Cancer Discovery & Care

0 UPMC Cancer Centers and University of Pittsburgh Cancer Institute 1 0 2 , 1 . o N , 6 . l o V

DISCOVERY & CARE

From disaster to breakthrough: UPMC pathologist pioneers radiation and thyroid cancer link UPMC Cancer Centers and University of Pittsburgh Cancer Institute

The University of Pittsburgh Cancer Institute, working in conjunction with UPMC Cancer Centers, UPMC’s clinical care delivery network, is western Pennsylvania’s only National Cancer Institute (NCI)-designated Comprehensive Cancer Center, reflecting the highest level of recognition by NCI.

DISCOVERY & CARE Cancer Discovery & Care is a publication of UPMC Cancer Centers and the University of Pittsburgh Cancer Institute (UPCI) and is produced by UPMC Clinical Marketing. © Copyright 2010 UPMC. All rights reserved. No portion of this magazine may be reproduced without written permission. Send suggestions, comments, or address changes to Amyjo McDade at UPCI/UPMC Cancer Centers, Office of Communications, UPMC Cancer Pavilion, 5150 Centre Ave., Room 457a, Pittsburgh, PA 15232, or via e-mail at [email protected] . Contents

From disaster to breakthrough 4

Building relationships to fight cancer 8

Remembering Jeffrey E. Shogan, MD 12

Charity starts at home 14

The power of partnership 18

News briefs 24 UPMC Cancer Centers and University of Pittsburgh Cancer Institute Executive Leadership

Nancy E. Davidson, MD Maryann Donovan, PhD, MPH Colleen McCabe Mantini, MPA Director Associate Director for Research Services Director of Government Relations and Advancement Stanley M. Marks, MD Joel Nelson, MD Director of Clinical Services and Peter G. Ellis, MD Program Director, Prostate Cancer Program Chief Medical Officer Deputy Director of Clinical Services and Associate Chief Medical Officer Jennifer M. Raetz James G. Terwilliger Development Director Executive Vice President Susan Frank, RN, MSN Director of Clinical Operations, Shivendra V. Singh, PhD Peter D. Tate Hillman Cancer Center Director of Basic Research Chief Financial Officer Laura Gailey-Moul Clayton Smith, MD, FRCPC David L. Bartlett, MD Vice President of Operations Director, Hematological Malignancies Co-Director of Surgical Oncology Program and Leukemia and Stem Cell Services and Chief of the Division Vijaya C. Gandhi, PhD, MBA Clinical Transplant Services of Surgical Oncology Associate Director for Administration and Strategic Planning Bennett Van Houten Michael J. Becich, MD, PhD Leader, Program of Molecular Associate Director for Cancer Informatics Jennifer Ruben Grandis, MD, FACS and Cellular Cancer Biology Program Leader, Dana Bovbjerg, PhD Head and Neck Cancer Program Director of Biobehavioral Medicine Program Dwight E. Heron, MD Adam M. Brufsky, MD, PhD Director of Radiation Oncology Services Associate Director of Clinical Investigations James D. Luketich, MD Edward Chu, MD Co-Director of Surgical Oncology Chief of Division of Hematology/Oncology Services and Chair, Department of and Deputy Director of UPCI Cardiothoracic Surgery

UPCI Council

Sy Holzer, Chair Douglas P. Dick Sally Levin Cynthia Roth Elsie H. Hillman, Vice Chair George A. Fechter Jeffrey Lipton Susan C. Santa-Cruz Curtis Aiken Lee B. Foster II David J. Malone Frederic B. Sargent Thomas J. Balestrieri John P. Friel Kevin McClatchy Dan Shapira G. Nicholas Beckwith III Chip Ganassi Leslie Merrill McCombs Robert Slagle James Broadhurst Thomas B. Grealish Susan P. McGalla Sandy Snyder Carlos M. Cardoso Joseph Haleski Martin G. McGuinn Stephen R. Tritch Frank Coonelly Roy W. Haley Katie McSorley Thomas VanKirk Harriet Crawford I. N. Rendall Harper Jr. David Morehouse Jack Wagner Randall L. Crawford Mark Hart Eugene J. O’Sullivan John Weinstein Barbara Crown Dawne Hickton Arnold Palmer Michael Zamagias Nicholas Deluliis Bill Isler Bradley Penrod Joseph W. DeNardo William Kassling Sen. John R. Pippy Robert C. Denove Mario Lemieux Jane Roesch

2 University of Pittsburgh Cancer Institute The Power of Partnership a future without cancer

Cancer research has always been ground-breaking science, with discoveries coming in many forms for preventing, detecting, treating, and defeating this devastating disease.

At the University of Pittsburgh Cancer Institute (UPCI) and UPMC Cancer Centers, our mission has been to accelerate the transition of our scientific endeavors from the lab to the bedside — or, in other words, to enable our patients to benefit from our research in the fastest time frame possible.

Our UPCI physician-researchers are on the frontlines of translating scientific discovery into everyday clinical practice. Their innovative work already is changing the way cancer is detected and treated.

One example of this progress is the work of UPCI researcher Yuri Nikiforov, MD, PhD, who is featured in this issue. Dr. Nikiforov used his experience in the former Soviet Union to feed his fascination with the relationship between exposure to radiation and the development of thyroid cancer. Now, the fruits of his unique molecular research have been borne out in the development of tests that can detect cancer in cells that appear benign , Our UPCI physician-researchers are and may, in the future, predict a person’s susceptibility to develop on the frontlines of translating scientific thyroid cancer after radiation exposure. discovery into everyday clinical practice . Our researchers are making progress in this field every single day. But to continue making these kinds of strides in advancing scientific discovery, we must rely on the support of our Pittsburgh family — the patients and relatives, business and community leaders — who contribute their time, treasures, and talents to helping our institution grow and prosper. And thanks to that family, UPCI now begins its 25th year, and will commemorate this achievement throughout the 2010-2011 academic year.

As we celebrate this significant milestone in our institution’s history, we also celebrate the milestones that have been achieved in cancer research and care over the past quarter century. Along that path, our understanding of cancer has advanced thousandfold, and more people are alive today because of our increased knowledge of this disease. But this journey must continue.

I look forward to continuing our partnership as we work toward a future without cancer.

Nancy E. Davidson, MD Director, University of Pittsburgh Cancer Institute and UPMC Cancer Centers Associate Vice Chancellor for Cancer Research Hillman Professor of Oncology Professor of Medicine University of Pittsburgh School of Medicine

UPMC Cancer Centers 3 From disaster to breakthrough: UPMC pathologist pioneers radiation and thyroid cancer link

4 University of Pittsburgh Cancer Institute “In a tragic way, Chernobyl was a unique opportunity for us to freely understand the biology of radiation.”

Yuri Nikiforov, MD, PhD

n 1986, Yuri Nikiforov, MD, PhD, was a pathologist and than 10 million people potentially exposed to radiation in the researcher at a pediatric hospital in Minsk in the former air, grass, and drinking water, why did such a disproportionate Soviet Union when Reactor Number 4 exploded at the number of people present with thyroid cancer? Chernobyl nuclear power plant, spewing radioactive isotopes Dr. Nikiforov’s career path would eventually lead him to UPMC Iinto the air. Millions of people in surrounding countries were as a premier pathologist in understanding thyroid cancer, and exposed to high doses of radiation. Four years after the accident, developing state-of-the-art diagnostic procedures that have become Dr. Nikiforov began diagnosing an unprecedented number of standard practice when diagnosing the disease. Dr. Nikiforov thyroid cancers in patients who had been exposed to radiation works with UPMC’s Multidisciplinary Thyroid Center and the as a result of the Chernobyl accident. University of Pittsburgh Cancer Institute (UPCI) to pioneer As criticism over the Soviet Union’s initial mishandling of the efforts in developing novel strategies for earlier diagnosis, more disaster dissolved, Dr. Nikiforov had only begun to answer a effective treatment, and the prevention of thyroid cancer. lingering medical question posed by the tragedy. With more Continued

