Prof. Dr. Horst Domdey

Contact details BioM Biotech Cluster Development GmbH Am Klopferspitz 19 a, 82152 Martinsried/, tel: +49 89 899679-11 e-mail: [email protected] ______

PROFESSIONAL EXPERIENCE Since 2006 Chief Executive Officer of BioM Biotech Cluster Development GmbH, Martinsried, Germany. BioM GmbH is a spin-off of BioM AG focussing exclusively on cluster development, technology transfer, start-up support, advisory and industry sector support activities 2001-2012 Management Partner of the BioM Venture Capital GmbH & Co. Fonds KG Since 1998 Honorary Professor at the Faculty for Chemistry and Pharmacy of the Ludwig Maximilian University Munich Since 1998 Chief Executive Officer and since 2017 Liquidator of BioM AG Munich Biotech Development, Martinsried, Germany. Creation and establishment of BioM as a tech-transfer, advisory and seed capital organ which has played a major role in the successful development of the Munich Biotech Cluster. 1994-1998 Professor for Biochemistry at the Institute of Biochemistry of the Ludwig Maximilian University Munich Successful management of the Munich Biotech Initiative that made Munich one of the three winners of the German BioRegio contest in 1996 1984-1993 Group leader and research associate at the Gene Center of the Ludwig Maximilian University Munich 1983-1984 Postdoctoral fellow at the California Institute of Technology, Pasadena, USA 1982-1983 Postdoctoral fellow at the University of California, San Diego, La Jolla, USA 1982 Postdoctoral fellow at the Max Planck Institute of Biochemistry, Martinsried, Germany 1980-1982 Postdoctoral fellow at the Swiss Institute for Experimental Cancer Research (ISREC), Epalinges, Switzerland 1979-1980 Postdoctoral fellow at the Max Planck Institute of Biochemistry, Martinsried, Germany

EDUCATION 1976-1979 Doctoral thesis at the Max Planck Institute of Biochemistry, Martinsried: Determination and analysis of the complete structure of the plant pathogen viroid RNA 1970-1975 Studies in chemistry and biology at the Friedrich-Alexander University Erlangen, Germany. Final exam (MA-equivalent) passed with honours.

Prof. Dr. Horst Domdey

FURTHER ACTIVITIES AND ACHIEVEMENTS 1988-1990 Member of several committees in the European Human Genome Analysis Program 1993-2009 Member of the Board of Directors of the German Society for the Promotion of Biomedical Research e.V. 1994 Cofounder of Medigene AG 1997 Cofounder of Switch Biotech AG 1997-2017 Member in the Supervisory Boards of 19 biotech companies 1998-2008 Management of two life science incubators in Martinsried and Weihenstephan Since 2000 Member of the Juries of the Munich Business Plan Competition and the North Bavarian Business Plan Competition 2001-2016 Member of the Committee for Industry and Research of the Association of the German Chambers of Industry and Commerce 2002-2003 Chairman of the International Life Science Forum e.V. 2003-2015 Member of the Jury of the European Biotechnica Award 2003-2018 Chairman of the Bavarian Genome Research Network "BayGene" 2004-2006 Co-Founder and Chairman of the Steering Committee of the German BioRegions 2004-2013 Co-Founder and Member of the Board of Directors of BIO Deutschland (German Biotechnology Industry Association) 2004-2011 Co-Founder and Member of the Steering Committee of the Council of the European BioRegions (CEBR) 2005-2010 Member of the working group for interim evaluations of the "Super COE" programs of the Japanese Ministry of Education, Culture, Sports, Science and Technology 2006-2011 Member of the Plenum of the Munich Chamber of Industry and Commerce Since 2006 Chairman of the Bavarian Biotech Cluster 2007-2008 Consulting for King Abdulaziz University Jeddah to create and establish a local Biotech Cluster 2009-2010 Member of the Biotechnology Initiative of the Secretary General of the United Nations 2010-2015 Chairman of Munich’s Leading Edge Cluster Program “m4 – Personalized Medicine” 2011-2016 Member of the Supervisory Board of Oasmia Pharmaceutical AB, Uppsala, Sweden 2012-2018 Coordinator of the Bavarian Research Network for Molecular Biosystems "BioSysNet" 2013-2020 Member of the Supervisory Board of Medigene AG, Martinsried Since 2013 Member of the External Advisory Board of the Interdisciplinary Bank of Biomaterials and Data Würzburg Since 2013 Member of the Steering Committee of the Bavarian Business Advisory Board 2014-2018 Member of the International Advisory Committee of the Thailand Center of Excellence for Life Sciences (TCELS) 2016-2018 Member of the Advisory Board of Health Industries South Australia 2016-2020 Member of the Supervisory Board of the Max Delbrück Center for Molecular Medicine Since 2016 Member of the Executive Board of the Peter and Traudl Engelhorn Foundation for the Advancement of Life Sciences Since 2017 Member of the Advisory Board of BIOTOPIA Naturkundemuseum Bayern Since 2017 Member of the Executive Board of the Stiftung für Stammzellenforschung und angewandte regenerative Medizin – StemCellRegMed Foundation 2019-2021 Member of the Advisory Board of GNA Biosolutions Since 2019 Member of the Advisory Board of FCF – Fox Corporate Finance Since 2019 Member of the Translational Research Group of the German Centre for Cardiovascular Research Since 2019 Chairman and coordinator of the Bavarian Research Network on “New strategies against multi-resistant pathogens by means of digital networking – bayresq.net” 2/3

