Graduate Interdisciplinary Faculty of Biotechnology

Professional Program in Biotechnology

Biotechnology Program Self-Study

January 2010 ExternalReview Biotechnology Program Self-Study

TABLE OF CONTENTS 1. INTRODUCTION 4 1.1 Welcome 4 1.2 Charge to the Review Team 5

2. TEXAS A&M UNIVERSITY SYSTEM 6 2.1 The University System 6 2.2 Texas A&M University 7

2. GRADUATE INTERDISCIPLINARY PROGRAMS 9 3.1 Origins of the Interdisciplinary Program in Biotechnology 10 3.2 Program Overview 12 3.3 University Administration of the Biotechnology Program 13 3.3.1 IDP Management (2005- late 2008) 13 3.3.2 IDP Management (Late 2008-- Present) 14 3.4 Administrative Structure of the Professional Program in Biotechnology 14 3.4.1 Executive Committee 15 3.4.2 Admissions Committee 17 3.4.3 Curriculum Committee 17 3.4.4 Biotechnology Industry Advisory Council 18 3.4.5 Program Coordinator 20 3.5 Budget Information 21 3.5.1. Budget Allocations and Program Expenditures 21

4. VISIONS & GOALS 23 4.1 Texas A&M University Vision 2020 23 4.2 Mission of the Interdisciplinary Faculty of Biotechnology 24 4.2.1 Program Goals 24 4.2.2 Program Objectives 24 4.2.3 Methods to Attain Goals 25 4.3 Strategic Plan To Achieve Program Goals 26 4.4 Connection to the Vision, Goals, Mission and Objectives of TAMU 28

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5. THE GRADUATE PROGRAM 30 5.1 Application Process 30 5.2 Financial Assistance for PPiB students 30 5.3 Degree Requirements 31 5.3.1 Required Core Courses 31 5.3.2 Elective Courses 32 5.4 Enrichment Activities 33 5.5 Students 34 5.5.1 Program Enrollment Trends 34 5.5.2 Applicant Quality Profile 36 5.5.3 Student Demographics 37 5.5.4 Program Students and Graduates 38 5.6 Program Assessment Benchmarks 39 5.6.1 Student Evaluation of Instruction 40 5.6.2 Facilities & Resources for Advancing Student Training 40 5.6.3 Student Satisfaction Survey 43

6. BIOTECHNOLOGY FACULTY 44 6.1 Faculty Profile 44 6.2 Faculty Reinvestment Program and the Biotechnology Program 46 6.3 Faculty Involvement in Teaching 47 6.4 Faculty Honors and Recognition 48

7. STRENGTHS AND WEAKNESSES OF THE PROGRAM 49 7.1 Program Strengths 49 7.1.1 Faculty Expertise 49 7.1.2 Curriculum 49 7.1.3 Research & Enrichment Opportunities 49 7.1.4 Quality of Incoming Students 50 7.1.5 Biotechnology Industry Involvement 50 7.1.6 Serving Texas and the Rest of the World 50

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7.2 Program Weaknesses 50 7.2.1 Program Visibility 50 7.2.2 Internship and Placement Opportunities 51 7.2.3 Domestic Student Enrollment 51 7.2.4 Program Funding 52 7.2.5 Faculty Motivation & Incentive to Participate 52

REFERENCES 53 LIST OF APPENDICES 54

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1. INTRODUCTION 1.1 Welcome Howdy! On behalf of the Graduate Interdisciplinary Faculty of Biotechnology, the students and staff of the Professional Program in Biotechnology, and the entire Texas A&M University community, let me welcome you to Texas A&M University. This may be your first visit to Aggieland. Whether this is your first visit, or you have been here before, I know you will experience the Aggie spirit and excitement on campus. Texas A&M University has just completed what many have termed the largest faculty expansion program anywhere. We recruited over 475 new faculty members across campus over the last five years! This external review is a required periodic review of all Texas A&M University academic programs. This is the first external review of the Biotechnology program and this document was prepared specifically for this purpose. The document provides an overview of the program, its history, faculty, students, curriculum, and our overall efforts at developing Science Managers. We are honored you are serving on this review, and we value the experience you bring to the process. We look forward to your feedback as we strive for excellence. If you have questions prior to your visit to campus in February please let me know.

Suresh D. Pillai, PhD Chair, Graduate Interdisciplinary Faculty of Biotechnology Professor of Microbiology & Texas AgriLife Faculty Fellow Director, National Center for Electron Beam Research

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1.2 Charge to the Review Team Dr. Robert C. Webb (Interim) Dean of Graduate Studies requests you to review the graduate program of the Professional Program in Biotechnology, a Professional Science Masters program using materials that you are being provided, information you gain through personal interactions while visiting Texas A&M, and any additional information that you might request. While evaluating the program, which is one of ten graduate interdisciplinary programs at Texas A&M University, please do consider the allocation of human and fiscal resources within the program and the level of support the Biotechnology Program receives from the University. Please comment as appropriate on current and potential leveraging of these resources, as well as the current and potential interaction with other departments and groups, both on and off campus. Also, please address the issue of learning-based outcomes:

• Is the program effectively accomplishing its mission? • Does the program have ongoing and integrated planning and evaluation processes that result in continuous improvement? • Does the program have evidence of improvement based upon analysis of results?

Additionally, we ask that you address the impact of the Faculty Reinvestment Program, started by Texas A&M University in 2003. The Reinvestment Program has resulted in the hiring of over 475 new faculty members across the University. The goal was to improve the quality of education for Texas A&M students by having more faculty available for mentoring and advising, whether more courses and sections are available, or by simply being more responsive to student needs. We ask that you assess the success of the Faculty Reinvestment Program in terms of providing enhanced graduate education, and training opportunities for the students in the Biotechnology Program.

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2. TEXAS A&M UNIVERSITY SYSTEM 2.1 The University System The Texas A&M University System (TAMUS) is one of the larger systems of higher education in the U.S. The System is comprised of 11 universities (Fig.1) , 7 state agencies, and a health science center. TAMUS educates more than 115,000 students and serves about 15 million Texans each year. With nearly 27,000 faculty and staff, TAMUS has a physical presence in 250 of the state’s 254 counties and a programmatic presence in every Texas county. TAMUS brings in more than $ 675 million annually in externally funded research helping to drive the state’s economy. Figure 1 Texas A&M University System universities

The Texas A&M University System includes: Texas A&M University – College Station (flagship university) Texas A&M University at Galveston Texas A&M University at Qatar (in the Middle East) Prairie View A&M University Texas A&M University at Commerce Tarleton State University at Stephenville West Texas A&M University at Canyon Texas A&M University at Kingsville Texas A&M University at Corpus Christi Texas A&M International University at Laredo Texas A&M University at Texarkana Texas A&M University Central Texas at Killeen Texas A&M University at San Antonio

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Texas A&M Health Science Center, College Station

The Texas A&M University System Agencies include: Texas AgriLife Research Texas AgriLife Extension Service Texas Engineering Experiment Station Texas Engineering Extension Service Texas Forest Service Texas Veterinary Medical Diagnostic Laboratory Texas Transportation Institute

2.2 Texas A&M University Texas A&M University started as Texas’ first public institution of higher learning on October 4, 1876. To date, the university has awarded more than 365,000 degrees. It is one of a select few academic institutions in the nation to hold triple federal designations as a Land-Grant, Sea-Grant and Space-Grant university. It offers more than 120 undergraduate degree programs and 240 master’s and Ph.D degree programs. Texas A&M University operates 2 branch campuses and awards “Texas A&M University” degrees in Galveston and Qatar. The university also operates centers in Mexico City, Costa Rica and Italy to facilitate education, research, and outreach.

The annual research portfolio at the University is estimated to be in excess of $528 million, placing it among the top 20 universities nationwide. More than 80% of the 2,800 faculty members hold doctoral degrees. The faculty includes Nobel Prize, National Medal of Science, and Wolf Prize winners. There are over two dozen faculty members who are members of the National Academy of Sciences, National Academy of Engineering or the Institute of Medicine.

There are 48,000 Aggies currently enrolled on the main campus in College Station out of which more than 9,000 are graduate students. The university ranks as the country’s sixth largest university in terms of student enrollment. It ranks among the top US universities in attracting international students with more than 4,500 students from 120 countries. It consistently ranks among the country’s top 20 universities in terms of enrollment of National Merit Scholars. There are 10 academic colleges at Texas A&M University. These are:

• College of Agriculture & Life Sciences

• College of Science

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• Dwight Look College of Engineering,

• College of Veterinary Medicine & Biomedical Sciences,

• College of Architecture,

• Bush School of Government and Public Service

• Mays Business School

• College of Education and Human Development

• College of Geosciences

• College of Liberal Arts

The Corps of Cadets at Texas A&M University is the nation’s largest uniformed student body which commissions more officers than any other institution except for the nation’s service academies. Approximately 1,800 men and women participate on a voluntary basis leading to commissions in all four branches of the military. Texas A&M University is famed for its traditions. These include Silver Taps – a unique silent campus memorial service to honor any student who has passed away in the previous month, and Muster –when Aggies worldwide gather each April 21 to honor those Aggies who passed away the previous year.

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3. GRADUATE INTERDISCIPLINARY PROGRAMS

At Texas A&M University, graduate degrees are awarded by traditional discipline- based academic departments, as well as by graduate interdisciplinary faculties. Graduate Interdisciplinary Faculties are relatively new to Texas A&M University with the earliest such faculty being officially recognized only in 1989. The formation of interdisciplinary faculties is primarily a faculty-driven process, when faculty members and researchers from diverse academic departments who have overlapping programmatic interests, come together to capitalize on their collective strengths. According to the University rules, an Interdisciplinary Degree Program (IDP) involves a group of faculty from more than one discipline representing single or multiple colleges, organized for the purpose of enhancing research and scholarly activities and overseeing graduate education for a degree program. These interdisciplinary faculties have to mature and document their abilities to administer a graduate program before they are authorized to award graduate degrees. The process for an interdisciplinary faculty to establish and administer a graduate degree program involves meeting specific university-level requirements and approvals at various levels within the university, prior to its approval at the state-level by the Texas Higher Education Coordinating Board. Presently, there are 11 Interdisciplinary Degree Programs (IDP) at the university namely,

• Agribusiness (Master of Agribusiness) (MAB)

• Biotechnology (Master of Biotechnology) (MBIOT)

• Engineering Systems Management (MS-online)

• Food Science & Technology (MS & Ph.D)`

• Genetics (MS & Ph.D)

• Materials Science & Engineering (MS, ME, & Ph.D)

• Molecular and Environmental Plant Sciences (MS & Ph.D)

• Neuroscience (MS & Ph.D)

• Nutrition (MS & Ph.D)

• Water Management and Hydrological Sciences (MS & Ph.D)

• Toxicology (MS & Ph.D)

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3.1 Origins of the Interdisciplinary Program in Biotechnology Almost two decades ago in 1993, the Texas Higher Education Coordinating Board identified Biotechnology as a high priority area for Texas educational institutions (THECB, 1993). In 1995, a joint study by the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine pointed out that a variety of employment options were available to graduate scientists and engineers who have multiple disciplines, minor degrees, communication skills, and entrepreneurial initiative (NAS, 1995). The report recommended that graduate students be provided with experiences that provide career skills such as the ability to communicate complex ideas to non specialists and the ability to work well in teams and that off-campus internships in industry and government would be useful in developing these skills. The Texas Governor’s Science and Technology Council Report identified that workforce issues were the largest barrier to continuing the economic growth of Texas technology based economy (TSTC, 1998). These reports and findings were in alignment with the Kellogg Commission’s recommendations (Kellogg Commission, 1999) that modern institutions 1. must be organized to respond to the needs of “today’s” and “tomorrow’s” students 2. must enrich student experiences by bringing research and engagement into the curriculum and offering practical opportunities for students 3. must put their knowledge and expertise to work on community problems An internal Texas A&M University report (Zey et al., 1999) based on focus group interviews with private industry, university, TAMUS officials, and school districts also emphasized the need for

• Broad multidisciplinary curricula

• Encouragement for students to take courses on the interdisciplinary boundaries

• Writing courses that integrate technical knowledge with communication skills

• Internal internships and co-op programs for students

• Faculty and industry to be brought together

• Alliances to be developed between the universities and corporations to enhance learning and future employment

• Curriculum advisory groups to be created with industry agencies to assist faculty in developing more relevant curricula

• Ethics-based decision making training to be provided using work-related examples

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• Seminars and capstone courses

• Teamwork learning skills and adaptation to change Texas A&M University life sciences faculty also believed that it was critical to provide for the needs of students who wished to receive specialized training to prepare for careers in science and business as opposed to the traditional graduate studies route of masters and doctoral degree programs to academic careers. As part of the planning process, an Industry Steering Committee was formed consisting of 8 executives from biotechnology related industries in Texas. They recommended that for life science students, to be of value to biotechnology companies and be competitive in the market place, the students required knowledge of

♦ Patent claims, patent searches, patent filing, what constitutes an invention

♦ Project management

♦ Drug development pipeline or process

♦ Regulatory, legal, financial, and social issues in biotechnology

♦ Marketing, planning, and cost accounting

♦ Teamwork, writing reports, and communication skills

♦ Standard Operating Procedures (SOPs)

♦ Good Laboratory Practices and Good Manufacturing Practices

♦ Data management with word processing databases spreadsheets and graphics software The premise of the Biotechnology program was that the program would be attractive to outstanding students interested in industry careers. It was believed that the program would attract and open doors to students who are interested in professional science careers with the potential to attain management positions within the companies they work.

The Texas Higher Education Coordinating Board approved the Professional Program in Biotechnology (PPiB) to offer the Master of Biotechnology (MBIOT) degree at Texas A&M University to the class of 2001.

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3.2 Program Overview The Professional Program in Biotechnology (PPiB) at Texas A&M University is a Professional Science Masters program. It is a non-thesis program. However, the students complete a mandatory 10-week internship and a Professional Portfolio.

The PPiB prepares science-trained professionals for careers in the rapidly-growing life science industries. These industries require professionals with a unique combination of knowledge and skill, not only of science, but also of business and communication. This unique combination is not readily available in most traditional life science degree programs. The PPiB program at TAMU aims to fulfill this critical need of specially- trained students. The MBIOT students are also eligible for a Certificate in Business at the completion of their studies.

The PPiB prepares graduates with an understanding of science, business, management, and communication through an interdisciplinary program of graduate classes and extracurricular experiences. The students enroll in classes offered across the university. Students gain practical experience through required laboratory courses, campus research opportunities, and a mandatory professional internship. The program is structured to provide formal and informal components to ensure that students think critically, solve problems creatively, work in teams cooperatively, and communicate and present effectively.

The goals for this program are to produce high quality Science Managers. The program aims to attract high-achieving students who wish to pursue careers in the biotechnology industry. By offering an interdisciplinary curriculum, the program is designed to provide a foundation that will allow these students to advance rapidly in the industry. The critical components of the program are:

• 39 credit hours of science and business courses

• Hands-on laboratory courses in biotechnology protocols

• Semester-long research experience in university laboratories

• Ten week-long industry/professional internship

• Completion of a Professional Portfolio

• Active industry input via a Biotechnology Industry Advisory Council

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3.3 University Administration of the Biotechnology Program 3.3.1 IDP Management (2005- late 2008) The Faculty of Biotechnology was originally administered (until late 2008) by the Office of the Vice-President for Research (VPR) and Graduate Studies through what was termed the “Council of Participating Deans” (COPD). The COPD, responsible for program oversight and budgets was made up of Deans of Colleges that were involved in the interdisciplinary programs. The Deans from the College of Science, College of Agriculture & Life Sciences and the College of Veterinary Medicine & Biomedical Sciences provided oversight of the Biotechnology program. (Fig. 2). The Biotechnology program Chair met annually with the COPD and VPR and provided annual program reports.

Figure 2: University administration of PPiB from 2005- late 2008

Interdisciplinary graduate programs, unlike conventional department-based programs, are at a disadvantage when it comes to budgets, administrative support, etc. Unlike traditional discipline based academic departments which have a history of administrative structure and support within the university, interdisciplinary programs are relatively new. Hence, the university’s experience in administering such programs are also relatively limited. In the administrative model that existed prior to late 2008, the student enrollment numbers in PPiB was administratively counted or linked to the COPD. Enrollment figures for graduate students in the program were not “counted” as part of any academic department. Therefore, the formula funds associated with the students in the program did not filter through or reach the academic departments. Thus, there was a sense that the interdisciplinary programs were somehow competing with the academic departments. The IDP Chairs believed that a number of administrative, logistical, and financial issues arose from this situation. Self-study reports from other IDPs such as Genetics and Toxicology also highlighted these problems. In response to these concerns, in late 2008, the university re-organized the administrative management and oversight of the Interdisciplinary Degree Programs.

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3.3.2 IDP Management (Late 2008-- Present) In late 2008, the university’s administrative structure for managing IDPs changed. The university’s current administrative structure for managing the PPiB is shown below (Fig 3). The key change is that the program now has a “home” Dean. The program is ad- locked to the College to which the majority of the major professors of the program’s students belong. Since a majority of the PPiB students’ graduate committee Chairs belong to the College of Agriculture & Life Sciences, the Dean of this College has overall responsibility over this program. The Offices of the VPR and Graduate Studies partner with the College in attempting to ensure seamless financial and other functions. This administrative structure is a significant improvement over the previous model.

Figure 3 Current university administrative structure of the Biotechnology Faculty

The “home” department of IDPs such as PPiB generally belongs to the department to which the Chair is ad-locked. From 2002 to 2004, PPiB’s “home” was the Department of Entomology because the Chair at that time, Prof. Linda Guarino, was in the Department of Entomology. Since late 2004 when Prof. Suresh Pillai took over as Chair, PPiB has been “housed” in the Department of Poultry Science. The “home” department provides office space, part-time secretarial support and accounting functions. These services are provided pro-bono and can be a cause of angst in the home department when it comes to housing IDPs .

3.4 Administrative Structure of the Professional Program in Biotechnology The Interdisciplinary Faculty of Biotechnology administers the Professional Program in Biotechnology. The Biotechnology Faculty is currently made up of 63 members. The faculty represent 21 academic departments at Texas A&M University, 1 academic department from the Texas A&M Health Science Center, the TAMU Office of Technology Commercialization and the USDA-Forest Service. The administrative structure of the Biotechnology program is shown in Figure 4.

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Figure 4 Administrative structure of the Biotechnology program

3.4.1 Executive Committee The Biotechnology Program’s Executive Committee consists of 7 elected members, one each from the 5 academic colleges plus 2 at-large representatives. Executive Committee members serve for 3 years. The Chair of the Executive Committee serves as the Chair of the Professional program in Biotechnology. The current members on the Executive Committee are:

Suresh Pillai, Chair –Biotechnology Program Professor of Microbiology & Texas AgriLife Research Fellow; Departments of Poultry Science & Nutrition and Food Science Director, National Center for Electron Beam Research, College of Agriculture & Life Sciences (at-large representative)

Clare Gill, Vice-Chair Associate Professor, Department of Animal Sciences, College of Agriculture & Life Sciences

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David Blackwell Associate Dean for Graduate Programs, Republic Bank/J.W. Aston Professor of Finance, Department of Finance, Mays Business School

Christian Hilty Assistant Professor, Department of Chemistry, College of Science

Zivko Nikolov Dow Professor Department of Chemical Engineering ; Biological & Ag. Engineering, Colleges of Agriculture & Life Sciences & Dwight Look College of Engineering (at-large representative)

Victor Ugaz Associate Professor & Kenneth R. Hall Professorship, Department of Chemical Engineering Dwight Look College of Engineering

Jane Welsh Professor& Associate Dept Head, Department of Veterinary Integrative Biosciences; Vet Pathobiology College of Veterinary Medicine & Biomedical Sciences

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The Executive Committee provides programmatic oversight of the Biotechnology program. The principal functions of the Executive Committee are to review courses and programs with the faculty and to make recommendations for change with the aim of maintaining excellence. The Chair is expected to provide leadership in short and long- term planning for the Biotechnology program, represent the faculty group to the university administration, coordinate the recruitment of graduate students, approve graduate student admissions, and direct graduate student advising.

3.4.2 Admissions Committee The Admissions Committee screens, evaluates, and recommends the admission of students to the PPiB (Table 1). Table 1 Biotechnology Program Admissions Committee

Member Affiliation Suresh Pillai College of Agriculture & Life Sciences Clare Gill College of Agriculture & Life Sciences Luc Berghman College of Agriculture & Life Sciences Wenshe Liu College of Science Robert Alaniz TAMU- Health Science Center

3.4.3 Curriculum Committee The Curriculum Committee has the responsibility for coordination of the graduate curriculum (Table 2).

Table 2 Biotechnology Program Curriculum Committee Member Affiliation Nancy Ing College of Agriculture & Life Sciences Clare Gill College of Agriculture & Life Sciences Paul de Figueiredo College of Agriculture & Life Sciences Zivko Nikolov Dwight Look College of Engineering Judith Ball College of Vet Med & Biomed Sci

Additional details regarding nominations, membership and elections to the Interdisciplinary Faculty of Biotechnology and Professional Program in Biotechnology (PPiB) program committees are detailed in the program bylaws (Appendix A).

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3.4.4 Biotechnology Industry Advisory Council A Biotechnology Industry Advisory Council is actively involved in the Biotechnology program (Table 3). Membership to the Advisory Council is by invitation. There is no financial commitment either by Advisory Council members, or by TAMU. The Council members pay their own expenses to attend these meetings on the TAMU campus.

Table 3 Biotechnology Program Industry Advisory Council Membership

Name Title Affiliation

Bill Lemons Human Resources Manager Kelly Scientific Resources

Bruce Leander Formerly Ambion & BioAustin

Dalal Murgai President & Prin. Consultant Regulatory Outsource Consulting, Inc. Eloy Corona Trait Stewardship Lead Monsanto

Fuller Bazer Distinguished Professor Texas A&M University

Jason Moore Vice-President PLx Pharma, Inc.

Jim Williams Formerly Opexa Therapeutics, Inc

Mary Pat Moyer CEO and CSO INCELL Corporation

Matthew Lorence VP, Sales & Marketing Tessarae, Inc.

Michael Dilling , Chair Sr. Licensing Associate Baylor College of Medicine

Mimi Healy General Manager Bacterial Barcodes, Inc/Bio- Merieux Oliver Murphy President Lynntech, Inc.

Pamela Mabry Formerly, Encysive Pharma Inc.

Peter Schuerman Director, Licensing & IP Texas A&M University System

Steven Navran Chief Scientist Synthecon, Inc.

Sushil Sharma Assistant Director Govt. Accountability Office

Vijay Pillai Director, Life Sciences Oracle Corporation Between 2000 and 2004, the Council included members who were part of the initial planning process for the PPiB. Since 2004, when Prof Pillai took over as Chair, the Advisory Council membership has been broadened in scope to include government, external and internal university representatives, and biotechnology industry representatives from around the U.S. The Advisory Council serves as an advisory group to the faculty and students of the Biotechnology Program. Additionally, it is envisioned

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that the Council will also provide feedback to the university administration regarding the program. Members provide guidance in terms of:

• Academic training provided to the students • Developing skills to be successful in industry • Strengthening the curriculum to be responsive to industry needs • Improving the career opportunities of the graduates • Increasing program visibility • Enhancing student recruitment • Developing internship and placement programs

The Council meets once a year on campus for a day-long meeting. During these meetings, the Advisory Council interacts with the PPiB students, faculty, and TAMU administrators. Attendance at these Advisory Council meetings is mandatory for all PPiB students. The Biotechnology faculty members are invited and strongly encouraged to attend. Administrators within the academic program decision- making process such as the “Home” Dean, Deans of the Participating Colleges, the Dean of Graduate Studies, and all Department Heads of the participating faculty are invited to the meeting. Representatives from the and Dean’s office do attend these meetings and interact with the Council members. The TAMU Career Center professionals are also invited to this meeting. The meeting agenda and format are designed specifically to facilitate interaction between the Council members, students, faculty, and administrators. An example meeting agenda and Program report presented by Prof. Pillai at one of the meetings is included (Appendix B). The PPiB Chair provides a yearly report. The meeting provides a forum for the Advisory Council members to meet and have a conversation with the administrative leadership from the participating Colleges, Office of Graduate Studies, and the VPR’s Office. The discussions with the administrators cover topics related to program budgets, fostering industry involvement, enhancing career opportunities, student recruitment and overall program development. The input and feedback from these past meetings have helped fine-tune the program in terms of student recruitment, student training, and internship programs.

Initially, the Council met twice a year during the spring and fall semesters. However, due to scheduling and other reasons the meetings were changed to just one meeting a year during the fall semester (except in 2009 when it did not meet). The Council meetings have been moved to the spring semester. The next meeting will be in April

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2010. A reason for moving the Advisory council meetings to the spring semester is to allow the students a semester to adjust to the graduate program and be better prepared to fully engage the council members.

3.4.5 Program Coordinator Between 2004 and late 2008, all day-to-day activities of the program were being handled by the program Chair. However, due to the growing student enrollment, there were significant challenges related to student applicant tracking, student advising, and developing a systematic internship program. The program Chair, in addition to having responsibility to the Biotechnology program, also has the usual research and teaching responsibilities in his home department as Professor of Microbiology, as well as serving as the Director of the National Center for Electron Beam Research. With the change in the university’s management of the IDPs in late 2008, and a recognition of the challenges faced by the program, especially as it related to internship placement, the Dean of the College of Agriculture and Life Sciences funded a part-time Program Coordinator position for 2 years.

In the fall of 2008, the Professional Program in Biotechnology recruited, and hired Ms. Marian Cothran as the Biotechnology Program Coordinator. Ms. Cothran brings with her 15 years of experience as a community college Biology and Environmental Science Technology professor. At the University of Kentucky Lexington Community College she helped establish a new Environmental Science Technology degree program and served as the program’s first coordinator. In that capacity she recruited business, government, and educational leaders to serve on the program Advisory Council. She was successful in establishing student scholarship and internship opportunities, and facilitated job placement following graduation. Ms. Cothran also has research experience spanning aquatic community ecology to bovine genomics.

The primary responsibility of this position is to assist in the identification, recruitment, and establishment of an internship program for the PPiB students with local, regional, state, national, and international biotechnology companies. Another key responsibility is to assist the Chair in developing an aggressive recruitment and retention plan for high quality US students.

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3.5 Budget Information 3.5.1 Budget Allocations and Program Expenditures The following is the budget allocation from FY 2006 – FY 2010 to the Professional Program in Biotechnology.

FY 2006 College of Agriculture & Life Sciences $ 5,000 (operating) College of Science $ 5,000 (operating) College of Veterinary Medicine $ 5,000 (operating) Office of the VPR $10,000 (10 Regents Fellowships) Total $ 25,000

FY 2007 College of Agriculture & Life Sciences $ 5,000 (operating) College of Science $ 5,000 (operating) College of Veterinary Medicine $ 5,000 (operating) Office of the VPR $ 10,000 (Regents Fellowships) Total $ 25,000

FY 2008 College of Agriculture & Life Sciences $ 5,000 (operating) College of Science $ 5,000 (operating) College of Veterinary Medicine $ 5,000 (operating) not received Office of the VPR $ 9,500 (Regents Fellowships) Total $ 19,500

FY 2009 College of Agriculture & Life Sciences $29,732* College of Science $5,000 (operating) College of Veterinary Medicine $5,000 (operating) not received Office of the VPR $9,500 (Regents Fellowships) IEEF Fees $11,297 Total $ 55,529

FY 2010 College of Agriculture & Life Sciences $ 40,778* College of Science $ 5,000 (operating) Office of the VPR $ 9,500 (Regents Fellowships) College of Veterinary Medicine $ 5,000 (operating) not received IEEF Fees $ 11,297 (estimated based on FY 09) Total $ 66,575

*2-year commitment by the Dean’s office includes BIOT course instructor and part-time coordinator positions. Additionally, the “home” department (Poultry Science) provides

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accounting and part-time secretarial support.

The following is the breakdown of the expenditures by the Biotechnology Program in FY 2009 and FY 2010 estimates (to date). Category FY 2009 FY 2010 Graduate Student Enhancement Regents Scholarships $ 9,500 $ 9,500 BIOT Laboratory Supplies $ 10,955 $ 11,000 (estimated) Course Instructors $ 4,100 $ 20,020

Administrative Support Salaries $ 21, 982 $ 26,778 Supplies & Materials $ 5,831 $ 4,500 (estimated) Travel & Telephone $ 2,248 $ 2,550 (estimated) Total $ 54,616 $ 74,378

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4. VISION & GOALS 4.1 Texas A&M University Vision 2020 In 1999, Texas A&M University articulated Vision 2020, a vision to become a consensus leader among peer public institutions. Vision 2020 is intended to create a Culture of Excellence at the University and put TAMU in the top-ten best public universities by the year 2020. The vision, developed with input from more than 250 stakeholders, involves benchmarks which, if achieved, would enhance the value of Texas A&M University to the Texas A&M University System, the State of Texas and the nation. Vision 2020 identified twelve specific areas of focus or imperatives, that the university would target over the course of two decades. The 12 Imperatives are: 1. Elevate the Faculty and their Teaching, Research, and Scholarship 2. Strengthen the Graduate Programs 3. Enhance the Undergraduate Academic Experience 4. Build the Letters, Arts, and Sciences Core 5. Build on the Tradition of Professional Education 6. Diversify and Globalize the A&M Community 7. Increase Access to Knowledge Resources 8. Enrich the Campus Environment 9. Build Community and Metropolitan Connections 10. Demand Enlightened Governance and Leadership 11. Attain Resource Parity with the Best Public Universities 12. Meet the Commitment to Texas Former Texas A&M University President Robert Gates (who served from August 2002 – December 2006, before he was sworn in as the 22nd Secretary of Defense) embraced Vision 2020 and elected to focus on areas embedded in the original imperatives, plus one new imperative, namely: • Elevate the Faculty and Their Teaching, Research, and Scholarship

• Improve graduate and undergraduate programs

• Diversify and Globalize the A&M Community

• Improve space

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The Academic Master Plan (2010-2015) is the strategic plan for achieving key aspects of Vision 2020. The Academic Master Plan has 3 roadmaps, namely: the Teaching- Learning Roadmap, the Research Roadmap, and the Engagement Roadmap. 4.2 Mission of the Interdisciplinary Faculty of Biotechnology The principal function of the Interdisciplinary Faculty of Biotechnology is the administration of the graduate programs leading to the Master of Biotechnology, in conformance with the rules of the Office of Graduate Studies of Texas A&M University. The Faculty also strives to promote and facilitate communication among students and industry and to foster the development of biotechnology at Texas A&M University and other components of TAMUS. The primary mission of the Professional Biotechnology Program is to train master's level students to be competitive for employment in the biotechnology and affiliated industries. This will be achieved by providing the students a rigorous curriculum that encompasses classroom and laboratory courses in molecular biotechnology, technical writing, management, accounting, finance and marketing. A key component of the curriculum is the blend of business and biotechnology courses along with a required 10- week internship that provides the student a meaningful professional experience.

4.2.1 Program Goals 1. Recruit high quality US and international graduate students to the program 2. Recruit active researchers to the biotechnology faculty 3. Retention of graduate students in the biotechnology program 4. Active participation of the biotechnology industry in the biotechnology program 5. Ensure that students graduate from the program within the expected time- frame 6. Enable students to secure professional internship opportunities 7. Enable students to find full-time jobs within the biotechnology industry 4.2.2 Program Objectives 1. Graduates will demonstrate a basic knowledge of biotechnology 2. Graduates will be proficient in laboratory protocols that involve DNA and protein manipulations 3. Graduates will have an understanding of basic business principles 4. Graduates will demonstrate critical thinking and creative problem solving skills

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5. Graduates will gain experience of working in multidisciplinary teams 6. Graduates will be proficient in making effective presentations 7. Graduates will be proficient in writing and speaking 8. The graduates will have a basic understanding of bioethics and understand how these issues could affect them in their professional careers 9. Synergistic collaborations will develop among the Biotechnology program faculty resulting in additional student enrichment opportunities 10. Collaborations between the Biotechnology faculty and the biotechnology industry will lead to additional student learning and enrichment opportunities 4.2.3 Methods to Attain Goals 1. PPiB will prepare graduates with an understanding of science, business and communication through an interdisciplinary program of graduate classes and co-curricular experiences. 2. PPiB will prepare students to enter their corporate careers with hands-on training in laboratory techniques and through laboratory research experiences. 3. PPiB students will be required to participate in laboratory research with Biotechnology faculty members. 4. PPiB students will gain practical experience through industry internships and campus research opportunities. 5. PPiB will be structured to provide formal and informal components to ensure that the students think critically, solve problems creatively, work in teams cooperatively, communicate, and present effectively. 6. PPiB students will have to pass a final oral exam that will be administered by the students’ advisory committee. 7. The final exam will be structured to permit the students to exhibit their depth of technical knowledge and understanding of laboratory techniques. 8. The final exam will be the opportunity to demonstrate internship-acquired skills. 9. Students in the program will be encouraged to interact with as many of the Biotechnology program faculty as possible.

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4.3 Strategic Plan To Achieve Program Goals A 5-year strategic plan was developed in 2008 by the program Chair in consultation with the Executive Committee (Appendix C). The strategic plan was developed based on faculty ideas, faculty concerns, program trends, biotechnology industry trends, and Advisory Council input. Student enrollment in the program was increasing significantly. However, there was an asymmetrical increase in international students in the program as compared to US domestic students. A resulting trend that was observed was the inability of many of the international students to secure an industry internship or jobs. Some of the challenges included immigration paperwork that small to medium sized biotech companies were being burdened with, caps on H-1B visas, etc. There were other programmatic issues due to course sequencing. For example, BIOT 601 and BIOT 602, the two key courses of the program were being offered only during the 10-week summer session. Thus students were not able to seek internships in the summer and had to look for internships during the Fall or subsequent Spring semesters (which are not the usual periods in which industry offers internships). These constraints along with the relatively small pool of biotechnology-related companies in Texas resulted in students substituting industry internships with on-campus research internships.

In order to achieve the benchmarks identified in the strategic plan, specific goals and action plans were formulated. The following are the Goals and Action Plans that were established 1. Hire a Program Coordinator Why: The program Chair obligated by his own research and teaching commitments, could not commit enough quality time to student recruitment, advising, and internship program development Status: The College of Agriculture & Life Sciences provided funding to hire a part-time Program Coordinator in late 2008. The coordinator has been hired. 2. Increase the percentage of U.S. citizens enrolled in the program from 17% (6 of 35 students in Fall 2009) to 50% in Fall 2010 Why: U.S. students usually come to the program with more undergraduate laboratory experience, have an easier time acquiring internships, and move more easily into the U.S. job market than international students. Action Plan: ·Create new website, LinkedIn™, and Facebook™ pages ·Coordinate with Office of Graduate Studies recruiter to receive names of prospective students ·Follow up promptly with all program inquiries ·Utilize OGS recruitment funds to bring selected U.S. students for campus visits ·Make admission decisions and notify students of acceptance and scholarships within 2 weeks of March 1st application deadline ·Recruit at Graduate and Professional Career Day ·Publicize program to TAMU undergrads via University email system ·Make presentations about PPiB to student groups Status: On-going

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3. Develop benchmarks for evaluating international applicants Why: Many of the applicants are from India and there needs to be a formal or standardized process to evaluate the credentials. This will help the admissions committee Action Plan: Admissions Committee to work with the Office of Admissions and faculty networks to develop information on quality of overseas educational institutions. Status: On-going 4. Increase funding for BIOT 601/602 instruction from 20 % to 50% release time Why: We need to count on high quality instruction in our program. An investigation of COALS policy for release time revealed variability between departments within the college; however, generally it was 25-33% for 3 credit hours of instruction. Since BIOT 601/602 are 4 credit hour labs (8 contact hours) and require supervision of a lab preparer, we are requesting funding for 50% release time. Importantly, with this arrangement, the program can offer BIOT 601 and BIOT 602 during the regular semesters instead of the summer session. Action Plan: Meet with the Dean’s office and identify necessary type of funds. Status: The Dean’s office has identified the necessary funding options. BIOT 601 and BIOT 602 will be offered during the Fall and Spring semesters starting Fall 2009. The funding for the instructor has been increased to 50% 5. Develop benchmarks for students completing BIOT 685 courses Why: Currently there is no basis for evaluating the quality of research or professional training that the students are receiving as part of this course. Also, it would give faculty (and students) some guidance on expectations and scope of what the students should accomplish. Action Plan: Executive Committee and Curriculum Committees to address this issue Status: Pending 6. Develop GMP/GLP and Drug Development courses as program electives Why: These ideas have been continually suggested by the Biotechnology Industry Advisory Council and other industry speakers. Action Plan: Partner with the Department of Chemical Engineering in submitting an NSF proposal for an integrated PSM program in Biotechnology and Therapeutics Manufacturing that would offer these courses Status: An Industry Advisory Council member (Jason Moore) offered a 3-credit hour course titled “Biopharmaceutical Development & Marketing” during summer 2006. An NSF proposal in collaboration with the Chemical Engineering Department was recently submitted. Funding to hire an instructor to teach such a course is being explored. 7. Increase percentage of students interning with biotechnology companies (versus university-affiliated and non-profit institutions) from 22% (2009) to 33%. Why: The original purpose of offering this new degree plan was to accommodate the needs of industry for Science Managers. However, many of the students are not able to find industry internships and many are not obtaining jobs in industry. Action Plan: ·Develop a plan or formal procedure for Advisory Council members to communicate opportunities to the program and provide input ·Seek new members for our Advisory Council from biotechnology companies that

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currently support dedicated internships and co-ops for students ·Continue to promote the PSM degree and PPiB to businesses, especially targeting those that have hired our students in the past ·Attempt to coordinate Biotechnology seminar series with other entities on campus that allow students to interact with industry representatives Status: Texas-based companies that have hired PPiB graduates are being recruited/ invited to join to the Advisory Council. 8. Increase the percentage of students graduating in 2 years from 55% to 80%. Why: the program is designed as a four-semester, non-thesis Master’s program. Graduation rate is recognized as an indicator of program quality and timely progression through the program lowers the costs and increases the benefits for students. The major impediment to timely graduation is securing an internship. Action Plan: ·Present overview of program and curriculum at mandatory orientation for new students in August ·Create Internship and Portfolio Handbook as reference guide for students ·Present seminar every fall semester on the internship search process to new students ·Facilitate attendance and networking of students at area internship/job conferences such as BioHouston’s Life Science Career Forum ·Monitor students’ progress in the program and be prompt in resolving registration or degree plan problems Status: On-going 9. Increase scholarship and program development funds Why: The program requires enhanced funding to cover critical expenses such as student field trips, internship and job placement-related expenses, expenses to cover biotechnology industry seminar speakers, and expenses to cover the Advisory Council meetings Action Plan: To meet with the “Home” Dean’s office to emphasize the need for the university to institute Biotechnology program fees or secure additional funding. Also, meet with the TAMU Development Office to seek ways to secure endowment funds from friends of TAMU Status: On-going

4.4 Connection to the Vision, Goals, Mission and Objectives of TAMU The Interdisciplinary Faculty of Biotechnology is committed to contributing to the relevant Vision 2020 imperatives. Specifically, it is aimed at making sure that the goals and action plans are aligned with: Imperative # 2: Strengthening our graduate programs Imperative # 5: Building on the tradition of professional education Imperative # 6: Diversifying and globalizing the A&M community Imperative # 12: Meeting our commitment to Texas The Biotechnology program faculty have spent considerable effort identifying and implementing different approaches to strengthen the Professional Program in

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Biotechnology. The major change in the course offering of BIOT 601 and BIOT 602 to a regular semester (rather than the summer sessions) and the hiring of a dedicated instructor for this course is one such example. Additionally, the efforts of the program coordinator to manage a robust and sustainable internship program is an example where the program is investing heavily in the professional development of the students.

The Biotechnology program adds to the wealth of diversity and globalization on the university campus. Though we are focusing our efforts to increase the number of high quality U.S. students to the program, we are also continuously attempting to recruit the best and the brightest students from around the world.

The program makes every effort to work closely with the biotechnology industry around Texas. The program is an active participant in activities sponsored by regional biotechnology consortia such as BioHouston and BioAustin. These interactions are meant to serve as two-way channels so that the industry looks to the faculty as a technical resource as well as a resource for trained personnel. Similarly, the faculty use these connections to explore potential research and commercialization opportunities. The Professional Program in Biotechnology at Texas A&M University is one of only two Professional Science Masters programs in Biotechnology in Texas. Thus, PPiB has a unique opportunity to make a profound impact in the state.

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5. THE GRADUATE PROGRAM 5.1 Application Process Students are now being admitted to the PPiB only during the fall semesters. Applicants to the Professional Program in Biotechnology (PPiB) apply online to Texas A&M University (www.applytexas.org). The application includes the uploading of an essay detailing the career goals of the applicant. In addition to the goals essay, the applicant is required to arrange for 3 letters of recommendation to be sent via the Application Information System website. The student will have access to the site to monitor the status of their application, once the application is complete and received by Texas A&M University. The official transcripts have to be sent to the Graduate Admissions Processing Office. In addition, applicants to the PPiB are required to submit GRE (General Test) scores and TOEFL scores. The stated minimum eligibility is a science- based baccalaureate degree with a 3.0 GPR. (In exceptional circumstances, the minimum GPR requirement may be waived if the applicant has demonstrated capabilities, potential for success in the program and truly outstanding letters of recommendation).

Once the documents are entered into the electronic database by the Admission Processing Office, the applications are available to the PPiB for admission decisions. The administrative assistant is responsible for the organizing of the applicant materials. The Program Coordinator and the Administrative Assistant analyze the applicant credentials and present them to the Admissions Committee. The Admissions Committee then makes the admission recommendation to the Chair. The PPiB Chair then communicates with the applicants via email about the status of their application. The deadline for the fall admission is March 1 for all international and US students who want to be considered for scholarships. The deadline for admission is extended to June 1 for US students (however, they are not eligible for scholarship monies).

5.2 Financial Assistance for PPiB students The PPiB offers neither teaching nor research assistantships nor fellowships. However, PPiB students are eligible for teaching or research assistantships through other departments or research programs. The only financial assistance that is currently available to PPiB students is $9500 Regents Fellowship funds. Each year, the program receives $ 9500 in Regents fellowship funds from the VPR’s Office for new incoming students. Rather than awarding the entire amount to one student, the Biotechnology Faculty feels that it would be best to spread the award to as many new students as possible. Thus, the Regents Fellowship funds are divided into $1000 scholarships that are awarded on a competitive basis among the students. Sometimes, the College of Agriculture & Life Sciences also provides one-time scholarship funds to provide $1000 scholarships for about 3 to 5 students. All scholarship monies are awarded on a competitive basis. One advantage of the $1000 scholarship is that it if a student receives this scholarship it automatically waives out-of-state tuition. However, the student is still responsible for in-state tuition and fees.

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5.3 Degree Requirements Admission to the PPiB requires a science-based undergraduate degree. All students are required to complete 39 credit hours of a core curriculum to be eligible for the Master of Biotechnology (MBIOT) degree. The students upon completing the program are also eligible to obtain a Certificate in Business offered by the College of Business. The required coursework is shown below, and Appendix D has the recommended course sequence. Students have to file a Degree Plan with the Office of Graduate Studies within 2 semesters of joining the program. Filing of a degree plan will require the formation of a graduate advisory Committee consisting of no fewer than 3 members (with one member from outside the major) 5.3.1 Required Core Courses BIOT 601. Biotechnology Principles and Techniques I. (1-9). Credit 4. Basic theories and techniques essential to laboratory research in agricultural, environmental or medical biotechnology such as laboratory safety and records keeping, genome informatics, DNA analysis, RNA analysis, protein analysis and analysis of biological systems. Pre-req: Grad classification BIOT 602. Biotechnology Principles and Techniques II. (1-9). Credit 4. Application of basic theories and principles of biotechnology to team and individual research problems in a laboratory setting. Pre-req: BIOT 601; grad classification BIOT 603. Applied Principles of Biotechnology. (1-9). Credit 4. Applied experience with biotechnology laboratory procedures and instrumentation in a research environment. May be repeated twice for credit. Pre-req: BIOT 601 BIOT 635. Molecular Biotechnology. (3-0). Credit 3. Theory and application of molecular biotechnology; consideration of the structure and function of cellular components and methods to characterize these components with reference to examples in industry. Pre-req: Instructor approval; BIOT 645. Biotechnology Writing. (3-0). Credit 3. Development of biotechnology writing and editorial skills; communication of specialized information to the public and peers. Pre-req: Grad classification; instructor approval BIOT 681. Biotechnology Seminar. (1-0). Credit 1. Review and discussion of current topics in biotechnology industries, with focus on skills essential to success in the corporate environment such as communication, interviewing and interpersonal skills. Pre-req: Grad classification or instructor approval BIOT 684. Directed Professional Internship. (4-0). Credit 4. A directed internship in an organization to provide students with on-the-job training with professionals in organizational settings appropriate to the student’s professional objectives. Pre-req: Approval of Chair of program BIOT 685. Directed Studies. Credit 1 to 4. Training and experience in biotechnology; topics can include laboratory research, scientific literature reviews, biotechnology market surveys, and training in technology commercialization. Pre-req: instructor approval BIOT 689. Special Topics in... Credit 1 to 4. Selected topics in an identified area of biotechnology. May be repeated for credit. Pre-req: instructor approval

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ACCT 640. Accounting Concepts and Procedures I. (3-0). Credit 3. Accounting concepts and relationships essential to administrative decisions; use of accounting statements and reports as policymaking and policy execution tools. Pre-req: grad classification FINC 635. Financial Management for Non-Business. (3-0). Credit 3. External and internal factors affecting financial decision-making in the firm; fundamental concepts of accounting and managerial economics. Pre-req: ACCT 640 MGMT 655. Survey of Management. (3-0). Credit 3. Management concepts and applications important to managers in all types and sizes of organizations; includes: strategic planning, goal setting, control and managerial ethics; decision making, organizing, human resource management, including staffing, performance appraisal and compensation; leadership, motivation, communication and group processes; achieving organizational quality and managing in a global environment. Pre-req: Grad classification or instructor approval 621. Survey of Marketing. (3-0). Credit 3. Marketing concepts and functions from the point of view of the organization and the economy. Pre-req: Grad classification

5.3.2 Elective Courses Molecular Biology BIOL 650 Genomics ; GENE 626 Analyses of Gene Expression Biosecurity VTMI 601 Fundamentals of Pathobiology ; VIBS 670 Basic Environmental Toxicology OR VIBS 618/619 Food Toxicology ; PLAN 616 Analyzing Risk/Hazard and Public Policy VTMI 647 Virology ; VTMI 619 Molecular Methods for Microbial Detection; FSTC 629 Microbiology of Food Irradiation Business ACCT 641 Accounting Concepts and Procedures II ACCT 642 Accounting Concepts and Procedures III FINC 629 Financial Management I FINC 642 Analysis of Money and Capital Markets FINC 645 International Finance MGMT 630 Behavior in Organizations MGMT 632 Technology Commercialization MGMT 639 Negotiations MGMT 637 Foundations of Entrepreneurship MGMT 658 Managing Projects MKTG 650 Analysis of Consumer Behavior MKTG 656 Marketing Communications Management MGMT 611 Microfoundations of Business Behavior MGMT 614 Managing People in Organizations MGMT 638 Strategic Entrepreneurship MGMT 645 Legal and Ethical Issues in Business MGMT 675 Leadership in Organizations MKTG 613 Marketing Management

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5.4 Enrichment Activities Texas A&M University fosters an environment where students can excel in academics, leadership opportunities, co-curricular, and extracurricular enrichment activities. The Biotechnology program has specific academic and enrichment activities that are aimed at promoting leadership, professionalism, collegiality, and a “sense of community” among its students and faculty (Fig 5). The Biotechnology program has specific activities directed towards the students in the program. These include the active participation of a Biotechnology Industry Advisory Council that meets once a year. This day-long meeting provides a forum where students meet with industry representatives one-on-one to seek input on professional development, career opportunities and develop networking skills.

Figure 5 Academic, research, professional and enrichment activities

The program also invites industry speakers whenever possible to the Biotechnology Seminar Series every semester. The PPiB sponsors field trips to select biotechnology companies in the region and supports the students’ attendance at the Texas Life Science Conference in Houston.

The PPiB Program Coordinator serves as the mentor to the student-run Biotechnology Society which also invites industry speakers and sponsors mock interviews. The society has office-bearers with formalized nominations and elections. The Biotechnology society helps in developing leadership skills in students. The students as members of the of the Biotechnology Society take part in the Big Event a TAMU student-run service activity in the College Station and Bryan communities. The students assist disadvantaged homeowners and households in cleaning, repairing, and re-painting yards and homes. Big Event is one of the largest student run service activities in the U.S. The Biotechnology Society also publishes a wholly student written, edited and published newsletter BT Transit quarterly. We are told that BT Transit is possibly the first PSM student-run newsletter in the country. A copy of the latest issue of BT Transit is in Appendix E.

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BioHouston, a consortium of biotechnology-related companies in the greater Houston area organizes the BioHouston Chili Cook-off every spring. The event, a casual get- together of management and staff from biotechnology-related companies in the Houston area is a great networking opportunity for the students and faculty. This event has been well attended by the PPiB students along with a few faculty members and the program coordinator.

The Interdisciplinary Faculty of Biotechnology has also helped catalyze the formation of collaborative research groups on campus (that otherwise may not have naturally happened). Research proposals from such collaborations have resulted in funded projects. A large number of the researchers involved in the university’s Research Roadmap strategic initiatives are members of the Biotechnology Faculty. These interactions and synergistic activities have a direct impact on the PPiB students since they are able to work on cutting-edge multi disciplinary research projects as part of their research training in BIOT 603. Moreover, the collaborative networks that TAMU Biotechnology Faculty members have are invaluable to the PPiB students as they develop their internship and job placement plans.

Commercialization of research is strongly promoted at Texas A&M University. The commercialization activities of the faculty are providing new and exciting opportunities for the Biotechnology program students to work on industrially-relevant projects and also interact with industry representatives. For example, a PPiB student is working at Terrabon, Inc a new investor-driven renewable energy company in the College Station area. Similarly, students who have worked in the Office of Technology Commercialization (as part of BIOT 603) in the past have found job opportunities through some of the contacts they developed. Some of these interactions are translating into internship placements and opportunities.

5.5 Students 5.5.1 Program Enrollment Trends The student enrollment in the Biotechnology program is shown in Figure 6. Originally students were admitted only during the summer session. Incoming student completed BIOT 601 and 602 in the summer, other courses during the fall and spring semesters and their professional internship in the second summer. Based on applicant feedback and demand, the program began in 2005 to admit students in spring, summer and fall semesters. However, this caused other issues related to sequencing of courses, over- enrollment in the laboratory classes, etc. The Executive Committee in consultation with the Admissions Committee, recommended that enrollment be limited to the fall semester. Starting Fall 2009, students are admitted only during the fall semester. The program attracts a large number of highly qualified applicants. In 2008, when 68 applicants were admitted, 38% (26) matriculated into the program (Fig 7).

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Figure 6: Student enrollment trends (2004– present)

Figure 7. Applicant acceptance and matriculation trends (2008-2009)

Out of 134 total applications that were processed for Fall 2009, admission offers were sent to 30 students. Of these, only 7 (23%) actually joined the program. Given that students are being admitted only during the fall semester, the Admissions Committee and the Executive Committee realize that careful attention has to be paid to

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make sure that the enrollment does not suffer. To address this issue, the application deadlines have been clearly highlighted on the webpage, and strict admission decision deadlines have been instituted.

5.5.2 Applicant Quality Profile

The PPiB program has always attracted a large pool of high quality students (based on metrics such as GRE scores, TOEFL scores, and GPR). Because the program is geared towards training high quality science professional with strong oral and written communication skills, the admissions committee has used the TOEFL scores and the statement of purpose as indicators of applicants’ communication skills. The admissions committee does recognize that these scores are not perfect indicators and are working towards developing standardized benchmarks to compare different applicants from around the world. Figure 8 shows the shows the median GRE scores (Verbal + Quantitative) of those who applied, who actually enrolled or matriculated into the program over the past 2 years

Figure 8: Median GRE scores (verbal + quantitative) of applicants (2008-2009)

Figure 9 shows the average GPR of the students admitted and enrolled in the program. However, it needs to be highlighted that conversion of international grades into US 4.0 GPR system is fraught with limitations. Thus evaluating international applicants in comparison to US students in terms of their GPR is challenging.

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Figure 9: Average GPR of applicants (2008-2009)

5.5.3 Student Demographics There were 35 students who were enrolled in the PPiB program during fall 2009. The demographics of these students in terms of gender, citizenship, race/ethnicity are shown in Figures 10A, 10B, and 10C.

Figure 10A: Gender breakdown of currently enrolled PPiB students

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Figure 10B: Nationality of currently enrolled PPiB students

Figure 10C: Race/ethnic breakdown of currently enrolled PPiB students

5.5.4 Program Students and Graduates

Figure 11 provides a breakdown of the internship locations (TAMU on-campus as compared to off-campus internship locations) for PPiB students to date. When the program initially started most of the students were seeking internships during summer. Moreover, most of the students were US citizens. Hence it was easier for them to find off-campus internship locations. When the program’s enrollment increased (and when they were seeking internships during the regular semester) the students found it challenging to find off-campus internships. This, coupled with the deteriorating US economy, recently has forced many of the students to complete their course requirements using on-campus internship arrangements. Of all internship locations, 71% were off-campus and 29% were TAMU on-campus locations. A listing of all internship locations is in Appendix F.

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Figure 11: PPiB student internship locations since program inception (2001-2009)

To date, 88 students have graduated from the program. Of these, 56% (49 students) have been female (Fig. 12). Appendix G provides a listing of program graduates.

Figure 12: Gender breakdown of PPiB graduates since program inception (2001- 2009)

5.6 Program Assessment Benchmarks The Biotechnology Faculty has in the past provided Annual Reports to the Office of the VPR. These reports were to be shared with the Council of Participating Deans, and other administrators. More recently in summer 2009 with the re-organization of the administrative structure overseeing the Biotechnology Faculty, the Chair (Prof. Pillai) and Vice Chair (Prof. Gill) met with the Dean of the College of Agriculture and Life Sciences (Prof. Hussey), the then-Interim Executive Associate Dean (Prof. Kenimer), the Associate Dean for Graduate Programs in the College of Agriculture & Life Sciences

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(Prof. Reed), and administrators from the Office of Graduate Studies. This in-depth review along with discussions within the Executive Committee and faculty of the Biotechnology Program provides the primary mechanism of assessment to ensure that the goals of the program are being met. The benchmarks used to assess that goals are being met include the following • Quality of participating faculty • Number of applicants to the Biotechnology program • Number of U.S. applicants to the Biotechnology program • Quality assessment of the applicants (GPR, GRE scores, etc.,) • Student performance in academic coursework • Industry internship placements • Student performance during internship • Internship evaluations • Job Placement The PPiB also participates in the TAMU Office of Assessment’s online utility Weave Online which is an assessment and planning management tool. The program Chair and members of the Executive Committee have worked on completing the online benchmarking too. However, we do recognize that it is still a “work in progress” (Appendix H).

5.6.1 Student Evaluation of Instruction The Biotechnology program did not have a formalized system of student evaluation of instruction until recently. Some of the BIOT course instructors did have the students complete evaluation sheets at the end of each semester. The students did, however, evaluate the business school courses and electives. Starting fall 2009, all Biotechnology courses are being evaluated by the students using an anonymous online system. The following are some sample questions from the evaluation form for BIOT 681 (Biotechnology Seminar) ⇒ The objectives of the course were clearly explained. ⇒ The instructor discussed recent developments in the field. ⇒ This class allowed me to interact with industry speakers. ⇒ This class provided me an opportunity to understand the biotechnology research being conducted at TAMU. ⇒ This class helped me improve my presentation and writing abilities.

