BIRTH & FUTURE OF MULTI-SCALE MODELING OF MACROMOLECULES Nobel Lectures, Stockholm 8 December 2013 Michael Levitt Structural Biology & Computer Science Stanford
http://csb.stanford.edu/levitt Michael Levitt 13 SUMMARY 1. How It All Began.
2. Birth of Computational Structural Biology.
3. Future: Multi-Scale Dynamics of Huge Systems.
4. Some General Thoughts. Michael Levitt 13 1.0 Michael Levitt 13 Michael Levitt 13 1951: PAULING THE GREAT CHEMIST
1951 The alpha-helix 1901-1994 Michael Levitt 13 1953: FRANCIS CRICK
1916-2004
DNA Model and Experiment Michael Levitt 13 1959: KENDREW AND MYOGLOBIN Scientific American 1961
1917-1997 First protein X-ray structure. Painted by artist Irving Geis Michael Levitt 13 1962: PERUTZ AND HEMOGLOBIN
The REAL HERO of 1914-2002 structural biology. Michael Levitt 13 1965: PHILLIPS AND LYSOZYME
1924-1999 Early supporter of Computational Biology Michael Levitt 13 1943-1945: LOS ALAMOS
The Birth of the Monte Carlo Method. http://trace.ntu.ac.uk/frame2/articles/borg/JvN.html Michael Levitt 13 LIQUIDS: ARGON & WATER
Aneesur Rahman 1927-1987 Argon is like a collection of Water has an open structure. hard spheres. Each Argon has Due to tetrahedral geometry, 12 to 14 neighbors. each water has 4 to 5 neighbors.
Molecular Simulation. Michael Levitt 13 SUMMARY SO FAR 1. How It All Began.
2. Birth of Computational Structural Biology.
3. Future: Multi-Scale Dynamics of Huge Systems.
4. Some General Thoughts. Michael Levitt 13 2. BIRTH OF COMPUTATIONAL STRUCTURAL BIOLOGY
4.3 Michael Levitt 13 KENDREW, ME & ISRAEL Nobel Prize in 1962 Gave TV Series in 1964 Sent me to Israel in 1967
BBC TV Winter 1964