Table S3: Overview of Cattle Associated Accessory Genes and Core Gene Variants Identified by K-Mer Mapping

Table S3 (Cattle)

Table S3: Overview of cattle associated accessory genes and core gene variants identified by k-mer mapping. Reference Gene Nanea Alias Predicted Function COG Familyb AA # Cattlec # Chickenc # Pigc # Generalistc # Othersc Total Core/Accessoryd plasmid stabilization system NCTC13261_01393 - protein, RelE/ParE family S MKIVPTPKFKNELRHIVNFINLDSSFYAKEFLNDIYSICRNLSFMPYKNRKSLSFDNENIRDLIFKGYIIPYLIDKSKNEIVILGIYKSNLWD55 1 0 59 7 122 Accessory (HicA/HicB) NCTC13261_01392 - hypothetical protein - MNLEFSKETQHFLTNYCKDNNLSEKEVLELALSYLEHKIRIDGYKKDIELYKQGKLKTLDFDETFNDIRKDLE55 2 0 61 7 125 Accessory Enterochelin uptake Cj1355 ceu E P MKKSLVFAFFAFFLSLILTACNSNSNENNASSTTKTNTATVKVLPISMSDEGDSFLVKDSLGENKIPKNPSKVVILDLGILDTFDALKLNDRVAGVPAKNLPKYLQQFKNKPSVGGVQQVDFEAINALKPDLIIISGRQSKFYDKLKEIAPTLFVGLDNANFLSSFENNVLSVAKLYGLEKEALEKISDIKNEIEKAKSIVDEDKKALIILTNSNKISAFGPQSRFGIIHDVLGINAVDENIKVGTHGKSINSEFILEKNPDYIFVIDRNIIVGNKERAQGILDNALVAKTKAAQNKKIIYLDPEYWYLASGNGLESLKTMILEIKNAVK55 90 26 255 64 490 Core periplasmic binding protein putative tRNA (guanine-N(7)-)- Cj1278c trm B J MPNFKSKKIKEINLPYSKDDVEFLWLAKNDNVSLIYTKVQEESFFLQIKKAQNGFVIKGDKHTKPSKIGYLQKALKIFKEGFCEDIINEAFGLKNNALIEKTPFIVDNFDELLSKLQGKIYIEIGFGSGRHLLYQAKENPNVLILGVEIYNPALTQVAKLAKVQNVNNILLIQSDARLLLSVLKSKSVEKIFLHFPVPWDKKPHRRVIGKDFCKECARVLTQNGRFELRTDSFEYFNFTLEQFLTFPAPKFSLRKNENLEISSKYEDRWKKQEKNIYDLWVWNFNQECKNYELNEFNLSSVEFSKEDLKKIEQNFKNITIKKDDFFLHFESIYKQDENLLLKVAFGAFNKPEHCYLHLDKTIDFVFKEPFKIQENIKAINELKEILKVQFKI55 90 26 255 64 490 Core methyltransferase phosphoribosylamine--glycine Cj1250 pur D F MKIMILGSGAREYSIALALRRVDKNLEFYFAPGNGATESLGTNLNLKDPVVLATYAKEKGFDLCIVGSESFLAEGVVDIFKQQGLAIFGPSKAAAMLETSKSFMKSFLKKYRIKTAKFLNTNDIEKAKNFIYSLTPPIVVKADGLCAGKGVIIAKTHEEAIKETAKMLSGESFGDAGKLVVIEEFLDGYELSIFAVCDGNDFVLLPAAQDHKKLLDNDQGPNTGGMGAYAPSSLANESLLRKVQKDIILPTLAGMKKEGAEFCGVLFIGAMIVGNKPYVLEFNVRFGDPECEVLMPLIEDPLELILAATQRRLRHAKIKIKKEFAVGVVCASENYPYKSSPKSEITVNNIPENSHISYAGVSLEDGKLMADGGRVLVCVGTGKSIEEAQKNAYKLCDNVNFKGKQYRKDIAHQVLK55 90 26 255 64 490 Core ligase GMP synthase (glutamine- Cj1248 gua A F MKKADILVLDFGSQYTQLIARRLREQGVYAEILPFNVSLADIKAKEPKGIILSGGPASVYATDAYFCDKGIFDLGLPVLGICYGMQLMAHHYKATVAPAGHKEYGKANIEIKKDSALFKNLPKKQTVWMSHSDKVENLPDGFEVLATSENSPFCVFGNEDKKFFALQFHPEVQHSEFGKNILKNFAKYACNCESVWNMGSFAKTQAEKIREEVGNDKVLCAVSGGVDSSVVAALLASAIKEQVIVVFVDNGLLRSGEKEQVEFMFKNTLGIDLISIDASEIFLSRLANVRDPEQKRKIIGNTFIEVFEEEAKKHKDVKYLAQGTLYTDIIESSVVGASKTIKSHHNVGGLPEKMNLKLIEPLKEIFKDEVRALGLELGLSKEVVYRHPFPGPGLAIRIMGEVNRPSLELLRKVDVILLEELKSTGWYDKTWQAFCVLLNVKSVGVMGDNRTYDNAVCIRVVDASDGMTATFSHLPYEVLENISRRIINEVEGINRVVYDISSKPPATIEWE55 90 26 255 64 490 Core hydrolyzing) Cj1246c uvr C excinuclease ABC subunit C L MTKENLENELKTLPNSAGVYQYFNQEGKLLYVGKAKNLKNRVKSYFAFTPNLHANPRNSLRIQKMIEETVHLEFITTNSEADALILENSFIKQLHPKYNILLRDDKTYPYIYVNFEEEFPRFEITRKLVKKSKIKYFGPFFKGARELLDALYLYYPLKQKASCKSPCIFYQISRCLAPCDKRISKEKYLEILDEAMHALLNPSILIKNLEKQMLVLAQNENYEEAAKVRDQIVTIKDLEVKVEMDVAKLEDFEVFALAFEDSMLSTLRFVVQNGKIISANSKITPIKNDIQWDQNEIYKQLILENFSMDIPLLANVIYVYEEFEDRVLLEEILSQRFDKKISIKIPKIGEKRRICDLAFQNALLNIEKEQKNHDFTIQKELKFYFELENLPNDIEIFDNSHLQGVANVGAMVTYRINSWDKSKYRKFHLKHKNDYDQMREVLTRRALDFDKIPPPDLWLIDGGKALLDLAKKIIVSSGANVDILAISKEKIDAKAHRAKGGAKDKIHSLKGEFSLSINDKKLQFLQKLRDEAHRFAISFHQNTKKKQDLKSSKLANLGLSSGVIQKLLAYYGNFESIYKADFKDLTMLVGRKAAQKIKEN53 84 26 247 63 473 Accessory Cj1240c - Hypothetical protein - MKKIILLLGLSLVSLGALSFDELIYKDEVKPSFDCSKVKDDGKSDDELMICNEIGVRNEFENKKLALVDNIYSSLYQNISKKADKKTKKDFKAISKKMIKERKICIKNMQNTKAGENPILPLLNASDCMQEAYAKALLELTQRAKKDIKTKEVLEQIFKNKVDKYENLLTQSLNTNKDLQDFIDSLAKEDLIDSRAKFKLWNLN55 86 21 249 64 475 Accessory glycyl-tRNA synthetase beta Cj1234 gly S J MSELLIEIGTEELPAIPLLKELANIEKKWKNVLEEYCLVSDFKFYYTPRRLVFFHENFADKQEDSFAEFIGAPKNVAYKDGVLTPAGQSFLQKAGISENELAFKEIKGKEVLYHQKAIKGLQSQEILGEMVEKFLKSLSFGKSMRWGANSFEFIRAIRSIACILNDELVNFQSYGVKSAKKTFIHRSVSYDLQDFNNAKEYFELLEKNYIILDPIKRKEKILEQFKLIESQKNIQIGEDEELLAEVVAITEYPNALLGSFEEEFLEIPSEVIITSMRENQRYFAVFNDKGLSNHFIVVSNAVCKDYSKITHGNERVLRARLSDAMFFYQNDLQSGLKPEKLAKMTYLEGLGTMQDKSLREIKIAEILCQMLHNDKIENISTALKYAKADLATQMVYEFTDLQGIMGSYYAQKMGLDYEICLAIKEQYLPNSEQAPLPSTEFSSIVALANKLDTLIGLFSIGKIPSGTKDPYALRRAANGIIKIALNLNKEFDIQILLEKLSSHYKSFDMQILKDFIFERLYTFYTVNASFVKAVLSSQNTDLIHINQSVNALIKLSKKDNFNENFATFKRLANIATKNPHKVDESLFVQEAESKLYKAFQEKTKANSLQEKLENLFALKPFIDEFFNQVMINAEDEKLKNNRQALVYEIYAEFLKIADLKELSL55 90 26 255 64 490 Core chain putative HAD-superfamily Cj1233 ppa X S MINVFFDMDGTLIDSANAISCAVNEIRQDLNLAPLSREIIMQTINTPNIDWAKELYNIENFHHSSFKEGYEKYFVKHYEQSVVLFEGVKELLEFLKNKNCFLAIATNAPQSSLSSILKKHQIIPYFDKILGVSLGIEPKPHPMMLELLKSEAPYKTSVFIGDSQKDKECAKNANLPYFHAKWYQKDLKENEFSNASELKGFLQKYL55 87 25 255 63 485 Accessory hydrolase Cj1228c htr A serine protease (protease DO) M MKKIFLSLSLASALFAASINFNESTATANRVNPAAGNAVLSYHDSIKDAKKSVVNISTSKTITRANRPSPLDDFFNDPYFKQFFDFDFPQRKGKNDKEVVSSLGSGVIISKDGYIVTNNHVVDDADTITVNLPGSDIEYKAKLIGKDPKTDLAVIKIEANNLSAITFTNSDDLMEGDVVFALGNPFGVGFSVTSGIISALNKDNIGLNQYENFIQTDASINPGNSGGALVDSRGYLVGINSAILSRGGGNNGIGFAIPSNMVKDIAKKLIEKGKIDRGFLGVTILALQGDTKKAYKNQEGALITDVQKGSSADEAGLKRGDLVTKVNNKVIKSPIDLKNYIGTLEIGQKISLSYERDGENKQASFILKGEKENPKGVQSDLIDGLSLRNLDPRLKDRLQIPKDVNGVLVDSVKEKSKGKNSGFQEGDIIIGVGQSEIKNLKDLEQALKQVNKKEFTKVWVYRNGFATLLVLK55 90 26 255 64 490 Core putative cation transport protein / putative heavy- Cj1163c czc D P MYKFLSHEPLANKSCHHNHEEHSHEHHHSHADARSMDKKILKISLLMTFSMMLVQFIYSILSNSLALLSDTLHMFSDVFALALSFLAIIAVEKWQDHQKTFGYFRLEVLVAFINALTIVLSALFIIYEAIEKFINPKEIDAKTMIIVAILGFLVNGINALMMFKGANLENVNMKSAFLHMMSDLLGSLAVIIGGIVVYFSGIVYIDTILAIVLSILLLRWAIILLKQSANVLLESSPVDIEKVRQVLLLNPSVDEVVDLHITQITNKMLVASMHLKVKVYDLKEFEKLSQDLSHKLLYEFEIGHITIQPIRSENEI55 90 26 255 64 490 Core /MKFKVKNVNCMNCVNLIKNSLEDEFGNIEVDLDQKILSLNLEENQVSNFTKEFQDLGFEIVERL metal-associated domain protein putative cation transport protein / putative heavy- Cj1162c cop Z P MYKFLSHEPLANKSCHHNHEEHSHEHHHSHADARSMDKKILKISLLMTFSMMLVQFIYSILSNSLALLSDTLHMFSDVFALALSFLAIIAVEKWQDHQKTFGYFRLEVLVAFINALTIVLSALFIIYEAIEKFINPKEIDAKTMIIVAILGFLVNGINALMMFKGANLENVNMKSAFLHMMSDLLGSLAVIIGGIVVYFSGIVYIDTILAIVLSILLLRWAIILLKQSANVLLESSPVDIEKVRQVLLLNPSVDEVVDLHITQITNKMLVASMHLKVKVYDLKEFEKLSQDLSHKLLYEFEIGHITIQPIRSENEI55 90 26 255 64 490 Core /MKFKVKNVNCMNCVNLIKNSLEDEFGNIEVDLDQKILSLNLEENQVSNFTKEFQDLGFEIVERL metal-associated domain protein succinyl-diaminopimelate Cj1048c dap E E MNAKEFLIELLKFKSVTPNDDGALNFIAMELSDFEAFFIEKEGVKNLLLTKKFKDEGEHLAFGGHVDVVPAGEGWSSDAFVPMEKEGFIYARGAQDMKSGVAAFVDAVKNADFKGARLSLILTSDEEGEAIYGTKAVLEWMQERDMLPDYAVVAEPTCVKKIGDSIKIGRRGSINGKLLIRGKQGHVAYPEKCINPVHDFAPVLKLLAGFDLDPGSAEFSPSKIVITDIRGGMGVCNVTPNDLKLMFNVRNSPDTSLEDVKSYVEKICHGLNYELELKQSSEAFLTNIDNKIVQKMNESVQKITHEVPELNTKGGTSDARYFAKYGVKVVEFGVCNDRIHAIDERVSIEEFEKLCLVFKDLIENF55 90 26 255 64 490 Core desuccinylase dna methylase-type I NCTC13261_01099 - restriction-modification V MIEEILKDSDYKLDLFSKKAIAELETKIIAKTNKNNQIIYYTNCLIRDKEIKLTPEEIVRQLYIDKLLNEYNYPKDMIKIEFGVHFGREVKRADIVIMDKIQITVPYIIIEVKKPKLKDGKEQLKSYCNATGATMAVWCNGKEISYYHRKDPNYFESIPNIPASNQTLPDLLKVKFTFDNLIKEDILKSQKRSLKNLVTEMEDEVLANAGVDVFEECFKLIFIKLFDELEGARDRTKSLEFRNYGESDSELKQKIEKLFDKAKKKWEDVFNNDEKIKLSPSHLSVCVSSLQNVKLFNSNLEVIDDAFEYLVNKSSKGEKGQYFTPRYVIDMCVKMLNPKKDESMIDTASGSCGFPIHTCFYVWRSIYKERGIEASHLFTAQEKISECQDYVKEKVFGIDFDEKSVRVSKMLNLIAGDGHTNVLYLNSIDFDRWDEWVKDDEDWQDVYFEGFKRLKNLRVTKNQNRDFKFDVLMANPPFAGDIKESRILARYELGKKENGKPQSKVGRDILFIERNLDMLKPGGRMAIVLPQERFNNSSDKYIREFIAQKARILAVVGLHGNVFKPHTGTKTSVLFLQKWDDKLCPKCEDYNIFFATMNEPSKDNSGEKIYYPLLDSHDHLVVKHDLFHPHLEGDEPIKQKDESQEEFDKRIQEYRLNVEKYKDLQKDGIAEAFIEFAKAENLSFWKE30 34 0 46 27 137 Accessory system NCTC13261_01098 rlf A RlfA S MDNMKEFKIFCDESNHLFYKDNPTLCSRVMVLGALKVPSSEIIKINKTIKYLKHKYKYNKEIKWTKLNLSQKGFYDELLEFFFSSVYMWFKAVLIPNKTILQHDIYNQGDHDLFYYKMYYQALHNLIDIDTKIKIYLDYKDTKSGDKIKGLEKVLFNKFKQSVNIKIFTIQSHESNIVQLVDLLIGAISYKARNDIEHVSEIKNYIINKIETLANIELDAGTPPWENKFNIFRIQLSKGEQ29 8 13 2 15 67 Accessory NCTC13261_01097 - hypothetical protein - MYYLLDFSTCKCENEKFDLAYKIFKQDFIEVPLYLAGCIYIDPQSHKKHKGKEKIFWHITTRENKQNKTREFDSQRACRINWIKQIIINHTHPEIKAFYYKEKRAIRFYLWLHNHNFIVILQKLGRSSSFLVTSFYIDKGYNKNIYEKRYRNYINGNDIELKNCEWF36 35 14 50 34 169 Accessory Putative uncharacterized NCTC13261_01096 - V MNLNQTLQEKYPHLEVSVLKLSEVKKNIDFRIDDSFWTMKLIYNNKLNYKKIGECLLKSQYGISINMNEGGDGIPIYRMNDIDNMLCNFEVKKYALIDKNELQTFRLNYGDVLFNRTNSYEFVGRTGIFYNNRENFVFASYLVRLVCNKEILLPEYLTVFLNTHIGKKEIRRRARPSINQTNVNPEELKEIKIPIFPMEFQLEIQNLVKDSHKALEESKELYKKAEETLYLELGLDPKNPLQSLLDSKTNNPTNSPNISIHTLKESFLKTGRLDSEYYQSKYEDIEKMIRSYKDGFCNLKDLVNDISSGFAFSSDDYQDVGELVLIRINNIKNATLDLSNVIYLKNEAYNLSPKDKIKKGDILISMSGSIGLSCVVRDDISAMVNQRILKISIKNFNSDVLVLLLNSFICKMQFERIGTGGVQTNLSSIDMQNILIPKIDSTTQEKIAKYIQENFNLRKKSKQLLDNAKIKVEEQIQGKV36 30 0 47 21 134 Accessory protein Cj1047c thi S thiamine biosynthesis protein H MIINGEKFEFKELRFMDFIKEKGLKIELIALELNGEIIPKSEFENLILKENDKAEIVSFVGGG55 90 14 254 51 464 Accessory Cj1008c aro B 3-dehydroquinate synthase E MQVEVKLKENAYKVYIDELEELEFDSKVFILSNPKISGLHLKTLLSKIKAKEIFIATVKDGEEYKNLSTMEEILNQMFNSKLDRKSVLISFGGGVISDMGGFAASIYQRGIDFINIPTTLLACVDAAVGGKTGVNNNFGKNLIGTFYQPKAVYCESFFLKTLSSRELAAGMAEFIKMAAMFDDSILDFIEKIDEKSFLNATCENEIFTQIIARSIELKSRVVEQDEKESGLRMLLNYGHTFAHVIENFTDYKLYLHGEAVAIGMVMANQLALNLGLLDKMQSQKIKDILLKFGLPISYKINNVDEFYEAFFMDKKSSNKKINFVLASPLGKGLIKGDISKEDIIATLREFQ55 90 26 255 63 489 Core putative Cj1002c six A phosphoglycerate/bisphospho T MKKIYIIRHAKASKSEDIDDFERKLTKSGKEDLKKLFKNLASHEIHPDLVLSSPAVRTAKTAKKIAKFYNFDKNRICFDERLYLCNVENLLKILQDIDDEFNEVFLVGHNPSLMELGELLSSLCLASFPTSSILCLEFDIKEFKNLKKHSGKLVFFEHVRKLKEEKDLGF42 88 23 216 32 401 Accessory glycerate mutase RNA polymerase sigma factor Cj1001 rpo D K MNAKTQEAELEELFQENAKDYITYEKLVKYLTKQPSASTAKKVQALMKKHKVQLFSAAEIAQMKNIEDAKRLQEEKQKLQDTSLENEFDLANENDLLEWSRSDSPVRMYLREMGQIALLNKDEEIEISKKIELGEDIIIDAFCSVPYLIDFILDYKEPLINRERRVKELFKSFDDEEKSDDKLDELDIDEDEENETELESDEENTKKNSKKEDERTLKVIEKFKALEKAKKDWLKTSKDKESGDELLDKLSIAFKKNILKEKLMDLGPTSKLISEIVKSMETALKSDEEFDKELKRLEYRLPMFSDELKKRHADILKDITKLSKEEITERALETTMVSTYMEIKKLFQTKEASEKSFDLEKSRLKEILEQIKRGKKISDEAKGRMAKSNLRLVVSIAKRYTNRGLPFLDLIQEGNIGLMKAVDKFEYKRGYKFSTYATWWIRQAISRAIADQARTIRIPIHMIETINQINKIIREHLQKDGKEPDVSVIAKEVGLSVDKVKQVIKITKEPISLEAPIGNEDDGKFGDFVEDRNSLSPMDHILKDDLKEQIDEVLDQLNDREKAVIRMRFGLMDDESDRTLEEIGKELNVTRERVRQIESSAIKKLKHPKVGRKLKNYIEGWK55 90 26 255 64 490 Core (sigma-70) putative integral membrane Cj0999c yei H S MKTSFLAHSVAIVRSNFKGLLFTACIVIFAMYLSSVQSIKDTTHLAATAFAIIIGVLLSPWFFKYQHHFQAGVHFSAKKLLRLGIVLYGFNITLTELLSVGLKGFLLSAIVIFFVFIIALFVGMKIFKLDKETSMLVGAGSAICGAAAVLALESSLKSDPFKGILAVGTVVIFGLVFMFLYPIAFSLNLFPFFDQNAMGVFMGATLHEVANVAGAAEMAKDMAGFEQGASNVAVIIKMMRVILLVPFLLIVTYFFAKNQHSSSGKTAKSITIPYFAFAFLGMIVLNTYLASKESILGIATSDIISLGKTLCTLCIVFAMAALGLQIDFKKFLKSGSRVFGLAFVLGLVLIFGGYFLTLAFKGILW55 90 26 255 64 490 Core protein