5.6.2 Facilities & Resources for Advancing Student Training Texas A&M University is a Tier 1 Research institution and thus is very well equipped and supported. Majority of the faculty members associated with the Interdisciplinary Faculty of Biotechnology have very active research programs and hence have well equipped laboratories. In addition to individual research laboratories there are numerous research facilities that are supported by different administrative units across the campus. Below, are just a few examples of the state of the art research and development facilities that are available on the TAMU campus as resources for students.

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Biotechnology Techniques (BIOT 601-BIOT 602) Teaching Laboratory This is a dedicated teaching laboratory located in the Bio/Bio building that serves a variety of life science teaching courses on campus. The laboratory is equipped with a variety of molecular biology instrumentation, equipment and student resource aids. This laboratory can accommodate about 25 PPiB students at any one time. The Biochemistry/Biophysics department is providing the teaching laboratory free of charge to the Biotechnology program.

National Center for Electron Beam Research (NCEBR) The NCEBR serves as an un-biased venue for academic, government, and industry scientists to carry out strategic electronic pasteurization and sterilization research using electron beam (E-beam) and X-rays. The NCEBR was originally established as part of a $10 million partnership between TAMU and SureBeam Corp. The NCEBR is a one-of- a-kind research facility with E-beam and X-ray capability on the Texas A&M University. There are 2 vertically mounted opposing 10 MeV (Million Electron Volt), 18 Kilowatt Electron Beam Linear Accelerators (LINAC) and a single horizontally mounted 5 MeV, 15 Kilowatt X-Ray Linear Accelerator. These linear accelerators are used extensively in food pasteurization research, phytosanitary research, pharmaceutical product/device sterilization, material enhancement and environmental remediation. The NCEBR has in the past provided hands-on training to Biotechnology program students as part of BIOT 603. The NCEBR is one of the locations on campus that students can use as an internship location.

Texas A&M Institute for Preclinical Studies (TIPS) TIPS conducts medical device and product safety studies in large and small animal models in compliance with the U.S. Food and Drug Administration’s Good Laboratory Practice (GLP) regulations. The TIPS GLP Quality System is led by staff with over 30 years of combined experience in conducting and managing FDA GLP studies. TIPS offers a testing facility capable of providing comprehensive research services and product development support to speed the commercialization process from product inception through clinical trials. TIPS has built a state-of-the-art, 112,000 square-foot facility with sophisticated imaging, large animal hospital, animal housing, surgical laboratories, pre-op and recovery, interventional catheterization laboratory and incubator space for start-up companies. The facility is expected to encourage the growth of startup companies, allow device companies to maximize their capital and obtain maximal value for the research dollars, train veterinarians, physicians, scientists, technicians, and engineers to meet the needs of the biomedical industry, and serve as a key resource for training undergraduate, graduate, and academic and industry personnel in product development science, and create new opportunities for collaborative research with international partners. One of the MBIOT students interned at TIPS in 2009.

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Texas Institute of Genomic Medicine (TIGM) TIGM is a part of the Texas A&M University System as a research institute of the Texas A&M Health Science Center. It was originally established as a partnership between TAMU, the Institute of Biosciences and Technology and Lexicon Genetics as a part of a $ 50 million grant from the Texas Enterprise Fund. TIGM utilizes advanced technologies to discover breakthroughs in science and medicine and accelerate the pace of medical discoveries. TIGM also maintains the world's largest library of mouse knockout embryonic stem cells and provides both ES cells and mice to academic and commercial institutions around the world.

Vegetable & Fruit Improvement Center (VFIC) The Vegetable and Fruit Improvement Center (VFIC), a part of the Texas A&M University Department of Horticultural Sciences, was established in 1992 to support and strengthen the total vegetable industry through research. Its goal is to develop new technologies for producing quality vegetable products in an efficient, economic, and environmentally sound system, with a focus on achieving health and nutrition benefits.

Food Protein R&D Center (FPRDC) This is an engineering process development, innovation, and training center, focused on adding value to diverse biological materials, including oilseeds, grains, nuts, citrus, vegetables, waste biomass, waxes, petroleum and natural/botanical oils, liquid/fluid process streams, and water. The FPRDC is part of the Texas A&M University System through the Texas Engineering Experiment Station and managed as a center within the Chemical Engineering Department. PPiB students have interned at FPRDC. . Office of Technology Commercialization (OTC) The Office of Technology Commercialization (OTC) provides commercialization services for the entire Texas A&M University System. OTC handled approximately 300 invention disclosures in FY 2008, approximately 100 US patent applications and was issued 22 patents in 2008. In 2008, OTC managed approximately $ 10 million in patent income. The PPiB students who have interned here or worked here as part of BIOT 603 have gained valuable professional skills.

TAMU Integrative Center for Homeland Security (ICHS) The ICHS is an umbrella-type organization that covers all activities associated with homeland security within the Texas A&M University System. This Center serves as a resource for research, education and outreach needs. This Center has hosted a PPiB student in the past as part of his internship experience.

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5.6.3 Student Satisfaction Survey A satisfaction survey was sent to all second-year current students (28) and a sampling of graduates (27) of the Texas A&M Biotechnology Program in September, 2009, using the free survey tool at SurveyMonkey.com. The online survey was sent via email, and 20 students responded (36%). Of those responding, 55% (11) were program graduates and 45% (9) were currently enrolled students. Other than the question regarding the internship experience, in which 9 students selected not applicable (N/A), the software did not allow us to separate graduate from current student responses. The students were asked to rate various aspects of the program. Responses were assigned values as follows: poor=1, fair=2, average=3, good=4 and excellent=5. Aspects of the Biotechnology Program and associated average responses are listed in Table 4 below.

Table 4: Results from the fall 2009 student satisfaction survey (n=20) Program Aspect Av. Response Knowledge of basic biotechnology principles 3.90 Knowledge of basic business principles 3.50 Applicability of coursework to planned career 3.30 Ability to conduct lab procedures & evaluate results 3.65

Ability to make presentations to the public, peers 4.15 Ability to create newsletters, reports & proposals 3.30 Internship experience (graduates only) 3.64 Preparedness to compete for jobs after graduation 3.35 Adequacy of any stipend or scholarship 2.78 Availability of equipment, expertise & facilities 3.79 Quality of Biotechnology seminar speakers 3.53 Administrative support in completing your degree 3.21 Administrative support in seeking an internship 2.28 Support of faculty advisor & committee 3.21 Overall rating of Biotechnology program 3.10 Likelihood of recommending program to prospective students 2.65

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6. BIOTECHNOLOGY FACULTY 6.1 Faculty Profile The Biotechnology Faculty has interdisciplinary expertise with its 63 members holding primary appointments in College of Agriculture & Life Sciences, College of Science, Dwight Look College of Engineering, Mays School of Business, the College of Veterinary Medicine & Biomedical Sciences, and the TAMU Health Science Center (Fig. 13) Figure 13: Home academic colleges of Biotechnology faculty

Figure 14: Professorial ranks of the Biotechnology faculty

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The Biotechnology faculty has a good mix of senior experienced researchers, and mid- junior level faculty members (Fig 14) who represent 23 different academic departments (Table 5).

Table 5: Academic departments represented by the Biotechnology faculty Academic Department Participating Faculty Agricultural Economics 1 Animal Science 2 Biochemistry & Biophysics 6 Biological & Agricultural Engineering 1 Biology 5 Biomedical Engineering 1 Chemical Engineering 6 Chemistry 3 Ecosystem Science & Management 3 Electrical & Computer Engineering 1 Entomology 2 Finance 1 Management 1 Mechanical Engineering 1 Microbial & Molecular Pathogenesis 2 Nutrition & Food Science 2 Office of Tech Commercialization* 1 Poultry Science 3 Soil & Crop Sciences 4 USDA Forest Service* 1 Veterinary Integrative Biosciences 8 Veterinary Pathobiology 3 Veterinary physiology & Pharmacology 3 Non-academic departments

The complete list of the Biotechnology faculty is in Appendix I and their CVs are in Appendix J. The Biotechnology faculty is made up of 76% males and 24% females.

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The faculty participates in the program in one or more of the following roles:

• Serving as Chair of PPiB graduate student committees • Serving on PPiB graduate student committees and PPiB program committees • Teaching Biotechnology classes (BIOT 601/BIOT 602/BIOT 635/BIOT 645/BIOT 681) • Hosting students as part of BIOT 603 (research experience) • Involvement in Biotechnology Seminar series speakers or recommending seminar speakers or Advisory Council members • Providing solicited and unsolicited programmatic input • Assisting with PPiB student recruitment and placement

It needs mentioning that the number of formal “touch points” for the Biotechnology faculty members in the program are limited, because unlike thesis or dissertation-based graduate programs there is no formal requirement for laboratory rotations, the course requirements are fixed, and the elective requirements are limited. Thus, for some faculty members they may have a feeling of “not being involved”. For these reasons, all incoming students are encouraged by the program Chair to meet and introduce themselves to as many of the program faculty members as possible. A strategy that is adopted (to have students interact with more faculty) during the first semester of an incoming class is for incoming students to meet at least 3 faculty members and “interview” them about their research programs. The students then make brief a presentation of the different research programs in the seminar BIOT 681 class. This presentation not only enhances the students’ presentation skills but also provides the class a snap-shot of the research being conducted by the Biotechnology program faculty. The feedback from students and faculty has been positive.

6.2 Faculty Reinvestment Program and the Biotechnology Program Beginning 2005, the university began an ambitious faculty re-investment or recruitment program to enhance the teaching and research competitiveness of the university. To date, over 475 new faculty members have joined the TAMU community. The Biotechnology program Chair was involved in the search committees for some these positions and has also been specifically involved (as Chair of the Biotechnology program) in some of the candidates’ interviews on campus. To make the most out of the new expertise arriving on campus, and to provide additional PPiB student training opportunities, the Biotechnology program has actively sought to recruit many of these individuals to join the Biotechnology faculty.

Some faculty members have specifically sought out membership in the Biotechnology Faculty. Some of these inquiries have occurred after PPiB students have contacted these individuals about research training opportunities, part-time jobs or even on- campus internship opportunities. To date, 12 new additions to the Biotechnology program are part of the faculty re-investment hires (Table 6). New members are

Page 46 Biotechnology Program Self-Study

usually invited to present a seminar in the seminar series providing an opportunity for students and faculty. Table 6: TAMU Faculty Reinvestment hires who are members of Biotechnology Faculty

Faculty Member College Academic Department Arum Han Engineering Elect & Comp Engineering Christian Hilty Science Chemistry Chris Schwartz Engineering Mechanical Engineering Gus Cothran Vet Med Vet Integrative Biosciences Huaijun Zhou Ag. & Life Sci Poultry Science Joseph Sturino Ag.& Life Sci Nutrition & Food Science Mariah Hahn Engineering Chemical Engineering Melissa Grunlan Engineering Biomedical Engineering Terry Gentry Ag. & Life Sci Soil & Crop Sciences Tom Wood Engineering Chemical Engineering Wenshe Liu Science Chemistry Zhengdong Chen Engineering Chemical Engineering

The involvement of the new faculty members has definitely enriched the Biotechnology program. Many of these faculty members are serving as Chairs of PPiB student committees, serving on PPiB student committees as well as being involved in collaborative research projects and proposals.

6.3 Faculty Involvement in Teaching Some of the members of the Biotechnology faculty are directly involved in the program by teaching PPiB core courses and/or elective courses. In addition, faculty members are also involved in teaching by their involvement as seminar speakers, and as research supervisors or mentors for BIOT 603. The listing of PPiB courses that have been taught by the Biotechnology faculty is provided in Appendix K. The Chairs of the BIOT graduate student committees, and faculty serving as graduate committee members is shown in Appendix L..

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6.4 Faculty Honors and Recognition Members of the Biotechnology program are outstanding researchers and teachers. They are active in their professional associations, serve on high visibility research and advisory panels, secure highly competitive awards, and are highly sought after as invited speakers in professional meetings and universities all around the world. Table 7: Partial listing of Biotechnology Faculty honors & recognition Faculty Member Honor/Recognition Arul Jayaraman NSF Career Award, 2009

Barbara Gastel John P. McGovern Science and Society Award- Sigma Xi 2010 Christian Hilty NSF Career Award, 2009 Christian Schwarz Student Led Award for Teaching Excellence (SLATE), TAMU 2009

Christie Sayes Empa, nanoEco Young Investigator Award, 2008 Clare Gill Co-lead of TAMU Wide Genomics program, 2009 James Wild Member, DTRA – Science and Technological Advisory Committee, Chemical and Biological Warfare Taskforce 2001- now Jane Welsh Member, Editorial Board, Brain, Behavior and Immunity Joshua Yuan Associate Editor, BMC Research Notes Judith Ball Invited speaker, Am. Soc. Cell Biol Ann. Mtg, Washington D.C, 2007

Mariah Hahn ASEE GSW Young Faculty Award, 2009 Melissa Grunlan NIH R21 grant on Self-Cleaning Sensor Membranes, 2008 Paul de Figueiredo Oak Ridge Associated University Junior Faculty Award, 2007 Penny Riggs Co-lead of TAMU Wide Genomics program, 2009

Rodolfo Amayo Section Editor, PLoS One Ryland Yong Lead on TAMU Wide Phage Biology program Spencer Johnston Invited speaker. International Congress of Entomology, South Africa, 2008 Stephen Safe Distinguished Lifetime Toxicology Scholar Award, Society of Toxicology, 2007 Suresh Pillai Distinguished Lecturer, Institute of Food Technologists, 2008, 2009

Thomas Wood Am. Inst. of Chem. Engineers Bioengineering Plenary Award, 2007

Timothy Cudd Invited speaker, Consortium for Investigation of FASD, NIAAA, Rockville, MD 2008 Victor Ugaz Deputy Editor, Electrophoresis

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7. STRENGTHS AND WEAKNESSES OF THE PROGRAM

The premise of the Professional Program in Biotechnology at Texas A&M University is that the program will offer an attractive alternative to outstanding students who are not interested in the traditional path through graduate school or professional school, but are more interested in industry careers. A key component of the curriculum is the blend of business and biotechnology courses along with a required 10-week internship that is meant to provide the student with a meaningful professional experience. Since summer 2000 when the program officially started, 88 students have graduated with a Masters in Biotechnology (MBIOT) from Texas A&M University. These students are making valuable contributions to the biotechnology industry around the world. In addition to serving the students’ needs, the Graduate Interdisciplinary Faculty of Biotechnology has served as a catalyst in bringing researchers from diverse academic departments across campus to form successful research collaborations. Many of these collaborations may not have otherwise naturally happened. These collaborations which cut across academic departments and colleges have resulted in research grant funding which in turn has provided additional opportunities for graduate and undergraduate student training at Texas A&M University. 7.1 Program Strengths 7.1.1 Faculty Expertise There is an incredible pool of expertise amongst the 63 members of the Biotechnology Faculty at Texas A&M University. The faculty members are successful, self-driven, and dedicated individuals. These are successful researchers who manage strong research programs. The faculty members cover very diverse areas of research with the result that it provides the PPiB students a veritable smorgasbord of research training opportunities.

7.1.2 Curriculum The Biotechnology program at Texas A&M University has a good blend of science courses and business-related courses. Students have the opportunity to focus on a lab- related career or develop the skills needed to make a valued contribution to the non- science related careers in the biotechnology industry. The strong science training of the program enables the graduates of this program to pursue a PhD -based career as well. The required 10-week internship is meant to provide a meaningful professional experience to the students. The feedback received from the different internship locations has been positive in terms of the type of background skills and training the student receives prior to the internship.

7.1.3 Research & Enrichment Opportunities The students have opportunities for hands-on research training in a variety of disciplines that have direct value to their career opportunities and the biotechnology industry. The students have learning opportunities ranging from animal sciences, plant

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sciences, microbiological sciences, process and fermentation engineering, biomedical engineering, clinical studies and technology commercialization. Students are also free to choose the faculty member they want to work with and the research area they want to gain experience. In addition to the research opportunities, the students have a large selection of enrichment activities that they can draw upon for their professional and personal development. The Industry Advisory Council meetings and the Biotechnology Seminar Series are some of the specific enrichment activities targeted directly to the students.

7.1.4 Quality of Incoming Students The program attracts a number of high quality applicants with over 100 applications for the approximately 25 open positions. The quality of incoming graduate students, based on metrics such as GRE scores, TOEFL scores, and GPR, is high. 7.1.5 Biotechnology Industry Involvement There is active involvement of an Industry Advisory Council in the Biotechnology program. The Council made up of members from industry, government and academia assists the program enhancing the curriculum, providing feedback to students and faculty on industry-relevant skills, provides mentoring and networking opportunities for the students. The Advisory Council has also helped foster research collaborations between the Biotechnology program faculty and private industry. 7.1.6 Serving Texas and the Rest of the World The Biotechnology program at Texas A&M University is serving a critical need in terms of human resources to the fledgling biotechnology industry in Texas. According to the Professional Science Masters current estimates, there is only one other institution (University of N. Texas) in this state that offers a Professional Science Masters in Biotechnology. The global growth of biotechnology industry also calls for skilled individuals all around the world. The Biotechnology program provides an outstanding opportunity for students from all around the world to work with world-class faculty and research infrastructure. US-born students who have graduated from this program are currently working in China and Japan providing evidence of the growing relevance of TAMU’s Biotechnology program. 7.2 Program Weaknesses

7.2.1 Program Visibility The program’s visibility both internally and externally is far from satisfactory. Many faculty and students on campus are probably unaware of the existence of this program. Since this is a non-thesis graduate program and the curriculum is fixed, the opportunities for TAMU faculty to interact with the students in the program are limited. This is a relatively new graduate program on campus and thus could also be a reason for the poor visibility. The lack of visibility leads to a number of undesirable outcomes. The program will not come up when the faculty members are advising or mentoring TAMU undergraduate students. The lack of external visibility has serious consequences

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for the program in terms of student recruitment, developing long-term internship and job placement programs with industry, and development activities. The industry collaborators of the faculty are probably unaware of the existence of this program, and so will not look to the program to hire individuals. The hiring of the part-time program coordinator was aimed at improving the program’s internal and external visibility. On-going efforts to improve the program’s visibility have been the development of a new program brochure (Appendix M) , launching a new website (http://ppib.tamu.edu) and having a presence on professional and social networking sites such LinkedIn™ and Facebook™. Additionally, the program coordinator and the Chair have been making presentations in senior undergraduate classes at TAMU to advertise the program to TAMU undergraduates. 7.2.2 Internship and Placement Opportunities Adding to the program’s lack of visibility is the fact that Texas does not have a mature biotechnology industry as compared to the east and west coasts of the United States. This has also limited the program’s ability to develop internship programs with biotechnology companies. The students are responsible for securing internships. However, the hiring of the part-time program coordinator is helping students find internship and job leads. Thus, focused efforts in developing internships and placement programs are still in their infancy. The development of internship programs with selected biotechnology companies is a critical need for the long-term success of this program. The low student satisfaction survey scores stem directly from the challenges the program is facing in terms of securing internships. The planned strategies to enhance industrial internships include inviting companies who have had PPiB interns to join the advisory board and engaging biotech industry HR representatives in Texas and nationwide. In order to assist the students, a student internship-portfolio handbook has been created by the Program Coordinator. Students receive a copy as soon as they join the program at the program orientation (Appendix N). 7.2.3 Domestic Student Enrollment The number of applications and enrollment of US citizen/permanent residents in the program is low. US domestic student enrollment in the Biotechnology program is currently 17%. In Fall 2009, 38% of Masters students at TAMU were international. One reason for the low enrollment in the Biotechnology program could be the direct competition from a non-thesis Masters in Biomedical Sciences offered by the College of Veterinary Medicine that started recently in 2007. Prior to this > 75% of the students in the PPiB program were from the U.S. Another reason could be because the program does not offer a competitive stipend package as compared to other traditional graduate programs. Small to midsize biotechnology companies tend to find the hiring of international students for internships and permanent positions a lot more challenging due to the paperwork and visa procedures. Thus, it is critical that the program enhance the recruitment of US students. A key part of the program’s strategic plan is to actively increase the US student population. The plan aims to increase US domestic student enrollment to 50% .

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7.2.4 Program Funding Funding for the Biotechnology program is provided through the Office of the VPR (for Regents Fellowship funds), the College of Agriculture & Life Sciences, the College of Science and the Instructional Educational Enhancement Funds (IEEF) that is derived from lab fees. The College of Veterinary Medicine is supposed to contribute $ 5000 to the operating expenses but it stopped providing its share almost 3 years ago. It must be mentioned that the College of Veterinary Medicine has started their own new non- thesis Masters in Biomedical Sciences. This funding shortfall affects the program’s ability to carry out its functions and provide essential student services such as field trips, laboratory support, etc. Unlike traditional academic departments which have the “financial cushion” to withstand such budget shortfalls, the impact these shortfalls have on IDPs such as the Biotechnology program is always severe. The program believes that unlike traditional graduate programs, Professional Science Masters programs do require a full-time dedicated Program Coordinator to seek, cultivate, and administer the internship program. A full-time coordinator is critical in maintaining the strong industry linkages that a PSM program requires. Guidelines on how IDPs such Biotechnology program can participate in the university’s development efforts (to identify and engage with philanthropic alumni) is necessary. Such funding sources will be very helpful in developing unique industry speaker based seminar series, equipping teaching laboratories, etc.

7.2.5 Faculty Motivation & Incentive to Participate Faculty who normally work with traditional thesis and dissertation-based graduate students are already fully committed. Therefore, many find no real motivation or incentive to be involved in non-thesis based graduate programs. Since the PPiB students’ time on campus is limited (due to internship obligations), there is less likelihood that these students are really suited to get involved in long-term research projects. So, these students are not competitive or suited to receive research assistantships from participating faculty. Faculty incentives to participate in interdisciplinary teaching activities is another weakness. It is a challenge for some faculty to justify their involvement in IDP program teaching since they are already committed to teaching in their “home” department. One approach to have more faculty involved is to have different “focus areas” such as Bioprocessing, Microbial Diagnostics, Microfluidics, Project Management, Commercialization etc within the current degree program. These focus areas could have customized curricula and could be headed by different faculty. Having such “focus areas” can be useful to students who would like to customize their training in one or more specialized areas. This could incentivize faculty to work with students who have the expertise and interest close to their areas of research interest.

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REFERENCES

Kellogg Commission on the Future of State and Land Grant Universities, 1999. Kellogg Commission Report Returning To Our Roots: The Engaged Institution (3). National Association of State Universities and Land Grant Colleges, Washington, D. C.

National Academy of Sciences Committee on Science, Engineering and Public Policy, 1995. Reshaping the graduate education of scientists and engineers: NAS’s Committee on Science, Engineering and Public Policy Report. Government document (19). U S Government Printing Office. Washington D.C.

Texas Higher Education Coordinating Board, 1993. High tech-high priority. THECB Newsletter. Vol XXVIII Jan/March., Austin, TX.

Texas Science and Technology Council, 1998. Science and Technology Council Report. Texas Science and Technology Council , Austin, TX.

Zey, M., A. Luedke, and S. Murdock, 1999. Changing employment demands and requirements for college graduates: focus group interviews with industry, agency, and school district representatives in Texas. Texas A& M University System, College Station TX .

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LIST OF APPENDICES

Appendix A Faculty of Biotechnology Bylaws

Appendix B Example Advisory Council meeting agenda and overview

Appendix C Biotechnology Program Strategic Plan 2008

Appendix D Recommended course sequence

Appendix E Copy of Biotechnology Society student newsletter

Appendix F List of internship locations

Appendix G List of Biotechnology program graduates

Appendix H 2008-2009 Report of program evaluation & assessment

Appendix I List of Biotechnology program faculty

Appendix J Compiled list of faculty curriculum vitae

Appendix K List of BIOT courses taught by Biotechnology faculty

Appendix L List of committee chairs and members of PPiB graduate student committees

Appendix M Biotechnology program brochure

Appendix N Biotechnology program Internship-Portfolio student handbook

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APPENDICES

APPENDIX A

APPENDIX B 2008 TAMU Biotechnology Program Industry Advisory Council Annual Meeting Agenda

Date: October 24th, 2008 Location: Room 127, College Station Conference Center 1300 George Bush Drive, College Station, Texas (free parking)

9:30 am –9:40 am Introductions ‐ Advisory Council members and faculty

9:40 am – 10: 30 am Biotechnology Program report by Suresh Pillai

10:30 am – 11:30 am Advisory Council feedback

11:30 am‐ 1:30 pm Working Lunch – A sharing of ideas between the Advisory Council, TAMU Administrators, and faculty.

1:30 pm – 1:45 pm Biotech Student Society update

1:45 pm – 3: 00 pm Student perspectives, Q/A from students and feedback from Advisory Council Internship strategies in the current economy Laboratory skills Professional competencies Career options

3:00 pm – 3:15 pm Break

3:15 pm – 3:45 pm Next steps & strategies

3:45 pm Close

12/31/2009

Discussion Topics

Professional Program in Biotechnology • State of the Program

• State of PSM programs nationwide Biotechnology Prog ram Rep ort • Planned Activities

Suresh D. Pillai • Future Outlook • Opportunities Advisory Council Meeting • Challenges October 24, 2008

State of the Program Student Placement

• Student Placement Name Graduation Employer Corey Scherrer 2007 Patent Attorney firm, Japan • Student Enrollment Sabrina Allan 2007 South Texas Law School • Student Internships Poonam Jaiswal 2007 University of Florida Mayur Gadhikar 2007 Dava Oncology LP Ian Miller 2007 UT Medical School, San Antonio Arsalan Safiullah 2007 Applied Biosystems (Ambion)

Better student tracking needed

4

Student Enrollment Student Demographics

50 48 45 41 40 Male 35 32 Female 30 23 25 25 20 Enrolled Students 20 15 2 10 1 5 6 Caucasian 5 Hispanic 37 0 Asian Fall 2000 Fall 2005 Fall 2006 Fall 2007 Fall 2008 African

Median GRE score (V +Q) of Fall 07 class : 1240 Median GRE scores (V+Q) of Fall 08 class (20 students): 1270 Median GPR for Fall 07 class : 3.78 Median GPR for Fall 08 class: 3.85

1 12/31/2009

Student Internships State of PSM Programs Nationwide

• Continues to be a serious challenge • August 2007 – Congress passed the COMPETES Act • Authorizes the NSF to develop and implement a grants program to universities to develop/expand PSM degree programs

• National Academy of Science/National Research Council Report - 2008 • Science Professionals –Master’s education for a competitive world

NRC Report Recommendations NRC Report Recommendations

1. Federal Government 4. Professional Societies a) Federal agencies to fund to start and develop PSM a) Help create and sustain PSM programs programs 5. Higher Education Institutions b) Need-based scholarships for US citizens to enroll in PSM a) Support the development of PSM programs ppgrograms b) PidiProvide incenti tidves and support tffltt for faculty to par tiititicipate in 2. State Governments PSM programs a) Provide funding to expand PSM programs to cater to state c) Should work with employers to create and sustain and regional needs programs 3. Philanthropic Organizations 6. Employers a) Continue to play a role in creating and sustaining innovative a) Participate on advisory councils PSM programs b) Assist with curriculum development, mentoring, student b) Provide matching funds for federal funds projects, internships, employment and financial support

NRC Report Recommendations Planned Activities

™ Students 1. Hiring an Internship/Program Coordinator • Take advantage of internships 9 Identify, recruit, and establish an internship program for the • Involved in industry-sponsored team projects MBIOT students with local, regional, state, national, and • Alumni should be encouraged to provide links for networking international biotechnology companies with current students regarding internships, mentoring 9 Identifyygyp and recruit biotechnology companies to be involved with the biotechnology program in student recruitment and placement 9 develop an aggressive recruitment and retention plan for top quality US domestic students 9 Develop a robust student/alumni tracking database 9 Serve as a link between the biotechnology industry and the TAMU BIOT program

2 12/31/2009

Planned Activities Planned Activities

• Curriculum Enhancement (BIOT 601-602) • Summer Laboratory Intensive BIOT 601-602 program • Course Schedule Adjustment development • To make summers available for internships • Dean’s office has provided specific funding to enhance the laboratory component • Ability to hire faculty specifically to teach these courses • Ability to offer these courses during non-summer semesters

Future Outlook Future Outlook

Challenges Opportunities ƒ Directed internship and placement opportunities 1. Recruiting high caliber students in the face of limited ƒ Bigger pool of qualified US domestic students scholarships ƒ Expanded industry involvement 2. Recruiting qualified US students ƒ Program development for student scholarships, 3. Shrinking? Biotechnology industry in Texas field trips, curriculum enhancement 4. Providing internship and industry oriented project opportunities

CURRENT 2 YEARS 5 YEARS Enrollment Enrollment Enrollment BIOT Advisory Council 46 students 50 students 50 students Domestic: 8 Domestic: 15 Domestic: 35 International: 38 International: 35 International: 15 • Curriculum Enhancement Curriculum Curriculum Curriculum • Continue to provide valuable suggestions for enhancing curriculum Biotech industry relevant Drug Development course Biotechnology specific courses limited GMP/GLP course courses customized for • Serve as a link/resource for Dedicated instructors for the program BIOT 601/602 • Co-ops Online program

• Internships Industry Participation Industry Participation Industry Participation Participation in BIOT Curriculum, student • Industry relevant student team projects Limited to Advisory internships, placement, recruitment, placement, Council • Student Mentoring program development program development • Serve as a mentor to 2 or 3 BIOT students Internships Internships • Program Development Internships Internship slots reserved Internship slots reserved Limited, a big challenge in biotechnology for BIOT students in especially for • Continue to interface with University administrators and others in companies, ~ 25‐30 slots companies around the US international students promoting the program reserved for program and overseas • Assist in securing the financial support and resources needed to Program Development maintain excellence Program Development Secure funding to Program Development Endowments for support scholarships, No specific activities scholarships, seminar student travel , series, student travel curriculum enhancement

3

APPENDIX C CURRENT 2 YEARS 5 YEARS Enrollment Enrollment Enrollment 46 students 50 students 50 students Domestic: 8 Domestic: 15 Domestic: 35 International: 38 International: 35 International: 15

Curriculum Curriculum Curriculum Biotech industry relevant Drug Development course Biotechnology specific courses limited GMP/GLP course courses customized for Dedicated instructors for the program BIOT 601/602 Online program

Industry Participation Industry Participation Industry Participation Participation in BIOT Curriculum, student Limited to Advisory internships, placement, recruitment, placement, Council program development program development

Internships Internships Internships Internship alliances with Internship alliances to Limited, a big challenge 10‐20 local and national include global companies especially for companies for BIOT for BIOT program international students program students students

Program Development Program Development Secure funding to Program Development Endowments for support scholarships, No specific activities scholarships, seminar student travel , series, student travel curriculum enhancement

APPENDIX D Recommended Course Sequence

1st Fall Semester Course Prefix Course Name Credit Hours BIOT 601 Biotechnology Principles and Techniques I 4 BIOT 635 Molecular Biotechnology 3 BIOT 645 Biotechnology Writing 3 BIOT 681 Biotechnology Seminar 1 total 11

Spring Semester Course Prefix Course Name Credit Hours BIOT 602 Biotechnology Principles and Techniques II 4 ACCT 640 Accounting Concepts and Procedures 3 BIOT 603 Applied Principles of Biotechnology 4 OR BIOT 685 Directed Studies* 4 total 11

10 week Summer Session Course Prefix Course Name Credit Hours BIOT 684 Directed Professional Internship 4 FINC 635 Financial Management for Non-Business Majors 3 total 7

2nd Fall Semester Course Prefix Course Name Credit Hours MGMT 655 Survey of Management 3 MKTG 621 Survey of Marketing 3 BIOT 681 Biotechnology Seminar 1 Elective 3 total 10 program total 39

* BIOT 685 may be taken beginning Fall 2010.

APPENDIX E Texas A&M University BT TRANSIT

...FROM SCHOOL TO INDUS TRY

VOLUME 1, ISSUE 3

E D I T O R I A L B O A R D : From the Top

Krishna Develpally Howdy! vive this unstable financial some great pictures of all environment. the fun too! Ashwin Mohan The recent economic downturn has spared no part Further on, Ashwin Featured in the stu- Bhairavi Jani of the industry, including the Mohan talks about the in- dent Spotlight section are biotechnology and pharmaceu- creasing popularity of Pro- Huajun He and Lauralee tical sectors. The cover story fessional Science Master‟s Shanks sharing their re- Riding the Recession Wave programs in the U.S. and search interests, current attempts to review the effect their unique characteristics work and aspirations for the of the recession on the U.S. that set them apart from future. biotech-pharma consortium. It conventional Master‟s pro- includes opinions from indus- grams. We hope you enjoy try experts about what the this edition of BT Tran- recession spells out for fresh In our guest col- sit. As always, comments graduates seeking employ- umn, Funke Owolabi writes and suggestions are most ment, funding scenarios in about her experience at this welcome! INSIDE THIS industry and academia and year‟s „Big Event‟, the most ISSUE: strategies being adopted by cherished community event Thanks and Gig „em! small and large firms to sur- at Texas A&M. We have The Editorial Board Riding the 1 Recession Wave Riding the Recession Wave Jack of All 3 Tejeswini Pisupati & Venkata Mattegunta Trades,

Master of One The landscape of the biotech industry is characterized by numerous start-ups and estab- lished firms. Irrespective of size, these entities depend heavily on long term financing for their Intern Diaries 4 operations because of lengthy drug development cycles and regulatory barriers. Projects are fi- nanced in a periodical fashion with influx of cash ‘Big Events’ at 5 at several stages of development. The industry The Big Event also relies on the monetization of intellectual property- the ability of a firm and its investors to Spotlight 6 capture value from the assets it develops. Throughout the development of the industry, ven- ture capital has played a dominant role in en- couraging innovation and has been the backbone of the industry. www.nicholsoncartoons.com P A G E 2 Riding the Recession Wave...

Start-up firms rely Several estab- cial crisis” says Dr. Salin. heavily on venture capital lished firms are on a as a source of finance. As merger spree, acquiring Food companies the economic crisis deepens, smaller firms in an effort have been under stress more and more venture to combine the innovative due to rising costs of input capitalists are either technology of the new en- but most biotech folks are liquidating invested capital trant with the estab- not working for a food o r f r e e z i n g f u r t h e r lished marketing and dis- company but supplying investment in these firms. tributing channels of its inputs to food production. In spite of high commodity “Small firms are This has left many start-ups own. Other firms, like with cash flows that may RiconPharma, hope to prices in the past few responding to the last less than a year. benefit by providing R&D years, like that of corn services to larger firms. and soy bean, biotech crisis by changing Other sources of Mr. Develpalli says, “Small firms like Monsanto are finance for start-up firms firms are responding to the doing very well. business strategies a r e a l l i a n c e s a n d crisis by changing their We talked to Dr. and partnering with partnerships with estab- business strategies and are Salin about the current lished pharma companies. now partnering with large financial crisis and the job large firms for “As a start-up firm, we de- firms and providing R&D scenario for graduates, pend on big and virtual services”. While the firms and this is what she had providing R&D pharma companies to say, “When for finance,” says services.” you mark total Raj Develpalli, recession and CEO, Ricon- - Raj K. Develpalli its impact, Pharma, a start-up there is a total CEO, RiconPharma firm specializing unemployment in R&D services in figure which is Denville, NJ. steadily rising. U n e m p l o y - L a r g e ment is ex- firms typically p e c t e d t o h a v e s e v e r a l reach 10% be- products in the fore the end of pipeline at differ- this year.” It is ent developmental important to stages. While revenues from are under increasing disaggregate and analyze successfully operating pressure to find new the current economic biologic drugs in the market sources of capital, many situation in order to an- provide the operating have reduced their “The issue of the recession ticipate how it affects the income, additional capital is workforce in order to employment scenario. ought to be separated from raised through equity (for survive the recession. This is because the effect publicly listed firms) and of the recession depends the financial crisis.” debt. “The recession has According to Dr. on the regional economy. affected both small and Victoria Salin, Associate The tendency of recession large firms,” Mr. Develpalli Professor, Department of - Dr. Victoria Salin is to drag down the whole adds. Companies have Agricultural Economics at labor economy. Jobs are Department of responded by terminating Texas A&M University, available, but the market several projects in early there are no big signs that competitiveness has dras- Agricultural Economics, stages of development. New indicate the effect of reces- tically increased, making product pipelines have dried sion on the food and bio- employment even more Texas A&M University up. tech industry. “The issue of difficult. the recession ought to be separated from the finan-

B T T R A N S I T VOLUME 1, ISSUE 3 P A G E 3

Funding at universities may institutions in United States which still keen on investing in University have also taken a hit. When asked if are in the top 5%. This shows that level research. the recession has any impact on re- competition is at its peak. search funding at academic institu- Studies of business models tions, Dr. Jane Welsh, Associate Pro- With economic forecasts indicate that an industry evolves and fessor in the Department of Veteri- indicating a further deepening of adapts during economic stresses, and nary Integrative Biosciences at Texas the crisis by the third or fourth this presents a compelling reason to A&M University says, “I think it is quarter of this year, the immediate be optimistic and hope that a more too early to say. At the moment the future is becoming increasingly vibrant biotech industry is in the government is putting a lot of money bleak for many small firms in the cards. into research.” The NIH usually industry. On the other hand, it funds 15% of the grants it receives. seems like research funding in aca- We thank Mr. Raj Develpalli, Dr. However, in order to receive 15% of demia has been affected at a much Victoria Salin and Dr. Jane funding from the NIH, the institution smaller scale and the government is Welsh for their valuable time and has to be able to compete with other input. Jack of All Trades, Master of One—The Professional Science Master’s Ashwin Mohan

One hundred and thirty pro- grams in 81 institutions extending the includes courses like accounting, grams at eighty institutions and cur- initiative to humanities and social project management, regulatory rently enrolling about 2600 graduate sciences. affairs, innovation and entrepre- students every year, Professional neurship. With guidance from an Science Master‟s (PSM) programs The biosciences industry has advisory committee comprised of have increased both in size and influ- seen a tremendous growth in the last experts from the industry, the cur- ence over the last 10 years. The Pro- 3 to 4 decades. The information gener- riculum is modified based on the fessional Science Master‟s is a unique ated through research led to the de- suggestions and requirements of program designed for students to velopment of innovative products. The the industry. Unlike the usual mas- gain experience in science based emerging biotechnology industry grew ter‟s program with thesis that help skills along with a good understand- at a fast pace with the establishment students specialize in a specific ing of business. This innovative de- and growth of numerous start-ups area of research, the PSM program gree fulfils the aspirations of many every year. This growth created many culminates with either a capstone students who want to possess the opportunities in the fields of research, project or an internship at a right skills to compete in the current product development, business devel- company that enables the stu- fast-paced and dynamic corporate opment, manufacturing, commerciali- dents to relate the concepts learned world. The intense coursework in school, gain experience and prepares them for careers in re- eventually transition to the in- search, law, management, public dustry. policy, etc. Professional Science In 1997, the Alfred P. Master‟s programs are gaining Sloan Foundation started the Pro- attention in academia and the fessional Science Master‟s with industry. The National Research grants to 14 universities for de- Council recommends an expan- veloping programs in sciences and sion of the PSM programs www.sciencemasters.com mathematics. Simultane- throughout the country. Industry- ously, in 2000, the Keck Foundation zation, intellectual property, etc. tailored programs like PSM, with started the Keck Graduate Institute well-established relationships with for training leaders in the biotechnol- Students with Professional companies and increased funding, ogy and healthcare industries. Science Master‟s degrees that blend will be instrumental in creating a Finally, the Council of Graduate research and business are perfect to highly qualified interdisciplinary Schools (CGS) assumed responsibil- assume multiple roles in such compa- workforce that will help fuel and ity and partnered with the Sloan and nies and contribute immensely to the sustain the growth of the economy Ford Foundation and received growth. Most of the PSMs in biosci- for years to come. funding to develop 134 PSM pro- ences have rigorous coursework that P A G E 4 Intern Diaries Deepthi Mikkili From a very young took in Summer ‟08 age I had a propensity helped me fit right for science. Though fasci- in at GSK. This nated by biology, the practi- course taught me cality of engineering at- error coding which tracted me and pursuing helped jumpstart the biotechnology provided a internship. My team perfect balance between s p e c i a l i z e s i n science and engineering. I cardiovascular safety chose PPiB at Texas A&M and I‟m a part of the University because it pre -candidate selec- empowers students to tion process which bridge the gap between the decides if it is worth boardroom and laboratory. investing more in the drug. I employ ECG An internship is a interval analysis to identify An internship is a critical part of the PPiB arrthymias caused by a chance to apply skills learnt program and I was keen on drug. My responsibilities at school to a real-time finding an internship that also include analyzing data work environment and aligned with my interests from cardiovascular studies, broaden our horizon in the “GlaxoSmithKline and career goals. I wanted cardiovascular surgery in field we wish to pursue as a to be part of the rodents and working career. Class presentations, has given me the pharmaceutical industry towards a certification in team projects, hands-on lab opportunity to sur- and it took a lot of oral dosing. Since I also experience and experience perseverance on my part, handle rodents and dogs, as a Teaching Assistant has vey the industry and encouragement from animal handling techniques greatly contributed towards my advisory committee to learnt at school have been boosting my confidence and with a bird’s eye land an offer with an added advantage here. have helped me give GSK GlaxoSmithKline. my very best. view.” GlaxoSmithKline - Deepthi h a s g i v e n m e t he opportunity to survey the industry with a bird‟s eye view. I work for the Safety Assessment Department, which is responsible for making sure the drugs released for clinical trials are safe; the Safety Assessment Department also works with the Product Development Team in analyzing new drug formulations. My time here has been truly enriching and everything has been exciting from the word “GO!”

Applications of Biotechnology, a course I BioHouston Chili Cook-Off - 09

B T T R A N S I T VOLUME 1, ISSUE 3 P A G E 5 ‘Big Events’ at the Big Event Funke Owolabi At 8:30 A.M. on a cold ing a helping hand in yard work, We arrived at the site at 11 Saturday morning, 12,000 Aggies washing and painting. A.M. equipped with hand brushes, gathered at Reed Arena, where rollers, paint, a ladder and two bot- among yells, cheers, and hurrahs, Members of the Biotechnol- tles of Windex. While it was a lot of they listened to former United States ogy Society gathered with other Ag- work and quite messy, too (everyone President George H. W. Bush say, gies at Reed Arena to listen to had paint all over their clothes and “What may keep over 12,000 Aggies speeches by former US President hair), it was a fun-filled experience from their beds on a cold Saturday George H.W. Bush and Texas A&M for all. There were paint and water- morning one might wonder; it is The University President Elsa Murano. hose fights, and it was a bonding time Big Event”. At the end of these speeches, there for the members of the Biotechnology was a yell session which spiked the Society. Everyone found the experi- The Big Event is the largest, excitement in students as they ence of serving the community both one-day student-run community pro- queued to receive their tools for the fulfilling and exhilarating. If you are ject in the nation where students of day‟s job. The TAMU Biotechnology thinking of a way to serve the Bryan- Texas A&M University come to- Society was assigned to the Grace College Station community, sign up gether to say „Thank You‟ to the Baptist Church in Bryan, where it for The Big Event 2010 and experi- residents of Bryan and College had the responsibility for cleaning ence unrivaled fun and fulfillment. Station. For the past 26 years, Ag- windows, painting the outbuilding gies have participated in this annual and other parts of the church. Gig „em!! event to show their appreciation to the surrounding community by giv-

Biotechnology Society members at The Big Event P A G E 6

Huajun He record maintenance. He nancy. He joined the Meth- H u a j u n H e also worked as a Research odist Hospital Research (Howard) joined PPiB in Assistant at Conway Insti- Institute as an intern work- Fall 2007 transitioning from tute of Biomolecular and ing on a project to increase medicine to biotechnology. Biomedical Research, Ire- the understanding of bacte- He completed his B.S. in land, where he was respon- rial physiology for identify- Medicine (equivalent to sible for monitoring AMPK ing new targets for antibac- M.D.) from Wuhan Univer- changes on protein level terial drugs. He also gained sity, Wuhan, China in June and gene expression level expertise in new technolo- 2002 and graduated with a using technique like PCR, gies like transcriptional “I am hard-working, Master‟s degree in Biotech- and training first year profiling to characterize nology this May. medical students in various essential genes and path- self-motivated and a Howard has exten- lab techniques. ways. team player.” sive experience both in the fields of medicine and bio- At Texas A&M Uni- Howard‟s primary technology. He worked as a versity, Howard worked as interest lies in setting up medical intern at Zhongnan a Research Assistant in the collaborative international Hospital and Jingmen No.1 Department of Veterinary business between American Hospital, China, and as a Integrative Biosciences. He and Chinese biotechnology medical assistant at Beau- was involved in a project companies. In his spare mont Hospital, Ireland. related to investigating cel- time, he enjoys swimming, During this period he was lular signaling and signal playing basketball and pho- involved in clinical trials, transduction during preg- tography. patient care and patient LauraLee Shanks LauraLee was al- sistant in the Office of Tech- Texas A&M University Sys- ready a proud Aggie when nology Commercialization, tem. Her work deals with re- she joined the Biotechnol- Texas A&M University Sys- defining pharmaceutical/ ogy program in the Summer tem on business develop- biologics manufacturing by of 2008. She obtained her ment and commercializa- designing facilities based Bachelors in Biochemistry tion services. upon flexible, disposable and Genetics from Texas manufacturing technologies. A&M University, College LauraLee was in- She will be continuing with Station. She is currently in volved in a research project this work as part of her in- “I have high expectations her final semester at Texas related to the use of micro- ternship this Summer. A&M and plans to graduate algae in biodiesel produc- from myself and I am very this August. tion. This involved investi- “I enjoy being in- gating the use of Fourier volved in anything that is motivated to get what I As part of her un- Transform Infrared Spec- science related,” says Laura- dergraduate studies, Laura- troscopy with an Attenu- Lee. She is highly interested want out of my life and Lee was involved in re- ated Total Reflectance ac- in the interface between sci- search related to RNA cessory (FTIR-ATR) for ence and business and is career.” structure and function, monitoring the lipid content looking to pursue a career in RNA repair mechanisms, of algae cultures online in a business development, pro- and freshwater microbiol- commercial-scale produc- ject management, and/or ogy at the Department of tion facility. She is also a technology transfer. Her Biochemistry & Biophysics Graduate Assistant to Dr. hobbies include reading, at Texas A&M. She also Brett Giroir, Vice Chancel- running and hanging out worked as a Graduate As- lor for Research for the with friends.

B T T R A N S I T BioHouston Chili Cook-Off 2009

BT Transit Kleberg Center, Texas A&M University, College Station, TX 77843-2472

Phone: 979-862-4935 Fax: 979-845-1921 E-mail: [email protected]

APPENDIX F Internship Locations for Biotechnology Program students

Company or Institution Location Ambion (now Applied Biosystems/Life Technologies) Austin, TX Aventis Crop Science Tianjin Office Tianjin, China Baylor College of Medicine Houston, TX Baylor College of Medicine- Office of Technology Administration Houston, TX BCR Environmental Jacksonville, FL BioHouston Houston, TX Brigham Women’s Hospital, HPCGG Microarray Cambridge, MA Central Texas Orthopedics Austin, TX DiaSorin, Inc. Stillwater, MN DPS Crime Lab Austin, TX Fort Worth Zoo Fort Worth, TX Geneftix San Diego, CA Genetic Savings & Clone College Station, TX GlaxoSmithKline King of Prussia, PA INCELL San Antonio, TX InforQuest Clinical Network, Inc. Burleson, TX Integrative Center for Homeland Security College Station, TX Lexicon Genetics The Woodlands, TX Lynntech College Station, TX MD Anderson Cancer Research Center Houston, TX Methodist Hospital Houston, TX Monsanto St. Louis, MO New England Biolabs Ipswitch, MA NSF Center for Integrated Pest Management Raleigh, NC Oral Reconstruction and Cosmetic Houston, TX Orchid Cellmark Dallas, TX ProdiGene, Inc College Station, TX Reactive Surfaces Limited Austin, TX Scott & White Memorial Hospital Temple, TX St. Jude Medical Center Alpharetta, GA Synergos, Inc The Woodlands, TX Synthecon Houston, TX TAMU Health Science Center College Station, TX TAMU System Office of Research College Station, TX TAMU System Office of Technology Commercialization College Station, TX TAMU-Biochemistry Dept. College Station, TX TAMU-Food Microbiology Lab College Station, TX TAMU-Food Protein R & D Center College Station, TX TAMU-Institute of Biosciences and Technology Houston, TX TAMU-Integrative Center for Homeland Security College Station, TX TAMU-Laboratory for Plant Genome Technologies College Station, TX TAMU-National Center for Electron Beam Research College Station, TX TAMU-Poultry Science Dept. College Station, TX TAMU-The Veterinary Medical Diagnostic Lab College Station, TX TAMU-Toxicology Lab College Station, TX TAMU-Veterinary Anatomy & Public Health College Station, TX TAMU-Veterinary Physiology and Pharmacology College Station, TX TEEX, Technology & Economic Development Division College Station, TX Texas Agriculture Extension Service College Station, TX Univ. of Southern California-Zilka Neurogenetic Institute Los Angeles, CA Univ. of Kentucky-Center for Pharmaceutical Science & Technology Lexington, KY US Government Accountability Office Washington, D.C. USDA-Cotton Pathology College Station, TX USDA-Forest Service College Station, TX USDA-Southern Plains Agricultural Research Center College Station, TX UT Southwestern Medical Center Dallas, TX

APPENDIX G Biotechnology Program Graduates (since program inception)

2001 Name Kotinek, Sarah McCoy, Jill Shaffer, Alyssandra Souers, Susan Wunderlick, Koryn 2002 Name Cheng, Angie Deshpande, Deepa Dugas, Gena Leonhart, Ryan Mercer, Elinore McClelland Mosteller, Brian Richter, Jennifer Tang,Robert Yeh, David Zeringer, Emily 2003 Name Campbell, Amanda Novak, Tim Shaver, Jaedeanne Galley Steelman, Andrew Whiteley, Sloane 2004 Name Balihe, Michele Boykin, Brad Kundeti, Raji McCreless, Jacob Nguyen, Hongdieu (Heather) Santos, Johnathan Sirsat, Sujata Williams, Suzanne Yu, Timothy Zuniga, JoAnna

2005 Name Al-Swaiti, Iman Blankenhorn, Sarah Kautz, Stephen Montier, Laura Reifschlager, Shani Weber, Thomas 2006 Name Calcote, Joshua Caulk, Lacy Doud, Janel Gopinathan, Ambily Kane, Britteni Landua, John Maan, Mukta Mistry, Rohitkumar Mitchell, Elizabeth Paetzold, Li Thomas, Henry Vuong, Nancy 2007 Name Abernethy, Jason Allan, Sabrina Banda, Harshawardhan Cruz-Vela, Maria Cristina Jaiswal, Poonam Khokhar, Taizoon Lan, Wen-Shiaw Miller, Ian Putuvakkat, Deepa Safiullah, Arsalan Scherrer, Corey Yarlagadda, Annapurna

2008 Name Castaneda-Matson, Miguel Chandrasekaran, Lakshmi Gadhikar, Mayur Green, Bradley Jiang, Yue Kandula, Harikishore Rangachari, Venkat Schlenkar, Lance Stovall, David Vasireddy, Ravikiran 2009 Name Aguillon, Claudia Arora, Srishtee Delgado, Erika He, Huajun Hulsurkar, Mohit Jani, Bhairavi Maheshwari, Mukesh Mikkili, Deepthi Mohan, Ashwin Murthi, Poornima Owolabi, Oluwafunmike (Funke) Pollard, Dylan Sekaran, Harinie Shaik, Shazia Shanks, LauraLee Shen, Yun-An Sivakumar, Kirthiram Vijay Kumar, Sreedevi

APPENDIX H 12/31/2009 Reporting

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Texas A&M University

Detailed Assessment Report 2008-2009 Biotechnology, MBIOT

Mission/Purpose The primary mission of the Professional Biotechnology Program is to train master's level students to be competitive for employment in the biotechnology and affiliated industries. This will be achieved by providing the students a rigorous curriculum that encompasses classroom and laboratory courses in molecular biotechnology, technical writing, management, accounting, finance and marketing. A key component of the curriculum is the blend of business and biotechnology courses along with a required 10-week internship that provides the student a meaningful professional experience.