UPMC Cancer Centers 5 Identifying the Inherited Risks Similar tragedies in Hiroshima and Nagasaki, Japan, suggested “The panel of genetic a link between radiation exposure and thyroid cancer; however, due to a lack of specific technology at the time, little was markers really helps understood of the connection. “In a tragic way, Chernobyl was to make for a more a unique opportunity for us to freely understand the biology of specific and accurate radiation and how radiation induces cancer in children and adults,” says Dr. Nikiforov. “We hoped to find a way to minimize or diagnosis of cancer completely prevent the carcinogenic effects of radiation.” in thyroid nodules.” Dr. Nikiforov and his team began to investigate and understand the genetic markers related to thyroid cancer. He identified specific mutations that occur in the RET and BRAF genes as a result of radiation exposure. we knew who was predisposed to radiation-induced cancer, oncologists may recommend a different treatment plan to Research has shown that the presence of each of these mutated prevent the patient from developing a secondary cancer,” genes plays a role in the development of cancer. Dr. Nikiforov says Dr. Nikiforov. This discovery could also lead to a future discovered that damage induced by radiation forces activation screening tool that could determine who has the least risk of of the RET and BRAF genes, leading to tumor development in developing radiation-induced cancers in work environments, the thyroid. The BRAF gene mutation is an indicator of the such as nuclear power plants and the NASA space program. aggressiveness of the thyroid cancer. Knowing how aggressive a cancer is may affect a patient’s treatment plan, allowing surgeons Looking Beyond the Microscope to determine how extensive tumor removal should be. Dr. Nikiforov’s research transcends the barriers of the lab and holds major clinical applications for the more than 38,000 people Today, Dr. Nikiforov’s research focuses on discovering how each year diagnosed with thyroid cancer. Endocrinologists certain inherited genetic features make a person susceptible to traditionally diagnose thyroid cancer using fine needle aspiration developing radiation-induced cancer. A mutation of the RET (FNA), which involves removing cells from a nodule using a gene may indicate a person’s high susceptibility to radiation- thin needle. Pathologists review this sample under a microscope induced thyroid cancer. to determine if the cells are malignant or benign. For patients In the aftermath of the explosion at Chernobyl, approximately with inconclusive results, the tumor cells can be studied against 1 million children were exposed to significant doses of radiation; Dr. Nikiforov’s identified genetic mutations to better determine approximately 4,000 developed thyroid cancer. “This demonstrated the likelihood of cancer. “The panel of genetic markers really an inherited predisposition to cancer,” said Dr. Nikiforov. An helps to make for a more specific and accurate diagnosis of eventual unraveling of a genetic code that leads to increased cancer in thyroid nodules,” says Dr. Nikiforov. These novel cancer susceptibility could benefit cancer patients who would genetic markers can be used to diagnose a cancer even if the typically consider radiation therapy as a treatment plan for their thyroid cells appear benign under the microscope. cancer. “This has profound implications,” says Dr. Nikiforov. “If Dr. Nikiforov’s genetic testing is recognized as an effective method of diagnostics by the American Thyroid Association. At UPMC’s Multidisciplinary Thyroid Center, patients have access to this state-of-the art molecular diagnostic evaluation from its pioneering source.

Dr. Nikiforov remains interested in uncovering additional markers that will definitively determine if a tumor is malignant or benign. The National Cancer Institute has awarded Dr. Nikiforov a $1-million grant to continue his research with UPMC and to identify new genetic markers and understand the reason for the rapidly growing incidence of thyroid cancer in the United States. Additional findings could ultimately change the future of cancer care and diagnosing cancer for thousands worldwide.

6 University of Pittsburgh Cancer Institute “Because of this genetic testing, we were able to intervene at an early stage, long before Denise’s cancer became widespread .”

Steven P. Hodak, MD Co-director, Multidisciplinary Thyroid Center, UPMC and UPCI

Importance of Genetic Testing in the Fight Against Cancer Twelve years after Denise Murphy was diagnosed with a small thyroid would ultimately lead to a tailored treatment plan. While working nodule, she could feel a change in the size of her thyroid, despite the as a phlebotomist in an outpatient lab at UPMC Montefiore, Denise use of medication to suppress the nodule. In 2007 and 2008, had heard good things about Sally E. Carty, MD, co-director , UPMC Denise had two fine needle aspiration (FNA) procedures, both Multidisciplinary Thyroid Center, UPMC and UPCI. “I knew she had negative for cancer. an excellent reputation and I wanted to meet with her to discuss my Due to continued neck discomfort and painful swallowing, UPMC options,” says Denise. Based on the genetic testing, the painful endocrinologists would ultimately send a sample of thyroid tissue swallowing, and other complications, such as development of obtained from the FNA to be tested for genetic markers discovered autoimmune thyroiditis, Denise chose to have her entire thyroid and pioneered by Yuri Nikiforov, MD, PhD, director, Thyroid surgically removed. Molecular Diagnostics, UPMC and University of Pittsburgh Cancer After surgery, the RAS-positive nodule in Denise’s thyroid tested Institute (UPCI). The results would make Denise a poster child for positive for a papillary microcarcinoma, which, if left untreated, Dr. Nikiforov’s work. could have spread throughout the nodule and thyroid. Endocrinologists and their patients typically rely on FNA as a Like every surgery, the procedure had risks. As a skilled soprano in method of diagnosing thyroid cancer. Endocrinologists extract her church choir, Denise was told that surgery could change her thyroid tissue from a patient and submit it to a pathology laboratory voice or worse — she might never sing again. “It was a major where it is examined under a microscope to determine if the tissue mental hurdle I had to overcome,” says Denise. “There were a lot of contains malignant or benign cells. According to Steven P. Hodak, risks involved, but Dr. Carty’s skilled hands prevented that.” MD, co-director, Multidisciplinary Thyroid Center, UPMC and Once Denise healed, she found she was able to sing again in her UPCI, and Denise’s endocrinologist, FNA can be falsely negative in church choir. “I waited a few weeks after the surgery even to try, but up to 2 percent of cases. “Even though repeated FNAs can reduce I do have my voice and I’m thankful,” says Denise. the risk of false negative testing, it can’t be eliminated completely,” says Dr. Hodak. Denise takes medication to regulate the hormones that would naturally be produced by her thyroid. “I feel very lucky,” says Denise . Denise’s biopsy tested positive for a mutation in a thyroid signaling “Because of the genetic test and the skilled hands of my surgeon, protein called RAS. “Patients with an RAS mutation have an my thyroid cancer was caught early; it saved my life.” increased risk for thyroid cancer or may already have a hidden thyroid cancer that can be missed on FNA,” says Dr. Hodak. “The “Because of this genetic testing, we were able to intervene at an mutation of Denise’s RAS gene suggested a cancer could be early stage, long before Denise’s cancer became widespread,” says forming in her thyroid.” Dr. Hodak. “That’s the power of this mutational testing.” As a patient of UPMC’s Multidisciplinary Thyroid Center, Denise had the benefit of cross collaboration between key physicians that Denise Murphy’s treatment and results may not be representative of all similar cases.

UPMC Cancer Centers 7 S P I H S N G O N I I T D

A to L L I FIGHT E U R B CANC ER

8 University of Pittsburgh Cancer Institute At her third session of a seven-week radiation treatment plan, breast cancer survivor Patricia Taylor, 64, looked her radiation oncologist in the eye and said, “Whatever happens to me, I want to tell you that in my heart I know you’re giving me your very best. Whatever the outcome, I know you care about me, not just as a patient, but as a person, and that matters to me; it matters a lot.”

UPMC Cancer Centers 9 hat mattered to Patricia in Powerful Partnerships Enhance the Investigating the Physician-Patient those crucial days and Circle of Care Relationship weeks is what matters to all In cancer treatment, when lives are Patient-preference studies have typically W cancer patients every single on the line, patient-centered care is looked at patient relationships with day: confidence in their doctors. about partnership. UPMC Cancer their primary care physicians and Patients and physicians agree that Centers and the University of medical oncologists. Until recently, clinical outcomes may be improved by Pittsburgh Cancer Institute (UPCI) however, few studies have examined a strong patient-physician relationship. foster partnerships that extend among the vital relationship between patients Studies have shown that patients are members of the entire health care and their radiation oncologists. more likely to comply with their team, patients, and their families. Cancer patients often can feel physicians’ recommendations if they Effective treatment is founded on overwhelmed and burdened by the feel comfortable with and cared partnerships between patients and psychological impact of dealing with about by their doctors, and have good doctors, researchers and donors, a life-threatening cancer diagnosis. communication with them. laboratory and clinical researchers, Solid, positive relationships between and between the cancer institute and patients and their radiation oncologists community advocates. can therefore build confidence and “It is a theme we return to again and engage the patients’ full participation again,” says Nancy E. Davidson, MD, in achieving positive outcomes. director, UPCI and UPMC Cancer When Patricia was diagnosed with Centers. “All of these partnerships are breast cancer on Christmas Eve 2008, essential to our continued success in she knew she “wanted to be treated by the fight against cancer.” the best.” A year earlier, her husband, James, 71, was diagnosed with prostate cancer, and while researching the field of radiation oncology in Pittsburgh, her search led her to Dwight E. Heron ,

