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(12) Patent Application Publication (10) Pub. No.: US 2014/0302163 A1 Sanchez Et Al

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US 20140302163A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2014/0302163 A1 Sanchez et al. (43) Pub. Date: Oct. 9, 2014 (54) WATER WITH IMPROVED TRANSDERMAL A613 L/714 (2006.01) AND CELLULAR DELIVERY PROPERTIES A 6LX3/59 (2006.01) AND METHODS OF MANUFACTURE AND A 6LX3/593 (2006.01) USE THEREOF A2.3L 2/52 (2006.01) A63/94 (2006.01) (71) Applicant: Subtech Industries, LLC, Stuart, FL (52) U.S. Cl. (US) CPC. A23L I/293 (2013.01); A23L 2/52 (2013.01); C02F I/30 (2013.01); A61 K33/00 (2013.01); (72) Inventors: David Sanchez, Port Saint Lucie, FL A6 IK3I/194 (2013.01); A61 K3I/714 (US); Len Deweerdt, Port Saint Lucie, (2013.01); A61 K3I/519 (2013.01); A61 K FL (US) 31/593 (2013.01); A61K 36/02 (2013.01) USPC ................. 424/600; 426/2: 426/66; 210/251: (73) Assignee: Subtech Industries, LLC, Stuart, FL 210/198.1; 210/201; 210/202: 514/569; 514/52: (US) 424/195.17; 514/789 (21) Appl. No.: 14/214,945 (57) ABSTRACT 1-1. A process for preparing conventional water sources for pro (22) Filed: Mar 16, 2014 viding “ideal state' cellular wellness benefits via topical Related U.S. Application Data hydrationabsorption. and The natural invention’s transdermal, process considersepithelial preconditioned O epicellular (60) Provisional application No. 61/788,206, filed on Mar. water sources that have removed solids, dissolved solids, 15, 2013. contaminants—both organic and inorganic and Subsequently the method purifies the water respective of removing patho Publication Classification gens, and structures the water for cellular uptake in the form of vicinal grade water, with improved characteristics of ideal (51) Int. Cl. frequency, cluster size, pH, before safely introducing nega A2.3L I/29 (2006.01) tive ORP (highly ionized state) to the water structure and CO2F I/30 (2006.01) organic nutrients or other Supplemental pharmaceutical grade A6 IK33/00 (2006.01) organic materials onto the skin or epithelial/epicellular envi A6 IK36/02 (2006.01) ronments Surrounding tissue and cells. Patent Application Publication Oct. 9, 2014 Sheet 1 of 4 US 2014/0302163 A1 ----------------- ***** ºg; ********** 3×3×3×3 :--------- §§§. ***g $3 3×3×3×3 333333 Patent Application Publication Oct. 9, 2014 Sheet 2 of 4 US 2014/0302163 A1 Patent Application Publication Oct. 9, 2014 Sheet 3 of 4 US 2014/0302163 A1 Patent Application Publication Oct. 9, 2014 Sheet 4 of 4 US 2014/0302163 A1 wae $$$$$$$$$$$$$$ ::: X. X. 8: xix. 8:3 s & s.s. is 8 & 8 & 8 x w w w x - c. x. US 2014/0302163 A1 Oct. 9, 2014 WATER WITH IMPROVED TRANSIDERMAL (0011 JP 20044285036 for Skin Conditioning Agent to AND CELLULAR DELVERY PROPERTIES Hiroshima Kasei. This application teaches a skin condition AND METHODS OF MANUFACTURE AND ing agent which is produced electrolytically containing a USE THEREOF reduced water having a neutral pH and a negative 400 redox. 0012 JP 2006096667 and U.S. Pat. No. 5,776,346 teach INCORPORATION BY REFERENCE AND that water produced by ion exchange resins including tour CLAIM OF PRIORITY maline and aluminum oxide having negative oxidation reduc tion potential is ingestible to lower blood Sugar. 0001. This application claims priority to U.S. provisional 0013 JP2006326374 teaches the use of electrodes to patent application No. 61/788.206 filed on Mar. 15, 2013, the modify the redox potential of water along with use of tour contents of which are expressly incorporated by reference. maline. The contents of all references cited herein are expressly incor (0014) JP2003335655A2 discloses a mineral water gener porated in their entirety. ated by passing natural water through a column that includes tourmaline. No values appear to be given for redox. BACKGROUND OF THE INVENTION (0015 US 200401 18775 A1 teaches the use of bubbling 0002 Water is ubiquitous in biology and plays roles which hydrogen gas through water to produce a product with a ph are well known and many which we do not fully appreciate. from 6.5-9 and redox values from -150 to -900. Water plays a primary role in biology for solubilizing and 0016 U.S. Pat. No. 5,880,048 A for Granular Ceramic for transporting