Goals

G 1: Student recruitment A key goal of the program is to be effective at recruiting high quality graduate students

G 2: Retention Retention of graduate students in the biotechnology program is a key goal of the program

G 3: Industry Involvement The active participation of the biotechnology industry in the biotechnology program is a key goal

G 4: Graduation Ensuring that students graduate from the program within the expected time-frame is a key goal of the program

G 5: Internship Placement Enabling students to secure professional internship opportunities is a key goal

G 6: Job Placement Enabling students to find full-time jobs within the biotechnology industry

Student Learning Outcomes, with Any Associations and Related Measures, Achievement Targets, Findings, and Action Plans

O 1: Basic knowledge of Biotechnology Graduates will be able to demonstrate a basic knowledge of biotechnology http://app.weaveonline.com/report.aspx 1/5 12/31/2009 Reporting Associations: General Education or Core Curriculum: 1 Master the depth of knowledge required of a discipline

Related Measures:

M 1: Performance in academic core courses Students should maintain a GPR of 3.0 or better Source of Evidence: Performance (recital, exhibit, science project) Achievement Target: 80% of students will obtain either an A or a B grade in the BIOT courses

M 2: Internship Evaluation The internship site supervisor provides a mid-term and final evaluation of the students' performance during the internship Source of Evidence: Field work, internship, or teaching evaluation

M 3: Professional Portfolio Students will complete a Professional Portfolio that encompasses their reflections on the academic courses and competencies and their internship experience Source of Evidence: Portfolio, showing skill development or best work

M 4: Final Examination Students will complete a final examination that will be conducted by their graduate committee Source of Evidence: Comprehensive/end-of-program subject matter exam

O 2: Ability of perform specific laboratory protocols Students will be able to demonstrate specific laboratory protocols that involve DNA and protein manipulations Associations: General Education or Core Curriculum: 1 Master the depth of knowledge required of a discipline

Related Measures:

M 1: Performance in academic core courses Students should maintain a GPR of 3.0 or better Source of Evidence: Performance (recital, exhibit, science project) Achievement Target: 80% of students should obtain either an A or a B grade in BIOT 601 and BIOT 602

M 2: Internship Evaluation The internship site supervisor provides a mid-term and final evaluation of the students' performance during the internship Source of Evidence: Field work, internship, or teaching evaluation

M 3: Professional Portfolio Students will complete a Professional Portfolio that encompasses their reflections on the academic courses and competencies and their internship experience Source of Evidence: Portfolio, showing skill development or best work http://app.weaveonline.com/report.aspx 2/5 12/31/2009 Reporting M 4: Final Examination Students will complete a final examination that will be conducted by their graduate committee Source of Evidence: Comprehensive/end-of-program subject matter exam

O 3: Basic knowledge of Business principles Students should be able to demonstrate an understanding of basic business principles

Related Measures:

M 1: Performance in academic core courses Students should maintain a GPR of 3.0 or better Source of Evidence: Performance (recital, exhibit, science project) Achievement Target: 80% of students will obtain either an A or B in their business courses

M 3: Professional Portfolio Students will complete a Professional Portfolio that encompasses their reflections on the academic courses and competencies and their internship experience Source of Evidence: Portfolio, showing skill development or best work

M 4: Final Examination Students will complete a final examination that will be conducted by their graduate committee Source of Evidence: Comprehensive/end-of-program subject matter exam

O 4: Problem-solving skills Students will demonstrate critical thinking and creative problem solving skills Associations: General Education or Core Curriculum: 2 Demonstrate critical analysis skills

Related Measures:

M 1: Performance in academic core courses Students should maintain a GPR of 3.0 or better Source of Evidence: Performance (recital, exhibit, science project)

M 2: Internship Evaluation The internship site supervisor provides a mid-term and final evaluation of the students' performance during the internship Source of Evidence: Field work, internship, or teaching evaluation

M 3: Professional Portfolio Students will complete a Professional Portfolio that encompasses their reflections on the academic courses and competencies and their internship experience Source of Evidence: Portfolio, showing skill development or best work

M 4: Final Examination Students will complete a final examination that will be conducted by their graduate committee Source of Evidence: Comprehensive/end-of-program subject matter exam http://app.weaveonline.com/report.aspx 3/5 12/31/2009 Reporting

O 5: Teamwork skills Students will demonstrate the ability to work in a multidisciplinary team Associations: General Education or Core Curriculum: 4 Provide ethical leadership in a global and diverse society

Related Measures:

M 1: Performance in academic core courses Students should maintain a GPR of 3.0 or better Source of Evidence: Performance (recital, exhibit, science project)

M 2: Internship Evaluation The internship site supervisor provides a mid-term and final evaluation of the students' performance during the internship Source of Evidence: Field work, internship, or teaching evaluation

M 3: Professional Portfolio Students will complete a Professional Portfolio that encompasses their reflections on the academic courses and competencies and their internship experience Source of Evidence: Portfolio, showing skill development or best work

M 4: Final Examination Students will complete a final examination that will be conducted by their graduate committee Source of Evidence: Comprehensive/end-of-program subject matter exam

O 6: Communication skills Students should demonstrate an ability to make effective presentations. Students should be proficient in writing and speaking Associations: General Education or Core Curriculum: 3 Communicate effectively in writing and speaking

Related Measures:

M 1: Performance in academic core courses Students should maintain a GPR of 3.0 or better Source of Evidence: Performance (recital, exhibit, science project)

M 2: Internship Evaluation The internship site supervisor provides a mid-term and final evaluation of the students' performance during the internship Source of Evidence: Field work, internship, or teaching evaluation

M 3: Professional Portfolio Students will complete a Professional Portfolio that encompasses their reflections on the academic courses and competencies and their internship experience Source of Evidence: Portfolio, showing skill development or best work

M 4: Final Examination Students will complete a final examination that will be conducted by their http://app.weaveonline.com/report.aspx 4/5 12/31/2009 Reporting graduate committee Source of Evidence: Comprehensive/end-of-program subject matter exam

O 7: Bioethics The students should demonstrate basic understanding of bioethics and understand how these issues could affect them in their professional careers

Related Measures:

M 1: Performance in academic core courses Students should maintain a GPR of 3.0 or better Source of Evidence: Performance (recital, exhibit, science project)

M 2: Internship Evaluation The internship site supervisor provides a mid-term and final evaluation of the students' performance during the internship Source of Evidence: Field work, internship, or teaching evaluation

M 3: Professional Portfolio Students will complete a Professional Portfolio that encompasses their reflections on the academic courses and competencies and their internship experience Source of Evidence: Portfolio, showing skill development or best work

http://app.weaveonline.com/report.aspx 5/5

APPENDIX I LIST OF BIOTECHNOLOGY PROGRAM FACULTY AND ASSOCIATED ACADEMIC COLLEGES

Name College Berghman, Luc Agriculture & Life Sciences Chapkin, Robert Agriculture & Life Sciences Coates, Craig Agriculture & Life Sciences Defigueiredo, Paul Agriculture& Life Sciences Funkhouser, Ed Agriculture& Life Sciences Gentry, Terry Agriculture & Life Sciences Gill, Clare Agriculture & Life Sciences Gould, Jean Agriculture & Life Sciences Gunn, Martyn Agriculture & Life Sciences Ing, Nancy Agriculture & Life Sciences Johnston, Spencer Agriculture & Life Sciences Loopstra, Carol Agriculture & Life Sciences Magill, Clint Agriculture & Life Sciences Mullet, John Agriculture & Life Sciences Ng, Desmond Agriculture & Life Sciences Park, Bill Agriculture & Life Sciences Pillai, Suresh Agriculture & Life Sciences Rathore, Keerthi Agriculture & Life Sciences Stelly, David Agriculture & Life Sciences Sturino, Joseph Agriculture & Life Sciences Wild, Jim Agriculture & Life Sciences Yuan, Joshua Agriculture & Life Sciences Zhang, Hongbin Agriculture & Life Sciences Zhou, Huaijun Agriculture & Life Sciences

Name College Cheng, Zhengdong Dwight Look College of Engineering Grunlan, Melissa Dwight Look College of Engineering Hahn, Mariah Dwight Look College of Engineering Han, Arum Dwight Look College of Engineering Jayaraman, Arul Dwight Look College of Engineering Kao, Katy Dwight Look College of Engineering Nikolov, Zivko Dwight Look College of Engineering Schwartz, Cris Dwight Look College of Engineering Ugaz, Victor Dwight Look College of Engineering Wood, Thomas Dwight Look College of Engineering

Name College Blackwell, David Mays School of Business Buenger, Victoria Mays School of Business Name College Aramayo, Rodolfo College of Science Hall, Tim College of Science Hilty, Christian College of Science Liu, Wenshe College of Science Patterson, C.O College of Science Russell, David College of Science Siegele, Deborah College of Science Thomas, Terry College of Science

Name Other Alaniz, Robert TAMU Health Science Center Samuel, James TAMUHSC Health Science Center Cornwell, Brett Office of Technology Commercialization Faridi, Nurul USDA-Forest Service

Name College Ball, Judy College of Veterinary Medicine & Biomedical Sciences Burghardt, Robert College of Veterinary Medicine & Biomedical Sciences Cothran, Gus College of Veterinary Medicine & Biomedical Sciences Cudd, Timothy College of Veterinary Medicine & Biomedical Sciences Derr, James College of Veterinary Medicine & Biomedical Sciences Dunne, Patrick College of Veterinary Medicine & Biomedical Sciences Gastel, Barbara College of Veterinary Medicine & Biomedical Sciences Parr, Rebecca College of Veterinary Medicine & Biomedical Sciences Safe, Stephen College of Veterinary Medicine & Biomedical Sciences Sayes, Christie College of Veterinary Medicine & Biomedical Sciences Skow, Loren College of Veterinary Medicine & Biomedical Sciences Tiffany-Castiglioni, Evelyn College of Veterinary Medicine & Biomedical Sciences Welsh, Jane College of Veterinary Medicine & Biomedical Sciences Young, Colin College of Veterinary Medicine & Biomedical Sciences

APPENDIX J BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Alaniz, Robert Christopher Assistant Professor, Microbial and Molecular eRA COMMONS USER NAME (credential, e.g., agency login) Pathogenesis, College of Medicine, Texas A&M ALANIZR University Health Science Center EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) Texas A&M University B.S. 1991 Microbiology University of Washington - Seattle Ph.D. 2002 Immunology University of Washington - Seattle Post-Doc 2007 Microbial Pathogenesis

A. Positions and Honors. PROFESSIONAL EXPERIENCE AND ACADEMIC APPOINTMENTS: 1991-1995 Research Associate, Texas Center for Infectious Disease, San Antonio, TX 1995-2002 Graduate Research Assistant, Department of Immunology, University of Washington 2002-2007 Post-Doctoral Fellow, Department of Laboratory Medicine, University of Washington 2008-present Assistant Professor, Department of Microbial and Molecular Pathogenesis, Texas A&M Health Science Center 2008-present Member, Graduate Faculty, Graduate School of Biomedical Sciences, Texas A&M Health Science Center 2008-present Member, Graduate Faculty, Division of Research and Graduate Studies, Texas A&M University 2008-present Director, Cell Analysis Facility, College of Medicine, Texas A&M Health Science Center 2009-present Member, Graduate Faculty, Professional Program in Biotechnology, Texas A&M University

AWARDS AND HONORS: 1996-1997 National Institutes of Health Immunology Training Grant 1997-2002 National Institutes of Health Minority Pre-Doctoral Fellowship Stipend 1998 Travel Award, Department of Immunology, University of Washington, for American Association of Immunologists Conference, San Francisco, California 2000 Travel Award, Sandra E. Clark Fund, University of Washington, for International Innate Immunity Conference, Santorini, Greece 2002-2007 Senior Research Fellowship, Department of Laboratory Medicine, University of Washington 2009 Distinguished Alumnus Award, PREP Engineering Program, University of Texas at San Antonio

PROFESSIONAL ORGANIZATIONS: 1997-present Member, Society for the Advancement of Chicanos and Native Americans in Science (SACNAS) 1998-present Member, American Society for Microbiology (ASM) 2008-present Member, American Association of Immunologists (AAI) 2008-present Member, International Society for Analytical Cytometry (ISAC)

B. Selected peer-reviewed publications (in chronological order). Alaniz RC, Deatherage BL, Lara JC, and Cookson BT. Membrane vesicles are immunogenic facsimiles of Salmonella typhimurium that potently activate dendritic cells, prime B- and T-cell responses, and stimulate protective immunity in vivo. Journal of Immunology. 179:7692 (2007). Alaniz RC, Cummings LA, Bergman MA, Rassoulian-Barrett SL, and Cookson BT. Salmonella typhimurium coordinately regulates FliC location and reduces dendritic cell activation and antigen presentation to CD4+ T cells. Journal of Immunology. 177:3983-93 (2006). Bergman MA, Cummings LA, Alaniz RC, Mayeda L, Fellnerova I, and Cookson BT. CD4+ T-cell responses generated during murine Salmonella enterica serovar Typhimurium infection are directed towards multiple epitopes within the natural antigen FliC. Infection and Immunity. 73:7226-35 (2005). Alaniz RC, Sandall S, Thomas EK, and Wilson CB. Increased dendritic cell numbers impair protective immunity to intracellular bacteria despite augmenting antigen-specific CD8+ T lymphocyte responses. Journal of Immunology. 172:3725-35 (2004). Alaniz RC, Thomas SA, Perez-Melgosa M, Mueller K, Farr AG, Palmiter RD, and Wilson CB. Dopamine β–hydroxylase deficiency impairs cellular immunity. Proceedings of the National Academy of Science. 96:2274 – 2278 (1999).

C. Research Support. CURRENT 1) TAMHSC (Alaniz) 02/01/08-01/31/11 Intramural TAMHSC Faculty Startup Funding Pathogen-specific T-cell Development during Mucosal Salmonella infection PENDING 1) Senior Research Award (Alaniz) 2009 Crohn’s and Colitis Foundation Humanized Mouse Model of Inflammatory Bowel Disease and Microbial Immunity Role: Principal Investigator 2) CA129444 (Chapkin) 2009 – 2011 NIH/NCI Gene expression analysis of coding and non-coding RNAs in colon cancer prevention Role: Collaborator 3) Instrumentation Grant (Ficht) 2009 NIH FACSAria II Cytometer/Sorter for Biosafety Level III Facility at TAMU Role: Main User and Technical Expert Program Director/Principal Investigator (Last, First, Middle):

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Rodolfo Aramayo Associate Professor eRA COMMONS USER NAME (credential, e.g., agency login) raramay EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) University of Brasília Department of Cellular Biology. Brasília, D. F., BSc 1982 Molecular Biology Brazil University of Brasília Department of Cellular Biology. Brasília, D. F., MSc 1986 Molecular Biology Brazil University of Georgia PhD 1992 Genetics Department of Genetics. Athens, Georgia, USA

A. Positions and Honors.

POST-DOCTORAL TRAINING TITLE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY Research Assistant University of Wisconsin 1992- Genetics Department of Biomolecular Chemistry. Madison, 1993 Wisconsin, USA Supervisor: Dr. Robert L. Metzenberg Assistant Researcher 1993- 1996 Genetics Basic Life Science Stanford University 1996- Genetics Research Associate Department of Biological Sciences. Stanford, 1997 California, USA Supervisor: Dr. Robert L. Metzenberg

ACADEMIC/RESEARCH POSITIONS TITLE INSTITUTION AND LOCATION YEAR(s) Researcher II Department of Genetic Engineering 1983-1986 National Center for Genetic Resources and Biotechnology (CENARGEN- EMBRAPA). Brasília, D. F., Brazil Assistant Department of Biology 1997-2004 Professor Texas A&M University. College Station, Texas, USA Associate Department of Biology 2004- Professor Texas A&M University. College Station, Texas, USA present

HONORS/AWARDS AWARDING INSTITUTION YEAR(s) Pre-doctoral Brazilian Enterprise for Agricultural Research (EMBRAPA). Brasília, D. 1982-1983 Traineeship F., Brazil Master Research Brazilian Enterprise for Agricultural Research (EMBRAPA). Brasília, D. 1983-1984 Fellowship F., Brazil Doctoral Fellowship Brazilian Enterprise for Agricultural Research (EMBRAPA). Brasília, D. 1987-1988 F., Brazil Doctoral Fellowship Brazilian National Council for Scientific and Technological 1989-1990 PHS 398/2590 (Rev. 11/07) Page Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): PI Name

HONORS/AWARDS AWARDING INSTITUTION YEAR(s) Development (CNPq). Brasília, D. F., Brazil Research Department of Genetics. University of Georgia. Athens, Georgia, USA 1991-1992 Assistantship Selected fellow for the The National Academy of Sciences. The National Academies. Irvine, 2004-2005 Beckman Frontiers of California, USA Science Symposium Section Editor Public Library of Science One (PLoS ONE) 2009- Genetics and http://www.plos.org/ present Genomics

B. Selected peer-reviewed publications (in chronological order). 3. Aramayo R, Adams TH, Timberlake WE (1989) A large cluster of highly expressed genes is dispensable for growth and development in Aspergillus nidulans. Genetics 122: 65-71. 6. Aramayo R, Metzenberg RL (1996) Meiotic transvection in fungi. Cell 86: 103-113. 8. Aramayo R, Peleg Y, Addison R, Metzenberg R (1996) Asm-1+, a Neurospora crassa gene related to transcriptional regulators of fungal development. Genetics 144: 991-1003. 16. Galagan JE, Calvo SE, Borkovich KA, Selker EU, Read ND, et al. (2003) The genome sequence of the filamentous fungus Neurospora crassa. Nature 422: 859-868. 22. Lee DW, Pratt RJ, McLaughlin M, Aramayo R (2003) An argonaute-like protein is required for meiotic silencing. Genetics 164: 821-828. 25. Freitag M, Lee DW, Kothe GO, Pratt RJ, Aramayo R, et al. (2004) DNA methylation is independent of RNA interference in Neurospora. Science 304: 1939. 26. Lee DW, Seong K-Y, Pratt RJ, Baker K, Aramayo R (2004) Properties of Unpaired DNA Required For Efficient Silencing in Neurospora crassa. Genetics 167: 131-150. 28. Kelly WG, Aramayo R (2007) Meiotic silencing and the epigenetics of sex. Chromosome Res 15: 633-651. 30. Hu JC, Aramayo R, Bolser D, Conway T, Elsik CG, et al. (2008) The emerging world of wikis. Science 320: 1289- 1290. 31. Lee DW, Freitag M, Selker EU, Aramayo R (2008) A cytosine methyltransferase homologue is essential for sexual development in Aspergillus nidulans. PLoS ONE 3: e2531.

C. Research Support.

RESEARCH SUPPORT SOURCE: National Institutes of Health STUDY SECTION: Genetics TITLE: Genetics and Molecular Study of Meiotic Trans-sensing and Meiotic Silencing PRINCIPAL INVESTIGATOR: Dr. Rodolfo Aramayo NUMBER: R01-GM58770 PERIOD: 01/01/1999 to 12/31/2009

PHS 398/2590 (Rev. 11/07) Page Continuation Format Page BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Judith M. Ball Associate Professor eRA COMMONS USER NAME Jball EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) Southeaster Louisiana University, Hammond, LA B.S. 1974 Med. Tech and Chem. Louisiana State University, Baton Rouge, LA Ph.D. 1990 Biochemistry Univ. of Pittsburgh School of Medicine, Postdoc 1990-1992 Biochemistry Pittsburgh, PA Univ of Alabama at Birmingham, Birmingham, AL Postdoc 1992-1994 Virology / Cell Biology Baylor College of Medicine, Houston, TX Res Asso 1994-1997 Virology A. Positions and Honors Positions and Employment 1997 - 2002: Assistant Professor, Dept. of Pathobiology, Texas A&M University, College Station, TX. 1997 – Present Graduate Faculty Member, Texas A&M University 1997 – Present Director, Peptide Synthesis Core Facility, Texas A&M University. 1998 - 2002: Assistant Professor, Joint appointment, Dept. of Molecular and Cellular Medicine, Texas Health Science Center, Texas A&M University, College Station, TX. 2000 – Present: Full member and officer, Interdisciplinary Faculty of Virology, Texas A&M University, College Station, TX. 2001 – Present: Full member, Interdisciplinary Faculty of Toxicology, Texas A&M University, College Station, TX. 2002 – Present Associate Professor with tenure, Dept. of Pathobiology, Texas A&M University, College Station, TX. 2002 – Present Associate Professor, Joint appointment, Dept. of Molecular and Cellular Medicine, Texas Health Science Center, Texas A&M University, College Station, TX. 2002 – Present Faculty of Biotechnology, member and executive committee 2003 – 2006 Graduate Advisor, Department of Pathobiology, Texas A&M University, College Station, TX. 2003 – Present Member, Center for Microencapsulation & Drug Delivery, Texas A&M University. 2005 – 2007 Member, Center for Environmental and Rural Health, Texas A&M University. Other Experience and Acknowledgements 1996 - Invited keynote speaker, Sixth Annual Graduate Student Symposium, Department of Biochemistry, LSU. 1997 - Recipient of the Dr. Chris Noonan Award, Division of Molecular Virology, Baylor College of Medicine. 1997 - Invited speaker, 6th International Meeting of dsRNA Viruses, Mexico. 1999 - Elected, University Council of Principle Investigators, Texas A&M University, College Station, TX. 1998, 2003, 2004 National Initiative Competitive Grants Program, CREES, USDA, Animal Protection, Panel A / B. 2001 Office of Scientific Quality Control Panel, USDA, ARS, NP103 Animal Health – Virology and Prion Disease. 2005 & 2006 Panel Manager, National Initiative Competitive Grants Program, CREES, USDA, Animal Protection 2005 Invited speaker Therapeutics for Enteric Diseases, NIH, Bethesda, MD 2005 Invited speaker, Texas-United Kingdom Collaborative Research Initiative on Emerging Infections, GalvestonTX 2007 Invited speaker, American Society of Cell Biology 47th Annual Meeting, Washington D.C. B. Selected peer-reviewed publications Parr, R. D., S. M. Storey, D. M. Mitchell, A. L. McIntosh, M. Zhou, K. D. Mir, and Ball, J.M. (2006). The rotavirus enterotoxin, NSP4, directly interacts with the caveolae structural protein, caveolin-1. J. Virol. 80:2842-54. Gallegos, A.M., Storey, S.M., Kier, A.B., Schroeder, F., and Ball, J.M. (2006). Structure and cholesterol dynamics of caveolae/raft and non-raft plasma membrane domains. Biochem 45: 12100-12116. Schroeder, F., Atshaves, B.P., McIntosh, A.L., Gallegos, A.M., Storey, S.S., Parr, R.D., Jefferson, J.R., Ball, J.M., Kier, A.B. (2007) Sterol carrier protein-2: New roles in regulating lipid rafts and signaling. Biochemica et Biophysica Acta 1771:700-718. Mir, K. Parr, R.D., Schroeder, F., and Ball, J.M. (2007). Rotavirus NSP4 Binds Both the Amino- and Carboxyl- Termini of Caveolin-1.Virus Research 126:106-11 Storey, S.M., Schroeder, F., and Ball, J.M. (2007). Full-length, glycosylated NSP4 is localized to plasma membrane caveolae by a novel raft isolation technique. J. Virol. 81:5472-5483. Parr, R.A., Martin, G., Schroeder, M., Kier, A., Schroeder, F., and Ball, J.M. (2007). A new N-terminal Recognition Domain in Caveolin-1 Interacts with Sterol Carrier Protein-2 (SCP-2). Biochem 46:8301-8314 Storey, S.M., Gallegos, A.M., Atshaves, B.P., McIntosh, A.L., Martin, G.G., Parr, R.D., Landrock, K., Kier, A.B., Ball, J.M., and Schroeder, F. (2007). Selective cholesterol dynamics between lipoproteins and caveolae/lipid rafts. Biochem. 46:13891-13906. Gallegos, A.M., Atshaves, B.P., McIntosh, A.L., Storey, S.M., Ball, J.M., Kier, A.B., and Schroeder, F. (2008). Membrane Domain Distributions: Analysis of Fluorescence Sterol Exchange Kinetics. Current Analytical Chem., 4:1-7. Martin, G.G., Hostetler, H.A., Tichy, S.E., Russell, D.H., Berg, J.M., Woldegiorgis, G., Spencer, T.A., Ball, J.M., Kier, A.B., and Schroeder, F. (2008) Structure and function of the sterol carrier protein-2 (SCP-2) N-terminal pre-sequence. Biochem. 47:5915-5934. Parr, R.D., Williams, C.V., Schroeder, M.E., and Ball, J.M. (2009) T hydrophobic residues of the rotavirus NSP4 are sufficient to bind caveolin-1. Submitted Gibbons, T.F., Storey, S.M., Williams, C.V., Schroeder, M., Schroeder, F., and Ball, J.M. (2009) Full-length, fully-glycosylated rotavirus NSP4 is exposed on the plasma membrane exofacial surface and released from rotavirus-infected cells. In preparation.

C. Research Support (past 2 years)

USDA Cooperative State Research, Education, and Extension Service (CREES), Formula Health and Disease (PI: Parr) 11/2007 – 11/2009 “Differentially Regulated Tissue-Specific Genes between Virulent and Avirulent Bovine Rotavirus”. This study will distinguish virulent vs. avirulent bovine rotavirus sequences that regulate tissue-specific genetic responses. The focus of this study is bovine RV infections and how these infections differentially regulate There is no overlap with the current proposal. Role: Co-Investigator

USDA Cooperative State Research, Education, and Extension Service (CREES), Formula Health and Disease (PI: Edwards) 11/2007 – 11/2009 “Determination of the Target Cell(s) and Infection Sequence of Cache Valley Virus in the Ovine Fetus”. The overall goal of this study is to establish the mechanism of arthrogryposis in the ovine fetus infected with Cache Valley virus. We proposed to prove the following theory: infection of the amniotic and chorioallantoic membranes disrupts fetal fluid balance via interruption of the ‘intramembranous’ pathway resulting in stunted fetal growth and malformations. There is no overlap with the current proposal. Role: Co-Investigator

Internal Grant, Texas A&M University (PI:Ball) 1/01/09 – 8/31/09 “Identification of therapeutic targets in a newly developed pathogenesis model of rotavirus NSP4”. The objective of this application is to explore the interactions of the rotavirus enterotoxin, NSP4, with host cell molecules to indentify targets for effective therapeutic strategies to block enterotoxin-induced diarrhea. There is no overlap with the current proposal other than techniques. Role: PI

Pittsburgh Center for HIV Protein Interactions, NIH, Collaboration Development Pilot Program (PI: Ball) 11/1/09 – 11/1/10 “Discernment of HIV core protein interactions with select host-cell proteins by yeast three hybrid analyses”. The goal of this study is to identify key interacting molecules that facilitate transport of HIV core particles early post infection.

Luc R. Berghman

Assistant Professor Dept. of Poultry Science Texas A&M University College Station, Texas

EDUCATION

Postdoc - University of Leuven, Belgium, Zoology, 1988-1994 Ph.D. - University of Leuven, Belgium, Zoology, 1982-1988 M.Sc. - University of Leuven, Belgium, Zoology, 1980-1982 B.Sc. - University of Leuven, Belgium, Biology, 1978-1980

POSITIONS AND HONORS

1988 - Postdoctoral Research Fellow, National Fund for Scientific Research, Belgium 1994 - Senior Research Associate, National Fund for Scientific Research, Belgium 1994 - Assistant Professor, Department of Zoology, University of Leuven (partim) 06/1998 – present: Assistant Professor, Department of Poultry Science, TAMU 09/1998 – present: Assistant Professor, Department of Veterinary Pathobiology, TAMU (joint appointment)

PROFESSIONAL ACTIVITIES

Poultry Science Journal (associate editor) The Histochemical Journal (ad hoc) Biology of Reproduction (ad hoc) Comparative Biochemistry and Physiology (ad hoc) Fund for Scientific Research (FWO) Flanders, Belgium (ad hoc) USDA NRICGP Animal Reproductive Efficiency Program (ad hoc) NSF Integrative Animal Biology (ad hoc)

REFEREED JOURNAL ARTICLES One step purification of chicken growth hormone from a crude pituitary extract by use of a monoclonal immunoadsorbent. Berghman, L.R., Van Beeumen, J., Decuypere, E., Kühn, E.R. and Vandesande, F. (1988). Journal of Endocrinology 118, 381-387. Immunocytochemical demonstration of chicken hypophyseal thyrotropes and development of a radioimmunological indicator for chicken TSH using monoclonal and polyclonal homologous antibodies in a subtractive strategy. Berghman, L.R., Darras, V.M., Chiasson, R.B., Decuypere, E., Kühn, E.R., Buyse, J. and Vandesande, F. (1993). General and Comparative Endocrinology 92, 189-200. A simple method for the immunocytochemical processing of large numbers of floating cryosections, applied to the screening for monoclonal antibodies. Berghman, L.R., Grauwels, L., Vanhamme, L. and F. Vandesande (1994). Journal of Immunological Methods 168(2): 197-202. Interactions between adenohypophyseal, hypothalamic and nasal presumptive territories during early neurulation process. Elamraoui, A ., Berghman, L.R. & Dubois, P.M. (1995). Endocrine 3: 335-343. Effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on cAMP formation and growth hormone release from chicken anterior pituitary cells. Peeters K, Langouche L, Vandesande F, Darras VM, Berghman LR (1998) Ann N Y Acad Sci 865:471-474. The effect of food intake from 2 to 24 weeks of age on LHRH-I content in the median eminence and gonadotrophin levels in pituitary and plasma in female broiler breeder chickens. Bruggeman V, D'Hondt E, Berghman L, Onagbesan O, Vanmontfort D, Vandesande F, Decuypere E (1998) Gen Comp Endocrinol. 112(2):200-209. Pre- and posthatch developmental changes in hypothalamic thyrotropin-releasing hormone and somatostatin concentrations and in circulating growth hormone and thyrotropin levels in the chicken. Geris, K.L., Berghman, L.R., Kuhn, E.R. and Darras, V.M. (1998) J. Endocrinol. 159: 219-225. Characterisation of chicken monocytes, macrophages and interdigitating cells by the monoclonal antibody KUL01. Mast J, Goddeeris BM, Peeters K, Vandesande F, Berghman LR (1998) Vet Immunol Immunopathol Feb 27;61(2-4):343-357. The molecular characterization of chicken pituitary N-terminal pro-opiomelanocortin (POMC): affinity isolation of the isoforms and cloning of the POMC cDNA. Berghman, L.R., Devreese, B., Verhaert, P., Gerets, H., Arckens, L., Vanden Broeck, J., van Beeumen, J., Vaudry, H. and Vandesande, F. (1998) Mol Cell Endocrinol 25: 119-130 Comparative distribution of pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal polypeptide immunoreactivity in the chicken forebrain. Peeters K, Berghman LR, Vandesande F (1998). Ann N Y Acad Sci May 15;839:417-419. The drop in plasma thyrotropin concentrations in fasted chickens is caused by an action at the level of the hypothalamus: role of corticosterone. Geris, K., Berghman, L.R., Kuhn, E.R. and Darras, V.M. (1999). Domest Anim Endocrinol. 16(4):231-237. Prenatal development of hematopoietic and hormone-producing cells in the chicken adenohypophysis. Allaerts, W., Boonstra-Blom, A.G., Peeters, K., Janse, E.M., Berghman, L.R. and Jeurissen, S.H.M. (1999). Gen. Comp. Endocrinol. 114: 213-224. Immunohistochemical evidence that follicle-stimulating hormone and luteinizing hormone reside in separate cells in the chicken pituitary. Proudman, J. A., Vandesande, F. and Berghman, L. R. (1999). Biology of Reproduction 60: 1324-1328. Effects of timing and duration of feed restriction during rearing on reproductive characteristics in broiler breeder females. Bruggeman, V., Onagbesan, O., D'Hondt, E., Buys, N., Safi, M. Vanmontfort, D., Berghman, L., Vandesande, F. and Decuypere, E. (1999). Poultry science 78: 1424-1434. Validation of a new antiserum directed towards the synthetic c-terminus of the fos protein in avian species: immunological, physiological and behavioral evidence. D'Hondt, E., Vermeiren, J., Peeters K., Balthazart J., Tlemçani O., Ball G. F., Duffy D. L., Vandesande F. and Berghman L. (1999). J Neurosci Methods 91: 31-45. The sequence and distribution of pro-opiomelanocortin (POMC) in the pituitary and the brain of the chicken (Gallus gallus) Gerets, H., Peeters, K., Vandesande, F. and Berghman, L.R. (2000). Journal of Comparitive Neurology 417; 250-262. Colocalization of arginine-vasotocin and chicken luteinizing hormone-releasing hormone-I (cLHRH-I) in the preoptic-hypothalamic region of the chicken. D’Hondt, E., Eelen, M., Berghman, L. and F. Vandesande (2000). Brain Research 856(1-2): 55-67. Adrenal inhibition of corticotropin-releasing hormone-induced thyrotropin release: a comparative study in pre- and posthatch chicks. Geris KL, Laheye A, Berghman LR, Kuhn ER, Darras VM (1999) .J Exp. Zool. 284(7):776- 82 Modulation of the growth hormone (GH)-releasing activity of thyrotropin-releasing hormone (TRH) in the chicken by its gene-related peptide preproTRH(160-169) (Ps4): enhanced somatostatinergic tone? K L Geris, L R Berghman, A Ladram, E R Kühn, V M Darras and S Harvey (2000). Neuropeptides 34(1): 51-57. Shield characteristics are testosterone-dependent in both male and female moorhens Eens, M., Van Duyse, E., Berghman, L. & Pinxten, R. (2000) Hormones and Behavior 37(2):126-134. Immunocytochemical evidence for the existence of a lamprey luteinizing hormone releasing hormone type III-like peptide in the chicken hypothalamus. Berghman, L.R., D’Hondt, E., Puebla, N., Dees, L., Hiney, J., Sower, S. and Vandesande, F. (2000). British Poultry Science 41, S56-57. Chicken Luteinizing Hormone-Releasing Hormone-I and –II are located in distinct fiber terminals in the median eminence of the quail: a light and electron microscopic study. D’Hondt, E., Billen, J., Berghman, L.R., Vandesande, F. & Arckens, L. (2001) Belg. J. of Zool. 131(2):137-144. Choi Y, Johnson GA, Burghardt RC, Berghman LR, Joyce MM, Taylor KM, Stewart MD, Bazer FW, Spencer TE (2001). Interferon regulatory factor two restricts expression of interferon-stimulated genes to the endometrial stroma and glandular epithelium of the ovine uterus. Biol Reprod. in press.

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Blackwell, David W. Associate Dean for Graduate Programs and James eRA COMMONS USER NAME W. Aston/RepublicBank Professor of Finance

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) University of Tennessee Ph.D. 1986 Finance University of Tennessee B.S. 1981 Economics

A. Positions and Honors.

Positions and Employment 2002- 2007 James W. Aston/RepublicBank Professor of Finance and Associate Dean for Graduate Programs, Mays Business School, Texas A&M University 2002- 2007 James W. Aston/RepublicBank Professor of Finance and Head, Department of Finance, Mays Business School, Texas A&M University 2001- 2002 Director, KPMG LLP, Forensic & Litigation Services, Atlanta, GA 2000- 2001 Director, PricewaterhouseCoopers LLP, Financial Advisory Services, Atlanta, GA 1998- 1999 Manager, PricewaterhouseCoopers LLP, Financial Advisory Services, Atlanta, GA 1995- 1998 Associate Professor of Finance, Goizueta Business School, Emory University 1993- 1995 Associate Professor of Finance, Department of Finance, University of Houston 1991- 1993 Associate Professor of Finance, Department of Banking and Finance, University of Georgia 1985- 1991 Assistant Professor of Finance, Department of Banking and Finance, University of Georgia 1989 Visiting Assistant Professor of Business Administration, William E. Simon Graduate School of Business Administration, University of Rochester

Other Experience and Professional Memberships 2008- present Member, Board of Directors, The Washington Campus 2007- present Member, Board of Directors, Twin Cities Endowment 2006- present Editorial Board, Journal of Business Valuation and Economic Loss Analysis 2002- present Editorial Board, FMA Online 2002- present Consulting Finance Editor, John Wiley & Sons, Inc. 1998- 1999 President, Southern Finance Association 1997- 1998 Vice President-Program, Southern Finance Association 1997- 2000 Member, Board of Directors, Southern Finance Association 1994- 1999 Associate Editor, Journal of Financial Research 1992- 1995 Editorial Board, Journal of Business Research

Honors 1995 Most Notable Contribution to the Auditing Literature, 1995-2000, Journal of Accounting Research 1991 & 1992 Terry Research Fellowship, University of Georgia 1990 Outstanding Paper in Corporate Finance, Southern Finance Association Meetings 1985 Department of Banking and Finance, University of Georgia, Outstanding Teacher Award

B. Selected peer-reviewed publications (in chronological order).

1. David S. Kidwell, Richard L. Peterson, David W. Blackwell, and David A. Whidbee, Financial Institutions, Markets, and Money, Tenth Edition, 2008, John Wiley & Sons, Inc 2. David W. Blackwell, Mark Griffiths, and Drew Winters, Modern Financial Markets: Prices, Yields, and Risk Analysis, 2007, John Wiley & Sons, Inc. 3. "Changes in CEO Compensation Structure and the Impact of Firm Performance Following CEO Turnover," (With Donna Dudney and Kathleen A. Farrell), Review of Quantitative Finance and Accounting (forthcoming) 4. “Local Lending Markets: What a Small Business Owner/Manager Needs to Know,” (With Drew B. Winters), Quarterly Journal of Business and Economics 39(2), 2001. 5. "The Value of Auditor Assurance: Evidence from Loan Pricing." (With Thomas Noland and Drew B. Winters), Journal of Accounting Research, Spring 1998. (Winner of the award for “The Most Notable Contribution to the Auditing Literature, 1995-2000, Journal of Accounting Research) 6. "Banking Relationships and the Effect of Monitoring on Loan Pricing," Journal of Financial Research 20, 1997. (With Drew B. Winters) 7. "The Effect of Executive Compensation Policy on Long-Term Investment Expenditures," Advances in Financial Economics 3, 1997. (With Kathleen A. Farrell and Andreas Wunsch) 8. "The Relationship between Corporate Compensation Policies and Investment Opportunities: Empirical Evidence for Large Bank Holding Companies," Financial Management 24, 1995. (With Joseph F. Sinkey and M. Cary Collins) 9. "Thrift Scale Economies: An Alternative Approach," Quarterly Journal of Business and Economics 34, 1995. (With James E. McNulty and James A. Verbrugge) 10. "Accounting-Based Performance and the Turnover of Divisional Managers: Evidence from Texas Banks," Journal of Accounting and Economics 17, 1994. (With James A. Brickley and Michael S. Weisbach) 11. "Financial Innovation, Investment Opportunities, and Corporate Policy Choices for Large Bank Holding Companies," Financial Review 29, 1994. (With Joseph F. Sinkey and M. Cary Collins) 12. "The Impact of the Amount of Advance Notification of Plant Closings on Firm Value," Journal of Business Research 31, 1994. (With M. Wayne Marr and Michael F. Spivey) 13. "The Effect of Taxes on the Relative Valuation of Dividends and Capital Gains: Evidence from Dual- Class British Investment Trusts," Journal of Finance 46, 1991. (With James S. Ang and William L. Megginson) 14. "Plant Closing Decisions and the Market Value of the Firm," Journal of Financial Economics 26, 1990. (With M. Wayne Marr and Michael F. Spivey) 15. "Shelf Registration and the Reduced Due Diligence Argument: Implications of the Underwriter Certification and the Implicit Insurance Hypotheses," Journal of Financial and Quantitative Analysis 25, 1990. (With M. Wayne Marr and Michael F. Spivey) 16. "An Investigation of Cost Differences Between Public Sales and Private Placements of Debt," Journal of Financial Economics 22, 1988. (With David S. Kidwell) Reprinted in Studies in Financial Institutions: Non-Bank Intermediaries, 1993, McGraw-Hill Book Company, Christopher James and Clifford W. Smith, eds. 17. "The Economics of Leveraged Takeovers," Washington University Law Quarterly 65, 1987. (With Kenneth Lehn and Wayne Marr) 18. "A Note on Plant Closing Decisions: A Reply," Financial Management 22, 1993, FM Letters section. (With M. Wayne Marr and Michael F. Spivey) 19. "Industrial Organization and its Schools of Thought," Survey of Business, Summer 1984.

Mays Business School Texas A&M University Department of Management Faculty Data Sheet From January 1997

Victoria Buenger

EDUCATION

Degree: Ph.D. Major: Management Institution: Texas A&M University Year of Completion: 1990

M.A. Major: History Institution: Texas A&M University Year of Completion: 1983

B.A. Major: History, Magna Cum Laude Institution: Texas A&M University Year of Completion: 1981

EMPLOYMENT IN MAYS BUSINESS SCHOOL

• Current Rank: Visiting Assistant Professor of Management • Appointment to Current Rank: 1994 • Years of Service: 8 • Year of Initial Employment: 1994

COURSES TAUGHT IN MAYS BUSINESS SCHOOL SINCE 1997

• MGMT 466 Strategic Management • MGMT 466H Strategic Management--honors • MGMT 460 Managing Projects • MGMT 689 Human Resource Information Systems • MGMT 655 Survey of Management

SIGNIFICANT PROFESSIONAL DEVELOPMENT ACTIVITIES SINCE 1997

• Professional interaction: (conferences, workshops, programs, seminars attended) ƒ SAP20 SAP R/3 (Release 4.6) Overview Seminar—July 2000, Dallas, Texas ƒ Texas State Historical Association, program participant

• Incorporation of technology in research and teaching activities: ƒ Incorporated Web research assignments and Web-based textbook and readings into all courses. ƒ Incorporated application software (Microsoft Project 2000) in Managing Projects course. ƒ Incorporated application software (Microsoft Project 2000 and SAP R/3 HR Module) in Human Resources Information Systems

• Editorial Boards: ƒ Personnel Psychology—Book Review Editorial Board

• Manuscript Reviewing: ƒ Reviewed numerous manuscripts for the Academy of Management Journal, Organization Science, and the Journal of Management. ƒ Reviewed numerous manuscripts for national and regional meetings of the Academy of Management, in the Business and Policy, Organization and Management Theory, and Management History Divisions.

INTELLECTUAL CONTRIBUTIONS SINCE 1997

• Books and Chapters in Books: ƒ Texas Merchant: Marvin Leonard and Fort Worth (Texas A&M University Press, 1998).

• Book Reviews: ƒ Reviewed numerous books for Personnel Psychology and Business History Review.

SERVICE ACTIVITIES SINCE 1997

• Service on university, college, and department committees: • Department ƒ Member, Distance Learning Task Force, 1999-2000 ƒ Faculty Advisory, Management Society, 2001-2002

• College ƒ Coach, CBA Undergraduate Case Team, 1997-2002 ƒ Faculty Advisor, Undergraduate Business Consulting Association, 2000-2002 ƒ Faculty Advisor, Freshman Business Initiative, 2001-2002 ƒ Faculty Advisor, Mitte Scholars, 2000-2001

• Service to the Community ƒ Member, United Way Review Panel, College Station, Texas, 1997-1999. ƒ Moderator, Stewardship and Finance Committee, First Presbyterian Church, Bryan, 2001. ƒ Elder, First Presbyterian Church, Bryan, 1999-2001. ƒ Treasurer, Jane Long Middle School, PTO, 1999-2002. ƒ Manager, Brazos Magic ‘88, 1998-2002.

WORK IN PROGRESS

• Working Papers ƒ “Entrepreneurial Partnerships,” with Chris Tuggle. ƒ “Competitive Moves and Responses in the Retail Grocery Industry: Structural Determinants of Rivalry in Two Markets,” with Tom Agnew. ƒ “Rivalry and Strategic Decision Making Processes,” single author.

Principal Investigator/Program Director (Last, First, Middle):

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Burghardt, Robert C. Professor, Veterinary Integrative Biosciences, eRA COMMONS USER NAME Texas A&M University rburghardt EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) University of Michigan, Ann Arbor, MI B.S. 1969 Zoology Wayne State University, Detroit, MI M.S. 1973 Biology Wayne State University, Detroit, MI Ph.D. 1976 Biology Harvard Medical School, Boston, MA Postdoc 1976-78 Reproductive Biology A. Positions and Honors 1976 -1978 Ford Foundation Postdoctoral Fellow, Department of Anatomy and Laboratory of Human Reproduction and Reproductive Biology, Harvard Medical School 1978 -1987 Assistant, Associate Professor, Department of Biology, Texas A&M University (TAMU) 1982 -1987 Director, Electron Microscopy Center, TAMU 1987 -1991 Associate Professor, Department of Veterinary Anatomy, TAMU 1987 - Director, Image Analysis Laboratory, College of Veterinary Medicine, TAMU 1991 - Professor, Department of Veterinary Integrative Biosciences, TAMU 2005 - Chair, Faculty of Toxicology Texas A&M University Interdisciplinary Faculty Appointments: Faculty of Toxicology, 1991-present, Faculty, Center for Animal Biotechnology and Genomics, Institute of Biosciences and Technology, 1992- present; Faculty of Reproductive Biology, 1995-present; Faculty of Biotechnology, 2001-present Societies, Professional Activities, Honors & Awards: Societies: Society for the Study of Reproduction (SSR), Society of Toxicology. Professional Activities: Associate Editor, Biology of Reproduction, 1992-95; Editorial Boards, Cells Tissues Organs, 2004-; Journal of Applied Toxicology, 2006-; College of Vet. Medicine, Wiley Distinguished Teaching Professorship 2000-03; Chair, Publications Committee, SSR, 1996-99, 2005-07; Chair, Awards Committee, SSR, 2004-05; Director, SSR, 2000-03; Ad hoc reviewer: 41 different journals; Review committee service past 5 years: Ad hoc reviews, NSF (Integrative Animal Biology, Signal Transduction and Regulation), NIH (HED-1, Metabolism Reproduction, NIEHS, NIH/NIGMS MBRS), USDA (Animal Reprod Efficiency), Wellcome Trust (Joint Infrastructure Fund, UK), Veterans Health Administration, Israel Science Foundation, Natural Sciences and Engineering Research Council of Canada, March of Dimes. Honors & Awards: Association of Former Students, Distinguished Teaching Award, 1995;Vice Chancellor's Award in Excellence for Team Research in Uterine Biology and Pregnancy, 2005 B. Selected Peer-Reviewed Publications In Past 3 Years (From 196 peer-reviewed publications) Dunlap K, M Palmarini, M Verela, R Burghardt, K Hayashi, J Farmer, T Spencer (2006) Endogenous retro- iruses regulate peri-implantation placental growth and differentiation. Proc Natl Acad Sci 103:14390-14395. Farmer JL, RC Burghardt, FD Jousan, PJ Hansen, FW Bazer, TE Spencer (2007) Galectin 15 (LGALS15) functions to promote trophectoderm migration and attachment. FASEB J 22:548-560. Barhoumi R, RC Burghardt, E Tiffany-Castiglioni (2007) Effects of propofol on intracellular Ca2+ homeostasis in human astrocytoma cells. Brain Res 1145:11-18. Hayashi K, RC Burghardt, FW Bazer, TE Spencer (2007) WNTs in the Ovine uterus: potential regulation of peri-implantation ovine conceptus development. Endocrinology, 148:3496-3506. Joyce MM, JR Burghardt, RC Burghardt, RN Hooper, LA Jaeger, TE Spencer, FW Bazer, GA Johnson (2007) Pig conceptuses increase uterine interferon regulatory factor-1 (IRF1), but restrict expression to the stroma through estrogen-induced IRF-2 in the luminal epithelium. Biol Reprod, 77:292-302. Akintola AD, Z Crislip, JM Catania, G Chen, WE Zimmer R Burghardt, AR Parrish (2007) Promoter methylation is associated with the age-dependent loss of N-cadherin in the rat kidney. Am J Physiol Renal Physiol 294:F170-F176.

PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Biographical Sketch Format Page Principal Investigator/Program Director (Last, First, Middle): Satterfield M, K Dunlap, K Hayashi, RC Burghardt, TE Spencer, F Bazer (2007) Tight and adherens junctions in the ovine uterus: differential regulation by pregnancy and progesterone. Endocrinology 148:3922-3931. Laffin B, E Wellberg, H-I Kwak, RC Burghardt, RP Metz, T Gustafson, P Schedlin, WW Porter (2008) Loss of Single-minded-2s in the mouse mammary gland induces an epithelial mesenchymal transition associated with upregulation of SLUG and MMP2. Molec Cell Biol 26:1936-1946. Kim J, G Song, H Gao, JL Farmer, MC Satterfield, RC Burghardt, G Wu, GA Johnson, TE Spencer, FW Bazer (2008) Insulin-like growth factor 2 (IGF2) activates PI3K-AKT1 and MAPK cell signaling pathways and stimulates proliferation and migration of ovine trophectoderm cells. Endocrinol 149:3085-3094. Wu F, S Khan, Q Wu, R Barhoumi, R Burghardt, S Safe (2008) Ligand structure-dependent activation of estrogen receptor α / Sp by estrogens and xenoestrogens. J Ster Biochem Mol Biol 110:104-115. Bruce E, R Autenrieth, R Burghardt, KC Donnelly, T McDonald (2008) Using quantitative structure-activity relationships (QSAR) to predict toxic endpoints for polycyclic aromatic hydrocarbons (PAH). J Toxicol Environ Health. A. 71:1073-1084. Bridger PS, S Haupt, R Leiser, GA Johnson, RC Burghardt, H-R Tinneberg, C Pfarrer (2008) Integrin activation in bovine placentomes and in caruncular epithelial cells isolated from pregnant cows. Biol Reprod 79:274- 282. Banu SK, JB Samuel, JA Arosh, RC Burghardt, MM Aruldhas (2008) Lactational exposure to hexavalent chromium delays puberty by impairing ovarian development, steroidogenesis and pituitary hormone synthesis in developing Wistar rats. Toxicol Appl Pharmacol, 232:180-189. Joyce MM, JR Burghardt, RC Burghardt, RN Hooper, FW Bazer, GA Johnson (2008) Uterine major histocompatibility Class I molecules and Beta 2 Microglobulin are regulated by progesterone and conceptus interferons during pig pregnancy. J Immunol, 181:2494–2505. Dunlap KA, DW Erikson, RC Burghardt, FJ White, KM Reed, JL Farmer, TE Spencer, RR Magness, FW. Bazer, KJ Bayless, GA Johnson (2008) Progesterone and placentation increase secreted phosphoprotein one (SPP1 or osteopontin) in uterine glands and stroma for histotrophic and hematotrophic support of ovine pregnancy. Biol Reprod, 79:983-990. Bazer F, RC Burghardt, GA Johnson, T Spencer, G Wu (2008) Interferons and progesterone for establishment and maintenance of pregnancy: interactions among novel cell signaling pathways. Reprod Biol, 8:179-211. Loudet A, J Han, R Barhoumi, J-P Pellois, RC Burghardt, K Burgess (2009) Non-covalent delivery of proteins into mammalian cells. Org Biomol Chem 6(24): 4516-4522.. Song G, KA Dunlap, J Kim, DW Bailey, TE Spencer, RC Burghardt, GA Johnson, FW Bazer (2009) Stanniocalcin 1 is a luminal epithelial marker for implantation in pigs regulated by progesterone and estrogen. Endocrinology 150:936-950. Barhoumi R, JM Catania, AR Parrish, I Awooda, E Tiffany-Castiglioni, S Safe, RC Burghardt (2009) Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in breast epithelial cell lines. J Tox Sci 34:13-25. Banu S, A Starzinski-Powitz, V Speights, R Burghardt, J Arosh (2008) Induction of peritoneal endometriosis in nude mice using human immortalized endometriosis epithelial and stromal cells: A potential experimental tool to study molecular pathogenesis of endometriosis in human. Fertil Steril 91(5 Suppl):2199-2209. Burghardt RC, JR Burghardt, JD Taylor II, AT Reeder, BT Nguen, GA Johnson (2009) Enhanced focal adhesion assembly reflects increased mechanosensation and mechanotransduction at the maternal/conceptus interface and uterine wall during pregnancy in sheep. Reproduction, 137:567-582. Han J, A Loudet, RB Mouneimne, RC Burghardt, K Burgess (2009) A ratiometric pH reporter for observing protein-dye conjugates in living cells. J Am Chem Soc 131:1642-1643. Bazer F, T Spencer, G Johnson, R Burghardt, G Wu (2009). Comparative aspects of implantation. Reproduction 138:195-209. Wu L, A Loudet, R Barhoumi, R Burghardt, K Burgess (2009) Fluorescent cassettes for monitoring three- component interactions in vitro and ex vivo. J Am Chem Soc 131: 9156-9157. Barhoumi R, Y Qian , RC Burghardt, E Tiffany-Castiglioni (2009) Image analysis of Ca2+ signals as a basis for neurotoxicity assays: Promises and challenges. Neurotoxicol Teratol, Jun 22. [Epub ahead of print]. Erikson DW, RC. Burghardt, KJ Bayless, GA Johnson. (2009) Secreted phosphoprotein I (SPP1, osteopontin) binds to integrin alphavbeta6 on trophectoderm cells and integrin alphavbeta3 on uterine epithelial cells and promotes trophectoderm cell adhesion and migration. Biol Reprod, July 1. [Epub ahead of print].

PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page Principal Investigator/Program Director (Last, First, Middle):

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Robert S. Chapkin Professor and University Faculty Fellow eRA COMMONS USER NAME Robert_S_Chapkin EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) University of Guelph, Ontario, Canada B.Sc. 1981 Nutrition & Biochemistry University of Guelph, Ontario, Canada M.Sc. 1983 Nutrition University of California - Davis Ph.D. 1986 Nutr. & Physiol. Chemistry University of California - Davis Post-doc 1986-88 Cell Biology A. Professional Experience: 1986-1988: Postdoctoral Fellow, Immunology-Tumor Biology Laboratory, Department of Cell Biology and Human Anatomy, School of Medicine, University of California-Davis. 1988-1993: Assistant Professor, Human Nutrition, Center for Environmental and Rural Health, Texas A&M University. 1992: Pew National Nutrition Program Scholar. 1994-1999: Associate Professor, Department of Veterinary Integrated Biosciences and Faculty of Nutrition. 1999-Present: Professor, Nutrition, Center for Environmental and Rural Health (CERH), Texas A&M University. 2002-2005: Chair, Intercollegiate Faculty of Nutrition, Texas A&M University 2004-Present: Member, Division Hematol./Oncology, Scott & White Hospital, Texas A&M Health Sci. Center. Director, Genomics and Bioinformatics Facility Core, CERH, Texas A&M University. Honors and National Review Panels: 1991-1992: Pew National Nutrition Program Faculty Scholar. 1996: American Society for Nutritional Sciences Bio Serv Award in Experimental Animal Nutrition. 1999-Present: American Institute for Cancer Research Grant Review Panel 2000: Texas A&M Faculty Fellow Award 1999-2000: Chair, Diet-Cancer Research Interest Section, American Society for Nutritional Sciences. 2000-2001: NIH Temporary Panel Member: Metabolic Pathology Study Section 2001-2006: Texas A&M University Faculty Fellow Scholar 2002-2004: Editorial Board, Journal of Nutrition 2002-2005: NIH Charter Member: Metabolic Pathology/Chemo-Dietary prevention (CDP) Study Sections 2005-2007: Editorial Board, Chemistry & Physics of Lipids 2006: Sigma Xi Distinguished Scientist Award, Texas A&M University Chapter 2007: Texas A&M Senior Faculty Fellow Award

B. SELECTED PEER REVIEWED PUBLICATIONS FROM A TOTAL OF 171: 1. S.S. Kolar, R. Barhoumi, E.S. Callaway, Y.Y. Fan, N. Wang, J.R. Lupton and R.S. Chapkin. Synergy between docosahexaenoic acid and butyrate elicits p53-independent apoptosis via mitochondrial Ca2+ accumulation in human colon cancer cells and primary cultures of rat colonic crypts. American Journal of Physiology: GI and Liver Physiology 293:G935-G943, 2007. 2. R.S. Chapkin, N. Wang, Y.Y. Fan, J.R. Lupton and I.A. Prior. Docosahexaenoic acid alters the size and distribution of cell surface microdomains. Biochimica et Biophysica Acta – Biomembranes 1778:466-471, 2008. PMC2244794 3. R.S. Chapkin, J. Seo, D.N. McMurray and J.R. Lupton. Mechanisms by which docosahexaeonic acid and related fatty acids reduce colon cancer risk and inflammatory disorders of the intestine. Chemistry & Physics of Lipids 153:14-23, 2008. PMC2430411. 4. T.V. Apanasovich, D. Ruppert, J.R. Lupton, N. Popovic, N.D. Turner, R.S. Chapkin and R.J. Carroll. Aberrant crypt foci and semiparametric modeling of correlated binary data. Biometrics 64:490-500, 2008. PMC2659549

PHS 398/2590 (Rev. 09/04) Page1 Biographical Sketch Format Page Principal Investigator/Program Director (Last, First, Middle): 5. J. Vanamala, A. Glagolenko, P. Yang, R.J. Carroll, M.E. Murphy, R.A. Newman, R.S. Chapkin and J.R. Lupton. Dietary fish oil and pectin enhance colonocyte apoptosis in irradiated rats in part by suppressing protumorigenic signaling. Carcinogenesis 29:790-796, 2008. PMC2659531 6. Q. Jia, J.R. Lupton, R. Smith, B. Weeks, E. Callaway, L.A. Davidson, W. Kim, Y.Y. Fan, P. Yang, R. Newman, J. Kang, D.N. McMurray and R.S. Chapkin. Reduced colitis-associated colon cancer in Fat-1 (n-3 fatty acid desaturase) transgenic mice. Cancer Research 68:3985-3991, 2008. PMC2648804 7. R.S. Chapkin, D.N. McMurray, L.A. Davidson, B.S. Patil, Y.Y. Fan and J.R. Lupton. Bioactive dietary long chain fatty acids: Emerging mechanisms of action. British Journal of Nutrition 100:1152-1157, 2008. PMC2648819 8. K.C. Crim, L. Sanders, M.Y. Hong, S. Taddeo, N.D. Turner, R.S. Chapkin and J.R. Lupton. Upregulation of p21waf1/cip1 expression in vivo by butyrate administration can be chemoprotective or chemopromotive depending on the lipid component of the diet. Carcinogenesis 29:1415-1420, 2008. PMC2659529 9. R.S. Chapkin, B.A. Kamen, E.S. Callaway, L.A. Davidson, N.I. George, N. Wang, J.R. Lupton and R.H. Finnell. Use of a novel genetic mouse model to investigate the role of folate in colitis-associated colon cancer. Journal of Nutritional Biochemistry 79:209-214, 2008. PMC2710403 10. W. Kim, Y.Y. Fan, R. Barhoumi, R. Smith, D.N. McMurray and R.S. Chapkin. n-3 polyunsaturated fatty acids alter membrane raft accumulation at the site of T-cell activation. Journal of Immunology 181:6236-6243, 2008. PMC2597670. 11. C. McFarland, Y.Y. Fan, R.S. Chapkin, B. Weeks and D.N. McMurray. Dietary polyunsaturated fatty acids modulate resistance to M. tuberculosis in guinea pigs. Journal of Nutrition 138:2123-2128, 2008. PMC2635522 12. Y.Y. Fan, W. Kim, E. Callaway, R. Smith, Q. Jia, L. Zhou, D.N. McMurray and R.S. Chapkin. fat-1 transgene expression prevents cell culture-induced loss of membrane n-3 fatty acids in activated CD4+ T-cells. Prostaglandins Leukotrienes & Essential Fatty Acids 79:209-214, 2008. PMC Journal – In Process. 13. R.S. Chapkin. Reappraisal of the essential fatty acids. In: Fatty Acids in Food and Their Health Implications, 3rd Edition. (Chow, C.K. ed.), CRC Press, pp. 675-691, 2008. 14. C.A. Warren, K.J. Paulhill, L.A. Davidson, J.R. Lupton, S.S. Taddeo, M.Y. Hong, R.J. Carroll, R.S. Chapkin and N.D. Turner. Quercetin may suppress rat aberrant crypt foci by suppressing inflammatory mediators that influence proliferation and apoptosis. Journal of Nutrition 139:101-105, 2009. PMC Journal – In Process. 15. V.E. Kagan, A. Bayir, H. Bayir, D. Stoyanovsky, G.G. Borienko, Y.Y. Tyurina, P. Wipf, J. Atkinson, J.S. Greenberger, R. S. Chapkin and N.A. Belikova. Mitochondria-targeted disruptors and inhibitors of cyt c/CL peroxidase complexes: A new strategy in anti-apoptotic drug discovery. Molecular Nutrition 53(1):104-14, 2009. PMC2659540 16. C. Zhao, I. Ivanov, E.R. Dougherty, T.J. Hartman, E. Lanza, N.H. Colburn, J.R. Lupton, L.A. Davidson and R.S. Chapkin. Non-invasive detection of candidate molecular biomarkers in subjects with a history of insulin resistance and colorectal adenomas. Cancer Prevention Research 2:590-597, 2009. PMC Journal – In Process. 17. W. Kim, Y.Y. Fan, R. Smith, B. Patil, G.K Jayaprakasha, D.N. McMurray, and R.S. Chapkin. Dietary curcumin and limonin suppress CD4+ T-cell proliferation and interleukin-2 production in mice. Journal of Nutrition 139:1042-1048, 2009. 18. W. Kim, D.N. McMurray and R.S. Chapkin. Chemotherapeutic properties of n-3 polyunsaturated fatty acids – old concepts and new insights. Immun. Endoc. Metab. Agents in Med. Chem. 9:38-44, 2009. PMC Journal – In Process. 19. Y.Y. Fan, Y. Zhan, H.M. Aukema, L.A. Davidson, L. Zhou, E. Callaway, Y. Tian, B.R. Weeks, J.R. Lupton, S. Toyokuni and R.S. Chapkin. Proapoptotic effects of (n-3) fatty acids are enhanced in colonocytes of manganese-dependent superoxide dismutase knockout mice. Journal of Nutrition 139:1328-1332, 2009. PMC2696987

PHS 398/2590 (Rev. 09/04) Page 2 Continuation Format Page Cheng, Zhengdong

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Cheng, Zhengdong Assistant Professor of Chemical Engineering eRA COMMONS USER NAME zcheng EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) University of Sci. & Tech. of China, Hefei, Anhui, B.S. 1990 Modern Physics Institute of High Energy Physics, Beijing, China M.S. 1993 Particle Physics Princeton University Ph.D 1999 Condensed Matter ExxonMobil Research & Engineering Company Postdoc 00-01 Complex Fluids Harvard University Postdoc 02-04 Complex Fluids

A. Positions and Honors. Positions and Employment 2001-2002 Engineer, DiCon Fiberoptics, CA 2004- Assistant Professor, Chemical Engineering, Texas A&M University, College Station 2004- Assistant Professor, the Professional Program in Biotechnology, TAMU 2005- Assistant Professor, Materials Science and Engineering, TAMU Honors 1989 Ilida Corp. Prize for Distinguished Experimental Study Peer Review:

Panel Member: USDA Panel Review, Nanoscale Science and Engineering for Agriculture and Food Systems, August 2004 Grant Review, United States-Israel Binational Agricultural Research and Development Fund, November, 2004 ACS PRF proposal, Aug., 2006 Louisianan State, Out-of-state experts participating in the in-depth mail review, Dec. 2007. Served on review panel for National Science Foundation (CBET Particular Multiphase Process program), Nov., 2007. ACS PRF proposal, July, 2007 A*STAR-NKTH proposal for Science & Engineering Research Council Agency for Science, Technology & Research, Singapore (Jan., 2009). Ad hoc reviewer: Physical Review Letters, Physical review E, Journal of Microfluidics and Nanofluidics, Journal of Micromechanics and Microengineering, Langmuir, Biommifrofluidics, Journal of Polymer Science Part B: Polymer Physics, IEEE Transactions on Nanotechnology, Journal of Colloid and Interface Science, ASME Journal of Fluids Engineering, Electrochemistry Communications Issued US Patents # US 6839137 (Jan. 2005) Asphatene Aggregation in Petroleum Oil Mixtures Determined by Small Angle Light Scatteri with T.G. Mason et al., ExxonMobil Research & Engineering Company

PHS 398/2590 (Rev. 09/04) Page Biographical Sketch Format Page

Cheng, Zhengdong

# US 11246911 (July 2006) Formation and Control of Fluidic Species with D.R. Link, G. Cristobal, D.A. Weitz, M. Marquez, Harvard University International patent numbers: AU 2004229440 (Oct. 2005); EP 2004759306 (Jan. 2006); JP 2006509830 B. Selected peer-reviewed publications (in chronological order). (Publications selected from over 50 peer-reviewed publications) 1. Cheng, Z. D.; Russell, W. B.; Chaikin, P. M., Controlled growth of hard-sphere colloidal crystals. Nature 1999, 401, (6756), 893-895. 2. Harrison, C.; Adamson, D. H.; Cheng, Z. D.; Sebastian, J. M.; Sethuraman, S.; Huse, D. A.; Register, R. A.; Chaikin, P. M., Mechanisms of ordering in striped patterns. Science 2000, 290, (5496), 1558-1560. 3. Cheng, Z.; Chaikin, P. M.; Mason, T. G., Light streak tracking of optically trapped thin microdisks. Physical Review Letters 2002, 89, (10), 108303. 4. Cheng, Z. D.; Chaikin, P. M.; Zhu, J. X.; Russel, W. B.; Meyer, W. V., Crystallization kinetics of hard spheres in microgravity in the coexistence regime: Interactions between growing crystallites. Physical Review Letters 2002, 88, (1), 015501. 5. Link, D. R.; Grasland-Mongrain, E.; Duri, A.; Sarrazin, F.; Cheng, Z. D.; Cristobal, G.; Marquez, M.; Weitz, D. A., Electric control of droplets in microfluidic devices. Angewandte Chemie-International Edition 2006, 45, (16), 2556-2560. 6. Gong, T. Y.; Shen, J. Y.; Hu, Z. B.; Marquez, M.; Cheng, Z. D., Nucleation rate measurement of colloidal crystallization using microfluidic emulsion droplets. Langmuir 2007, 23, (6), 2919-2923. 7. Kim, H.; Luo, D.; Link, D.; Weitz, D. A.; Marquez, M.; Cheng, Z., Controlled production of emulsion drops using an electric field in a flow-focusing microfluidic device. Applied Physics Letters 2007, 91, 133106. 8. Luo, D.; Pullela, S. R.; Marquez, M.; Cheng, Z., Cell encapsules with tunable transport and mechanical properties. Biomicrofluidics 2007, 1, (3), 034102. 9. Lee, I.; Yoo, Y.; Cheng, Z.; Jeong, H. Generation of monodisperse mesoporous silica microspheres with controllable size and surface morphology via a microfluidic device. Advanced Functional Materials 18, 2009, 4014. (Appeared on the journal cover) 10. Mejia A. (Started as an undergraduate); He, P.; Luo, D.; Marquez, M; Cheng, Z. Uniform discotic wax particle via electrospray emulsification. J. Colloid and Interface Science 334, 2009, 22. 11. Wu, J.; Li, Y.; Lu, D.; Liu, Z; Cheng, Z.; He, L. Measurement of the membrane elasticity of red blood cell with osmotic pressure by optical tweezers. Cryoletters 30, 2009, 89. 12. Sun, D; Sue, H-J.; Cheng, Z.; Martinez-Ratonm Y.; Velasco E. Stable smectic phase in suspensions of polydisperse colloidal platelets with identical thickness Physical Review E 80, 2009, 041704. 13. Cheng, Z. and He, L.Q. Colloid, Drops and Cells (Book in English. August, 2009. Published by the Press of University of Science and Technology of China, Hefei, China). C. Research Support 1. American Chemical Society Petroleum Research Fund, Type G, 08/01/06-07/31/08 Microwax disks: Fabrication and Characterization 2. INEST – Texas A&M University Research Agency: I’NEST Group Interdisciplinary Network of Emerging Science & Technologies, New Technology Research Department, Research Center, PMUSA. Period: January 1, 2005 through Dec 31, 2008 Amount: $1,500,000 , plus $153,000 has been received in 5 years as gift to Texas A&M research foundation. 3. Advanced Energy Consortium, 2010-2013, $655,982. Multi-Functional Nanosensors Based on AAO Nano-Channels for Oil and Gas Exploration Bao,J.M. (PI) , Yu,Q.K., Liu, R., (University of Houston) and Cheng, Z. (CoPI)

PHS 398/2590 (Rev. 09/04) Page Biographical Sketch Format Page

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Craig J. Coates Associate Professor eRA COMMONS USER NAME CJCOATES EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) Australian National University, Canberra, Biochemistry and B.Sc. (Hons) 1988-1991 Australia Molecular Biology Australian National University, Canberra, Biochemistry and Ph.D. 1992-1996 Australia Molecular Biology Postdoctoral University of California, Irvine, Irvine, California 1996-1998 Insect Molecular Biology Training

A. Positions and Honors

Employment

1996-1998 Postdoctoral Research Associate, UCI, Irvine California 1999 -2005 Assistant Professor, Texas A&M University 2005 - Associate Professor, Texas A&M University Member, Faculty of Genetics Member, Faculty of Biotechnology 2008 - Chair, Faculty of Genetics

Other Experience and Professional Memberships

2005 Chair, Session VI at the 4th International Workshop on Transgenesis and Genomics of Invertebrate Organisms 2005 Study Section Member, NIH - IDM-M 2005 Study Section Member, NIH – VB 2007 USDA, CREES, Ad Hoc Reviewer Welcome Trust, Ad Hoc Reviewer BBSRC, Ad Hoc Reviewer 2008 USDA-NRI, Genomics Study Section Member

Honors

2002 Texas A&M University Center for Teaching Excellence Montague Scholar

B. Selected peer-reviewed publications (Postdocs and Graduate Students as shown)

Tian, H., Vinson, S.B., and Coates, C.J. (2004) Differential gene expression between alate and dealate queens in the red imported fire ant, Solenopsis invicta Buren (Hymenoptera: Formicidae) Insect Biochemistry and Molecular Biology 34: 937-49.

Pledger, D.W., Fu, Y.Q. and Coates, C.J. (2004) Analyses of cis-acting elements that affect the transposition of MosI mariner transposons in vivo. Molecular Genetics and Genomics 272: 67-75

Gray, C. and Coates, C.J. (2004) High-level gene expression in Aedes albopictus cells using a baculovirus Hr3 enhancer and IE1 transactivator. BioMed Central 5: 8.

Mohammed, A. and Coates, C.J. (2004) Promoter and piggyBac activities within embryos of the potato tuber moth, Phthorimaea operculella, Zeller (Lepidoptera: Gelechiidae). Gene, 342: 293-301.

Chowdhury, M.H., Julian, A.M., Coates, C.J. and Cote, G.L. (2004) Detection of differences in oligonucleotide influenced aggregation of colloidal gold nanoparticles using absorption spectroscopy. Journal of Biomedical Optics, 9: 1347-1357.

Adelman, Z.N., Jasinskiene, N., Vally, K.J.M., Peek, P., Travanty, E.A., Olson, K.E., Brown, S.E., Stephens, J.L., Knudson, D.L., Coates, C.J. and James, A.A. (2004) Formation and loss of large, unstable tandem arrays of the piggyBac transposable element in the yellow fever mosquito, Aedes aegypti. Transgenic Research 13:411-25.

Gray, C.E. & Coates, C.J. (2005) Cloning and characterization of cDNAs encoding putative CTCFs in the mosquitoes, Aedes aegypti and Anopheles gambiae. BMC Molecular Biology 6:16.

Pledger, D.W. & Coates, C.J. (2005) Mutant MosI mariner transposons are hyperactive in Aedes aegypti. Insect Biochem. Mol. Biol.,35:1199-207

Li, H., Medina, F., Vinson, S.B. & Coates, C.J. (2005) Isolation, Characterization and Molecular Identification of Bacteria from the Red Imported Fire Ant (Solenopsis invicta) Midgut. Journal of Invertebrate Pathology 89:203-9

Kolb, A.F., Coates, C.J., Kaminski, J.M., Summers, J.B., Miller, A.D. & Segal, D.J. (2005) Site-directed genome modification: nucleic acid and protein modules for targeted integration and gene correction. Trends in Biotechnology 23:399-406

Coates, C.J., Kaminski, J.M., Summers, J.B, Segal, D.J., Miller, A.D., & Kolb, A.F. (2005) Site-directed genome modification: derivatives of DNA modifying enzymes as targeting tools. Trends in Biotechnology 23:407-19

Wu, S.C., Meir, Y.J., Coates, C.J., Handler, A.M., Pelczar, P., Moisyadi, S., Kaminski, J.M. (2006) piggyBac is a flexible and highly active transposon as compared to sleeping beauty, Tol2, and Mos1 in mammalian cells. Proc Natl Acad Sci U S A. 103:15008-13.

Maragathavally, K.J., Kaminski, J.M., Coates, C.J. (2006) Chimeric Mos1 and piggyBac transposases result in site-directed integration. FASEB J. 20:1880-2.

Wilson, M.H., Coates. C.J., George, A.L. (2007) PiggyBac Transposon-mediated Gene Transfer in Human Cells. Mol. Ther. 15:139-45.

Shinohara, E.T., Kaminski, J.M., Segal, D.J., Pelczar, P., Kolhe, R., Ryan, T., Coates, C.J., Fraser, M.J., Handler, A,M,, Yanagimachi, R., Moisyadi, S. (2007) Active integration: new strategies for transgenesis. Transgenic Res. 16:333-9.

Wu, S. C-Y., Maragathavally, K.J., Coates, C.J. and Kaminski, J. M. (2008) Steps Towards Targeted Insertional Mutagenesis with Class II Transposable Elements. In: Chromosomal Mutagenesis, MiMB, Vol 435, Humana Press.

Vinson, S.B., Pietrantonio, P.V., Lu, H-L., Coates, C.J. (2008) The physiology of reproduction in the imported fire ant Solenopsis invicta Buren. Recent Advances in Insect Physiology, Toxicology and Molecular Biology, 153-171.

Medina F, Li H, Vinson SB, Coates CJ. (2009) Genetic Transformation of Midgut Bacteria from the Red Imported Fire Ant (Solenopsis invicta). Curr Microbiol. 58:478-82.

Principal Investigator/Program Director (Last, First, Middle):

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Cothran, Ernest Gus Clinical Professor eRA COMMONS USER NAME

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) North Texas State University B.S. 1973 Biology North Texas State University M.S. 1975 Genetics University of Oklahoma Ph.D. 1982 Genetics

A. Positions and Honors.

Positions and Employment

1981-1982 Research Analyst, Population Genetics Laboratory, Savannah River Ecology Laboratory, Aiken, SC 1982-1985 Postdoctoral Scientist, Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 1985-1986 Assistant Scientist, Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 1986-1992 Assistant Research Professor, Department of Veterinary Science, University of Kentucky, Lexington, KY 1991-1992 Adjunct Professor, Department of Biological Sciences, University of North Texas, Denton, TX 1992-2000 Associate Research Professor, Department of Veterinary Science, University of Kentucky, Lexington, KY 2000-2006 Research Professor, Department of Veterinary Science, University of Kentucky, Lexington, KY 2006- Clinical Professor, Department of Veterinary Integrative Biosciences, College of Veterinary Medicine, Texas A&M University, College Station, TX Other Experience and Professional Memberships

American Association for the Advancement of Science Society for the Study of Evolution Society of Systematic Biology Phi Sigma Sigma Xi American Society of Mammalogists International Society for Animal Genetics - Elected to Standing Committee for Genetics of the Horse, 1988,1992, Chairman 2004 . Elected to Standing Committee for Genetics of Deer, 1992-present ISAG/FAO Domestic Animal Relationships Programme advisory committee. 1995-present.

PHS 398/2590 (Rev. 09/04) Page Biographical Sketch Format Page Principal Investigator/Program Director (Last, First, Middle):

Elected to Standing Committee of Thoroughbred Horses 1994 and Chairman of Committee 1996. Elected to Standing Committee for Domestic Animal Genetic Diversity 1996 - present. American Genetic Association Society of Conservation Biologists Society for Molecular Biology and Evolution

B. Selected peer-reviewed publications (in chronological order).

(Publications selected from 76 peer-reviewed publications) Cothran, E.G., L.R. Weitkamp, S.A. Guttorsmen, and J.W. MacCluer. 1986. Genetic variability, inbreeding, and reproductive performance in Standardbred horses. Zoo Biology. 5:191-201. Bailey, E., K.T. Graves, E.G. Cothran, R. Reid, T.L. Lear, and R.B. Ennis. 1995. Synteny mapping horse microsatellite markers using a hetero-hybridoma panel. Animal Genetics. 26:177-180. Guerin, G., E. Bailey, D. Bernoco, I. Anderson, D.F. Antczak, K. Bell, M.M. Binns, A.T. Bowling, R. Brandon, G. Cholewinski, E.G. Cothran, H. Ellegren, M. Forster, S. Godard, P. Horin, M. Ketchum, G. Lindgren, H. McPartian, J.-C. Meriaux, J.R. Mickelson, L.V. Millon, J. Murray, A. Neau, K. Roed, K. Sandberg, Y.-L. Shiue, L.C. Skow, M. Stott, J. Swinburne, S.J. Valberg, H. van Haeringen, W.A. van Haeringen, and J. Ziegle. 1999. Report of the International Equine Gene Mapping Workshop: Male linkage map. Animal Genetics 30:341-354. Lieto, L.D. and E.G. Cothran. 2001. Characterization of expressed sequence tags generated from skin cDNA clones of Equus caballus by single pass sequencing. Animal Biotechnology 12:87-97. Cothran, E.G., E. Van Dyk and F.J. Vander Mewre. 2001. Genetic variation in the feral horses of the Namib Desert, Namibia, Africa. J. of the South African Vet. Assoc. 72:18-22. Lieto, L.D. and E.G. Cothran. 2003. The Epitheliogenesis imperfecta locus maps to equine chromosome 8 in American Saddlebred horses. Cytogenetic and Genomic Research 102:207-210. Lindgren, G., N. Backstrom, J. Swineburne, L. Hellborg, A. Einarsson, K. Sandberg, G. Cothran, C. Vila, M. Binns, and H. Ellegren. 2004. Limited number of patrilines in horse domestication. Nature Genetics 36:335-336. Cothran, E.G., R. Juras, and V. Macijauskiene. 2005. Mitochondrial DNA D-loop sequence variation among 5 maternal lines of the Zemaitukai horse breed. Genetics and Molecular Biology, 28:677-681. Luis, C., C. Bastros-Silveira, E.G. Cothran, and M.M. Oom. 2006. Iberian origins of New World horse breeds. Journal of Heredity 97:107-113. Brunberg, E., L. Andersson, G. Cothran, K. Sandberg, S. Mikko, and G. Lindgren. 2006. A missense mutation in PMEL17 is associated with Silver dapple coat color in the horse. BMC Genomics 7:46-55. Luis, C., R. Juras, M.M. Oom, and E.G. Cothran. 2007. Genetic diversity and relationships of Portuguese and other horse breeds based on protein and microsatellite loci variation. Animal Genetics 38:20-27. Andersson, L.S., R. Juras, D.T. Ramsey, J. Eason-Butler, S. Ewart, G. Cothran, and G. Lindgren. 2009. Equine Multiple Congenital Ocular Anomalies maps to a 4.9 megabase interval on horse chromosome 6. BMC Genetics. 9:88-97. C. Research Support

Ongoing Research Support

01/01/2003-12/31/2013 U.S. Department of the Interior, Bureau of Land Management. Genetic variation in feral horse and burro herds. Total cost $355,000.00.

07/01/2007-06/31/2008 Peruvian Paso Breeders Association. The genetic basis of Degenerative Suspensory Ligament Demitis in the Peruvian Paso horse. Total cost $15,000.00.

PHS 398/2590 (Rev. 09/04) Page Continuation Format Page

Program Director/Principal Investigator (Last, First, Middle):

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Timothy A. Cudd Professor eRA COMMONS USER NAME (credential, e.g., agency login) TACUDD EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) University of Tennessee, Knoxville 1976-1979 Preveterinary studies University of Tennessee, Knoxville DVM 1979-1982 Veterinary Medicine University of Florida, Gainesville PhD 1988-1992 Physiology University of Florida, Gainesville Postdoc 1992-1994 Fetal Physiology

Positions and Honors. 1988-1990 Doctoral Student University of Florida, Dept. of Physiological Sciences 1990-1992 Postdoctoral Fellow University of Florida, Dept. of Physiology 1992-1993 Postdoctoral Associate University of Florida, Dept. of Physiology 1993-1994 Assistant Scientist University of Florida, Dept. of Physiology 1994-2000 Assistant Professor Texas A&M University, Dept. of Vet. Physiology & Pharmacology 2000-2006 Assoc. Professor Texas A&M University, Dept. of Vet. Physiology & Pharmacology 2003-present Assoc. Professor (Joint) Texas A&M University System Health Science Center, College of Medicine, Dept. of Neuroscience and Experimental Therapeutics 2006-present Professor Texas A&M University, Dept. of Vet. Physiology & Pharmacology

1976 Phi Eta Sigma 1986-1990 American Association of Equine Practitioners Pediatrics Committee Member. 1986-1998 International Society of Veterinary Perinatology Editorial Committee Member. 1988-1993 International Society of Veterinary Perinatology Secretary Treasurer. 1988-1998 International Society of Veterinary Perinatology Board Member. 1992-1993 International Society of Veterinary Perinatology President. 1994 American Heart Association, Florida Affiliate Peer Review Committee. 1995 Invited speaker, P.D. Rossdale International Workshop on Equine Perinatology 2001 The Wellcome Trust, ad hoc reviewer 2002 NIH NICHD ad hoc reviewer 2002-2005 American Heart Association, Western Peer Review Committee 2002-present Michael E. DeBakey Institute Charter Fellow, TAMU 2003-Present Member of the Cardiovascular Research Institute, TAMU System 2003 Pfizer Award for Research Excellence, College of Veterinary Medicine, TAMU 2003 Invited speaker, Indiana University Purdue University at Indianapolis, Dept. of Psychology 2003-present Link Equine Research Endowment, Texas A&M University, Peer Review Committee 2004 Invited speaker, No Name Society Annual Meeting, Amelia Island, FL. 2005 Invited speaker, Annual meeting of Association of Anatomy Cell Biology Neurobiology Chairpersons, Kapalua, Maui. 2006 Texas A&M University Faculty of Neuroscience membership 2007 Belgian Science Policy on Drugs Grant Reviewer 2007 Invited speaker, Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill 2008 Invited speaker, Consortium for Investigation of FASD, NIAAA, Rockville, MD 2008 Invited speaker, Interdisciplinary Faculty of Reproductive Biology, Texas A&M University, College Station, TX

PHS 398/2590 (Rev. 11/07) Page 1 Biographical Sketch Format Page

Selected peer-reviewed publications (in chronological order). 1. Koterba, A.M., Adams, R., McClure, J.R., Cudd, T.A. Renal and urinary tract function and dysfunction in the neonatal foal. Proc. Am. Assoc. Equine Pract. 659-671, l985. 2. Toal, R.L. Cudd, T.A. Equine neonatal thoracic radiography; A radiographic-pathologic correlation. Proc. Am. Assoc. Equine. Pract. 117-128, 1987. 3. Cudd, T.A., Toal, R. L. The use of clinical findings, abdominocentesis and abdominal radiographs to assess surgical vs. non-surgical abdominal disease in the foal. Proc. Am. Assoc. Eq. Pract. 41-53, 1987. 4. Roszel, J.F., Freeman, K.P., Slusher, S.H., Morris, W.R., Haury, K.D., Cudd, T.A. Siderophages in pulmonary cytology specimens from racing and non-racing horses. Proc. Am. Assoc. Equine Pract. 321-329, 1987. 5. Cottrill, C.M., Cudd, T.A., O'Connor, W.N., Rantanen, N.W. Persistence of fetal circulatory pathways in a newborn foal. Equine Vet. J. 19:252-255, 1987. 6. Cudd, T.A., Pauly, T.H. Necrotizing enterocolitis in two equine neonates. Comp. Cont. Ed. Pract. Vet. 9:88-93, 1987. 7. Adams, R., Koterba, A.M., Brown, M.P., Cudd, T.A., Baker, W.A. Exploratory celiotomy for gastrointestinal disease in neonatal foals: A review of 20 cases. Equine Vet. J. 20:9-12, 1988. 8. Adams, R., Koterba, A.M., Cudd, T.A., Baker, W.A. Exploratory celiotomy for suspected urinary tract disruption in neonatal foals: A review of 18 cases. Equine Vet. J. 20:13-17, 1988. 9. Freeman, K.P., Cline, J.M., Simmons, R., Wilkins, P., Cudd, T.A., Perry, B. J. Recognition of bronchopulmonary dysplasia in a neonatal foal. Equine Vet. J. 21:292-296, 1989. 10. Cudd, T.A., Mayhew, I.G., Cottrill, C.M. Agenesis of the corpus callosum, the Dandy Walker Syndrome, and cerebellar vermian hypoplasia in a foal: premortem diagnosis by clinical evaluation and CT scanning. Equine Vet. J. 21:378-381, 1989. 11. Humber, K.A., Beech, J., Cudd, T.A., Gardner, S.Y., Sommer, M.M. Azothioprine for treatment of immune-mediated thrombocytopenia in two horses. J. Am. Vet. Med. Assoc. 199:591-594, 1991. 12. Cudd, T.A., Wood, C.E. Does intracarotid PGE2 increase plasma ACTH concentration in conscious adult ewes? Am. J. Physiol. 261 (Endocrinol. Metab. 24): E395-E401, 1991. 13. Cudd, T.A., Wood, C.E. Prostaglandin E2 releases ovine fetal ACTH from a site not perfused by the carotid vasculature. Am. J. Physiol. 263 (Regulatory, Integrative Comp. Physiol.32) : R136-R140, 1992. 14. Cudd, T.A., Wood, C.E. Prostanoid cascade inhibition prevents the cardiovascular and adrenocortropic responses to mineral acid infusion in conscious sheep. Am. J. Physiol. 264 (Regulatory, Integrative Comp. Physiol. 33): R1235-R1241, 1993. 15. Wood, C.E., Kane, C., Engelke, K., Cudd, T.A. Fetal ACTH and blood pressure responses to thromboxane mimetic U46619. Am. J. Physiol. (Regulatory, Integrative Comp. Physiol. 34): R858-R862, 1993. 16. Cudd, T.A., Castro, M.I., Wood, C.E. Content, in vivo release and bioactivity of fetal pulmonary immunoreactive adrenocorticotropin. Am. J. Physiol. (Endocrinol. Metab. 28): E667-E672, 1993. 17. Cudd, T.A., Wood, C.E. Thromboxane A2 receptor antagonism prevents the hormonal and cardiovascular responses to mineral acid infusion. Am. J. Physiol. (Regulatory, Integrative Comp. Physiol. 36): R1235-R1240, 1994. 18. Cudd, T.A., LeBlanc, M., Silver, M., Norman, W., Madison, J., Keller-Wood, M., Wood, C.E. Ontogeny and ultradian rhythms of adrenocorticotropin and cortisol in the late gestation fetal horse. J. Endocrinol., 144: 271-283, 1995. 19. Cudd, T.A., Wood, C.E. Secretion and clearance of immunoreactive ACTH by fetal lung. Am. J. Physiol. (Endocrinol. Metab.31): E845-E848, 1995. 20. Cudd, T.A., Wood, C.E. Does thromboxane A2 mediate the fetal ACTH response to acidemia? Am. J. Physiol. (Regulatory, Integrative Comp. Physiol. 39): R594-R598, 1996. 21. Cudd, T.A., Chen, W.-J.A., West, J.R. Acute hemodynamic and adrenocortical responses to alcohol in adult female sheep. Alcohol. Clin. Exp. Res. 20:1675-1681, 1996. 22. Cudd, T.A., Castellon, R., Purinton, S.C. Thromboxane A2 acts at a site perfused by the carotid vasculature to mediate cardiovascular and adrenocortical responses. Can. J. Physiol. Pharmacol. 75:271-278, 1997. 23. Wood, C.E., Purinton, S., Cudd, T.A. Immunoreactive thromboxane synthase is measurable in ovine fetal hypothalamus as early as 86 days' gestation. Prostaglandins 54: 569-579, 1997. 24. Cudd, T.A. Thromboxane A2 does not act at the carotid sinus to mediate cardiovascular, adrenocorticotropin, cortisol or blood gas responses. Can. J. Physiol. Pharmacol. 76: 118-124, 1998. 25. Cudd, T.A. Thromboxane A2 acts on the brain to mediate hemodynamic, adrenocorticotropin and cortisol responses. Am. J. Physiol. (Regulatory, Integrative Comp. Physiol.) 274: R1353-1360, 1998. 26. Cudd, T.A., Purinton, S., Patel, N. and Wood, C.E. Protective hemodynamic and hormonal actions of hypertonic saline in euvolemic sheep are altered prostaglandin synthase inhibition. Shock 10: 32-36, 1998. 27. Wood, C.E, Barkoe, D., The, A., Newman, H., Cudd, T.A., Purinton, S. and Castro, M.I. Fetal pulmonary immunoreactive adrenocorticotropin: Molecular weight and cellular localization. Regulatory Peptides 73:191-196, 1998.

PHS 398/2590 (Rev. 11/07) Page Biographical Sketch Format Page Principal Investigator: de Figueiredo, Paul

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED TWO PAGES.

NAME POSITION TITLE Paul de Figueiredo Assistant Professor, Faculty of Genetics, Program in Biotechnology, Department of Veterinary Pathobiology, & Department of Plant Pathology and Microbiology

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and ild tdtltii ) DEGREE INSTITUTION AND LOCATION (if YEAR(s) FIELD OF STUDY applicable) Rice University, Houston TX B.A. 1986 Math & Political Sci. Stanford University, Palo Alto CA M.A. 1989 Religious Studies Cornell University, Ithaca NY Ph.D. 1997 Bioch. Mol. Cell Biology MIT, Cambridge MA Postdoc 1998-1999 Vertebrate genetics University of Washington, Seattle WA Postdoc 2000-2005 Microbiology

A. POSITIONS AND HONORS

Positions and Employment 1987-1987 Consultant, Arthur Anderson & Co. 1989-1991 Biologist, NHLBI, National Institutes of Health 2005-present Asst. Professor, Faculty of Genetics, Program in Biotechnology, Department of Veterinary Pathobiology, Department of Plant Pathology and Microbiology, Texas A&M University

Other Experience and Professional Memberships 2005-2007 American Microbiological Society 2005-2007 American Association for the Advancement of Science 2005-2007 American Phytopathological Society 2005-2007 American Society for Cell Biology 2004 Founder, AvanViva, Inc. 2008 Scientific advisory board, ENRQI, Inc. 2008 NSF Review Panel Member, Integrated and Organismal systems (IOS) 2008-present NIH Review Panel Member, Special Emphasis Panel/Scientific Review Group ZRG1 IDM-A, Intracellular bacterial pathogenesis Honors 1982-1986 National Merit Scholar (Rice University) 1988-1989 University Graduate Research Assistantship (Stanford) 1991-1994 NIH Graduate Research Training Grant (Cornell University) 1992 Du Pont Teaching Prize (Cornell University) 1995 Fuertes Writing Prize. (Cornell University) 1995 Biochemistry Teaching Prize (Cornell University) 1995 The American Society for Cell Biology/Hybridon Predoctoral Travel Award 2003 Harvard Biotechnology Business Plan Competition. Runner Up (Harvard Business School) 2003 MIT 50K Business Plan Competition. Semifinalist. (MIT) 2005-present Mexican American and Latino Research Center Fellow (Texas A&M University) 2005-present Alfred P. Sloan Foundation Minority Program Mentor 2006-present Hispanic Leadership Program Mentor

Research Scholar Grant Application 2008-2009

Principal Investigator: de Figueiredo, Paul

2007 Oak Ridge Associated University Junior Faculty Award 2007 Mexican American and Latino Research Center Grantsmanship Award

B. Selected peer-reviewed publications (in chronological order).

1. Banta M. Polizotto RS, Wood SA, de Figueiredo P, Brown WJ. Characterization of a cytosolic activity that induces the formation of Golgi membrane tubules in a cell-free reconstitution system. Biochemistry. 1995 34:13359-66. 2. de Figueiredo P, Drecktrah D, Katzenellenbogen JA Strang M, Brown WJ. Evidence that phospholipase A2 activity is required for Golgi complex and trans Golgi network membrane tubulation. Proc Natl Acad Sci U S A. 1998 95:8642-7. 3. de Figueiredo P, Polizotto RS, Drecktrah D, Brown WJ. Membrane tubule-mediated reassembly and maintenance of the Golgi complex is disrupted by phospholipase A2 antagonists. Mol Biol Cell. 1999 10:1763-82. 4. de Figueiredo P, Drecktrah D, Polizotto RS, Cole NB, Lippincott-Schwartz J, Brown WJ. Phospholipase A2 antagonists inhibit constitutive retrograde membrane traffic to the endoplasmic reticulum. Traffic. 2000 1(6):504-11 5. de Figueiredo P, Doody A, Polizotto RS, Drecktrah D, Wood S, Banta M, Strang MS, Brown WJ. Inhibition of transferrin recycling and endosome tubulation by phospholipase A2 antagonists. J Biol Chem. 2001 276:47361-70. Epub 2001 Oct 03. 6. de Figueiredo P, Roberts R and Nester EW. 2004. DARTs: A DNA-based in vitro polypeptide display technology. Proteomics 2004 4(10) 3128-3140. 7. de Figueiredo P, Terra B., Kaur Anand J., Hikita, T., Sadilek M., Monks DE, Lenskiy A, Hakomori S, and Nester EW. A catalytic carbohydrate contributes to bacterial antibiotic resistance. Extremophiles 2006 Oct 18; [Epub ahead of print] 8. Qin QM, Pei J, Ancona V, Shaw BD, Ficht TA, de Figueiredo P. RNAi screen of endoplasmic reticulum-associated host factors reveals a role for IRE1α in supporting Brucella replication. PLoS Pathog. 2008 Jul 25;4(7):e1000110 9. Hou H., Li L, de Figueiredo P*, and Han A.* Microfabricated Microbial fuel cell arrays reveal electro- chemically active microbes. 2009. PLoS ONE. In press.

• Shared senior authorship

C. Research Support.

Ongoing support 1. NIH 1R21DK078571-01 de Figueiredo (PI) 07.30.2007 to 07.30.2009 NIH/NIDDK Biochemical and molecular analysis of Shwachman-Diamond Syndrome The goal of this project is to develop novel therapeutics for combating Shwachman-Diamond Syndrome, and to elucidate the molecular activities of SBDS, the protein that is mutated in this disease. Role: Project leader

2. NSF0854684 de Figueiredo (PI) 08.15.2009 to 08.14.2011 NSF/CBET “Microbe-mediated electricity generation” The goal of this project is to develop and exploit a new biotechnology platform that supports the massively parallel analysis of electricity generating microbes. Role: Project leader

3. 5R21AI072446-02 de Figueiredo (PI) 02.15.2008 to 02.14.2010 NIH/NIAID Identification and analysis of host factors that support Brucella infection The goal of this project is exploit an insect cell model of Brucella melitensis infection to define host factors that support bacterial entry and replication in host cells. Role: Project leader Research Scholar Grant Application 2008-2009

UUpppdddaaattteeeddd AAppprrriiilll 222000000444 BIOGRAPHICAL SKETCH

NAME DERR, James N. POSITION TITLE Associate Professor

EDUCATION/TRAINING INSTITUTION AND LOCATION DEGREE YEAR FIELD OF STUDY CONFERRED Cameron University B.S. 1980 Biology Sul Ross State University M.S. 1982 Zoology Texas A&M University Ph.D. 1990 Genetics

Professional Experience

1985-1987 Graduate Teaching Assistant, WFSC, TAMU 1987-1989 Tom Slick Research Fellow, WFSC, TAMU 1989-1990 Staff Research Assistant, WFSC, TAMU 1990-1993 Post-Doc Research Associate, ANSC, TAMU 1993-1999 Assistant Professor, VTPB, TAMU 1995- Director, DNA Technologies Laboratory, VTPB, TAMU 1999- Board of Directors, Texas Genetics Society 1999- Associate Professor, VTPB, TAMU 2000-2002 Chair, Graduate Faculty of Genetics, TAMU 2001-2003 President-Elect and President, Texas Genetics Society

Honors and Awards

Phi Kappa Phi Distinguished Alumnus Award, Cameron University, 2000. Outstanding Doctoral Student, Department of Wildlife and Fisheries Sciences, TAMU, 1987-1988. Outstanding Student in Training, The Texas Genetics Society. April, 1987, College Station, Texas. Recipient of the Tom Slick Research Fellowship, by the College of Agriculture, TAMU 1987-1988. President, Association of Graduate Wildlife and Fisheries Scientists, TAMU, 1985-1986.

Publications in the last 5 years and earlier pertinent publications.

Ward, T.J., R. H. Honeycutt and J. N. Derr. 1997. The pattern of nucleotide sequence evolution at Kappa-Casein loci provides evidence of positive selection. Genetics 147:1863-1872 Rooney, A.P., D.B. Merrit and J.N. Derr. 1999. Microsatellite diversity in captive bottlenose dolphins (Tursiops truncatus). Journal of Heredity 90:228-331. Ward, T.J., J. P. Bielawski, S. K. Davis, J. W. Templeton, and J. N. Derr. 1999. Identification of domestic cattle hybrids in wild cattle and bison species: A general approach using mtDNA markers and the parametric bootstrap. Animal Conservation 2:51-57. Rooney, A.P. R.L. Honeycutt, S.K. Davis and J.N. Derr. 1999. Evaluating a putative bottleneck in a population of bowhead whales from patterns of microsatellite diversity and genomic disequilibria. Journal of Molecular Evolution 49:682-690. Green, L.D., J.N.Derr and A. Knight. 2000. Mitochondrial DNA affinities of the peoples of North-Central Mexico. The American Journal of Human Genetics 66:989-998. Schnabel, R.D., T.J. Ward and J.N. Derr. 2000. Validation of 15 microsatellites for parentage testing in North American biosn, Bison bison L. and Domestic cattle. Animal Genetics 31:360-366. Ward, T.J., L.C. Skow, D.S. Gallagher, R.D. Schnabel, C.E. Kolinda, Chad Nall, and J.N. Derr. 2000. Differential introgression of uniparentally-inherited markers in bison populations with hybrid ancestries. Animal genetics 32:89-91. Rooney, A.P., R.L. Honeycutt and J.N. Derr. 2001. Historical Demographics patterns of bowhead whales inferred from genetic polymorphism data. Evolution, 55(8):1678-1685. Arriaga, J.M., N.D. Cohen, J.N. Derr, M.K. Chaffin, and R. J. Martens. 2002. Detection of Rhodococcus equi by polymerase chain reaction using novel, non-proprietary primers. Journal of Veterinary Diagnostic Investigation 14:347-353. Hansen, C., J.N.B. Shrestha, R.J. Parker, G.H. Crow, P.J. McAlpine and J.N. Derr. 2002. Genetic diversity among Canadienne, Brown Swiss, Holstein and Jersey cattle based on 15 microsatellite markers. Genome. 45:862- 870.

Hansen, C., J.N.B. Shrestha, R.J. Parker, G.H. Crow, P.J. McAlpine and J.N. Derr. 2003. Genetic diversity among Canadienne, Brown Swiss, Holstein and Jersey cattle based on mitochondrial D-loop sequence variation. Can. J. Animal Sci. 83: 39-44. UUpppdddaaattteeeddd AAppprrriiilll 222000000444 Seabury, C.M., and J.N. Derr. 2004. Identification of a novel ovine PrP polymorphism and scrapie resistance genotypes for St. Croix White and a related composite breed. Cytogenetic and Genome Research. 102: 85-88. Schnabel, R.D., J.F. Taylor and J.N. Derr. 2004. Development of a linkage map and QTL scan for growth traits in North American bison. Cytogenetic and Genome Research. 102:59-64. Halbert, N., Raudsepp, T., Chowdhary, B., and J.N. Derr. 2004. The legacy of Charles Goodnight: Conservation genetic analysis of the Texas State Bison Herd. Journal of Mammalogy. In Press. Halbert, N.R., W.E. Grant, and J.N. Derr. 2004. Genetic and demographic consequences of importing animals into a small population: A simulation model of the Texas State Bison Herd (U.S.A.). Ecological Modeling, In Press.

Grants in the last 5 years.

1995-2000 Molecular and population genetics of Colombian Criollo cattle. J.N. Derr, S.K. Davis, J.L. Estrada, F. Ariza, J.E. Ossa, A.R. Linares. A proposal for research submitted to the Director of Biotechnology, COLCIENCIAS, Bogota, Colombia. $216.000. 1996-1998 North American bison as a model for the conservation of megavertebrate populations. J.N. Derr (PI) and J.W. Templeton (Co-PI). Agency: National Science Foundation (NSF). $120,000. 1997-1998 JA Ranch bison genetics. J.N. Derr (PI), T. Ward and J. Templeton. Agency: Texas Parks and Wildlife Department, Austin, TX.. $10,000. 1997-1998 A Molecular Genetic Evaluation of the Bering/Chukchi/Beaufort Seas Stock of Bowhead Whales (Balaena mysticetus): An Estimation of Genetic Diversity and Extent of the Potential Recent Bottleneck . J. N. Derr (Principal Investigator) and Alejandro P. Rooney. Department of Wildlife Management, North Slope Borough, Barrow, AK. $56,348. 1997-1998 Comparative molecular and biological characterization of bursal anti-steroidogenic peptide (BASP): Role in reproductive and immune system disease. B. Hargis (PI) T. Porter and J.N. Derr. Agency: CVM Formula Animal Health TAMU. $39,600. 1997-1999 Rhodococcus equi foal pneumonia: Molecular epidemiology, pathogenesis and diagnosis. R. Martens (PI), N. Cohen, K. Chaffin and J.N. Derr. Agency: American Quarter Horse Association. $57,852. 1998-2002 Center for environmental and rural health. Steve Safe, Kenneth Ramos, et al. Agency: National Institutes of Health (NIH-NIEHS) Special Emphasis Panel. $2,000,000. 1998 - 1999 $32,000 (Derr). 1999 Comparative genomics. J. Womack, L. Skow. G. Lees and J. Derr. College of Veterinary Medicine Signature program Enhancement Initiative. $40,000. 1999 Acquisition of real time quantitative PCR capabilities for the CVM. D. Kochevar et.al. College of Veterinary Medicine Signature program Enhancement Initiative. $36,475. 2000-2003 College of Veterinary Medicine Support for the Interdisciplinary Faculty of Genetics. J. Derr. College of Veterinary Medicine Signature program Enhancement Initiative. $15,000. 2000-2003 The Application of Conservation Genetics to the Long-term Management of Bison in Five National Parks. J.N. Derr and J.W. Templeton. Agency: Department of Interior, US Geological Service and the National Park Service. $285,000. 2002 - 2003 Role of the Ft. Niobrara Wildlife Refuge and Sullys Hill Wildlife Preserve in the Long-Term Management of Federal Bison Herds. J.N. Derr PI and J.W. Templeton. The U.S. Department of the Interior, U.S. Geological Survey & the U.S. Fish and Wildlife Service. Total funding $53,000. 2001 – 2003 Banking Bison Tissue Culture Cells for Cloning of Bison in Case of Catastrophic Loss. The Turner Foundation J.W. Templeton PI. Total funding $180,000. 2004 – 2005 Development of a Genetic Based Breeding Program For The Badlands National Park Bison Herd. The Department of the Interior, U.S. J.N. Derr PI. Total funding $50,000.

Significant Research

My research involves applying molecular genetic technology to problems involving conservation genetics, population genetics, gene mapping of economically important traits and the genetics of disease resistance in domesticated livestock and wildlife. Over the last few years my laboratory has investigated these issues in North American bison, domestic cattle, domestic goats, humans, bowhead whales and bottlenose dolphins. Graduate students that have completed their studies through my research program have moved on to private corporations, federal agencies and university positions. FF Principal Investigator/Program Director (Last, first, middle): Patrick W. Dunne BIOGRAPHICAL SKETCH Provide the following information for the key personnel in the order listed on Form Page 2. Photocopy this page or follow this format for each person. NAME POSITION TITLE Patrick W. Dunne Research Assistant Professor EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and including postdoctoral training.) INSTITUTION AND LOCATION DEGREE YEAR(s) FIELD OF STUDY (if applicable) Ohio State University, Columbus, Ohio M.S. 1986 Microbiology Ohio State University, Columbus, Ohio Ph.D. 1988 Molecular Genetics Baylor College of Medicine, Houston, TX Postdoc. 1988-91 Molecular Genetics

RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list in chronological order, previous employment, experience, and honors. Include present membership on any Federal Government public advisory committee. List, in chronological order, the titles and complete references to all publications during the past three years and to representative earlier publications pertinent to this application. DO NOT EXCEED TWO PAGES.

PROFESSIONAL EXPERIENCE: 1991-1996 Instructor, Department of Neurology, Baylor College of Medicine Discovery of CTG expansion in 3’ UTR in a new serine/threonine protein kinase as mutation in the myotonic dystrophy gene. Construction of recombinant DM kinase, biochemical characterization of kinase activity, immunolocalization of DM kinase in skeletal muscle and lens, yeast two-hybrid analysis to identify Raf kinase, PP2A as proteins that directly interact with DM kinase. 1997-1999 Assistant Research Scientist, Dept. of Veterinary Anatomy and Public Health, Texas A&M University. Construction of targeting vectors designed to inactivate the prion protein (PrP) locus and the beta-lactoglobulin locus in bovine fetal fibroblasts, creation and patenting of a BSE-resistant allele of the bovine prion protein gene.. 2000-present Research Assistant Professor, Dept. of Veterinary Anatomy and Public Health, Texas A&M University. Development of enrichment protocols to enhance homologous recombination in primary fetal fibroblasts, patent applications to enhance homologous recombination in somatic cells, generate dominant negative and knock-out BSE-resistant cell lines, development of dominant-negative, prion-resistant deer, elk and goat cell lines, knockdown of FMDV translation by shRNAs, ribozymes in cell culture and animals. 2007-present Principal Investigator, Chimera Transgenics Identification of an alternative translation mechanism in resistance to chemotherapy in a human breast cancer cell model. Development of ESC- and iPSC-derived neural lineages as model systems to test molecular and cellular response to various toxin insults.

HONORS AND MEMBERSHIPS: Neuromuscular Disease Research Fellowship from the Muscular Dystrophy Association; Member, Myotonic Dystrophy Working Group of the MDA, American Association for the Advancement of Science, American Society for Cell Biology, American Society of Human Genetics, Society for the Study of Reproduction, International Embryo Transfer Society.

SELECTED PUBLICATIONS: Dunne, P.W. and Epstein, H.F. 1991. Molecular biology of human muscle disease. Bio/Tech 9: 41-46. PHS 398 (Rev. 4/98) Dunne, P.W., Wang, S-W., Ashizawa, T., Perryman, M.B. and Epstein, H.F. 1992. cDNA surveying of expressed sequences within a subregion of chromosome 19. Genomics 14:863-869. Fu. Y.-W., Pizutti, A., Fenwick, R., King, J., Rajnarayan, S., Dunne, P.W., Dubel, J.R., Nasser, G.A., Ashizawa, T., deJong, P., Wieringa, B., Korneluk, R., Perryman, M.B., Epstein, H.F. and Caskey, C.T. 1992. A sequence scanning method identifies an unstable triplet repeat in a myotonic dystrophy gene, myotonin protein kinase. Science 255: 1256-1258.

(Form Page 6) Page 1

Biographical Sketch- Patrick W. Dunne

Ashizawa, T., Dubel, J.R., Dunne, P.W., Dunne, C.J., Fu, Y-H., Pizzuti, A., Caskey, C.T., Boerwinkle, E., Perryman, M.B., Epstein, H.F. and Hejtmancik, J.F. 1992. Anticipation in myotonic dystrophy: complex relationships between clinical findings and structure of the GCT repeat. Neurology 42: 1877-1883. Dunne, P.W., Walch, E.T. and Epstein, H.F. 1994. Phosphorylation reactions of recombinant human myotonic dystrophy protein kinase and their inhibition. Biochemistry 33: 10809-10814. Figuera, L.E., Dunne, P.W., Pandolfo, M., Cantu, J.M. and Patel, P.I. 1995. Mapping of the congenital generalized hypertrichosis locus to the Xq24-q27.1 region. Nature Genet. 10: 202-207. Dunne, P.W., Ma, L., Casey, D.L., Harati, Y. and Epstein, H.F. 1996 Localization of myotonic dystrophy protein kinase in skeletal muscle and its alteration with disease. Cell Motil. Cytoskel. 33: 52-63. Piedrahita, J.A., Dunne, P.W., Lee, C-K., Moore, K., Rucker, E. and Vasquez, J.C. 1999. Use of embryonic and somatic cells for production of transgenic domestic animals. Cloning 1: 73-87. Shimizu, M., Wang, W., Walch, E.T., Dunne, P.W. and Epstein, H.F. 2000. Rac-1 and Raf-1 kinases, components of distinct signaling pathways, activate myotonic dystrophy protein kinase. FEBS Letters 475(3): 273-7. Dunne, P.W. and Piedrahita, J.A. 2002. Genetic engineering and cloning. In “Principles of Cloning” (J.B. Cibelli, R. Lanza, K. Campell, M.D. West, Eds.) Academic Press, San Diego.

SELECTED RECENT PUBLICATIONS: V. S. Venkatraj1, T. S. Bhari1, M. Roula1, R. Burghardt1, J. M. Pry1, K. W. Stone1, U. Venkatraj, I. Villareal2, E.Castiglioni1, R. Pai1, P W Dunne. 2007. Molecular Interplay Between Alternatively Translated Genes and Calcium Signaling During Chemotherapy. Annual AACR Meeting. Zaunbrecher G, Dunne PW, Mir, B, Breen M, Piedrahita JA. 2008. Enhancement of extra chromosomal recombination in somatic cells by affecting the ratio of homologous recombination (HR) to non-homologous end joining (NHEJ). Animal Biotechnology. 19:6-21.

SELECTED PRIOR RESEARCH SUPPORT Advanced Technology Program. State of Texas. Generating Conditional FMDV Resistance in Cattle by Inducible Ribozyme Degradation of IRES RNA. 2002-2004 The goal of this study is to develop inducible resistance to the foot and mouth virus in cloven-hoofed animals using antisense technology. Role: PI In2Gen, Inc. Generation of Transgenic Farm Animals Producing Recombinant Human Proteins. 2002-2005 The goal of this work is to isolate and characterize promoters for development of transgenic farm animals that can serve as bioreactors. Role: PI Advanced Research Program. State of Texas “Enhancement of homologous recombination in primary mammalian cells” 2000-2002 The goal of this study is to discover how genetic manipulation of several key enzymes in the cell cycle upregulate homologous recombination in primary fibroblasts. Role: Co-PI Advanced Technology Program, State of Texas “Production of transgenic cattle by cloning with primordial germ cells.” 1998-2000. The goal of this research was to test the feasibility of generating transgenic cattle by somatic cell nuclear transfer using prion protein modification as target locus. Role: Co-PI

Curriculum Vitae: M. Nurul Islam-Faridi Research Geneticist PI, Forest Tree Molecular Cytogenetics Southern Institute of Forest Genetics US Forest Service Associate Professor (adjunct) Dept. of Ecosystem Science & Management Texas A&M University College Station, TX 77843-2585 Tel: 979-862-3908; Fax: 979-845-3272

A. Personal Data

A1. Educational Background

a. College Degrees

• Ph.D. (1988): Genetics/Cytogenetics University of Cambridge and Plant Breeding Institute, Cambridge, England, UK • M.Phil. (1984): Plant Breeding University of Cambridge and Plant Breeding Institute, Cambridge, England, UK • M.Sc.Ag. (1982): Agricultural Chemistry Bangladesh Agricultural University, Mymensingh, Bangladesh • M.Sc.Ag. (1979): Genetics and Plant Breeding Bangladesh Agricultural University, Mymensingh, Bangladesh • B.Sc.Ag. (Hons.) (1977): Major in Genetics and Plant Breeding Bangladesh Agricultural University, Mymensingh, Bangladesh

b. Non-Degree / Training

• Radiation safety course for handling 32P, Philippines Nuclear Research Institute, Manila, Philippines (August 1989), and Texas A&M, College Station, TX (March 1997). • Managing Success in Scientific Research, Research Management Center, University of the Philippines, LosBanos, Philippines (March-May 1990).

A2. Professional Experience

2003 – present Research Geneticist, SRS RU-4160 (SRS-4153 until Station realignment, April 2007), Southern Institute of Forest Genetics, College Station, TX 1998 – 2003 Assoc. Research Scientist, Dept of Soil & Crop Sciences, Texas A&M University, College Station, TX 1994 – 1998 Asst. Research Scientist, Dept of Soil & Crop Sciences, Texas A&M University, College Station, TX 1993 – 1994 Assoc. Scientist, Maize Program, Intl. Maize & Wheat Research Institute, Mexico 1991 – 1993 Post Doctoral Scientist, Maize Program, Intl. Maize & Wheat Research Institute, Mexico 1988 – 1991 Post Doctoral Scientist, Dept. of Plant Breeding, Intl. Rice Research Institute, Philippines 1983 – 1988 Graduate Research Assistant, Plant Breeding Institute/University of Cambridge, Cambridge, England, UK 1981 – 1983 Asst. Professor, Dept. of Genetics & Plant Breeding, Bangladesh Agricultural University, Mymensingh, Bangladesh 1977 – 1981 Teaching Fellow & Lecturer, Dept. of Genetics & Plant Breeding, Bangladesh Agricultural University, Mymensingh, Bangladesh

B. Professional Activities and Recognition

B1. Honors and Awards

2008 Certificate of Merit, for co-leading the SRS into forest tree genomics with specific contributions in publishing the poplar genome and the loblolly pine reference karyotype, 2007–2008. 2006 Certificate of Merit, for setting up a new Forest Tree Molecular Cytogenetics Laboratory, College Station, TX, 2005–2006. 2004 Plant FISH Preparation Award, 1st position, Applied Imaging Worldwide Calendar Competition, Applied Imaging Inc., UK. 2001 Plant FISH Preparation Award, 2nd position, Applied Imaging Worldwide Calendar Competition, Applied Imaging Inc., UK. 1998 Collaborative Research Award, Dept. of Soil & Crop Sciences, Texas A&M University, TX. 1987 Research Award, for developing Glu-U1 recombinant wheat lines, Agricultural Genetics Company, Cambridge, UK. 1987 Frank Horne Research Award, University of Cambridge, Cambridge, UK. 1987 Smart Memorial Award, University of Cambridge, Cambridge, UK. 1985-86 Overseas Research Studentship, University of Cambridge, Cambridge, UK. 1984 T.H. Middleton Prize, for distinction & first position in M.Phil. Exam., Dept. of Applied Biology, University of Cambridge, Cambridge, UK. 1983-87 Cambridge Commonwealth Trust Scholarship, University of Cambridge, Cambridge, UK. 1973-77 Awarded talent pool scholarship, Bangladesh Agricultural University, Mymensingh, Bangladesh.

