nutrients Article DGLA from the Microalga Lobosphaera Incsa P127 Modulates Inflammatory Response, Inhibits iNOS Expression and Alleviates NO Secretion in RAW264.7 Murine Macrophages Ekaterina Novichkova 1,2, Katya Chumin 3, Noy Eretz-Kdosha 3, Sammy Boussiba 1, Jacob Gopas 4,5 , Guy Cohen 3,6 and Inna Khozin-Goldberg 1,* 1 Microalgal Biotechnology Laboratory, The French Associates Institute for Agriculture and Biotechnology for Drylands, the Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Midreshet Ben-Gurion 8499000, Israel;
[email protected] (E.N.);
[email protected] (S.B.) 2 The Albert Katz International School for Desert Studies, The Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Midreshet Ben-Gurion 8499000, Israel 3 The Skin Research Institute, The Dead-Sea and Arava Science Centre, Masada 86910, Israel;
[email protected] (K.C.);
[email protected] (N.E.-K.);
[email protected] (G.C.) 4 Department of Microbiology and Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 8400501, Israel;
[email protected] 5 Department of Oncology, Soroka University Medical Center, Beer Sheva 8400501, Israel 6 Eilat Campus, Ben-Gurion University of the Negev, Eilat 8855630, Israel * Correspondence:
[email protected]; Tel.: +972-8-656-3478 Received: 26 August 2020; Accepted: 18 September 2020; Published: 22 September 2020 Abstract: Microalgae have been considered as a renewable source of nutritional, cosmetic and pharmaceutical compounds. The ability to produce health-beneficial long-chain polyunsaturated fatty acids (LC-PUFA) is of high interest. LC-PUFA and their metabolic lipid mediators, modulate key inflammatory pathways in numerous models.