S MD, FACRO, director of Radiation Oncology Services, UPMC Cancer P Centers. “The word on the grapevine I was that he knew his stuff, that he had

H heart and treated people as individuals.” S N G O N I I T D

A to L L I FIGHT E U R B CANC ER

10 University of Pittsburgh Cancer Institute Patricia had indeed found the right man to treat her husband’s cancer, as well as her own. Dr. Heron was an investigator in a study of the relationship between patients and radiation oncologists. Beginning in 2006, this ground-breaking study, Led by Dr. Bhatnagar as principal UPMC Cancer Centers and UPCI funded by the American Society of investigator, the study surveyed a total physicians and researchers are at the Radiation Oncology and UPMC of 508 patients with breast, lung, or forefront of innovative cancer treatment Cancer Centers, took a systematic prostate cancer who received radiation and research that impacts patient- approach to examining this unique therapy. Patricia was among them. centered care. Now, thanks to the patient-physician relationship. The survey focused on interaction and research of Drs. Bhatnagar and Heron, communication, such as the use of as well as other investigators in the “The radiation oncologist is uniquely everyday language, as well as physical study, and thanks to patients like positioned to develop strong bonds and emotional behavior, such as a Patricia who participated in the with patients by virtue of daily radiation physician’s touch. study, physicians are gaining a deeper treatments that continue for six to eight understanding of how the strength of “The ability of the physician to weeks,” says Ajay Bhatnagar, MD, MBA , the patient-physician relationship can communicate clearly and comfortably adjunct professor, Radiation Oncology influence positive clinical outcomes. Services, UPMC Cancer Centers. with the patient is a critical part of treatment,” says Dr. Heron. These patients’ treatment and results may not be “Both patient and physician benefit representative of all similar cases. through the trust established during On her third day of treatment, when these complex treatment regimens.” Patricia expressed her feelings so openly with Dr. Heron, she remembers he was holding her hand. “He always spoke right to me, eye to eye, never at me or around me,” she recalls. “He gave me faith and he gave me confidence.” A year after her radiation treatments, Patricia is cancer free.

UPMC Cancer Centers 11 Remembering Jeffrey E. Shogan, MD

12 University of Pittsburgh Cancer Institute Chiang Mai

or Jeffrey E. Shogan, MD, Dr. Shogan was a brilliant medical Khon Kaen caring for others came naturally , oncologist who helped to grow the stem Dr. Shogan’s wife Nakong Sawan and it was this caring nature cell transplantation program at Allegheny and children plan Thailand that allowed him to become a General Hospital before joining to carry on his BANGKOK Fwell-liked and highly successful medical UPMC; he also was an integral part of vision to open the oncologist. But even as a businessman, the development and growth of UPMC clinic in Thailand. his caring nature was evident as he Cancer Centers. It was his vision and played a leading role in establishing resolve that led to the inception and

Surat UPMC Cancer Centers in several expansion of one of the largest cancer Thani underserved communities throughout care networks in the country. His efforts

western Pennsylvania and abroad. In also were fundamental in the international Pattani one of his most recent ventures, he expansion of UPMC Cancer Centers, sought to establish a medical clinic in where he helped to set up two centers in Thailand, a project that, unfortunately, Ireland, and was in the planning stages he never had the opportunity to finish. for centers in the United Kingdom , Cyprus, and Turkey. Dr. Shogan, director of business services and chief business officer of UPMC Through the years, Dr. Shogan touched Cancer Centers, passed away in January the lives of many people, including his 2010 at age 56. patients. He was admired by colleagues for his remarkable rapport with patients. “Jeff was an extraordinary individual,” When his patients learned of his untimely says Stanley Marks, MD, director of During his time in the Peace Corps, passing, they likened his death to that of clinical services and chief medical officer , he became passionate about the Thai losing a friend or family member. UPMC Cancer Centers. “He was an people and their culture. Over the past equally skilled oncology physician, A Pittsburgh native, Dr. Shogan grew few years he found time to go back and up in Monroeville, Pa. After completing volunteer, working with children at a “His blend of his bachelor’s degree at Yale University, Thai orphanage. And most recently, he had begun the process of planning and physician skills, he served two years in the Peace Corps stationed in Thailand, followed by a year funding a charitable medical clinic for business acumen, in Nigeria working with Westinghouse, Thai refugees. before attending medical school at the and compassion for “Jeff felt very strongly about bringing University of Pittsburgh. people was unique.” better health care to third-world

Stanley Marks, MD Dr. Shogan’s humanitarian efforts countries like Thailand,” Dr. Marks extended well beyond his years in the says. “To that end, we are working Peace Corps. He established scholarship diligently to make that dream a reality. businessman, and humanitarian. He funds for local students with financial That spoke volumes about him. No had an ability to see an opportunity burdens, often purchased text books matter how tough or politically difficult for change that the rest of us couldn’t. for nursing and medical students in a challenge was, he was always up to His blend of physician skills, business third-world countries, and helped the the task. We will miss him greatly.” acumen, and compassion for people small country of Bhutan with its health was unique. We were fortunate at the Dr. Shogan will long be remembered care needs. Cancer Centers to have benefited from for the legacy he left on the local health his visionary approach to providing care community and abroad. oncology services.”

UPMC Cancer Centers 13 Charitystarts at home

14 University of Pittsburgh Cancer Institute Ph ilanthr opic Efforts T ranslate to Bet ter Care f or Cancer Patie nts

Since its inception in 1985, the University of Pittsburgh Cancer Institute (UPCI) has made exemplary strides in detecting, treating, and eliminating cancer. As the best and brightest in their field, our physicians and researchers have demonstrated an ongoing commitment to advancing UPCI’s mission through their pioneering clinical and scientific efforts. This commitment does not end at the bedside or the research lab.

otivated by personal experiences, inspired Adam M. Brufsky, MD, PhD, co-director, Magee-Womens by patient progress, and encouraged by the Breast Cancer Program, and members of his family, established selflessness of other donors, a strong core of the Ruth C. Brufsky Fund for Clinical Research on Pancreatic M our physicians and researchers has demonstrated Cancer in honor of his mother, who died of the disease. additional dedication as Circle of Hope members in support of UPCI’s research and UPMC Cancer Centers’ patient care “This fund provides seed money for things that might otherwise programs. This special link among our physicians, researchers, not be funded, such as clinical speakers and research,” says patients, caregivers, and donors has helped to foster amazing Dr. Brufsky. “Although the fund is in its infancy, it is beginning to successes throughout UPCI’s 25-year history. make a difference. Already we have sponsored the Ruth C. Brufsky Memorial Lecture and have provided funds for clinical trials.” “I am honored to be leading an organization where our physicians, researchers, and staff have such a level of commitment Stanley M. Marks, MD, director, clinical services and chief to our mission,” says Nancy E. Davidson, MD, director, UPCI medical officer, UPMC Cancer Centers, also understands and UPMC Cancer Centers, and donor. “Our physicians and firsthand how consistent, annual philanthropic support can researchers are making the ultimate commitment: Not only are augment the impact of providing exceptional cancer care. they giving of themselves through patient care and research, He has experienced this through the growth of the Stanley M. they are making a sustainable investment that will ensure the Marks, MD, Endowed Research Fund, established by grateful growth of our cancer programs well into the future.” patients and colleagues to honor the outstanding level of patient care Dr. Marks works to uphold, while contributing to valuable Getting Personal research that will influence the quality of future care. “By donating All donations make an impact, whether they fund a specific to these endowments, we are able to work toward a goal of program or provide support for the organization’s highest priority improving treatments and outcomes. These research dollars needs, such as basic research programs, clinical research, patient are vital to finding new and better treatments,” says Dr. Marks. care programs, recruitment of new physicians and scientists, patient education, and outreach programs. Similarly, the Sampson Family Endowed Chair in Thoracic Surgical Oncology, a permanent endowment established by a One of the channels through which UPMC Cancer Centers grateful patient, family, and friends in 2005, is designed to and UPCI physicians and researchers give back is by creating support outstanding leadership within the Lung and Thoracic endowment funds at UPCI. These funds play an essential role Malignancies Program at UPCI and the Department of in supporting and helping to advance the mission of UPMC Cardiothoracic Surgery. James Luketich, MD, was honored with Cancer Centers and UPCI . They are permanent legacies that the chair after treating Myles D. Sampson, who was diagnosed provide significant recognition, as well as vital annual income. with esophageal cancer. “These endowments help to find new

UPMC Cancer Centers 15 ways of diagnosing and treating cancer,” says Dr. Luketich, who Similar to the Patient Assistance Fund, the OHA Endowed also has supported the chair. “I’m honored to be a part of this Patient Assistance Fund was initiated by Oncology Hematology effort, and I look forward to seeing the advances in detection Associates (OHA), an affiliated oncology group of UPMC Cancer and treatment options it will provide.” Centers. After watching many of their patients struggle financially, the group wanted to make a philanthropic difference by establishing “We as doctors have to set a fund and donating to help financially-challenged cancer patients . The fund was established as an endowment in order to last into an example and show where perpetuity to ensure that help will be available for patients in need. our hearts are.”