Prof. Dr. Horst Domdey

AWARDS Research fellowship from the Studienstiftung des Deutschen Volkes / German Academic Scholarship Foundation (1977-1979) Research fellowship from the Deutsche Forschungsgemeinschaft / German Research Foundation (1981-1982) Research fellowship from the European Molecular Biology Organization (1983) Medal of State for Outstanding Contributions to the Bavarian Economy (2013) “Pro meritis scientiae et litterarum” award of the Bavarian State Ministry for Science and Art (2019)

SELECTED PUBLICATIONS FROM SCIENTIFIC CARREER (10 out of 108) 1. Gross, H.J., Domdey, H., Lossow, C., Jank, P., Raba, M., Alberty, H. and Sänger, H.L. (1978). Nucleotide sequence and secondary structure of Potato Spindle Tuber Viroid. Nature 273, 203-208. 2. Konarska, M., Filipowicz, W., Domdey, H. and Gross, H.J. (1981). Formation of a 2'- phosphomonoester, 3', 5'-phosphodiester linkage by a novel RNA ligase in wheat germ. Nature 293, 112-116. 3. Domdey, H., Wiebauer, K., Kazmaier, M., Müller, V., Odink, K. and Fey, G. (1982). Characterization of the mRNA and cloned cDNA specifying the third component of mouse complement. Proc. Natl. Acad. Sci. USA 79, 7619-7623. 4. Domdey, H., Apostol, B., Lin, R.-J., Brody, E. and Abelson, J. (1984). Lariat structures are in vivo intermediates in yeast pre-mRNA splicing. Cell 39, 611-621. 5. Ng, R., Domdey, H., Larson, G., Rossi, J.J. and Abelson, J. (1985). A test for intron function in the yeast actin gene. Nature 314, 183-184. 6. Köhrer, K., Vogel, K. and Domdey, H. (1990). A yeast tRNA-precursor containing a pre- mRNA intron is spliced via the pre-mRNA splicing mechanism. EMBO J. 9, 705-709. 7. zu Putlitz, J., Kubasek, W.L., Duchêne, M., Marget, M., von Specht, B.-U. and Domdey, H. (1990). Antibody production in Baculovirus-infected insect cells. BioTechnology 8, 651-654. 8. Dujon, B., …, Domdey, H., et al. (1994). Complete DNA sequence of yeast chromosome XI. Nature 369, 371-378. 9. Specht, B.-U., Knapp, B., Muth, G., Bröker, M., Hungerer, K.-D., Diehl, K.-D., Massarrat, K., Seemann, A. and Domdey, H. (1995). Protection of immunocompromised mice against lethal infection with Pseudomonas aeruginosa by active or passive immunization with recombinant P. aeruginosa outer membrane protein F and outer membrane protein I fusion proteins. Infect. Immun. 63, 1855-62. 10. Stumpf, G. and Domdey, H. (1996). Dependence of yeast pre-mRNA 3'-end processing on CTF1: a sequence homolog of the mammalian AAUAAA-binding factor. Science, 274, 1517- 1520.

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