 2002. Mckie, A.T. and Simpson, R.J. Basolateral transport of iron in mammalian intestine: from physiology to molecules. In 'Molecular and Cellular Iron Transport' Marcel Dekker Inc, New York pp175-188 (2002). Mckie, A.T., Latunde-Dada, G.O., Miret, S., McGregor, J.A., Anderson, G.J., Vulpe, C.D. and Simpson, R.J. Molecular Evidence for the Role of a Ferric Reductase in Iron Transport. Biochem. Soc. Trans. 30, 722-724 (2002). Moridani, M.Y., Tilbrook, G.S., Khodr, H.H., & Hider, R.C. Synthesis and physicochemical assessment of novel 2-substituted 3-hydroxpyridin-4-ones, novel iron chelators. Journal of Pharmacy & Pharmacology, 54. 349-364. 2002 Müller, A., Tscherny, I., Kappl, R., Hatchikian, E.C., Hüttermann, J. and Cammack, R. Hydrogenases in the ‘Active’ State: Determination of g-Matrix Axes and Electron Spin Distribution at the Active Site by Orientationally Selective 1H ENDOR Spectroscopy. Journal of Biological Inorganic Chemistry, 7. 177-194. (2002) Neubert, H., Hider, R.C., & Cowan, D.A. Speciation of Fe (III)-chelate complexes by electrospray ionization ion and laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry. Rapid Communications in Mass Spectrometry. 16, 1556-1561. (2002) Oakhill, J. S., Joannou, C.I., Buchanan, S.K., Gorringe, A.R.& Evans, R.W. (2002) Expression and purification of functional recombinant meningococcal transferrin- binding protein A Biochemical Journal, 354, 613-616. Powell J.J. Analysis of Aluminosilicate Particles in Biological Matrices using Histochemistry and X-ray Microanalysis. The Analyst. 2002:127(6); 842 – 846 Rayman, M.P., Barlis, J., Evans, R.W., Redman, C.W.G. & King, I.J. Abnormal iron parameters in the pregnancy syndrome pre-eclampsia. American Journal of Obstetrics and Gynaecology, 187, 412-418. Syed, B.A., Beaumont, N.J., Patel, A., Naylor, C.E., Baylee, H.K., Joannou, C.L., Rowe, P.S.N., Evans, R.W. & Srai, S.K.S. Analysis of the human hephaestin and protein: comparative modelling of the N-terminus, ecto-domain based upon ceruloplasin. Protein Eng, 15, 205-214, 2002 Winkler AS, Marsden J, Deacon A, Wilson S, Chandler G, Macdougall IC, Peters TJ (2002) Serum erythropoietin levels may be inappropriately low in the acute neuropsychiatric porphyrias.Clin Chim Acta 317: 93-100 Zanninelli, G., Loreal, O., Brissot, P., Konijn, M., Slotki, I.N., Hider, R.C. & Cabantchik, Z.I. The labile iron pool of hepatocytes in chronic and acute iron overload and chelator iron deprivation. Journal of Hepatology, 36, 29-46 (2002)