Seite 1 Table S3 (Cattle)

delta-aminolevulinic acid Cj0995c hem B H MFKRFRRLRLNENLRSMVRENSLSVNELIYPLFVVNGTGIKKEISSMPDVFQMSLDEILKECQNVVNLGIKAIILFGVLENEKKDSCGSDALDDEGLVARSIREIKKNFPDLFIISDLCFCEYTDHGHCGIIDPKTKSVDNDVTLEISAKQALVHARAGVDMIAPSGMMDGVITTLRKALDKEGFENLPIMAYSTKFASSYYGPFRDVAESAPSYGDRKSYQMDFANGKEALEESLEDEVQGADILMVKPALAYLDVVKEISLHSNLPLCVYNVSGEYAMLKAAKNAGVIDYEKVLYETMIAFKRAGAKLIITYHAKELAKMLKGEK55 90 26 255 64 490 Core dehydratase ornithine Cj0994c arg F E MKHFLTLRDFSKEEILSLVNHASELKKEPKKLLQDKTLAMIFEKNSTRTRMAFELAITELGGKALFLSSNDLQLSRGEPVKDTARVIGAMVDFVMMRVNKHETLLEFARYSKAPVINALSELYHPTQVLGDLLTIKEWNKMQNGIAKVAFIGDSNNMCNSWLIAAAILGFEFSIAIPKNYKISPEIWEFAMKQALISGAKIFLSHDKFEALKDKDVVITDTWVSMGEENEKERKIKEFEGFMIDEKAMSVANKDAILLHCLPAYRGYEVSEEIFEKHADVIFEEARNRLYVVKALLCFLDNQRGRE55 90 26 255 64 490 Core carbamoyltransferase putative oxidoreductase Cj0991c glp C ferredoxin-type electron C MKFSQISDACVKCGKCIPVCTIHEENRDEITSPRGFLDLLAAYKEGSLELDKEAKKVFESCFLCTNCVEVCPSKLRVDNAIEEVRYDIAKKFGIAWYKKLIFFFLRRRKILDLVAKLGYVFQSCAFKIQNENENTGMKARFSMPFVKKGRLLTSFNKKSFLNSNPKFINNDGEKTIGFFVGCLANYFYIDTANAVLKIAKELKINVDLMKEQVCCGAPQFFTGDFKSVEVLAKKNIEYFEKKLEKLDAIIVPEATCSAMLKIDYEHFFIMQNDLDWAKRAKCVSSKIYMASEYFYKFTSLEEILKTKNKFNYSITYHDPCHARKMQGVFKEPRELLKTNYHFVEMSNSNTCCGFGGVSMQTDYYDRALSVGLKKAQMIDESKASVVSAECSACRMQISNVLEQNSSKVVFASPLELIAKAL55 90 26 255 64 490 Core transport protein Cj0967 - putative periplasmic protein - MIIHGPSKAYASLAAAHISAGYIDSGTDKNFQASKNLLDIDGFNLDMYMNHDKQPLAYNSVLFADFWGGKTEQGQALDNTINLRDIKNLKKDKNNENIFAQALFNFYAGASNNGEANYNTLNIELKHPLEIANNFLGYNQHSFYGGFATKGANHNTINIKNDLTTTDLSQSYKDALNIVAARTLEGNADYNKVYINNSMSTLPVYIYTAKKNILNNQDFYPSSANNNEVVIKDFASFRNLTVLTEAKEASYNTINYNNVQSITDASNIDKGSKIIIRALDKANHNTIDIKNYSSNAADNAYLIMAYNEAAYNKIIINDTLFGVASDKREGILSIIAGLSNNGHDNTLIINNLNLDEYKNNNSVFIAPSAITGLSEAKSYNNTLYRREFKYI37 79 26 192 45 379 Accessory Cj0967 - periplasmic protein - MREDEVLSFKARHGVNTAGHSIKTVRVLPFLITAKTDHADASYNKLILEQGELSSVFYLKPKDTHIKNPSNSKSNQRMNFLMSSTFTHYSNASYNQTILQKDAHISMGVENTYDLALNGAPYLIGAIATYGDSTNNSLNIEAGSSVEFFTSLPKKDKNGNNTFDERITHLVGGLAYQGNVKNNKIFSKMLI37 54 26 60 34 211 Accessory Cj0964 - putative periplasmic protein E MKKIFLIFFLSCFLLNAKEQKLVDVKPVENFYPKLSVQECNTNCLFDLLESRLYLSFLSEFADQNDQFLSNVYAKLLNSITDFEKNVQKITSVKLAIIIPEKTIKSYSNTIINSSIAYLLRQRAEIKVKVFLTGTEDSDKIRAALDAAQAQGYQYAIAGFTLKGANELKNYSGNMKIFIPTIHKNNIQISNQNIIFGSIDYDAQIATLLSKSNTNIAIFSDGSALSSNLNSRILAQNNNARIYTIEGEKLDFSRLLRSQGGVNNASIFFNTPLIKTALASSQLRIYNIHPYVLLSTQINYNPTFLSLTQQGDRENFIIANSINNHDDNLVYLNEIFNQSIDYNWIAYATSIGVDYFYTEFLNKKSESLFDEKIKNSQVDYKVRLMQGKQASFEELK55 90 26 255 64 490 Core Cj0959c yid D hypothetical protein S MGIEKTRMFQMICLKILRFYQKFLSPLKPAACRYYPSCSEYALWQFQKKNFFLAFFSTFFRVLRCNPFFKGGFDYPRVSKNFYPINLCFKPIFLAKKQLCFLYIPYKNKSFYLIKIIFKRTNQ55 90 26 255 63 489 Core Cj0946 spr 7 putative lipoprotein M MKSCLYFTFIVLFLTACSTKNLTSLHHENLEQKNENQHYAKLEYEQNVSILPQFTYDINFDAKRYKKYFFNPWHDSFKNYKGQNIFWSFPLYLNSKNTYYFFNKQIIPLSWFKNAINNANIQEFGKLNQKALIIQNTIIKNLPTQRAILKNPFFENEGIPFDYASDGILNTGSPVLISHFSKDKRYAFVLGEAGFGFVESKNLEFFSNNRAKIYENLNFITPLKEKFAIYSEDGKFFFESRIGAIYPYYKEDKNYFYGKIGSKKYKISKKDVSKFPLQFNDKNLKNQLSQVLNLPYGWGGYNFERDCSLLTRDIFSAFGLYLPRNSAAQKNSFNHFDISTLSNSQKKDFLNRFGKAYLSLLYLPGHIMLYAGQITDNNIAIHNIWGLRKDTTQRLLISSSVITSLEIGKNEILEDNLLLSRLKEISFINLNEQEKEQIKSYLENIQNK55 90 26 255 64 490 Core Cj0944c - putative periplasmic protein - MKKIFLSVFLVLSLNAQNLEIDKIRTDLYSKSGTNVLKKVEISLEFDGNNLKENENKLIDAVNTVISGFFYEDIFTEIGKNNFKKTLEKFLDKKYKIELNDIYIISLSGVEKFDLEEFKRFLESTEAKEKGMGSEVKKALENLEVPKTQVPSVEKIPTPSVPNLEVKQVEQLFKDPDEENKNDNGEINIDNLNTPKMTPDIEEKIKRDLIANPPQIFKENNASKPYHLPQTGYDIKLDENSTQN55 90 25 255 62 487 Core putative glutamine transport Cj0940c gln M P MSLFTQKNKNFKPLKPLSKSKIITNLILLILFLILFCYCSFSISAYHFDFSAIATYKEKFLQGFLNTLIISFFSLLLSIILGGVFCAFSLSSIVFLRFLSTFYIELVRGTPLLVQVLLIYYIIANNLGLDNRYVAGVIILSCFSAAYLAEIFRAGILSISISQLESARALGLKEMQVFAYVIFPQALKNILAPLSGQFANLIKDSSLLSVIAVNELTQSAQEINSYTFATLEAYVILAITYLVLTLPISIFSRYLERKCQK55 90 26 255 64 490 Core system permease Cj0939c - hypothetical protein - MLIIGHELLKNLDFSFIESVEEVKDNKVYCIVYDEKLISYLSQNDFEFAILVQNKDEIFLANALGAKFLLCNDKKLAKFASKVAEFYVFDSRVLMIVDKLENFKKFYKLKIDGIILKDNIDNFPKN53 90 26 255 63 487 Core

putative 2- acylglycerophosphoethanolam Cj0938c aas EGP MQKKSFLKIYGLIPFLLIAFINAFVDLGHKIIIQNTIYKTYEGSEQLFLNVIVNALILLPFILMLSPSGFLADKYPKNIIMKISTIFNVILTSIICICYYSGAFWMAFIFTFIMGAQAAIYSPSKYGFIKELVGKDFLAMGNGVINAVSIVAILAGMAFFSLSFESLYSSTYNQTDEILKEVAPLGIVLILFSCIEVFFAWRLPKLKQTNKDLVFNKKDYIRGKLLINNLKLVFKNKTIWFCIIGISFFWAISQLYLVSFPVFAKNELFIENTFYVQISLAFSGIGVILGSLVAGKFSKNYIELGLIPLGVLGMFLMAFLMPYFVSLLSYSFLFFFFGFCGALFIIPLNTLIQFHAKENELGQILAGNNFFQNIAMLGFLLLATLFAKFEINVVYLFYFITLVTFIGSFYILLKLPFSLVRILLSIAFLQRYRLLVEGFENIPEKGGALLLGNHISFIDWAVVQMAIPRKIYFVMERSIYSKWYIKIFLDKFGIIPVSSTGSKTSLELIAKHIKEGNLVCLFPEGTLSRHGQLNEFKAGFELACEYLSEDDGKIIPFYIRGLWGSAFSRSDEEFSARNRTLNKRKIAIAFGKAMPLHSKKDEVKAKVFELSFMAWKSQCEAMHTIARAWIDTAKKNLNQIAIIDTLAGDISYRKMLSLSLILNFFIKRKSKELNINPQRGSYAPKEEAIGILLPASFASSLTNLSVLIAEKIAVNLNFTAGEKALKAAIKNAQISQIYTSKTFLEKLANKGINLNFDTNIHLIYFEDIVEDFKMQKTKIFSMMLAVSIIPSFILKTIFTPSKNNLAIAAILFSSGSEGSPKGVMLNNRNILSNIAQISDVLCTRNNDVILSSLPPFHAFGLTVTTFLPLLEGIKSITFADPTDALGIAKAVAKNNVTIMCGTSTFLGIYARNKKLDALMFESLRIVVSGAEKLKNEVRTAFEMKFKKSIFEGYGATETTPVASVNLPNRFDADYWLIHRANKEGSVGMPLPGTAVRIVDPNNYENLKTNEDGLILIGGHQVMVG45 82 25 215 34 401 Accessory ine acyltransferase / acyl-acyl carrier protein synthetase putative sodium:amino-acid Cj0934c IV02_29000 P MRTYFSKIGFVLAVAGGAVGLGNAWKFPTLSAENGGFVFVLLYLFFTLTIGFSIFLAEVAMGRLSKSDLANAYSNLAIKYGNRWRYGGVFMLGGIFVLSFYLVIMGWVLKYTVVSLYYLPKTLDEAASNFQNLITTNLTSSVFFFTLSFFLTLLIVSKGLIKGIEKLNVVIMPSLFLMLVFMLFYCMGFKQGFANAFSYLFYPDFSHFKFSSIAEALGLAFFTLCLGIGCIVTYSSALDKKTNFIKSSVYIVLINLLISFIMGLIVFTFIFEFGADPHTQGAGIVFVSLMSLFNQLGALGYIFAFCFFLALFFAGITSAVSMIEPLTFYMINNYQISRVKALFLIGLFVFVFGICCILSLNLNFFSMFSFFGKDFFTLLDKLTSNFLLPLGAIVCSIFVGFFMNKKQIYKIFSKFISRKIFLIWLFFIRFISPIAIILVMCYQIFV32 81 0 175 15 303 Accessory symporter family protein putative pyruvate carboxylase Cj0933c pyc B C MAKKFIDVMDTSFRDGFQSVYGARVLMDDFFSAVEAAKEAGITHFEFGGGARFQSLYFYLNEDAFTMMDRFRAIVGKDANLQTLARGVNTVTLDTGNSELIDLHAKLFAKHGTTTIRNFDALNDVNNLKFSGECIVKHGLKHEITITLMDLPSNCKGAHDVPFYEKILKEILTAEIPFHSICFKDASGTSNPNKIYKTIKMARKILPQDTHIRLHTHETAGVSIACYLAALEAGVDGIDLAAAPVSGGTSQPDILTMMHALKGKDYDLGGLEEEKILRYEEVLKDCLKEYFLPPEATMVNPLIPFSPMPGGALTANTQMMRDNNILDKFPQVIHAMREVVEKGGFGTSVTPVSQFYFQQAFNNVMFGPWKKIAEGYGKMVLGYFGKTPVTPDANIVELASKQLNLEPTTELAINIADKDESKSIAYTKTLLEKEGIETSEENIFIAAACKEKGIAFLKGEAKVNIRKLASMPKPMSVDENKFTVAVNGNKYHVEVSYGFDKDVNVKSVKKVEENKNIISSNSTSSVDAENEVLAGISGNVFKIYVNEGEEVKSGQAIMVLEAMKMEIEVNAPKDGIISELCIKIGDTVNEGEVLAIYKN55 90 26 255 64 490 Core B subunit phosphoenolpyruvate Cj0932c pck A H MKKFDNLGLDNIKEIFHNLSYDELNAHEKANNEGLSTDNDTFCVDTGIFTGRSPKDKYFVKQDPSSKYIAWGKINQPITKELFDKLLAKAKQELSGKKIYVQDAFCGASLQSRKAVRFVTEIAWQAHFVKNMFIRPSQEELENFKADFIVYNACKCINEDYKQDGLNSEVFVIFNVEENIAVIGGTWYGGEMKKGIFSMMNYWLPLENKLSMHCSANVGEKDDVALFFGLSGTGKTTLSTDPKRRLIGDDEHGWDDEGVFNFEGGCYAKTINLDPEHEPEIYGAIKRNALLENVVLRADKSVDYADASKTENTRVSYPIEHIENHEPSLKAGHPKNIIFLSADAFGILPPVSKLSKEQAMYYFLSGYTAKVAGTERGITEPQATFSACFGEPFMPLHPTVYARLLGEKIEKHEVNVYLVNTGWSGGSYGVGKRMSIKATRACINAILDGSITKCEFENFEVFDLAIPKALEGVESMLLNPINTWSDKNDYIATRDKLAHMFIQNFKRYEDVKEGIEFSKFGPKI55 90 26 255 64 490 Core carboxykinase (ATP) putative ABC-type amino-acid Cj0920c glt J P MNESVGFVEHLRQILTSWGLYDENSISPFAVWKFLDALDNKDAFINGFIYTLEVSILALLIATIFGTIGGVMATSRFKIIRAYTRIYVELFQNVPLVIQIFFLFYALPVLGIRLDIFTIGVLGVGAYHGAYVSEVVRSGILAVPRGQFEASASQGFTYIQQMRYIIVPQTIRIILPPMTNQMVNLIKNTSVLLIVGGAELMHSADSYAADYGNYAPAYIFAAVLYFIICYPLAYFAKAYENKLKKAHLTR55 90 26 255 64 490 Core transporter permease protein Amino acid ABC transporter, Cj0919c tcy B_2 P MENVFNAQNIEFLMQGLFLTLKIALATCIISIVFGTFLAITKNYGDRLSKFLAACYIDIFRNTPLLLWMLAACFVLPVFFGQFPQAFWGTIGFSLYTSSVMAEIIRGGLNSIPKGQFEAAYSQGFGKFFTLFYIILPQTFRKIIPALLSQIVTTVKDTAYLAGLGIAELTYNSKTILAKLTSFEEILAMIGVVAGIYFIICFSLSMLVRYYAKKTAYIS55 90 26 255 64 490 Core permease protein PEB1 putative integral membrane Cj0917c cst A T MTQLSTKILWLFVATLGAICFGYLALQNGESVSAIYLVVAAVCIYMIGYRFYGRFVAYKVLELDKNRATPALVENDGRDFVPTNKAVLFGHHFAAIAGAGPLVGPILAAQMGYLPSMLWILVGGVLAGAVHDFVVLFISTRRKGRSLGEMIKDEMGKFTGGVAMVAIFGIMLIIIAILAMVVVKALAESPWGLFTIAMTIPIAIFMGIYMRFIRPGRVGEASIIGFVLLILAIHYGSVIAADPYWAKIFTLEAPTLAIVMMAYGFIASVLPVWFLLAPRDYLSTFLKIGVIVVMAVAIVLVAPDLQMPKANTQYFDGTGPVFAGGVFPFLFITIACGAISGFHALISSGTTPKMLENETHALAVGYGSMLAESAVAIMALICACILHPGLYFAINSSSALIGTDVVNVAQTISSWGFSITPEEITTLTANIGEHTILSRTGGAPTFAIGVALILHELFGGVDLMAFWYHFAILFEALFILTAVDAGTRACRFMVQDILGNVYKPLGDIHNYPAGLLATALSVAGWGYFLYQGAIDPKGGIYTLWPLFGVSNQMLAGMALLLATTILVKMGKARYTWVTLVPAVFVLVATLYGGIQKIMPYEEGNKVANAVSHVAAVSIQSQKIKDLEFKLNNTKDEKEISTIKKEISIATQNKVGNLLNAILCVFFMIATLLVIISCIGICLGKIKIPLKETKYIKIDEFQKN52 88 26 245 63 474 Accessory protein (CstA ) Cj0916c ybd D hypothetical protein S MNFKKIKYYYEKAERFFHPLVGLSSYDKYLEHMKQKHPGKIPKTRGEFFKECLDKKYNSGGLNKC55 90 26 254 64 489 Core Cj0915 yci A putative hydrolase I MRDMGEPKLKIVAMPSDTNPAGNIFGGWILSQIDLAGAIAARELSPERVVTISMDKVVFKEPVFIGDIISCYSKVVNVGNTSISVEVEVTAQRVDSQGCTSCINVTSALVTYVSVTRDGKKKPISEELKRIHGFLNA55 90 26 255 64 490 Core Cj0912c cys K cysteine synthase E MKVYEKVSELIGNTPIIHLKKFGINVFAKCEFLNPSHSIKDRAAFEMIKDALDSKKINQDTTIIEATSGNTGISLAMICADLGLKFIAVMPESMSLERRKMITLFGARLELTPANLGMKGAVDKANEILLNTPNSFMVSQFENISNKNAHRKNTALEILRDLDNELDIFVTGFGTGGTISGVGEILKEKLEKVHIVGVEPLNSPLLSKGEAGSHKIQGIGANFIPAILNKEVIDEVITVSNEDAINTAKELAKSGLMVGISSGANVFAASMLAKKFPDKRILTMLNDTAERYLSTDLFA52 88 26 249 64 479 Accessory Cj0911 hyaE putative periplasmic protein S MKKNIILFIVIVAIILGVIFFIKNHQNSYDFILKSDLKEETTLKDFKGDKLIIYFGYTYCPDVCPATLSLVGKALKQINNPKAHLLFISLDPNRDNNLSNTNEWLRYFYPKADALIAKDEKTLQKITKQYNVQYQKIDLNDSFMGYSIAHSNMLYLIDEKGHFYKEISDLNPQEILRELRIFLNSQ55 90 26 255 64 490 Core Cj0909 VY92_09940 putative periplasmic protein S MKKILLLGALFAANLWAVNDIEVKNAFVKQTPPHAQNSAIFLTIFNNTNKDIALISAKSDISEVSELHTHIHKDGKMMMQKIPEIIIKAHSSTELKSGGYHIMLLKLKKPIIKDTKVNLDLKFNNHKTIELKNIDSKEF55 89 26 252 64 486 Core Cj0908 - putative periplasmic protein - MIRNFFIGMSFLGILFLAFYTLYDKKKESIFSLNTCQPLTCDLNLQDCVFSFNKKNIEVSAYPKPIKIFNKTTIKIKNFPHYSNLKIKIYSLNSYIGDIIPKFNIVNGDILINFIGRSITDDSRFRVEFLNNNTPTGFFFDFDVTMQKKFQTGNTH46 80 24 211 35 396 Accessory Cj0905c alr alanine racemase E MSLIKIDQKAYEYNLRHIAKKIGSFQRLICVFKDNAYGHGAKLLAPLAKNLGVSFVAVKSEEEAQEIEEFFENILILSHRPHGNENSRFIYALNDISQVKNYKQDIKIHLKIDTGMHRNGICVENLEHAINLIQGSDLKLTGMFTHFASADEMDGSFFVQKENFQKAKRIVKKYFSNLLFHSYNSAALFRGKIPEDEYCRVGLVQFGYGDSNLKRVLSLYAHRLSQRILQKGQSIGYGGIFTAAKDMEVATYDLGYADGLFRYNGKGELVLGNGKTILGKMSMDSFSCENSGEEICVFKDADIWADFFHTINYEILVKLNPNIQRVLV55 90 26 255 64 490 Core putative amino-acid transport Cj0903c agc S E MKLDIMLDFANKASDIIANKIVPNTDIIMVVLLIVCGLYYSFLTRFVQFRMLSSVFKILTEKNEGHAKEHISPFQALMISTASRVGIGNIAGISLALATGGAGALFWMWVMAFFGGASAFAESTLAQVYKSKDDTGGFKGGPAYYIKKALGSHFFGAFFAFILIITYAYGFNGLQSQTMTSSFKVYYDMFNPNAAVDFASSSWPMIIGIVLTIFGAWMFFSHHTKIGKISSLIVPFMALAYVLLAVIAVLMNFDKIPSVIHMILQSAFDFKAIFGGFAGSALVIGIKRGLFSNEAGMGSAPNAAAAALTSHPAKQGVIQAFSVLIDVVICTSSGLLVLFSMAYLGLGESKIDGGMPLVQEAMREYYGSFGIHFITIAIVLFAITSLIGNYYYAQANVKYLTNSKFVMNLFRITAVAMIFIGSQMNLKLAWNLADLTMAFMATTNIISLLLLGGIVNKVLKDFNTQQKSGIDPKFNASKLGIKNAECWD55 90 25 254 64 488 Core protein putative glutamine transport Cj0902 art M E MIEVKNLQKKYGELEVLKNINTTISKGDVIAIIGPSGGGKSTFLRCINRLELADSGEILINKQNILDKEIDINKIRQKVSMVFQHFNLFANKNVMENLCLTPIKTGILSQEEAIKKAKLLLAKVGLADKENIMPHKLSGGQKQRIAIARSLMMNPDVILFDEPTSALDPEMIGEVLSIMKDVAKEGLTMLVVTHEMGFARNVANRIFFMDKGKIAVDASPKEVFENPSNERLREFLNKVLNH55 90 26 255 64 490 Core ATP-binding protein Cj0886c fts K putative cell division protein D MLAPGMGEWVYKANLFLFGEFGYYYPFSLLILNYLYYKKKYKIENFKRRELFGFSLAFFSALLLFSVFYREFGYILEIVYGFFSIILGRTGSGIFALLLLLFSLVLLFPKFAKEILKIELDFTYLLKIEQAFKSLLMRVFGGENEKEDVGKSEPIAPKLNILQDSIYGNLQINKKGETNNLEQIIKDSNINASKNSIATAKENFEKLKNQILDETIEIDKQSLKESRSFVHEHSQQVRNFAQKASKMSISLDEDFNFISEEEVDMIPERFLKPKKLEDIKQIDTNKNLDEPSYKRKNIEIPVSNQEVKPKIFTKELELRENLIKKEKLEQEYKAYQNEILENKVKQEIKKLEEYDAINSSDIIEGNKYSFNSPKTIKTETEESDKINENKNLDKADNIFEFAPIVEELNHPYIEPTPIKNINEIVIEEKNTLDFIQNTETKIDNKKTNDQEIKLQKAVLAKEIAINQALLREIEQGEVEKPKDFTLPPLDFLANPKEHKQEINESEIDKKIYNLLEKLRRFKIGGDVISTYVGPVVTTFEFRPSADVKVSRILNLQDDLTMALMAKSIRIQAPIPGKDVVGIEVPNDEIQTIYLREILQSEVFKNAKSPLTIALGKDIVGNAFVTDLKKLPHLLIAGTTGSGKSVGINSMLLSLLYRNSPKTLRLMMIDPKMLEFSIYNDIPHLLIPVITDPKKAVNALSNMVAEMERRYRLMADAKTKNIENYNEKMKELGGEELPFIVVIIDELADLMMTAGKDVEFYIGRLAQMARASGIHLIVATQRPSVDVVTGLIKANLPSRISYKVGQKIDSKVILDAMGAESLLGRGDCLFTPPGTSSIVRLHAPFASEFEIEKIVDFLKDQQSVEYDESFLKDQQSVGVTTNESFDGEVDELYEEAKRVILEDGKTSISYLQRRLKIGYNRSANIIEQLTQNGILSEPDAKGQREIL55 90 26 255 64 490 Core Cj0879c - putative periplasmic protein - MKKCILIFFSLYSLSFANIYEKLNDFAYEKKPNKDFKIQEVKLVQFSQENKDCLELLIEVSQVRILNSYNSCQKLSKDESFQKFLNEDFLKLYKNNGYLINENLQNLKNTMQDIMIYYKLRYSFSKDVKDMSKNKNLDILNIDEKDGGTLLYKINNQACVGIELTRHDSRMAMKIYGIENLDKECKLFIQSPSFKDLSYTKKDFKWYYLE38 57 4 140 57 296 Accessory

