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Use of Nitrous Oxide for Pediatric Dental Patients

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Use of Nitrous Oxide for Pediatric Dental Patients BEST PRACTICES: USE OF NITROUS OXIDE Use of Nitrous Oxide for Pediatric Dental Patients Latest Revision How to Cite: American Academy of Pediatric Dentistry. Use of 2018 nitrous oxide for pediatric dental patients. The Reference Manual of Pediatric Dentistry. Chicago, Ill.: American Academy of Pediatric Dentistry; 2020:324-9. Purpose return to preprocedure mobility. In children, analgesia/ The American Academy of Pediatric Dentistry (AAPD) anxiolysis may expedite the delivery of procedures that are recognizes nitrous oxide/oxygen inhalation as a safe and not particularly uncomfortable, but require that the patient effective technique to reduce anxiety, produce analgesia, and not move.3 It also may allow the patient to tolerate unpleas- enhance effective communication between a patient and health ant procedures by reducing or relieving anxiety, discomfort, care provider. The need to diagnose and treat, as well as the or pain. Furthermore, it increases reaction time and reduces safety of the patient and practitioner, should be considered pressure-induced pain, but does not affect pulpal sensitivity, before using nitrous oxide. By producing this guideline, the as shown in a double blind, crossover study.5 AAPD intends to assist the dental profession in developing Nitrous oxide is a colorless and virtually odorless gas with appropriate practices in the use of nitrous oxide/oxygen a faint, sweet smell. It is an effective analgesic/anxiolytic agent analgesia/anxiolysis for pediatric patients. causing central nervous system (CNS) depression and euphoria with little effect on the respiratory system.6,7 Nitrous oxide has Methods multiple mechanisms of action. The analgesic effect of nitrous These recommendations were developed by the Council on oxide appears to be initiated by neuronal release of endoge- Clinical Affairs and adopted in 2005. This document is a nous opioid peptides with subsequent activation of opioid revision of the previous version, last revised in 2013. The receptors and descending gamma-aminobutyric acid type A revision is based on a review of the current dental and medical (GABAA) receptors and noradrenergic pathways that modu- literature related to nitrous oxide use. A search was conducted late nociceptive processing at the spinal level. The anxiolytic using the database of PubMed®/MEDLINE with the effect involves activation of the GABAA receptor either directly parameters: nitrous oxide [Mesh] OR nitrous oxide reductase or indirectly through the benzodiazepine binding site.8,9 [Supplementary Concept], publication date from January 1, Nitrous oxide has rapid uptake, being absorbed quickly from 2012; humans; child: birth-18 years. Thirty-nine articles met the alveoli and held in a simple solution in the serum. It is these criteria, and applicable articles were chosen and added relatively insoluble, passing down a gradient into other tissues to the references from the previous document. Additionally, and cells in the body, such as the CNS. It is excreted quickly the American Dental Association’s Guideline for the Use of from the lungs. Nitrous oxide causes minor depression in Sedation and General Anesthesia by Dentists1 and the American cardiac output while peripheral resistance is slightly increased, Dental Association’s Oral Health Topics – Nitrous Oxide Dental thereby maintaining the blood pressure.5 This is of particular Best Practices for Nitrous Oxide-Oxygen Use 2 were reviewed. advantage in treating patients with cerebrovascular system When data did not appear sufficient or were inconclusive, disorders. recommendations were based upon expert and/or consensus Nitrous oxide is absorbed rapidly, allowing for both rapid opinion by experienced researchers and clinicians. onset and recovery (two to three minutes). It causes minimal impairment of any reflexes, thus protecting the cough reflex.6 Background It exhibits a superior safety profile with no recorded fatalities Dentists have expertise in providing anxiety and pain control or cases of serious morbidity when used within recommended for their patients. While anxiety and pain can be modified by concentrations.10-13 psychological techniques, in many instances pharmacological The decision to use nitrous oxide/oxygen analgesia/anxiolysis approaches are required.1 The outcome of pharmacological ap- must take into consideration alternative behavioral guidance proaches is variable and depends upon each patient’s response modalities, the patient’s dental needs, the effect on the quality to various drugs. The clinical effect of nitrous oxide/oxygen of dental care, the patient’s emotional development, and the inhalation, however, is more predictable among the majority patient’s