( 12 ) United States Patent
US010047166B2 (12 ) United States Patent (10 ) Patent No. : US 10 ,047 , 166 B2 Chen et al . (45 ) Date of Patent: Aug . 14 , 2018 ( 54 ) HUMANIZED ANTI- IGE ANTIBODIES THAT 6 ,037 , 453 A * 3 /2000 Jardieu .. .. CO7K 16 / 4291 530 / 387 . 3 CROSSLINK CD23 ON B LYMPHOCYTES 6 , 066 ,718 A * 5 /2000 Hardman . .. .. C07K 16 /4291 BUT DO NOT SENSITIZE MAST CELLS 435 / 326 6 , 180 ,370 B1 * 1/ 2001 Queen .. .. .. .. .. .. CO7K 16 /00 (71 ) Applicant: Academia Sinica , Taipei ( TW ) 424 / 133 . 1 6 ,685 , 939 B2 * 2 / 2004 Jardieu CO7K 16 / 00 ( 72 ) Inventors : Jiun - Bo Chen , Taipei ( TW ) ; Yu - Yu 424 / 130 . 1 Shiung , Taipei ( TW ) ; Tse - Wen Chang , 6 ,914 , 129 B2 * 7 /2005 Jardieu .. CO7K 16 / 00 Taipei ( TW ) 424 / 133 . 1 7, 022 , 500 B1 * 4 /2006 Queen .. CO7K 16 / 00 ( * ) Notice: Subject to any disclaimer, the term of this 424 / 130 . 1 patent is extended or adjusted under 35 7 ,253 , 263 B1 * 8 / 2007 Hanai . .. CO7K 16 / 18 U . S . C . 154 ( b ) by 0 days . 7 ,531 , 169 B2 * 5 /2009 Singh . .. .. CO7K424 16/ 133 /005 . 1 424 / 130 . 1 ( 21 ) Appl. No .: 15 /318 , 360 8 , 071, 097 B2 * 12 / 2011 Wu .. .. A01K 67 /0278 424 / 133 . 1 ( 22 ) PCT Filed : Jun . 16 , 2015 8 ,080 ,249 B2 * 12 / 2011 Risk .. .. .. .. .. .. CO7K 16 /4291 424 / 133 . 1 9 ,587 , 034 B2 * 3 / 2017 Chang .. .. .. .. CO7K 16 / 4291 (86 ) PCT No. : PCT/ US2015 / 035981 2002/ 0076404 A1 * 6 / 2002 Chang . .. .. .. CO7K 16 / 4291 $ 371 ( c ) ( 1 ) , 424 / 131 . 1 2004/ 0171816 A1 * 9 / 2004 Schenk A61K 47 /646 ( 2 ) Date : Dec .
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