molecules required to maintain life. The art pri Water Deoxidation and method of Producing the same Sato: marily teaches ingestion of water solubilized molecules to KaZuo et al. meet nutritional or therapeutic needs. (0017 KR100.647036B1 for Filter for Generating Alkaline 0003 Water is universally recognized as a good solvent for Reduced Water and Apparatus Using the Same to Jeon charged and polar solvents and a poor solvent for hydrocar Hyoung Tag. This patent discloses the use of ORP balls but bons. does not appear to reach the negative redox levels you achieve. (no English language version available) 0004. The art has recognized that intracellular water, 0018 US20120213756A1 teaches the use of oral fulvic water located within cells, appears to be different than water acid to Scavenge free radicals and transport nutrients. It does as we generally know it in normal bulk phase. Phillipa Wig not teach transdermal use. gins, Role of Water in Some Biological Processes, Microbio 0019 US2006/7067155 Anti-inflammatory humate com logical Reviews. Vol 54 (4) p432-449 (1990). In fact, there positions and methods of use thereof teaches the use of appears to be 3 forms of water, water which is bound to humates and fulvics as Supplementation that can reduce Surfaces, vicinal water associate with Surfaces but not bound inflammation. to them and ordinary aqueous water. Each of these three 0020 Phytochemicals and micronutrients sourced from forms has different properties. plants are now known to impact gene expression in animals 0005. In recent years the literature has given greater atten according to recent studies. Cell Research 22:3-5, doi:1038/ tion to vicinal water and its role in cellular function. cr.2011. 164; published online October 2011 article entitled 0006. Many enzymatic reactions are oxidation-reduction “Ingested plant miRNAS regulate gene expression in ani reactions in which one compound is oxidized and another mals' clearly showed phenotypical changes related to pro compound is reduced. The ability of an organism to carry out teomic influences in animals tested. oxidation-reduction reactions depends on the oxidation-re (0021 US2010/0092399 A1 for Methods of Treating or duction state of the environment, or its reduction potential. Preventing Inflammation and Hypersensitivity with Oxida 0007. In aqueous solutions, the reduction potential is a tive Reduction Potential Water Solution to Hojabr Alimi. This measure of the tendency of the Solution to either gain or lose published patent application teaches the use of high positive electrons when it is Subject to change by introduction of a new ORP water generated electrolytically. species. A Solution with a higher (more positive) reduction (0022 US2010/0316776 for Compositions and Methods potential than the new species will have a tendency to gain for Producing Stable Negative ORP in Consumable Materials electrons from the new species (i.e. to be reduced by oxidiz to Dusan Miljkovic. This published patent application ing the new species) and a solution with a lower (more nega teaches using reducing compounds to generate high negative tive) reduction potential will have a tendency to lose electrons ORP water. KHCO3 is primarily used and ascorbic acid used to the new species (i.e. to be oxidized by reducing the new to adjust pH. species). Oxidation Reduction Potential (“ORP) is generally 0023 US 2006/0275498 for Processed Water and Thera measured by means of a electrode. Redox meters are well peutic Uses Thereof to David Bagley discloses the use of known in the art. electrolytically obtained negative ORP water to treat condi 0008. However, internal delivery of molecules is not tions. always efficient or even effective due to the many mecha 0024 U.S. Pat. Nos. 5,711,950 and 6,033,678 teach the nisms the body has to prevent contamination including but preparation of microclustered water using steam, magnetic not limited to filtering by liver and kidneys and active pumps fields and far infra-red to ultraviolet spectrum range light. present in the gut such as p glycoprotein. (0025 U.S. Pat. No. 7,291.314 for Activated water appara 0009. The art has tried to create ways to improve the prop tus and methods teaches a structured water having an ORP erties of water for various biological purposes. Various below -350 and a cluster size below 4 and a pH below 4 or attempts have been made to produce structured water through higher than 10 produced via RD plasma. electrochemical cells or filtration media. 