Seite 2 Table S3 (Cattle)

NCTC13261_00864 - Arylsulfotransferase M MQPVDKNGKKIVCDDYSKCPGYENDNGGFDFTWTQHTGWRIDSKSNKRYIYISVFDNGDARGAEQPVFASQKYSRSVIYKIDQQNKTVEQIWEYGKIVEMNGFLL33 36 1 74 25 169 Accessory NCTC13261_00861 - Arylsulfotransferase M MRLSKTLCMALLAGSTLLAPNVLMAMGGPSGAKIDWQIQGQIGAIKMNPYGLSPLTAIIMDNGYVLSDIKVTIVPKPNGQTISYNVNSKMAKTYGGIPIFGLYPSYLNTVKVSYTKTANGKSQKVIDEIYKITTPGVSIEPSGSTDQRGTPFENVKVLKMDPKFSDRLYLVNNAPGKQSGKGSQSVWNNPVGGAMEWDENSNVFIIDTKGEIRWYFDNDKLMNWDNIYNRGIMMGFHQNKDGALTWGFGQRYVKYDVWEEKFSIANYLLSI48 65 25 118 26 282 Accessory Cj0865 dsb B disulfide oxidoreductase C MKDNCRNFSLSKWQDTRKPWLILIIVTIGLTCIAHFLFQEYLFMEPCEQCVYIRFDMLVMAIGGMIALINPTNNIIKIFSYSLAFYGIWLGLEHCLTLNHIHEVVHSENPFAGVDGCREIPIYPFNLPLHEWAPSWFLPIGECGMDTPVVPENAYNHLNAFQKFFIGTPPDFENGLYSNGWYLIPSLKFINMAICCLIAFLCCFIVLFAMFIAYVLDKNKPNAKIFALAIVILVLVLKFIGEPKNPNQNIASLNHLNQVVLRYS55 90 26 254 64 489 Core thiol:disulfide interchange NCTC13261_00859 dsb A O MKFPVKLARSIVVCAFLAGISASALSEGKEYVILKNPIANADNSLIEIFSYRCTHCYDHHKFNTMGKVKEKLPNLTYKFYPVSSMGDYGKQANEIFTFAAFKDGVNKADPTDKNSLTHKVAEAYFNAYFKKKQRWENGKNPEAFYSVGLKAMNVSKADFENFLKTPEAAELLKSYEIANPISQNYGTPAFVVNGKYQIVPSAIKSPEALIEITKELSKQK55 78 26 255 27 441 Accessory protein DsbA Cj0863c xer H DNA recombinase L MKYPLDCEENFEKSFLFWLAKYVKFKLNSLSNKELKNPQALAEVNFALTKGVKNIEELDALAKKARNAGLSGVNTYFNPLKKVFEYLIFYKLYSLKQIDEELIVEVLASITGALSDASKKNYRIAVINFFDFLDKQNEEDEKAHIFDINLKNWAGIAGSKGVKLPEFMSEEELKKFLDAIENADFKNNTIRNKLIIKIIIFTGIRVSEAINIKMGDISEENDLYIIRIRAKGNKYRVVMIKKELIYDLLKNVSINYMSKDALLFVNKKGTPLTQSYVSRIVEQLLFRAGIRKQKNGAHMLRHTFATLLYKKQKDLILVQEALGHASLNTSRIYTHFDNDKLKLAAQVAKELSDS55 90 26 255 64 490 Core UDP-N-acetylglucosamine Cj0821 glm U M MKTSILILAAGLGTRIKSQKPKVLQELCQKSMILHILKKAFALSDDVSVVLSHQKERVEKEILEYFPKTQILEQDLQNYPGTAGALSGFEPKNERVLILCGDMPLVEQTSLEALLGNNAKLNLAVFKARDPKSYGRVVIKNDSVEKIVEFKDANTQEKEINTCNAGVYVIDSRLLKELLPLIDNNNAAKEYYLTDIVKLAKEKDVMIKAVFVDEDEFMGINDKFELSIAENFMQKKIKKYWMQQGVIFHLPQSTFIGADVEFVGECEVYENVRIEGKSKIINSIIKSSSVIENSIVENSDVGPLAHLRPNCELKNTHIGNFVECKNAKLNTVKAGHLSYLGDCEIDSGTNIGCGTITCNYDGVKKHKTIIGKNVFVGSDTQFIAPVKIEDEVIIAAGSTVSVNVEKGALFINRAEHKMIKDYYYKKFQK55 90 26 255 64 490 Core pyrophosphorylase Cj0794 - hypothetical protein S MADTIRQYYSKFNQIINHSFGNSNKTSFSIEDLNSLPKGYSIHNTDFKFMFQNLDSQTITNFYNTQERYNEAEQLGMFGHINIGLQPLNFTPQSMQTQNLDENSAKYTFNPDMSVYPQNEDGSYSKEALFMSFLKSSGGEALEGGNTTLNPLVKAHIEAMTKESFDGSLASLDDIMTGKVDFASLLKGYAQEGWLDADIYAMEKGVKWQNTSIGYGGAWFDNQFNQAKANGWKASNQSIDSYVSSIMDRLNNLIGQTRV43 81 25 20 44 213 Accessory Cj0814 - hypothetical protein S MSIFSINDNSNYNSILSQAKANKEGKENSKISFANAFLKQNASKLNEIQNANSQTLARSEALNSTNTTNASNNTNLSINNTTQTASPNYNISSEFKNSIYTLKYKQADISNTSTNTAYGYSVDKDGYMGSDFNKAAGLPEDFKIHKSTLDEIYSFNTSFKEHTANDLGVSNYLLYKHRYGRYHKTILFQI42 18 0 102 18 180 Accessory threonine synthase Functional classification-Amino acid Cj0812 thr C E MKLVESRNVNNVSSFKEALINPNAPEGGLYSPLNLPIFEGEKYANLSYKDFALKLIESFGFGEEELFKKALKSYESFDDKNTPISLQKISEKTYINELWHGPTRAFKDMALQPFGVLLSEFSKDKNILIICATSGDTGPATLKSFENVKNVKVACMYPKGGTSGVQELQMRALDKDNLKVFAIDEDFDAAQRTLKELLFSKDFQNEIRALNYELCVANSVNFGRILFQIIYHYYASLKLFNEFLEEVQIIVPSGNFGNALGAFYAKKMGAKISKIKIASNVNNILSEFFNHGVYDLREKSLKKTISPAMDILISSNIERLLFAKFKDKRTKELMNLLKNERYFKLEKEELQSLQEDFEADFCTDEECMQFIKQSKILIDPHTATCFKMLDPLKPSIITSTAEWTKFTPSMIKALYDRDSKNEKEDLKFIAKEFNVQVKDEILALFDLKNSDEKVFEVKNIKKEILDWMQK55 80 26 255 64 480 Accessory biosynthesis-Aspartate family protein Cj0800c - putative ATPase L MALDEKIIAYTENPARELLSVASRTNLSLNELDFSLLAFSTQYRFGDLEWEKISEKELTLFDKDEIFLKNDLQIKQEYKIEIFHGINQSKASQAVKLVANKNLTKIIAQIDFTNLDFHEKLALELLQNIYKKMLKLKFLIGIRIFDFKKNLMSFCNQHKNTPLNKTIQITVAQGIDPIESQDESLILTYKEKTKNYTIDEKRSGIIVVDENEVVLKHAKFKQGKEGKDLNLHTLKVLAANENKVKFSCSSAFKQVEQDGYTEYIALKKGYVVQDGEKFDIANELDFNGVDFKNIGIIRAGLDKNVKINIKFLSEVKDAVNSGVGIECEELNVVGSVGSNTQLNAAKMKIEGTTHSKAKIQAKQAYIKTHRGFVEAEILNIDLLEGGTIKAKEVRIKKSLGGNIQADKIYIENLESNNSCVFFKNTTIERINGDNNKFHAKIKTLDSNYDEEFVILGEQISKLNHKMNKIRQYILSSKNGILSVEKKITELKNQGQNVPIQYEKALKDFSLQNLELNKLQNEEKELLERKKSLQLELINLQKMLFEATFINKSGKWTDMNEIKFSLLEPKEDIFYSSFVNESAKFIGIKKVIQNNQESIEIHKKLDYEEKDIAWLSASKE55 90 26 255 64 490 Core putative Holliday junction ATP- Cj0799c ruv A L MVVGIEGIITKKEPTFIIVKCVSGLSYGIFISLFCSAKIQTQEKHEFFITQIIKEDSNKFYGFLDKDEQKMFEMLLKVNGVGANTAMAVCSSLDVNSFYKALSLSDESVLKKVPGIGPKSAKRIIVELSDTKTKLENVSDDKSEALAALLTLGFKQEKIISVLASAQATGTSELIKEALKKLG55 90 26 255 64 490 Core dependent DNA helicase Cj0798c ddl D-alanine--D-alanine ligase F MKFAILFGGNSYEHEISIVSAVVLKKVINQNLEFIFCDEERRFYHIPSEKMNSKTFSTKAYKKEKELFIQQGGFFSKGFLKENKLECECVINLIHGGDGEDGKIAALFEFYSIKFIGPRLEASVLSFNKELTKLYAKSVGVKTLDYTMLRKGQNSKEKLRFPCIIKPARLGSSIGISIVKDEKDLEYAKDVGFEFDNDLVVEEFKNNIKEYNLAGCMINDEFVFSIIEEPKKKEFLDFEQKYLSFSGHNELIEANLSEELKEKLKDSFKKIYNPLFKGALIRCDFFILDNEIYLNEINPNPGSLANYLFKDFSTTLNALADQISLEKMIKISYNFLHSINGQKGKL55 90 26 255 64 490 Core Cj0794 - hypothetical protein S MITQIIILYFHKQKLIKNSKISFANTFLKQNASKLNEIQSANSQTLVRSEVLNSTNISNTSNSISSKTSSPNYDISSEFKNSIYTLKYKQADISNTSTNTAYGYSVDKDGYMGSDFNKAAGLPEDFKIHKSTLDEIERKAENNSYTSDIKKYLGIDKYYTNIDMAETIKQYYNQFNQIVNHTFNDTNKTSFTETDINSMPKGISELSSDKTIGIMPKNYDKLTITNYYNTQEQYNEAEQLGMFGHINIGLQPLNFTPQSMQTQNLDKDTAIDTFNPDMSVYPQNEDGSYSKEALFMSFLKSTGVSPREGSATLNPIAKSYAEAMAKESFDGSLTSLDDIMTGKVDFASLLKGYAQDGWLDADIYAMEKGVAWQNTSIGYGGAWFDREFNQAKANGWKASNESINSFVNNIMDRLNNLIGQTRV48 76 19 174 22 339 Accessory signal transduction histidine Cj0793 flg S T MNESILKSLDSNEKETLQKGLESLIEQTYVIENEYKTLNENYNSLRAMVDEIIEVLPSALWILDKEKNIILQNQEALKNPKLLSIISLDKIRDELEFEGRFYAVKIIAHNEKTIVSATDISDEKRNERLASMGSVAAHLAHEIRNPIGSISLLASTLFARSELKNKHIVLEIQKAIARVERIVNSTLLFTKGVHINALNFNLLELKEECESAINSYNFTSQIDFEISFLDKQICADKALLGLVLQNLIYNAIDAIEESECEKPMIKILASCDNEKICIRVYDNGCEIKDEKLVFEAFKTTKLKGNGLGLSLSKEIINAHKGELSFQSDPKNFYFTLPLV55 90 26 237 61 469 Accessory kinase Cj0792 - hypothetical protein S MLYKRKNIKFKNFVDLHKNLSLSKLFDFYSVFEGFEKLNILNFEDDVFTNIERILLDDYLKIKSYFALDETSSYALTLLAKNNRKRFSINRKIQHFKALSTLKYLLETGIIKLEYSKEAKKIKDKRQKIKKELRSYVVQDKIIFSNHFTRFFFYFLKPNEKLILQNRYKEVLECIKEKFELYQSFCFEQLSRELLGKKFNINGVQSYWDKNLELDLYYQDENLCFVGEVKFKNKKICKNILNLLKSKAKSLNLAPNYYIIISKNGFSKEFDKICEQNLLLLDLNDFKILLEE55 90 26 250 62 483 Accessory Cj0791c csd A putative aminotransferase E MQISDLKKELILKKGILHFDFTASALALKCVEKEISKILPTYANTHSDSSLNSFKTQQTYEQARKDIKKSLSLDENFALIACGTGSSSAIKKFQELIGIYIPPLVKERYFTQIDKNTLPLVIVGPYEHHSNELSFREGLCECIRIPLDKNGEIDFDFLEKTLQKNKKRKIIASFSLASNVTGILSDYKRISEMVRKFKGIVAFDASSFIPYKNISCQYYDALFISSHKLIGGIGGSGLLAIKKDLCGNKPSFAAGGTVGYVSRTSQYYLCNEESLEEGGTPGILQLIRASLAFKIKDSIGVKNIEKKEEILKDYFFEKLKTIPNLILYAKNLKTRLPIFAFNIKGISPFDIAYELSKKYRIETRAGCACAGPYGHDLLDLKDNQKLKTKPGWLRISLHYTHEKEDIDYFFNALNKTIVKLSH55 90 26 255 63 489 Core periplasmic nitrate reductase Cj0783 nap B small subunit (cytochrome C- C MKKKLVLLGSAAVVFFAACAMNSGVSSEQIGLRKASLENENKVNLVEANFTTLQPGESTRFERSYENAPPLIPHAIEDLLPITKDNNMCLSCHDKAIAADAGATPLPASHYYDFRHNKTTGDMISDSRFNCTQCHVPQSDAKPLVGNSFKPEFKNEQLKSRSNLIDVINEGVK55 90 26 255 64 490 Core type protein) Cj0780 nap A periplasmic nitrate reductase C MNRRDFIKNTAIASAASVAGLSVPSSMLGAQEEDWKWDKAVCRFCGTGCGIMIARKDGKIVATKGDPAAPVNRGLNCIKGYFNAKIMYGEDRLVMPLLRMNEKGEFDKKGKFQQVSWQRAFDEMEKQFKKAYNELGVTGIGIFGSGQYTIQEGYAALKLAKAGFRTNNIDPNARHCMASAVVGFMQTFGVDEPSGCYDDIELTDTIITWGANMAEMHPILWSRVSDRKLSNLDKVKVVNLSTFSNRTSNIADIEIIFKPNTDLAIWNYIAREIVYNHPEAMDMKFIKDHCVFATGYADIGYGMRNNPNHPKFKESEKDTVEKENVITLDDEEATSLSYLGVKAGDKFEMKHQGVADKNWEISFDEFKKGLAPYTLEYTARVAKGDDNESLEDFKKKLQELANLYIEKNRKVVSFWTMGFNQHTRGSWVNEQAYMVHFLLGKQAKPGSGAFSLTGQPSACGTAREVGTFSHRLPADMVVANPKHREISEKIWKVPAKTINPKPGSPYLNIMRDLEDGKIKFAWVQVNNPWQNTANANHWIAAAREMDNFIVVSDCYPGISAKVADLILPSAMIYEKWGAYGNAERRTQHWKQQVLPVGAAMSDTWQILEFAKRFKLKEVWKEQKVDNKLTLPSVLEEAKVMGYSEDDTLFDVLFANKEAKSFNPNDAIAKGFDNTDVKGDERKIQGSDGKEFAGYGFFVQKYLWEEYRKFGLGHGHDLADFDTYHKVRGLRWPVVNGKETQWRFNTKFDYYAKKAAPNSDFAFYGDFNKMLTNGDLIAPKDEKEHSIKNKAKIFFRPFMKAPERPSKEYPFWLATGRVLEHWHSGTMTMRVPELYRAVPEALCYMSEKDGEKLGLNQGDLVWVESRRGKVKARVDMRGRNKPPVGLVYVPWFDENVYINKVTLDATCPLSKQTDFKKCAVKIYKA55 90 26 254 64 489 Core putative ATP-dependent DNA Cj0777 rep L MPLSKLNNEQYLAATADFGHNLVIASAGTGKTSTIVARISYLLSKGVAPQKIMLLTFTNKASKEMIGRLGKFFDKNITSKILAGTFHSTAYTLLRNADKNIALKQASELKTLLKSVYEKRTFRHLSDIKPYQSSYLYDLYSLFQNKAHNQDFYTWFCQNYEDQSIYAEIYEDILKEYDNEKKRFNYVDFNDLLINLKELLKEEKYEFDEILVDEYQDTNTLQSSLIEAFHSKSLFCVGDYDQSIYAFNGADINIIGGFKDRFKDAKIFSLNKNYRSSRSILALANKVILNNERLYPKELIVTRNDEFKAPSLLTFEELFDQYQNIAKMILTSGVSLEEIAVIFRNNSSADGVEVALREQGIASVRKGSGSFFESLEVKAFSSMLALVVNPKDIMAFIHLVQYTKGVGGVLAKEIFDALLKLGHGNLIKGFLDPDKNVNLQNHQKRNYQLGLFADLEELASETRFKFESEFDAHPILKLSKINDLCARNLEKIYLFLKKAMELKHSLTLVNLICENSFYREICEELATKRATNKAGQVDLLRKSENLEKIETKFNVLKELTKNYSDIYKYYNFLTLGASEMSSGKGVNLLSVHASKGLEFDLVFVIDLAQGRFPNQKLMGMGGSLEEERRLFYVAVTRAKNILYLSYAKYDKNKKTSFAPSRFLIEAGLCKGELTID55 90 26 255 64 490 Core helicase Cj0776c - putative periplasmic protein - MNLKIFSIIVGILIAVIVILGGTYYYLFEYSKPKNYTLNTNTYTEQKSYTNNYDNPYSPSIQTNNSSSNVNTNNNTIQKQETNPLLDENQSLNNDTFNTSISENNQSLNNDTNTSNNINTNENKQILDTDKGKLKQENKQAKIEALKKEISKQQKILERERAVKKELQSNKSNKNKYLNTAREYLNIGKNSRLEPELSTENMKVYILDGKFLSQYRINLLKDMLSVIQDNAKDYYLSVFVKMLPKEEMKLTIYNKEIIFSDMKKAYKYISLDRLSPYLNNPKELNEHVAREEILERLKLQIKKDGKGSDFSKHIKSLKTGLNTAQYFFPFCEIIEISSIK55 90 26 255 64 490 Core Cj0775c val S valyl-tRNA synthetase J MYDKNLEKEYYQICEERGYFEIDGNKTIQEKDKNFCIMMPPPNVTGVLHIGHALTFTLQDIMTRYKRMDGYKVLYQPGLDHAGIATQNVVEKQLLAQGIKKEELGREKFIEKVWEWKEQSGGKILDQMRTLGITPAWSRLRFTMDEGLANAVKKAFVELYDKRLIVRGNYMINWCTHDGALSDIEVEYKKNKGKLYHIKYFLKDSDEFLVVATTRPETFFGDTAVMVHPDDERYTKFVGKEVILPISKKAIKIIADEHVEKEFGTGVVKVTPAHDMNDYEVGLRYNLEFISVFDEKGILNEHCLEFQGLERLEAREKIVAKLESLGFIEKIEEHNNQVGYCYRCNNLVEPYISKQWFVKKEIAQESIEKVALGESKFYPNHWINSFNAWMKDLRDWCISRQLWWGHQIPVYYCECSHEWASQHTPKACPKCQSQNFKQDEDVLDTWFSSGLWAMSTLGWGNENWGKDKIWSEKDLKDFYPNSLLITGFDILFFWVARMMFQSTNALHQLPFKDIYLHALVKDEQGRKMSKSLGNVIDPNESIKEYSADILRFTLALLAIQGRDIKLSNDKLLQVRNFTNKIYNATNYLLLNESKFEDLENITLHSELAKYIYAKFQTCVKDVRENLDNYRFNDAANTLYKFFWDDFCDWGIELSKAEKSSVKELGSIFKEALKLLNPFMPFISEYLYHKLSDTELKTSPSIMISKYPNFKEQDKNIEKIFSLLIESIVGIRRAKSLIDLGNSKIEKAYIKFNDKKIKDEIKAYMNFIIMLAKCEQIEFSEEKLPKAICDVSENLEIFITLENVDLSGILTRLENQKNKLEKESFKLNSMLSNEKFIANAPKEVVEQNKEALENLKIQLEKISVELQNLRG55 90 26 255 64 490 Core putative NLPA family Cj0772c met Q P MKIKSLFIASILTLSLNANALETITVAATPVPHAEILEQVKPDLEKQGYKLEIKEFTDYVLPNLAVDNGEADANFFQHTPYLEEFNKNKGTKLIKVAAIHIEPMAVYSKKYKSLDDIKEGVKIAIPNDPTNESRALDIITKKGLVKFKNKALKTPLDIIDNPKKIKFIELKPAQLPRALDDVDFAVINSNYALSANLNPAKDSVFIEDKESPYANILVVRVGHENDPKIKALIQALQSDKIKQFIIEKYNGSVLPAF55 90 26 255 64 490 Core lipoprotein putative NLPA family Cj0771c met Q M MNLFKIIILACILNLSSLFAQNITIGATPNPFGSLLELMKDDFKNKGYELKIVEFSDYILPNRALEEKELDANLYQHKPFLEEYNLKKGSNLIATTPVLIAPVGVYSKKIKNLENLKEGARVAIPNDATNESRALELLEKAKLIELNKNTLKTPLDINKNPKKLKFIELKAAQLPRALDDVDIAIINSNFALGAGLNPSKDTIFREDKNSPYVNYVVVRSEGKNSEKTKVIDEILRSDKFKAIINEHYKDILIPAF55 90 26 255 64 490 Core lipoprotein Cj0763c cys E serine acetyltransferase E MNFWGIIKEDFSQPKAQDPAFNSCIELFFNYPGMWAIVNYRFAHFFYIRNFKRIARMISGISQFLTGVDLHPGAELGRRVFIDHANGVVIGQTAIIEDDVLIYQGVTLGGTSLEKGTKRHPTIKKGVIIGSGAKVLGNITIGENAKIGSNAVVVKDVGANLTAVGIPAYIIEERKNKNIRAIDANCDDKLEKLEKKILELENLILKQHESQK55 90 26 255 64 490 Core Cj0762c asp C aspartate aminotransferase E MLTKRSQVLEESITLAITALANELKAKGEDIISFSAGEPDFDTPQTIKNAAISAIEKGCGKYTAIAGIPEVLKAIQTKFKKDNNLDYETNEIISNVGAKHSLFECIECLVEKDDEVIIPSPYWVSYPEMVKFAGGKPVFIEGLEENGFKITAEQLKKAITAKTKVLMLNSPSNPVGSIYSKEELTQIAKVLEGTQITVLSDEMYEKLRYDGFDFVAFASVSKDALKRTVTINGLSKCGAMPGWRFGYMASKNKALISAVKRLQGQSTSNICSITQHAAIPALNGECDKDIEKMRQAFEKRRNLALDILKQIPNISVYKPEGAFYLFVNIQKIEKDSMKFCQKLLEQEKVAVVPGVGFGMDGYFRLSYATSDELIKKGLERIANFIKNYK55 90 26 255 64 490 Core Cj0757 hrc A putative heat shock regulator K MKSRDKKDLILESIIQTYLLDNAPIGSNELNSNLCIPASTIRVYLKRLSDEGLITQLHISSGRIPTILTMQNYWQSFWEKEQDKNIHIKNESFLKELSKEFEIYCLVYGGRSLVLKEVLDLNTKFIVLDFEDEELVLKYEKEAWNFLQSLIGLDLSSIEKIALRVHFIDLVEKIASLRQNLICYRSNEERAYQIYQNDEFVKLLDCQIHRHFKESLEFEPLFKEGFMGLKVDAQFLGEDVNIILAGSVYTDYKKILQYIKEAA36 74 0 195 15 320 Accessory Cj0755 cfr A ferric receptor CfrA P MKKLCLSVCAIGLLASNAISQNVELDSSIISASGFAQDIKEAPATINVITKKELQSKPYRDIAEAIADIPGVDLYASKGKTGSYNITMRGITGYTLVLIDGRRQGIGGEVGPNGFNEISNSLLPPISSIERIEVIKGPMSTLYGSEALGGVVNIITKKVSDKWETSVSLDALLNENKDWGNTYGTSIYSNGPLMNDKLGLTLRFREFYRQQSNVEFTNGSGQRVPGDQAQSPTKANNFNIGTRVSYLANDYNTFIFDIDFSRNHYDNKKGQLGTITQPGDTKDSLIGGYTDIMEVDKFVTYLSHEGVYENFSITSGLQYNRVSNNGREVVGQANQPFLGQNRDIVAEDIILDTKSVIPLGQSHILSVGGEYRLEKMQDKIANPTNFDQYLLAIFAEDEYSIKDNLRFTFGARYNHHEIFGNNVSPRAYLVYNPTDELTFKGGISTGFRTPYANRLINGTYNYSGQGKFSIYGNPDLKEETSLNYEIAAIYNNDLFYVSATGFLTNFKDKISTQRYDKNNMIPGIGTCNTDRCFRAINHGKVEYKGVELGAGISPLDNLNVNFAYTYLDTEVKEAQDKTAIGKPEQDSLKHNIMLKTEYSFYNKFTPWIKGEWQIDRYMGDTNINREYYKDIFLASMGVRYDINKQWSINAAIYNLFDKSFTNSWESYEITNKNPTKTAWVNTYNRIEEGRRMYISINGSF26 55 0 144 1 226 Accessory Cj0753c ton B energy transducer TonB M MKAFISNHKNQSSLITLFVFTPLFFVFLYYKNFLHIQPNDTIKENKFNIAIKHFVQNSSDIKPTQPIQTIQEPSNVQPKEPVQEIKKIKPRKEKPIAKPKKIIPPANAKAISQPKKDTNMQQQTPQASSYQSVSLTSNSELLKEIKSAIDEALIYPRQARKMRMSGEVLVEFTWTKEKKLENLKILKPSKYDFLNKSALETIRIASKKFPQYEKTFHIKIPLVYKLS36 73 0 192 12 313 Accessory Cj0752 - ISCco1, transposase orfB - MRYHRDLPNTYKFNQITIIKNHNKYYLAFSIIYDESNVSLISSKDFDIKKAVDIDLNINEITLSSGELIATNSKLLSRAEY29 65 0 176 12 282 Accessory DNA polymerase III, alpha Cj0718 dna E L MSQFTHLHLHTEYSLLDGANKLKELALTLKEQGATSVAMTDHGNMFGAIDFYQTMKAQGLKPIIGMEAYLHNHDELDDKSSRQRFHLCLYAKNEIGYQNLMYLSSQSYIKGLYYYPRINKKLLEDHSEGLICSSACLQGEVNWHLNTYSERNVRFGAKGYEAAKEVALWYKKVFKDDFYFEIMRHGIGDQRMIDDDIIRLSKELNIKIIATNDTHYTFKERAAAHEVFMCIAMGKKLNDPDRMRHSVHEFYVKSPEQMSELFADIPEAIENTQEIAQKCNLELNLGNPTPPNFKFTREYAKDHNIILPEETKEFSFDNDDMVFEELCKKGLEERLKFIDESKHEEYKQRLEVEINIIKNMKFSGYMLIVHDFIKVAKDKGIPVGPGRGSAAGSLVSYCLRITDLDPIPYSLLFERFLNPERVSMPDIDVDFCQDRRAEVIDYVIDKYGADKVAQVITFGKLLAKGVIRDVARVCDMSIQDADELAKLVPEELKITLDAAYEKEPKIKEFIDRHPKGLEVWEYARALEGLNRNAGMHAAGVVISNESLWKKTPLFRQSKNDERHLVTQYSKDHLEDVDLIKFDFLGLKTLTVINNAIKLIKKRYNKDIIWETIDVNDSKVYKTIQSGNTLGIFQIESGGMQSLNARLKPERFEDIIAVLALYRPGPMESGMLDDFIDRKHGLKSIEYPFDSLEKVLEPTYGVIVYQEQVMQIVQIIGGFSLGGADVVRRAMGKKDPEKMKKLKTDFADGAEKQGYDRAKAEDLWELIVKFAGYGFNKSHSAAYALITFQTAYLKTYYPSEFMAALLTSEENNVDKIAVYIDEMKKMNIKLLPPSVNKAIREFSALEQDGKDAIIYGLGAIKSVGIPAVENLLEARQDGEFKDINDFLSKIDPTKINRRTLESLIKAGAFDEFGFTRKALFDNMENLSEASRKMAEVRKNAASSLFGEEELTSGVQVNFTPKNEEFEVMEKLGYEKEILGIYVSGHPLDRFYEQINAIDYVKSLDFEGLKNNGEILSIGKIEDFKS55 90 26 255 64 490 Core chain Cj0717 spx A putative ArsC family protein P MKLYGIKNCNSVKKAMDALTQKGIVFDFMDIKKINQDILYTWLKQKSFEELINTAGLTSKKLGLNKEKVKNLNEKELEKIVLENPSCIKRPIIEYEQNIYIGKEYEKML55 90 26 255 64 490 Core