JANUARY 2009 CURRICULUM VITAE

NAME: Edward A. Funkhouser Executive Director Prof. of Biochem. & Biophys. and Honors Programs and Academic Scholarships of Molecular & Environ. Plant Science Texas A&M University Department of Biochemistry & Biophysics College Station, TX 77843-4233 Texas A&M University, College Station, TX 77843-2128 Tel: (979) 845-6774 Tel: (979) 845-8271 FAX: (979) 845-0300 FAX: (979) 845-9274 Email: [email protected]

DATE OF BIRTH: 30 September 1945 (Trenton, New Jersey, USA)

EDUCATION: B.S. (Horticulture), Delaware Valley College of Science and Agriculture, 1967 M.S. (Plant Physiology), Rutgers University, 1969. Graduate Advisors: Drs. H. E. Clark and C. A. Price Ph.D. (Plant Physiology), Rutgers University, 1972. Graduate Advisor: Dr. C. A. Price

PROFESSIONAL EXPERIENCE AND ACADEMIC APPOINTMENTS:

2000 - Present Executive Director, Honors Programs and Academic Scholarships 1999 - 2000 Interim Executive Director, Honors Programs and Academic Scholarships 1997 1999 Associate Director, Honors Programs and Academic Scholarships 1996 1997 Interim Associate Director, Honors Programs and Academic Scholarships 1994 - Present Professor of Biochemistry & Biophysics and of Plant Physiology & Plant Biotechnology. 1994 - 2000 Director, Howard Hughes Medical Institute-Undergraduate Intern Program, TAMU 1990 1997 Associate Head for Undergraduate Programs, Department of Biochemistry & Biophysics 1983 - 1994 Associate Professor of Biochemistry and Biophysics and of Plant Physiology and Plant Biotechnology. Texas A&M University 1986 Visiting Scientist with Dr. Jochim Messing. Waksman Institute of Microbiology, Rutgers University (Academic Development Leave) 1982 - 1983 Associate Professor of Plant Physiology. Texas A&M University 1981 Visiting Investigator. Waksman Institute of Microbiology, Rutgers University 1979 Visiting Scientist. Forschungsstelle Vennesland der Max-Planck-Gesellschaft 1976 - 1982 Assistant Professor of Plant Physiology. Texas A&M University 1974 - 1976 Wissenschaftlicher Assistent. Forschungsstelle Vennesland der Max-Planck-Gesellschaft (with Dr. Birgit Vennesland), West Berlin, FRG 1972 - 1974 Research Associate. Dept. of Biology, SUNY Buffalo (with Dr. F. A. Loewus) 1969 - 1972 Instructor of Biology, Mathematics, and Biochemistry, Delaware Valley College

ACADEMIC ACTIVITIES AND RECOGNITION:

Current Courses Taught: AGLS 125 Cultural Exploration: Immersion in and Refection of a Non-American Culture (A Century Scholar Learning Community Provost’s Office Diversity Award – Group – Office of Honors Programs and Academic Scholarships Distinguished Alumnus Award-Plant Science, Delaware Valley College (1999) Ed Guthrie Award, Advising TAMU (1996) Diversity Award - Individual Effort, Office of Associate Provost & Dean of Faculties, TAMU (1994) Diversity Award, Multicultural Services, TAMU (1992) Outstanding Faculty Member (Undergraduate Biochemistry Society) (1989) Faculty Distinguished Achievement Award in Teaching TAMU (1988) Award in Excellence in Undergraduate Teaching, TAMU System (1988) Academic Study Leave, TAMU (1986) Incentive in Excellence, Center for Teaching Excellence (TAMU) (1985, 1989) Travel Grants from Max Planck Society (1979, 1981) NIH Trainee. Physiology Course, Marine Biological Laboratory. Woods Hole, MA (1972) NIH Postdoctoral Felllow with Dr. Frank Loewus (1972-1974) Highest Grade-Point-Ratio in graduating class, Delaware Valley College (1967) James Work Award (Senior for an outstanding paper), Delaware Valley College (1967) President Local Chapter Delta Tau Alpha (National Agricultural Honor Society) (1966-1967) Berstein Award (Freshman with highest Grade-Point Ratio), Delaware Valley College (1964) Undergraduate Scholarship (Tuition and Fees), Delaware Valley College (1963-67) E. A. Funkhouser 12/7/2009 Page 2

TEACHING AND ACADEMIC INITIATIVES:

Teaching Academy, Mentor,( 1999-Present Teaching Academy, Center for Teaching Excellence (1998-Present) Co-Chair, TAMU Student Research Week, (1998 – 2001) Chair, Faculty Steering Committee for Professional Program in Biotechnology (1998-2001) Gamma Sigma Delta (Honor Society), Historian (1993-94), Secretary 19(94-95), Pres. Elect. (1995-96) Pres. (1996-97) Past Pres. (1997-98, 1998-99). TAMU Chapter of Sigma Xi, President (2000-01) Vice President (1999-00), Membership Secretary (1993-99) Chair, Awards Committee (1991-92), Member (1990-present) TAMU Chapter of Phi Kappa Phi (Honor Society), Public Relations (98-99), Treasurer (99-01), President (01-02) Science and Education Section, SWARM, AAAS (Chair, 1991-92; Vice Chair, 1990-91) Plant Science Section, SWARM, AAAS (Vice Chair, 1996-97) Director, Anakletic Laboratory Prgram in the Sciences (ALPS) (1996- 1999) Director for NIH Minority Student Apprentice Program (1989-95) Director for Lab Start (1989-95) South. Sect. Amer. Soci. Plant Physiol. (Chair, 1992-93; Vice Chair, 1991-92; Secretary/Treasurer, 1990-91) Chair, Core Curriculum Oversight Committee, Faculty Senate (1990-1991) Chair, Search Committee, Director of the Center for Teaching Excellence (1990 -1991) Member, Sigma Xi Workshop on Entry-Level Undergraduate Courses. (1990) Caucus Leader, COALS, Faculty Senate, TAMU. (1989-1990) Chair, Graduate Awards Committee, South. Section, Am. Soc. of Plant Physiol. (1989) Chair, Faculty Advisory Committee, COALS, TAMU. (1988-89) Awards received by students: Best-Graduate-Research-Paper award, Southern Section of the American Society of Plant Physiologists (1982); Amoco Graduate Student Teaching Award (1983); ACS Graduate Student Teaching Award (1986). Developed laboratory manual for Plant Physiology (1984, 1987, 1992) Member, Executive Committee, Faculty of Plant Physiology, TAMU. (1983-1989) Initiated , coordinated, and taught several couses in Survey Series in Plant Physiology (PPHY 671, 672, 673, 674, 675, 676, 677, 678) Developed graduate course in Plant Physiology (PPHY 602) (1977-1985)

RECENT SUPPORT:

Summer Enrichment Program. Center for Academic Enhancement. 1990 - 2000. $6,000/year. COALS Minority Scholars Program. USDA. 1994-1999. $80,000 (with $20,000 matching) Anakletic Laboratory Program in the Sciences (ALPS). NIH. 1996-2000. $100,440. Minority High School Student Research Apprentice Program. NIH. 1989-1995, $164,000. Undergraduate Research Intern Program. Howard Hughes Medical Institute. 1994-2000. $1,700,000. Project Director. Research Experiences for Women and Minorities. 1995-97 Abbott Laboratories. $5,000. Minority High School Student Research Apprentice Program. TAES. 1996. $2,000; 1995. $ 2,000; 1994, $ 6,000; 1993, $6,000; 1992, $6,000; 1991, $4,000; 1990, $2,000. Minority High School Student Research Apprentice Program. Monsanto Chemical Company. 1995, $2,000; 1994, $ 2,000; 1993, $2000. Pine -tree Improvement: Expanding current advances in Biotechnology. 1993-1998. $ 350,000 Co-PI with R. J. Newton, J. Cairney, and H. van Buijtenen. Texas Biotechnology Teacher Enhancement Project. NSF. 1992-97, $1,604,319 Co-PI with R. James, D. Pettigrew, C. Patterson.

PUBLICATIONS: (31 refereed, 3 proceedings, 4 book chapt., 3 laboratory manuals, 49 abstracts)

E. A. Funkhouser and S. V. Burgoon. 1999. Can less be more? In Reshaping Undergraduate Science and Engineering Education: Tools for Better Learning. Sigma Xi Forum. Nov. 4-5, 1999. Page 145 J. Chen, A. R. Reinsch. L. S. Adair, R. T. Newton, E. A. Funkhouser, and J. Cairney. 1996. Isolation, sequence and expression analysis of two water-deficit-induced cDNA clones from the halophyte Atriples canescens (saltbush). Physiol. Plant. 96:401-410. S. Chang, J. D. Dias, E. A. Funkhouser, R. J. Newton, and J. Cairney. 1995. Gene expression under water deficit in loblolly pine (Pinus taeda L.): Isolation and characterization of cDNA clones. Physiol. Plant. 97:139-148 T. S. Artlip and E. A. Funkhouser. 1994. Protein synthetic responses to environmental stresses. In Handbook of Plant and Crop Physiology. M. Pessarakli Ed., pp 627-644.

Principal Investigator/Program Director (Last, First, Middle):

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Gastel, Barbara Jean Professor of Veterinary Integrative Biosciences and eRA COMMONS USER NAME of Humanities in Medicine

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) Yale University B.A. 1974 Biology/Medical History Johns Hopkins School of Medicine M.D. 1978 Medicine Johns Hopkins School of Public Health M.P.H. 1978 Public Health

NOTE: The Biographical Sketch may not exceed four pages. Follow the formats and instructions on the attached sample.

A. Positions and Honors

Positions and Employment 1978-1980 Special Assistant, Office of the Director, National Institute on Aging, NIH, Bethesda, MD 1980-1981 Special Assistant to the Director, National Center for Health Care Technology, Rockville, MD 1981-1983 Assistant Professor of Science Writing, Massachusetts Institute of Technology, Cambridge, MA 1983-1985 Visiting Professor of Technical Communication, Beijing Medical University (now Peking University Health Science Center), Beijing, China 1985-1989 Assistant Dean for Teaching, University of California, San Francisco School of Medicine 1989-2004 Associate Professor of Journalism and of Humanities in Medicine, Texas A&M University, College Station, TX 2004- Associate Professor of Veterinary Integrative Biosciences and of Humanities in Medicine, Texas A&M University, College Station, TX 2008- Professor of Veterinary Integrative Biosciences and of Humanities in Medicine, Texas A&M University, College Station, Texas

Other Experience 1978 AAAS Mass Media Fellow, Newsweek, New York, NY 1995-1999, Coordinator, Master’s Degree Program in Science and Technology Journalism, Texas A&M 2004- University 1996-2007 US Coordinator, China Medical Board of New York Training Program in Biomedical Writing and Editing 1998-1999 Editor, CBE Views (periodical of the Council of Science Editors) 2000- Editor, Science Editor (periodical of the Council of Science Editors) 2007- Knowledge Community Editor, AuthorAID @ INASP (www.authoraid.info), International Network for the Availability of Scientific Publications

Professional Memberships American Association for the Advancement of Science American Medical Writers Association

PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Biographical Sketch Format Page Association of Health Care Journalists Council of Science Editors National Association of Science Writers World Association of Medical Editors

Honors 1973 Phi Beta Kappa 1991 Fellow, American Medical Writers Association 1993 Golden Apple Award, American Medical Writers Association 1998 Harold Swanberg Distinguished Service Award, American Medical Writers Association 2001 Fellow, American Association for the Advancement of Science 2002 Distinguished Service Award, Council of Science Editors 2006 Honored Editor in the Life Sciences, Board of Editors in the Life Sciences

B. Selected peer-reviewed [and other] publications (in chronological order).

Selected Peer-Reviewed Articles 1. Gastel B. Measles: A potentially finite history. J Hist Med Allied Sci 1973;28:34-44. 2. Gastel B, Cornoni-Huntley J, Brody JA. Estrogen use and postmenopausal women: A basis for informed decisions. J Fam Pract 1980;11:851-60. 3. Gastel B. Teaching biomedical communication in China: Reflections on two years’ experience. CBE Views 1987;10:19-21. 4. Gastel B, Weng YQ. Medical journals in China. Ann Intern Med 1990;112:70-2. 5. Gastel B. An award program for teaching excellence. Acad Med 1991;66:192-3. 6. Gastel B. Medical writers’ visit to China and Mongolia: Delegation leader’s diary. AMWA J 1996;11(2):19- 25. 7. Gastel B. Teaching key groups to communicate science to nonspecialists. CBE Views 1997;20:82-5. 8. Gastel B. Hosting a biomedical communication intern: From idea through implementation. AMWA J 2006;21:97-101.

Books (most recent editions) 1. Gastel B. Presenting Science to the Public. ISI Press, 1983. 2. Gastel B. Teaching Science: A Guide for College and Professional School Instructors. Oryx Press, 1991. 3. Gastel B. Health Writer’s Handbook. 2nd ed. Blackwell Publishing, 2005. 4. Day RA, Gastel B. How to Write and Publish a Scientific Paper. 6th ed. Greenwood Press, 2006.

Selected Other Publications 1. Gastel B. A strategy for reviewing books for journals. BioScience 1991;41:635-7. (reprinted: CBE Views 1993;16:50-2; Plant Sci Bull 1994;40:79-81) 2. Gastel B. Working with Your Older Patient: A Clinician’s Handbook. Bethesda, MD: National Institute on Aging, 1994. 3. Gastel B. Teaching techniques: theory and practice. In: Witte FM, Taylor ND, eds. Essays for Biomedical Communicators: Volume 2 of Selected AMWA Workshops. Bethesda, MD: American Medical Writers Association, 1997:212-21. 4. Gastel B. Assessing the impact of investigators’ work: beyond impact factors. Can J Anaesth 2001; 48:941-5. 6. Gastel B. Review of: Hyping Health Risks: Environmental Hazards in Daily Life and the Science of Epidemiology. N Engl J Med 2009;360:548-9. (Also more than 50 other books reviews, including 13 in N Engl J Med) 7. Gastel B. Medical journalism. In: Priest SH, ed. Encyclopedia of Science and Technology Communication. Thousand Oaks, CA: SAGE Publications (in press). 8. Gastel B. Editing within the pure sciences. In: Murphy AJ, ed. New Perspectives on Technical Editing. Amityville, NY: Baywood Press (in press).

PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page 2 Biographical Sketch Format Page

Dr. Terry J. Gentry

Current Title: Assistant Professor

Appointment: 70% Research, 30% Teaching

Physical Address:

550A Heep Center, Texas A&M University, College Station, Texas 77843-2474

Email Address: mailto:[email protected]

Education:

Ph.D., Microbiology & Immunology, University of Arizona, 2003 M.S., Agronomy (Soil Microbiology), University of Arkansas, 1998 B.S., Agronomy, University of Arkansas, 1993

Teaching Focus:

Environmental Soil Science (AGRO 455)

Research & Extension Focus:

The development and use of molecular technologies to enable the detection and remediation of environmental contamination. This includes the detection and identification of microbial pathogens from animal, human, and natural sources and also the characterization of microbial populations and communities contributing to applied remediation processes such as the bioremediation of organic and metal contaminants.

Publications. Refereed journal publications – 16, Book chapters – 3, Other technical publications – 2

Professional Accomplishments (limit to bullet statements):

• Developed a bioremediation functional gene microarray containing over 12,500 probes for microbial genes involved in the degradation of organic contaminants and the resistance to, or reduction of, various metals. This was part of team effort that produced an array containing >23,000 probes for microbial genes involved in C, N, and S cycling, methane oxidation, methanogenesis, organic contaminant degradation, metal resistance, and perchloroate remediation. • Used microarray technology to correlate microbial community dynamics with geochemical parameters during in situ remediation of uranium- and nitrate-contaminated soil and groundwater. • Used metagenomic approaches to characterize genomes of dominant microbial populations in contaminated groundwater. • Conducted research investigating the exchange of DNA among soil bacteria following exposure to organic contaminants and the potential application of this process to enhance the remediation of contaminated sites. • Constructed a mobilizable plasmid containing genes for 2-chlorobenzoate degradation, nickel resistance, and the green fluorescent protein (GFP) for use in horizontal gene transfer experiments.

Recent Publications (limit to 10 most recent):

1. Gentry, T.J., and J. Zhou. 2006. Microarray-based microbial identification and characterization. In Y.-W. Tang and C. Stratton (ed.) Advanced Techniques in Diagnostic Microbiology. Kluwer Publishers (in press).

2. Hwang, C., W.-M. Wu, T.J. Gentry, J. Carley, S.L. Carroll, C. Schadt, D. Watson, P.M. Jardine, J. Zhou, R.F. Hickey, C.S. Criddle, and M.W. Fields. 2006. Changes in microbial community structure correlate with stressed operating conditions during start-up of a field-scale denitrifying fluidized bed reactor. Appl. Microbiol. Biotech. (in press).

3. Krutz, L.J., T.J. Gentry, S.A. Senseman, I.L. Pepper, and D.P. Tierney. 2006. Mineralization of atrazine, metolachlor, and their respective metabolites in vegetated filter strip and cultivated soil. Pest Manag. Sci. (in press).

4. Wu, W., J. Carley, T.J. Gentry, M.A. Ginder-Vogel, M. Fienen, T. Mehlhorn, H. Yan, S. Carroll, M.N. Pace, J. Nyman, J. Luo, M.E. Gentile, M.W. Fields, R.F. Hickey, B. Gu, D. Watson, O.A. Cirpka, J. Zhou, S. Fendorf, P. Kitanidis, P.M. Jardine, and C.S. Criddle. 2006. Field-scale bioremediation of uranium in a highly contaminated aquifer II: reduction of U(VI) and geochemical control of U(VI) bioavailability. Environ. Sci. Technol. (in press).

5. Krutz, L.J., C.A. Beyrouty, T.J. Gentry, D.C. Wolf, and C.M. Reynolds. 2005. Selective enrichment of a pyrene degrader population and enhanced pyrene degradation in Bermuda grass rhizosphere. Biol. Fert. Soils. 41:359- 364.

6. Schadt, C.W., J. Liebich, S.C. Chong, T.J. Gentry, Z. He, H. Pan, and J. Zhou. 2005. Chapter 11, Design and use of functional gene microarrays (FGAs) for the characterization of microbial communities, p. 331-368. In T. Savidge and H. Pothulakis (ed.) Microbial Imaging. Methods in Microbiology. Vol. 34. Academic Press, Inc., London, UK.

7. Gentry, T.J., K.L. Josephson, and I.L. Pepper. 2004. Functional establishment of introduced chlorobenzoate degraders following bioaugmentation with newly activated soil. Biodegradation 15:67-75.

8. Gentry, T.J., C. Rensing, and I.L. Pepper. 2004. New approaches for bioaugmentation as a remediation technology. Crit. Rev. Environ. Sci. Technol. 34:447-494.

9. Gentry, T.J., G. Wang, C. Rensing, and I.L. Pepper. 2004. Chlorobenzoate-degrading bacteria in similar pristine soils exhibit different community structures and population dynamics in response to anthropogenic 2-, 3-, and 4- chlorobenzoate levels. Microb. Ecol. 48:90-102.

10. Wang, G., T.J. Gentry, G. Grass, K.L. Josephson, C. Rensing, and I.L. Pepper. 2004. Real-time PCR quantification of a green fluorescent protein-labeled, genetically engineered Pseudomonas putida strain during 2- chlorobenzoate degradation in soil. FEMS Microbiol. Lett. 233:307-314.

Professional Memberships, Leadership Roles and Honors:

• American Society for Microbiology • American Society of Agronomy • Soil Science Society of America • Superfund Basic Research Program Graduate Trainee, 2002-2003 • University of Arizona Foundation Outstanding Teaching Associate Award, 2002 • ARCS Foundation Fellowship, 2000-2002 • Graduate Registration Scholarship, University of Arizona, 2000-2002 • College of Medicine Fellowship, University of Arizona, 2000-2002 • Outstanding M.S. Student, Agronomy Department, University of Arkansas, 1997 • First place graduate student slide presentation, Southern Branch ASA Meetings, 1997 • First place graduate student poster presentation, Southern Branch ASA Meetings, 1996

Principal Investigator/Program Director (Last, First, Middle): Clare A. Gill

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Clare A. Gill Associate Professor eRA COMMONS USER NAME

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) Flinders University of South Australia, Australia BBiotech 1994 Biotechnology University of Adelaide, Australia PhD 2000 Animal Molecular Genetics Texas A&M University Post-Doc 1999 Animal Genomics

A. Positions and Honors.

Positions and Employment 1995 - 1998: Graduate Student; University of Adelaide, South Australia, Australia. 1999 - 2000: Post-Doctoral Fellow; Texas A&M University. 2000 - 2001: Associate Research Scientist; Texas A&M University. 2001 - present: Member of the Graduate Faculty, Texas A&M University. 2001 - 2007: Assistant Professor of Animal Genomics; Texas A&M University. 2002 - present: Member of the Interdisciplinary Faculty of Genetics, Texas A&M University. 2003 - present: Member of the Interdisciplinary Faculty of Biotechnology, Texas A&M University. 2007 - present: Associate Professor of Animal Genomics; Texas A&M University.

Other Experience and Professional Memberships 1996-present: International Society of Animal Genetics 2001-present: Member, Regional project NC-1010 (secretary 2005-2006; president 2006-2007) 2001-present: Member, Regional project NRSP-8 (secretary 2005-2006; president 2006-2007) 2002-2007: Member, bovine BAC map consortium steering committee 2002-present: Member, bovine genome sequencing project technical committee 2003-present: American Society of Animal Science 2003-2004: Chair, Scientific Advisory Board, Bovigen LLC 2003-2006: Editorial board, Journal of Animal Science 2004-2007: Section Editor, Journal of Animal Science 2005-present: Team leader, international bovine HapMap consortium 2007-present: Team leader, bovine genome sequence annotation (behavior and maternal nurturing)

Honors 1995: AMGEN Australia prize for excellence in biotechnology research 1995: Flinders University Chancellor’s letter of commendation 1995 - 1997: International Wool Secretariat Ph.D. scholarship 1998 & 1999: Finalist in the Young Australian of the Year Awards: nominated for The SA Water Science and Technology award for outstanding achievement

PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Biographical Sketch Format Page Principal Investigator/Program Director (Last, First, Middle): Clare A. Gill

B. Selected peer-reviewed publications (2006-2009).

1. Wunderlich, K. R., C. A. Abbey, D. R. Clayton, Y. B. Song, J. Schein, M. Georges, W. Coppieters, D. L. Adelson, J. F. Taylor, S. L. Davis, and C. A. Gill. 2006. A 2.5 Mb contig constructed from Angus, Longhorn and horned Hereford DNA spanning the polled interval on bovine chromosome 1. Anim. Genet. 37: 592-594. 2. Hansen, G. R., C. A. Abbey, D. P. Gaile, T. Raudsepp, B. P. Chowdhary, J.E. Womack, and C. A. Gill. 2007. Assignment of six genes to bovine chromosomes 5 and 16 by fluorescence in situ hybridization, radiation hybrid mapping and genetic linkage analysis. Cytogenet. Genome Res. 116:194-197. 3. Amen, T. S., A. D. Herring, J. O. Sanders, and C. A. Gill. 2007. Evaluation of reciprocal differences in Bos indicus x Bos taurus backcross calves produced through embryo transfer: I. Birth and weaning traits. J. Anim. Sci. 85: 365-372. 4. Amen, T. S., A. D. Herring, J. O. Sanders, and C. A. Gill. 2007. Evaluation of reciprocal differences in Bos indicus x Bos taurus backcross calves produced through embryo transfer: II. Postweaning, carcass, and meat traits. J. Anim. Sci. 85: 373-379. 5. Van Eenennaam, A. L., J. Li, R. M. Thallman, R. L. Quaas, M. E. Dikeman, C. A. Gill, D. Franke, and M. G. Thomas. 2007. Validation of commercial DNA tests for quantitative beef traits. J. Anim. Sci. 85:891- 900. 6. McKay, S. D., R. D. Schnabel, B. M. Murdoch, J. Aerts, C. A. Gill, C. Gao, C. Li, L. K. Matukumalli, Z. Wang, C. P. Van Tassell, J. L. Williams, J. F. Taylor, and S. S. Moore. 2007. High-throughput genotyping facilitates rapid construction of whole genome radiation hybrid and linkage maps. Anim. Genet. 38:120- 125. 7. McKay, S. D., R. D. Schnabel, B. M. Murdoch, L. K. Matukumalli, J. Aerts, W. Coppieters, D. Crews, E. D. Neto, M. Georges, C. A. Gill, C. Gao, H. Mannen, Z. Wang, C. P. Van Tassell, J. L. Williams, J. F. Taylor, and S. S. Moore. 2007. Whole genome linkage disequilibrium maps in cattle. BMC Genetics 8:74. 8. Seabury, C. M., C. A. Gill, J. W. Templeton, J. B. Dyar, J. N. Derr, D. L. Adelson, E. Owens, D. S. Davis, D. C. Kraemer, and J. E. Womack. 2007. Molecular characterization of the Rocky Mountain Elk (Cervus elaphus nelsoni) PRNP putative promoter. J. Heredity 98: 678-686. 9. Snelling, W. M., R. Chiu, J. E. Schein, M. Hobbs, C. A. Abbey, D. L. Adelson, G. L. Bennett, I. E. Bosdet, M. Boussaha, R. Brauning, A. R. Caetano, M. M. Costa, A. M. Crawford, B. P. Dalrymple, A. Eggen, A. Everts-van der Wind, S. Floriot, M. Gautier, C. A. Gill, R. D. Green, R. Holt, S. J. M. Jones, S. M. Kappes, J. W. Keele, P. J. de Jong, D. M. Larkin, H. A. Lewin, J. C. McEwan, S. McKay, S. McWilliam, M. A. Marra, C. A. Mathewson, L. K. Matukumalli, S. S. Moore, B. Murdoch, F. Nicholas, K. Osoegawa, A. Roy, H. Salih, L. Schibler, R. Schnabel, L. Silveri, L. C. Skow, T. P. L. Smith, T. S. Sonstegard, J. Taylor, R. Tellam, C. P. Van Tassell, J. L. Williams, J. E. Womack, N. H. Wye, G. Yang, S. Zhao. 2007. A physical map of the bovine genome. Genome Biol. 8: R165. 10. Rodrigues Filho, E. A., N. B. Stafuzza, A. R. Caetano, C. A. Gill, P. K. Riggs, J. E. Womack, ad M. E. J. Amaral. 2008. Mapping MHC genes in River Buffalo. In: Pinard, M-H., C. Gay, P.-P. Pastoret, and B. Dodet (eds): Animal Genomics for Animal Health Dev. Biol. (Basel). Basel, Karger. 138:343-346. 11. McKay, S. D., R. D. Schnabel, B. M. Murdoch, L. K. Matukumalli, J. Aerts, W. Coppieters, D. Crews, E. D. Neto, C. A. Gill, C. Gao, H. Mannen, Z. Wang, C. P. Van Tassell, J. L. Williams, J. F. Taylor, and S. S. Moore. 2008. An assessment of population structure in eight breeds of cattle using a whole genome SNP panel. BMC Genetics 9:37. 12. Goldammer, T., R. M. Brunner, A. Rebl, C. H. Wu, K. Nomura, T. Hadfield, C. Gill, B. P. Dalrymple, J. E. Womack, N. E. Cockett. 2009. A high resolution radiation hybrid map of sheep chromosome X and comparison with human and cattle. Cytogenet. Genome Res. 125: 40-45. 13. The Bovine Genome Sequencing and Analysis Consortium. 2009. The genome sequence of taurine cattle: A window to ruminant biology and evolution. Science 324: 522-528. 14. The Bovine HapMap Consortium. 2009. Genome-wide survey of SNP variation uncovers the genetic structure of cattle breeds. Science 324: 528-532. 15. Villa-Angulo, R., L. Matukumalli, C. Gill, J. Choi, C. Van Tassell, and J. Grefenstette. 2009. High- resolution haplotype block structure in the cattle genome. BMC Genetics 10: 19.

PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page 2 Continuation Format Page Department of Ecosystem Science and Management Vita – J. Gould

CURRICULUM VITAE Jean H. Gould January, 2009

Title Associate Professor, Plant Cell Biology, non-tenure track

Address Department of Ecosystem Science and Management, Room 305 Horticulture/Forest Science Building Texas Agricultural Experiment Station, Texas A&M University College Station, Texas 77843-2138

Phone (979) 845-5078

E-Mail [email protected]

EDUCATION Ph.D. 1980 Plant Physiology, University of California – Riverside, Toshio Murashige, Advisor.

POSITIONS HELD AND APPOINTMENTS TAES/TAMU Academic Positions 2004-P Associate Professor, Research, Ecosystem Science & Management Dept. (formerly Department of Forest Science) 1998-04 Assistant Professor, Research, Department of Forest Science 1993-98 Associate Research Scientist, Department of Forest Science 1988-92 Associate Research Scientist, Department of Soil and Crop Sciences 1987-88 Postdoctoral Research Associate, Department of Soil and Crop Sciences 1980-87 Postdoctoral Research Associate, Department of Botany & Plant Sciences, UC Riverside, W. M. Dugger, Supervisor. 1974-1980 Research Assistant, Department of Botany & Plant Sciences, UC Riverside

Faculty Associations 2006-P Chair, Molecular & Environmental Plant Sciences (MEPS) interdisciplinary graduate program 2008-P Vegetable & Fruit Improvement Center (VFIC) 2000-P Adjunct, Department of Horticultural Sciences (HORT) 1997-P Faculty of Genetics (GENE)

RESEARCH PROJECTS (Hatch TEX8458) ‘Improvement of Crop Plants and Forest Trees through Genetic Engineering’. Genetic Engineering and Biotechnology: high value crop plants and forest trees: model and non-model species.

HONORS, AWARDS, AND CITATIONS Sigma Xi, Science and Engineering, 1983-P University of Illinois Intercollegiate Athletics Varsity Letter: ‘Pioneer in Adaptive Sports’, 2004.

TEACHING MEPS 620 Plant Cell Physiology, 3 Cr. hr., lecture MEPS/ESSM 650 Plant Cell Culture in Crop Improvement, 3 Cr. hr., lecture/lab

PUBLICATIONS (REFEREED, PUBLISHED) – LAST 2 YEARS Department of Ecosystem Science and Management Vita J. Gould

DeBona, Gould J, Miller CJ, Stelly D, Louzada. 2009. Citrus asymmetric somatic hybrids produced by fusion of gamma-irradiated + iodoacetamide-treated protoplasts. Brazilian Journal of Agricultural Research, 44:454-462. DeBona C, Gould J, Miller CJ Jr, Stelly DM, Louzada ES. 2008. Irradiated microprotoplast-protoplast fusion for future radiation map in Citrus. ARTIGO 17:117-123. DeBona C, Gould J, Miller CJ Jr, Mceachern GR, Setamou M, Louzada ES. 2008 In Vitro Propagation of Nine Grape Cultivars. Subtropical Plant Science 59 56-63. BOOKS, CHAPTER Gould J. Transformation of plant meristems, invited Chapter. In: Trigiano R. Ed : Plant Tissue Culture, Development and Biotechnology CRC Press. Submitted Jan. 2009.

POSTERS-PRESENTATIONS Gould J, Arnold M. 2009. The effects of light on development of true shoots in excised immature cotton embryos (Texas Marker-1) cultured in vitro. ASPB annual meeting, July 17-23, Honolulu, HI. Gould J, Arnold M. 2008. Evaluation of cultural conditions for immature cotton embryo development into plants using image analysis. ASPB annual meeting. June 22-26, Merida Mexico. Ren Y, Crosby K, Bang H, Gould J. 2008. Tissue culture of muskmelon (Cucumis melo L.) ASHS-2008 Annual Conference, 21 - 24 July, Orlando, FL. Bona CM, Gould J, Miller JC, Stelly DM, Louzada ES. 2008. Asymmetric hybridization: a tool to be used in Citrus radiation map creation Abst 3107 ASHS-2008 Annual Conference, 21 - 24 July, Orlando, FL. Bona CM, Gould J, Miller JC, Stelly DM, Louzada ES. 2008 In vitro regeneration of somatic symmetric and asymmetric hybrid citrus plantlets produced via protoplast fusion Abst 3106 ASHS-2008 Annual Conference, 21 - 24 July, Orlando, FL. Bona CM, Gould J, Miller JC, Stelly DM, Louzada ES. 2008. Symmetric and asymmetric somatic hybridization in Citrus spp. for scion genetic diversity generation Abst 3105 ASHS-2008 Annual Conference, 21 - 24 July, Orlando, FL. Gould JH, Finlayson S, Engelke M. 2007. Suppression of Flowering in Commercial Turfgrass and Other Species. Consortium for Plant Biotechnology Research. Washington DC. Gould JH. 2007. Modification of Seed Development in Opuntia ficus indica. Consortium for Plant Biotechnology Research. Washington DC. Arnold M, Gould J. 2007. In vitro conditions for examination of early cotyledonary to maturation stage cotton embryos. Am. Soc. Plant Biology annual meeting. Chicago IL.

INTELLECTUAL PROPERTY and TECHNOLOGY TRANSFER Smith RH, Gould JH, Ulian EC. 1992. Transformation of Plants Via the Shoot Apex, TAMUS US Patent No. 5,164,310. Patent Application filed, June 1988.

RESEARCH GRANTS AND CONTRACTS (Last 5 Years) Gould JH. 2008-2010. D’Arrigo Bros. Inc., Transformation of commercial Opuntia indica for improved fruit quality $135,000. Gould JH. 2007. D’Arrigo Bros. Inc., Transformation of commercial Opuntia indica for improved fruit quality $98,000. Gould JH. 2006. D’Arrigo Bros. Inc., Transformation of commercial Opuntia indica for improved fruit quality $195,000. Gould JH. 2005. D’Arrigo Bros. Inc., Transformation of commercial Opuntia indica for improved fruit quality $200,000 Gould JH. 2003. Principal Investigator. Cotton Inc. $35,000. Gossypol genes: transformation and regeneration Core Project No. 99-700. Gould JH. 2006-2008 PI, THECB-ARP $100,000. Regulation of Cottonseed Gossypol (Proposal). Gould JH. 2002-04. Principal Investigator. THECB-ATP $215,284. Antisense Approach to Reduce Gossypol in Cottonseed.

2 Principal Investigator/Program Director (Last, First, Middle):

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Melissa A. Grunlan Assistant Professor eRA COMMONS USER NAME mgrunlan EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) North Dakota State University B.S. 1991-1995 Chemistry North Dakota State University M.S. 1995-1997 Polymers & Coatings University of Southern California Ph.D. 2001-2004 Chemistry Texas A&M University Post-doc 2004-2005 Chemistry

A. Positions and Honors. Positions and Employment 1997-2001 Senior Chemist, The H.B. Fuller Company (St. Paul, MN) 2004-2005 Post-doctoral research associate, Dept. of Chemistry, Texas A&M University (College Station, TX) 2005- Assist. Professor, Dept. of Biomedical Engineering, Texas A&M University (College Station, TX)

Other Experience and Professional Memberships 1997- American Chemical Society (ACS) 2007- Materials Research Society (MRS) 2007- Biomedical Engineering Society (BMES)

Honors & Awards 2001 Quarterly Technical Achievement Award, The H.B. Fuller Company 2005 Doctoral Dissertation Award, University of Southern California

B. Selected peer-reviewed publications (in chronological order). 1. Grunlan, J.C.; Ma, Y.; Grunlan, M.A.; Francis, L.F. ”Monodisperse latex with variable glass transition temperature and particle size for use as matrix starting material for conductive polymer composites,” Polymer 2001, 42, 6913-6921. 2. Grunlan, M.A., Mabry, J.M.; Weber, W.P. “Synthesis of fluorinated copoly(carbosiloxane)s by Pt-catalyzed hydrosilylation copolymerization,” Polymer 2003, 44, 981-987. 3. Grunlan, M.A.; Lee, N.S.; Weber, W.P. “Synthesis of 1,9-bis[glycidyloxypropyl]penta(1’H,1’H,2’H,2’H- perfluoroalkylmethylsiloxane)s and copolymerization with piperazine,” Polymer 2004, 45, 2517-2523. 4. Grunlan, M.A.; Lee, N.S.; Weber, W.P. “Crosslinking of 1,9-bis[glycidyloxypropyl]penta(1’H,1’H,2’H,2’H- perfluoroalkylmethylsiloxane)s with α,ω-diaminoalkanes: the cure behavior and film properties,” J. Appl. Polym. Sci. 2004, 94, 203-210. 5. Grunlan, M.A.; Lee, N.S.; Cai, G.; Gädda, T.; Mabry, J.M.; Mansfeld, F.; Kus, E.; Wendt, D.E.; Kowalke, G.L.; Finlay, J.A.; Callow, J.A.; Callow, M.E.; Weber, W.P. “Synthesis of α,ω-bis epoxy oligo (1’H,1’H,2’H,2’H-perfluoroalkyl siloxane)s and properties of their photo-acid cross-linked films,” Chem. Mater. 2004, 16, 2433-2441. 6. Kus, E.; Grunlan, M.A.; Weber, W.P.; Mansfeld, F. “Evaluation of nontoxic polymer coatings with potential biofoul release properties using EIS,” J. Electrochem. Soc. 2005, 152, B236-B243. 7. Grunlan, M.A.; Lee, N.S.; Mansfeld, F.; Kus, E.; Finlay, J.A.; Callow, J.A.; Callow, M.E.; Weber, W.P. “Minimally adhesive polymer surfaces (MAPS) prepared from star oligosiloxanes and star oligofluorosiloxanes,” J. Polym. Sci., Part A: Polym. Chem. 2006, 44, 2551-2566.

PHS 398/2590 (Rev. 09/04) Page Biographical Sketch Format Page Principal Investigator/Program Director (Last, First, Middle): 8. Grunlan, M.A.; Regan, K.R.; Bergbreiter, D.E. “Liquid/liquid separation of polysiloxane-supported catalysts,” Chem. Comm. 2006, 1715-1717. 9. Murthy, R.; Cox, C.D.; Hahn, M.S.; Grunlan, M.A. “Protein-resistant silicones: Incorporation of PEO via siloxane tethers,” Biomacromolecules, 2007, 8, 3244-3252 10. Hou, Y.; Matthews, A.R.; Smitherman, A.M.; Bulick, A.S.; Hahn, M.S.; Hou, H.; Han, A.; Grunlan, M.A. “Thermoresponsive nanocomposite hydrogels with cell-releasing behavior,” Biomaterials 2008, 29, 3175-3184. 11. Hahn, M.S.; Liao, H; Munoz-Pinto, D.; Xin, Q.; Hou, Y.; Grunlan, M.A.; “Influence of hydrogel mechanical properties and mesh size on vocal fold fibroblast extracellular matrix production,” in press, Acta Biomaterialia 2008. 12. Murthy, R.; Shell, C.E.; Grunlan, M.A. “Surface-grafting of PEO via siloxane tethers for enhanced protein resistance” Biomaterials 2009, 30, 2433-2439. 13. Pierce, L.M.; Grunlan, M.A.; Hou Y.; Baumann, S.S.; Kuehl, T.J.; Muir, T.W. “Biomechanical properties of synthetic and biologic graft materials following long-term implantation in the rabbit abdomen and vagina,” Am. J. Obstet. Gynecol. 2009, 200, 549.e1-e8. 14. Gant, R.; Hou, Y.; Grunlan, M.A., Coté, G.L. “Development of a self-cleaning sensor membrane for implantable biosensors,” J. Biomed. Mater. Res. 2009, 90A, 695-701.

C. Research Support CURRENT: Title Novel Star-PDMS/PEO Hydrogel Scaffolds with Tunable Properties for Tissue Engineered Vascular Grafts (TEVGs) Source of Support NIH (R21) Principle Investigator Melissa A. Grunlan Dual-PI Mariah S. Hahn (CHEN) (TAMU) Total Award Amount $376,298 Budget Period 07/01/08 – 06/30/10 (2 years)

Title Self-Cleaning Sensor Membranes to Improve Glucose Monitoring In Vivo Source of Support NIH (R21) Principle Investigator Melissa A. Grunlan Co-I Gerard L. Coté (BMEN) (TAMU) Total Award Amount $378,010 Budget Period 07/17/09-06/30/11 (2 years)

Title Micropatterned Thermoresponsive Nanocomposite Hydrogel Surfaces with Self-Cleaning Behavior Source of Support NSF (CBET) Principle Investigator Melissa A. Grunlan Co-PIs Arum Han (EE) and Mariah S. Hahn (CHEN) (TAMU) Total Award Amount $300,000 Budget Period 09/09/09 – 09/08/12 (3 years)

PENDING: Title CAREER: Shape Memory Polymers with Silicon-Containing Segments Source of Support NSF (DMR) Principle Investigator Melissa A. Grunlan Date Applied 07/23/09 Total Award Amount $467,868 Budget Period 01/01/10 – 12/31/15 (5 years)

PHS 398/2590 (Rev. 09/04) Page Continuation Format Page

J. Martyn Gunn

Vice Provost for Academic Services

Education: MIBiol (Biochemistry), Institute of Biology, London, UK, 1969 PhD (Biochemistry), Sheffield University, Sheffield, UK, 1972 Post-Doctoral, Fels Research Institute, Temple University, Philadelphia

Administrative Experiences: Vice Provost for Academic Services (08/2009 – date Dean of Undergraduate Programs and Associate Provost for Academic Services (12/2006 – 07/2009) Professor, Biochemistry and Biophysics, Nutrition, and Biotechnology Department of Biochemistry & Biophysics Texas A&M University

Texas A&M Faculty Senate: Speaker, 2004-2005 Member, 2002-2006 Chair, Core Curriculum Council, 2005-2006 Member, Executive Committee, 2002-2006

University Committees: Current Chair, Task Force on Enrollment Management Member, President’s Staff, 2007-date Member, Provost’s Administrative Team, 2007-date Member, Advisory Committees for each International Teaching & Research Center Member, Pandemic Flu Operations Committee Member, Academic Operations Council Member, Development Strategy Council, 2007-date Member, EIS Executive Council, 2007-date Member, EIS Steering Committee, 2007-date Member, Academic Program Review, 2007-date Member, Athletic Council, 2007-date

Recent Chair, Academic Operations Committee, 2007-2009 Chair, Academic Operations Committee Deans, 2007-2009 Chair, Orientation Oversight Committee, 2007-2009 Chair, Minority Recruitment and Retention Leadership Team, 2007-2009 Chair, Undergraduate Programs & Academic Services Directors, 2007-2009 Chair, Undergraduate Admissions Advisory Committee, 2007-2009 Chair, Minority Recruitment Strategy Group, 2007-2008 Chair, Enrollment Management Oversight Committee Subcommittee on Transfer Student Policy, 2008 Chair, Committee on Increasing Out-of-State Student Enrollment, 2009 Member, Enrollment Management Oversight Committee, 2007-2009 Member, Educational Environmental Council, 2007-2009 Member, Academic Program Council, 2007-2009 Member, Faculty Advisory Committee to the VP for Student Affairs, 2007-2009 Member, Career Center Advisory Council 2007-2009

Member, Qatar Undergraduate Academic Committee, 2008-2009 Member, Quality Enhancement Plan Council, 2008 Member, Tuition Policy Advisory Council, 2007-2008

College Committees: Chair, Undergraduate Programs Council, 2006

University Affiliation Committees: Member, Blinn College Brazos County Advisory Committee, 2007-date Member, Bryan ISD Early College High School Advisory Committee

State Committees: Member, ACT Council of Texas Education, 2007-date Member, THECB Undergraduate Education Advisory Committee, 2007-2009

National Committee: Judge for the National Siemens-Westinghouse Competition in Math, Science and Technology, 2002-date

Peer Reviewed publications:

34. J. M. Gunn & M. R. Brancheau (1992) Protein turnover, growth and proliferation in CHO cells: variation within and between mutant classes for salvage pathway enzymes. Biochem. J. 282, 49-57.

35. J. M. Gunn & G. James (1992) Protein Turnover in 3T3 cells transformed with c-H ras1. Biochem. J. 283, 427-433.

36. J. M. Gunn, R. Martinez-Zaguilan, S. Wald-Hopkins, D. Woolridge & R. J. Gillies (1994) NIH3T3 cells transfected with the Yeast H+-ATPase have altered rates of protein turnover. Arch. Biochem. Biophys. 314, 268-275.

37. J. M. Gunn (1994) Many an error by the same example. Trends in Biochem. Sci. 19, 359. [A letter pointing out the textbook errors in biotin-dependent carboxylation reactions]

38. J. C. Laurenz, J. M. Gunn, C. A. Jolly & R. S. Chapkin (1996) Alteration of glycerolipid and shingolipid- derived second messenger kinetics in ras transformed 3T3 cells. Biochim. Biophys. Acta 1299, 146-154.

39. R. E. Gossett, F. Schroeder, J. M. Gunn, & A. B. Kier (1997) Expression of fatty acyl-CoA binding proteins in colon cells: response to butyrate and transformation. Lipids 32, 577-585.

40. J. M. Gunn, Implementing the Recommended Curriculum in Biochemistry and Molecular Biology at a Large State University: The Texas A&M Experience. Biochem. Mol. Biol Ed, 31, 286-288, 2003.

41. Web-based Pre-test for Brooks-Cole Publishers to accompany Garrett & Grisham’s Biochemistry 3e, http://chemistry.brookscole.com/ggb3

42. M. Loudder and M. Gunn (2006) First year learning communities: from inspiration to reality in 3 months. In N. Simpson and J. Layne, eds, Student learning communities, faculty learning communities and faculty development, New Forums Press, Stillwater, OK.

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Mariah S. Hahn Assistant Professor eRA COMMONS USER NAME Department of Chemical Engineering MSHAHN EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) UT Austin, Austin, TX BS 1998 Chemical Engineering Stanford University, Stanford, CA MS 1999-2001 Elec Engineering MIT, Cambridge, MA PhD 2001-2004 Elec Eng & Comp Sci Rice University, Houston, TX Post-doc 2004-2005 Bioengineering

A. Positions and Honors. Positions Assistant Professor, Chemical Engineering, Texas A&M University 08/2005-present Adjunct Professor, Biomedical Engineering, Texas A&M University 08/2005-present

Professional societies American Institute of Chemical Engineers (AIChE) 2004-present Biomedical Engineering Society (BMES), Member 2006-present Society for Biomaterials 2006-present American Chemical Society 2007-present

Professional service Program Chair, Tissue Engineering (SFB) 2009 Women’s Initiative Committee, Chair (AIChE) 2008 Women’s Initiative Committee, Vice Chair (AIChE) 2007 Session chair (BMES Annual Meeting) 2006 Session chair (AIChE Annual Meeting) 2007

Honors College of Engineering Junior Faculty Award 2009 ASEE GSW Young Faculty Award 2009 ACS PROGRESS/Dreyfus Lectureship Award 2008 Invited Presentation, U MN Biomedical Engineering 2008 Invited Presentation, UT Austin, Biomedical Engineering 2008 Invited Presentation, Louisiana Tech CAMD 2006 National Science Foundation Graduate Fellowship 1999-2002 John Linvill Fellowship 2000 Jodie Isenhower Presidential Scholarship 1997 National Science Scholar 1995

B. Selected peer-reviewed publications (in chronological order). 1. R. Murthy, C.D. Cox, M.S. Hahn, M.A. Grunlan. Protein-resistant silicones: Incorporation of PEO via siloxane tethers. Biomacromolecules. 8(10):3244-52 (2007). 2. M.S. Hahn, C. Jao, W. Faquin, J. Grande-Allen. Glycosaminoglycan composition of the vocal fold lamina propria in relation to function. Annals of Otology, Rhinology, and Laryngology. 117(5): 371- 81 (2008). 3. J.J. Moon, S-H Lee, M.S. Hahn, B.A. Nsiah and J.L. West. Regulation of endothelial angiogenesis and vasculogenesis in synthetic poly(ethylene glycol) hydrogels modified with biomolecules. FASEB Journal. 21:706-15 (2007).

4. Y.Hou, A.R. Matthews, A.M. Smitherman, A.S. Bulick, M.S Hahn, H. Hou; A. Han, M.A. Grunlan. Thermoresponsive nanocomposite hydrogels with cell-releasing behavior. Biomaterials. 29(22): 3175-84 (2008). 5. J. Moon, M.S. Hahn, X. Li, J. West. Micropatterning of Poly(ethylene glycol) Diacrylate Hydrogels with Biomolecules to Regulate and Guide Endothelial Morphogenesis. Tissue Engineering. 15(3):579-85 (2009). 6. H. Liao, D. Munoz-Pinto, X. Qu, Y. Hou, M. Grunlan, M.S. Hahn. Influence of hydrogel mechanical properties and mesh size on vocal fold fibroblast extracellular matrix production. Acta Biomaterialia. 4(5): 1161-71 (2008). 7. A. Bulick, D. Munoz-Pinto, M. Mani, D. Cristancho, M. Urban, M.S. Hahn. Impact of Endothelial Cells and Mechanical Conditioning on Smooth Muscle Cell Extracellular Matrix Production and Differentiation. Tissue Engineering. 15(4):815-25 (2009). 8. D. Munoz-Pinto, X. Qu, M.S. Hahn. Lamina Propria Cellularity and Collagen Composition: An Integrated Assessment of Structure in Humans. Annals of Otology, Rhinology, and Laryngology. 118(4):299-306 (2009). 9. D. Munoz-Pinto, A. Bulick, M.S. Hahn. Uncoupled Investigation of Scaffold Modulus and Mesh Size on Smooth Muscle Cell Behavior. J Biomed Mater Res A. 90(1):303-16 (2009). 10. D. Munoz-Pinto, C.A. Jimenez-Vergara, L.M. Gelves, R. McMahon, V. Guiza-Arguerro, M.S. Hahn. Probing Vocal Fold Fibroblast Response to Hyaluronan in Controlled 3D Contexts. Biotechnology and Bioengineering. In Press.

C. Current Funding. 1. Title: Systematic tissue engineering-based evaluation of material implants for restoration of scarred vocal fold lamina propria Total Award Amount: $206,658; Source of Support: NIH/NIDCD R03 Start-End Dates: 12/01/2007-11/31/2010 2. Title: In vitro platform for the systematic investigation of scaffold properties on TEVG outcome Total Award Amount: $308,000; Source of Support: AHA National Scientist Development Award Start-End Dates: 01/01/2008-12/31/2011 3. Title: Novel PDMSstar-PEO hydrogels for vascular tissue engineering Total Award Amount: 376,298; Hahn Amount: $192,101; Source of Support: NIH/NHLBI R21 Start-End Date: 08/01/2008-07/31/2010 4. Title: Design and in-vitro characterization of Ni-free biocompatible shape memory alloys Total Award Amount: 414,234 Hahn Amount: $185,148; Source of Support: NSF-CBET Start-End Dates: 09/01/2007-08/31/09 5. Title: Materials world network: U.S.-Japan research collaboration in meta-magnetic shape memory alloys with enhanced ductility and controlled porosity Total Award Amount: $329,246; Hahn Amount: $104,457; Source of Support: NSF-DMR Start-End Dates: 08/01/2009-07/30/2011 6. Title: Collaborative research: Ligament tissue engineering Hahn Award Amount: $75,000; Source of Support: NSF-CBET Start-End Dates: 09/01/2009-08/31/2011 7. Title: Micropatterned thermoresponsive nanocomposite hydrogel surfaces with self-cleaning behavior Total Award Amount: $265,426; Hahn Amount: $50,000; Source of Support: NSF-CBET Start-End Dates: 09/01/2009-08/31/2011

TIMOTHY C. HALL

1. Personal Data

Business Address Institute of Developmental and Molecular Biology MS 3155 Texas A&M University College Station, TX 77843-3155 Phone: (979) 845-7728; Fax, (979) 862-4098 Home Address 1044 Rose Circle, College Station TX 77840-2309 Phone: (979) 696-8373; Fax (979) 693-5500 E-mail [email protected] U.S. citizen Naturalized 26 May 1978

Education University of Nottingham, 1959-65. Ph.D. (Plant Physiology) 1965; supervisor: Prof. E. C. Cocking, F.R.S. Thesis title: Protein Synthesis in Tomato Cotyledons and Leaves. B.Sc. (Class I, Honors) 1962.

Military Service Royal Air Force, 1956-1958, Pilot Officer, Sword of Honor for jet flying school; 1959-1962, Flying Officer, Volunteer Reserve, Nottingham University Air Squadron.

Employment Director, Institute of Developmental and Molecular Biology, and Distinguished Professor of Biology, Texas A&M University, 1992-present. Distinguished Professor and Head of Biology, Texas A&M University, 1984-1992. Director, Agrigenetics Advanced Research Division, Madison, 1980-1984. Director, Agrigenetics Research Corporation, Boulder, CO, 1981-1984. Adjunct Professor of Biophysics and Genetics, University of Wisconsin-Madison, 1982-1984. Professor, Horticulture, University of Wisconsin-Madison, 1975-1982; Associate Professor, 1970-1975; Assistant Professor, 1966-1970. Louis W. and Maud Hill Postdoctoral Fellow, Horticultural Science, University of Minnesota-St. Paul, 1965-1966. Ministry of Supply, England, 1959: Assistant Experimental Officer, Chemical Inspectorate.

Sabbatical Leave John Innes Institute, Norwich, England. Jul - Aug 1997. John Innes Institute, Norwich, England. Jul 1981. Université Louis Pasteur, Strasbourg, France. Jan-Jul 1977.

Scientific Societies

American Association for the Advancement of American Phytopathological Society Science American Soc. for Biochemistry and Molecular American Association of Cereal Chemists Biology American Association of University Professors American Society for Microbiology

1 American Society of Plant Physiologists Federation of American Socs. for Experimental American Society for Virology Biology Biochemical Society Indian Virological Society (Fellow). Intl. Soc. for Molecular Plant-Microbe Interactions International Society for Plant Molecular Biology RNA Society Sigma Xi Society for General Microbiology Society for In Vitro Biology (formerly Tissue Culture Association)

2. Honors and Recognitions Listed in: Marquis Who's Who in the World, 1993-; Marquis Who's Who in Science and Engineering, 1994;-Marquis Who's Who in America, 1993-; American Men and Women of Science. Jacques Cattell Press, New York and London; Marquis Who's Who in the Midwest; Who's Who in Technology Today. J. Dick and Company, Highland Park, IL. Member, editorial board of Oxford Surveys of Plant Molecular and Cell Biology, 1983-1988. Member, editorial board of The Plant Journal, 1991- 1999. Organizer, Juan March Meeting on Chromatin and DNA modification, Oct. 1998. Member, editorial board of Journal of Virology, 1996-2005. Member, NSF Committee of Visitors for Molecular Structure & Function and Biomolecular Processes Programs. Washington, July 9-13, 2000. Member, NIH Reviewers Reserve; NIH Shared Equipment Grants, 1996 Member, editorial board of Transgenic Research, 1991-1995. Lansdowne Visiting Lecturer, University of Victoria, Department of Biochemistry and Microbiology, Victoria, B.C., Canada. Oct 1994. Member of external panel for NSF-EPSCoR Biotechnology Program Review at Oklahoma Universities (U. Oklahoma, Oklahoma State, U. Tulsa) Aug 30 - Sep 2, 1994. Member of external panel for USDA-CSRS Program Review, Department of Biochemistry, North Carolina State University, Raleigh, NC, Nov 2-5, 1993. Life Fellow of the Indian Virology Society, 1992. Member of external panel for USDA-CSRS Program Review, Department of Plant Molecular Physiology, University of Hawaii at Manoa. Mar 19-21, 1990. Member N.S.F. Small Business Innovation Research Panel, 1987, 1989. Chair and organizer for the 1987 Gordon Conference on Plant Molecular Biology. Served on COSEPUP Briefing Panel on Biotechnology in Agriculture, National Research Council, Washington, D.C., Mar 1985. Co-Organizer of 4th N.A.T.O. Plant Molecular Biology Conference, Renesse, The Netherlands, 1984. Invited to Chair session on Molecular Biology at the Royal Society Conference on Seed Proteins, London, England, Jun 8-9, 1983. Chairman of Session, U.C.L.A. Symposium on Plant Molecular biology, Keystone, CO, Apr 16-22, 1983, "From Test Tube to Farm" in Plant Molecular Biology, Alan Liss, Inc., NY, pp. 481-484.

