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Medicine@Yale U Medicine@Ya le Advancing Biomedical Science, Education and Health Care Volume 2, Issue 2 March/April 2006 $2 million gift will support training of physician-scientists Of all the professions, learning Training Program () each year, the , known on campus as the dency, a step long medicine requires the greatest time these numbers tell only half the story. ../.. program. since completed by commitment. After four years of These students aim to earn both the “Yale has an outstanding pro- peers in their entering medical school, doctors undertake at .. and .. degrees, embarking gram with a long tradition and a fan- class. “There’s a huge least three years of internship and on a long academic journey that tastic success rate in training success- amount you have to residency before beginning their spe- combines the rigors of medical edu- ful physician-scientists,” Dean and learn with clinical cialty training. At least two additional cation with deep research experience Ensign Professor of Medicine Robert James rotations just for the years are required to become a in the basic biology of human disease. J. Alpern, .., says. “This very gen- Jamieson .., and you can’t surgeon; if the career goal is heart The dedication of these students erous gift will allow us to maintain have a half-baked .. in molecular surgery or neurosurgery, add two has received special recognition from and even improve on the program’s biology and expect to do good re- more years. a donor who wishes to remain anony- excellence.” search,” Program Director James D. But for the one out of stu- mous in the form of a $ million All told, earning the ../.. Jamieson, .., .., says. “There’s dents who enroll at the School of bequest to sustain and expand upon takes about eight years, after which no shortcut.” Medicine in the Medical Scientist Yale’s longstanding commitment to most students begin a medical resi- Gift, page 8 Boehringer and Yale Preserving options, sustaining hope combine strengths in Successful new method new research alliance for freezing human eggs We live in an age of instant elec- is now available at Yale tronic communication, but in some arenas there’s no substitute for face- Thanks to a transatlantic col- to-face human interaction. That’s cer- laboration forged by Pasquale tainly the case in science, say the prin- Patrizio, .., professor of obstet- cipals in a new research alliance rics, gynecology and reproductive between the medical school and sciences and director of the Yale Boehringer Ingelheim Pharmaceuti- Fertility Center (), patients in cals Inc. (), the Ridgefield, the New Haven area, including Pasquale Patrizio Conn.-based division of the global women newly diagnosed with explains oocyte German pharmaceutical firm. cryopreservation cancer who wish to preserve fertil- to a patient at Boehringer Ingelheim, a privately ity during chemotherapy or radia- the Yale Fertility held business, is one of the world’s tion, can now reap the benefits of a Center. top drug companies. ’s portfo- new, uniquely successful form of lio of drugs is weighted toward treat- the egg-freezing technique known fresh eggs has a success rate of eight Emre U. Seli, .., assistant ments for cardiovascular, inflamma- as oocyte cryopreservation (OC). or nine pregnancies per eggs. professor of obstetrics, gynecology tory and autoimmune diseases such Although OC has been Patrizio says that because eggs and reproductive sciences, says that as hypertension, asthma and human attempted in various forms for are not fertilized before freezing, preserving fertility is especially immunodeficiency virus (), so the about years, it has had a disap- the OC technique has particular meaningful for women with cancer. expertise of School of Medicine scien- pointing track record—producing appeal for three groups of patients: “Anyone who has had someone tists in the Section of Immunobiology about two babies for every eggs women diagnosed with cancer at with cancer in their family knows and the Interdepartmental Program frozen—because of damage done to reproductive age, those who oppose that quality of life, the way you in Vascular Biology and Transplanta- eggs by freezing. embryo-freezing on ethical grounds spend your day after the diagnosis, tion would be reason enough for The new method, which and those who wish to postpone is dependent on your hope,” Seli ’s drug discovery team to explore involves bathing eggs in protective childbearing for personal or eco- says. “That this procedure gives you partnerships with Yale. solutions, slow-cooling them with nomic reasons but wish to use a hope is very important.” But Mikael Dolsten, ..,.., liquid nitrogen to minus F and future partner’s sperm. In Decem- The OC modifications were head of worldwide research at Boehr- thawing them according to special ber the School of Medicine’s Insti- devised over the course of two inger Ingelheim’s headquarters in protocols, doubles the success rate tutional Review Board () years at Tecnobios Procreazione, a Ingelheim, Germany, says that the to five or six babies per eggs, an approved the use of the new OC private