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CARDIOLOGY European Edition Vol. 8.1 October 2020 emjreviews.com + ESC CONGRESS 2020 Reviewed + EDITOR’S PICK + INTERVIEWS In a round table interview, past Artificial Intelligence in and present ESC board members share insights from their careers, Patients with Congenital and a cardiology surgeon discusses the importance of clinical trials. Heart Disease: + ABSTRACT REVIEWS Where Do We Stand? Reviews of fascinating abstract summaries of research presented at ESC Congress 2020. Contents + EDITORIAL BOARD 4 + WELCOME 7 + FOREWORD 9 + CONGRESS REVIEW Review of the European Society of Cardiology (ESC) Congress 2020, 10 28th August–1st September + CONGRESS FEATURES 2020 ESC Guidelines on Sports Cardiology and Exercise in Patients 23 with Cardiovascular Disease Anaya Malik + SYMPOSIUM REVIEWS Therapeutic Advances in Patients with Heart Failure with Reduced 26 Ejection Fraction Who Have Had a Previous Worsening Heart Failure Event + POSTER REVIEWS New Insights into Icosapent Ethyl for Patients with Residual 34 Cardiovascular Risk First Clinical Validation of the 0-Hour/1-Hour Algorithm Using High- 42 Sensitivity Cardiac Troponin I for the Diagnosis of Acute Myocardial Infarction in Japanese Patients + ABSTRACT REVIEWS 45 + CONGRESS INTERVIEW 56 Dan Atar, Stephan Achenbach, and Jose Zamorano 2 CARDIOLOGY • October 2020 EMJ "Bringing you matters topical this autumn, we present EMJ Cardiology 8.1, an issue with one purpose: to bring to our readers the very latest updates and exciting findings in the specialty." Spencer Gore, CEO + INTERVIEWS Key Findings from the EXPLORER-HCM Study of Mavacamten in 62 Obstructive Hypertrophic Cardiomyopathy: Insights from the Principal Investigator Iacopo Olivotto Rasha Al-Lamee 67 + ARTICLES Editor’s Pick: Artificial Intelligence in Patients with Congenital Heart 70 Disease: Where Do We Stand? Pool et al. Sex Differences in Heart Failure with Preserved Ejection Fraction 82 Therapy: Potential Mechanisms and Clinical Implications Meyer and Beale Acute Severe Mitral Regurgitation Secondary to Haemophilus 92 parainfluenzae Infective Endocarditis Kelley et al. The Evolution and Future Direction of The Cardiac Biomarker 97 McDonaugh and Whyte High-Density Lipoproteins and Cardiovascular Disease 108 Nicholls et al. Raiders of the Lost Wire 117 Salazar et al. A Clinical Review of Ventricular Arrhythmias in Patients with 124 Congestive Heart Failure Al-Hadithi and Boyle Edge-To-Edge Repair After Prior Left-Sided Pneumonectomy 135 Abdel-Hadi et al. Creative Commons Attribution-Non Commercial 4.0 October 2020 • CARDIOLOGY 3 Editorial Board Editor-in-Chief Dr Çetin Erol Ankara University, Turkey Editorial Board Dr Pierfrancesco Agostoni Ziekenhuis Netwerk Antwerpen (ZNA) Middelheim, Belgium Prof Denilson Campos de Albuquerque State University of Rio de Janeiro, Brazil Dr Andy Wai Kwong Chan Andy Wai Kwong Chan Heart Centre, Hong Kong Prof Dr Uwe Nixdorff European Prevention Center, Germany Dr Sazzli Kasim Universiti Teknologi MARA, Malaysia Dr Ronald J. Krone Washington University School of Medicine, USA Dr Carl J. Lavie The University of Queensland School of Medicine, USA Prof Stephen Lee University of Hong Kong, Hong Kong Dr Sanjog Karla Einstein Medical Center Philadelphia, USA Prof Dr Constantine Kosmas Cardiology Unlimited, USA Dr Carl J. Pepine University of Florida, USA Prof Khai Pham Gia Bach Mai Hospital, Vietnam Dr Nicholas Kipshidze New York Cardiovascular Research, USA Dr Christian Bär Hannover Medical School, Germany Dr Amandeep Goyal Marietta Memorial Hospital, USA Prof Dr Rainer Wessely Center for Cardiovascular Medicine (CIKA), Germany VIEW IN FULL 4 CARDIOLOGY • October 2020 EMJ Aims and Scope We are always keen to hear from healthcare professionals wishing to discuss potential submissions, please email: EMJ is an online only, peer-reviewed, open access general [email protected] journal, targeted towards readers in the medical sciences. 