Seite 3 Table S3 (Cattle)

putative phospho-2-dehydro-3- Cj0716 aro F E MWTKNSWKNYPIKQQPIYPDQEEMNRVLARLEKLPPLVFAGEVRNLQKSLARVCKKEAFLLQGGDCAESFENFGAVNIRDMFKILLQMAIVLTFAGGCPVVKIGRIAGQFAKPRSSDFEELNGISLPSYRGDIINGFEFSEQARIPDPHRMLEAYYQSATTLNLLRGFAKGGLADLHEVHRWNLGFLKKSELHKQYTDISEKISQALAFMEACGINTSNTPSLREVSVYTSHEALLLPYEEALTRVDSLSGEIYDCSAHMLWIGERTRALDEAHVHFLRGVKNPLGVKIGPSASADDIIALANVLNPNNEEGRLNIIIRMGADKIINNLPKIFSKLKSEGLNLVYSIDPMHGNTVKAGNFKTREFDKIMQEVRSFFEIAISEGVYPGGVHLEMTGKDVTECTGGASNVTAQSLEDRYETQCDPRLNADQALELAFLIADLVKKARK55 90 26 255 64 490 Core deoxyheptonate aldolase transthyretin-like periplasmic Cj0715 ura H S MFSIKKTLLILASVPMFLSATEYQLSTHVLDITSGQPAPKVKVELYKLEANQQWKKVSEEFTEENGRIGDLLPYEKAENRAFGIYKLKFFTKDYYTSHKINTFYPFVEVSFELSKDQKHYHVPITLSPFGYSTYRGS55 90 26 255 64 490 Core protein Cj0714 rpl S 50S ribosomal protein L19 J MKNKYIEQFEAKQIEGKNVPDFRAGDTLKLAIRIKEGDKTRIQNFEGICIARRGNGVSETFIVRKMGANNVGVERIFPIYSESLESITVLRRGRVRRARLFYLRDRRGKAARIKELKK55 90 26 255 64 490 Core tRNA (guanine-N1)- Cj0713 trm D J MKFSFVSLFPNLMEFYFQDSILARAKEKKLFKLNFYNPRDFSKNSYHKVDDYKIGGGAGLLMQAEPMYEVLRSIQEKKENPYFIFLNPSGKTFNQKDAKRLSKKEHIVFVCGRYEGIDERVLEIFANEVFSIGDFILTGGELPALVMCDAILRNVNGVLGNMESLEEESFENNLLEAPAFSKPFIFEKKNKKFYTPSEFLKGNHARIASLKTTLASCKTKFFRPDLFLEHERKK55 90 26 255 64 490 Core methyltransferase putative 16S rRNA processing Cj0712 rim M J MSEKDFVQVAKLGKTVGLKGYVKLHNLSDFSSQFKKDATFFIKNTKEMLKIKHYNASNSTVLFENYEDIEKAKELINLILFQSIEKSRQTCKLKKDEFFYFDILECEVFEEDKRLGKVIDILETGASYLFEIQSDEKWVEKKYPKIFFIPYLDKFVKNIDIEKRQIFCTQDAFLILENS55 89 26 254 63 487 Core protein Cj0710 rps P 30S ribosomal protein S16 J MTVIRLTRMGRTKRPFYRIVVTDSRKRRDGGWIESIGYYNPMVEPEVIKVDAERLAYWKSVGAKLSDKVASITSK55 90 26 255 64 490 Core signal recognition particle Cj0709 ffh U MFELVSESFKSAINKLRFVDDEKALKNALETLKKALLKADVHHKVTKELLTLIEEDVKQNGIGQKQFLNAIKVNLENILSVNGKNQGFVFASKPPTVVLMAGLQGGGKTTSTIKLANYLKLRNKKVLVAACDLQRLAAVEQLRQLCEANEIELFFIENEKDPIRVAKEALKKAESSMVDVLLVDTAGRLAIDEALMNELKVVKDVLNPDEIFYVADAMSGQDGVKTAASFNEVLGISGVILSKFDADTKGGVALGIAKQIGIPLRFIGVGEKVADLEVFIPDRIVSRIMGEGDLATLAEKTAAIIDEKEAKKLNQKIKKGEFNFNDFLNQMESIKKLGSMKSLIGMIPGLGGMANAVKDIDLDNSKEIIRIKAMISSMTPKERENPDLLNNARKRRIAEGAGLSQVEVNRFLKQFSNAAKLAKRFSGKKGMESLTQMMSQARRQF55 90 26 255 64 490 Core protein OORD subunit of 2- Cj0535 oor D oxoglutarate:acceptor C MSMIAPKDTPVWVDEHRCKACNICVSYCPAGVLAMRDDVHAVLGQMIEVVHPESCIGCTECETHCPDFAIMVAKRDEFKFAKLTAEAKDRAVAVKNNKYKKLA55 90 26 255 64 490 Core oxidoreductase succinyl-coA synthetase alpha Cj0534 suc D C MSILVNKNTKVIVQGFTGKEATFHAEQCMAYGTNIVGGVTPHKGGQTHLGKPVFDTVADAVKATKADVSLIFVPAFAVGDSVIEAADAGIKLAVVITEHTPVKDMMFAKQYANKKGMKIIGPNCPGIITSEECKLGIMPGFIFKKGCVGLISKSGTLTYEAANQVVQGGYGISTAVGIGGDPIIGLAYKELLSEFQKDDETKAIIMIGEIGGSLEVEAAKFIKENISKPVVAFIAGATAPKGKRMGHAGAIVGSADESAAAKKEALKSYGIHVVDSPALIGEEIQKILD55 90 26 255 64 490 Core chain Cj0532 mdh malate dehydrogenase C MKITVIGAGNVGSSVAYALILREIANEIVLVDINEDLLYAKELELTQSIAALNLNIDLLCTKDYAHTKNSDIVLFSAGFARKDGQSREELLQLNTSIMLDCAKKIKDFTEDPLFIILTNPVDFLLNTLYESGIFSSKKIIAMAGVLDNARFKYELAKKLNVKMSRVDTRLIGFHNDDMVLVKSYASVKNKNISEFLNEEEFEDLENEVKTGGAKVIKHLKTSAYLAPASACIRMLESIRSGEFLPMSVILHGEFGVQNKALGVMARLGLEGVIEIMKMDLSLQEKDKLEKSLIKYQYKGE55 90 26 255 64 490 Core putative methyltransferase Cj0495 - S MSDLITLAQLSQGYRYNSDSLILADFILKQGIKGAVFDVGAGCGIIGILLKKNIANLSLSLIDIQKENIKLIEKNLKSNQIQGDIFYDDFNQFQSIKKFDFIVCNPPFYRQGAYKSEDQHKAISKFQEFLPLHSFLTKANSMLKPNGTLYFCYEALALDEICFILKDMKMKITKLCFVHTHQNKKARLVLIQVKKGSKSPCEILPPFFVYENEILSKQMQEIHLRFRLKSYDI55 90 26 255 64 490 Core domain protein Cj0494 - putative exporting protein - MIKIAFFITFVISFLTAQSPVNFKEDNNITKEQNIFKEQPPKRIKIPTH46 53 25 72 25 221 Accessory Cj0493 fus A elongation factor G J MSRNTPLKKVRNIGIAAHIDAGKTTTSERILFFTGMSHKIGEVHDGAATMDWMEQEKERGITITSAATTCFWKDHQINLIDTPGHVDFTIEVERSMRVLDGAVAVFCSVGGVQPQSETVWRQANKYGVPRIVFVNKMDRIGANFYNVEDQIRNRLKANPVPLQIPIGAEDNFKGVIDLVTMKALVWEDDTKPTDYVEKEIPAELKEKAEEYRTKMIEAVSETSDELMEKYLGGEELSLEEIKTGIKAGCLSLSIVPMLCGTAFKNKGVQPLLDAVVAYLPAPDEVANIKGEYEDGTEVSVKSTDDGEFAGLAFKIMTDPFVGQLTFVRVYRGCLESGSYAYNSTKDKKERIGRLLKMHSNKREEIKVLYAGEIGAVVGLKDTLTGDTLASEKDKVILERMDFPDPVISVAVEPKTKADQEKMSIALNKLAQEDPSFRVSTDEESGQTIISGMGELHLEIIVDRMLREFKVEAEVGQPQVAYRETIRKTVEQEYKYAKQSGGRGQYGHVFLRLEPLEPGSGYEFVNDIKGGVIPKEYIPAVDKGVQEALQNGVLAGYPVEDVKVTVYDGSYHEVDSSEMAFKLAASMGFKEGARKAGAVILEPMMKVEVETPEDYMGDVIGDLNKRRGQVNSMDERGGNKIITAFCPLAEMFGYSTDLRSQTQGRATYSMEFDHYDEVPKNVADEIIKKRNG55 90 26 255 64 490 Core Cj0492 rps G 30S ribosomal protein S7 J MRRRKAPVREVLPDPIYGNKVITKFINSLMYDGKKSTATTIMYGALEAIDKKGGEKKGIDIFNDAIENIKPLLEVKSRRVGGATYQVPVEVRPARQQALAIRWIISFARKRSERTMIDKLAAELLDAANSKGASFKKKEDTYKMAEANKAFAHYRW55 90 26 255 64 490 Core Cj0491 rps L 30S ribosomal protein S12 J MPTINQLVRKERKKVLEKSKSPALKNCPQRRGVCTRVYTTTPKKPNSALRKVAKVRLTSGFEVISYIGGEGHNLQEHSIVLVRGGRVKDLPGVKYHIVRGALDTAGVAKRTVSRSKYGAKRPKAGAAK55 90 26 255 64 490 Core DNA-directed RNA polymerase Cj0479 rpo C K MSKFKVIEIKEDARPRDFEAFQLRLASPEKIKSWSYGEVKKPETINYRTLKPERDGLFCAKIFGPIRDYECLCGKYKKMRFKGVKCEKCGVEVANSKVRRSRMGHIELVTPVAHIWYVNSLPSRIGTLLGVKMKDLERVLYYEAYIVENPGDAFYDNESTKKVEYCDVLNEEQYQNLMQRYENSGFKARMGGEVVRDLLANLDLVALLNQLKEEMAATNSEAKKKTIIKRLKVVENFLNSNLNANTDSDEAVPNRPEWMMITNLPVLPPDLRPLVALDGGKFAVSDVNDLYRRVINRNTRLKKLMELDAPEIIIRNEKRMLQEAVDALFDNGRRANAVKGANKRPLKSLSEIIKGKQGRFRQNLLGKRVDFSGRSVIVVGPKLRMDQCGLPKKMALELFKPHLLAKLEEKGYATTVKQAKKMIENKTNEVWECLEEVVKGHPVMLNRAPTLHKLSIQAFHPVLVEGKAIQLHPLVCAAFNADFDGDQMAVHVPLSQEAIAECKVLMLSSMNILLPASGKSVTVPSQDMVLGIYYLSLEKAGAKGSHKICTGIDEVMMALESKCLDIHASIQTMVDGRKITTTAGRLIIKSILPDFVPENSWNKVLKKKDIAALVDYVYKQGGLEITASFLDRLKNLGFEYATKAGISISIADIIVPNDKQKAIDEAKKQVREIQNSYNLGLITSGERYNKIIDIWKSTNNVLSKEMMKLVEKDKEGFNSIYMMADSGARGSAAQISQLAAMRGLMTKPDGSIIETPIISNFREGLNVLEYFISTHGARKGLADTALKTANAGYLTRKLIDVAQNVKITIEDCGTHEGVEINEITADSSIIETLEERILGRVLAEDVIDPITNSVLFAEGTLMDEEKAKILGESGIKSVNIRTPITCKAKKGICAKCYGINLGEGKLVKPGEAVGIISAQSIGEPGTQLTLRTFHSGGTASTDLQDRQVSAQKEGFIRFYNLKTYKNKEGKNIVANRRNAAILLVEPKIKTPFKGVINIENIHEDVIVSIKDKKQEVKYILRKYD55 90 26 255 64 490 Core beta' chain DNA-directed RNA polymerase Cj0478 rpo B K MLDNKLGNRLRVDFSNISKQIEIPNLLQLQKKSFDYFLNLDNGESGIEKVFKSIFPIHDPQNRLSLEYVSSEIGKPKYTIRECMERGLTYSVNLKMKIRLTLHEKDEKTGEKVGVKDIKEQEIYIREIPLMTDRVSFIINGVERVVVNQLHRSPGVIFKEEESSTVANKLVYTAQIIPDRGSWLYFEYDAKDVLYVRINKRRKVPVTMLFRALGYKKQDIIKLFYPIQTIHVKKDKFLTEFNPNDFMDRIEYDIKDEKGKIVHQAGKRLTKKKAEQLIKDGLKWIEYPVEILLNRYLANPIIDKESGEVLFDSLTLLDESKLAKIKEQKSFDIANDLANGVDAAIINSFAQDGETLKLLKQSENIDDENDLAAIRIYKVMRPGEPVVKDAAKAFVNDLFFNPERYDLTKVGRMKMNHKLGLEVPEYVTVLTNEDIIKTAKYLIKVKNGKGHIDDRDHLGNRRIRSIGELLANELHLGLAKMQKAIRDKFTSLNADLDKVMPYDLINPKMITTTIIEFFTGGQLSQFMDQTNPLSEVTHKRRLSALGEGGLVKERAGFEVRDVHATHYGRICPVETPEGQNIGLINTLSTYAKVNELGFVEAPYRKVVNGKVTNEVVYLTATQEEGLFIAPASTKVDAKGNIVEEFVEARQDGETILARREEVQLIDLCSGMVVGVAASLIPFLEHDDANRALMGSNMQRQAVPLLTASAPIVGTGMEQIIARDAWEAVKAKRGGVVEKVDNKSIFILGEDDKGPFIDHYTMEKNLRTNQNTNYIQHPIVKKGDIVKAGQIIADGPSMDQGELAIGKNALIAFMPWNGYNYEDAIVVSERIIREDTFTSVHIYEKEIEARELKDGIEEITKDIPNVKEEDVAHLDESGIAKIGTHIKPGMILVGKVSPKGEVKPTPEERLLRAIFGEKAGHVVNKSLYATASLEGVVVDVKIFTKKGYEKDDRAIKSYDKEKMALEKEHHDRLLMMDREEMLRVCALLSKAPLNSDQKIGDKNYKKGQTADISELEKINRFTLTT55 90 26 255 64 490 Core beta chain Cj0464 rec G ATP-dependent DNA helicase L MKIKESDFEFFKKLKIRSAIDLALLLPKKIENLNPSKNPKENEICTQKITIKSVSSRKNQLFGLGFCEEWQENISFVFFHPRAWHFGICKVGKGLIFNAKLSRFNHTWQFNNPKILTSFEGFSPKYQILGLKDTKIAAFIHKYLNYENLKESGIEDKYIHFLLNLHAYDEKSFFMFENLQNFSKDLKYIEIYNFLKRLKAKKTHFKAHQINVFNIANWLKDLPFSLTKDQLNALKDIEKDLHSKEARRRVIMGDVGCGKTLVLLGAALMVYPKQAILMAPTSILAHQLYEEAKKFLPDFMNILFIKGGKKEKDLEQNIQKANLIIGTHALIHLESHNAVLVMIDEQHRFGSAQREKIHSLSKQEFAPHFIQFSATPIPRTLSMIQSELLNFSFIKQMPFKKDITTYCIQNEGFSKLSEKIKEEIAKNHQIIIIYPLVSASDNIPYLSLEQAKEYWQSHYEKVFVTHGKDKQKDEILERFRDEGNILLSTTVVEVGISLPRLSMIVIVGAERLGLATLHQLRGRVGRVGLKSTCYLYTKLKEIPSRLKEFASTLDGFKIAELDLKNRLSGDLLDGFMQHGNEFKFFDFSKDEEILEKAKKDLAKKLPN55 89 26 250 63 483 Accessory Cj0463 ymx G zinc protease-like protein S MQYLESRGVKIPFIFEKKSDFPIVVLKLVFRNCARSYDEIAGLAKMFSRILNEGVDDKFFKDLEFRAINLEASSGFESLEINLSCLKENFDFALKSLEKLLLKPRIEEKTLQKLKINALGELASKNSDFDYLAKNLLNAQIFKCKEFQSPNDGDEKSIETLSLKDLQNFYKNFIHLSDLVVILGGDLEEKQAKEDLLKLLSKLQIGKKNTPKKYELSKNIKDEILVRPESEQAYIYFATPFFADFKDKDLYLAKIALFVLGQGGFGSRIMEEIRVKRGLAYSAYAMLDMNMSFSRVFGYLQTKNESAKEAKKIVKELFEDFIKNGMTQNELDQAKNFLIGSTPLRYESLSKRLSMAFNEFYQGLNLGYYKEELKLMEKVKLETINAYIKKHQELLNISFASIQNEN55 