Blair Jobe, MD “Donating to the fund is a way to return our good fortune to the community,” says Patrick Kane, MD, a cancer physician in UPMC Cancer Centers’ network and a supporter of the OHA Recently recruited to UPMC Cancer Centers and UPCI by Endowed Patient Assistance Fund. “Many of our patients have Dr. Luketich, Blair Jobe, MD, recognizes and supports the been affected by the economic downturn, and donating to this philanthropic cycle necessary to sustain and advance programs. fund allows us to see immediate results and help people right now.” For example, while grateful patients and families provide support for research efforts he leads, Dr. Jobe chooses to honor those Another key supporter of the OHA Endowed Patient Assistance who support his efforts by joining them as a philanthropic partner . Fund, Kiran Rajasenan, MD, an oncologist in UPMC Cancer Dr. Jobe works with, and donates personally to the Michael J. Centers’ network, supports the fund as a way of giving back to Newton Esophageal Cancer Research Fund, relocated to the the patients who have relied on the OHA practice for excellent University of Pittsburgh, to support esophageal cancer research cancer care. “Contributing to the fund is important to me through the Heart, Lung, and Esophageal Surgery Institute. because it ensures these funds will be used for our own patients,” “We as doctors have to set an example and show where our says Dr. Rajasenan. “It helps provide financial assistance to our hearts are,” says Dr. Jobe. “If we are going to ask others to patients in need, thereby allowing them to focus their energy donate to our causes, then we need to be willing to donate also.” on their health issues.” Recognizing a Need Bridging Science and the Clinic Some physicians want to make a more immediate impact on To improve patient care, UPCI’s philanthropy cycle is deeply the lives of their patients who are affected by cancer. Physicians, rooted in translational research. Among our talented researchers, researchers, and staff across the network have chosen to put Theresa L. Whiteside, PhD, director emerita, Immunologic their charitable dollars toward UPMC Cancer Centers’ Patient Monitoring and Cellular Products Laboratory, UPCI, knows Assistance Fund, created to help cancer patients across the the demands, requirements, and labor necessary to be successful network overcome some of the financial barriers associated with in translating lab discoveries into practical applications at the completing their treatment. The fund is designed to provide bedside. Her research lab evaluates human immune cells’ responses partial, short-term assistance to help eligible patients and their to tumor cells and is working to discover how to reverse the families with care-related costs, primarily nutritional support. effect cancer cells have on a human’s immune cells. Dr. Whiteside generously and consistently supports translational efforts in Barry C. Lembersky, MD, clinical associate professor of medicine immune therapy. “Philanthropy can provide a necessary bridge and contributor to the fund, sees the Patient Assistance Fund as a for accomplishing translation effectively, and relatively rapidly,” way to help patients meet basic everyday needs to live life beyond says Dr. Whiteside. “I want to see the findings made in our the scope of their treatments. “Having cancer and getting the laboratories applied to therapy, so that patients can benefit from correct treatment can be expensive, even for patients with novel discoveries as soon as possible.” excellent health insurance. There are almost always considerable out-of-pocket expenses. By providing patients with temporary financial relief, we can help patients concentrate on getting well; without it, many patients would not be able to complete their treatment,” says Dr. Lembersky. Since its inception in 2005, nearly 1,300 patients in need at 20 different UPMC Cancer Centers have benefited from the Patient Assistance Fund.

16 University of Pittsburgh Cancer Institute As a clinician, Peter Ellis, MD, believes that his direct care with new ways to protect all of us from cancer. I will continue my patients is strongly influenced by the efforts conducted in UPCI’s contributions because of the importance of the work being done research labs. “I am able to do everything I do because of the and the caliber of the people involved.” Dr. Stefanik supports research that was done by those before me,” says Dr. Ellis. Drs. Yu and Epperly’s research in targeting cells that contribute “That’s why I have chosen to help support the researchers who to the growth of tumors. are advancing cancer care.” Contributing Toward the Future Similarly, David Stefanik, MD, a cancer physician in UPMC With each donation, UPMC Cancer Centers and UPCI Cancer Centers’ network, believes strongly in the work being physicians and researchers are working to build the future of performed in his colleagues’ laboratories and supports their the organization from within. “The dedication and selflessness efforts through philanthropic donations. “I contribute to UPCI of our physicians, researchers, and all our donors is remarkable,” to support the work of Grace Yu, PhD, and Michael Epperly, says Dr. Davidson. “Each donation, no matter the size or the PhD,” says Dr. Stefanik. “They work hard at the task of seeking recipient, helps to reinforce the vision for our future.”

A Famil y’s P hi lanthropic Efforts A dvocate for Awareness

As a retired cancer specialist, Jack Hill, MD, has seen many ourselves , but we didn’t want to be victims. We wanted something patients diagnosed with cancer — he just never expected his own positive to come from Suzanne’s death,” says Mrs. Hill. daughter to be one of them. When Suzanne Hill Alfano developed Not only do they support the cause financially, but Dr. and Mrs. Hill a nagging cough and discovered a nodule over her clavicle several also have spent countless hours advocating for awareness that weeks later, Dr. Hill recognized the seriousness of the symptoms. lung cancer is not just a smoker’s disease. According to Mrs. Hill, non-smokers, particularly young women, now make up 15 to 20 percent of lung cancer patients. “My daughter never smoked a day in her life,” says Mrs. Hill. “We are trying to get the word out that you don’t have to be a smoker to develop lung cancer.”

As part of these efforts, Dr. Hill travels around the country speaking to groups about lung cancer, and has even lobbied the Pennsylvania Legislature to provide more money for cancer research. “If we, as surviving family members don’t step up, there will be no one to carry the banner for those lost to this disease,” says Dr. Hill. “That is why we have chosen to take up this cause Dr. and Mrs. Hill with their daughter, Suzanne, and her daughters, and we encourage others to also.” Victoria and Katherine. Thirteen months later, Mrs. Alfano succumbed to lung cancer, “Jack is actively involved because he wants to help raise money leaving behind two daughters , ages 7 and 3, and parents who to fund research,” says Mrs. Hill. “I am involved because I am so decided to dedicate themselves to increasing awareness about angry that something like cancer took my daughter. I don’t want lung cancer. anyone else to have to go through the pain and trauma Suzanne and her young family went through.” In memory of their daughter, Dr. Hill and his wife, Peggy, set up the Suzanne Hill Alfano Endowment for Lung Cancer Research At UPMC Cancer Centers and UPCI, the combination of personal at the University of Pittsburgh Cancer Institute (UPCI) to support commitment, such as that embodied by Dr. and Mrs. Hill, and lung cancer research and awareness. They hope their long-term philanthropy has a powerful effect on the quality of care offered, commitment to UPCI will not only honor their daughter, but also not only to patients but to the field of cancer medicine, as well. contribute to finding a cure. “We could lie down and feel sorry for

UPMC Cancer Centers 17 Philanthropy has many forms — donations, sponsorships, Pittsburgh Cancer Institute (UPCI), your continued support underwriting, community-based events, planned giving, in-kind ensures that we can continue to unravel the mysteries of cancer. support, and volunteerism — each one as important as the next. And every time we do, we move another step closer to improving the lives of all cancer patients and survivors. No use of resources yields a better return than the collective impact of your generosity on our patients and their families. From all of us at UPMC Cancer Centers and UPCI, thank you for When one person is diagnosed with cancer, a vast network of your ongoing partnership in all of our philanthropic efforts and, people connected to that individual weathers the effects of the above all, for sharing our commitment to a future without cancer. disease. At UPMC Cancer Centers and the University of

