(60) "S"E. E. Primary Examiner Yong
USOO7662824B2 (12) United States Patent (10) Patent No.: US 7,662,824 B2 Leonard et al. (45) Date of Patent: Feb. 16, 2010 (54) ACYLEHYDRAZONES AS KINASE JP 11302173 11, 1999 MODULATORS WO 990 1434 1, 1999 WO 99.15500 4f1999 (75) Inventors: Kristi Leonard, West Chester, PA (US); WO 9951579 10, 1999 Tianbao Lu, Churchville, PA (US); WO 200006566 2, 2000 Robert W. Tuman, Chalfont, PA (US); W 38: 28 Dana L. Johnson, Upper Black Eddy, WO 2OOOO71493 11, 2000 PA (US); Anna C. Maroney, Media, PA WO 2001023386 4/2001 (US); Jan L. Sechler, Doylestown, PA WO 2002OOO661 1, 2002 (US); Richard W. Connors, WO 2002028823 4/2002 Harleysville, PA (US); Richard S. WO 2002040507 5, 2002 Alexander, Newark, DE (US); Maxwell WO 2002O83630 10, 2002 D. Cummings, Wayne, PA (US); Robert WO 2002O85888 10, 2002 A. Galemmo, Paoli, PA (US); Thomas WO 2002O96361 12/2002 P. Markotan, Morgantown, PA (US) WO 2002O96426 12/2002 s s WO 2003O37328 5, 2003 (73) Assignee: Janssen Pharmaceutica NV, Beerse W S.O.R. 3. (BE) WO 2004.0561.78 T 2004 (*) Notice: Subject to any disclaimer, the term of this WO 2005.005378 1, 2005 patent is extended or adjusted under 35 U.S.C. 154(b) by 90 days. OTHER PUBLICATIONS Wikipedia, definition of “Medicine”.* (21) Appl. No.: 11/377,077 STN search result STN-1 1377.077A-clear art. Fahmy etal. Egyptian Journal of Chemistry, (2003), 46(2),313-327.* (22) Filed: Mar 16, 2006 Bieche, et al., Int. J. Cancer 82 (1999), pp. 908-910. O O Camp et al., Cancer 86 (1999), pp.
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