90 26 255 64 490 Core putative radical SAM domain Cj0462 mqn C H MKRLDKKEALDLLHHASLTELGEMAYKRKLELHPEKITTFVVDRNINYTNVCCIDCSFCAFYRHHKEDDAYILSFEEIGKKIEELEAIGGTQILFQGGVHPKLKIEWYEELVSWIKEHYPNIAVHGFSAVEIAYIAKASKISITEVLKRLQAKGLFSIPGAGAEVLSDRVRDIIAPNKCDTATWLEVHRQAHKIGMKSTATMMFGTVENDEEIIDHFEHLRKLQDETGGFRAFILWSFQSDNTALIQKHPEIMKQSSNKYLRLLALARLYLDNFKNLQSSWVTQGSLIGQLALKFGANDLGSTMMEENVVSAAGASYRMNQDEMIRLIRSLGENPAKRNTAYEILERF55 90 26 255 64 490 Core protein putative MFS (Major Cj0461c bac E Facilitator Superfamily) EGP MNYIELLKNNKNIRILASVQFIVYFGAWFSQTGVFTLLVELNAPTWATATSAMLAFLPGVLLAPINGVIVEKNKPKKLLLSMISIELISIFCLIFVTSLSMLWLLFILIFIRLCVASIYFQAEMSLLAKILTPQELKLANEMHSVIWAISYTAGMASAGIFIYFLGVKTAFLFDCMLILIGISFLVRLSIPDFHQKTQSRFFTMIKEGFFYVLNNKIIFHLILLHAFIGLTAYETLVTLLAQHQYKEVLSAALVIGFLNAVRACSLAIGPMVLSKFINDKNLFYMYLGQGLGIILWALTQFNFYISFLGLIGAGFFTSALWAYTYTMIQKNADKEYHGRVIAYTDMIYLSFSAIISMLMGFLFEIGLSLELITGLLGMIFIFAAFYWKWFYKKYL55 90 26 255 64 490 Core transport protein transcription termination Cj0460 nus A K MEKIADIIESIANEKNLNLENVREKVATALINTAKRIYGQEYEFFVDPKNLNLYQKITIVADNDERLQNKSESFIALSKAKSEAPDVEIGDELTYECSLENLGRTAVNTLHKELEYHIQKLLEQTIFEKYKNKVGQMVFGTVVRVDNEENTFIEIDELRAFLPRKNRIKGEKFKIGDVVKAVIRRVYTDKGIKIELSRTSPKFLECLLEAEVPEIKDGYVNIIGCARIPGERAKIILQANGANIDPVGATVGVKGVRINAVSKELHNENIDCIEFTNESEILISRALAPAIVNSVKIEDKKAIVSLNSEQKSKAIGKNGINIRLASMLSGYEIELNELSSSQLNNAISNEEAMKNLQDLFKI55 90 26 255 64 490 Core factor Cj0459c - hypothetical protein - MELKLARTLINEKPKNISLEKIEEAIKKEGQKFFYFDKDNTHKQLIALVNHFEKKGVSIYHRTVKYGLDDNDFMYEVHIL55 90 26 255 64 490 Core

putative tRNA 2- Cj0458c mia B J MSAKKLFIQTLGCAMNVRDSEHMIAELTQKENYALTEDIKEADLILINTCSVREKPVHKLFSEVGGFEKVKKEGAKIGVCGCTASHLGNEIFKRAPYVDFVLGARNISKITQAIKTPKFMGVDIDYDESEFAFADFRNSIYKSYINISIGCDKHCTYCIVPHTRGDEISIPFNIIYKEAQKAVEKGAKEIFLLGQNVNNYGKRFRNEHKKMDFSDLLEELSTIEDLERIRFTSPHPLHMDDKFLEVFANNPKVCKSMHMPLQSGSSEILKAMKRGYTKEWYLNRALKLRELCPNVSISTDIIVAFPGESEKDFEETMDVLEKVRFEQIFSFKYSKRPLTKAATMPNQIDEETASRRLSTLQNRHSEILDEIVKKQENKTFKVLFEELRAGNSIAGRTDNNFLVQVEGSEELLGQFKEVKITNAKRMVLYGEIV55 90 25 255 64 489 Core methylthioadenosine synthase

Cj0456c - hypothetical protein - MLFLLKKIFPQLFISIILEDKKNIVKASIYRGNKLISSNEKTFDKSENLLEYIKNLSKHFLFYHTALFLDAKEQGLIPSTNIQDCEHFNIGKISLQHILFNNALVYTATEHVEYYSELFEEYRGLDFLYSPFALLYYNIQKEKQPDDQILLYGFKQGHLLAIIVAKGNTILYGDFKIFEQELGLELELPSEDNQEIENNNDDTEVTLDNFNEALNNKFDLLDQENNLETLNNNDNFNLDELNQFSNDMELCRYIITSIEKFYNDDKYAGVFINGILLYSESDINISAIDFLESETFLEIKTKQINTLDLMIELMRKELK55 90 26 255 64 490 Core Cj0455c pil N hypothetical protein NU MTYSFIQPRKKPIFTLFDKIWLGLFGFSISFILLVYFTYTIKIALINSSINDEKQQVIVLQNQTKQNEMLYEILFDQSQIAKNFNTQNQIVKESLRNLFDIIVKTDNITLESVEQDEYSLKLIGVTPTREMFTLLLETPLKSIFDQSYTTYYRLDNGWYRFVSISKQIPGVADER55 90 26 255 64 490 Core Cj0454c - putative membrane protein - MKDKSLEEIDLLKLIICALSFISVCTALILFLLLPTLKNYKQANLRENSQLAILKAAKLKFDFSEDKISTLRSENNKSLEQFEQNFNIGNFDIFLQKYFQNVKIQETKPEKQEKYLKNRLAIKATMNNPRRLYDFIDALKNYNNLIKLDYPLNLKAGEQGISIDLTLKVYSS55 90 26 255 64 490 Core thiamin biosynthesis protein Cj0453 thi C H MKTQMNYAKEGIFTKEMQIVAQKENLSKDFLLENIACGKIIIPANINHKSLDPNGIGFGLRTKVNVNLGVSNDCVDYSEEMKKVELAHKFGIEAIMDLSNYGKTSRFRDELVNVSKAMIGTVPVYDAVGFLEKDLKQINAKDFLDVVYHHAKSGVDFMTIHAGINSRAAHIFKQSKRLTNIVSRGGSVLYAWMMMKDAENPFFEYYDDLLDICLKYDVTLSLGDALRPGSTHDASDGAQISELIELSLLTQRAWDVGIQVMIEGPGHMAINEIEANMQLEKRLCKGAPFYVLGPLVIDIGAGYDHISGAIGGAVAAASGADMLCYVTPAEHLRLPNLEDVREGIVATKIAAHAGDIAKLPKERARDDEMSKARQEIDWEKMFKLAIDGEKAKKMFNERRPDDLNSCSMCGKMCAMNTMNQILKGEDVSLA3 0 0 3 0 6 Accessory ThiC

Seite 4 Table S3 (Cattle)

Ribulose-phosphate 3- Cj0451 rpe G MYVAPSLLSANFLKLEEEVKAIEAAGADLLHIDVMDGHFVPNLTFGPCVIEKISTISKLPLDVHLMVKDVSKFVDLFISLKPKFISFHMESEVHPIRLCEYIRSQGIHPAIVLNPHTPIDSIKHMLEFVDMVLLMSVNPGFGGQKFLPLIHEKIKELRQMIDKKNAKVFIEVDGGVNGLNASDLEESGADILVAGSYIFSSNDYKTAISSLKLEF55 90 26 255 64 490 Core epimerase Cj0450c rpm B 50S ribosomal protein L28 J MARVCQITGKGPMVGNNVSHANNKTKRRFLPNLRTVRVTLEDGTTRKMRIAASTLRTLKKQNSK55 90 26 255 64 490 Core Cj0449c ydc H hypothetical protein S MLHEYRELMSELKGKDAHFDKLFDRHNELDDMIKDAEEGRTSLSSMEISTLKKEKLHVKDELSQYLANYKK55 90 26 255 64 490 Core putative MCP-type signal Cj0448c - NT MFGSKINHSDLQKLEEENKNLTHKIEKFQSENLELKNKITSLEQAALESKLKTDLLNVLLTGVLKNITIIQGDMLENVNKAEVISSYSKTSLAEMDELNHIANSINASLGNITESANKTRDVAETLHRSVDEITNVINLIKDVSDQTNLLALNAAIEAARAGEHGRGFAVVADEVRKLAEKTQKATTEVEMNINLLKQNANEMYTQSEQVEKISIDSNAHIMSFSEKFTHLVNEAHSTNSNAVGIASEAFVSLAKLDHIAFKLNGYKEIFSKSGKQLADHTSCRLGKWLASTGKERFGQNKSFLKINEPHEKVHENMNNAITIANTEDISKDITQHSIINKCEVAENASLDLFNVFKEMLDESDH21 24 26 81 58 210 Accessory transduction protein Cj0444 cirA _3 TonB-dependent receptor P MVALYGENEYFITDDLIFTTGLRYIYSNLFDSEFTPRIYLVYHLNDNIAFKGGVSKGYKTPSAKQLTNGYYNYANGNALFGNPDLKPEESINYELGADFRVFDFAHYSITGFITDFTNQISSEYLTGMQNGINCSNGTVCKRPINLGKTQTKGIEFAFNTKTYNGFSLNSSYTFMDNRYKDSQKNWFGGDRIENLPRHIAMLKLNYERGKFNSYIKTRARLDTIAKAKGGGNGSLPWQKYKPFYIVDLGINYKINKQSSLSFAVQNLFDKNFFNPQVTRWDGANPAGYANRYQDYTEGRSFWLSYKYDF35 66 0 174 6 281 Accessory Cj0444 cirA _3 Ferric receptor CfrA P MIEDTLSISARLKYYDKAASDLKWPTPVWNNNNQKPDNYQQRPDNYQIAIHSPGAFTSLGFGSRLNWTVDDKNNIYFDIERYINEISVNSISSRAIKSEKQLFKDNIVLNHDGNYDFDSTNSYLQYGSTKDKELHSQIWVGEGKVVLPWNLGQYGNLVNTFGARIDYEILKNDQASAGS35 53 0 140 0 228 Accessory succinate dehydrogenase Cj0437 frd A C MGEFSRRDFIKTACISVGALAASSSGVYALDDSSKMDKDINLPSCDVLVIGSGGAGLCAAAAVRKENPKLSVVVATKMMPSRNATCMAEGGINGITDFSNGDSYKLHAYDTIKGGAYLVDQDAALKFCELAGKAIFNMDFIGTLFSRNEQGGVAQRLMGGASKKRCNYSADKTGHILMHSCLDDAISSGVKFLMDHELLDIGVVDGKCEGVVLRDIQSGGIYPVLCKALVIATGGYTRIFYNRTSTPFIATGDGVAAALRAGLGFEDPEMIQFHPTGVANGGTLITEAARGEGGYLLNNRGERFMKNYHEKIELAPRDVVARAIETEIREGRGYGEGLGAYVLCDVRHLGKEKILKDLPKIRHTAMLFENIDLVDTPVPIRPTAHYSMGGIEVAKFEDMSTKIAGIYVGGEASCISIHGANRLGGNSLADAVVTGHLAGIGATNYAKDASFGKGAKTHELAQKWQVRFKEITNNGGNGQEMYELREELGSQNWDNMGIFRTQEKLDLLAKKLEDIQARYEKIRIPNPNEVMNTAFTDYVELGNLILLSRCACLAARNRLESRGAHTREDYPKRDDKNFLKHSIVNLENDELKLSYKDVVVTEFSLDGRRVQ55 78 26 249 62 470 Accessory flavoprotein subunit 3-oxoacyl-[acyl-carrier Cj0435 - IQ MKFSGKNVLITGASKGIGASIAKTLAGFGLKVWINYRSKPELADALKDEIIASGGVAAVIKFDASKEDEFENGVKTIVESDGELSYLVNNAGVTNDKLALRMKLEDFSGVVDTNLSSAFLGCREALKTMSKKRFGAVVNIASIVGEMGNAGQVNYSASKGGMIAMTKSFAKEGAGRNLRFNCVTPGFIKSDMTEVLSNEIKQTYQDNIPLKRFAEPEEVANCVAFLLSDYASYVTGDVLKINGGLYM55 90 26 255 64 490 Core protein] reductase 2,3-bisphosphoglycerate- Cj0434 gpm I independent G MKQKCVLIITDGIGYNKNSKFNAFETAKKPSYEKLFKEVPNSLLKTSGLAVGLPEGQMGNSEVGHMCIGSGRIIYQNLVRINKAIENKELEKNENLQKLLAKCKRVHIIGLYSDGGVHSMDTHFKAMLEICAKNGNEVFAHAITDGRDVSPKSGLNFIKDLKEFCENLGVHFATLCGRFYAMDRDKRWDRVKEYYECLLGKAYKVPNLLEYLQKSYDENVTDEFIKAAQNENYKGMREEDGIIFINFRNDRMKQLVEVLNSKDFKEFEREKIFENLLTMSVYDDKFKLPVLFEKEKIENTLAQVISKAGLSQLHTTETEKYAHVTFFFNGGKEELLENETRVLIPSPKVKTYDEKPQMSAFEVCDAVKKGIEKGEDFIVVNFANGDMVGHTGDFNAAIKAVEAVDTCLGEIIECAKKHDYAFIITSDHGNCEAMQDEKGNLLTNHTTFDVFVFVQAKGVSKIKDNMGLSNIAASVLKILDLEIPKEMNEALF55 90 26 255 64 490 Core phosphoglycerate mutase UDP-N- Cj0432c mur D acetylmuramoylalanine--D- M MKISLFGYGKTTRAIAENLVDKFGPFDIYDDHFTETKKDTLGNLLLNPNDFDDNLSNIEIPSPGFPPKHKLIQEAKNLQSEYDFFYDVMPKSVWISGTNGKTTTTQMATHLLSHIGAVMGGNVGTPLAELNPYEKLWILETSSFTLHYTHKAKPEIYALLPISPDHLSWHGSFDNYVQDKLSVLKRMNECDVTILPKIYANTPTKAHKISYEDEKDLAVKFGIDTEKISFKSPFLLDAIMALAIEKILLDTLSYEPLNSFVMEKNKLEEIKDSQNRLWVNDTKATNESAVMAALSRYKDKKIHLIIGGDDKGVDLSNLFDFMKGFDIELYAIGISTEKMLDYAKKANLKAYKCEVLSKAVNEISNHLRVNEVALLSPACASLDQFNSYAERGKVFKECVNKI55 90 26 255 64 490 Core glutamate ligase NCTC13261_01757 rpl V ribosomal protein L22 J MSKALIKFIRLSPTKARLIAREVQGMNAELAMASLKFMPNKGAKYIANAISSAVANGGFEANEVVVKSCRVDAAAVLKRFRPRARGSASRIRKPTSHILVEVAKAEVKAEEKKTVAKKAPAKKTTSTKKATAKKES55 90 26 255 64 490 Core Cj1701c rps C 30S ribosomal protein S3 J MGQKVNPIGLRLGINRNWESRWFPTKANLVENIGEDYKIRAFLKRKLYYAGISQILVERTAKKLRVTVVAARPGIIIGKKGSDVDNLRKELQDLIGKDVNINIKEERKAGASAQLAAESVATQLEKRIAFRRAMKKVIQGAQKAGAKGIKVSVSGRLGGAEMARTEWYLEGRVPLHTLRAKIDYGFAEARTTYGNIGVKVWIFKGEVLHKGMQPEKTEESAPAKKPRRTRRGK55 90 26 255 64 490 Core