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Editorial staff, following consultation with either a This Publication member of the Editorial Board or the author(s) if ISSN 2054-3174 necessary, identify three appropriate reviewers, who are selected based on their specialist knowledge in the EMJ Cardiology is published once relevant area. a year. For subscription details please visit: www.emjreviews.com All peer review is double blind. All information obtained by EMJ and each of the Following review, papers are either accepted without contributions from various sources is as current and modification, returned to the author(s) to incorporate accurate as possible. However, due to human or required changes, or rejected. mechanical errors, EMJ and the contributors cannot guarantee the accuracy, adequacy, or completeness of Editorial staff have final discretion over any any information, and cannot be held responsible for proposed amendments. any errors or omissions. EMJ is completely independent of the review event (ESC 2020) and the use of the Submissions organisations does not constitute endorsement or media partnership in any form whatsoever. We welcome contributions from professionals, consultants, academics, and industry leaders on relevant Front cover and contents photograph: and topical subjects. Amsterdam, Netherlands. © sborisov / 123rf.com We seek papers with the most current, interesting, and relevant information in each therapeutic area and accept original research, review articles, case reports, and features. Creative Commons Attribution-Non Commercial 4.0 October 2020 • CARDIOLOGY 5 EMJ Cardiology 8.1 Chairman of Advisory Board Head of Operations Prof Jonathan Sackier Keith Moule Chief Executive Officer Operations Assistants Spencer Gore Satkartar Chagger, Emma Knight Senior Project Director Editor Daniel Healy Evgenia Koutsouki Chief Operating Officer Deputy Managing Editor Dan Scott Sam Davis Head of Publishing Content Manager Hamish Dickie Kirstie Turner Head of Content Marketing Editorial Assistants Sen Boyaci Lenos Archer-Diaby, Michaila Byrne, Katherine Colvin, Rachel Donnison, Anaya Malik, Isabel Head of Commercial O’Brien, Layla Southcombe Michael McConaghy Design Manager Performance Managers Stacey Rivers Darren Brace, Robert Hancox Graphic Designers Senior Project Managers Roy Ikoroha, Emma Rayner Hayley Cooper, Nabihah Durrani, Millie McGowan, Max Roy Junior Designer Steven Paul Project Managers Emilie De Meritens, Tilly Flack, Mary Gregory, Digital and Data Innovation Manager Antonio Grier, Rebecca Harrison, Andrew Louis Jonesco Hodding, Mark Kirwan, Lewis Mackie, Thomas Marketing Coordinator Madden, Jack Moore, Mariana Napoleao, Billy Noah Banienuba Nicholson, Aleksandar Popovic, Alexander Skedd, Caleb Wright Executive Assistant Nikki Curtis Sales Administrator Simi Ige Head of Recruitment Karen Lee Head of Client Services Courtney Jones Head of Finance Emma Cook 6 CARDIOLOGY • October 2020 EMJ Welcome Dear Readers, Bringing you matters topical this autumn, we present EMJ Cardiology 8.1, an issue with one purpose: to bring to our readers the very latest updates and exciting findings in the specialty. Cardiology has had its fair share of the medical spotlight this year, with the management