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Volume 3 (4) 2017 RESEARCH RESULT: PHARMACOLOGY and CLINICAL PHARMACOLOGY Volume 3 (4) 2017 RESEARCH RESULT: PHARMACOLOGY AND CLINICAL PHARMACOLOGY The journal has been registered at the Federal Service for Supervision of Communications, Information Technology, and Mass Media (Roskomnadzor) Mass media registration certificate El. № FS 77-55674 of October 28, 2013; El. № FS 77-69077 of March 14, 2017. The journal is supported by the Russian Scientific Society of Pharmacologists (RNOF), the Association of Clinical Pharmacologists of the Russian Federation, and is published in cooperation with the Association of Scientific Editors and Publishers (ASEP). Volume 3, № 4. 2017 ONLINE SCHOLARLY PEER-REVIEWED JOURNAL First published online: 2015 ISSN 2500-235X EDITORIAL TEAM: EDITOR-IN-CHIEF: Mikhail V. Pokrovskii, Academician of the Russian Academy of Natural Sciences, Doctor of Medical Sciences, Professor, Head of the Department of Pharmacology, Institute of Medicine, Belgorod State National Research University, Russia. Expert in experimental pharmacology and history of pharmacology, member of the Association of Scientific Editors and Publishers (ASEP). DEPUTY EDITOR-IN-CHIEF: Pavel A. Galenko-Yaroshevsky, Corresponding member of the Russian Academy of Sciences, Doctor of Medical Sciences, Professor, Kuban State Medical University, Russia. Expert in experimental pharmacology. EXECUTIVE SECRETARY: Tatyana V. Avtina, Сandidate of Pharmaceutical Sciences, Associate Professor, Department of Pharmacology, Institute of Medicine, Belgorod State National Research University, Russia. Expert in drug pharmacokinetics research. ENGLISH TEXT EDITOR: Igor Lyashenko, Candidate of Philology Sciences, Associate Professor, Department of English Philology and Intercultural Communication, Institute of Intercultural Communication and International Relations, Belgorod State National Research University. Expert in proofreading of English articles and texts. EDITORIAL BOARD: Branislava Miljković, PhD, Professor, Department of Pharmacokinetics and Clinical Pharmacy, University of Belgrade, Belgrade, Serbia. Expert in clinical pharmacology. Dmitry E. Skopin, Doctor of Physical and Mathematical Sciences, Professor, Al Balqa Applied University, Jordan. Expert in biomedical statistics and digital processing of biological signals. Elena B. Artyushkova, Doctor of Biological Sciences, Professor, Director of the Research Institute of Environmental Medicine, Kursk State Medical University, Russia. Expert in the field of biological research methods in pharmacology. Evgeny A. Konorev, Doctor of Medical Sciences, Professor, University of Kansas City, USA. Expert in preclinical drug research. Konstantin M. Reznikov, Honored Scientist of the Russian Federation, Doctor of Medical Sciences, Professor, Department of Pharmacology, Voronezh State Medical University named after N.N. Burdenko, Russia. Expert in experimental pharmacology. Lev N. Sernov, Honored Scientist of the Russian Federation, Doctor of Medical Sciences, Professor, General Director of "Farmkonsalting", Russia. Expert in the field of molecular screening of innovative molecules. Mikhail V. Korokin, Doctor of Medical Sciences, Professor, Department of Pharmacology, Institute of Medicine, Belgorod State National Research University, Russia. Expert in the field of pharmacology of innovative medicines. Natalia D. Bunyatyan, Doctor of Pharmaceutical Sciences, Professor, Deputy Director General for Research Federal State Budgetary Institution «Scientific Center for Expertise of Medical Application Products» of the Ministry of Health of the Russian Federation, Russia. Expert in the field of pharmacological methods in pharmaceutical research. Oleg S. Gudyrev, Сandidate of Medical Sciences, Associate Professor, Department of Pharmacology, Institute of Medicine, Belgorod State National Research University, Russia. Expert in preclinical drug research. Radica Stepanović-Petrović, PhD, Full Professor, Department of Pharmacology, University of Belgrade, Belgrade, Serbia. Expert in preclinical drug research. Sergei Y. Shtrygol, Doctor of Medical Sciences, Professor, National University of Pharmacy, Ukraine. Expert in Clinical Pharmacology. Svetlana Ibrić, PhD, Vice-dean for science and international relations of the Faculty of Pharmacy, Department of Pharmaceutical Technology and CosmetologyBelgrade, University of Belgrade, Serbia. Expert in pharmacology, pharmaceutical technology. Tatyana A. Savitskaya, Сandidate of Chemistry Sciences, Professor, Department of Physical Chemistry, Belarusian State University, the Republic of Belarus. Expert in the field of chemistry and structure of action of biologically active substances. Tatyana G. Pokrovskaya, Doctor of Medical Sciences, Professor, Department of Pharmacology, Institute of