ENDOWED CHAIRS DSF Charitable Foundation Ruth C. Brufsky Fund for Clinical Research on A number of endowed chairs support the mission of UPMC Flight Attendant Medical Research Institute Pancreatic Cancer Cancer Centers and the University of Pittsburgh Cancer The Giant Eagle Foundation Patti Burns Fund Institute. The income generated from endowed chairs enables Theresa Heinz and The Heinz Endowments Al Copeland Memorial Fund for Merkel Cell our scientists, clinicians, and their teams to strengthen Harriett L. and Ronald B. Herberman, MD Carcinoma Research established areas of expertise, expand new initiatives, and Highmark Foundation Dr. Joan G. Gaines Breast Cancer Research Fund forge new frontiers in science that benefit our patients Elsie H. and Henry L. Hillman Sadie Gerson Distinguished Visiting Scholar Program and their families now and into the future. Henry L. Hillman Foundation Stuart Goodman Brain Cancer Memorial Fund Hillman Foundation Peter E. Hackney Fund for Pancreatic Cancer Research The Claude Worthington Benedum Endowed Chair in Family and Friends of Albert P. Knowles* Harvey G. Herberman, MD Memorial Cancer Radiation Oncology New Era Cap Charitable Foundation and Research Fund The Jane and Carl Citron Endowed Chair Family and Friends of David C. Koch* Dr. George W. Hiett Foundation Fund in Colon Cancer Mario Lemieux Foundation Dr. Herbert E. Jacob Memorial Fund The Richard M. Cyert Endowed Chair The Leukemia and Lymphoma Society Hyman I. Katz Cancer Research Fund in Molecular Oncology Richard King Mellon Foundation Barbara Klump Memorial Scholarship Fund The Gregory T.H. Davies Endowed Chair in Brain Susan G. Komen Breast Cancer Foundation Frank W. Knisley Memorial Fund Tumor Research and Physician Education N.S.A.B.P. Foundation, Inc. Albert P. Knowles Research Fund The Lawrence Ellis Endowed Chair in Arnold D. Palmer 2003 Charitable Trust David C. Koch Memorial Fund Hematology and Oncology Mark E. Pasquerilla Mario Lemieux Patient Care and Cancer Research Fund The Bernard Fisher Endowed Chair in Surgical Oncology PNC Financial Services Group and PNC Foundation Scott Limbach Entrepreneurial Center The Giant Eagle Foundation Endowed Chair The Pittsburgh Foundation Stanley M. Marks, MD Endowed Research Fund in Cancer Genetics Myles D. Sampson* and Family The Liliana Muhlmann Masoner Cancer Fund The Hillman Endowed Chair in Oncology Sanofi-Aventis Drew Mathieson Entrepreneurship Fund The Arnold Palmer Endowed Chair in Cancer Prevention The David S. and Karen A. Shapira Foundation James A. Mollica Jr. Research Endowment Fund The Sampson Family Endowed Chair in Thoracic Sandra and Thomas Usher OHA Endowed Patient Assistance Fund Surgical Oncology Debi and Harold W. Wheeler III PNC Innovation Fund The Sandra and Thomas Usher Endowed Chair Wheeler Family Charitable Trust Michael J. Parada Research Fund in Melanoma * deceased Parada Family Liposarcoma Research Fund UPMC Endowed Chair in Head and Neck Cancer Mark E. and Leah M. Pasquerilla Women’s Cancer Surgical Research FAMILY LEGACY SOCIETY Research Fund UPMC Endowed Chair in Lung Cancer Research Often, a personal experience with cancer or the loss of a loved Pasquerilla Cancer Genomics and Proteomics one to the disease spurs a family or others to establish funds that Research Fund VISIONARY SOCIETY honor a patient or caregiver through support of continuing Linda Saulle Endowed Memorial Fund These dedicated partners have given or helped to raise a efforts to better detect, prevent, and treat cancer. Frieda G. and Saul F. Shapira BRCA Cancer cumulative total of $1 million or more in support of cancer Research Program research and care. Suzanne Hill Alfano Endowment for Lung Cancer Research The Spang Translational Research Core Facility Nathan S. Arenson Fund for Pancreatic Cancer Research Joseph and Giovanna Tarquinio Memorial Fund American Cancer Society, Inc. Adriane R. Aul Memorial Fund Edward Thaw Blood Research Fund Anonymous Beckwith Family Foundation Endowed Research Edward Underhill Memorial Fund for Colon Family and Friends of Nathan S. Arenson* Scholars Program Cancer Research Claude Worthington Benedum Foundation The Heidi Browning Endowed Ovarian Cancer Research Wayne Fusaro Pancreatic Cancer Research Fund Scholars Fund Dr. Leonard S. Zombek Memorial Fund

18 University of Pittsburgh Cancer Institute PLANNED GIVING Jamini Vincent Davies The Michael J. Newton Esophageal Cancer Foundation UPMC Cancer Centers and the University of Pittsburgh Burtis J. Dolan Family Vance K. Opperman Cancer Institute gratefully acknowledge planned gifts from the Ann and Edward Dunlap Saundra and Gene O’Sullivan following individuals : Mary Lou and Richard Durr Kit and Arnold D. Palmer Lori and Peter Ellis, MD Leah M. Pasquerilla Cheryl and Bruce Americus William F. Fabrizio Lisa and Mark E. Pasquerilla Mr. and Mrs. Donald E. Chrise Diane Faust and Barry Lembersky, MD Kathleen and Demetrios Patrinos Susan and Barney Guttman Sheila and Milton Fine Jai Pausch — in memory of Randy Pausch Harriett L. and Ronald B. Herberman, MD Stephanie and Thomas Flannery Donald Plung* Margaret M. and John B. Hill, MD Kimberly and Curtis Fleming Hilary Tyson and Charles Porter Betty Lou Luketich Robert Flug Dorothy L. and Richard E.* Raizman, MD Anna Piocquidio Foster Charitable Foundation at the recommendation of Rosemarie and Kiran Rajasenan, MD Hilda M. and Henry D. Sundermann Jr. Issie and Lee Foster, Barbara and Bernard Mars, Wendy David Rath Bonnie W. and Thomas L. VanKirk, Esq. Mars, PhD, and Peter Mars Diana and Frank Rath Debi and Harold W. Wheeler, III Jane K. France and Christian L. Allison Lillian S. Rath ______Murry Gerber Kristy and William Rodriguez ANNUAL GIVING Merle E. and Olive Lee Gilliand Foundation Roesch Family Foundation The Annual Fund provides vital support for the operation of Thomas B. Grealish Stefania and Jeffrey Romoff clinical programs, basic and clinical research programs, Rhonda and Glen Gross Cynthia Roth and James Kunkel, MD recruitment of new physicians and scientists, seed money Sara and Alan Guttman Diane and Cliff Rowe, Jr support, medical and patient education, and outreach programs. Susan G. and Barney C. Guttman Abby and Reid Ruttenberg Those listed have made sustained annual investments at the Hawksglen Foundation Kim and Ben Sampson following designated levels. Teresa Heinz and The Heinz Endowments Athena and Frank* Sarris ______Heidi and Robert E. Heltzel Ritchie Scaife Harriett L. and Ronald B. Herberman, MD Mikell and A. William Schenck, III CIRCLE OF HOPE Margaret M. and John B. Hill, MD Tracy and Evan J. Segal The Circle of Hope honors individuals, family foundations, Elsie H. and Henry L. Hillman Shandle Foundation and privately held companies that make contributions of The William Talbott Hillman Foundation Cindy and David S. Shapira $10,000 or more in a calendar year. This list recognizes Joan and Daniel Hilson Deborah Shapira and Barry Stern, PhD those who were members in 2008, 2009, and through 2010 Cathy and Sy Holzer Edith Shapira, MD and Mark Schmidhofer, MD to this point of publication . Elizabeth and Blair A. Jobe, MD Barbara and Herbert Shear Janis and Jonas Johnson, MD Shirlie and Owen Siegel Foundation Anonymous (5) Sharon and Richard Juve Gayle and William Simpson The Joseph Allen Foundation Becky Burgwin and Patrick L. Kane, MD Sharon and Bob Slagle Cheryl and Bruce Americus Linda and Frank Kass Sandy and Edgar Snyder Patrice and Robert Americus Tricia and William Kassling Patricia G. Snyder Ayers Foundation Karen and Joseph L. Kelley III, MD Rebecca C. Snyder Debbie and Michael Barbarita Kathryn and Cary Klein Patricia and William Snyder Beckwith Family Foundation at the recommendation of Koch Family Paulette and David F. Stefanik, MD Dotty and Nick Beckwith and Alice and Jim* Beckwith Valerie R. Koch Rachel and Scot Stevens William F. Benter Curtis I. Kossman Foundation Stork Foundation Jack L. Bergstein — in memory of wife, Fyrne Bergstein Perlow Family Marcia and Perry Swanson Ken Bernstein and Jacquelyn Soffer Nathalie and Mario Lemieux Pamela and Markos Tambakeras Renard L. Biltgen Robert Levin The Tippins Foundation Irene Blumenkranz and David E. Gold Sally Levin Gayle L. Tissue and Yiannis Kaloyeropoulos Mary Ann and Charles Bogosta Anne Lewis Bonnie W. and Thomas L VanKirk, Esq. Barbara and Gary K. Bowser Sr. Christine and James D. Luketich, MD James F. Walsh Foundation Susan and Michael Boyle Anna and John Maaghul Marilyn and Norman Weizenbaum Lisa and John L.B.* Brooke The Seena Magowitz Foundation Wheeler Family Charitable Trust Jill Brufsky and Adam Brufsky, MD, PhD Reena and Baljeet Mahal, MD Debi and Harold W. Wheeler III Seth Brufsky David J. Malone Priscilla and Joseph Whiteside Bernita Buncher Stanley M. Marks, MD Theresa L. Whiteside, PhD Barbara and Gerald E. Chait Mars Family Charitable Foundation Robin and Gary Zentner Susan and Alan Citron (Mr. and Mrs. Bernard Mars) * deceased Carl Citron Shirley Hobbs Martin Memorial Fund Mary and Jay Cleveland Jr. Myrna and Mark Mason LEADERSHIP CIRCLE Sandra S. and Richard A. Cohen Susan and Stephen McGalla ($5,000 - $9,999) The Al Copeland Foundation Fran and Jim McGlothlin Robert Dennis Caryn and Sam Covelli Linda and David McKamish David Duncan J. Samuel and Rose Y. Cox Foundation Katie and David McSorley Emilio A. Fernandez Barbara Ann and Robert A. Crown Moody and Associates, Inc. Robert Joel Gluckman, MD Randi and L. Van V. Dauler Jr. Jane and Edward Moravitz Sandra and Lee Goodman Sandra N. Danoff Donald A. Mosites Mary Jane and Carl G. Grefenstette Nancy E. Davidson, MD and Thomas Kensler, PhD