Cj1688c sec Y preprotein translocase subunit U MNRALTNKILITLAFLFAYRVLAYVPVPGVNADVIAEFFNNNQNNALGLFNVFSGGAAERFSIISLGIMPYITASIIMELLAVTFPNIGKMKKERDSMQKYMQIIRYATIVITLVQSIGVAIGLQSLHGRGGAGAIMVEDLNMFIALCAISMLAGTMLLMWLGEQITQRGIGNGISLIIFAGIVSGIPRAISGTVGQINSGEMNFLTAFAIFALILITIGVIIYIELGERRIPISYSRKVVMQNQNKRIMNYIPIKLNLSGVIPPIFASAILMFPTTILQTSTNPYLQAINDFLNPNGYLFHVLTFLFVIFFAYFYASIVFNAKDIAENLKKQGGFIPGIRPGEGTSSYLNEVASRLTLSGSIYLGLVATLPWVLVKFMGVPFHFGGTSVLIVVQVALDTMRKIEAQIYMSKYQTLSAVGL55 90 26 255 64 490 Core

Cj1687 - putative efflux protein EGP MVVWTISGISGFFLNDIYAILTSRAIFGMATAFIMTGASALLGDYYSRGGFNRRENALSLQGFFCAVGGAVFISIAGFVSSYSWRYPFLVYGLGILITLMAIIYLFEPRKFKFYNHTKIETKTNYWQFFPIYFIGFFIMVVYYISPTQLPYYIEEHLGLDPKYIGISMSVSALCYGFFSLSYRYTIKFLSIKTIYVLTLFIVSCSFLLLFLVDSFFTVLIALALLGMGGGIMLVNNTAYLFSICPENARSRAYGILASCIFLGQFLSPIISQPIVRQMGLVDAFLIWSIVIFIVCIVFLFLKQKPRIN37 77 4 196 50 364 Accessory Major Facilitator Superfamily Cj1687 - EGP MNGKTYKFHPNDTKMDKKIIQITEKSGFKAAVFSMAAMTMLGSVVISSALPAINRHFEELLTQSGVLLLQVSH54 14 25 82 19 194 Accessory protein Cj1686c top A DNA topoisomerase I L MKKNLIIVESPAKAKTIGNFLGKDYEVIASKGHIRDLPKSSFGIKIEDDEFIPEYRITSDHSALVKELKSKAKDAKEVYLATDEDREGEAIAYHIAKAIGKDENTLPRIVFHEITKSAIENALKNPRKLNMHSVNAQQTRRLLDRIVGYKLSPLLGQKIQRGLSAGRVQSAALKIIVDREKEIRAFVPLEYFSIDMIFQKDLDAELVEFDKAKIEKLTITNKDRAKLILEACKNEVYSISDIESKERKIAPPPPFMTSTLQQSASNRLGFNPKKTMMIAQKLYEGVNTHEGVMGVITYMRTDSLNLAKEAVENARKFIQANFGKDYLPSKANVYTTKTKGAQEAHEAIRPTNLSFTPEIAAKFLDKDELKLYTLIYNRFLACQMSPAISQTQNVFVKNDRAVFKISGRKILFDGYYKVYGDMDKDKILPNFKIGQNLKVQNLEMNSHFTEPPSRYSEAGLVKKLESLGIGRPSTYAPTISILTSRDYVTIDKKQLIPSDVAFNVTEVLEKNFSDIVDSKFTSNLENTLDEIAEDKADWQETLKEFYYPFMRKIEEGKTKIASQKTVTKLGESCPDCGGELAIRKGRFGEFVACLNFPKCKYSRNLKSESKNESENTAAKAKANGTGITCPSCQKGDIVERFSKRGKFYGCSAYPKCNFISKYKPSEEKCEECGETLVIKELKKGTFLECLKCKIKKEMKD55 90 26 255 64 490 Core Cj1685c bio B putative biotin synthase H MQIMLCAISNIASGNCSEDCKYCTQSAHVKTDIQKYRRKELSQIVLEAKMAKKNEALGFCLVTAGLGLDDEKLEYVCEAAKAVQKEVPNLLLIACNGMASVEQLKELKKAGIFSYNHNLESSKEFFPQICTTHTWESRFQTNLNAKEAGLMLCCGGIYGMGESEEDRLSFRKSLQELQPFSTPINFFIANENLKLQVPRLNADEALKIVRDTKEALPQSVVMVAGGREVVLRERQYEIFQAGAGAIVIGDYLTTKGEEPSQDIIKLKEMGFTFASECH55 90 26 255 64 490 Core Cj1681c cys Q CysQ protein P MLNLDKFLEIAINASNQASKAILEERKNFKTWEKEDKSPLTSADLASNKILNDILGSTDIKILSEENLLSKEECEELKTFWLIDPLDGTSGFLKGSDEFCVMISLVHDNRPVLSLIQNPSKGDIFYAHAKTKVYKNDKPLQIDQQEYEKNKYKALLSVNHLSKEDEDFAKEHQLEAINIGSGLKFCAILEARAGVYKRFEKLNIWDIVAGDFLINQNGGFMGDFSKKYILYNPLSYKSNPFICVSSRNFLQDFL55 90 26 255 64 490 Core Cj1673c rec A recA protein L MDDNKRKSLDAALKSLDKTFGKGTILRLGDKEVEQIDSIGTGSVGLDLALGIGGVPKGRIIEIYGPESSGKTTLTLHIIAECQKAGGVCAFIDAEHALDVKYAKNLGVNTDDLYVSQPDFGEQALEIVETIARSGAVDLIVVDSVAALTPKAEIEGDMGDQHVGLQARLMSQALRKLTGIVHKMNTTVIFINQIRMKIGAMGYGTPETTTGGNALKFYASVRLDVRKVATLKQNEEPIGNRVKVKVVKNKVAPPFRQAEFDVMFGEGLSREGELIDYGVKLDIVDKSGAWFSYKDKKLGQGRENSKAFLKENPEIADEITKAIQNSMGIEGMISGSEDDEGEE55 90 26 255 64 490 Core Cj1672c eno enolase G MLVIEDVRAYEVLDSRGNPTVKAEVTLSDGSVGAAIVPSGASTGSKEALELRDNDERFGGKGVLKAVANVNETIADEILGLDAFNQTQLDDTLRELDGTNNYSNLGANATLGASMATARAAATALGMPLYRYLGGANASILPVPMCNIINGGAHANNNVDFQEFMIMPFGFTSFKEALRSVCEIYAILKKELANSGHSTALGDEGGFAPNLANNTEPIDLLMTCIKKAGYENRVKIALDVASTEFFKDGKYHMEGKAFSSEALIERYVELCAKYPICSIEDGLAENDFEGWIKLTEKLGNKIQLVGDDLFVTNEDILREGIIKKMANAVLIKPNQIGTITQTMRTVRLAQRNNYKCVMSHRSGESEDAFIADFAVALNTGQIKTGALARGERTAKYNRLLEIEFESDEYLGEKL55 90 26 255 64 490 Core Cj1670c cgp A putative periplasmic protein S MKTRILAIFFIFTSLLYADENPFKTDQNITLVAPPEFQKEEVKFNSSARILKSITFNYINLDGSEDKIDLDVNKSIDWHDTYTISRFKSPDPSKVLDVSVTIPEKNSSKQESNSTANIEIPLQVAKIYDFISYAVYKNKIKLNTSDEMITDFSVGNPSKIVIDFRSKMISPTKNIRLSNSIFKRIDFGSHKGYYRLVIYLDGTYNYNIQKDATGYMINLL55 90 26 255 64 490 Core putative ATP-dependent DNA Cj1669c lig L MRFVFLICCACLVFANEILLLSKFDKQDFNSKDFNAYLMSEKLDGVRGIWDGKYLKTRQNYKIKTPDFFTKNFPPFAIDGELWIARNKFDEISALIRSGDSNLTLWKEVTYNIFDVPNACEEFQISTCALKNRLAVLEEYLQKYPSAYIKIIPQIPVENQNNLNQFYESIIKNQGEGIVIRKNLSPYEKGRSKNAMKLKPYDDAECELVGFRKGKGKFENQVGALLCKMPNGQIIKIGSGLKDEDRKNPPKIGSIVTYKFNGLTKNSLPRFPVFLRLRDENP55 90 26 255 64 490 Core ligase NCTC13261_01720 - integrase L MLIHSGRRRDEVLSLLWQNVDLERKTIFLPKTKNGEAQEHALDDECYNALKALKDEVKQDKGLVFVSSVSGKKISNLARQEAKIRELSGVKEWTPHFSRHIKASFLMQNGVNPAVISGALGHRDLSTINIYATNDTLKASQRANEALKKLQEKD35 20 0 1 4 60 Accessory NCTC13261_01719 Hic A HicA - MLGLEFIFSKQRLEHYKDINEHFENLKLISKIMPKIAILEIYLRNALDYELNSNCKEWIKTSDNPFLLAKINEFKDKDSLKPHQILSRLSLGVVAKLIISYKVQNKILDLRAFDFRKYSSSNRNFFIYENTKQGFDNIDKVNIVLNLLHTLRNRACHFENLLKIRENDNKLYPRISTKEKGTNIGLMPDKIENFLNDLICLINKDLLDYLNRG35 20 0 0 4 59 Accessory NCTC13261_01718 - hypothetical protein N MHLKYFKIIIYNTYMNNKEKLIKELENNPKNASFANIEKLLSWYGYKLVSVKGSHHEFKKDNKSIIVPLHKPIKEFYVKQILKLLKDEK35 20 0 0 4 59 Accessory NCTC13261_01717 Hic B HicB S MKKDINYYLNLPYKINLLKLDDGDYFAQFDDKELNKLVLMAGDGKTPNEAIEDLKNAFACYLEEALAKNEFIPEPMQKDKSKNLAITLKNSLIDEIDFYSKKMGLSRSAFLAVSAKAYIKTL34 14 0 1 4 53 Accessory NCTC13261_01716 - putative protein - MNLILENPSEKLIKAVKAMAKIENTKVKLKKRKETYY35 0 0 0 0 35 Accessory putative RelE/StbE family NCTC13261_01715 yaf Q - MIKYTLKKSKEFKEGVKKLNKVEKVKKYIIF35 0 0 0 0 35 Accessory addiction module toxin helix-turn-helix domain- NCTC13261_01714 - - MQDTNKDFLTIQEVITLYSLSKDTQNKYRMQKKIPYIKIGKKIFYEKVKLDEWFKNHTIN35 19 0 1 4 59 Accessory containing protein NCTC13261_01713 - hypothetical protein - MNDRQALEYLKDELLFIFNVRFKYFDFSMFSLLKDKLRPLLKNASFEKEIKELLSVLEVHKKSFLENKVFIKKEQKRIILLNACKATYEALKHKLKA35 0 0 1 0 36 Accessory NCTC13261_01712 - hypothetical protein - MSISLFNDEIKAYIKNYYSIVDFLYLRYGLEFDRQGNEKHNKSLKIKTNTCLITDFNGSFSGDIIDFIAFKEDVELKEALIIFSDFNRLPTHKEYNFKLQKEPLKDNSYLKNIAYSLQANFNLANSDFIECKALEKAFFNDFRLFMHLCKLNFLKDDEFESILKDYFAFSKDDKSLAFVLKDKNEIKSVAIREKLFKNELVKWFKVKGSSNKFIKLIKAKEKGLLKDYCFIFSGIKEIIVSELLGLNAVCFQSDSMMKNIHSHEQINELLNLIDNKRIVFIVENDESSFKANLELLKELVQIKPLKKGYCVFNYDEVKNADFIDFLAYLMKELRQDYQRDKKGLNSFFSYMEKYFKNYFNKKINLFLKATK34 7 0 1 4 46 Accessory

Seite 5 Table S3 (Cattle)