2 BIOGRAPHICAL SKETCH

NAME POSITION TITLE Han, Arum Assistant Professor DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) Seoul National University, Seoul, Korea B.S. 1997 Electrical Engineering University of Cincinnati, OH M.S. 2000 Electrical Engineering Georgia Institute of Technology, GA Ph.D. 2005 Electrical Engineering

A. Positions and Honors

Positions and Employment 2005 - present Assistant Professor, Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX 2006 - present Assistant Professor, Department of Biomedical Engineering, Texas A&M University, TX

Honors and Awards 1997-2000 University Graduate Scholarship, Department of Electrical and Computer Engineering and Computer Science, University of Cincinnati 2000 DARPA/NSF/Transducers Research Foundation Student Travel Award, Nara, Japan 2002 IEEE EMBS Student Travel Grant, Wisconsin (2002) 2003 DARPA/NSF/Transducers Research Foundation Student Travel Award, Boston, MA

B. Selected peer-reviewed publications (selected out of 32)

1. A. Han, L. Yang, and A. B. Frazier, “Quantification of the Heterogeneity in Breast Cancer Cell Lines using Whole Cell Impedance Spectroscopy,” Clinical Cancer Research, Vol. 13, 1, pp. 139-143, 2007. 2. E. D. Moss, A. Han, and A. B. Frazier, “A Fabrication Technology for Multi-Layer Polymer-Based Microsystems with Integrated Fluidic and Electrical Functionality,” Sensors and Actuators B, Vol. 121, pp. 689-697, 2007. 3. A. Han and A. B. Frazier, “Ion Channel Characterization using Single Cell Impedance Spectroscopy,” Lab Chip, Vol. 6, pp. 1412-1414, 2006. 4. K. -H. Han, A. Han, and A. B. Frazier, “Microsystems for Isolation and Electrophysiological Analysis of Breast Cancer Cells in Blood,” J. Biosensors and Bioelectronics, Vol. 21, pp. 1907-1914, 2006. 5. A. Han, L. J. Cruz-Rivera, and A. B. Frazier, “Study of Breast Cancer using Whole Cell Impedance Spectroscopy,” The 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS 2005), Boston, MA, pp. 364-366, 2005. 6. A. Han, K. -H. Han, and A. B. Frazier, “Microsystems for Whole Blood Purification and Electrophysiological Analysis,” J. Semiconductor Technology and Science, Vol. 5, No. 1, pp. 1-10, 2005. 7. A. Han, M. Graff, O. Wang, and A. B. Frazier, “An Approach to Multilayer Microfluidic Systems with Integrated Electrical, Optical, and Mechanical Functionality,” IEEE Sensors Journal, 5(1), 82-89, 2005. 8. A. Han, E. Moss, and A. B. Frazier, “Whole Cell Electrical Impedance Spectroscopy for Studying Ion Channel Activity,” The 13th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers ’05), Seoul, Korea, pp. 1704-1707, 2005. 9. A. Han, O. Wang, M. Graff, S. K. Mohanty, T. L. Edwards, K. -H. Han, and A. B. Frazier, “Multi-layer plastic/glass microfluidic systems containing electrical and mechanical functionality,” Lab on a Chip, 3(3), 150-157, 2003. 10. A. Han, E. Moss, R. D. Rabbitt, K. L. Engisch, and A. B. Frazier, “A Single Cell Multi-Analysis System for Electrophysiological Studies,” The 12th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers ’03), Boston, MA, pp. 674-677, 2003. 11. A. Han, M. Graff, O. Wang, S. K. Mohanty, K. -H. Han, and A. B. Frazier, “A Multi-Layer Plastic / Glass Technology for Microfluidic Systems with Integrated Functionality,” The 12th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers ’03), Boston, MA, pp. 1315-1318, 2003. 12. K. W. Oh, A. Han, S. Bhansali, and C. H. Ahn, “A Low-temperature Bonding Technique using spin-on fluorocarbon polymers to assemble Microsystems,” J. Micromech. Microeng. 12(2), pp. 187-191, 2002. 13. A. Han, E. Moss, R. D. Rabbitt, and A. B. Frazier, “A Multi-purpose Micro System for Electrophysiological Analyses of Single Cells,” Micro Total Analysis Systems 2002, Nara, Japan, pp. 805-807, 2002. 14. A. Han, M. Graff, O. Wang, and A. B. Frazier, "A Multi-Layer Microfluidic System with Integrated Electrical and On-Column Optical Detection," 1st IEEE international conference on sensors (IEEE Sensors 2002), Orlando, pp. 56.2, 2002. 15. A. Han, O. Wang, S. K. Mohanty, M. Graff, and A. B. Frazier, “A Multi-Layer Plastic Packaging Technology for Miniaturized Bio Analysis Systems Containing Integrated Electrical and Mechanical Functionality,” 2nd Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine & Biology, Madison, WI, pp. 66-70, 2002. 16. J. -W. Choi, K. W. Oh, A. Han, N. Okulan, C. A. Wijayawardhana, C. Lannes, S. Bhansali, K. T. Schuleter, W. R. Heineman, H. B. Hallsall, J. H. Nevin, A. J. Helmicki, H. T. Henderson, and C. H. Ahn, "Development and Characterization of Microfluidic Devices and Systems for Magnetic Bead-Based Biochemical Detection," Journal of Biomedical Microdevices, 3(3), pp. 191-200, 2001. 17. D. E. Starkey, A. Han, J. J. Bao, C. H. Ahn, K. R. Wehmeyer, M. C. Prenger, H. B. Halsall, and W. R. Heineman, “A Fluorogenic Assay for β-glucuronidase using microchip-based capillary electrophoresis,” J. Chromatography B, 762, pp. 33-41, 2001. 18. S. K. Mohanty, M. Graff, K. Ravula, A. Han, and A. B. Frazier, “A Micro Stenciling Process for Wafer Scale Metallization of Plastic Substrates,” Proceedings of the Micro Total Analysis Systems’2001 (μ-TAS 2001) Workshop, Monteray, CA, pp. 387-388, 2001. 19. J. –W. Choi, N. Okulan, A. Han, K. W. Oh, S. Bhansali, V. Govind, K. Schlueter, J.H. Nevin, W.R. Heineman, H.B. Halsall and A.J. Helmicki, H.T. Henderson, C.H. Ahn, “Development and Characterization of A Generic Microfluidic Subsystem toward Portable Bio/Chemical Detection,“ Proceedings of the Micro Total Analysis Systems’2000 (μ-TAS 2000) Workshop, Netherland, pp. 327-330, 2000. 20. A. Han, K.W. Oh, S. Bhansali, and Chong H. Ahn, “A Low Temperature Biochemically Compatible Bonding Technique using Fluoropolymers for Biochemical Microfluidic Systems,” The Thirteenth IEEE International Micro Electro Mechanical Systems Conference (IEEE MEMS 2000), pp. 414-418, Miyazaki, Japan, 2000. 21. S. Bhansali, A. Han, M. Patel, K.W. Oh, Chong H. Ahn and H.T. Henderson, “Resolving chemical/bio- compatibility issues in microfluidic MEMS systems,” Proc. SPIE Conference on Microfluidic Devices and Systems II, Vol. 3877, pp. 101-109, Santa Clara, CA, 1999. 22. B.W. Kim, A. Han, S. W. Lee, D. Cho, H. J. Lee, K. H. Cho, “(110) Silicon corner compensation and its application in fabrication of accelerometer sensing structure,” J. KIEE, vol. 46, no. 10, pp. 1546-1556, 1997.

C. Research Support

Ongoing Research Support

1R21EB005695 Wright (PI) 8/01/06-7/31/08 NIH/NIBIB Transmit/Receive Single Echo Acquisition MRI ($403,695) Role: Co-Investigator

1R21EB07297-01 Han (PI) 6/1/2007-5/31/2009 NIH/NIBIB An Integrated Microfluidic Cryo-Cooling System for MR Microcoils ($387,373) Role: PI

1002970790 Han (PI) 6/1/2007-5/31/2008 Seoul Technopark and the Korean Ministry of Commerce and Energy Hybrid Nano/Micro/Bio Packaging for Nano/Micro Scale Bio-IT Elements ($80,000) Role: PI

Program Director/Principal Investigator (Last, First, Middle):

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Hilty, Christian Beat Assistant Professor of Chemistry eRA COMMONS USER NAME (credential, e.g., agency login) chilty EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) Swiss Federal Institute of Technology, Zürich Diploma 1995-1999 Physics Swiss Federal Institute of Technology, Zürich Dr. sc. 1999-2004 Biophysics University of California, Berkeley 2004-2006 Chemistry

A. Positions and Honors Positions and Employment 1999-2004 Research Assistant, Swiss Federal Institute of Technology (ETH) Zürich 2004-2006 Postdoctoral Researcher, University of California, Berkeley and Lawrence Berkeley National Laboratory 2006- Assistant Professor of Chemistry, Texas A&M University

Professional Memberships 2005- Member, American Chemical Society 2006- Member, American Physical Society

Honors 2005 Raymond Andrew Prize, Ampere Society 2006 Camille and Henry Dreyfus New Faculty Award 2009 CAREER Award, National Science Foundation

B. Peer-reviewed publications 1. Hilty, C. and Winterhalter, M. Facilitated substrate transport through membrane proteins. Phys. Rev. Lett. 2001;86(24):5624-5627. 2. Fernández, C., Hilty, C., Bonjour, S., Adeishvili, K., Pervushin, K. and Wüthrich, K. Solution NMR studies of the integral membrane proteins OmpX and OmpA from Escherichia coli. FEBS Lett. 2001; 504(3):173- 178. 3. Winterhalter, M., Hilty, C., Bezrukov, S.M., Nardin, C., Meier, W. and Fournier, D. Controlling membrane permeability with bacterial porins: application to encapsulated enzymes. Talanta 2001;55(5):965-971. 4. Etezady-Esfarjani, T., Hilty, C., Wüthrich, K., Rueping, M., Schreiber, J. and Seebach, D. NMR-Structural Investigations of a β3-Dodecapeptide with Proteinogenic Side Chains in Methanol and in Aqueous Solutions. Helv. Chim. Acta 2002;85(5):1197-1209. 5. Hilty, C., Fernández, C., Wider, G. and Wüthrich, K. Side chain NMR assignments in the membrane protein OmpX reconstituted in DHPC micelles. J. Biomol. NMR 2002; 23(4):289-301. 6. Fernández, C., Hilty, C., Wider, G. and Wüthrich, K. Lipid-protein interactions in DHPC micelles containing the integral membrane protein OmpX investigated by NMR spectroscopy. P. Natl. Acad. Sci. USA 2002;99(21):13533-13537. 7. Hilty, C., Wider, G., Fernández, C. and Wüthrich, K. Stereospecific assignments of the isopropyl methyl groups of the membrane protein OmpX in DHPC micelles. J. Biomol. NMR 2003;27(4):377-382.

PHS 398/2590 (Rev. 11/07) Page 1 Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle):

8. Fernández, C., Hilty, C., Wider, G., Güntert, P. and Wüthrich, K. NMR structure of the integral membrane protein OmpX. J. Mol. Biol. 2003;336(5):1211-1221. 9. Tafer, H., Hiller, S., Hilty, C., Fernández, C. and Wüthrich, K. Nonrandom Structure in the Urea-Unfolded Escherichia coli Outer Membrane Protein X (OmpX). Biochemistry 2004;43(4):860-869. 10. Hilty, C., Wider, G., Fernández, C. and Wüthrich, K. Membrane protein-lipid interactions in mixed micelles studied by NMR spectroscopy with the use of paramagnetic reagents. ChemBioChem 2004;5(4):467-473. 11. Seebach, D., Mathad, R.I., Kimmerlin, T., Mahajan, Y.R., Bindschadler, P., Rueping, M., Jaun, B., Hilty, C. and Etezady-Esfarjani, T. NMR-Solution Structures in Methanol of an α-Heptapeptide, of a β3/β2- Nonapeptide, and of an all-β3-Icosapeptide Carrying the 20 Proteinogenic Side Chains. Helv. Chim. Acta 2005;88(7):1969-1982. 12. Hilty, C., McDonnell, E., Granwehr, J., Pierce, K., Han, S.I. and Pines, A. Microfluidic gas flow profiling using hyperpolarized xenon and remote detection. P. Natl. Acad. Sci. USA 2005;102(42):14960-14963. 13. McDonnell, E., Han, S.I., Hilty, C., Pierce, K.L. and Pines, A. NMR analysis on microfluidic devices by remote detection. Anal. Chem. 2005;77:8109-8114. 14. Lee, D., Hilty, C., Wider, G. and Wüthrich, K. Efficient Correlation Time Measurements for Macromolecules from NMR Relaxation Interference. J. Magn. Reson. 2006;178:72-76. 15. Hilty, C., Lowery, T.J., Wemmer, D.E. and Pines, A. Spectrally Resolved Magnetic Resonance Imaging of the Xenon Biosensor. Angew. Chem. Int. Edit. 2006;45(1):70-73. 16. Baker, K.A., Hilty, C., Peti, W., Prince, A., Pfaffinger, P.J., Wider, G., Wüthrich, K. and Choe, S. N-terminal inactivation of a voltage-gated K channel viewed by NMR in solution. Biochemistry 2006;45(6):1663-1672. 17. Schröder, L., Lowery, T.J., Hilty, C., Wemmer, D.E. and Pines, A. Targeted Molecular Imaging using Magnetic Resonance of Hyperpolarized Noble Gas. Science 2007;314:446-449. 18. Harel, E., Hilty, C., Koen, K., McDonnell, E.E. and Pines, A. Time-of-Flight Flow Imaging of Two-Phase Flow inside a Microfluidic Chip. Phys. Rev. Lett. 2007;98:017601. 19. Anwar, M.S., Hilty, C., Chu, C., Bouchard, L.S., Pierce, K.L. and Pines, A. Spin coherence transfer in chemical transformations monitored by remote detection NMR. Anal. Chem. 2007;79(7):2806-2811. 20. Koptyug, I.V., Kovtunov, K.V., Burt, S.R., Anwar, M.S., Hilty, C., Han, S.I., Pines, A. and Sagdeev, R.Z. para-Hydrogen-Induced Polarization in Heterogeneous Hydrogenation Reactions. J. Am. Chem. Soc. 2007;129(17):5580-5586. 21. Granwehr, J., Harel, E., Hilty, C., Garcia, S., Chavez, L., Pines, A., Sen, P.N., Song, Y.Q. Dispersion measurements using time-of-flight remote detection MRI. Magn. Reson. Imaging 2007;25(4):449-452. 22. Tellki, V.-V., Hilty, C., Garcia, S., Harel, E., Pines, A. Quantifying the Diffusion of a Fluid through Membranes by Double Phase Encoded Remote Detection Magnetic Resonance Imaging. J. Phys. Chem. B 2007;111(50):13929-13936. 23. Verpillat, F., Ledbetter, M.P., Xu, S., Michalak, D.J., Hilty, C., Bouchard, L.-S., Antonijevic, S., Budker, D., Pines, A. Remote detection of nuclear magnetic resonance with an anisotropic magnetoresistive sensor. P. Natl. Acad. Sci. USA 2008;105(7):2271-2273. 24. Bowen, S. and Hilty, C. Time-resolved dynamic nuclear polarization enhanced NMR Spectroscopy. Angew. Chem. Int. Ed. 2008; 47(28): 5235-5237. 25. Bowen, S., Zeng, H. and Hilty, C. Chemical shift correlations from hyperpolarized NMR by off-resonance decoupling. Anal. Chem. 2008; 80(15): 5794–5798. 26. Lee, D., Walter, K.F.A., Brückner, A.-K., Hilty, C., Becker, S., Griesinger, C. Bilayer in small bicelles revealed by lipid-protein interactions using NMR spectroscopy. J. Am. Chem. Soc. 2008; 130(42): 13822– 13823. 27. Bowen, S. and Hilty, C. Temporal chemical shift correlations in reactions studied by hyperpolarized NMR. Anal. Chem. 2009; 81 (11): 4543–4547. 28. Zeng, H., Bowen, S. and Hilty, C. Sequentially acquired two-dimensional NMR spectra from hyperpolarized sample. J. Magn. Reson. 2009; 199(2): 159–165.

PHS 398/2590 (Rev. 11/07) Page 2 Continuation Format Page Program Director/Principal Investigator (Last, First, Middle):Ing, Nancy Hughes

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Nancy Hughes Ing Associate Professor eRA COMMONS USER NAME (credential, e.g., agency login) NANCYING EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) University of Florida, Gainesville, FL B.S. 1979 Zoology (Chemistry) University of Florida, Gainesville, FL D.V.M. 1984 Veterinary Medicine University of Florida, Gainesville, FL Ph.D. 1988 Molecular Biology Baylor College of Medicine, Houston, TX Post-Doc 1992 Cell Biology

Please refer to the application instructions in order to complete sections A, B, and C of the Biographical Sketch.

A. Positions and Honors. Positions and Employment 1986-1988 Research Assistant Department of Animal Science University of Missouri 1988-1992 Post-Doctoral Fellow Department of Cell Biology Baylor College of Medicine 1992- Assistant Professor Department of Animal Science Texas A&M University 1992- Joint Appointment Department of Veterinary Anatomy and Public Health (renamed Veterinary Integrative Biosciences) Texas A&M University 1998- Associate Professor Department of Animal Science Texas A&M University

Other Experience and Professional Memberships 1986 Member, Publication and Membership Committees Society for the Study of Reproduction 1993 - Member, Exec. Comm., Faculty of Genetics Texas A&M University 1996- Member Endocrine Society 1999 - Member, Exec. Comm., Faculty of Reproductive Biology Texas A&M University 1997 - 2001 Editorial Board Biology of Reproduction 1998 - 2002 Editorial Board Domestic Animal Endocrinology 2000 - Member, Exec. Comm., Faculty of Biotechnology Texas A&M University 2002 - Member Women in Endocrinology 2007- Member Texas Faculty Association 2009 - Member Am. Society for Reproductive Medicine

Honors 1979 Rita McTigue O'Connell Award Gainesville Women's Club 1979 Phi Beta Kappa 1980 ERF Award American Medical Association 1980 Graduate Fellowship for Women Entering Non-Traditional Careers University of Florida 1995 American Registry of Professional Animal Scientists 2000 Gamma Sigma Delta (Agricultural Honor Society) Texas A&M University 2005 Phi Zeta (Veterinary Medicine Honor Society) Texas A&M University

PHS 398/2590 (Rev. 11/07) Page 1 Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle):Ing, Nancy Hughes

B. Peer-reviewed publications Most relevant to the proposal 1. Robertson, J.A., Y. Zhang, L.S. Lindahl and N. H. Ing (2002) Estradiol up-regulates estrogen receptor messenger ribonucleic acid in endometrial carcinoma (Ishikawa) cells by stabilizing the message. J. Mol. Endocrinol. 29:125-35 http://jme.endocrinology-journals.org/cgi/reprint/29/1/125 2. Farnell, Y.Z. and N. H. Ing (2003) Myometrial effects of selective estrogen receptor modulators on estrogen-responsive gene expression. J. Steroid Biochem. Mol. Biol. 84: 527-536. doi:10.1016/S0960- 0760(03)00075-X 3. Farnell, Y.Z. and N. H. Ing (2003) The effects of estradiol and selective estrogen receptor modulators on gene expression and messenger RNA stability in immortalized sheep endometrial stromal cells and human endometrial adenocarcinoma cells. J. Steroid Biochem. Mol. Biol. 84: 453-61. doi:10.1016/S0960-0760(03)00066-9 4. Mitchell, D. C. and N. H. Ing (2003) Estradiol stabilizes estrogen receptor mRNA in sheep endometrium via discrete sequence elements in its 3’ untranslated region. Mol. Endocrinol. 17: 562-574. http://mend.endojournals.org/cgi/reprint/17/4/562 5. Ing, N. H., A. Laughlin, D. D. Varner, T. H. Welsh Jr., D. W. Forrest, T. L. Blanchard and L. Johnson (2004) Gene expression in the spermatogenically inactive “dark” and the maturing “light” testis tissue of the prepubertal colt. J. Androl. 25:535-44. http://www.andrologyjournal.org/cgi/reprint/25/4/535 6. Jaeger, J.A., A.K. Speigel, N.H. Ing, G.A. Johnson, F.W. Bazer, R.C. Burghardt (2005) Functional effects of transforming growth factor β on adhesive properties of porcine trophectoderm. Endocrinology 146:3933-42. http://endo.endojournals.org/cgi/reprint/146/9/3933 7. Ing, N. H., D.A. Massuto, L.A. Jaeger (2008) Estradiol regulates A+U-rich RNA-binding factor 1 p45 binding to stabilizing regions within the 3' untranslated regions of estrogen receptor-α mRNA. J. Biol. Chem. 283:1764-72. http://www.jbc.org/cgi/reprint/283/3/1764 8. Ing, N. H. (2009). Post-transcriptional effects of estrogens on gene expression: messenger RNA stability and translation regulated by microRNAs and other factors. (Review) Int. J. Med. Biol. Frontiers (in press)

Other significant publications 9. Ing, N. H., & R. M. Roberts (1989) The major progesterone-modulated proteins of the sheep uterus are serpins. J. Biol. Chem. 264:3372-3379. (Ph.D. mentor underlined) 10. Ing, N. H., J. M. Beekman, S. Y. Tsai, M.-J. Tsai, and B. W. O'Malley. (1992) Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II). J. Biol. Chem. 267:17617-17623. (Post-doc mentor underlined)

C. Research Support. Ongoing Research Support American Quarter Horse Foundation Ing (PI) 2008-2010 "Harmful Effects of Glucocorticoids on Stallion Reproduction: Gene Expression Studies Leading to a New Clincial Assay for Fertility Prediction" The goal of this project is to identify a set of genes with altered expression in the testis in response to dexamethasone treatment and use them to test stallions for stress and glucocorticoid-induced subfertility. Role: PI USDA National Research Initiatives Competitive Grant Jaeger (PI) 2005 -2009 “Integrated Function of TGFβ, Matrix Proteins, and Integrins in Porcine Implantation” The goal of this project is to determine the role of TGFb activity and integrins during the initial phase of embryo implantation in the pig. Role: Collaborator

PHS 398/2590 (Rev. 11/07) Page 2 Continuation Format Page

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person DO NOT EXCEED FOUR PAGES NAME POSITION TITLE ARUL JAYARAMAN Assistant Professor eRA COMMONS USER NAME 1JAYARAMAN EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as DEGREE INSTITUTION AND LOCATION (if YEAR(s) FIELD OF STUDY applicable) Birla Institute of Technology & Science, India B.E 1992 Chemical Engineering Birla Institute of Technology & Science, India M.Sc 1992 Physics Tufts University M.S 1994 Biochemical Engineering University of California, Irvine Ph.D 1998 Biochemical Engineering Massachusetts General Hospital Postdoc 2000 Biomedical Engineering

A. Positions and Honors. List in chronological order previous positions, concluding with your present position. List any honors. Include present membership on any Federal Government public advisory committee. Positions 1992-1993 Fermentation Engineer, Madurai Kamaraj University, India 1998-2000 Research Fellow in Surgery, Shriners Burns Hospital, Boston 2000-2003 Instructor in Surgery (Bioengineering), Harvard Medical School, Boston 2001-2003 Principal Investigator, Shriners Burns Hospital, Boston 2004- Assistant Professor, Dept. of Chemical Engineering, Texas A&M University Awards and Honors 1998 U.C. Regents Dissertation Fellowship, University of California, Irvine 1994-97 Dean’s Fellowship, University of California, Irvine Professional Memberships American Chemical Society American Institute of Chemical Engineers Biomedical Engineering Society

B. Selected peer-reviewed publications (in chronological order; out of 54)

1. Kim, J*., Hegde, M*. and Jayaraman, A. “Co-culture of bacteria and epithelial cells for investigating signal- mediated interactions in the GI tract”. Accepted Lab Chip (2009). 2. Englert, D. L., Jayaraman, A. and Manson, M. D. “Microfluidic techniques for the analysis of bacterial chemotaxis”. Methods in Molecular Biology. Vol 571 (2009). 3. Englert, D. L., Manson, M. D. and Jayaraman, A. “Using a microfluidic device to investigate interactions between signaling molecules on Escherichia coli chemotaxis”. Applied and Environmental Microbiology. 75: 4557-64 (2009). 4. Englert, D. L*., Janakiraman, V., Jayaraman, A#. and Baskaran, H#. “Modeling growth and quorum sensing in biofilms grown in microfluidic chambers”. Annals of Biomedical Engineering. 37: 1206-16 (2009). #: Joint corresponding authors 5. Huang, J. H., Kim, J., Agrawal, N., Sudarsan, A., Maxim, J., Jayaraman, A#. and Ugaz, V#. “Rapid fabrication of branched 3-D microvascular networks using electric discharge”. Advanced Materials 21: 1-5 (2009). #Joint corresponding authors. 6. Hegde, M., Wood, T. K. and Jayaraman, A. “The neuroendocrine hormone norepinephrine increases Pseudomonas aeruginosa PA14 virulence through the las quorum sensing pathway”. Applied Microbiology and Biotechnology. 84: 763-6 (2009).

7. Newton, B., Russell, W. K., Russell, D. H., Ramaiah, S. K. and Jayaraman, A. “Liver proteome analysis in a rodent model of alcoholic steatosis”. Journal of Proteome Research. 8: 1663-71 (2009). 8. Wang, S., Chen, P. C., Berthiaume, F., Toner, M., Jayaraman, A. and Yarmush, M. L. “Dynamic effect of heat shock pre-treatment on apoptotic responses to TNF-α in liver cells”. Journal of Biomechanical Engineering. In press (2009). 9. Huang, Z., Senocak, F., Jayaraman, A. and Hahn, J. “Integrated modeling and experimental approach for determining transcription factor profiles from fluorescent reporter data”. BMC Systems Biology. 2: 64 (2008) 10. Lai, N., Jayaraman, A. Lee, K. “Vascular endothelial cell growth factor receptor-2 mediates synergistic proliferation and differentiation of adipocytes and endothelial cells in co-culture”. Tissue Engineering. Epub ahead of print. (2008). 11. Jayaraman, A. and Wood, T. K. “Bacterial quorum sensing: Signals, circuits, and implications for biofilms and disease”. Annual Reviews of Biomedical Engineering. 10: 145-167 (2008). 12. Banerjee, A., Russell, W. K., Jayaraman, A. and Ramaiah, S. K. “Identification of proteins to predict the molecular basis for observed gender susceptibility in a rat model of alcoholic steatohepatitis by 2-D gel proteomics”. Proteomics. 8: 4327-37 (2008). 13. Lee, J., Zhang, XS., Hegde, M., Bentley, W. E., Jayaraman, A. and Wood, T. K. “Indole cell signaling occurs primarily at low temperatures in Escherichia coli”. ISME Journal. 2: 1007-23 (2008). 14. Bansal, T., Jesudhasan, P., Pillai, S, Wood, T. K. and Jayaraman, A. “Temporal regulation of enterohemorrhagic Escherichia coli virulence mediated by autoinducer-2”. Applied Microbiology & Biotechnology. 78: 811-9 (2008). 15. Soni, K., Jesudhasan, P., Cepeda, M., Williams, B., Hume, M., Russell, W. K., Jayaraman, A. and Pillai, S. D. “Autoinducer-2 is involved in regulating a variety of cellular processes in Salmonella typhimurium.” Foodborne Pathogens and Disease. 5: 147-53 (2008). 16. King, K. R., Wang, S., Jayaraman, A., Yarmush, M. L. and Toner, M. “Microfluidic flow-encoded switching for parallel control of dynamic cellular microenvironments”. Lab Chip 8: 107-16 (2008). 17. Bansal, T., Englert, D., Lee, J., Hegde, M., Wood, T. K. and Jayaraman, A. “Differential effects of epinephrine, norepinephrine, and indole on Escherichia coli O157:H7 chemotaxis, colonization, and gene expression”. Infection & Immunity. 75: 4597-607 (2007). 18. Senocak, F., Si, Y., Lee, K. and Jayaraman, A. “Effect of forced uncoupling protein-1 expression on 3T3-L1 adipocyte gene expression”. FEBS Letters 581: 5865-71 (2007). 19. Lee, J., Bansal, T., Jayaraman, A., Bentley, W. E. and Wood, T. K. “Enterhemorrhagic Escherichia coli biofilms are inhibited by 7-hydroxyindole and stimulated by isatin”. Applied and Environmental Microbiology 73: 4100-9 (2007). 20. Lee, J., Jayaraman, A. and Wood, T. K. “Indole is an inter-species signal mediated by SdiA”. BMC Microbiology 7: 42 (2007). 21. Soni, K., Jesudhasan, P., Cepeda, M., Williams, B., Hume, M., Russell, W. K., Jayaraman, A. and Pillai, S. D. “Proteomic analysis to identify the role of LuxS/AI-2 mediated protein expression in Escherichia coli O157:H7”. Foodborne Pathogens and Disease. 4: 463-71 (2007). 22. Singh, A., Jayaraman, A. and Hahn, J. “A case study of representing signal transduction in liver cells as a feedback control problem”. Chemical Engineering Education. 41: 177-182 (2007). 23. Y. Chu, A. Singh, A. Jayaraman, and J. Hahn, 2007. Parameter Sensitivity Analysis of IL-6 Signaling Pathways IEEE Trans Sys Biol. 1: 342-52 (2007). 24. Si, Y., Palani, S., Jayaraman, A. and Lee, K. “Effects of forced uncoupling protein 1 expression in 3T3-L1 cells on mitochondrial function and lipid metabolism”. Journal of Lipid Research 48: 826-36 (2007). 25. King, K. R., Wang, S., Jayaraman, A., Toner, M. and Yarmush, M. L. “A High-throughput Microfluidic Real-time Gene Expression Living Cell Array”. Lab-on-Chip 7: 77-85 (2007). 26. Banta, S., Vemula, M., Yokoyoma, T., Jayaraman, A., Berthiaume, F. and Yarmush, M. L. “Contribution of gene expression to metabolic fluxes in hypermetabolic livers induced through burn injury and polymicrobial sepsis in rats”. Biotechnology & Bioengineering 97: 118-37. (2007). 27. Singh, A, *Jayaraman, A., and Hahn, J. “Modeling regulatory mechanisms in IL-6 signal transduction in hepatocytes”. Biotechnology & Bioengineering. 95: 850-62 (2006). 28. Wieder, K. J., King, K. R., Thompson, D. M., Toner, M., Yarmush, M. L. and Jayaraman, A. “Optimization of reporter cells for expression profiling in a microfluidic device”. Biomedical Microdevices. 7: 213-22 (2005). 29. Jayaraman, A., Roberts, K. A., Yoon, J., Yarmush, D. M., Duan, X., Lee, K. and Yarmush, M. L. ”Identification of neutrophil gelatinase-associated lipocalin (NGAL) as a discriminant marker of the hepatocyte secreted protein response to IL-1β: a proteomic analysis,” Biotechnology Bioengineering. 91: 502-15 (2005). 30. Duan, X, Yarmush, D. M, Berthiaume, F, Jayaraman, A., and Yarmush, M. L. “Evaluation of immunoprecipitation- based depletion of albumin for two-dimensional gel separation of normal and inflamed mouse plasma”. Proteomics. 5: 3391-4000 (2005).

Bibliographical Sketch. J. Spencer Johnston

Professional Preparation Undergraduate Institutions Major Degree & Year University of Washington, Seattle, WA Zoology BS-1967 Graduate Institutions Major Degree & Year University of Arizona, Tucson, AZ Genetics Ph.D. 1972 (Advisor: W. B. Heed) Graduate Institutions Area Inclusive Date University of Texas, Austin, TX NIH postdoc - Drosophila genetics 1972-1975

Appointments Sept. ‘97 – Present: Professor, Dept. Entomol., Texas A&M University, College Station, TX 1989 – Present: Dtr. Flow Cytometry, Center for Biosystematics and Biodiversity, TAMU Sept. ‘86 – Aug. ’97: Assoc. Prof., Dept. Entomology, Texas A&M University, Col. Sta., TX Jan. ‘80 - Aug. ’86: Assoc. Prof., Dept. Entomology, Texas A&M University, Col. Sta., TX Sept. ‘75 - Dec. ’79: Asst. Prof., Dept. Biology, Baylor University, Waco, TX June ‘67 – July ’68: Systems Analyst, Boeing Company, Seattle, WA.

HONORS AND AWARDS • 1968-72 NDEA Fellow, University Of Arizona • 1972-75 NIH Fellow • 1992 Outstanding Undergraduate Genetics Professor • 1996 Outstanding Undergraduate Genetics Professor • 1998 C-value (plant Genome size) Workshop, Jodrell Labs, RBGKew, UK • 1999 Visiting Fellow, Department of Zoology, Oxford University • 2000 Comparative Insect Genomics Workshop, Washington, D.C. • 2002 NCBI Honey bee genomics workshop, Bethesda, MA • 2003 Honey bee genomics workshop, Int. Cong. Genet., Melbourne, Australia • 2003 C-value (plant Genome size) Workshop, Jodrell Labs, RBGKew, UK • 2003 Visiting Senior Fellow, St. Hugh's College, Oxford University • 2004 Invited speaker, Social insects session. Strepsipteran workshop. • 2004 Paper in Journal of Insect Molecular Biology (JIMB) chosen for the cover for the year 2005. • 2005 Paper in Ann. Botany listed in Science Citation Index as most cited in its field. • 2005 Two papers in Ann. Botany among 50 most cited in the journal history. • 2006 Author of the year: Jn. Insect Molecular Biology - (865 citations). • 2006 Four papers in Ann. Botany among 10 most cited in the journal history. • 2008 Invited speaker. Plant & Animal Genomics XVI, San Diego. • 2008 Invited speaker. International Cogress of Entomology, South Africa.

Publications – a selection of reviewed publication from the last 5 years Schmidt-Ott, Urs, Ab. Matteen Rafiqi, Klaus Sander, and J. Spencer Johnston. 2009. Extremely small genomes in two unrelated dipteran insects with shared early developmental traits. Dev. Genes Evol. DOI: 10.1007/s00427-009-0281-0. Barcenas, N. M., N. J. Thompson, V. Gomez-Tovar, J. A. Morales-Ramos, and J. S. Johnston. 2009. Sex Determination and Genome Size in Catolaccus grandis (Burks, 1954) (Hymenoptera: Pteromalidae). J. Hym. Res. 17: 201-209. Azizi, T., J. S. Johnston, S. B. Vinson. 2009. Initiation flight muscle apoptosis and wing casting in the red imported fire ant, Solenopsis invicta. Physiological Entomology 34:79-85. Gregory, T. R. and J. S. Johnston. 2008. Genome size diversity in the family Drosophilidae. Heredity 101: 228-238. Abubucker S, Martin J, Yin Y, Fulton L, Yang SP, Hallsworth-Pepin K, Johnston JS, Hawdon J, 78. McCarter JP, Wilson RK, Mitreva M. 2008. The canine hookworm genome: analysis and classification of Ancylostoma caninum survey sequences. Mol Biochem Parasitol. 157:187-92. Tsutsui, N. D., A. V. Suarez, J. C. Spagna, and J. S. Johnston. 2008. The evolution of genome size in ants. BMC Evolutionary Biology 8:64 Bennett, M. D., H. J. Price, and J. S. Johnston. 2007. Anthocyanin inhibits propidium iodide DNA fluorescence in Euphorbia pulcherrima: implications for genome size variation and flow cytometry. Ann. Botany 101:777-790. Nene, V., J. R. et al. 2007. Genome sequence of Aedes aegypti, a major arbovirus vector. Science 316 : 1718-1723. Kathirithamby, J., J. J. Gillespie, E. Jimenez-Guri, A. I. Cognato and J. S. Johnston. 2007. High nucleotide divergence in a dimorphic parasite with disparate hosts. Zootaxa 1636: 59-68. Johnston, J. S., K. S.Yoon, J. P. Strychatz, B. R. Pittendrigh, and J. M. Clark. 2007. Body lice and head lice, (Anopleura: Pediculidae) have the smallest genomes of any hemimetabolous insect reported to date. Journal of Medical Entomology 44: 1109-1112. Geraci, N. S., J. S. Johnston, J. P. Robinson, S. K. Wikel and C. A. Hill. 2007. Variation in genome size of argasid and ixodid ticks. Insect Biochem. Mol. Biol. 37: 399-408. Pinto, M. A., W. S. Sheppard, J. S. Johnston, W. L. Rubink, R. N. Coulson, N. M. Schiff, I. Kandemir and J. C. Patton. 2007. Honey bees (Hymenoptera: Apidae) of African Origin Exist in Non-Africanized Areas of the Southern United States: Evidence From Mitochondrial DNA. Ann. Entomol. Soc. Am. 100: 289–295. Azizi, T., J. S. Johnston and S. B. Vinson. 2006. A gene involved in post-mating flight muscle degeneration in red imported fire ant queens. Ann. Entomol. 100: 270-274. C. W. Whitfield, C. W., S. K. Behura, S. H. Berlocher, A. G. Clark, J. S. Johnston, W. S. Sheppard, D. R. Smith, A. V. Suarez, D. Weaver, and N. D. Tsutsu. 2006. Thrice out of Africa: Ancient and recent expansions of the honey bee, Apis mellifera. Science 314: 642-645. The Honey Bee Genome Sequencing Consortium. 2006. Insights into social insects from the genome of the honeybee Apis mellifera. Nature 443: 931-949. Gillespie, J., J. S. Johnston, J. J. Cannone, R. R. Gutell. 2006. Characteristics of the nuclear (18S, 5.8S, 28S and 5S) and mitochondrial (12S and 16S) rRNA genes of Apis mellifera (Insecta: Hymenoptera): structure, organization, and retrotransposable elements. Insect Molecular Biology 15: 657–686. Pittendrigh, B. R., J. M. Clark, J. S. Johnston. S. H. Lee, J. Romero-Severson, and G. A. Dasch. 2006. Sequencing of a New Target Genome: The Pediculus humanus humanus (Phthiraptera: Pediculidae) Genome Project. Journal of Medical Entomology 43: 1103- 1011. Coulson, R. N., M. A. Pinto, M. D. Tchakerian, K. D. Baum, W. L. Rubink and J. S. Johnston. 2005. Feral honey bees in pine forest landscapes of east Texas. Forest Ecology and Management 215:91-102. Pinto, M. A., W. L. Rubink, J. C. Patton, R. N. Coulson, J. S. Johnston. 2005. Africanization in the United States: Replacement of Feral European Honey Bees (Apis mellifera L.) by an African Hybrid Swarm. Genetics 170: 1653-1665. Gillespie, J. J., C. H. McKenna, M. J. Yoder, R. R. Gutell, J. S. Johnston, J. Kathirithamby, and A. Cognato. 2005. Assessing the odd secondary structural properties of nuclear small subunit ribosomal RNA sequences (18S) of the twisted-wing parasites (Insecta: Strepsiptera) Jn. Insect Mol. Biol. 14:625-643. Johnston , J. S., L. D. Ross, D. P. Hughes, L. Beani. and J. Kathirithamby. 2004. Tiny genomes and Endoreduplication in Strepsiptera. Insect Molecular Biology 13: 581-5. BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Kao, Katy Chia-Ling Assistant professor eRA COMMONS USER NAME KAO.KATY EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) University of California, Irvine B.S. 1997 Chemical Engineering University of California, Los Angeles Ph.D. 2005 Chemical Engineering Stanford University 2005-2007 Genetics

Please refer to the application instructions in order to complete sections A, B, and C of the Biographical Sketch.

A. Positions and Honors.

Positions

8/1997-8/1999 - Chemical Analysis Engineer. Western Digital Corporation, Lake Forest, CA. 8/2008-present - Assistant Professor. Department of Chemical Engineering, Texas A&M University.

Awards and Honors

9/2000-9/2003 - Integrative Graduate Education and Research Traineeship funded by NSF, Grant DGE9987641 4/2007-7/2008 - National Institutes of Health National Research Service Award, Grant F32 GM079113

B. Peer-reviewed publications (in chronological order)

1. Oh MK, Rohlin L, Kao KC, Liao JC. “Global expression profiling of acetate-grown Escherichia coli.” J Biol Chem. 2002 Apr 12;277(15):13175-83.

2. Hyduke DR, Rohlin L, Kao KC, Liao JC. “A software package for cDNA microarray data normalization and assessing confidence intervals.” OMICS. 2003 Fall;7(3):227-34.

3. Kao KC, Yang YL, Boscolo R, Sabatti C, Roychowdhury V, Liao JC. “Transcriptome-based determination of multiple transcription regulator activities in Escherichia coli by using network component analysis.” Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):641-6.

4. Tran LM, Brynildsen MP, Kao KC, Suen JK, Liao JC. “gNCA: A framework for determining transcription factor activity based on transcriptome: identifiability and numerical implementation.” Metabolic Engineering. 2005 Mar;7(2):128-41.

5. Kao, KC; Tran, L.M.; Liao, J.C. “A global regulatory role of gluconeogenic genes in Escherichia coli revealed by transcriptome network analysis.” J. Biol. Chem. 2005 Oct: 280(43): 36079-36087.

6. Kao, KC, Sherlock, G. “Molecular Characterization of Clonal Interference during Adaptive Evolution in Asexual Populations of Saccharomyces cerevisiae.” Nature Genetics. 2008 Dec; 40(12): 1499-504.

BIOGRAPHICAL SKETCH WENSHE LIU

A. Professional Preparation Institution Degree Year (s) Field of Study Beijing University, China B.S. 2000 Chemistry University of California, Davis, CA Ph.D. 2005 Biological Chemistry The Scripps Research Institute, La Jolla, CA Postdoctoral 2007 Chemical Biology B. Appointments 2007- Assistant Professor of Chemistry, Texas A&M University 2005-2007 Postdoctoral Fellow, The Scripps Research Institute Research Advisor: Dr. Peter G. Schultz 2000-2005 Graduate Student Researcher, University of California-Davis Research Advisor: Dr. Michael D. Toney C. Publications Related to the proposed project 1. Huang Y., Wan W., Russell W., Wang Z., Russell D.H. and Liu W., “Genetically Encoding A Ketone-containing Nε-Acetyl-L-lysine Analog into Proteins”. In preparation 2. Huang Y., Russell W., Wan W., Russell D.H. and Liu W., “A Simple Method for Genetic Incorporation of Multiple Unnatural Amino Acids into One Protein in Escherichia coli”. Angew. Chem. Int. Ed., submitted 3. Brustad E., Bushey M.L., Lee J.W., Groff D., Liu W. & Schultz P.G.* “A Genetically Encoded Boronate Containing Amino Acid” Angew. Chem. Int. Ed. Engl., 47(43):8220-8223, 2008 4. Tippmann, E.M.+, Liu, W.+, Summerer, D., Geierstanger, B., Mack, A.V., and Schultz, P.G. “A Genetic Encoded Diazirine Photocrosslinker in Escherichia coli”, ChemBioChem, 8(18):2210-2214, 2007 (+equally contributing authors) 5. Xie, J., Liu, W., and Schultz, P.G.* “A Genetic Encoded Bidentate, Metal Ion Binding Amino Acid”, Angew. Chem. Int. Ed., 46(48):9239-9242, 2007 6. Liu C.C., Braustad E., Liu W.* and Schultz P.G.* “Crystal Structure of a Biosynthetic Sulfo-hirudin Complexed with Thrombin”, J. Am. Chem. Soc., 129(35):10648-10649, 2007 (*corresponding authors in this paper) 7. Liu, W., Alfonta, L., Mack, A.V. and Schultz, P.G.* “Structural Basis for the Recognition of p- Benzoyl-L-phenylalanyl by Evolved Aminoacyl-tRNA Synthetases”, Angew. Chem. Int. Ed., 46(32): 6073-6075, 2007 8. Liu, W., Brock, A., Chen, S., Chen, S. and Schultz P.G.* “The Genetic Incorporation of Unnatural Amino Acids into Proteins in Mammalian Cells”, Nat. Methods. 4(3):239-44, 2007 Other significant publications 9. Graziano, J.J., Liu, W., Perera R., Geierstanger, B.H., Lesley, S.A., and Schultz, P.G. “Selecting Folded Proteins from a Library of Secondary Structural Elements”, J. Am. Chem. Soc., 130(1):176- 185, 2008 10. Fogle, E.J., Liu, W., Keller, J. and Toney, M.D.* “Role of Q52 in the Decarboxylation and Transamination of Dialkylglycine Decarboxylase”, Biochemistry 44(50):16392-404, 2005 11. Liu, W., Peterson, P.E., Langston, J.A., Jin, X., Zhou, X., Fisher, A.J. and Toney, M.D.* “Kinetic and Crystallographic Analysis of Active Site Mutants of Escherichia coli γ-Aminobutyrate Aminotransferase”, Biochemistry 44(8):2982-92, 2005 12. Liu, W., Peterson, P.E., Carter, R.J., Zhou, X., Langston, J.A., Fisher, A.J. and Toney, M.D.* “Crystal Structures of Unbound and Aminooxyacetate-bound Escherichia coli γ-Aminobutyrate Aminotransferase”, Biochemistry 43(34):10896-905, 2004 13. Liu, W. and Toney, M.D.* “Kinetic and Thermodynamic Analysis of the Interaction of Cations with Dialkylglycine Decarboxylase”, Biochemistry 43(17):4998-5010, 2004 14. Liu, W., Rogers, C.J., Fisher, A.J. and Toney, M.D.* “Aminophosphonate inhibitors of dialkylglycine decarboxylase: Structural basis for slow binding inhibition”, Biochemistry 41(41):12320-28, 2002 D. Synergistic Activities The PI has developed new course Chem-689, Chemical Biology which covers most of advanced chemical tools with biological applications. This course is designed for graduate students but also open for undergraduate students. He has also taught undergraduate course Chem-228, Organic Chemistry II and designed the course from biological perspectives. During the past two years, the PI has mentored one postdoc and three undergraduate students. During the past two years, the PI has coauthored five publications and presented at one international conference, the 4th Sino-US Symposium on Organic Chemistry, and one undergraduate institution, Albany State University of Georgia. The PI has also participated in activities oriented towards K-12 students (Experiments at Chemistry Road Show, Judge for Texas Science Olympiad). E. Collaborations and Other Affiliations Collaborators and Co-authors (past 24 months) Collaborators Dr. David H. Russell (Texas A&M University): Mass spectrometry characterization of NAA-incorporated proteins. Dr. Haw Yang (Princeton University): FRET analysis of adenylate kinase Dr. Jean-Philippe Pellois (Texas A&M University): Confocal imaging of cells Co-authors: Huang Y., Wan W., Russell W., Wang Z., Russell D.H., Brustad E., Bushey M.L., Lee J.W., Groff D., Tippmann, E.M., Summerer, D., Geierstanger, B., Mack, A.V., Schultz, P.G., Xie, J., Liu C.C., Alfonta, L., Brock, A., Chen, S.B., Chen, S. Graduate Advisor and Postdoctoral Sponsor Dr. Michael D. Toney (University of California-Davis): Graduate advisor Dr. Peter G. Schultz (The Scripps Research Institute): Postdoctoral advisor Postdocs mentored Dr. Yang Wang (Novartis China), Dr. Zhiyong Wang (current) Graduate students mentored Yane-Shih (Eric) Wang (current), Ying Huang (current), Yan-Jiun Lee (current), Bo Wu (current) Undergraduate students mentored Clayton Mercer, Hiren Bhakta, John Oliver, Lindsey Dodd (current, NSF REU supported student from Henderson State University), Yin Moe (current, NSF REU supported student from Albany State University). BIOGRAPHICAL SKETCH Carol A. Loopstra

Earned degrees Institution Degree Year Major North Carolina State University Ph.D. 1992 Genetics and Forestry Oregon State University M.Sc. 1984 Forest Science Oregon State University B.S. 1979 Forest Management Positions and Employment 2001-present Associate Professor, Dept. of Ecosystem Science and Management, Texas A&M University, College Station, TX, USA 2002-2006 Associate Dept. Head for Graduate Programs, Dept. of Forest Science, Texas A&M University 1995-2001 Assistant Professor, Dept. of Forest Science, Texas A&M University 1995-present Member of the Faculty of Molecular and Plant Sciences, Texas A&M University 1995-present Member of the Faculty of Genetics, Texas A&M University 2000-present Member of the Faculty of Biotechnology, Texas A&M University 1993 - 1994 Research Officer, The University of Queensland, Brisbane, Australia 1992 - 1993 Research Fellow, Griffith University, Brisbane, Australia

Teaching - Current or past 12 months FRSC 203 Dendrology GENE/MEPS 411 Biotechnology for Crop Improvement

Graduate Students – Chair or Co-Chair (those who graduated or present students) Eun-Gyu No, PhD, MEPS 1999 Hongyan Wang, PhD, MEPS 2000 G. Jack Jagadeeswaran, PhD, Genetics 2001 Pratheesh Sathyan, MS, MEPS 2005 Suk-Hwan Yang, PhD, MEPS 2005 Sreenath Palle, PhD, MEPS (expected to graduate 12/09) Candace Seeve, PhD, MEPS (expected to graduate 8/10) Professional Service Activities – past 4 years Grant panels Genome British Columbia 2008 DOE/USDA Feedstock Genomics 2006 Genome Canada 2005 Grant reviews National Science Foundation Genome Canada Consortium for Plant Biotechnology Research Manuscript reviews GENE International Journal of Plant Science Journal of Experimental Botany Journal of Forestry New Phytologist Plant Cell Reports Planta Tree Genetics and Genomes Tree Physiology Selected peer-reviewed publications during the past 5 years Total – 16 Peer reviewed, 1 Editor reviewed, 5 Chapters in books Refereed Sathyan P, Newton RJ, and Loopstra CA (2005) Genes induced by WDS are differentially expressed in two populations of aleppo pine (Pinus halepensis). Tree Genetics and Genomes 1(4):166-173 Yang S-H and Loopstra CA (2005) Seasonal variation in gene expression for loblolly pines (Pinus taeda L.) from different geographical regions. Tree Physiology 25:1063-1073 Yang S-H, Wang H, Sathyan P, Stasolla C, and Loopstra CA (2005) Real-time RT-PCR analysis of loblolly pine (Pinus taeda L.) arabinogalatactan protein and arabinogalactan- protein-like genes. Physiologia Plantarum 124: 94-126

Yang S-H, van Zyl L, No E-G, and Loopstra CA (2004) Microarray analysis of genes preferentially expressed in differentiating xylem of loblolly pine (Pinus taeda). Plant Science 166:1185-1195 Grants received (since 2000) Agency: National Science Foundation - Plant Genome Title: Association Genetics of Natural Genetic Variation and Complex Traits in Pine Multi-Institutional. – Charles Langley PI.; Carol Loopstra, Co-PI Funding: $5,902,886 total - $797,218 to TAMU Sept. 2005 – Aug. 2009.

Agency: Texas Higher Education Coordinating Board – Advanced Technology Program Title: Drought resistant Pines for Texas Forests Carol Loopstra, PI Funding: $160,000 Jan. 2002 – Dec 2003.

Agency: National Science Foundation - Plant Genome Title: Wood formation in loblolly pine. Multi-institutional. Ronald Sederoff (NCSU) PI.; Carol Loopstra, Co-PI Funding: Total $4.45 million; $111,888 to Carol Loopstra Sept. 1999 – Sept 2002.

Agency: USDA ARS – Fund for Rural America Title: Conservation and utilization of pecan genetic resources. Larry (L.J.) Grauke, PI; Carol Loopstra, Co-PI Funding: Total unknown; $135,955 to Carol Loopstra 1998-2001.