0026. In a recent study, fungal activity was altered by 0010 Below are representative patents and published water borne frequency; refer to patent WO2007068831 patent applications relevant to structured water. (A2) 2007 Jun. 21, Luc Montagnier, METHOD FOR US 2014/0302163 A1 Oct. 9, 2014 CHARACTERISING A BIOLOGICALLY ACTIVE BIO 0035 Equipment to generate high ORP water is generally CHEMICAL ELEMENT BY ANALYSING LOW FRE electrolytic and has a high purchase price. Know known units QUENCY ELECTROMAGNETIC SIGNALS Electromag can individually control ORP and pH to get a safe, vicinal netic field frequency memory in water as revealed by grade water pH at the desired high negative ORP. germination responses of fungal spores O. E. Ehinlafaa, G. A. Ibitolab and O. Okunyec a Department of Physics, Uni BRIEF DESCRIPTION OF THE FIGURES versity of Ilorin, Ilorin, Nigeria 0027. It is recognized that providing ionized water orally 0036 FIG. 1 is a flow chart of the process for making the encourages free radical (toxin) removal both extra cellularly present invention.
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  • WO 2014/145352 Al 18 September 2014 (18.09.2014) P O P C T

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    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2014/145352 Al 18 September 2014 (18.09.2014) P O P C T (51) International Patent Classification: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, C02F 3/06 (2006.01) C02F 9/12 (2006.01) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, C02F 9/08 (2006.01) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, (21) International Application Number: MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, PCT/US20 14/030094 OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (22) International Filing Date: SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, 16 March 2014 (16.03.2014) TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (25) Filing Language: English (84) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of regional protection available): ARIPO (BW, GH, (30) Priority Data: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, 61/788,206 15 March 2013 (15.03.2013) US UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (71) Applicant: SUBTECH INDUSTRIES LLC [FJ/US]; PO EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, Box 1226, Stuart, FL 34995 (US).
  • Alphabetical Listing of ATC Drugs & Codes

    Alphabetical Listing of ATC Drugs & Codes

    Alphabetical Listing of ATC drugs & codes. Introduction This file is an alphabetical listing of ATC codes as supplied to us in November 1999. It is supplied free as a service to those who care about good medicine use by mSupply support. To get an overview of the ATC system, use the “ATC categories.pdf” document also alvailable from www.msupply.org.nz Thanks to the WHO collaborating centre for Drug Statistics & Methodology, Norway, for supplying the raw data. I have intentionally supplied these files as PDFs so that they are not quite so easily manipulated and redistributed. I am told there is no copyright on the files, but it still seems polite to ask before using other people’s work, so please contact <[email protected]> for permission before asking us for text files. mSupply support also distributes mSupply software for inventory control, which has an inbuilt system for reporting on medicine usage using the ATC system You can download a full working version from www.msupply.org.nz Craig Drown, mSupply Support <[email protected]> April 2000 A (2-benzhydryloxyethyl)diethyl-methylammonium iodide A03AB16 0.3 g O 2-(4-chlorphenoxy)-ethanol D01AE06 4-dimethylaminophenol V03AB27 Abciximab B01AC13 25 mg P Absorbable gelatin sponge B02BC01 Acadesine C01EB13 Acamprosate V03AA03 2 g O Acarbose A10BF01 0.3 g O Acebutolol C07AB04 0.4 g O,P Acebutolol and thiazides C07BB04 Aceclidine S01EB08 Aceclidine, combinations S01EB58 Aceclofenac M01AB16 0.2 g O Acefylline piperazine R03DA09 Acemetacin M01AB11 Acenocoumarol B01AA07 5 mg O Acepromazine N05AA04