UPMC Cancer Centers 19 Dwight E. Heron, MD David E. Malehorn Mr. and Mrs. Kevin M. Corcoran Susan W. and Michael W. D. Howell Marsha D. Marcus, PhD and Bernard D. Marcus Justin Crum A. Richard Kacin Susan and Geraldo J. Matos Armand C. Dellovade Richard P. Krieger Raymond J. Mauro Gary Dille United Jewish Federation through the Anne and William O. McConnel Susan B. and The Honorable Michael F. Doyle Lester A. Hamburg Endowment Fund at the Francis E. McHugh Pamela Abbott Eisner recommendation of Farrell Rubenstein Michael Medress Edward J. Flammer Sheryl Simon, MD Ray Mekis Christy Fleming Jay Vetere Scott A. Molander Marne B. and Peter B. Geller, DDS Darell Myers Beth R. Grabiak, PhD PARTNERS FOR PROGRESS Carolyn N. Pfefferle James R. Grundtisch ($1,000 - $4,999) Dr. and Mrs. Julian W. Proctor Elisa D. Harris Amada and Rashid A. Awan, MD Hariklia and Anastasios Raptis, MD, PhD Lathe Haynes, PhD Elinor M. Abplanalp Robert W. Riordan Audrey Hillman Hilliard William J. Adams Jean A. and Frank Brooks Robinson Samuel Lawrence Huey Nicholas James Alfano Sylvia and Donald M. Robinson Sarah H. and Lewis K. Johnson Kimberly and Peter M. Augustine James P. Rosenbloom Timothy L. Kane Eugene Bang Nancy Rozendal Thomas A. Labert Kathryn A. Barbustiak Richard J. Saab, MD William B. Larkin Susan J. and David L. Bartlett, MD Salvatore J. Savarino Mark Levin Denise and Raymond L. Barry Jr. Gregg Searle Barry Levine Earl M. Benovitz Mary Kay Sedlacek Claire and Lawrence Levine Samuel Wayne Braver Tracy Robin Seewald, MD and Steven A. Burton, MD Elsie Y. Lewis Sheryl and Jeffrey S. Broadhurst Katherine A. Servich Mignon and Waldemar J. Love William O. Brown Pat and Theodore N. Shaffer Gary R. Luchini Janet Bryant Timothy Sherry Don F. Manns J. Glenn Campbell Mary and Richard Skubak Helen B. and Curtis R. Marquard Margaretha L. Casselbrant, MD Sally M. Snyder and Lee F. Snyder Jacqueline and David Martin Barbara Wheeler Davies and Randy Arlen Davies Jeffrey Wayne Spear, Esq. Kriston and Robert J. McMichael Jr. Malindi Davies Valerie J. Stabile John L. Mehltretter John J. DeWaal Michael D. Voloshin, MD Eliza and Hugh Nevin Jr. Cathleen and Anthony M. DiGioia III, MD Suzanne and Richard L. Wagner Thomas J. Osborn Douglas W. Dimitroff, Esq. Lisa and Peter J. Walsh James S. Pasman Jr. Laura E. and Alfred P. Doyle, MD Preston G. Walsh Susan H. and John Alden Redfield, PhD Sally H. Durrant, Esq.*, and Robert E. Durrant, Esq. Naomi and Peter B. Waltman Carol J. and Patrick R. Riley Lowrie C. Ebbert Erika and Mike Wargula Sally S. and Fred M. Rock Ralph A. Falbo Jr. H. Bryan Werner Ann A. Rogers Donald L. Faust Sr. Paul G. Wessel Alan Rosskamm Mr. and Mrs. Thomas P. Frizzell * deceased Frances Bartosiewicz Saxon & George E. Saxon Sr. Donna L. Gerson and David A. Gerson Doris M. Scott K. A. Gieraltowski CHAMPIONS Bonnie Seaton Maryedna Gillespie-Gennaula ($500 - $999) Darcy L. Sefer Lee and J. Roger Glunt Nicholas E. Andrews Jan D. Smith, MD Carlotta M. Goetz John W. Anthony Kenneth James Spangler Jennifer Grandis, MD and Donald J. Grandis, MD Yoshio Arai Ruth A. Sturtz Stacy Granger Lynne and Roger L. Barna David P. Swanson Nancy Hamilton David P. Bartels, OD Sara B. Thompson Sarah J. and C. Talbot Heppenstall Jr. Nancy Bernstein and Robert E. Schoen, MD, MPH The Honorable Leo J. Trich Jr. Mary Jo and Thomas M. Hill George M. Blair Margot L. Watt and Sebastian W. Fasanello James G. Hopkins Nadine E. Bognar Roy H. Waugaman Jean and Samuel A. Jacobs, MD Bernice Hilberg Bollman and Philip D. Bollman Jr. Catherine and Jason Webber LaVonne and Glen R. Johnson David E. Brougher, MD Diane and Jonathan Webber Amy and Dennis J. Kelleher Charles Kuang Ming Brown, MD, PhD West Herr Automotive Group, Inc. James E. Kelly, Esq. John C. Brown Janet M. Williams Steven M. Kinney Michael D. Cashatt Samuel C. Williamson Emily A. and Herman F. Kroboth James F. Cawley Claudia C. Zavodnick Paul E. Lego Patrick Clancy Wen Zhu, MD and Min Sun, MD Barbara K. LeStage David T. Clark In memory of Elliott (Bud) Lewis from Lewis Family: Gary Clark Harriet, Barbara, Marc, Scott, and Kim Clare Collins and Brian P. Gabriel, Esq. Gordon Lisker Kelli L. and Robert W. Cook Terri and Timothy J. Logan Thomas G. Cooney Sr.