Agency: International Arid Lands Consortium Title: Influence of water deficit on gene products in Pinus halepensis. Gabriel Schiller, Carol Loopstra, Leonid Korol and Ronald Newton, Co-PIs Funding: Total $75,000; $35,000 to Carol Loopstra May 1997 – April 2000 BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Clint Magill Professor, Dept of Plant Pathology & Microbiology eRA COMMONS USER NAME magill EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) University of Illinois, Urbana BS 1963 Agriculture Sciences Cornell University, Ithaca NY PhD 1968 Genetics University of Minnesota, St. Paul Post-Doc 1969 Genetics

A. Positions/employment 1969-75: Assistant Professor, Dept. of Plant Sciences, TAMU 1975-1989: Associate Professor, Dept. of Plant Sciences, TAMU (became Dept of Plant Pathology & Microbiology in 1985) 1989-present: Full Professor, Dept of Plant Pathology & Microbiology

Honors 1963: Andrew Dixon White Fellowship and NSF Cooperative Graduate Fellowship 1967: NSF Postdoctoral Fellowship 1986: University System Award for Excellence in Undergraduate Teaching 2008: Nominated for Presidential Teaching Award 2008: Elected Speaker, TAMU Faculty Senate

B. Reviewed Journal Publications in REVERSE chronological order (selected) Ramasamy, P, Menz, MA, Mehta, PJ, Katile, S, Gutierrez Rojas, LA, Klein, RR, Klein, PE, Prom, LK, Schlueter, JA, Rooney WL, & Magill, CW 2009. Molecular mapping of Cg1, a gene for resistance to anthracnose (Colletotrichum sublineolum) in sorghum. Euphytica 165:597-606. Perumal, R, Nimmakayala, P, Erattaimuthu, SR, No, E-G, Reddy,UK, Prom, LK, Odvody, GN, Luster, D. and Magill, CW. (2008) Simple sequence repeat markers useful for sorghum downy mildew (Peronosclerospora sorghi) and related species. BMC Genetics 9:77 http://www.biomedcentral.com/1471-2156/9/77 Liu, J., Stipanovic, R.D., Bell, A.A., Puckhaber, L.S., and Magill, C.W. (2008) Stereospecfific coupling of hemigossypol to form (+)-gossypol in moco cotton. Phytochemistry 69:3038-3042. - Perumal,, R., Krishnaramanujan, R., Menz, M.A., Katilé, S., Dahlberg, J., Magill, C.W., and Rooney, W.R. (2007) Genetic Diversity among Sorghum Races and Working Groups Based on AFLPs and SSRs. Crop Sci 47:1375-1383. Sabry, A.B., Jeffers, D.,Vasal, S.K., Frederiksen, R., and Magill, C.W. (2006) A region of maize chromosome 2 affects response to downy mildew pathogens. Theor. Appl. Genet. 113:321-330. Perumal, R. Isakeit, T., Menz, M., Katilé, S., No, E-G, Magill, C.W. (2006) Characterization and genetic distance analysis of isolates of Peronosclerospora sorghi using AFLP fingerprinting. Mycological Res. 110:471-478. He, B., Magill, C. & Starr, J. (2005) Laser capture microdissection and real-time PCR for measuring mRNA in giant cells induced by Melodogyne javanica. Journal of Nematology 37: 308-312. Benedict, C.R., Martin, G., Liu, J., Puckhaber, L. and Magill C. W. 2004. Terpenoid aldehyde formation and lysigenousgland storage sites in cotton: Variant with mature glands but suppressed levels of terpenoid aldehydes Phytochemistry 65:1351-1359. Little, C. R. and Magill, C. W. 2004. Elicitation of defense response genes in Sorghum bicolor (L.) Moench in response to infection by Fusarium thapsinum and Curvularia lunata at anthesis. Mol.& Phsiol. Plant Patholgoy 63: 271 - 279. Martin, G., Liu, J., Benedict, C., Stipanovic, R., Magill, C. 2003. Reduced levels of cadinane sesquiterpenoids in cotton plants extressing antisense (+)-d-cadinene synthase. Phytochemistry 62:31-38. Liu, J., Benedict, C, Bell, AA, Stipanovic, RD, Magill, CW, 2002. Cloning and Expression of Desoxyhemigossypol-6-O-Methyltransferase from Cotton (Gossypium barbadense) Journal of Agricultural & Food Chemistry 50: 3165-3172 Cui, Y., Bell, A. A., Puckhaber, L., Joost, O., and Magill, C. 2000. Induction of defense genes in wilt-resistant and susceptible cotton cultivars by Verticillium and Fusarium. Physiol. & Mol. Plant Pathology 56:25-31. Boora, Khazan S., Richard A. Frederiksen and Clint W. Magill (1999) A molecular marker that segregates with sorghum leaf blight resistance in one cross is maternally inherited in another. Molecular and General Genetics 261:317-322. Zhou, Y, C.W. Magill, J.M. Magill and R.J.Newton (1998) An apparent case of non-symmetrical and sustained strand-specific hemi-methylation in the Dc8 gene of carrot Genome 41:23-33. Alachanti, I., J.A. Acreman, J. Liu, C.R. Benedict, R.D. Stipanovic, A.A. Bell, Y, Cui and C.W.Magill (1998) The enzymatic cyclization of nerolidyl diphosphate by d-cadinene synthase from cotton stele tissue infected with Verticillium dahliae. Phytochemistry 47:961-967. Lee, B-M., N. C. Paek, C. W. Magill, and J.D. Smith (1997) Genetic dissection of the abscisic acid biosynthetic pathway in maize (Zea mays L.) embryos. Maydica 42:331-338. Zhou Y., J.M. Magill, R.J. Newton and C.W. Magill (1997) Use of a Single Sequencing Termination Reaction to Distinguish C and 5mC in Bisulfite-Modified DNA Biotechniques 22:850-854. Cui, Y., J.M. Magill, R.A. Frederiksen and C. W. Magill (1996) Responses of chalcone synthase and phenylalanine-ammonia lyase to fungal pathogens in sorghum. Physiological and Molecular Plant Pathology 49:187-199. Zhou, Y., J.M. Magill, C.W. Magill, and R.J. Newton. (1996) DNA methylation and Dc8-GUS transgene expression in carrot (Daucus carota L.). Plant Cell Reports 15:815-818. Joost, O., G. Binachini, A.A. Bell, C.R. Benedict and C.W.Magill (1995) Differential induction of 3-hydroxy-3- methylglutaryl CoA reductase in two cotton species following inoculation with Verticillium. MPMI 8:880-885 Ullian, E,C,. J.M. Magill, C.W. Magill, and R.H. Smith (1995) DNA methylation and expression of NPTII in transgenic petunias and progeny. TAG 92:976-981 Wu, B.C. and C.W. Magill (1995) Spontaneous mutations at fingerprint loci in clonal lineages of the rice blast fungus. Experimental Mycology 19:86-90. Xu, G. W. CW Magill, KF Schertz and GE Hart (1994) An RFLP map of Sorghum bicolor (L) Moench TAG 89:139-147. Cui, Y. X., G.W. Xu, C.W. Magill, K.F. Schertz, and G. E. Hart (1994) A low-copy-number Sorghum DNA sequence that detects hypervariable EcoRV fragments TAG 89:64-69. Bollich, C. N., C. W. Magill, A. B. Livore, H.H. Hung, M. A. Marchetti, and J. E. Scott. (1993) Registration of Texmont rice. Crop Sci. 33:354. Kim, D. H., R. D. Martyn, and C.W. Magill (1993) Mitochondrial DNA-Relatedness among Formae Speciales of Fusarium oxysporum in the Cucubitiacae. Phytopathology 83:91-97. Chang, S., C.W. Magill, J.M. Magill, F. Fong, and R.J. Newton (1992) PCR Amplification Following Restriction to Detect Site-Specific Methylation. Plant Molecular Biology Reporter 10:356-360. Yao, Chenglin, R.A. Frederiksen and C.W. Magill (1992) Length heterogeneity in ITS 2 and the methylation status of CCGG and GCGC sites in the rRNA genes of the genus Perosclerospora. Current Genetics 22: 415-420 Kim, D.H., R.D. Martyn, and C.W. Magill (1992) RFLP Groups and Physical Map of Mitochondrial DNA from Fusarium oxysporum f. sp. niveum. Phytopathology 82:346-353. Yao, Cheng-lin, C. W. Magill and R. A., Frederiksen (1991) An AT -Rich DNA Clone is Species-Specific for Identification of Peronosclerospora sorghi . Applied and Environmental Biology 57:2027-2032. Wiggers, J. R. J., C. W. Magill, J. L. Starr, and H. J. Price (1991) Evidence Against Amplification of Four Genes in Giant Cells Induced by Meloidogyne incognita. Journal of Nematology 23 421-424. Livore, A.B., C.E. Scheuring, and C.W. Magill (1989) The Rice psb-A Chloroplast Gene Has a Standard Location. Curr. Genet. 16:447-452. Smith, J.D., F. Fong, C.W. Magill, D.J. Hole, and B.J. Cobb. (1989) The Origins of Abscisic Acid Found In Developing Embryos of Zea mays L. Planta. Yao, C.L., R.A. Frederiksen, and C.W. Magill. (1989) Seed Transmission of Sorghum Downy Mildew: Detection by DNA Hybridization Seed Sci. and Technology 18:201-207. Magill, J.M. and C.W. Magill (1989) DNA Methylation in Fungi. Developmental Genetics 10:63-69. (Review)

August, 2009 CURRICULUM VITAE NAME: John Emerson Mullet Department of Biochemistry & Biophysics Texas A&M University College Station, Texas 77843 (979) 845-0722, [email protected]

EDUCATION: B.S., Biology, Colgate University, Hamilton, New York, 1972-1976. Ph.D., Cell Biology, University of Illinois, Champaign, 1976-1980.

AWARDS: Phi Beta Kappa, Summa Cum Laude Faculty Distinguished Achievement Award Christine Richardson Professor, 1991-1996 Perry Adkisson Chair in Agricultural Biology, 1996 - present

EXPERIENCE: Director, Institute for Plant Genomics and Biotechnology, 1999-2005 Director, Crop Biotechnology Center, 1993-1999 Professor, Department of Biochemistry and Biophysics, 1991- present Associate Professor, Department of Biochemistry and Biophysics, 1986 Assistant Professor, Department of Biochemistry & Biophysics, 1983 NIH Postdoctoral Fellow, Rockefeller University, 1980-1983 NATO research at the CNRS, France, 1980; Japan, 1978

PROFESSIONAL, SCIENTIFIC AND HONOR SOCIETY ACTIVITIES: NSF - Developmental Biology Panel, 1989-1992 NIH - Molecular Cytology Grant Panel, 1987, 1995, 1996 DOE - Energy Biosciences Grant Panel, 1987, 1989 USDA - CRGO Photosynthesis Panel Member, 1985, 1986 NRI Rice Genomics panel, 2003; NRI panel, 2004, 2006 ARS Quality Research Review Panel, 2000 American Society of Plant Physiologists American Society for Biochemistry and Molecular Biology Member of Texas A&M Plant Physiology, Genetics, Molecular and Cell Biology Faculty Editorial Board - Journal of Plant Physiology, 1989-1992 Co-Editor - The Plant Cell, 1996-1998 American Society of Plant Physiology Board of Trustees, 1993-1996 National Agricultural Biotechnology Committee Representative, 1995-2001 Non-Resident Fellow, Noble Foundation, 1998-2003 Noble Foundation Board Advisory Trustee, 2004-2006

CURRENT GRANT SUPPORT: Designing Sorghum for Bioenergy, Ceres Inc. Lignocellulosic Feedstocks for GenII Biofuels, Chevron Sorghum Preflowering Drought Tolerance Traits, Pioneer/DuPont Sorghum Drought Tolerance Traits, AgriLife Research

PUBLICATIONS (Total 162):

Murray, S.C., Sharma, A., Rooney, W.L., Klein, P., Mullet, J.E., Mitchell, S.E., Kresovich, S. (2008) Genetic Improvement of Sorghum as a Biofuel Feedstock: I. QTL for Stem Sugar and Grain Nonstructural Carbohydrates. Crop Science 48: 2165-2179.

Murray, S.C., Rooney, W.L., Mitchell, S.E., Sharma, A., Klein, T., Mullet, J.E., Kresovich, S. (2008) Genetic Improvement of Sorghum as a Biofuel Feedstock: II. QTL for Stem and Leaf Structural Carbohydrates. Crop Science 48: 2180-2193

Klein, R.R., Mullet, J.E., Jordan, D.R., Miller, F.R., Rooney, W.L., Menz, M.M., Franks, C.D., Klein, P.E. (2008) The Effect of Tropical Sorghum Conversion and Inbred Development on Genome Diversity as Revealed by High-Resolution Genotyping. Plant Genome 48: S12-26.

Rooney, W.L., Blumenthal, J., Bean, B., Mullet, J.E. (2007) Designing sorghum as a dedicated bioenergy feedstock. Biofuels, Bioproducts and Biorefining 1:147-157.

Yim, Y.-S., Moak, P., Shachez-Villeda, H., Musket, T.A., Close, P., Klein, P.E., Mullet, J.E., McCullen, M.D., Fang, A., Schaeffer, M.L., Gardiner, J.M., Coe, E.H., Davis, G. L. (2007) A BAC pooling strategy combined with PCR-based screenings in a large, highly repetitive genome enables integration of the maize genetic and physical maps. BMC Genomics 8:47-56.

Harris, K., Subudhi, P.K., Borrell, A., Jordan, D., Rosenow, D., Nguyen, H., Klein, P., Klein R., Mullet, J.E. (2007) Sorghum stay-green QTL individually reduce post- flowering drought-induced leaf senescence. J. Exp. Biol. 58: 327-338.

Gualtieri, R.G., Conner, J.A., Morishige, D.T., Moore, D.L., Mullet, J.E., Ozias-Akins, P. (2006) A Segment of the Apospory-Specific Genomic Region Is Highly Microsyntenic Not Only between the Apomicts Pennisetum squamulatum and Buffelgrass, But Also with a Rice Chromosome 11 Centromeric-Proximal Genomic Region. Plant Physiology 140:963-971

Kim, J.-S., Islam-Faridi, M.N., Klein, P.E., Stelly, D.M., Price, H.J., Klein, R.R., Mullet, J.E. (2005) Comprehensive Molecular Cytogenetic Analysis of Sorghum Genome Architecture; Distribution of Euchromatin, Heterochromatin, Genes and Recombination in Comparison to Rice. Genetics 171:1963-1976.

Pratt, L.H., Liang, C., Shah, M., Sun, F., Wang, H., Reid, St. P., Gingle, A.R., Paterson, A.H., Wing, R., Dean, R., Klein, R., Nguyen, H.T., Ma, H-M., Zhao, X., Morishige, D.T., Mullet, J.E., and Cordonnier-Pratt, M.-M. (2005) Sorghum Expressed Sequence Tags Identify Signature Genes for Drought, Pathogenesis, and Skotomorphogenesis from a Milestone Set of 16,801 Unique Transcripts. Plant Physiol. 139: 869-884.

Desmond Ng

Degree (s): Ph.D., 2001, University of Illinois at Urbana-Champaign, Agricultural Economics MSc, 1996, McGill University, Montréal, PQ, Canada, Agricultural Economics BSc, 1994, University of British Columbia, Vancouver, BC, Canada, Agricultural Economics (Honors)

Position: Assistant Professor in Agribusiness and Strategic Management

Department: Agricultural Economics

Primary Research Area: Dr. Ng's current research focus is concerned with strategic change and performance processes at micro, dyadic or social network and institutional levels of investigation. This emphasizes firm and inter-firm level sources of competitive advantage that employ a social network perspective in dynamic environments. This includes the development and synthesis of approaches to explain: 1) organizational change using an absorptive capacity and dynamic capabilities perspective with explicit consideration for dynamic social networks, 2) Schumpeterian entrepreneurship and innovation in supply chain networks, 3) institutional change from a complexity science perspective where the institution is a system of nested network relationships, and 4) entrepreneurship and the management of knowledge relationships in a knowledge intensive economy.

Dr. Ng received all of his degrees in Agricultural Economics. His research is focused on strategic management and agribusiness. Dr. Ng's article titled “The Paradox of Embeddedness: Strong and Weak Tie Performance in the Biotechnology Industry,” won Best Paper at the 7th International Chain Conference in June 2006. Also, he won the Outstanding Research Paper Award from the Academy of International Business and Economics in 2005 for an article titled “Strategic Change through a Competition of Realities,” and in 2004 he won Best Paper for Management, Organization Division and was nominated for the William H. Newman Award of the Academy of Management for “The Enactment of Competitive Markets and Organizational Performance.” Dr. Ng's works have been published in the Strategic Management Journal, Journal of Management Studies, Journal on Chain and Network Science, International Food and Agribusiness Management Review, Emergence, and others.

Research Interests: Strategic management and organization theory, complexity, agent-based modeling, system dynamics modeling, institutional and evolutionary theories, Austrian economics, value chain strategies, social network dynamics.

Primary Room / Phone Number: 349B Blocker Building (979) 845-1192

Fax Number: (979) 862-1563

Primary E-mail: [email protected]

Selected Publications:

Ng, D. 2008. “Understanding the Market Dynamics of Entrepreneurial Networks.” Journal on Chain and Network Science (Forthcoming)

Ng, D., Westgren, R., and Sonka, S. 2008. “Competitive Blind Spots in an Institutional Field.” Strategic Management Journal (Forthcoming)

Ng, D. 2008. “Structural Change in Food Supply Chains.” International Food and Agribusiness Management Review, 11(2):17-48.

Ng, D. 2007. “A Modern Resource Based Approach to Unrelated Diversification.” Journal of Management Studies, 44(8):1481-1502.

Ng, D., Unterschultz, J., and Laate. E. 2006. “The Performance of Relational Ties: A Functional Approach in the Biotechnology Industry.” Journal on Chain and Network Science, 6(1):9-21.

Ng, D. 2005. “Strategic Change through a Competition of Realities.” Journal of International Business Strategy, 1(1):1-10.

Ng, D. 2005. “Strategic Entrepreneurship: An Austrian Economic Approach to Competitive Strategy.” Journal of International Business Strategy, 1(1):75-84.

Hailu, G. Jeffrey, S., Goddard, E., and Ng, D. 2005. “Regulatory Environment, Co-operative Structure and Agency Costs for Co-operative Agribusiness Firms in Canada: Comparative Case Studies.” Journal of Food Distribution Research, XXXVI(2):39-49.

Ng, D. 2005. “The Discovery of and Coordination of Resource Complements in a Dispersed Knowledge Society.” International Journal of Human Resources Development and Management, 5(2): 142-163.

Zivko L. Nikolov, Ph.D.

Biological and Agricultural Engineering Texas A&M University College Station, TX 77843-2117 Pone: (979)-458-0763 Fax: 979-845-3932 E-mail: [email protected] ______

EDUCATION

Dipl. Eng. in Food Engineering, University of Novi Sad, Yugoslavia (1977) M.S. in Chemical Engineering, Iowa State University, Ames, IA (1983) Ph.D. in Chemical Engineering, Iowa State University, Ames, IA (1986)

PROFESSIONAL EXPERIENCE

Texas A&M University, College Station, TX 2003 - present Dow Professor in Bioprocess Engineering ProdiGene Inc., College Station, TX 1997-2003 Vice President, BioProcess Development and Production (3/2001 – 12/2002) Director, Processes Development (9/1999-3/2001) Iowa State University, Ames, IA 1987-1999 Professor, Biochemical and Food Engineering Kraft Foods R&D Center, Glenview, IL 1995-1996 Academic Research Fellow (on sabbatical leave from ISU) Michigan Biotechnology Institute, Lansing, MI 1986-87 Senior Scientist

RECOGNITION, SOCIETIES, AWARDS

Editorial Board Member, Brazilian Journal of Chemical Engineering 2005- Editorial Board Member, Journal of Biological Engineering 2007- Scientific Advisory Board, InB: Biotechnologies Inc. 2004 - 2007 Scientific Advisory Board, ERA Biotech, Spain, 2006- Scientific Advisory Board, DermaPlus, 2006- Advisory Board, Infinity Energy, 2007- Associate Editor, Journal of American Oil Chemists Society, 1996-1999 Academic Research Fellow, Kraft, Inc., 1995-96 Visiting Professor, School of Chemical Engineering, State University of Campinas, Brazil, 1997 Visiting Professor, Department of Chemical Engineering, Federal University of Rio Grande do Sul, Brazil, 1992. Fulbright Scholar, 1980 Member of the American Institute of Chemical Engineers, American Society of Agricultural Engineers American Chemical Society, American Oil Chemists Society, and the Institute of Biological Engineering

PROFESSIONAL ACTIVITIES Organized and chaired symposiums for American Chemical Society, American Institute of Chemical Engineers and American Oil Chemists Society. Served on NSF, NIH and USDA panels Consultant for Cargill, Fibrogen, Michigan Biotech Institute, Binney-Smith, Pioneer Hi-Bred Intl., Procter & Gamble, Rohm&Haas, DuPont Optimum Grains, Syngenta, Biolex , Ventria Bioscience, Quality Technology International.

2

SELECTED PUBLICATIONS (more than 70 publications) Kusnadi, A. R., Z. L. Nikolov, and C. Ford. 1993. Production of a functional starch-binding domain of Aspergillus glucoamylase-I in Escherichia coli. Gene 127:193. Dalmia, B. K. and Z. L. Nikolov. 1994. Characterization of a β-galactosidase fusion protein containing the starch- binding domain of Aspergillus glucoamylase. Enzyme Microb. Technol. 16:18. Cantarella, L., Z. L. Nikolov, and P. J. Reilly. 1994. Oligosaccharide production by glucoamylase in aqueous ether mixtures. Enzyme Microb. Technol. 16:383. Dalmia, B. K. and Z. L. Nikolov. 1994. A glutathione S-transferase fusion protein with the starch-binding domain of Aspergillus glucoamylase. Ann. N.Y. Acad. Sci. 721:169. Dalmia, B. K., K. Schutte, and Z. L. Nikolov. 1995. Domain E of Bacillus macerans cyclodextrin glucanotransferase: An independent starch-binding domain. Biotechnol. Bioeng. 47: 575. Evangelista, R. L. and Z. L. Nikolov. 1996. Recovery and purification of lactic acid from fermentation broth by adsorption. Appl. Biochem. Biotechnol. 57/58: 471. Kusnadi, A. R., J. Howard, and Z. L. Nikolov. 1997. Production of recombinant proteins in transgenic plants: Practical considerations. Biotechnol. Bioeng. 56: 473. Kusnadi, A. R., R. L. Evangelista, E. E. Hood, J. Howard, and Z. L. Nikolov. 1998. Production and purification of two recombinant proteins from transgenic corn. Biotechnol. Progress 14: 149-155. Kusnadi, A. R., R. L. Evangelista, E. E. Hood, J. Howard, and Z. L. Nikolov. 1998. Processing of transgenic corn and its effect on the recovery of β-glucuronidase. Biotechnol. Bioeng. 60: 44-52. Evangelista, R. L., A. R. Kusnadi, J. Howard, and Z. L. Nikolov. 1998. Process and economic evaluation of the recovery of recombinant β-glucuronidase from transgenic corn. Biotechnol. Progress. 14: 607-614. Bai, Y. and Nikolov, Z. L. 2001. Effect of processing on the recovery of recombianant β–glucuronidase from transgenic canola. Biotechnol. Progress 17:168-74. Azzoni A. R ,A.R. Kusnadi; E. A. Miranda, and Z.L. Nikolov. 2002. Recombinant aprotinin produced in transgenic corn seed: Extraction and Purification Studies, Biotechnol. Bioeng., 80: 268-276. Bai, Y., Z. N. Nikolov, and C. E. Glatz. 2002. Aqueous extraction of β-glucuronidase from transgenic canola: Kinetics and microstructure, Biotechnol. Progress, 18:1301-1305. Menkhaus, T.J., Bai , Y., Zhang, C., Nikolov, Z.L., Glatz, C.E. 2004. Considerations for the recovery of recombinant proteins from plants, Biotechnol Prog., 20:1001-1014. Nikolov, Z. L.and S. Woodard. 2004. Downstream processing of recombinant proteins from transgenic feedstock, Curr Opin Biotechnol.,15: 479-486. Lamphear, B. J., Barker, D. K. Brookes, C. A. Delaney, D. E., Lane, J.R. Beifuss, K, Love, R. Thompson, K. Mayor, J., Horn, M. E , Streatfield, S. J., Nikolov, Z., Woodard, S.L., Hood E. E., and Howard, J. A. 2005. Expression of the sweet protein brazzein in maize for production of a new commercial sweetener. Plant Biotechnol. J., 3: 103-114. Nandi, S, Yalda, E, Lu. S., Nikolov. Z. L, Misaki, R., Kazuhito, F, Huang N. 2005. Process development and economic evaluation of recombinant human lactoferrin expressed in rice grain. Transgenic Res., 14:237-249 Azzoni A. R , K. Takahashi, S.L. Woodard; E. A. Miranda, Z.L. Nikolov. 2005. Purification of recombinant aprotinin produced in transgenic corn seed: Separation from CTI utilizing ion-exchange chromatography. J. Braz. J. Chem. Eng.: 22: 323-330. Zhu, L.; van de Lavoir, M. C.; Albanese J.; Beenhouwer, D. O.; Cardarelli, P.M.; Deng, D. F.; Deshpande S.; Diamond, J. H.; Green, L; Nikolov, Z. L. et al. 2005. Production of human monoclonal antibodies in eggs of chimeric chickens. Nat. Biotechnol., 23: 1159-1169. Wilken, L. R., and Nikolov, Z. L. 2006. Factors influencing recombinant human lysozyme extraction and cation exchange adsorption. Biotechnol. Prog., 22: 745-752.

Book Chapters

Nikolov, Z. L. and P. J. Reilly. Enzymatic Depolymerization of Starch in Biocatalysts for Industry (J. S. Dordick, ed.), Plenum, New York, 1991, pp. 37-62. Meireles, M. A. and Z. L. Nikolov. Extraction and Fractionation of Essential Oils with Liquid Carbon Dioxide. In: Herbs, Spices, and Edible Fungi (G. Charalambous, ed.), Elsevier, 1994, pp. 171-199. Nikolov, Z. L. and R. Fuentes-Granados, 1999. Soybeans (Fermentation, Meal, Oil) in The Encyclopedia of Bioprocess Technology, (Flickinger, M. and Drew, S., eds.), Wiley, New York.

Principal Investigator/Program Director (Last, First, Middle):

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE William Park Professor eRA COMMONS USER NAME William Park EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) University of South Carolina, Columbia BS 1973 Chemistry University of Florida, Gainesville PhD 1977 Biochemistry

A. Positions and Honors

Positions and Employment 1973-1977 Ph.D Graduate Student at the University of Florida, Gainesville, Department of Biochemistry 1977-1979 Postdoctoral Fellow at the University of Minnesota, St. Paul, Department of Genetics and Cell Biology 1980-1983 Assistant Professor, Purdue University, Department of Horticulture 1984-1990 Associate Professor, Texas A&M University, Department of Biochemistry and Biophysics 1991 – present Professor, Biochemistry and Biophysics, Texas A&M University 1994 – present Leader, Rice Laboratory, Institute for Plant Biotechnology and Genomics, Texas A&M 2006 – present Associate Head for Graduate Programs, Dept. of Biochemistry & Biophysics

Awards and Honors 2002 The Weed Science Society of America voted our paper (Vaughan et al., 2001) as “paper of the year”. This paper showed that much of the weed red rice that is widely distributed across US commercial rice fields is closely related to Oryza rufipogon - a noxious weed previously thought to be restricted to one small area in Florida. 2007 MARS Inc. recognized our “outstanding research and significant contributions on rice knowledge”. This award was presented by the Vice President of Research and Development for MARS FOOD USA, and his counterparts from MARS FOOD Europe and MARS FOOD Australia were also in attendance. 2007 Faculty Recognition Award from the Biochemistry Graduate Association.

B. Selected peer-reviewed publications (in chronological order). Bormans, CA, RB Rhodes, DD Kephart, AM McClung, WD Park (2002) Analysis of a single nucleotide polymorphism that controls the cooking quality of rice using a non-gel based assay. Euphytica 128: 261-267. Larkin, PD, MA McClung, NM Ayres, WD Park (2003) The effect of the Wx locus (Granule Bound Starch Synthase) on pasting curve characteristics in specialty rice. Euphytica 131: 243-253. Bormans C, A McClung, A Marchetti, C Johnson, W Park (2003) Molecular markers linked to the blast resistance gene Pi-z in rice for use in marker-assisted selection. Theor. Appl. Genet. 107: 1014-1020. Larkin PD, WD Park (2003) Association of waxy gene single nucleotide polymorphisms with starch characteristics in rice (Oryza sativa L.) Molec. Breeding 12: 335-339. McClung AM, RG Fjellstrom, CJ Bergman, CA Bormans, WD Park, MA Marchetti (2003) Registration of Saber Rice. Crop Science. 44:248-249 McClung AM, CJ Bergman, RG Fjellstrom, CA Bormans, WD Park, MA Marchetti (2003) Registration of Bolivar Rice. Crop Science 44: 353-354. Fjellstrom, R, CA Conaway-Bormans, AM McClung, W Park (2004) Development of DNA Markers Suitable for Marker PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Biographical Sketch Format Page Principal Investigator/Program Director (Last, First, Middle): Assisted Selection of Three Pi- Genes Conferring Resistance to Multiple Pyricularia grisea pathotypes. Crop Science. 44: 1790-1798. Vitalini MW, RM de Paula, WD Park, D Bell-Pedersen (2006) The rhythms of life: Circadian output pathways in Neurospora. J. Biological Rhythms 21: 434-444. Dobo M, N Ayres, G Walker, WD Park (submitted) Polymorphism in the GBSS Gene Affects Amylose Content in US and European Rice Germplasm Dobo M and WD Park (manuscript in preparation) An improved RVA assay illustrates the key role of a SNP in exon 10 of granule bound starch synthase in determining the shear resistance of cooked rice. Dobo M and WD Park (manuscript in preparation) Accurate prediction of the shear viscosity of aged starch data using RVA data and simple polymer physics.

Inventions McClung, Bormans CA and WD Park (2002) Release of Hidalgo and Cala, two higher yielding long grain rice varieties having special processing quality. • Hidalgo PVP 20050051 • Cala PVP 20050052 McClung AM and WD Park (2009) Release of Deltabelle, a long grain rice with novel processing quality • PVP applied for

Technology Development and Transfer A first generation quick cooking rice product with enhanced nutritional value and other consumer benefits based on varieties which I helped develop is currently being marketed throughout Europe the US and Australia. I also played a key role in developing second generation rice products that cook even faster and which have even higher nutritional value. These are also currently on grocery shelves throughout Europe, the US, and Australia. A new line of research on rice nutrition that we have become involved in the last 18 months has will soon led to the first rice products that meet the official US requirements for labeling as a “good source of dietary fiber.” Microsatellite markers for alleles of granule bound starch synthase associated with different cooking and processing quality developed in my lab are routinely used in breeding programs around the world. Microsatellite markers for the blast resistance genes Pi-b, Pi-k Pi-ta2 and Pi-z that were developed in my lab are also being routinely used a number of rice breeding programs around the world. My lab played an important role in development of the first non-fortified rice products that meet the US standard for a “good source of dietary fiber”.

C. Research Support

Ongoing Research Support

May 2009 MARS, Inc. Mar 2012 Rice Variety Development Project $538,323

May 2009 Texas Rice Improvement Association April 2010 Cost Effective Application of Biotechnology to the Texas Rice Industry $35,500

PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page Curriculum Vitae

C. O. Patterson Professor of Biology Department of Biology, Texas A&M University College Station, Texas 77843-3258 phone (979) 845-2187 e-mail: [email protected] FAX: (979) 845-2891

EDUCATION: Postdoctorate Indiana University at Bloomington (1972-77), Microbiology Ph.D. University of Texas at Austin (1971), Zoology B.A. University of Texas at Austin (1964), Honors

ACADEMIC EXPERIENCE: 2006 - present Professor, Department of Biology, Texas A&M University 1984 - 2006 Associate Professor, Department of Biology, Texas A&M University. 1983 - 1984 Associate Professor, Department of Biology, Texas A&M University. Director of Freshman Biology Programs 1980 - 1983 Assistant Professor, Department of Biology, Texas A&M University. Director of Freshman Biology Programs. 1977 - 1980 Assistant Professor, Division of Biological Sciences, University of Missouri. Director of Introductory Biology 1975 - 1977 Research Associate (Post-Doctoral), Department of Microbiology, Indiana University 1972 - 1975 Visiting Assistant Professor, Division of Biological Sciences, Indiana University 1971 - 1972 Instructor, Department of Zoology, University of Texas. 1970 - 1971 Teaching Assistant, Department of Zoology, University of Texas 1967 - 1970 National Science Foundation Graduate Fellow, Dept of Zoology, Univ of Texas 1966 - 1967 Teaching Assistant, Department of Zoology, University of Texas.

OTHER EXPERIENCE: 1967 - 1970 Board of Directors, University Cooperative Society, Austin, Texas. 1964 Technician, Medical Pathology Laboratory, Hendricks Memorial Hospital, Abilene, Texas.

SOCIETY MEMBERSHIPS: Phi Beta Kappa, Sigma Xi, American Society of Plant Biologists, Phycological Society of America, American Association for the Advancement of Science, National Association of Biology Teachers, Texas Academy of Science

ADVANCED PLACEMENT: Reader, National Advanced Placement Biology Examination, Educational Testing Service, Princeton, NJ, 1986, 87, 88, 2004, 05, 06 Table Leader, National Advanced Placement Biology Examination, Educational Testing Service, 1989, 92, 94, 95, 96, 97, 98, 2000, 01 Question Leader, National Advanced Placement Biology Examination, Educational Testing Service, 1990, 91, and 93. Workshops for Advanced Placement Biology Teachers, sponsored by Educational Testing Service and College Board. Trained high school teachers in techniques of chloroplast isolation, measurement of Hill Reaction activity, use of computers in biology classrooms, simulations of DNA fingerprinting, analysis of water potential in biological systems, and other teaching techniques. Austin, Texas, 23-24 July 1989; Corpus Christi, Texas, 9-10 March 1990; Austin, 25-26 July 1990; Dallas, 12-13 April 1991; Austin, 25-26 July 1991; Tulsa, Oklahoma, 5-6 February 1997; Houston, 17 February 1997; Santa Fe, New Mexico, 27 February - 2 March 1997, Dallas, 23-24 June 1998, College Station. Texas, 10 February 2001, San Antonio, 21- 22 February 2003, Houston, 17 November 2004, San Antonio, 2 November 2005. Workshops for Advanced Placement Biology Teachers, sponsored by TAMU and The College Board. Trained high school teachers in all aspects of teaching college-level biology course in the high- school setting. Texas A&M University, 25-30 June 1995, 15-19 July 1996, 7-18 July 1997, 6 - 17 July 1998, 5-9 July 1999, 17-21 July 2000, 16-20 July 2001, 15-19 July 2002, 30 June- 4 July 2003, 19-23 July 2004, 18-22 July 2005, 17 - 21 July 2006, 16 - 20 July 2007, 14-18 July 2008. Workshops for PreAP Science Teachers, sponsored by TAMU and The College Board. Trained middle school and high school teachers to prepare students for entry into AP courses. Texas A&M University, 13-17 July 1998, 28-30 June 2004, 1-5 August 2005, 24 - 26 July 2006. Advisory Board, Southwest Region of the College Board, Austin, Texas, 1996-2000

PUBLICATIONS:

B.D. Etter and C.O. Patterson: Measurement of fluid mechanical properties of algal suspensions for engineering designs. in Regenerative Life Support Systems, O.W. Nicks, ed. SRC Report 5- 5873-3 NASA Johnson Space Center, NAG9-253. pp 126-131 (1989). M. Holtzapple, F.E. Little, M.E. Makela and C.O. Patterson: Analysis of an algae-based closed ecological life support system, Part I, Model Development. Acta Astronautica, 19: 353-364 (1989). M. Holtzapple, F.E. Little, W. Moses and C.O. Patterson: Analysis of an algae-based closed ecological life-support system, Part II, Options and weight analysis. Acta Astronautica, 19: 365-375 (1989). G.D. Hitchens, T.D. Rogers, O.J. Murphy, and C.O. Patterson: A new photocatalytic material based on algal cells. Biochemical and Biophysical Research Communications 175: 1029-1035 (1991). G.D. Hitchens, T.D. Rogers, O.J. Murphy, C.O. Patterson and R.H. Hearn: Deposition of Metallic Platinum in Blue Green Algae Cells. in Enzymatic Conversion of Biomass for Fuels Production, a Symposium of the American Chemical Society, ACS Symposium Series 556: Chapter 12, pp 246-254 (1994). C.O. Patterson, Carol Brown, David Castro, & Carol Leibl: AP Science Vertical Teams. in Advanced Placement Vertical Teams in Science, Social Studies, Foreign Language, Studio Art, and Music Theory: An Introduction. The College Board, 1999, pp14 – 20. C.O.Patterson: Harmful Algal Blooms: Toxic Algae and Algal Toxins. in Encyclopedia of Aquaculture, Robert Stickney, ed., John Wiley & Sons publishers, New York, pp17-25, (2000). R.D. VanPutte and C.O. Patterson: Micro-algal Plasma Membranes Purified by Aqueous Two-Phase Partitioning. Transactions of the Illinois State Academy of Science 96, 71-86 (2003). Wm. Bond, B. Briggs, F. Brown, M. Case, N. Ganguly, H.A.E. Howell, L. Kirby, C.O.Patterson, J. Schutter: The AP Vertical Teams Guide for Science. The College Board, New York, New York, 2004, 224 pages. (Authors are listed alphabetically.) C.O.Patterson et al.: Texas College Readiness Standards (Adopted by Texas Higher Education Coordinating Board, January 24, 2008) Complete list of authors at end of document. pdf version posted at J.J. Brand, D.W. Krogmann, and C.O. Patterson: Jack Edgar Myers (1913 - 2006), an algal physiologist par excellence. Photosynthesis Research 96: 9-14 (2008)

Principal Investigator/Program Director (Last, first, middle): Pillai, Suresh, D.

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE

Suresh D. Pillai Professor eRA COMMONS USER NAME

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

INSTITUTION AND LOCATION DEGREE YEAR(s) FIELD OF STUDY (if applicable) Loyola College, Madras B.Sc. 1983 Botany University of Madras M.Sc. 1985 Industrial Microbiology University of Arizona Ph.D. 1989 Microbiology & Immunology

A. Positions and Honors.

Positions and Employment 2004-present Professor and TAES Faculty Fellow, Food Safety & Environmental Microbiology Program, Poultry Science & Nutrition & Food Science Departments, Texas A&M University 2004-present Chair, Graduate Faculty of Biotechnology, Texas A&M University 2003-present Director, National Center for E-Beam Food Research, Texas A&M University 2000-2005 Associate Director, Institute of Food Science & Engineering, Texas A&M University 2000-2004 Associate Professor & TAES Faculty Fellow -Food Safety and Environmental Microbiology Program, Poultry Science Dept. Texas A&M University 2000-present Member of Graduate Faculties of Poultry Science, Food Science & Technology, Biotechnology, Veterinary Pathobiology, Toxicology, Soil & Crop Sciences, and Water Program at Texas A&M University. 1998-1999 Associate Professor, Texas A&M Univ. Research Center, El Paso, and Soil and Crop Sciences, Texas A&M University, College Station, Texas. also Member, Graduate Faculty, Biology Dept., New Mexico State University, Las Cruces, New Mexico Member, Graduate Faculty, Biology Dept., University of Texas at El Paso. TX 1992- 1998 Assistant Professor, Texas A&M Univ. Research Center, El Paso, and Soil and Crop Sciences, Texas A&M University, College Station, Texas. 1991-1992 Research Scientist - Accelerated Products Development Program, Naval Medical Research Institute, Bethesda, MD.

Honors 2008 President’s Travel Fund Award- Society for Applied Microbiology (SFAM) 2008 Distinguished Lecturer, Institute of Food Technologists (IFT) 2007 Distinguished Lecturer, Institute of Food Technologists (IFT) 2007 Texas Environmental Excellence Award (Team-member) 2006- Member, Scientific Advisory Board, Department of Homeland Security Center for Advanced Microbial Risk Assessment 2006- Expert Panel Member, Govt. Accountability Office (GAO), Washington, DC.

PHS 398 (Rev. 11/07) Page ___ Biographical Sketch Format Page

Principal Investigator/Program Director (Last, first, middle): Pillai, Suresh, D. 2004- Elected Member, Council of Principal Investigators, Texas A&M University 2003-2007 Member, Scientific Advisory Board, Warnex, Inc. 2002 TAES Faculty Fellow, Agriculture Program, Texas A&M University

B.Technology Commercialization Efforts 2009 High energy electron beam for disinfection of municipal biosolids. Suresh D. Pillai and Alexis Lazarine (provisional patent-submitted) 2009 High energy electron beam irradiation for the production of immuno-modulators in poultry. Jack McReynolds and Suresh D. Pillai (provisional patent-submitted) 2007 Removal of biological pathogens using surfactant-modified zeolites. Dirk Schulze-Makuch, Robert S. Bowman and Suresh D. Pillai. U.S. Patent 7,311,839

C. Peer-reviewed publications (since 2008) * represents Pillai’s students and post-doctoral fellows, Ágoston, R*., K.A. Soni*, P. Jesudhasan*, W.Russell, C.M. Farkas, and S.D. Pillai (2009) Differential Expression of Proteins in Listeria monocytogenes under Thermo Tolerance-Inducing, Heat Shock, and Prolonged Heat Shock Conditions. Foodborne Pathogens and Disease (in press) Ágoston, R*, C.M. Farkas and S.D. Pillai (2009) Exposure to sub-lethal temperatures induces enhanced heat resistance in Listeria monocytogenes. Acta Alimentaria (in press) Ágoston, R*., K.A. Soni*, K. McElhany*, M.L. Cepeda*, U. Zuckerman, S. Tzipori, C.M. Farkas, and S.D. Pillai (2009) Rapid Concentration of Bacillus and Clostridium Spores from Large Volumes of Milk using Continuous Flow Centrifugation. Journal of Food Protection 72: 666-669 Girennavar B, Cepeda ML, Soni KA*, Vikram A, Jesudhasan P*, Jayaprakasha GK, Pillai SD, Patil BS. 2008. Grapefruit juice and its furocoumarins inhibits autoinducer signaling and biofilm formation in bacteria. International Journal of Food Microbiology. 125:204-208. Epub 2008 Alali WQ, Scott HM, Harvey RB, Norby B, Lawhorn DB, Pillai SD. 2008. Longitudinal study of antimicrobial resistance among Escherichia coli isolates from integrated multisite cohorts of humans and swine.Applied and Environmental Microbiology. 74: 3672-3681 Mackay, W.A., B. Pemberton, J. Maxim* and S.D. Pillai. (2008). Ionizing Irradiation Using E-Beam to Control Importation of Biothreat Agents in Geranium Cuttings Inhibits Rooting. HortScience 43:955-956. Mena, K., and S.D. Pillai (2008). An Approach for Developing Quantitative Risk-based Microbial Standards for Fresh Produce. Journal of Water Health 6: 359-364 Soni, K*., P.R. Jesudhasan*, M.L.Cepeda*, B. Williams, M. Hume, W.K. Russell, A. Jayaraman, and S.D. Pillai. (2008). Autoinducer AI-2 is involved in regulating a variety of cellular processes in Salmonella Typhimurium. Foodborne Pathogens and Disease 5:147-153

C. Research Support. (current) Co-Investigator – Phase II STTR Program –Department of Homeland Security. Cold Cathode Radiation for blood. $ 147,903 (9/2008-8/2009) Principal Investigator - Disinfecting and Stabilizing Biosolids Using E-beam and Chemical Oxidants. Principal Investigator. Water Environment Research Foundation. $ 183,903 (4/2007-3/2009) Co-Investigator - Development and Evaluation of Flat Panel X-ray Source - Advanced Technology Program of the National Institute of Standards and Technology (NIST) -$2,000,000 (2/2007-10/2009) Principal Investigator - Concentrating bacterial spores from milk and juices using dielectrophoresis based microfluidic capture systems. Principal Investigator. DHS/ National Center for Food Protection and Defense- University of Minnesota. (9/07-12/09) $230,000

PHS 398 (Rev. 11/07) Page ___ Continuation Format Page

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Rathore, Keerti S. Associate Professor eRA COMMONS USER NAME Rathore EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) Rajasthan University, India B.Sc. 1973 Zoology, Botany, Chemistry Gujarat University, India M.Sc. 1976 Plant Sciences Imperial College, University of London Ph.D. 1981 Plant Physiology

A. Positions and Honors.

Positions and Employment 1982-1984 Postdoctoral Research Associate, Dept. of Pure and Applied Biology, Imperial College, London, U.K. 1985-1990 Postdoctoral Research Associate, Dept. of Biological Sciences, Purdue University, W. Lafayette, IN. 1991-1995 Research Scientist, Dept. of Botany and Plant Pathology, Purdue University, W. Lafayette, IN. 1995-1997 Asst. Research Scientist Crop Biotechnology Center & Dept. of Soil and Crop Sciences, Texas A&M University, College Station, TX. 1997-2003 Assistant Professor, Institute for Plant Genomics & Biotechnology and Dept. of Soil & Crop Sciences, Texas A&M University 2003- Associate Professor, Institute for Plant Genomics & Biotechnology and Dept. of Soil & Crop Sciences, Texas A&M University

Other Experience

1995-1997 Director, Laboratory for Crop Transformation, Crop Biotechnology Center, Texas A&M University, College Station, TX 1997-Present Director, Laboratory for Crop Transformation, Institute for Plant Genomics & Biotechnology, Texas A&M University, College Station, TX

B. Selected peer-reviewed publications KUMAR, V., PARKHI, V., KENERLEY, C. & RATHORE K. S. (2009) Defense-related gene expression and enzyme activities in transgenic cotton plants expressing an endochitinase gene from Trichoderma virens in response to interaction with Rhizoctonia solani. Planta 230: 277-291.

SUNILKUMAR, G., WAGHELA, S. D., CAMPBELL, L. M. & RATHORE K. S. (2009) Expression of anti-K99 scFv in transgenic rice tissues and its functional characterization. Transgenic Reseach 18: 347-360.

PARKHI, V., KUMAR, V., SUNILKUMAR, G., CAMPBELL, L. M., SINGH, N. K. & RATHORE K. S. (2009) Expression of apoplastically secreted tobacco osmotin in cotton confers drought tolerance. Molecular Breeding 23: 625-639.

REN, S, MANDADI, K. K., BOEDEKER, A. L., RATHORE K. S. & MCKNIGHT, T. D. (2007) Regulation of telomerase in Arabidopsis by BT2, an apparent target of TELOMERASE ACTIVATOR1. Plant Cell 19: 23- 31.

SUNILKUMAR, G., CAMPBELL, L. M., PUCKHABER, L. & RATHORE K. S. (2006) Engineering cottonseed for use in human nutrition by tissue-specific reduction of toxic gossypol. Proceedings of the National Academy of Sciences, USA 103: 18054-18059.

BURRELL, A. M., LINEBERGER, R. D., RATHORE K. S. & BYRNE, D. H. (2006) Genetic variation in somatic embryogenesis of rose. Hortscience 41: 1165-1168.

SUNILKUMAR, G., CAMPBELL, L. M., MONJUR, H. M., CONNELL J. P., HERNANDEZ, E., REDDY A. S., SMITH C. W. & RATHORE K. S. (2005) A comprehensive study of the use of a homologous promoter in antisense cotton lines exhibiting high seed-oleic acid phenotype. Plant Biotechnology Journal 3: 319- 330.

JAY, C. M., BHASKARAN, S., RATHORE, K. S. and WAGHELA, S. D. (2004) Enterotoxigenic K99+ Escherichia coli attachment to host cell receptors inhibited by recombinant pili protein. Veterinary Microbiology 101: 153-160.

EMANI, C., GARCIA, J. M., LOPATA-FINCH, E., POZO, M., URIBE, P., KIM, D-J., SUNILKUMAR, G., COOK, D. R., KENERLEY, C. M. and RATHORE, K. S. (2003) Enhanced fungal resistance in transgenic cotton expressing an endochitinase gene from Trichoderma virens. Plant Biotechnology Journal 1: 321-336.

SUNILKUMAR, G., MOHR, L., LOPATA-FINCH, E., EMANI, C. and RATHORE, K. S. (2002) Developmental and tissue-specific expression of CaMV 35S promoter in cotton as revealed by GFP. Plant Molecular Biology 50: (3) 463-474.

SUNILKUMAR, G., CONNELL, J. P., SMITH, C. W., REDDY, A. S., and RATHORE, K. S. (2002) Isolation and functional characterization of alpha-globulin promoter from cotton in transgenic cotton, Arabidopsis and tobacco. Transgenic Research 11: 347-359.

EMANI, C., SUNILKUMAR, G. and RATHORE, K. S. (2002) Transgene silencing and reactivation in sorghum. Plant Science: 162:181-192.

SUNILKUMAR, G. AND RATHORE, K. S. (2001) Transgenic cotton: factors influencing Agrobacterium- mediated transformation and regeneration. Molecular Breeding 8 (1): 37-52.

Book Chapters:

RATHORE K. S., SUNILKUMAR, G., CANTRELL, R. G., HAGUE, S. & REDING H.K. (2008) Cotton. In: Compendium of Transgenic Crop Plants, Vol. 7: Transgenic Sugar, Tuber and Fiber Crops, eds. C. Kole and T. C. Hall (Wiley-Blackwell. Chichester, West Sussex, UK), pp. 199-238.

RATHORE, K. S. (2007) Cotton. In: Biotechnology in Agriculture and Forestry, Vol. 343: Transgenic Crops VI, eds. E. C. Pua and M. R. Davey (Springer, Berlin, Heidelberg, New York), pp. 107-127.

RATHORE, K. S., SUNILKUMAR, G. & CAMPBELL, L. M. (2006) Cotton (Gossypium hirsutum L.). In: Methods in Molecular Biology, Vol. 343: Agrobacterium Protocols, 2nd Ed., Vol 1, ed. K. Wang (Humana Press Inc. Totowa, NJ), pp. 267-279.

RATHORE, K. S., SUNILKUMAR, G., PUCKHABER, L., STIPANOVIC, R. D., MONJUR, H. M., HERNANDEZ, E., and SMITH, C. W. (2003) Improvements in the nutritional quality of the cottonseed. Plant Biotechnology 2002 and Beyond. ed. I. K. Vasil. (Kluwer Academic Publishers, Dordrecht), pp. 417-420.

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Russell, David H. Professor of Chemistry eRA COMMONS USER NAME davidrussell EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable)

University of Arkansas-Little Rock BS 1974 Chemistry University of Nebraska Ph.D 1974-1978 Chemistry

A. Positions and Honors Research Scientist, Oak Ridge National Laboratory, Division of Analytical Chemistry 1978-1980 Assistant and Associate Professor, Texas A&M University 1980-1989 Chairman, Analytical Chemistry Division, Texas A&M University 1987-1990 Professor, Texas A&M University 1989-present Director, Laboratory for Biological Mass Spectrometry, Texas A&M University 1994-present Co-Director, Center for Structural Biology 2001-present AB/MDS Sciex Professor of Mass Spectrometry 2002-present Head, Department of Chemistry, Texas A&M University Oct 2006 – Sept 2010

HONORS: National Science Foundation/Am. Society of Mass Spectrometry Foreign Travel Award National Science Foundation, Two Year Extension for Special Creativity TL Minnesota Chromatography Forum, Special Recognition Fellow of the American Association for the Advancement of Science 2004 Distinguished Achievement Award for Research B. Selected peer-reviewed publications (total of 230 publications) “Experimental and Theoretical Studies of (CsI)(n)Cs+ Cluster Ions Produced by 355 nm Laser Desorption Ionization,” Francisco A. Fernandez-Lima, Christopher Becker, Kent Gillig, William K. Russell, M. Nascimento, David H. Russell, J. Phys. Chem. A, 2008 112, 11061-11066. “Unimolecular Dissociation Reactions of Methyl Benzoate Radical Cation,” Yiqun Huang, Scott Peterman, Shane Tichy, Simon North, David H. Russell, J. Phys. Chem. A, 2008 112, 11590-11597. “A New Copper Containing MALDI Matrix That Yields High Abundances of [Peptide + Cu](+) Ions,” Zhaoxiang Wu, Francisco Fernandez-Lima, L. M. Perez, David H. Russell, JASMS, 2009 20, 1263-1271. “On the Structure Elucidation Using Ion Mobility Spectrometry and Molecular Dynamics,” Francisco Frenandez-Lima, H. Wei, Y.Q Gao, David H. Russell, J. Phys. Chem. A, 2009 113, 8221-8234. “A Novel Approach to Collision-Induced Dissociation (CID) for Ion Mobility-Mass Spectrometry Experiments,” Christopher Becker, Francisco Fernandez-Lima, Kent J. Gillig, William K. Russell, Stephanie C. Cologna, David H. Russell, JASMS, 2009 20, 907-914. “Ion Mobility-Mass Spectrometry: A Tool for Characterizing the Petroleome,” Christopher Becker, Francisco Fernandez-Lima, David H. Russell, Spectroscopy, 2009 24, 38-42. “Liver Proteome Analysis in a Rodent Model of Alcoholic Steatosis,” B. W. Newton, William K. Russell, David H. Russell, S. K. Ramaiah, A. Jayaraman, Journal of Proteome Research, 2009, 8, 1663- 1671.

“Neuropeptides in Heteroptera: Identification of allatotropin-related peptide and tachykinin-related

PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Biographical Sketch Format Page peptides using MALDI-TOF Mass Spectrometry,” S. Neupert, William K. Russell, David H. Russell, J. D. Lopez, R. Predel, R. J. Nachman, Peptides, 2009 30, 483-488. “Anion Effects on Ionization Efficiency Using Gold Nanoparticles as Matrices for LDI-MS,” Katherine A. Stumpo, David H. Russell, J. Phys. Chem. C, 2009 113, 1641-1647. “Ion Mobility-Mass Spectrometer Interface for Collisional Activation of Mobility Separated Ions,” Francisco Fernandez-Lima, Christopher Becker, Kent J. Gillig, William K. Russell, Shane E. Tichy, David H. Russell, Anal. Chem., 2009 81, 618-624.

PATENTS Gillig, Kent J.; Russell, David H. A periodic field focusing ion mobility spectrometer. PCT Int. Appl. (2001) 36 pp. CODEN: PIXXD2 WO 0165589 A1 20010907 CAN 135:233637 AN 2001:661741 CAPLUS Fuhrer, Katrin; Gonin, Marc; Gillig, Kent; Russell, David H.; Schultz, John A. Improved mobility spectrometer. PCT Int. Appl. (2001) 63 pp. CODEN: PIXXD2 WO 0164320 A1 20010907 CAN 135:232944 AN 2001:661302 CAPLUS McLean, John and Russell, David H., Advanced Optics for Rapidly Patterned Laser Profiles in Analytical Mass Spectrometry. (2004) McLean, John A. and Russell, David H., Gas-Phase Purification of Biomolecules by Ion Mobility for Patterning Microarrays and Protein Crystal Growth. (2004) McLean, John A.; Russell, David H.; Egan, Thomas F., Ugarov, M.V.; Schultz, J. Albert, Multiplex Data Acquisition Modes for Ion Mobility-Mass Spectrometry. (2004)

C. Research Support Robert A. Welch Foundation, “Studies of the Structure Gas-Phase Peptide Ions” 06/01/07 – 05/31/10 $50,000 This proposal describes studies aimed at understanding intramolecular interactions of gas-phase peptide ions and how such interactions affect structure(s) and reactivity (unimolecular and bimolecular (H/D exchange ion-molecule reactions)). Department of Energy, “Nanoparticle Laser Desorption Ionization and IM-MS Applied Structural Mass Spectrometry” 04/01/07 – 03/31/10 $140,000 This research is aimed at fundamental studies of ions formed by MALDI with emphasis on internal energies and structure(s) of the ions. The ions investigated include protonated molecules, [M + H]+ ions, as well as model compounds with alkali and transition metal ions attached, esp. [M + Na]+ and [M + Cu]+ ions. National Science Foundation (DBI0821700) MRI – “Development of Ion Mobility Mass Spectrometer for Protein Chemistry” 09/01/08-08/31/2012 $1,450,000 The primary research goal is to continue the development of ion mobility-mass spectrometry (IM-MS) for the high-throughput analysis of complex mixtures; specifically IM-MS and IM-MS/MS methods will be developed to enhance throughput, sensitivity, and information content when compared to traditional mass spectrometric analysis. The proposed instrumental changes will result in ca. 2-fold increase in ion mobility resolution and ca. 10-fold increase in the number of ions that are transmitted to the mass analyzer over the current instrument. The proposal outlines the development of data acquisition and analysis software which will improve peak picking, trend line analysis, determination of absolute collision cross-sections, and library searching on the 2D IM-MS data, figures-of-merit which are essential to realize the full potential of the high throughput capabilities of this proteomic platform. The development of such software will facilitate the creation of a public domain database for peptide sequence-structure and peptide-ligand interactions which will be used to enhance the confidence of protein identification. The driving forces behind this proposal are real samples from chemistry, chemical-biology, and biochemistry research.

BIOGRAPHICAL SKETCH Provide the following information for all key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME POSITION TITLE SAFE, Stephen H. Distinguished Professor eRA COMMONS USER NAME ssafe1

EDUCATION (Begin with baccalareate or other initial professional education, such as nursing, and include postdoctoral training.)