fertility clinic in Bologna, unusually close scientific cooperation enormous advance over traditional method, and by the end ofFebru- Italy, in response to a Italian afforded by Yale’s proximity to Ridge- OC, says Patrizio. By comparison, ary, women from all three groups law that bans the freezing of field sealed the deal. in vitro fertilization () using had already frozen eggs at the . Fertility, page 7 Alliance, page 6 Non-Profit Org. Inside this issue Medicine@Yale U. S. Postage Lifelines Doctors at an exhibition P.O.Box PAID Mark Saltzman assembles the Museum-based training gives new New Haven, CT New Haven, CT biomedical tool kits of tomorrow, p. 2 meaning to “seeing patients,” p. 6 www.medicineatyale.org Permit No. Small is powerful A very good year The fast-moving world of micrornas, For pharmacology chair, a drug is giants of genetic control, p. 3 approved, a prize awarded, p. 8 New wrinkles for Botox Also Neurologists explore lesser-known Advances, pp. 3, 5; Out & About,p.4; uses of a celebrity drug,p.5 Grants, p. 7; Awards & Honors, p. 8 Want to find out more about medicine at Yale? E-mail us at [email protected] or phone (203) 785-5824. CT scanning expert is new leader of Yale radiologists Following a nationwide search, James A. Brink, .., a Harvard- trained radiologist, has been named chair of the Depart- ment of Diagnostic Radiology at the School of Medicine and chief of diagnos- tic imaging at Yale- New Haven Hospital. James Brink Brink, former vice chair of the department and For Mark Saltzman, the chief of abdominal imaging, came to challenge of biomedical Yale in from the Mallinckrodt engineering is getting Institute at Washington University in “everybody working in sync.” St. Louis. He has served as interim chair since . Brink will lead a department of Mending the human machine more than full-time faculty. The department provides diagnostic graduate days at Iowa State Univer- A fruitful collaboration with Yale’s youngest department imaging services for the Yale Medical sity, where he heard a talk by chemi- Christopher K. Breuer, m.d., assistant Group and Yale-New Haven Hospital, casts a campus-wide net cal engineer Richard C. Seagrave, professor of surgery, is drawing on conducts research in a variety of dis- in search of new therapies ph.d., that was an epiphany.“He both of Saltzman’s areas of exper- ciplines related to clinical radiology gave a stunning lecture, a tour de tise. Since his mit days, Saltzman and imaging science and offers highly With its mirror-like reflection of force, about how the human body is has miniaturized his slow-release rated postgraduate training pro- the grand old houses of Hillhouse just a very complex chemical plant,” polymers into spherical nanoparti- grams. In collaboration with the Avenue and Trumbull Street, the Saltzman recalls. “He explained how cles that can be taken up directly by Department of Biomedical Engineer- sweeping glass façade of the Daniel the tools you have as a chemical cells. By treating tissue scaffolds ing, the radiology faculty also makes L. Malone Engineering Center is one engineer are exactly the right tools with particles that contain mole- important contributions to Yale’s of the most striking sights in New for understanding how this system cules to promote proper cell growth, undergraduate and graduate pro- Haven these days. As the new home works, and designing approaches for Breuer and Saltzman are engineer- grams in imaging science. for Yale’s Depart- helping when the system fails.” ing better, stronger blood vessels Brink is a fellow of the Society ment of Biomedi- Lifelines Saltzman, an Iowa native, soon than has previously been possible. In for Computed Body Tomography and cal Engineering melded his long-standing interest in other projects with medical col- W. Mark Magnetic Resonance and of the (bme), the build- medicine with an affinity for engi- leagues, Saltzman is testing American College of Radiology; he ing’s placement— Saltzman neering that he attributes to the nanoparticles to deliver vaccines for serves on the board of directors of the between the pragmatic outlook of his grandpar- infectious disease, and drugs for Academy of Radiology Research and School of Medicine and Science Hill, ents, all Midwestern farmers. cancer and fertility control. also on the executive council of the a bastion of basic biological research In graduate school at the Mas- Though biomedical researchers American Roentgen Ray Society. A at the northern end of the central sachusetts Institute of Technology at Yale have independently adopted respected educator, Brink has pio- campus—could not be more apt. (mit), Saltzman created drug- engineering approaches for decades, neered technologies for maximizing “Biomedical engineering in the impregnated implants from plastic- the 2003 founding of bme has given resolution in CT scanning while future has to be more intertwined like polymers that slowly and new vigor to interdisciplinary proj- minimizing radiation dosage and risk with basic biological science, steadily release medicines for long ects that team up top-notch biolo- to patients.
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