Medicine, Belgorod State National Research University, Russia. Expert in clinical pharmacology. Zorica Vujić, PhD, Dean of the Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Belgrade, Belgrade, Serbia. Expert in the field of pharmacological methods in pharmaceutical research. Founder: Federal State Autonomous Educational Establishment of Higher Professional Education «Belgorod State National Research University» Publisher: Belgorod State National Research University Address of publisher: 85 Pobeda St., Belgorod, 308015, Russia Publication frequency: 4 /year © Belgorod State National Research University, 2017 RESEARCH RESULT: PHARMACOLOGY AND CLINICAL PHARMACOLOGY CONTENTS EDITORIAL Pokrovskii M.V., Avtina T.V., Zakharova E.V., Belousova Yu.V. Oswald Schmiedeberg – the “father” of experimental pharmacology 3 EXPERIMENTAL PHARMACOLOGY Bibik E.Yu., Saphonova A.A., Yeryomin A.V. , Frolov K.A., Dotsenko V.V., Krivokolysko S.G. Study of analeptic activity of tetrahydropyrido [2,1-b] [1,3,5] tiadiazine derivatives 20 Bogus S.K., Suzdalev K.F., Uvarov A.V., Galenko-Yaroshevsky P.A., Vasil'ev P.M., Vinakov D.V., Kiseleva N.V., Kochetkov A.N., Kiselev A.V. Anti-inflammatory and analgesic propertiesof SS-68 indole derivative 26 Denisiuk T.A. Pharmacotherapeutic strategies for endothelial dysfunction correction with use of statines in syndrome of systemic inflammatory response 35 Dovgan A.P. Ligand of peripheral imidazoline receptors based on amides of heterocyclic acids C7070: effect on ishemized tissues 78 Efremova M.P., Ivasheva A.V., Korokin M.V. Study of pharmacological activity of Nigella damascena fixed oil in experiment 89 Miroshnichenko A.G., Perfil'yev V.Yu., Lysenko I.V., Zhernakova N.I. Interaction between some antibiotics and antioxidants 100 Peresypkina А.А. Correction of retinal angiopathy of hypertensive type by dimethylaminoethanol derivative 19-16 in experiment 113 Razumova M.S., Litvinova E.S., Gavriliouk V.P. Study of pharmacological activity in sublimated culture liquid of allogenic, xenogeneic hepatocytes and fibroblasts for the correction of liver damages in carbon tetrachloride intoxication 120 Tarasova A.P., Danilenko L.M., Sernov L.N. Effect of pharmacological preconditioning with incretinomimetics exenatide and vildagliptin on the survival of ischemic tissues 132 Voronkov A.V., Gamzeleva O.Y. The effect of new forms for external application on the vasodilating function of the endothelium and the concentration of endothelial nitric oxide synthases in rats with an experimental model of a pathological scar at early healing times 151 CLINICAL PHARMACOLOGY Zemskova V.A., Zoloedov V.I., Popova O.A. Optimization immunepharmacotherapy of pyoinflammatory diseases 160 December. 2017. 3(4). Research Result: Pharmacology and Clinical Pharmacology rrpharmacology.ru Pokrovskii M.V., Avtina T.V., Zakharova E.V., Belousova Yulia V. Oswald Schmiedeberg – the “father” of experimental pharmacology. Research Result: Pharmacology and Clinical 3 Pharmacology. 2017;3(4):3-19. EDITORIAL Rus. UDC: 615:378 DOI: 10.18413/2313-8971-2017-3-4-3-19 Mikhail V. Pokrovskii1 Tatyana V. Avtina T. OSWALD SCHMIEDEBERG –THE “FATHER” OF Elena V. Zakharova EXPERIMENTAL PHARMACOLOGY Yulia. V. Belousova Belgorod State National Research University, 85 Pobedy St., Belgorod, 308015 Russia Corresponding author, 1e-mail: [email protected] “Our tribute to the memory of the Teachers and those who were pioneers of pharmacology is an invaluable gift to our descendants” Abstract Biography. Oswald Schmiedeberg (1838-1921) was a son of a bailiff and a maid of honour, the eldest of the six children in the family. He was born and educated in the Russian Empire. Scientific activity. All his life he was completely devoted to science, making experimental pharmacology an independent scientific discipline, and was able to bring it to the international level. O. Schmiedeberg studied the action of muscarine and nicotine, digitoxin, hypnotics and analeptics. He was the first to introduce the concept of ―pharmacodynamics‖ and ―pharmacokinetics‖ of a drug. With his participation, the world‘s first pharmacological journal was founded, which is still published today. Science school. Working for many years at the University of Strasbourg, Schmiedeberg managed to educate about 120 students – professors from 20 countries of the world, many of whom later founded experimental pharmacology in their countries, for example, Abel in the USA, and N.P. Kravkov in Russia. Scientific activity of Schmiedeberg influenced scholars of his time and for generations to come, creating the preconditions for new high-profile discoveries and even for receiving Nobel prizes. But Oswald Schmiedeberg failed to obtain this high award himself, though he had been nominated 14 times. Biography Gertrude Borchet. He worked
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