physical considerations. Nitrous oxide generally is of the population. When used for analgesia/anxiolysis, nitrous oxide/oxygen inhalation allows for diminution or elimination ABBREVIATIONS of pain and anxiety in a conscious patient, while entailing AAPD: American Academy Pediatric Dentistry. CNS: Central nervous minimum risk.3 The patient responds normally to verbal system. GABAA: Gamma-aminobutyric acid type A. L/min: Liters 4 commands. All vital signs are stable, there is no significant per minute. risk of losing protective reflexes, and the patient is able to 324 THE REFERENCE MANUAL OF PEDIATRIC DENTISTRY BEST PRACTICES: USE OF NITROUS OXIDE acceptable to children and can be titrated easily. Most children 2. current medications including dose, time, route, and are enthusiastic about the administration of nitrous oxide/ site of administration. oxygen; many children report feeling a tingling or warm 3. diseases, disorders, or physical abnormalities and sensation.14 Objectively, children may appear with their hands pregnancy status. open, legs limp, and a trancelike expression.14 For some pa- 4. previous hospitalization to include the date and tients, however, the feeling of losing control may be troubling, purpose. and children with claustrophobia may find the nasal hood 5. recent illnesses (e.g., cold or congestion) that may confining and unpleasant.15 compromise the airway. Nitrous oxide has been associated with bioenvironmental concerns because of its contribution to the greenhouse effect.16 Contraindications for use of nitrous oxide/oxygen inhalation Nitrous oxide is emitted naturally by bacteria in soils and may include: oceans; it is produced by humans through the burning of 1. some chronic obstructive pulmonary diseases.19 fossil fuels and forests and the agricultural practices of soil 2. current upper respiratory tract infections.20 cultivation and nitrogen fertilization. Altogether, nitrous oxide 3. recent middle ear disturbance/surgery.20 contributes about five percent to the greenhouse effect.17,18 4. severe emotional disturbances or drug-related de- However, only a small fraction of the total nitrous released into pendencies.20 the atmosphere (0.35 to two percent) is actually the result of 5. first trimester of pregnancy.21 medical applications of nitrous oxide gas.18 6. treatment with bleomycin sulfate.22 7. methylenetetrahydrofolate reductase deficiency.23 The objectives of nitrous oxide/oxygen inhalation include: 8. cobalamin (vitamin B12) deficiency.9 1. reduce or eliminate anxiety. 2. reduce untoward movement and reaction to dental Whenever possible, appropriate medical specialists should treatment. be consulted before administering analgesic/anxiolytic agents 3. enhance communication and patient cooperation. to patients with significant underlying medical conditions 4. raise the pain reaction threshold. (e.g., severe obstructive pulmonary disease, congestive heart 5. increase tolerance for longer appointments. failure, sickle cell disease24, acute otitis media, recent tympanic 6. aid in treatment of the mentally/physically disabled membrane graft25, acute severe head injury26). In addition, or medically compromised patient. consultation with the prenatal medical provider should pre- 7. reduce gagging. cede use of nitrous oxide/oxygen analgesia/anxiolysis during 8. potentiate the effect of sedatives. pregnancy.27 Disadvantages of nitrous oxide/oxygen inhalation may include:6 Technique of nitrous oxide/oxygen administration 1. lack of potency. Nitrous oxide/oxygen must be administered only by appro- 2. dependant largely on psychological reassurance. priately licensed individuals, or under the direct supervision 3. interference of the nasal hood with injection to an- thereof, according to state law. The practitioner responsible for terior maxillary region. the treatment of the patient and/or the administration of 4. patient must be able to breathe through the nose. analgesic/anxiolytic agents must be trained in the use of such 5. nitrous oxide pollution and potential occupational agents and techniques and appropriate emergency response. exposure health hazards. Selection of an appropriately sized nasal hood should be made. A flow rate of five to six litres per minute (L/min) Recommendations generally is acceptable to most patients. The flow rate can Indications for use of nitrous oxide/oxygen analgesia/anxiolysis be adjusted after observation of the reservoir bag. The bag include: should pulsate gently with each breath and should not 1. a fearful, anxious, or obstreperous patient. be either over- or underinflated. Introduction of 100 percent 2. certain patients with special health care needs. oxygen for one to two minutes followed by titration of ni- 3. a patient whose gag reflex interferes with dental care. trous oxide in 10 percent intervals is recommended. During 4.
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