20 University of Pittsburgh Cancer Institute AMBASSADORS Steven W. Maas BUSINESS, CORPORATIONS, ADVOCACY ($250 - $499) David T. Magrish ASSOCIATIONS, AND OTHER GROUPS Frank J. Anesi Dorothy Maritime UPMC Cancer Centers and the University of Pittsburgh Vijay Atri James Matheny Cancer Institute gratefully acknowledge gifts of $250 or Carole Baierl Elizabeth B. Matthew more from businesses, corporations, advocacy associations, Raelene C. Baker John Regis McConaghy, MD and other groups. Linda and Alan K. Berk James Patrick McDonald Jeffrey P. Bissell Francine and David M. McDowell ($100,000 + ) Rachel Kirk Bobo Jeff McFater Metanexus Institute Nancy and David Buck Arnold I. Meisler, MD Nicoline N. Burkhart Alexander M. Neidhardt III, DDS ($50,000 - $99,999) Candace Cain Daniel A. Nestel American Lung Association David W. Calvin Alice Hopkins Newton MedImmune, Inc. David A. Caperelli James S. Patterson Christine Carmazzi Thadeus M. Pawlikowski ($25,000 - $49,999) Barbara Casanova Patricia Pifer Eastern Cooperative Oncology Group Research Paul B. Caton Mildred Posvar Friends for an Earlier Breast Cancer Test Joseph Rodney Chapman Jennifer Raetz Jennifer L. Chestnut John Charles Regan ($10,000 - $24,999) Carol L. Clapp John D. Rhodes Active Media Services, Inc. Connie and Bruce T. Cleevely Betty Sue and Larry Rich Aramark Corporation Gerald Collins Anthony Ricottone, MD Ares Management II, L.P. Michael G. Dehler Norman Robertson The Buncher Company Philomena M. Demeter K. George Schoeppner Friends of Plum Running Mustangs Alumni Association Katherine Munsch DeSimone, Esq. and John A. Scotti P.J. Dick, Trumbull, Lindy David Ralph DeSimone Lois T. and Ross H. Smith Jr., MD Phillips Lytle LLP Frank H. Dettore Marguerite and The Honorable William L. Standish Dennis L. Doutt Christine Stanko ($5,000 - $9,999) Mary Ruth Sampson Eckman Lyndia C. Stauffer American Heart Association Arthur S. Ellis Louis A. Steiner Ladies Hospital Aid Society of Western Pennsylvania Colleen M. Ellis George E. Steins New Era Cap Company, Inc. USA Jeffrey J. Eng Charles J. Stout New York Yankees Thomas Esper Sharon R. Stultz Panera Bread Robert L. Ferris, MD, PhD Jan and Carmen N. Tarasi Radelet McCarthy Polletta, Inc. Charles H. Fletcher Jr. Edward Teeple Jr., MD RSM McGladrey, Incorporated Eve France and Howard M. Maisel Arne van der Heyde Speed Global Services Anthony C. Giunta Jessie M. Van Swearingen, PhD The TJX Companies, Inc. Gregory Grabiak, MD Barbara J. and M. M. Vujevich, MD United Parcel Service Chris Ann Hays Qingde Wang, MD, PhD Workflow One Milford L. Hazlet Janis and Kenneth M. Wasserman, CP Andrew D. Hicks Elizabeth and Robert B.* Weidlein ($1,000 - $4,999) Susan and David H. Hicks Susan E. Weintraub American Coaster Ad-Mat North Mary and Mark E. Hoffman Roger W. Wilson American Society of Hematology Celestin Holmberg Ronald L. Witt BHNT Architects, P.C. Joan M. Holtz Denise DeBartolo York and John C. York, MD Bison Baseball Inc. Jean L. Hort Walter R. Zoladz III Bond, Schoeneck & King, PLLC Julie and Daniel Graham Hudak Joseph John Zwirecki Buffalo Neurosurgery Group Richard A. Hundley * deceased CF Brand, LLC Sally E. and Peter Kay Colgate-Palmolive Company Joseph Michael Klaja ESTATES AND TRUSTS Creative Displays & Packaging, Inc. Rebecca Lahniche UPMC Cancer Centers and the University of Pittsburgh Curbell Plastics Inc. Harold S. Larrick Cancer Institute gratefully acknowledge gifts from the following Delaware North Companies, Inc. Patricia and Thomas C. LeClere individual estates and trusts: Eagle Buckram Co., Inc. Mary M. Lee Empire Financial Partners Marlene Katherine Leech Estate of Robert M. Colteryahn Evans City Elementary and Middle Schools Suzanne Lentzsch, MD, PhD and Estate of John F. Fortney Evans National BankFedEx Trade Networks Markus Y. Mapara, MD, PhD Gertrude E. Hellerman Charitable Trust Fund Friends of Mellie’s Mission Joann J. Lewis Estate of Jane Dee McNamara G & G International, L.L.C. Mary Carol and John F. Lewis Trust for the Benefit of Dr. Michael Markow Genesco Dr. and Mrs. Ronald G. and Judith K. Linaburg Estate of Miriam Renton Richards Gibraltar Industries Diane Lucas Hadley Exhibits, Inc. Betty Lou Luketich Hannan Executive Services Inc.

UPMC Cancer Centers 21 FOUNDATIONS UPMC Cancer Centers and the University of Pittsburgh The 2010 Hillman Cancer Center Gala was held Nov. 30, 2010 Cancer Institute gratefully acknowledge the foundations that at the Monroeville Convention Center. The event, Celebrate! have provided support of $250 or more to further our mission. A Future Without Cancer , commemorated 25 years of UPCI Anonymous Ayers Foundation and once again supported cancer research priorities. For more The Joseph Allen Foundation Beckwith Family Foundation information please contact the UPCI and UPMC Cancer Centers The Breast Cancer Research Foundation Binational Science Foundation Development department at 412-623-4700. BJALCF Foundation The Brain Tumor Society, Incorporated Buffalo Bills Alumni Foundation Inc. Buffalo Sabres Foundation The Buhl Foundation Hattan Concepts, Inc. Ateleta Beneficial Assn. Julius H. Caplan Charity Foundation HealthNow New York Inc. BHS International Grant Channell Memorial Fund Information Technology Department, PPG Industries Carr Textile Corporation The Al Copeland Foundation Jo-Ann Stores, Executive Committee Celgene Corporation J. Samuel and Rose Y. Cox Foundation Kids and a Cause Colleagues at Bayer Material Science Canada Dee Dee Sacco's Fight For Life Fund Lawley Agency Insurance Cook Moving Systems, Inc. The Ellison Medical Foundation LIA Agency, Inc. Doyle for Congress Committee EQT Foundation M &T Bank Eaton Office Supply Co., Inc. The Audrey Hillman Fisher Foundation M &T Insurance Agency, Inc. The Ellis School 9th Grade Class of 2012 The Nina Baldwin Fisher Foundation, Inc. Menasha Corporation Employees of Valier Coal Yard John F. Fortney Charitable Pancreatic Cancer Research Group Menasha Packaging Company, LLC Employees of West Chester Area School District Foster Charitable Foundation Menlo Worldwide Logistics Facility Merchandising Incorporated Wayne Fusaro Pancreatic Cancer Research Fund Milliken & Company Fairmount Partners LP Gabrielle's Angel Foundation for Cancer Research MJ Mechanical Services, Inc. Fidelity Bank Shawn Gaertner Foundation Ogletree, Deakins, Nash, Smoak & Stewart, P.C. Florida Marlins, L.P. Merle E. and Olive Lee Gilliand Foundation P & P Flooring LLC Fox Chapel Presbyterian Church Gist Cancer Research Fund Michael J. Parada Walkathon Friends of Charlie Houser Hawksglen Foundation Pittsburgh Associates Friends of Dave Campbell The Heinz Endowments Saperston Asset Management, Inc. Goya Foods Great Lakes The William Talbott Hillman Foundation Selections by Genea & Eric Greenberg Traurig, LLP Emma Clyde Hodge Memorial Fund SML Group Hewlett-Packard Company Curtis I. Kossman Foundation Speed Motor Express of W.N.Y., Inc. HSBC Bank USA Incorporated The Judith A. Lese Breast Cancer Foundation, Inc St. Andrews Products, Co. In-House Dental Services Elaine and Donald Levinson Foundation Staff of Hillman Cancer Center, James Services Life Raft Group Outpatient Services, 3rd Floor LaBarge, Inc. Lumina Foundation for Education, Inc. Sterling Mets, LP Leedsworld, Inc. dba LEED’s The M & T Charitable Foundation Susquehanna International Group, LLP Magee NICU Nurses The Seena Magowitz Foundation The American Ireland Fund Malizia, Spidi & Fisch, PC Mars Family Charitable Foundation The Hillman Company Merrill Lynch, Pierce, Fenner & Smith, Inc. Merrill Lynch & Co. Foundation, Inc. The Martin Group, LLC Morgan Lewis & Bockius, LLP The Robert Bensen Meyer, Jr. Foundation, Inc. The Philadelphia Phillies Office of the Senior Vice Chancellor for the Health Sciences Multiple Myeloma Research Foundation ThermaSolutions, Inc PharmaWrite, LLC Musella Foundation Transportation Marketing Services International, Inc RP Sales, Inc. National Hockey League Foundation Truist S. M. Cristall Company, Inc. Robert L. Newman Foundation United Business Systems, Inc. San Diego Padres L.P. The Michael J. Newton Esophageal Cancer Foundation UNO Restaurants, LLC. Shindler Sport Sales, Inc. The New York Mets Foundation, Inc. Vautier Communications Singlesource Property Solutions, LLC Elsa U. Pardee Foundation VF Services, Inc. St. James Choir Fund PhRMA Foundation William H. Prentice, Incorporated Staff of Hillman Cancer Center, Outpatient Services, 2nd floor The Pittsburgh Foundation WPH Airport Associates Tiffany & Company The Broadhurst Family Fund Turkey Trot for Prostate Cancer The Callihan Family Fund ($250 - $999) Turner Construction Company The Gertrude E. Hellerman Charitable Trust Fund 84 Lumber Company United Way of Westmoreland County The Charles and Jean Stout Family Fund Accordia Global Compliance Group W. W. Grainger Inc. The Frank E. Rath/Spang and Company Charitable Trust Alliance Bernstein, L Waz Engineering Rauch Foundation Alpha Epsilon Phi Sorority Young Adults Circle The Sampson Foundation Annual Reviews