DnaB-like protein helicase-like NCTC13261_01711 dna G L MKDYSKEINDLKKIKSQAIDKLDFKEFENIESQINETSYNSSKIIPQNTNIKNNSFVDLTQWAIRSVDLEKIEFTSLIDDFLDKGSISFLTSEANKGKTFLSFAICKHLLEFNKIRKIIYFDGDNSKITIKSRIKKSMQIGGYYFLDYPAFNYIQTSNALECGTDEIEVDFNFIVEKYLEPLMQSGGLVDVFIVFDSLFNFFNGDMNDNKKVAEFMKIIKKISHKGEATFLFIHHKGKSAESEFMGGVNFLNATDNLFKIQTSNNDGEILNIELNTKKARNFLPYNLKVDIDLNTLDLKIERAINENDTNFLAKAKEIIEQKGEILQGELLELLEKSKTDTHAIKKLESGKGLYFNIIEKSRATGGKALKYYVPLKENKTIINGIEINAEQTLFSE30 19 0 0 4 53 Accessory protein NCTC13261_01710 - hypothetical protein - MTRLEFDEKIKQLGLTRKTFADIAKVSYSGISTNWKDDKEIPSWVEPFLYYYEKGLALDELLKILEKYKKESNLE35 0 0 0 0 35 Accessory NCTC13261_01709 - acyl carrier protein K MTKEKFNQLLKQANLNKKQLADISGIPYPTINAWGSTTSYPPYITFLLENYIKAQSYEELKNKVFEIENIK34 0 0 0 0 34 Accessory NCTC13261_01708 - hypothetical protein - MEKVDYCRMSCLDGQINGFKYFLDLFLSDLENENDVKTCNMFDNDTSIEYVKDMLMMMLDKIKEIVIDQDNHYYNANNHVSTYRCLVKDELGKEFSIKELEELHKEQEERLLRQLYEESKKK35 0 0 0 0 35 Accessory NCTC13261_01707 - hypothetical protein - MQTITIKAKEQEINKLLDILKEMNISYELESNNYENALAEYESGKSWQETKQELHKALNDYESGRAKLTPLGSEWL35 0 0 0 0 35 Accessory RelE/ParE family plasmid NCTC13261_01706 - S MQILESDLFTNELNIILSFIVRKESIKAKNTFKNDLYKALKKLDFMPYKFRKSLAFDDENVRDFIFKGYVIPYKIDKEKDLIIILGIYKENLPNF35 20 0 0 4 59 Accessory stabilization system protein NCTC13261_01705 - putative periplasmic protein - MKKLGLALAVLVALNVSAFADLIVINKKDLVPVSASEMQNKYFQESIKTIIDELLFKKATFYEADIVAKVDPKTYKVNQSMIKDYYSDKSKYVYYKTVLILTSDGKRARLSTLTCDVSSFDKKGYFCGGTAEHNYSIK35 38 0 193 43 309 Accessory putative integral membrane Cj0313 CP_0860 S MWIFFRFISGIYLKNFFIIFFSLLGFYCGIDLLLNFKDLPKAANLDLLYVMFLSFSAAPYVLPISLIFALVVSLISMIRANEFVSLYALGLSRNYVILFPFLWALFFCCIYIGLNFTSFAYANDYKRNILKNGTIMNQSGEVFLKFNNNFVYISKINNGQNSAQNIKIFNINDLNLSSFVSAKNAHFEGESWILRDGNITLLPKNYELANDGLKIQDFSELKSLEGFKPKIIEGVASNSDYSISDALESFELFKAQNVNTDTLKINLYKFVFTPFFAPFLMLIMYYFFPVIARFFNLAFVTFIAFVVTLMIWGVLFLLTRLSENSVIASEIGIVVPIIILGCLSAYMYYKHR55 90 26 255 64 490 Core protein diaminopimelate Cj0314 lys A E MDYKQLKQEFNTPFYIYNFDFIKERFLNLKEAFKARKSQIFYAVKANSNLSLLQMLANLDSGFDCVSIGEVKRALKAGAKAYKIIFSGVGKTKEELRQALEYDILYINLESEAEMMLLESVAKELNLKARISIRVNPNVDAKTHPYISTGLNENKFGVEIDIARKMYLYAKNSSFLEPVGVHFHIGSQLLDISPIHEAAAIVAKLVRELKALQIDLKFFDIGGGLGVAYEKNECEPDLYDYAQGILAQLHGLDLTIGMEPGRYLVAKSGEFVCSVLYEKQNKTKRFVVVDGAMNDLIRPSLYEAYHEIILPYNQAQESLCDVVGGICESGDFFAKARSLPSTQSDDIMVIKNTGAYGFSMSSNYNTRNKVCELALEEGQVRLIRQRENFEDQIALEEKFLKA55 90 26 255 64 490 Core decarboxylase chorismate Cj0316 phe A mutase/prephenate E MPNLEEFRNKIDAVDDKILELLNERMTYVKSIGELKQSSGGAIYRPERERAIINRLKNANLGLLDQNAIEAIYQEIFAVSRNLEMPQTIAYLGPEGTYTHQAARSRFGAMSRYIALANIEDVFKELSNKEAKYGVVPIENNTEGAVGITLDCLGKYNELKIFGEIYMDIHHSFVGINENLKEIKRIYSHPQGYNQCRKFLESHELSAIEFVPSKSTANAAYLASQDKYAAAICSKIAAKLYNVPVLFDKIEDNAANKTRFLILSDIKNPKMPNCKTSILAHTAHKPGGLSFLLEQFKKEDINLTKLESRPVKSKEFLHSFYIDFEGHIDDENVKKALKDIQEIVWLGSYLSGEKDEI55 90 26 255 64 490 Core dehydratase histidinol-phosphate Cj0317 his C E MKFNEFLNHLSNYEPGKDIEVIAKEYGVKEVIKLASNENPFGTPPKAIECLRQNANKAHLYPDDSMIELKSTLAQKYKVQNENIIIGAGSDQVIEFAIHAKLNSKNAFLQAGVTFAMYEIYAKQCGAKCYKTQSITHDLNEFKKLYEAHKDEIKLIFLCLPNNPLGECLDASEVTKFIKGVDEDCLVVIDAAYNEFASFKDSKKHLEPCELIKEFDNVLYLGTFSKLYGLGGLRIGYGIANANIINAFYKLRAPFNVSNLALKAAVAAIDDDEFTKKTLENNFSQMELYKEFAKKYDIKIIDSYTNFITYFFDEKNSTDLSEKLLKKGIIIRNLKSYGLNAIRITIGTSYENEKFFTEFDKILR55 90 26 255 64 490 Core aminotransferase Cj0318 fli F flagellar M-ring protein N MDFKNMLHQIGQLYQNLTRKQRIVIAASIIVVVGFLVFLALFRGSGSNANNGYAVLVENVSPSSSAAIVAKLEQNNIPYKLESENKILVPQDQVYRQRMFIASEGLIKDSRVGFEAFDTQAFGATNEEQKVKYQRAIEGELARTIETLEPIRSAVVHIAFPKDSVFTERQIPPTASVVVNVREGLKLTRKQIDGIKNIVSAAVPKLTKENVKISDQSGVPLDEQEAYEDDLVRAQIKFKSDQEKALEDKIIENLAPFAGGMDKVKVSVNIDFDFSKQESQSEIYDPNPIVRSEQTLNEERTGRKDPEIQGVPGAVSNIGPVEGLDNKGQIDTYKKNQVTTNNELSKTITNTKKQFATVLRTSAAVTIDGKYQDVVDENGDVKSEYVPLTKEELASVESIVKNTINFSATRGDSVVVQNLPFHRESIRVESKVKTFYNRFVEPFIPPVKYFIAAILLFIFYKKVIAPFTQKMLEDVAAQEEMQQGPNAVLDDAEDALEKFNAARKKVEEQLGFGDNFNEDSIQYEVLLEKLRGLVSDKGEEIAALLQNLIQNDSEFGEKDM55 90 26 255 64 490 Core Cj0360 glm M phosphoglucosamine mutase G MKLFGTDGVRGKAGEFLDSFLAMRLAMAAGIYFKDKSITNNILVGKDTRRSGYMIENAIVSGLTSIGYNVIQIGPMPTPAIAFLTEDMRCDAGIMISASHNPYYDNGIKFFDAHGNKLSEDIEKKIEEIYFDDKLIQASKVDMEKIGQAKRIDDVIGRYIVSIKNSFPKDLTLKSLRVVLDVAHGAAYKVAPTVFKELGAEVIVMSDKPNGLNINENCGALHPANLAAEVKRLRADVGFAFDGDADRLVVVDEKGEVANGDSLLGVLALYLKEQGKLQSSVVATIMSNGALKEFLNKHGIELDTCNVGDKYVLEKLKANGGNFGGEQSGHIIFSDYAKTGDGLIAALQFSALMLSKKKSASSILGQVKPYPQLLTNLKIAEKKDLDKIKGLKELKKDLENKNINTLFRYSGTENLIRLLLEARDIKLLEKEMKNVVEFFKKALNG55 90 26 255 64 490 Core Cj0392c pyk pyruvate kinase I G MLKKTKIVATVGPASEKEEILRQMIINGVNVFRLNFSHGTHEYHKKNLDTIRKVAKELHTRIGILQDISGPKIRTGELKEPFELKKGDRLDFYRETILGEKIAQNHYKISINQKSILDMLKIDEYIYLYDGSIRAKVVSIDDQKIETIIENDGFLNSNKGINFPNTKINIDVITQKDKNDLLWGIKNEVDFLAISFVQNAHDIDEVREILAQNNAKISIFAKIEKFDAVENIDEIIKSSDGIMVARGDLGIEVPYYKVPNIQKEIIQKANNASKPVITATQMLFSLAKSKTATRAEISDVANAVLDGTDAVMLSEESAVGIDPANAVDIMCQTIIETEKRYPYNKFNDFNDLDNTDKIMRSSAHLATDLNADAIFSLTSSGKSAIKIARYRPNIEIIAVGHSEKTLNSLSIVWGVNPAILVNKSNELTELLKDSVRSSVEKGFMDEDKCYLLTAGFPTGVEGTSNLIRILNKEQIAYYLQ55 90 25 255 64 489 Core putative malate:quinone Cj0393c mqo C MSQQEFDVLVIGAGISGAALFYELARYTNIKNIALIEKYNTAATLNSKGTSNSQTIHCGDIETNYTLEKARKVKRTADMIVKYGLMQNAQNNFMFSHQKMALAVGDIECDYMKKRYEEFKELYPYIKFFDKAKIKQIEPKVVLGEDCNQDRPENICAMGVESGEVFTTVDFGKMSINLIEQAQKQNKNTFVAFNQEIIHIEKKDDIFILKTSNHQEYHAKSVVVNAGAHSLYLAHKMNLGMDKSCWPVAGSFYLTKQKLLNGKVYMVQNPKLPFAALHGDPDLLANMNTRFGPTALVIPKLERYHGLKSVPEFFEALKLDKTVLKVTFNMFKDATIRNYIFYNYLFELPFIDKSLFVKDAKKIVPSLKASDIYYAKGFGGVRPQVIDKTKEELMLGEASITETPGIIFNMTPSPGATSCLGNAERDAKLVCNYLGMEFNEDKFSSELL55 90 26 255 64 490 Core oxidoreductase putative transcriptional Cj0394c coa X F MLLCDIGNSNANFLDDNKYFTLSIDQFLEFKNEQKIFYINVNEHLKEHLKNQKKFINLEPYFLFDTIYQGLGIDRIAACYTIEDGVVVDAGSAITIDIISNSIHLGGFILPGIANYKKIYSHISPRLKSEFNTQVSLDAFPQKTMDALSYGVFKGIYLLIKDAAQNKKLYFTGGDGQFLANYFDHAIYDKLLIFRGMKKIIKENPNLLY55 90 26 255 64 490 Core activator Cj0396c pgb B putative lipoprotein - MKKIFLTLFCLIFLCACGTKRQYFEPKQTDGDLSHNSNLKSKIVDWNLVSAKLSNNTAILKNNISIDKFKLPKNYMLLAYQDGEYFTADNNGNLKIFDNSYNEIYNFQFDASVVGVASNGDDLALVLANNTIVLANRSLGIKFSQTLTSAPAQDSRTANPIFLDNIIVYPTLDGKILILSRNNLQVIKDVVISAENFFNNVIHLSVIGDKLIAATAKKIIVVSPARTLYLDADIKDVALSDDGIFILEKDGTIIKTDYNLRKIAEKKFEFAIFVKSNIYNNYLYIFEKTGYLIKMNLNLDNTQVFKLSEAVDKISFMGNGKFYYGDKILDLL55 90 26 255 63 489 Core Cj0397c - hypothetical protein - MGLKDNLKAVKNELNTEERFIENFIKGERFIRKYKFYISAVVIILVAWFAGNFIISKINDYKTKEANEIYANLIQDPSNKNLLEQLKNKNTNLYTIFLLKENINDLNNTAFQNELKQIYNNAQTNTLLKNIIALSLGDKSIFLKNYDKLLEAYKLLEQNKIEEANVLLSRIKENSSLNQIAKNLKHYQGITQ55 89 26 252 64 486 Core Glu-tRNAGln amidotransferase Cj0398 gat C J MQIDEKLLSKLEKLSALQITKNRNETIAQLSEIVNFVEKLNELDLDSQEITVSTIKGGAPLRIDEIRNSNVIDEVLDCAPKKQEHFFVVPKIIE55 90 26 255 64 490 Core subunit C Cj0399 cvp A cvpA family protein S MNFYWFDAFILGFTLLLGLKGIINGLIKEIFGLLGIIGGVFIASKYATQAAEFIQSTFYKIENQSLAGFAGFLAILIIFWIVCLLVGNFLSRLIKLSGLGFLDRIGGFIFGGAKIFLIFAILVFCVARIDFLNDKLDNFAKNSYTLNLLKETGSFIMNQPLTENSLDHASEKLQDIVSDLNNTQKGE55 90 26 255 64 490 Core Cj0401 lys S lysyl-tRNA synthetase J MFDNILEQQRIEKAKELKKLGINPYPHFLEKEMSLKTFKDKFSYILEQVEKRDESVNAVVAGRLKLLRIAGKSIFANIEDEDTKLQIYFSKDSVGEELYTILKKNLEVGDIVLVKGFPFVTKTGEFSLHASEVKLATKAIVPLPEKYHGLTDIEQRYRKRYVDMIMNVEVRKDFLVRSKVVSLIRHFFENKGFLEVETPMMHPIAGGANAKPFVTFHNSLGVERFLRIAPELYLKRLIVGGFEAVFEINRCFRNEGMDLTHNPEFTTIEFYWAYHNYKDLMDLTEELFALLLDKLNLGKTIEFDGKMINFSKPFERITYKDALCKYGGLDRDLIEDKEKILTKLKADGFEANEKLELGHLQAELFDNYVEEKLINPTFVIDFPISISPLSRRSDEDSQIAERFELFICGRELANGFNELNDPLDQYERFLKQIEAKNAGDEEACEMDEDFVNALGYGMPPTAGQGIGIDRLVMLLTNKKSIRDVILFPAMRPLKSELKEKE55 90 26 255 64 490 Core putative transmembrane Cj0404 - S MENQKNEFDDIILEKSNKSEKVKKILLRVIALVILFLAIMIVMKLINGSGDENTQNQSVLPSEPIATQDNNNDTSFESMPITDNTSAEDQFEALRKQFQDEQNTTQNTTTSSSNNNDTTNFAMPDQEVPAEPTATASENTTPQASTPKQEVTQTAKPKEEAKKQTAVKKEKESAKQTPKKEQNANDLFKNVDAKPVHPSGLASGIYVQIFSVSNLDQKSKELASVKQKGYDYKLYKTTVGGKEITKVLIGPFEKADIAAELAKIRKDIAKDAFSFTLK55 90 26 255 64 490 Core protein Cj0405 aro E shikimate 5-dehydrogenase E MKFLAVIGDPISHSKSPRMHNNAIKALGLDSIYTRYHLRNANCLREDFFKLGLSGANITLPFKEKALDIADVKDDFARNIGSANTLCLKEDKIYAYNTDALGFLEAIKDFDNIKKALILGAGGTALALAYVLKQKGVEVYIANRSKERFKDFLAYPTYLYKNLQDFDFDLVINSTSAGLKDENLPCDRELLDRILPKAKFAFEVIYGRETPFYRLCKEYHLKIKDGLDMLLWQGVFAFELFFEIRDKREMIKNAMQQALILK55 90 26 255 64 490 Core Cj0406c - lipoprotein, putative - MKKYILLASSMLILAACGGTSSNFVNVSMPNFKPQVPTKVEPIDSGVSIALEPINIEQNNNYSDYFENSVLKIRIEKEIDLLKRNLEEQIKTIAQLKGYKIVTTNPDYTLKSSISIYTEEKNAQKTSNFMSGDYVKSNLGINFKGKIDFIDAHNPQNSTNLSSSTKLDSLVALNYPIKNDDGVNMFKTTISTVPTQLNKGLEQPAFEIDKSFLAFYKNTLNTLYNNLPKATDIGKTIPNTNSGFNSFDGDATFEESLPQTNSNQNNTIENTPTQNIPTNPSSTNQNNQSKNQDGVEIFE55 90 25 255 59 484 Accessory Cj0418c Cj0418c hypothetical protein M MQISSSYNSYDYYSSKPSFDKTNQSDSNQKDEKNLSENKDDKEKNGEQTQMVNGVELSQKEVAQVRELQSIDRNVKAHEAAHQAAGGGLAGAASFTYTRGPDNQMYATAGEVPISMQKGNTPEETIANARQIAAAAMAPADPSPQDYKVAANAAKMEFEARAEAMKLKAEEAKEKEEENKEKDDKNSENSLEKTDKDSKNNDKNSNFDKDFKNFVARTYQQNSQNNDIKFNIAS54 34 26 93 41 248 Accessory Cj0420 Cj0420 putative periplasmic protein S MKKVVLSSLVAVSLLSTGLFAKEYTLDKAHTDVGFKIKHLQISNVKGNFKDYSAVIDFDPASAEFKKLDATIKIASVNTENQTRDNHLQQDDFFKAKKYPDMTFTMKKYEKIDNEKGKMTGTLTIAGVSKDIVLDTEIGGVVKGKDGKEKIGFSLNGKIKRSDFKFAASTSTITLSDDINLNIEVEANEK55 90 26 255 64 490 Core putative integral membrane Cj0421c Cj0421c - MFLLDFLISLSFIFEISALVLSFYFKNSRIFFLTLVLLGAKLPYFYTSFFQANLFVALFLPMVFTLFCLGKHHTLILSKKNIASITTLIFIGILSIILPRNTTFNSAGLEFHFITLNFFKPMSELGFLFFLVGLILIFIKTFKTKEYYLIIAFFTAYFQFLFQEGAGIRYFEFASLVFCFYLLNHAYRLAFFDTLTKLPNEKSLTRFTKGKNNYIIALLHFNELKDTKESYAKLILKQIAKILKRFRTKIFIVENDFILIFNDKNQALNHLAFLESTLKNTEFNLENENFKPDFKLIWQESEENLDKNLQSLRAKLLD55 90 26 255 64 490 Core protein putative H-T-H containing Cj0422c - - MTKKSKRDMAYELDIDVSTLYNWRKYKPNLYRIVMLGFKFDELLENSKKTHEELLHIEQTIQDEIAKFK36 85 26 255 49 451 Accessory protein NCTC13261_00426 - integral membrane protein - MDFNSVLFSIGDKLPKDATSTVTLKEKFDRLNEDKQKEVVAQLPMIKLKSPALVFWVGTFLFGAFGVGRFMIGDWVLGLIRLGITIVAMFCGILMITYSALGIIYGLLWLVNWIWWIVDMFLVGKKLRKQNFEKIANIIQ35 0 23 44 14 116 Accessory NCTC13261_00427 - lipoprotein, putative - MKCFNAKFMFIGILAVFLSACSSGIPKCSDQDVQNVLTEIILEHNFGRFSEVDRKKLKFTYSGFMSDLTDKESKTQYCKAQVKANGSIDSRPYKWDA35 0 23 44 15 117 Accessory NCTC13261_00428 - Integral membrane protein - MDYNVFLLNIQDKINQEDFFNLKLKFEQLQNKKEALSNLVFLRLQDPIKPLIMSMICGFLSLGWLAIDRFMIKDYALGILRIILSLFPCVLFLILGISYENDSNLDISEIFFGLFGIFLLLGIIWWGVDLFLVYKKIKKQNYNKIIEFIFNYQKI26 0 23 30 11 90 Accessory

Seite 6 Table S3 (Cattle)

putative ABC transporter ATP- Cj0426 ybi T S MVEVKNLTMRFANQLLFENVNLKLVRGQRYGLIGANGAGKSTFLKILSGEIESSSGEIVFDEGLKIAVLGQDQFAFENYTIKDAVMCANKRLYEALKEKEKLYMSEEFTDEINERLGELEIITAEEDPNYDCETRCEKILSSLKIKDFDALMSTLQSADKFKVLLAQVLFLGADVLFLDEPTNNLDLEAISWLENELLRHEGTLVVISHDRHFLNKICTRILDVDFKQIRDFAGNYDDWYMASTLLAKQAELKRDKTLKEREELENFIRRFSANASKAKQATSRAKALEKLELEEIKISSRRDPSIVFRTNREIGNEVLEFKGIGKAYDKQLFSNLELKIEKNDKIALIGANGVGKSTLAKIIAHAISPDSGSIHLGATIELGYFPQDTSNLICENLKLYEWLMSEKFKDLDEIRKCLGRMLFSGSDQEKMAASLSGGEKHRLMLSRLMLERPNFLLLDEPDNHLDLESIIALGEALYNFKGVVLCISHDRELVSAFANRIWHLENGKLTDFRGTYQEFLGENDG55 90 26 255 64 490 Core binding protein Cj0427 - hypothetical protein - MAKFRIQYSAGFGHYTQNHKGFGPTIYIEEVVEFDNGKDYFDYIDFYKTYSKSDDTYFHISFLEDRPLSDKEITIRNEYRKMRDENCKKAKEEFIANNELDVEHLPTHHD55 90 26 255 64 490 Core Cj0428 - hypothetical protein - MQVNYRTISSYEYDAISGQYKQVDKQVEDYSSSGNSDFMDILNKADEKSSGDALNSSNSFQSNAQNSNSNLSNYAQMSNVYAYRFRQNEGELSMRAQSASVHNDLTQQGANEQSKNNTLLNDLLNAI55 90 26 255 64 490 Core Cj0429c yig Z hypothetical protein S MQTIDQIFQTQIDIKKSIFLSFLCPFKDFKFLIETLKKEHPKAVHFVYAYRVLNDFNQIVEDKSDDGEPKGTSGMPTLNVLRGYDLINAALITVRYFGGIKLGTGGLVRAYSDAANTVINNSSLLSFELKKNITIAIDLKNLNRFEHFLKTYSFNFTKDFKDCKAILHIKLNEKEEQEFEIFCKNFAPFEIEKL55 90 26 255 64 490 Core Cj0430 - putative protein, PMT family M MEKIKNYKLIIILLSLDLLALLYGISTLSISADEADIYFGEQGKSLIFSHSLLYYISHFGTFIFGQNDFGLRLPFLFFHFLSCLLLYLLALKYTKTKIDAFFSLLLFVLLPGTVASALLVNAASLVIFLTLAILCAYEYEKKWLFYILLIIVLFVDKSFNILFLTFFFFGIYKRNAILFTLSLVLFGASIGFYGFDTGGRPRGYFLDTLGIFAACFSPLVFVYFFYTIYRLTFQKYKNLLWFLMSVTFVFCLLLSLRQKLFLDDFLPFCVICTPLLIKTLMQSYRVRLPVFQLRYKIFIECSIIFLIFCYFLIVANQLLYYFINNPNRHFANNYHFAKELALELKKQDVLELATAPSLQKRLRFYGIKNSNKFYLKALKQGDKHDMDKKIVKVKLGKYEKVYQILNYD55 90 26 255 64 490 Core Cj0431 - hypothetical protein NU MIKAFSLLEFVFIILILGIVFNLGSLYLKKDNLLEGAIQILNDIQYTQSLAMMQEGIRVDELAIAKREWFKSKWQIYFIKSAATGYDQTYTIFLDKNGDGNANLGKTEINIDREIAVDVINHNKLMNSGQSGVISKDDEKTTQRFNLTKRFGIEKVEFKGSCSGFTRLVFDEMGRVYSPLKNANYAYEKTLAKNNSDCIIRLLSKKHALCIVIDTLSGYAYIPDFKTLKSQFVSIKNKNYECSKI55 90 26 255 64 490 Core outer membrane protein Cj0129c bam A assembly complex, YaeT M MKKHLISICALVAMANAATIKDIKFIGLNHLSNTSAINIAGLKIGEEINPAKINTAILNLYKQNYFENIAVENNNGILEIIVTEKPTIAKVTITGIASNDRKQVESILGIKRGTLLDEGNIKEAIKRIKAYYEAKSYFDTIVEYKKKTLENTDGLELEFIVNRGENIIIDNVHLSGAKKFSYSDIEPAVVNKEKEFMGWMWGRNDGKLKVFELSNDSSRIADEYMKKGYLDVQVSSPYLKTYTDTYQANLTYFIKEGKPYKIKSISIENPLFDDKQNAQTVKDLRSSAGKTINIEDIRKDVKTIETQSADLGYAFVEVYPDIQKNDQTQEATVVFKVIPHDKVYIRNVIISGNSRTVDRVIRRELYITEGNLYNRTDLSESKNALKRTSYFNDVNIKEEKVDDTHIDLIVDVKEASTGAISGGIGYGSSDGILLNASLSDTNIFGSGIKSSVSVDKSDDTLSGRISLVNPRVLDSQYSLGGTLYSNDYEWDNYSEKNYGFDITIGRQFARYYNISLTYNLEQSDIYHLSPTLLRTGYELGKSIKSSITPAITFNNTDDYYLPRSGIIASTSLEYAGLGGDQEFISSSSKFNFYQGLQDYIGYDLIYRYKASFYKVWDEGYLPINQRIYLGGIRSIRGFESRTVSPKNQWGDEVGGTIAFANSVELSFPLIDRIKLRGSVFFDYGMIGRKNLDEIKRMSTGIGIEWITPIGPLQLVFAKPLNDKKGDDTNSFEFNLGTRF55 90 26 255 64 490 Core protein acetyl-coenzyme A Cj0127c acc D carboxylase carboxyl I MNFADIFSKIRRQQPSIKEAPNHWVKCQSCHALMYYKEIESCFNVCPKCNYHMRISADERIKLLSDEGSFIEHDANLEAIDPLKFVDSKSYKKRLSEGESKTGRKSSVISGECEINGLKTQLVVFDFSFMGGSLGSVEGEKIVRAIQRAITSKTSLVIVSASGGARMQESTYSLMQMSKTSAALKLLSKEKLPYISILTDPTMGGVSASFAWLGDLIIAEPEALVGFAGARVIKQTIGADLPEGFQKAEFLLEHGLIDAIVERGEQKQYLSDVLKFFSGK55 90 26 255 64 490 Core transferase subunit beta ATP synthase F1 sector alpha Cj0105 atp A C MKFKADEISSIIKERIENFDLNLEIEETGKIISVADGVAKVYGLKNIMAGEMVEFDNGDKGMALNLEESSVGIVILGKGEGLKEGTSVKRLKKLLKVPVGEALIGRVVNALGEPIDAKGVINSNEFRFVEEKAKGIMARKSVHEPLHTGIKAIDALVSIGRGQRELIIGDRQTGKTTVAVDTIISQKGQGVVCIYVAIGQKQSTVAQVVKRLEEHGAMDYTIVVNAGASDPAALQYLAPYTGVTMGEFFRDNAKHALIVYDDLSKHAVAYREMSLILRRPPGREAYPGDVFYLHSRLLERASKLNDELGAGSLTALPIIETQAGDVSAYIPTNVISITDGQIFLETDLFNSGIRPAINVGLSVSRVGGAAQIKATKQVSGTLRLDLAQYRELQAFAQFASDLDEASRKQLERGQRMVELLKQPPYSPLSVEKQVVLIFAGTKGFLDDIAVSRIEEFEDGIYPFIEAKHPDIFEQIRSKKALDSDLEEKLAKAINEFKANHL55 90 26 255 64 490 Core subunit Cj0100 par A parA family protein D MSEIITIANQKGGVGKTTTAVNLAASLAVAEKKVLLIDIDPQANATTGLGFNRNNYEYNIYHVFIGRKKLSDIILKTELPQLHLAPSNIGLVGIEQELAKGENNEKKMLLKNQIQEVIDEYDFIIIDSPPALGSITINAFAASDSVIIPIQCEFYALEGVAMVLNTIKIIKKTINSKLRVRGFLPTMYSSQNNLSKDVVDDLKQNFKKQLFTINGNEDDFIVIPRNVKLAESPSFGKPIILYDIKSPGSVAYQNLAYSILG55 90 26 255 64 490 Core putative biotin--[acetyl-CoA- Cj0099 bir A H MEKGLKVKIVCVESIDSTHLFLCEQIRNGKIDGNFAIYALEQTNGVGSRENSWQSSKGNLHLSFCIKEEDLPKDLPLASVSIYFAYLLKELLQEKGSKIWLKWPNDLYLDDKKAGGVISAKISNFIIGGMGLNLKFSPQNTALCDIEILLKDLVSEFLQKVEKKILWKNIFSKYMLEFEKSRKFSVHHEGKVFSLENSFLYEDGSILLGDKRVYSLR55 90 26 255 64 490 Core carboxylase] synthetase methionyl-tRNA Cj0098 fmt J MKKIIFMGTPSYATCILKALVENENFKLVALFTQPDKAVGRKQILTPSDTKAFLSQNYPSIPIFTPSSLKDKNIIREIKDLNPDFIVVAAYGKILPKAILDLAPCVNLHASLLPKYRGASPIQSAILNKDEKSGVCTMLMEEGLDTGAILESLECDIKDKNSSEVFELLANLAAKLILSTLLNFDKITPKKQEESLATLCRKIKKEDGLINLQNARELYQKYLAFTPWPGVFLENGLKFLELELVDELKQNARMGEILELEKESFLLACKQGVLRIKKLQESGKKALDGRTYLNGKRLKSEDSLC55 90 26 255 64 490 Core formyltransferase GTP-binding protein, Cj0096 obg S MFIDSVKITLASGDGGKGAVSFRREKHVPLGGPDGGDGGNGGDIIFVCDNNTHTLVNFKGKRELRAQNGAGGMGRNKNGKKGENLELIVPEGTQVIDAQTNEILLDLTEEGQRELFLKGGKGGLGNTHFKHATNQRPDYAQPGIKGESRLVRLELKLIADVGLVGFPNVGKSTLISVVSNAKPEIANYEFTTLTPKLGLVDVNEYNSFVMADIPGIIEGASGGKGLGLAFLKHIERTSFLLFVLDPMRQMPLKEQFIVLRKELEKFSNELFGRKFGIMISKSDSVRLGEEFAEQIALNINELDNYLKEINNPQSFLIKVSSLEKTGLKELKFMLLEEIKTLRNNKKNFNNLGSVLY55 90 26 255 64 490 Core GTP1/Obg family Cj0093 - putative periplasmic protein M MKIIKILFLGLFLSLSLNAKVITTTSTKSSTGEGTGLTREDAINNAIIEAIGKMSGVSINSLKKSNTSVSTDNSGSNIQDNYSEQISKATKGRADTYEINSVEQDANGKYTANVTIFKTTTTKKYQAPGLSADNRRSITVFDSTPDAAKRGIGSALQQKIISDLLQSRKFNVLDRDSSGYYEMEKALIKSGDAASDEVYKLKNMLATDYILLFSISGLEGKQKTSNLTGKSKTEIEVIVDYRVLLFATRQIKFSNTLSMKVNLKDNSLSANETALKQIANRIAGDILNAIYPLKVASVENNEVIFSQSLNQGDVYECFALGKVIKDTYTKENTGRVESKTGSIEITRTSPKFSYAKITEGSVKVGDICRPLSNTGSGNGYTIGRDANYQTQEGGGVNLGF55 88 26 214 42 425 Accessory Cj0089 - putative lipoprotein S MKIKVGLIFSGIVCLFLTACVNQVKQNTTFENALTQKYCGDDFFNQNLEKIKKNDDVIYTGLNAGLIARNCGDFNKSNVFFDAAEESYKYDVDLENVGSKAAKFVGTTLLNDTIVDYDGSLYERIMVNIYKALNYMEEDDYENARVEFNRALMRQDKAKEYFAKEIEKNRADLDKAKEDKNYDKNMNENSKVIEEQYDNLFKEFDTTKNFINPYATYLASIFFFMDKDYRKAADLFREVAIIYPKNKTIKKEAKIFKEYATKIKVKKAKKYVFVVYENGFGVVKDEFALTLPFIVDKKIISTNIALQTLKKREASFANLNINNQNTNDFVDLDNIVATEFKINMPAMIAKALAQTIIKTTLNVAVANNDSTGGWLSLATAVATAATNKADVRSWRGLPKSIAIATIENDGNLEIKDPQGNILFQKSLDKNKNALVIVRSFAPYVPASVAIMEK55 90 26 255 64 490 Core anaerobic C4-dicarboxylate Cj0088 dcu A U MDIMIILQVIVLLGAIFIGIRLGGIAIGYAGGLGVVILGLVLGMKPGNIPWDVILIIAAAIAAISAMQQAGGLDYMVRVTEKILRSSPKFINYLAPACGWLLTILAGTGNAVFSLMPVVVDVAKSQNIKPSVPLSLMVVSSQIGITASPVSAAVVYMSGVLEPLGWNYPTLIGIWISTTFIACMLTAFIVSLITPMDLSKDSVYQERLKAGLVKDAGAILHGEDKPGAKLSVGIFLITVLAVVLYATAISSNIKWIDPVVVPRDAAIMSFLLTAATLITWLCKVEPGKILDTSVFKSGMTACVCVFGVAWLGNTFVAGHEASIKEVAGDWVKQTPAMLAVAFFFASMLLYSQAATAKAIVPVIITALGISAANPHDSYMLVACFAAVSALFVLPTYPTLLGAVQMDDTGTTRIGKFIFNHSFFIPGVLAIAIAVALGFVLAPMLI55 88 26 221 62 452 Accessory transporter Cj0087 asp A aspartate ammonia-lyase E MGTRKEHDFIGELEISDEVYYGVQTFRAVENFDISHDRLKDFPRFVRALARVKKAAAMANHELGLLDKNIQDAIIKACDKILEGGYYDQFVVDMIQGGAGTSTNMNANEVIANIGLELMGHKKGEYQYLHPNDHVNLSQSTNDAYPTALHLALHDYLSDLAKAMEHLKKAYERKAEEFKDVLKMGRTQLQDAVPMTLGREFKTFAVMIGEDIQRVLEARKLILEINLGGTAIGTGINSHPDYPKVVERKIREVTGFEYTVAEDLIEATQDTGAYVQISGVLKRVATKLSKVCNDLRLLSSGPKCGLNEINLPKMQPGSSIMPGKVNPVIPEVVNQVCYFVIGADVTVTFACEGGQLQLNVFEPVAAYSLFNSIVMLEKAMYTLADKCIDGITANEKICSDFVYNSVGIVTALNPYIGYENSASIAKEAMNTGKRVADIVLERGLLSKEQIDEILTPSNMLNPHMEAKK55 90 26 255 64 490 Core Cj0086c ung uracil-DNA glycosylase L MEEITINIDKIKINDDWKEFLRDEFQKKYFLEIKKQYLNAINQNIIIYPPANLIFNAFNLCPLKEIKIIILGQDPYHQPNQAMGLSFSVPKNVKIPPSLNNVFKELQNDLNITPAKSGDLSSWAKQGVLLLNSILSVEANKAASHSSWGWQEFSDAIIHKLSNEKSGLVFMLWGNYAKSKEILIDNTKHLILKAAHPSPLARTGFLGCKHFSKANEFLKKVDKIPIDWKIV55 90 26 255 64 490 Core

Cj0085c rac D putative amino acid recemase M MKTIGIIGGMSFESTITYYKTINQAINDKLKSLNSAKILLYSVNFEEIENLQSQDKWQEAAQILTQCAKKLELAGANFIIIATNTMHKVFDEIQQNINIPILHIAKSSAKALKQENIQKIGLLGTKYTMTQDFYKKILIEENISVITPSDEDIKIVNDIIFNELCKGEIKQDSKEKYLNIINKLQEKGAKGVLLACTEIGLLISKNDTNIKIFDTSLIHALDAANEALKDL36 90 26 187 28 367 Accessory cytochrome bd oxidase Cj0082 cyd B C MFFGLELEGLQIYWWLILSLLGGLLVFMFFVQGGQTLIDELSKDELEKTMLVNSLGRKWELGFTTLVLFGGAAFAAFPLFYSASFGGAYWAWLCILFCFILQAVAYEYRKKENNVYGSKTYEIFLKINGYLGVFLIGVAVSSFFSGSEFILNEHNFVSWQNPLHGLELLLNPFNYLLGLALVFLARLLGAAYFMNNINDENIKIRVMKKLMINSILFLPFFLGFLAWIFLKDGFSVDTNGVVSMSANLYLYNFLNQMIFAVLLVIGVILVLLGMVQGTKGCSKAIFTLGLGTVLTVFALLSSIGLGQSAFYPSLSDLQSSLTLKNASSSYYTLSVMAYVSLLVPFVLTYIIYVWNAMDKVKITREEIANDDHAY55 90 26 255 64 490 Core subunit II Cj0076c lld P L-lactate permease C MEQILTWQQIYDPFSNIWLSALVAFLPILCFLVCLVVLKLKGYQAGFLTVILATLVALFAYKMPWNLVGASFIQGFTNGMWPIAWIIIAAIFLYKLSIKSGSFEIIKKSVMSITPDHRIQVILIGFCFGSFLEGAIGFGGPVAITAALLVGLGLRPLQAAGLCLIANTAPVAFGAVGIPIIAMANLVGIEQHSVSAMVGRMLVPLSLTIPFFIVFLMDGFKGIKETFPAILVAALSFTTTQFLSSNHLGAELPDIISAVVSLAVTTVFLKFWKPKNIFRFDNESNFTQDNTLSFNQILKAWSPFILLIVCIIIWTQPWFKALFDKDGILSYTSITLQFSNITTGILSPSITGIGEAKPLSLALGVDLINGKTVAQAGTAILLAAFLTIAILKIKAEDAAECFWVTLKEMAIPCITIGLVVAFAFISKNSGMSTTLGLAFAHTGDAFSFFSPIIGWIGVFLTGSDTSANLLFGTLQQVSAQKLGISEALFLAANSVGGVVGKMISPQSIAIACAAVGLVGKESDLFKFTLKYSVAFIILIGIWTCIIAFFLQGIIPEVIVK54 87 1 254 64 460 Accessory Cj0197c dap B dihydrodipicolinate reductase E EAAKNATLAHGLVAKKYKFNKNSFDALKLIKGLKCL55 90 26 255 64 490 Core amidophosphoribosyltransfera Cj0196c pur F F RKFSQNYDCVLVLKGANPIIVQKEKLFVVNLGNQALAKGGSGDVLSGMIAAHLGFGFSAL55 90 26 255 64 490 Core se flagellum-specific ATP Cj0195 fli I NU QNTPLILDANCFLSEALLWYLNRKDVVITPHPKEFIKLYKMCFDENLDIETLQKNRFFYA55 90 26 255 64 490 Core synthase trigger factor (peptidyl-prolyl Cj0193c tig cis /trans isomerase, D SAGTLAGLGALNFGAGLVSLVAQKSFSPLLMLKEKIENNASAIALGMGLENLDFLKDEIL55 90 26 255 64 490 Core chaperone) ATP-dependent Clp protease Cj0192c clp P O EDFAKEFVGRIKIANLGIRSKKFYPNSQAFLLEKKDLKTIDRKINANKGNFGHIYIVANA55 90 26 255 64 490 Core proteolytic subunit Cj0191c def polypeptide deformylase J CILGTGSNRCLDEKTSLIIQKVNQSKALKIACDIPTNLGFYPCFKADITFCMGALKEILL55 90 26 255 64 490 Core Cj0189c - hypothetical protein S GGNNASDGLVALRNLKHAKAYKIGFKENTLFKKQEQILQNYAFKFCKKEPNFKKFHIIID55 90 26 255 64 490 Core Cj0188c nnr D putative kinase - MKAIIDNIKILKQNAINKGLDELILMENAGLNLAKLIKKEAKKIRIQRKIRKVKILFLLG55 90 26 255 64 490 Core

Seite 7 Table S3 (Cattle)

Ser/Thr protein phosphatase Cj0184c - T MRILLVLRGNYYAGQEEFIKNNKLQNYTLDLNALRLLSGSVKNIVSEYKILNVKNDEDLSKILLKLLEMRMQKGEFSIINAYNETLKIYKDLAKQYRYKIYVIVFDSSLKQCQEKNLLEAKKNGYIIPYALLEKTQDLLKKNPKKYPILDSRDWKKCLYQMPNLSKYKKIHHIGDLQGCYSVLKEYIKTIKEDEFYIFLGDYINRGIENGKVIKFLLKICEKENVCLLEGNHERHLIKWANGELSNSKEFNENTLKDFRKEKLTPRDARKLYPHLKECLYYKFQNKFIFCSHGGVNFIPSKPEKISFIPSHDFIYGVGGYEDSQKIANQFCNFTSDNLYQIFGHRNKEKLPMKIAKRVFLCEGKIDDGGYLRVVTLDKKGFECIEIKNQIYKKK55 90 26 255 64 490 Core family protein putative integral membrane Cj0183 cor C protein with haemolysin S MDPSQVLDLNQTSTASFDAGYSMLMVVVALALVFLNGFFVLSEFSIVKVRRSKLEEMVKEKKAGAKKALEVTSRLDTYLSACQLGITLSSLALGWIGEPAIAKMLEIPLINLGFSTVIIHTIAFIIAFSIITLLHVVLGELVPKSIAIAVADKAVLFIARPLHWFWMLFLPCIKIFDFLAAISLKLFGIKPAKESELTHSEEEIKIIASESQKGGVLDEFETEIIRNAVDFSDTVAKEIMTPRKDMICLNKQKSYEENMQIICEHKHTRFPYIDGSKDTILGMIHIRDIIQNELNHKSQNLDTFVKPLILVPENISISKVLVMMNKERSHTALVVDEYGGTAGILTMEDIMEEIIGEIKSEHEEDSYKKLAENIYEFQGRCDIETVEEMLVINYDEDLEQVTIGGYVFNLLGRLPMVGDRIEDELCYYEVKKMDGNSIERVKVVKKTNKDEE55 90 26 255 64 490 Core domain protein putative transmembrane Cj0182 sbm A I MFSSFFKSKKWALWAYLGLFLLLFFLFIQTSLNVAINSWYSDFYNVLQKPKIELLDSNSTQKIEENLENNATLIQEANQRAEQNFQKANFINKGALYYYQNLLEYFFNSRAMIEKPNYSANDFYALILVFLAIAIPYVLIATINIYFASVYAFKWREAMTFSYLKFWKNKDDNIEGSSQRIQEDTYNFSKIVESLGLSFIKALMTLVAFIPILWSLSDVVSKALFANLSENSFFYFLKNIDGLLVYIALLISLGGLVVSWFVGIKLPGLEYNNQKAEAAFRKELVYAEDNRKEYAKNETMIELFTGLKFNYKRLFLHYGYFNIWLILFEQMIVIVPFLIMAPGLFAGAIGLGIVMQINNAFDQVRSSFSVFITNWTTITQLRSIYKRLKEFEKNISYKS55 76 26 255 29 441 Accessory transport protein Cj0179 exb B biopolymer transport protein U MLKKMFLFCFLLLNLNAEANATDTNLSFDSSKIETKAPKIELSLSSLYQNADEVVKGVIYILVLFSILAWAVFISKLMQFYFMKKNLDLSIQKIKELKNLNELDQTKDFAGVLSLEIQDELEKSEYKNDHIKERIELRLQNTISKQITASKNGLSLLASIGASAPFIGLFGTVWGIMNAFIGIANLGNASLAVVAPGIAEALFATAFGLIAAIPAVLFYNYLTRKNLKLMHHLDELANFVYILFHRSYFNDKN36 64 0 194 14 308 Accessory putative TonB-denpendent Cj0178 - P MQNLFDKNYMDALNAYNSLDNQLQYNGAGDPIYLFSNSARGRTFIVSFEYKY34 9 0 58 6 107 Accessory outer membrane receptor putative TonB-denpendent Cj0178 - P MKKLSLFCAVGLCFASFAFSEELEFDSLEISGSKIKNDEKPFVTPGATSTREGIGSDTQSIDSIVRSIPGTYTNTDQAQGTVQVNIRGMSGFGRVNTMIDGVTQTFYGSASDDPARFHSQTGTSAFGAVIDTNFLIGVDVTRGTFEGVGGANALMGSANFKTIGINDIVHDGNIFGFLGRFSYGSNGIGPSYMSAVAGKTELENNGYVGALFGYSAKRITQNYTVGGGGKIGSSMVDTDGDGIADTNIAPFDPDFLTQKPNSQLFKLEYVPNSFTNTIFSYRRYQNELASRKIHNDNYQLDFWHNPNEWLNVNTLIAYNQGIQTYGSKSTFAANDAIANTKAKNTATTFDISDTLEGEWHRFNLNIRFGANILLNDYKNTLNTSIQGVNSIPFQPRGKQNLFTYYLDNSLNYGIFTLDTNVNLLDWNIKGHRPACDEVNFMCFPKAATDIDKNGLRLNASVMLSAAIHELFTPFVSFARTNRAPNVQEMFFSNNEGNGINPFLKPEQANTWQIGFNSFKHGLLKDDDRFGFKAVYYHTKIKDYIYNEQFYLEDPSKDPPSSQFYMHLNSADDTIFKGVELELSYDLGFAYAKAMYSRQDTSSTISQTSGPLLGSFSASKIMELPKDYANVELGFRLNDKISFGGIAKYTGKAKRVNPNTDDWNKDPNNPYYPKPTTQDLPKIPIIVDLYWNIEWFKNLTMRARGAKFI23 3 0 24 3 53 Accessory outer membrane receptor aLocus tags for accessory genes based on C. jejuni reference strain NCTC13261 genome LR134500.1 (NCBI accession) while locus tags for allelic variants of the core genome refer to C. jejuni strain NCTC11168 (NCBI accession: AL111168.1) bclusters of orthologous groups (http://clovr.org/docs/clusters-of-orthologous-groups-cogs/); cnumber of genomes assigned to a particular lifestyle carrying the gene or allelic variant (pig, cattle, chicken, host generalists, others) dindicates that a gene belongs to the accessory (A) or the core (C) genome content of C. jejuni

Seite 8