22 University of Pittsburgh Cancer Institute Roesch Family Foundation Mr. and Mrs. Scot R. Stevens The power of partnership: Shandle Foundation Dr. Kevin J. Stewart Shirlie and Owen Siegel Foundation Patricia and James Terwilliger A future without cancer The Henry John Simonds Foundation, Inc. Sheila M. Trasp The Juliet Lea Hillman Simonds Foundation, Inc. Janet Tripodi On Oct. 6, 2009, 650 of the region’s Charles F. Spang Foundation Randolph E. Van Meter most influential community and civic Stellar Solutions Foundation Robert G. Yurko Stork Foundation leaders and supporters gathered at the The Tippins Foundation UPMC CANCER CENTERS AND new Monroeville Convention Center for THE UNIVERSITY OF PITTSBURGH UB Foundation Activities Inc. the 2009 Hillman Cancer Center Gala to The Frank Varischetti Foundation CANCER INSTITUTE DEVELOPMENT James F. Walsh Foundation DEPARTMENT celebrate more than $3.6 million raised Samuel Emma Winters Foundation Jennifer Raetz, Development Director to advance cancer research and patient Yates Fund for Cancer Hope Kambra McConnel, Major Gifts Officer care programs at Hillman Cancer Center. Rosalyn Markovitz, Major Gifts Officer UNITED WAY Eleanor Flannery, Administrative Coordinator Donors that designated United Way donations and/or pledges The 2009 gala theme, The Power of of $250 or more in support of the UPMC Cancer Centers and Every gift to UPMC Cancer Centers and the University of Partnership, exemplified the key the University of Pittsburgh Cancer Institute agency codes Pittsburgh Cancer Institute plays a vital role in advancing partnerships that together form the core during the 2008 United Way and United eWay Campaigns research and enhancing patient care. Unfortunately, space (June 2008 through April 30, 2009). mission of UPCI and UPMC Cancer is too limited to list the individual names of donors that gave gifts at levels of $1 to $249. Please know your support Centers to provide excellence in patient Kristin R. Bell is truly appreciated. Michael Bell care, education, and research. Mary Ann and Charles Bogosta If we have made any errors in any name or omitted anyone Daniel M. Bonacci Guests were treated to a performance from this list, please accept our apologies and notify us at Jody L. Cervenak 412-623-4700. by Emmy award-winning actress and Sandra N. Danoff ______singer Kristin Chenoweth, a dance Lila I. Decker Robert A. DeMichiei performance by the Pittsburgh Ballet UPMC CANCER CENTERS AND Lori and Peter Ellis, MD THE UNIVERSITY OF PITTSBURGH Theatre School, and dinner prepared by Elizabeth and Alan H. Finegold CANCER INSTITUTE CAPITAL Kimberly and Curtis D. Fleming UPMC executive chef Brad Kelly and his CAMPAIGN COMMITTEE Woodrow W. Frazier III team. Pittsburgh native actor Michael Honorary Campaign Committee Mark S. Georgiadis, MD Keaton served as master of ceremonies Sean M. Girdwood Elsie Hillman Jack S. Goldsmith Valerie Koch for the evening. Debra Graczyk Arnold Palmer Thomas B. Grealish Jim Rohr Gala leadership and supporters included Robert J. Howard Tom Usher honorary chairs Elsie and Henry Hillman Clarissa Johnson Dr. and Mrs. Jonas T. Johnson Campaign Committee and Cathy and Sy Holzer; gala chairs Sean Jay Jones Susan Boyle Susan and Steve McGalla; and presenting Michael Boyle Christopher J. Kairys sponsor PNC. Gina Rose Karafa Richard A. Cohen Julie H. Kuhr Nancy E. Davidson, MD Karen L. Larrimer Thomas Flannery Nancy J. and Stanley Lehman, Esq. Kimberly Fleming Marc D. Marks Thomas B. Grealish Stanley M. Marks, MD Barney C. Guttman Joyce A. Metnick William Kassling Ione and Kenneth Miller Cary Klein Nicholas Molea Jr. Barry Lembersky, MD William R. Newlin James D. Luketich, MD William S. Niznik Jr. Stanley M. Marks, MD David Rajkovich Leslie Merrill McCombs Jeffrey Reis Mark E. Pasquerilla Kimberly Beth Schriver Bonnie W. VanKirk Shenango Incorporated Tom L. VanKirk, Esq. Ellen Sheppard Debi Wheeler Patrick M. Stabile Harold W. Wheeler III Randall J. Staggers Theresa L. Whiteside, PhD

UPMC Cancer Centers 23 briefs NEWS UPCI researcher awarded V Foundation grant The V Foundation for Cancer Research awarded a $1-million grant to Jill M. Siegfried, PhD, co-director of UPCI’s Lung Researchers receive and Thoracic Malignancies Program, to establish two new patent for DNA therapy clinical trials for lung cancer patients at UPMC Cancer In January 2010, the Centers. The first trial, based on Dr. Siegfried’s research, United States Patent and examines estrogen’s role as a lung cancer proliferation Trademark Office awarded agent. The Phase II trial focuses on the use of an aromatase a patent to physician- inhibitor, a class of drugs designed specifically to counteract researchers from the estrogen production. By targeting estrogen, researchers University of Pittsburgh School of Medicine for the development hope to extend the lives of women with lung cancer. of a new DNA therapy for head and neck cancers. Standard Founded in 1993 by ESPN and Jim Valvano, legendary former treatments for head and neck cancers are often ineffective basketball coach of North Carolina State University, the and accompanied by debilitating side effects. The new V Foundation has raised more than $90 million to fund treatment is based on a form of genetic therapy called cancer research nationwide. antisense, or AS, in which a synthesized strand of DNA or RNA targets the epidermal growth factor receptor (EGFR) within head and neck tumors. Expectations were exceeded during the Phase I study, which was designed primarily to determine the safety and potential toxicity of EGFR AS injections. Not only were the AS injections well-tolerated, Milestone in neurosurgery but tumors disappeared or shrank considerably in 29 percent In December 2009, UPMC neurosurgeons performed their of patients. A Phase II study evaluating the safety and 10,000th Gamma Knife® procedure, a milestone surgery efficacy of EGFR AS injections in combination with another that further distinguishes UPMC as a leader in radiosurgery drug is currently underway. experience. Gamma Knife radiosurgery is a multidisciplinary procedure, requiring the expertise of radiation oncologists and medical physicists, who partner with neurosurgeons in the treatment of complex brain tumors. UPMC Cancer Centers is a highly regarded international training and research center, offering instruction to medical experts worldwide. Pittsburgh Steelers team members Gamma Knife, first used in North America in 1987 by a visit Hillman Cancer Center UPMC clinician, destroys brain tumors often considered to Three Pittsburgh Steelers visited patients and families at be inoperable. Gamma Knife Hillman Cancer Center in Shadyside. The team’s center, Justin procedures are noninvasive Hartwig; tight end, Shawn McHugh; and right guard, Trai Essex and use radiation to target signed autographed pictures, posed for pictures, and shared diseased brain tissue, stories with patients. Patients enjoyed the afternoon with the resulting in bloodless brain players and UPMC Cancer Centers and Hillman Cancer Center surgeries that require no appreciated the visit. incisions.

Photo courtesy of the Pittsburgh Steelers

24 University of Pittsburgh Cancer Institute UPMC Cancer Centers and University of Pittsburgh Cancer Institute

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A publication of UPMC Cancer Centers and the University of Pittsburgh Cancer Institute

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UPMC Cancer Centers offers cancer patients exceptional care and innovative treatments close to home. Working in tandem with the University of Pittsburgh Cancer Institute, western Pennsylvania’s only National Cancer Institute- designated Comprehensive Cancer Center, UPMC Cancer Centers provides the latest advances in cancer prevention, detection, diagnosis, and treatment at community-based locations throughout the region. The University of Pittsburgh Cancer Institute comprises the academic and research activities for cancer at the University of Pittsburgh and UPMC.

For information about supporting cancer research efforts and patient care at UPMC Cancer Centers and the University of Pittsburgh Cancer Institute, contact us at 412-623-4700.

UPMC Cancer Centers and University of Pittsburgh Cancer Institute

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