INSTITUTION AND LOCATION DEGREE YEAR(s) FIELD OF STUDY

Queen's University - Canada B.S. 1962 Chemistry Queen's University - Canada M.S. 1963 Chemistry Oxford University - Great Britain D.Phil. 1965 Bioorganic Chemistry Oxford University - Great Britain Res. Asst. 1966 Bioorganic Chemistry Harvard University - USA Res. Assoc. 1967 Biochemistry

A. POSITIONS AND HONORS

Professional Experience 1968-1973 Research Officer, National Research Council of Canada 1973-1981 Associate to Full Professor, Department of Chemistry, University of Guelph 1981-1984 Professor, Department of Veterinary Physiology & Pharmacology, Texas A&M University 1984- Distinguished Prof., Dept. of Veterinary Physiology & Pharmacology, Texas A&M University 2001- Director, Center for Environmental & Genetic Medicine, Institute of Biosciences & Technology, Texas A&M Health Science Center

Honors and Awards 1976 - Sigma Xi Award for Excellence in Research, University of Guelph; 1978 - Queen's Silver Jubilee Medal; 1984 - Royal Society of Chemistry Award for Safety, Health or Environmental Chemistry; 1988 - Distinguished Achievement Award in Research, Texas A&M University; 1989-1994 - Burroughs Wellcome Toxicology Scholar Award; 1991 - Sid Kyle Chair in Toxicology, Texas A&M University; 1991-1992 - University Lecturer, Texas A&M University; 1995 - Distinguished Achievement Award in Research, Sigma XI; 1995 - Eli Lilly Science and Society Lecturer, Indiana State University; 1996 - Samuel Kuna Distinguished Lecturer, Rutgers University - UMDNJ; 1996 - Honorary Doctorate in Science, University of Guelph; 1998 - McEwen Lecturer, Queen’s University; 2002 - ISI, Most Highly Cited Research in Pharmacology and in Ecology/Environment; 2003 - Spirit of Innovation Award, Technology Licensing Office, Texas A&M University; 2004 - Jo Ann Treat Award for Excellence in Research, Texas A&M Research Foundation; 2005 - Texas A&M University Former Students Association Distinguished Achievement Award for Research; 2006 - Regents Professor, Texas A&M University System; 2007 - Distinguished Lifetime Toxicology Scholar Award, Society of Toxicology

B. SELECTED REPRESENTATIVE PUBLICATIONS (Refereed - >600; Books - 5) Abdelrahim, M., Baker, C.H., Abbruzzese, J.L., Sheikh-Hamad, D., Liu, S., Cho, S.D., Yoon, K. and Safe, S. Regulation of vascular endothelial growth factor receptor-1 (VEGFR1) expression by specificity proteins 1, 3 and 4 in pancreatic cancer cells. Cancer Res. 67:3286-3294, 2007. PMC17409437 Chintharlapalli, S., Papineni, S., Jutooru, I., McAlees, A. and Safe, S. Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator-activated receptor γ agonists in colon cancer cells. Mol. Cancer Ther. 6:1588-1598, 2007. PMC17513608 Chintharlapalli, S., Papineni, S., Liu, S., Jutooru, I., Chadalapaka, G., Cho, S.D., Murthy, R.S., You, Y. and Safe, S. 2-Cyano-lup-1-en-3-oxo-20-oic acid, a cyano derivative of betulinic acid, activates peroxisome proliferator-activated receptor γ in colon and pancreatic cancer cells. Carcinogenesis 28:2337-2346, 2007. PMC17724373 Su, Y., Vanderlaag, K., Ireland, C., Ortiz, J., Grage, H., Safe, S. and Frankel, A. 1,1-Bis(3'-indolyl)-1-(p- biphenyl)methane inhibits basal-like breast cancer growth in athymic nude mice. Breast Cancer Res. 39:289-304, 2007. PMC17764562 Khan, S., Wu, F., Liu, S., Wu, Q. and Safe, S. Role of specificity protein transcription factors in estrogen- induced gene expression in MCF-7 breast cancer cells. J. Mol. Endocrinol. 39:289-304, 2007. PMC17909268 Mertens-Talcott, S.U., Chintharlapalli, S., Li, X. and Safe, S. The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells. Cancer Res. 67:11001-11011, 2007. PMC18006846 Vanderlaag, K., Su, Y., Frankel, A.E, Grage, H., Smith, R. 3rd, Khan, S. and Safe, S. 1,1-Bis(3'-indolyl)-1-(p- substituted phenyl)methanes inhibit proliferation of estrogen receptor-negative breast cancer cells by activation of multiple pathways. Breast Cancer Res. Treat. 109:273-283, 2007. PMC17624585 Papineni, S., Chintharlapalli, S. and Safe, S. Methyl 2-cyano-3,11-dioxo-18β-olean-1,12-dien-30-oate is a peroxisome proliferator-activated receptor γ agonist that induces receptor-independent apoptosis in LNCaP prostate cancer cells. Mol. Pharmacol. 73:553-565, 2008. PMC17989348 Cho, S.D., Lei, P., Abdelrahim, M., Yoon, K., Liu, S., Guo, J., Papineni, S., Chintharlapalli, S. and Safe, S. 1,1- Bis(3'-indolyl)-1-(p-methoxyphenyl)methane activates Nur77-independent proapoptotic responses in colon cancer cells. Mol. Carcinog. 47:252-263, 2008. PMC17957723 Higgins, K.J., Liu, S., Abdelrahim, M., Vanderlaag, K., Liu, X., Porter, W., Metz, R. and Safe, S. Vascular endothelial growth factor receptor-2 expression is downregulated by 17β-estradiol in MCF-7 breast cancer cells by estrogen receptor α/Sp proteins. Mol. Endocrinol. 22:388-402, 2008. PMC:2234589 Chadalapaka, G., Jutooru, I., McAlees, A., Stefanac, T. and Safe, S. Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives. Bioorg. Med. Chem. Lett. 18:2633-2639, 2008. PMC:2408873 Hong, J., Samudio, I., Chintharlapalli, S. and Safe, S. 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes decrease mitochondrial membrane potential and induce apoptosis in endometrial and other cancer cell lines. Mol. Carcinog. 47:492-507, 2008. PMC:2711558 Wu, F., Khan, S., Wu, Q., Barhoumi, R., Burghardt, R. and Safe, S. Ligand structure-dependent activation of estrogen receptor α/Sp by estrogens and xenoestrogens. J. Ster. Biochem. Mol. Biol. 110:104-115, 2008. PMC:2519242 Chadalapaka, G., Jutooru, I., Chintharlapalli, S., Papineni, S., Smith III, R., Li, X. and Safe, S. Curcumin decreases specificity protein (Sp) expression in bladder cancer cells. Cancer Res. 68:5345-5354, 2008. PMC:2587449 Lei, P., Abdelrahim, M., Cho S.D., Liu, S., Chintharlapalli, S. and Safe, S. 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through activation of c-Jun N-terminal kinase. Carcinogenesis 29:1139-1147, 2008. PMC:2574736 Safe, S., Papineni, S. and Chintharlapalli, S. Cancer chemotherapy with indole-3-carbinol, bis(3'- indolyl)methane and synthetic analogs. Cancer Lett. 269:326-338, 2008. PMC:2574232 Cho, S.D., Chintharlapalli, S., Abdelrahim, M., Papineni, S., Liu, S., Guo, J., Lei, P., Abudayyeh, A. and Safe, S. 5,5'-Dibromo-bis(3'-indolyl)methane induces Krüppel-like factor 4 and p21 in colon cancer cells. Mol. Cancer Ther. 7:2109-2120, 2008. PMC:2565496 Wu, F., Xu, R., Kim, K., Martin, J. and Safe, S. In vivo profiling of estrogen receptor/specificity protein- dependent transactivation. Endocrinology 149:5696-5705, 2008. PMC:2584598 Lei, P., Abdelrahim, M., Cho, S.D. and Safe, S. Structure-dependent activation of endoplasmic reticulum stress-mediated apoptosis in pancreatic cancer by 1,1-bis(3'-indolyl)-1-(p-substituted phenyl)methanes. Mol. Cancer Therap. 7:3363-3372, 2008. PMC:2587030 Lee, S.H., Bahn, J.H., Choi, C.K., Whitlock, N.C., English, A.E., Safe, S. and Baek, S.J. ESE-1/EGR-1 pathway plays a role in tolfenamic acid-induced apoptosis in colorectal cancer cells. Mol. Cancer Therap. 7:3739-3750, 2008. PMC:2643071 Safe, S. and Kim, K. Nonclassical genomic ER/Sp and ER/Ap-1 signaling pathways. J. Mol. Endocrinol. 41:263-275, 2008. PMC:2582054 Inamoto, T., Papineni, S., Chintharlapalli, S., Cho, S.D., Safe, S. and Kamat, A.M. 1,1-Bis(3'-indolyl)-1-(p- chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth. Mol. Cancer Ther. 7:3825-3833, 2008. NIHMS:85688 BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE James E. Samuel Professor eRA COMMONS USER NAME (credential, e.g., agency login) SAMUELJ EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) Miami University B.A. 1976 Zoology & Chemistry Washington State University M.S. 1983 Biology Washington State University Ph.D. 1986 Microbiology Uniformed Services University Post-Doc 1987-1990

A. PROFESSIONAL EXPERIENCE: PROFESSIONAL EXPERIENCE 1977-78 Chemist 1979-83 Research technician, Battelle Pacific Northwest Labs 1983-86 Graduate Research Assistant, Dept. Micro, Washington State Univ., Pullman, WA. 1987 Lecturer, Microbiology, Washington State University 1987 Post-doctoral Fellowship, Washington State University 1987-1990 Post-doctoral Fellowship, Uniformed Services Univ., Bethesda, MD 1990-1991 Senior Scientist, BioCarb Inc., Gaithersburg, MD 1991-1994 Director, Molecular Biology, MicroCarb Inc., Gaithersburg, MD 1994-2000 Assistant Professor, Dept. of Med. Micro. College of Medicine, TAMUSHSC 2000-2005 Associate Professor, Dept. of Med. Micro. , College of Medicine, TAMUSHSC 2005-Present Professor, Dept. of Med. Micro. , College of Medicine, TAMUSHSC 2006-Present Associate Dept. Head, Dept. of Micro. & Mol. Pathogenesis, TAMUSHSC HONORS Battelle Pre-doctoral Fellowship, 1983-1986 Battelle Post-doctoral Fellowship, 1987 National Institutes of Health, National Research Service Award Post-doctoral Fellowship, 1988-1990 Top 100 Research & Development Patent of 1990 President, American Society of Rickettsiology, 2007-2009

B. SELECTED PUBLICATIONS: LAST 3 YEARS (From list of 88)

Beare, P.A., J.E. Samuel, D. Howe, K. Vitaneva, S.F. Porcella, and R.A. Heinzen. Genetic diversity of the Q fever agent, Coxiella burnetii, assessed by microarray-based whole-genome comparisons. 2006. J. Bacteriol. 188: 2309-2324.

Russell-Lodrigue, K.E., D.N. McMurray, and J.E. Samuel. Clinical and pathologic changes in a guinea pig aerosol-challenge model of acute Q fever. 2006. Infect. Immun.74:6085-6091.

Coleman, S.A, E.R. Fischer, D.C. Cockrell, D.E. Voth, D. Howe, D.J. Mead, J.E. Samuel and B.A. Heinzen. Proteome and antigen profiling of Coxiella burnetii developmental forms. 2007. Infect Immun. 75: 290-298.

Andoh, M., G. Zhang, K.E. Russell-Lodrigue, H. R. Shive, B.R. Weeks, and J.E. Samuel. T cells are essential for bacterial clearance, and gamma interferon, tumor necrosis factor alpha, and B cells are crucial for disease development in Coxiella burnetii infection in mice. 2007. Infect. Immun. 75. 3245-3255.

PHS 398/2590 (Rev. 11/07) Page ___ Other Support Format Page Zhang, G.Q., K.E. Russell-Lodrique, M. Andoh, Y. Zhang, L.R. Hendrix, J.E. Samuel. Mechanisms of vaccine- induced protective immunity against Coxiella burnetii infection in BALB/c mice. 2007. J. Immunol. 179:8372- 8380.

Briggs, H., N. Pul, R. Seshadri, M.J. Wilson, C. Tersteeg, K.E. Russell-Lodrique, M. Andoh, A.J. Baumler, and J.E. Samuel. A limited role for iron regulated genes in Coxiella burnetii pathogenesis. 2008. Infect. Immun. 76:2189-2201.

Mertens, K., L. Lantsheer, D.G. Ennis, and J.E. Samuel. Constituitive SOS expression and damage-inducible AddAB-mediated recombinational repair systems for Coxiella burnetii as potential adaptations for survival within macrophages. 2008. Mol. Microbiol.69: 1411-1426. PMID18647165.

P.A. Beare, C. Chen, T. Bouman, J. Pablo, B. Unal, 4 D.C. Cockrell, W.C. Brown, K.D. Barbian, S.F. Porcella, J.E. Samuel, P.L. Felgner, and R.A. Heinzen. Candidate Q fever serodiagnostic antigens revealed by immunoscreening a Coxiella burnetii protein microarray. 2008. Clin. Vac. Immunol.15:1771-1779. PMID18845831.

P.A. Beare, N. Unsworth, M. Andoh, D.E. Voth, A. Omsland, S.D. Gilk, K.P. Williams, B.W. Sobral, J.J. Kupko, Porcella, J.E. Samuel and R.A. Heinzen. Comparative genomics reveal extensive transposon-mediated genomic plasticity and diversity among potential effector proteins within the genus Coxiella. 2009. Infect. Immun. 77:642-656. PMID19047403.

Chen C, Bouman TJ, Beare PA, Mertens K, Zhang GQ, Russell-Lodrigue KE, Hogaboam JP, Peters B, Felgner PL, Brown WC, Heinzen RA, Hendrix LR, Samuel JE. Candidate antigens for Q fever serodiagnosis revealed by immunoscreening of a Coxiella burnetii protein microarray. 2009 Clin. Microbiol. Infect. PMID: 19281461

Voth, DE, D Howe, PA Beare, JP Vogel, N. Unsworth, JE Samuel, RA Heinzen. The Coxiella burnetii ankyrin repeat domain-containing protein family is heterogeneous with C-terminal truncations that influence Tot/Icm-mediated secretion. 2009. J. Bacteriol. 191:4232-4242. PMID: 19411324

C. RESEARCH SUPPORT. Ongoing Research Support: RO1 AI037744 (Samuel, J.E., PI) NIH/NAIAD 7/1/03-12/31/09 no cost extension PATHOGENIC ROLES OF COXIELLA BURNETII PROTEINS

RO1 AI057768 (Samuel, J. E., PI) NIH/NAIAD 2/15/05-1/31/10 1.2 calendar months IDENTIFICATION OF T CELL ANTIGENS FOR Q FEVER VACCINATION

NO1-AI-40027 NIH/NIAID (Hildebrand, PI) 10/1/06-9/30/09 0.6 calendar months HLA CLASS I EPITOPES ASSOCIATED WITH Q FEVER (J.E. Samuel Subcontract)

W81XWH-07-1-0304 DOD-U.S. Army Med Res ACQ. (Ficht, A., PI) 3/12/07-3/11/2010 1.2 calendar months MICROENCAPSULATION & VACCINE DELIVERY RESEARCH. (Samuel, Co-PI) 1.2 calendar months

AI078213 NIH/NIAID (Felgner, PI) 10/1/08-9/30/13 0.6 calender months A MULTIPLEX SERODIAGNOSTIC PROTEIN MICROARRAY. (J.E. Samuel Subcontract)

U54 AI057156 NIH/NAIAD (Walker, D.H., PI) 3/1/2009-2/27/2014 1.8 calendar months SOUTHWEST RCE: VACCINE DEVELOPMENT AGAINST Q FEVER (J.E. Samuel, Major Project)

PHS 398/2590 (Rev. 11/07) Page ___ Other Support Format Page Principal Investigator/Program Director (Last, First, Middle): Sayes, Christie

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Sayes, Christie M Assistant Professor of Veterinary Physiology & eRA COMMONS USER NAME Pharmacology and Biomedical Engineering CMSAYES EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) Louisiana State University B.S. 1997-2001 Chemistry Rice University Ph.D. 2001-2005 Chemistry DuPont Haskell Global Centers Post-doc 2005-2007 Toxicology

A. Positions and Honors. Positions December 2000-May 2001 Technical Support Scientist, Louisiana State University May 2001- December 2003 Teaching Assistant, Rice University December 2005-December 2007 Post-doctoral Fellow, Visiting Scientist, the DuPont Company January 2008-present Assistant Professor of Vet. Phys. & Pharm., TAMU January 2008-present Member of Intercollegiate Faculty of Toxicology (IFT), TAMU January 2008-present Member of the Faculty of Material Sciences & Engineering, TAMU February 2009-present Executive Committee Member of IFT, TAMU April 2009-present Adjunct Appointment in Biomedical Engineering, TAMU April 2009-present Adjunct Appointment in the Institute of Biosciences, TAMHSC May 2009-present Secretary of the Gulf Coast Chapter of the Society of Toxicology May 2009-present Member of Graduate Faculty of the Biotechnology Program, TAMU

Other Experience and Professional Memberships 2001-present American Chemical Society 2004-present Society of Toxicology 2005-present Society of Environmental Toxicology and Chemistry

Honors 2001 Welch Fellowship Supplemental Award 2004 Harry B. Weiser Graduate Student Award for Research 2004 Houston Livestock and Rodeo Endowed Scholarship 2005 1st International Toxicology of Nanomaterials: Young Investigator Award 2006 Society of Toxicology, Inhalation Specialty Section, Postdoctoral Award 2007 Society of Toxicology, Best Post-doctoral Publication Award 2008 EMPA Nano-Eco Young Investigator Award 2009 Searle Scholars Program, Texas A&M University Representative 2009 BWF Investigators in Pathogenesis of Infectious Disease, Texas A&M University Nominee

B. Selected peer-reviewed publications (in chronological order) (Publications selected from 30 peer-reviewed publications) Sayes CM, Fortner JD, Guo W, Lyon D, Boyd A, Ausman KD, Tao Y, Sitharaman B, Wilson LJ, Hughes J, West JL, Colvin VL; “The differential cytotoxicity of water-soluble fullerenes”. NanoLett. 4(10):1881 (2004). Chen M, Falkner J, Guo WH, Zhang JY, Sayes CM, Colvin VL; “Synthesis and self-organization of soluble monodisperse palladium nanoclusters”. Journal of Colloid and Interface Science 287(1):146 (2005).

PHS 398/2590 (Rev. 09/04) Page 1 Continuation Format Page

Principal Investigator/Program Director (Last, First, Middle): Sayes, Christie

Sayes CM, Gobin AM, Mendez J, West JL, Colvin VL; “Nano-C60 cytotoxicity is due to lipid peroxidation”. Biomaterials 27(5):7587 (2005). Sayes CM, Liang F, Hudson JL, Mendez J, Guo WH, Beach JM, Moore VC, Doyle CD, West JL, Billups WE, Ausman KD, Colvin VL; “Functionalization density dependence of SWNT cytotoxicity in vitro”. Tox. Lett. 161(2):135 (2006). Sayes CM, Wahi R, Kurian P, Liu Y, West JL, Ausman KD, Warheit DB, Colvin VL; “Correlating nanoscale titania structure with toxicity: A cytotoxic and inflammatory response study with human dermal fibroblasts and human lung epithelial cells”. Toxicological Sciences, 92 (1): 174-185 (2006). Sayes CM, Reed KL, Warheit DB; “Assessing toxicity of fine and nanoparticles: Comparing in vitro measurements to in vivo pulmonary toxicity profiles”. Tox. Sci. 97(1):163–180 (2007). Sayes CM, Marchione A, Reed KL, Warheit DB; “In vivo pulmonary toxicity study in rats with fullerene water suspensions”. Nano Letters 7(8):2399 (2007). Sayes CM, Reed KL, Abrams L, Subramoney S, Warheit DB; “Validating in vitro nanoparticle toxicity measurements”. Journal of Nanoparticle Research (2008), DOI 10.1007/s11051-008-9471-3. Guo B, Zebda R, Drake SJ, Sayes CM; “Synergistic effect of co-exposure to carbon black and Fe2O3 nanoparticles on oxidative stress in cultured lung epithelial cells”. Particle and Fibre Toxicology 6:4 (2009). Berg JM, Romoser A, Banerjee N, Zebda R, Sayes CM; (2009) “The relationship between pH and Zeta potential of ~30 nm metal oxide nanoparticle suspensions relevant to in vitro toxicological evaluations”. Nanotoxicology, in press. Sayes CM; (2009) Characterization of nanomaterials for toxicity assessments”. Nanomedicine, in press.

C. Research Support Current 1. Texas A&M University Systems, Faculty Startup, “Predicting toxicity of metal oxide nanoparticles: Developing quantitative structure-activity relationships and their generalizations for nanotoxicology research”, (01/01/08-12/31/10) PI. 2. Texas A&M Foundation, research funds from Exponent, Inc. (08/01/08-07/31/09) PI.

Pending 1. NIH NIEHS, “Immunotoxicity of cubic nanocrystals”, (09/01/2009-08/31/2011) PI. 2. Gates Foundation, “Accelerating malaria eradication: Mosquitoes get knocked by nanotechnology”, (01/01/2010-12/31-2010) PI. 3. NSF, “Cellular response to elemental carbon and metal oxide nanomaterials: prediction and mitigation”, (09/01/2009-08/31/2012) co-PI. 4. NIH NIBIB & NIEHS, “Functional and Toxicological Evaluation of Nanomaterial-Enhanced Encapsulated Biosensors”, (12/01/2009-11/30/2014) co-PI. 5. NSF, “Predicting toxicity of metal oxide nanoparticles: Developing quantitative structure-activity relationships and their generalizations for nanotoxicology research”, (09/01/2009-08/31/2012) PI. 6. NSF, “Preparing students for future challenges in both nanoengineering and nanotoxicology research through an undergraduate Research Community-Based Model: Towards a nanoscience degree program at Texas A&M University”, (01/01/2010-12/31/2011) PI.

Completed 1. DuPont Haskell Internal Research Grant; “In vivo validation of in vitro cytotoxicity studies with nanoscale fullerene and titanium dioxide particles in rats” (2006) co-PI. 2. DuPont Titanium Technologies Grant; “Comparative toxicity to algae using nanoparticles versus bulk materials” (2007) PI. 3. DuPont Haskell-Experimental Station Internal Research Grant; “Assessing the pulmonary impacts of various nanoparticle size ranges in rats following inhalation exposures” (2007) co-PI.

PHS 398/2590 (Rev. 09/04) Page 2 Continuation Format Page

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Schwartz, Christian J. Assistant Professor eRA COMMONS USER NAME

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) Iowa State University B.S. 1996 Mechanical Engineering Iowa State University M.S. 1998 Mechanical Engineering Iowa State University Ph.D. 2006 Mechanical Engineering

A. Positions and Honors

Positions and Employment 1998 – 2002 Research Engineer, Applied Physics Division, Southwest Research Institute, San Antonio, TX 2002 – 2003 Senior Research Engineer, Applied Physics Division, Southwest Research Institute 2006 – present Assistant Professor, Department of Mechanical Engineering, Texas A&M University (TAMU) 2009 – present Assistant Professor, Department of Biomedical Engineering, TAMU 2007 – present Faculty Member, Materials Science and Engineering Program, TAMU 2006 – present Faculty Member, Polymer Technology Center, TAMU 2006 – present Faculty Member, Biotechnology Program, TAMU 2006 – present Faculty Member, Institute for Innovation and Design in Engineering, TAMU

Honors 1998, 2006 Iowa State University (ISU) Research Excellence Award 2003 – 2006 Miller Graduate Fellow, ISU 2004 – 2006 National Science Foundation Graduate Research Fellow 2007 Big XII Faculty Fellowship 2009 TAMU Student Led Award for Teaching Excellence (SLATE), 2009 2009 P.L. and C.L. Brittan ’65 Teaching Award for Outstanding Undergraduate Teaching

B. Selected peer-reviewed publications (in chronological order)

(selected from 12 peer-reviewed publications)

1. Schwartz, C.J., and Bahadur, S.: “Observations on the Grinding of Alumina with Variations in Belt Speed, Load, Sample Rotation, and Grinding Fluids,” Wear Processing in Manufacturing, ASTM STP 1362, 1998, 13-28. 2. Schwartz, C.J., and Bahadur, S.: “Studies on the Tribological Behavior and Transfer-Film-Counterface Bond Strength for Polyphenylene Sulfide Filled with Nanoscale Alumina Particles,” Wear, 237 (2000), 261- 273. 3. Schwartz, C.J., and Bahadur, S.: “The Role of Filler Deformability, Filler-Polymer Bonding, and Counterface Material on the Tribological Behavior of Polyphenylene Sulfide (PPS),” Wear, 251(2001), 1532-1540. 4. Schwartz, C.J., and Bahadur, S.: “Development and Testing of a Novel Joint Wear Simulator and Investigation of the Viability of an Elastomeric Polyurethane for Total-Joint Arthroplasty Devices,” Wear, 262(2007), 331-339. 5. Schwartz, C.J., and Bahadur, S.: ”Investigation of Articular Cartilage and Counterface Compliance in Multi- Directional Sliding as in Orthopedic Implants,” Wear, 262(2007), 1315-1320. 6. Schwartz, C.J, Bahadur, S., and Mallapragada, S.: “Effect of Crosslinking and Pt-Zr Quasicrystal Fillers on the Mechanical Properties and Wear Resistance of UHMWPE for Use in Artificial Joints,” Wear, 263(2007), 1072-1080. 7. Schwartz, C.J, and Bahadur, S.:”Investigation of an Approach to Balance Wear Resistance and Mechanical Properties of Crosslinked UHMWPE,” Tribology Letters, 34 (2009), 125-131. 8. Plumlee, K. and Schwartz, C.J.: “Improved Wear Resistance of Orthopaedic UHMWPE by Reinforcement with Zirconium Particles,” Wear, 267(2009), 710-717. 9. Darden, M. and Schwartz, C.J.: “Investigation of Skin Tribology and its Effects on the Tactile Attributes of Polymer Fabrics,” Wear, 267(2009), 1289-1294. 10. Plumlee, K. and Schwartz, C.J.: “Development of Porous UHMWPE Morphologies for Fixation of Gel- Based Materials,” accepted for publication in Journal of Applied Polymer Science, May 2009.

C. Research Support

Ongoing Research Support NSF DUE 0837619 Rajagopal (PI) 9/01/09 – 8/31/11 CCLI: Comprehensive Course Redesign: An Introduction to Mechanics of Materials This study looks at using problem-based learning approaches to improve learning outcomes in an undergraduate Mechanics of Materials course by looking at the mechanical behavior of polymers, composites and other non-traditional engineering materials. Role: Co-PI

Curriculum Vitae January 2009

Contact Information Deborah A. Siegele Associate Professor Department of Biology Texas A&M University 3258 TAMU College Station, TX 77843-3258 979-862-4022 [email protected]

Education 1976 B.A. Biochemistry, Northwestern University, Evanston, IL 1989 Ph.D. Molecular Biology, University of Wisconsin, Madison, WI Advisor: Dr. Carol Gross 1989-92 Post-doctoral Fellow, Harvard Medical School, Boston, MA Dept. of Microbiology & Molecular Genetics, Advisor: Dr. Roberto Kolter

Professional Experience 1992-97 Assistant Professor, Dept. of Biology, Texas A&M University, College Station, TX 1997-present Associate Professor, Dept. of Biology, Texas A&M University, College Station, TX 2003-2006 Graduate Advisor, Dept. of Biology, Texas A&M University, College Station, TX

Professional Societies American Society for Microbiology Genetics Society of America Sigma Xi

Publications

Typas, A., R.J. Nichols, D.A. Siegele, M. Shales, S.R. Collins, B. Lim, H. Braberg, N. Yamamoto, R. Takeuchi, B.L. Wanner, H. Mori, J.S. Weissman, N.J. Krogan, and C.A. Gross (2008) Nature Methods 5:781-787.

Lovingshimer, M.R., D. Siegele, and G.D. Reinhart (2006) Construction of an inducible, pfkA and pfkB deficient strain of Escherichia coli for the expression and purification of phosphofructokinase from bacterial sources. Protein Expr. Purif. 46:475-82.

Siegele, D.A. (2005) Universal stress proteins in Escherichia coli. [commentary] J. Bacteriol. 187:6253-4.

Ganesh, R., D.A. Siegele, and T.R. Ioerger (2003) MOPAC: motif finding by preprocessing and agglomerative clustering from microarrays. Pacific Symp. Biocomputing :41-52.

Champion, M.M., C.S. Campbell, D.A. Siegele, D.H. Russell, and J.C. Hu (2003) Proteome analysis of Escherichia coli K-12 by two-dimensional native-state chromatography and MALDI-MS. Mol. Microbiol. 47: 383-96.

Arnold, C.N., J. McElhanon, A. Lee, R. Leonhart, and D.A. Siegele (2001) Global analysis of Escherichia coli gene expression during the acetate-induced acid tolerance response. J. Bacteriol. 183: 2178-86.

Siegele, D.A., L. Campbell, and J.C. Hu (2000) Green fluorescent protein as a reporter of transcriptional activity in a prokaryotic system. Methods Enzymol. 305: 499-513.

Mao, W. and D.A. Siegele (1998) Genetic analysis of the stationary phase-induced mcb operon promoter in Escherichia coli. Mol. Microbiol. 27:415-24.

Siegele, D.A. and J.C. Hu (1997) Gene expression from plasmids containing the araBAD promoter at subsaturating inducer concentrations represent mixed populations. Proc. Natl. Acad. Sci. USA 94:8168-72.

Siegele, D.A. and L.J. Guynn (1996) Escherichia coli proteins synthesized during recovery from starvation. J. Bacteriol. 178: 6352-6.

Siegele, D.A., K.R. Imlay, and J.A. Imlay (1996) The stationary-phase-exit defect of cydC (surB) mutants is due to the lack of a functional terminal cytochrome oxidase. J. Bacteriol. 178: 6091- 6.

Siegele, D.A. and R. Kolter (1993) Isolation and characterization of an Escherichia coli mutant defective in resulting growth after starvation. Genes and Devel. 7:2629-40.

Kolter, R., D.A. Siegele, and A. Tormo (1993) The stationary-phase of the bacterial life cycle. Annu. Rev. Microbiol. 47:855-874.

Zambrano, M.M., D.A. Siegele, M. Almiron, A. Tormo, and R. Kolter (1993) Microbial competition: Escherichia coli mutants that take over stationary phase cultures. Science 259:1757-60.

Marquardt, J.L., D.A. Siegele, R. Kolter, and C.T. Walsh (1992) Cloning and sequencing of Escherichia coli murZ and purification of its product, a UDP-N-acetylglucosamine enolpyruvyl tranferase. J. Bacteriol. 174: 5748-52.

Dombroski, A.J., W.A. Walter, M.T. Record, Jr., D.A. Siegele, and C.A. Gross (1992) Polypeptides containing highly conserved regions of transcription initiation factor sigma70 exhibit specificity of binding to promoter DNA. Cell 70: 501-12.

Siegele, D.A. and R. Kolter (1992) Life after log. J. Bacteriol. 174:345-8.

Curriculum Vitae Loren C. Skow Page 1

CURRICULUM VITAE Loren C. Skow, Ph.D. November 24, 2005

PRESENT POSITION AND ADDRESS:

Title: Professor Office: Department of Veterinary Integrative Biosciences Phone: (979) 845-3194; FAX: (979) 845-9972;e-mail: [email protected]

PERSONAL DATA:

Date of Birth: September 4, 1946 Place of Birth: Gainesville, Texas

EDUCATION:

Degree/Training Conferring Institution Field Year BS Abilene Christian University Secondary Education 1969 MS Abilene Christian University Biology 1971 PhD Texas A&M University Fisheries Science 1976

PROFESSIONAL EXPERIENCE AND ACADEMIC APPOINTMENTS:

1970 Graduate Instructor in Biology, Abilene Christian University, Abilene, Texas. 1971 Research Assistant in Fisheries Science, Texas A&M University, College Station, Texas. 1972 Rotary International Graduate Fellow in Biology, University of Queensland, Brisbane, Australia. 1973-1976 Research Assistant in Fisheries Science, Texas A&M University, College Station, Texas. 1976-1978 NIH Postdoctoral Trainee in Biomedical Genetics, The Jackson Laboratory, Bar Harbor, Maine. 1978-1979 Research Associate, University of Tennessee Graduate School of Biomedical Science, Oak Ridge, Tennessee. 1979-1981 Research Scientist, Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee. 1981-1985 Senior Staff Fellow, Eukaryotic Gene Structure Section, Laboratory of Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina. 1985-1993 Associate Professor, Department of Veterinary Anatomy, College of Veterinary 1985-1994 Medicine, Texas A&M University, College Station, Texas. 1993-current Professor, Department of Veterinary Anatomy and Public Health, College of Veterinary Medicine, Texas A&M University, College Station, Texas.

Curriculum Vitae Loren C. Skow Page 2 TEACHING PROGRAMS and RESEARCH/SCHOLARLY ACTIVITIES:

Title of Project: Mapping ESTs for Comparative Genomics of the Horse. P.I. B.P. Chowdhary, L.C. Skow and D. Adelson. Funding Source: USDA NRI Molecular Tools and Reagents Total Award: $820,000 Period: 2003-2006

Title of Project: Genomic Mapping of the Horse P.I. E. Bailey (UKy),L.C. Skow(TAMU), J. Mickleson UMn), D. Antczak (Cornell) Funding Source: Morris Animal Foundation Total Award: $100,000 Period: 2002-2005

Title of Project: Haplotypes of the bovine MHC P.I. L.C. Skow, H.M. Scott and C.R. Huber Funding Source: USDA NRI Animal Genomes Total Award: $439,000 Period: 2006-2009

Title of Project: Haplotype structure and polymorphisms of the equine MHC P.I. C. L.Brinkmeyer-Langford and L.C. Skow. Funding Source: USDA NRI Animal Genomes Post-doctoral fellowship Total Award: $125,000 Period: 2007-2009

Publications in Refereed Journals:

Snelling WM, Chiu R, Schein JE, Hobbs M, Abbey CA, Adelson DL, Aerts J, Bennett GL, Bosdet IE, …..Boussaha M, Brauning R, Caetano AR, Costa MM, Crawford AM, Dalrymple BP, Eggen A, Everts-van der Wind A, Floriot S, Gautier M, Gill CA, Green RD, Holt R, Jann O, Jones SJ, Kappes, SM, Keele JW, de Jong PJ, Larkin DM, Lewin HA, McEwan JC, McKay S, Marra MA, Mathewson CA, Matukumalli LK, Moore SS, Murdoch B, Nicholas FW, Osoegawa K, Roy A, Salih H, Schibler L, Schnabel RD, Silveri L, Skow LC, Smith TP, Sonstegard TS, Taylor JF, Tellam R, Van Tassell CP, Williams JL, Womack JE, Wye NH, Yang G, Zhao S; the International Bovine BAC Mapping Consortium. A physical map of the bovine genome. Genome Biol. 8(8):165-178, 2007. Raudsepp T, Gustafson-Seabury A, Durkin K, Wagner ML, Goh G, Seabury CM, Brinkmeyer- Langford C, Lee EJ, Agarwala R, Stallknecht-Rice E, Schäffer AA, Skow LC, Tozaki T, Yasue H Penedo MC, Lyons LA, Khazanehdari KA, Binns MM, MacLeod JN, Distl O, Guérin G, Leeb T, Mickelson JR, Chowdhary BP.A 4,103 marker integrated physical and comparative map of the horse genome.Cytogenet Genome Res. 2008;122(1):28-36. Epub 2008 Oct 14. Wilkerson AJ, Raudsepp T, Graves T, Albracht D, Warren W, Chowdhary BP, Skow LC, Murphy WJ. Gene discovery and comparative analysis of X-degenerate genes from the domestic cat Y bb chromosome.Genomics. 2008 Nov;92(5):329-38. Epub 2008 Aug 28.

David M. Stelly

Current Title: Professor

Appointment: 72.34% teaching, 27.66% research

Physical Address:

New Beasley Lab, Texas A&M University, College Station, Texas 77843-2474

Email Address: [email protected]

Education:

Ph.D., Plant Breeding and Plant Genetics, University of Wisconsin-Madison, 1983 M.Sc., Plant Breeding and Cytogenetics, Iowa State University, 1979 B.Sc., Genetics, University of Wisconsin-Madison, 1975

Recent Teaching Focus:

Cytogenetics (GENE 620; 3 cr. lecture) Histological Principles of Plant Breeding (AGRO 603; 3 cr., lecture & laboratory) Plant molecular and general genetics (AGRO/GENE/MEPS 681) Special Topics - Fluorescence in situ hybridization (FISH) (GENE 685; 2 cr., lecture) Undergraduate research fellows (ad hoc) Undergraduate/graduate student research problems (ad hoc) Major advisor for 3 M.S. and 10 Ph.D. students

Research Focus:

Our research has two thematic foci. ¨ Agricultural and commodity focus: cotton -- a crop of immense importance to Texas, USA and world. ¨ Scientific and disciplinary themes: reproductive biology, cytogenetics, genomics and germplasm introgression.

In addition, we also work collaboratively on the molecular cytogenetics, reproductive genetics, and integrative genomics of other important species, including sorghum, maize, arabidopsis, and loblolly pine.

Research resource development: ¨ Laboratory for Plant Molecular Cytogenetics, a satellite component of the Institute for Plant Genomics & Biotechnology. ¨ Cotton Cytogenetics Collection, for which it develops, curates and distributes cytogenetic stocks of Gossypium hirsutum (L.). ¨ DNA Resources for Cotton Genomics World-wide: ¨ Chromosome substitutions hybrids: DNAs from these cytogenetics stocks enable chromosomal identification of individual markers and linkage groups. ¨ Radiation Hybrids: We have developed similar DNA resources for physical mapping, also for distribution, based on wide-cross whole-genome radiation hybrids (WWRHs).

Professional Accomplishments (limit to bullet statements):

¨ Development of improved stain-clearing methods that aid visual and video plant reproductive cytology examinations. ¨ Development of new chromosome manipulation systems, the "Monosome Walk" and "TTT Shuffle". ¨ Continuing development of the Cotton Cytogenetics Collection. ¨ Development and release of interspecific chromosome substitution lines. ¨ Multiple advances in plant molecular cytogenetics to meiotic and mitotic chromatin. ¨ Development of several key scientific meetings and workshops, including the first international meeting on apomixis (1995). ¨ First elected chair of the International Cotton Genome Initiative (http://icgi.tamu.edu)

Recent Publications (limit to 10 most recent):

Refereed journal publications – 75, Book chapters – 3, Edited – 1, Meeting presentations (abstracts) - 226

¨ Gao, W., Z. J. Chen, J. Z. Yu, D. Raska, R. J. Kohel, J. E. Womack, and D. M. Stelly. 2004. Wide-cross whole- genome radiation hybrid (WWRH) mapping of cotton (Gossypium hirsutum L.). Genetics (in press). ¨ Mei, M., N. H. Syed, W. Gao, P. M. Thaxton, C. W. Smith, D. M. Stelly, and Z. J. Chen. 2004. Genetic mapping and QTL analysis of fiber-related traits in cotton (Gossypium). Theor Appl Genet. 108:280-91. ¨ Kim, J-S, K.L. Childs, M.N. Islam-Faridi, M.A. Menz, R.R. Klein, H.J. Price, J.E. Mullet and D. M. Stelly. 2002. Integrated karyotyping in sorghum by in situ hybridization of landed BACs. Genome 45:402-412. ¨ Islam-Faridi M. N., K.L. Childs, P.E. Klein, G. Hodnett, M.A. Menz, R.R. Klein, W.L. Rooney, J.E. Mullet, D.M. Stelly and H. J. Price 2002. Towards an integrated map for sorghum: A molecular cytogenetic map of chromosome 1. Genetics 161:345-353. ¨ Kohel, R.J., D.M. Stelly and J. Yu. 2002. Tests of six cotton (Gossypium hirsutum L.) mutants for association with aneuploids. J. Heredity 93:130-132. ¨ Karaca, M., S. Saha, J.N. Jenkins, A. Zipf, R. Kohel and D.M. Stelly. 2002. Simple sequence repeat (SSR) markers linked to the Ligon Lintless (Li1) mutant in cotton. J. Hered. 93:221-224. ¨ Tao Q-Z, Y-L Chang, J. Wang, H. Chen, C. Schuering, M.N. Islam-Faridi, B. Wang, D.M. Stelly and H-B. Zhang. 2001. Bacterial artificial chromosome-based physical map of the rice genome constructed by restriction fingerprint analysis. Genetics 158:1711-1724. ¨ De Donato, M., D.S. Gallagher Jr., S.K. Davis, D.M. Stelly and J.F. Taylor. 2001. The assignment of PRKC1 to bovine chromosome 1q34àq36 by FISH suggests a new assignment to human chromosome 3. Cytogenetics and Cell Genetics 95:79-81. ¨ Hanson, R. E., L. E. Jackson, M. S. Zwick, C. F. Crane, M. N. Islam-Faridi, T. D. McKnight, J. F. Wendel, D. M. Stelly, and H. J. Price. 2000. The chromosomal distribution of a copia-like retrotransposon in cotton (Gossypium hirsutum L.). Chrom. Res. 8:73-76. ¨ Zwick, M. S., M. N. Islam-Faridi, H. B. Zhang, G.L. Hodnett, M. Gomez, J.S. Kim, H. J. Price and D. M. Stelly. 2000. Distribution and sequence analysis of the centromere-associated repetitive element CEN38 of Sorghum bicolor (Poaceae). Amer. J. Botany. 87:1757-1764. ¨ Liu S., S. Saha, D. Stelly, B. Burr and R.G.Cantrell. 2000. Chromosomal assignment of microsatellite loci in cotton. J. Heredity. 91:326-332.

Professional Memberships, Leadership Roles and Honors:

¨ Crop Science Society of America -- member ¨ Plant & Animal Genome Conference -- annual workshop organizer ¨ International Cotton Genome Initiative (http://icgi.tamu.edu) ¨ First International Symposium on Apomixis -- organizer ¨ Cotton Genetics Research Award 1995 ¨ Various editorial positions: Chromosome Research, Korea Genetics, Crop Science, Genome, J. Heredity, Euphytica ¨ University Council of Principle Investigators (multiple terms) ¨ Director, TAMU Laboratory for Plant Molecular Cytogenetics

Program Director/Principal Investigator (Last, First, Middle): Zurakowski, Ryan

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES. NAME: POSITION TITLE: Sturino, Joseph M. Assistant Professor eRA COMMONS USER NAME JMSTURINO EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as INSTITUTIONnursing, and AND include LOCATION postdoctoral training.) DEGREE YEAR(s) FIELD OF STUDY University of Wisconsin-Madison Honors-B.S. 1996 Bacteriology University of Wisconsin-Madison (UW) M.S. 2000 Bacteriology North Carolina State University (NCSU) Ph.D. 2003 Functional Genomics

A. Positions and Honors.

Employment 2002 National Institute of Health Biotechnology Training Program Internist, Syngenta Biotechnology Inc. (Durham, NC) 2002 – 2006 Chr. Hansen Inc. Genomics and Strain Development Department. Research Scientist (Milwaukee, WI & Copenhagen, Denmark) 2007 – Present Texas A&M University, Nutrition & Food Science Department, Assistant Professor

Positions and Synergistic Activities 2002 Sigma Xi Honor Society Executive Council, Elected Graduate Student Representative 2004 – Present Ad hoc Reviewer: Antimicrobial Agents and Chemotherapy, Applied and Environmental Microbiology, Letters in Applied Microbiology, Journal of Bacteriology, Journal of Applied Microbiology, Microbiology (UK), International Dairy Journal, Journal of Biotech Research, Journal of Dairy Science, Journal of Molecular Microbiology and Biotechnology 2007 Canadian Institutes of Health Research (CIHR), Innovation and Industry Programs Branch, External Grant Application Reviewer 2008 Natural Sciences and Engineering Research Council of Canada (NSERC), Quality Foods and Novel Bioproducts Strategic Project Grants, External Grant Application Reviewer 2008 – 2010 Applied and Environmental Microbiology, Editorial Board Member 2008 – Present United States Department of Energy Joint Genome Institute/Midwest Center for Structural Genomics/Lactic Acid Bacteria Genomics Consortium Structural Genomics Initiative 2008 – Present Chairperson, Genetics Graduate Student Recruiting Committee. Bolstering student outreach efforts to successfully attract high-caliber applicants from historically underrepresented minority groups. 2009 INSPIRE Mobility in Science Engineering and Technology Postdoctoral Fellowship, Remote Expert Assessor, Micro/Macrobiology Section, Irish Research Council for Science, Engineering and Technology (IRCSET)-Marie Curie International 2009 EMPOWER: Government of Ireland Postdoctoral Fellowships in Science, Engineering and Technology, On-site Panel Member, Micro/Macrobiology Section, IRCSET (Ireland) 2009 Session Moderator, Institute of Food Technologists Annual Meeting (Dairy Division): The Science and Economics Behind Sustainable Dairy Processing. Anaheim, CA; June 6-9.

Honors and Awards: 1993 A. J. Riker Academic Scholarship (UW-Madison) 1995 Senior Honors Thesis Fellowship (UW-Madison) 2000 National Institute of Health Biotechnology Training Program Fellowship (NCSU) 2000 National Science Foundation Research Ethics Fellowship (NCSU) PHS 398/2590 (Rev. 11/07) Page Biographical Sketch Format Page Program Director/Principal Investigator (Last, First, Middle): Zurakowski, Ryan 2002 Speaker Travel Grant, FEMS Seventh Symposium on Lactic Acid Bacteria 2002 Speaker Travel Grant, ASM Sixth Conference on Streptococcal Genetics 2002 Speaker Travel Grant, Plasmid Biology 2002 Inducted into the Sigma Xi Scientific Research Honor Society 2002 Inducted into the Phi Tau Sigma Food Science Honor Society 2003 NCSU Microbiology Dept. Sole Nominee for Keller Award (Best Dissertation) 2002 – 2004 Chr. Hansen Innovation Excellence Award

B. Peer-reviewed publications or manuscripts in press (Selected)

[1] Sturino, J. M., and Klaenhammer, T. R. 2002. Antisense RNA expression targeted against Streptococcus thermophilus bacteriophages. Appl. Environ. Microbiol. 68:588-595. [2] Sturino, J. M., and Klaenhammer, T. R. 2004. Antisense RNA targeting primase interferes with phage replication in Streptococcus thermophilus. Appl. Environ. Microbiol. 70:1735-1743. [3] Sturino, J. M., and Klaenhammer, T. R. 2005. Bacteriophage defense systems and strategies for lactic acid bacteria. In A. I. Laskin, J. W. Bennett, and G. M. Gadd (eds.), Advances in Applied Microbiology vol. 56. Academic Press, San Diego, CA. [4] Sturino, J. M., and Klaenhammer, T. R. 2006. Engineered bacteriophage defense systems in bioprocessing. Nature Microbiol. Rev. 4:395-404. [5] Sturino, J. M., and Klaenhammer, T. R. 2007. Inhibition of phage genome replication through the expression of transdominant mutant primase proteins in S. thermophilus. Microbiol. 153:3295-302. [6] Zorych, I., Sturino, J. M., Chang, Y.Y., Mallick, B. and Carroll, R. 2009. Statistical Methods for Biolog Phenotype Microarrays. Bioinformatics (Submitted)

Patents and Patent Applications (Selected) [1] Sturino, J. M., and Klaenhammer, T. R. (WO Patent 2002/16550; US Patent 2004/6686192). Antisense RNA expression strategies effective against Streptococcus thermophilus phages. [2] Houlberg, U., Herbsleb, P., and Sturino, J. M. (WO/US Applications 2005/068982; 2006/10586325). Method & system for colorimetric determination of a chemical or physical property of media. [3] Sturino, J. M. (WO Application 2006/029632; US Application 2007/0248573). Chimeric phage-derived particles, methods for their production and use. PCT/DK2005/000587.

C. Active Extramural Funding:

[1] TAES 405591 Sponsor: Industry Grant (Redacted) Title: Novel applications for smectite clay Role: Principal Investigator (PI) Award: $73,000 (11/01/2008 to 01/15/2010) Overlap: No overlap with current proposal [2] CA90301 Sponsor: NIH/NCI Title: Nutrition, Biostatistics and Bioinformatics Role: Co-investigator (Dr. Ray Carroll, PI) Award: $2,700,000 (07/01/2006 to 06/30/2011) http://www.stat.tamu.edu/train/ Overlap: No overlap with current proposal [3] RF 0800092 Sponsor: Industry Grant (Redacted) Title: Dietary Fibers as Potential Anti-Inflammatory Agents Role: Co-Investigator (Dr. J. Lupton, PI) Award: $148,000 (10/12/2007 to 09/30/2009) Overlap: No overlap with current proposal

PHS 398/2590 (Rev. 11/07) Page Continuation Format Page

Principal Investigator/Program Director (Last, First, Middle):

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Terry L. Thomas Professor of Biology eRA COMMONS USER NAME Director, Laboratory for Functional Genomics TLTHOMAS EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) University of Georgia, Athens, GA B.S. 1972 Zoology/Chemistry University of Georgia, Athens, GA Ph.D 1975 Molecular Genetics/Zoology California Institute of Technology Postdoctoral 1975-1980 Molecular Biology Pasadena, California Fellow

A. Positions and Honors

Research and Professional Experience

1972-1975 Graduate Research Fellow, Department of Zoology, University of Georgia, Athens, GA 1975-1980 Research Fellow, Division of Biology, California Institute of Technology, Pasadena, CA 1980-1982 Senior Research Fellow, Division of Biology, California Institute of Technology, Pasadena, CA 1983-1988 Assistant Professor, Department of Biology, Texas A&M University, College Station, TX 1988-1992 Associate Professor, Department of Biology, Texas A&M University, College Station, TX 1992-1994 Professor and Interim Head, Department of Biology, Texas A&M University, College Station, TX 1994-2002 Professor and Head, Department of Biology, Texas A&M University, College Station, TX 1999-now Director, Laboratory for Functional Genomics, Texas A&M University, College Station,TX 2000-2004 Director, Genomics and Bioinformatics Core, NIH Center for Environmental and Rural Health, Texas A&M University, College Station, TX 2002-now Professor, Department of Biology, Texas A&M University, College Station, TX

Honors

1972 Merck Chemistry Prize, Department of Chemistry, University of Georgia 1972 Phi Beta Kappa, University of Georgia, 1972 summa cum laude, University of Georgia 1972-1975 Graduate Research Fellow, University of Georgia 1975-1978 NIH/NRSA Fellowship, California Institute of Technology 1978-1980 American Cancer Society Lievere Fellowship, California Institute of Technology

PHS 398/2590 (Rev. 09/04) Page Biographical Sketch Format Page Principal Investigator/Program Director (Last, First, Middle):

B. Selected publications (of 86)

Bailey, M.J., Beremand, P.D., Hammer, R., Bell-Pedersen, D., Thomas, T.L. and Cassone, V.M. (2003) Transcriptional profiling of the chick pineal gland, a photoreceptive circadian oscillator and pacemaker. Molecular Endocrinology 17, 2084-2095 Mu, X., Beremand, P.D., Zhao, S., Pershad, R., Sun, H., Scarpa, A., Liang, S., Thomas, T.L., Klein, W.H. 2003. Discrete gene sets depend on POU transcription factor Brn3b/Brn-3.2/POU4f2 for their expression in the mouse embryonic retina. Development 131, 1197-1210. Bailey, M.J., Beremand, P.D., Hammer, R., Reidel, E., Thomas, T.L. and Cassone,V.M. 2004. Transcriptional profiling of circadian patterns of mRNA expression in the chick retina. J. Biol. Chem. 279, 52247-52254. Liang, S., Zhao, S., Mu., X., Thomas, T. L. and Klein, W.H. 2004. Novel retinal genes discovered by mining the mouse embryonic RetinalExpress database. Molecular Vision, 10, 773-786. Ebbole, D.J., Yuan, J., Thon, M., Pan, H., Bhatterai, E., Thomas, T. and Dean, R. 2004. Gene discovery and gene expression in the rice blast fungus, Magnaporthe grisea: Analysis of expressed sequence tags. Molecular Plant-Microbe Interactions. 17, 1337-1347. Chung, H.J., Fu, H. Y. and Thomas, T.L. 2005. ABA inducible nuclear proteins bind to bipartite promoter elements required for ABA response and embryo regulated expression of the carrot Dc3 gene. Planta 220, 424-433. Mu, X., Fu,X., Sun, H., Beremand, P.D., Thomas, T.L., and Klein, W.H. 2005. A Gene Network Downstream Of Transcription Factor Math5 Regulates Retinal Progenitor Cell Competence And Ganglion Cell Fate. Developmental Biology 280, 467-481. Holtman C.K., Chen, Y, Sandoval, P., Gonzales, A., Nalty, M.S., Thomas, T.L., Youderian, P., and Golden, SS. 2005. High-throughput functional analysis of the Synechococcus elongatus PCC 7942 genome. DNA Research 12, 103-115. Menger, G.J., Lu, K., Thomas, T.L., Cassone, V.M., Earnest, D.J. 2005. Circadian profiling of the transcriptome on immortalized rat SCN cells. Physiological Genomics 21, 370 - 381. Bell-Pedersen, D., Cassone, V.M., Earnest, D.J., Golden, S.S., Hardin, P.E., Thomas, T.L., and Zoran, M.J. 2005. The regulation of circadian rhythmicity by multiple oscillators: lessons from diverse organisms. Nature Reviews Genetics 6, 544-556. Finkelstein, R., Gampala, S., Lynch, T., Thomas, T. and Rock, C. 2005. Redundant and distinct functions of the ABA response loci ABA-INSENSITIVE(ABI)5 and ABRE-BINDING FACTOR(ABF)3. Plant Molecular Biology 59, 253-267. Gray, C.A., Abbery, C.A., Beremand, P.D., Choi, Y., Farmer, J.L., Adelson, D.L., Thomas, T.L., Bazer, F.W., Spencer, T.E. 2006. Transcriptional profiling of endometrial responses to early pregnancy in sheep. Biology of Reproduction 74,383-394. Menger, G., Allen, G., Neuendorff, N., Nahm, S.-S., Thomas, T., Cassone, V., Earnest, D. 2007. Circadian Profiling of the Transcriptome in NIH/3T3 Fibroblasts: Comparison with Rhythmic Gene Expression in SCN2.2 Cells and the Rat SCN. Physiological Genomics, 29, 280-289. Roux, C., Rolan, H., Santos, R.,Beremand, P.,Thomas, T., Adams, L., Tsolis, R. 2007. Brucella requires a functional Type IV secretion system to elicit innate immune responses in mice. Cellular Microbiology, 9, 1851-1869. Mu, X., Fu, X., Beremand, P.D., Thomas, T.L. and Klein, W.H. 2008 Gene regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2. Proc. Natl. Acad. Sci., 105, 6942-6947. Karaganis, S.P., Kumar, V., Beremand, P.D., Bailey, M.J., Thomas, T.L. and Cassone, V.M. 2008. Circadian genomics of the chick pineal gland in vitro. BMC Genomics 9, 206-223.

PHS 398/2590 (Rev. 09/04) Page Continuation Format Page BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Evelyn Tiffany-Castiglioni Professor & Head, Dept. Vet. Integrat. Biosci. eRA COMMONS USER NAME Assoc. Dean for Undergraduate Education ecastiglioni EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) University of Texas-El Paso B.S. 1975 Biology University of Texas-Galveston Ph.D. 1979 Hum. Genet. & Cell Biol. University of California at Los Angeles Postdoc 1980-1982 Develop. Neurobiol.

Please refer to the application instructions in order to complete sections A, B, and C of the Biographical Sketch.

A. Positions and Honors

Positions and Employment: 1982-1987 Assistant Professor, Texas A&M University 1987-1994 Associate Professor, Texas A&M University 1989-1990 Visiting Associate, Professor University of Texas Health Science Center, San Antonio 1990-present Faculty of Neuroscience and Faculty of Toxicology, Texas A&M University 1994-present Professor, Texas A&M University 1996-1998 Asst. Dean for Undergraduate Education, Texas A&M University 1998-present Assoc. Dean for Undergraduate Education, Texas A&M University 1998-1999 Interim Department Head, Texas A&M University, Vet. Anatomy & Public Health 1999-present Department Head, Texas A&M University, Vet. Integrative Biosciences (dept. renamed 2004)

Other Experience and Professional Memberships: Editorial Board of International Journal of Developmental Neuroscience, 2000-present Associate Editor, Neurotoxicology, 2004-present NIOSH SOH Study Section (2003-2007); NSF Graduate Fellowships Review Panel 2000-2002, 2005 Society of Toxicology 42nd Annual Meeting, Invited chair, Continuing Education Course in “Basic Neurotoxicology” Baltimore, MD, March 20-25, 2004 5th International Conference on Early Toxicity Screening: Strategies and Approaches for Toxicity Screening in Drug Discovery and Development, Invited speaker, San Diego, CA, February 21-23, 2005 Society of Toxicology 43nd Annual Meeting, Invited speaker, symposium on “Neurotoxicity of Organophosphates & Carbamates,” New Orleans, LA, March 20-25, 2005 10th Meeting of the International Neurotoxicology Association, Invited chair, symposium on “In Vitro Models and Biosensors for Detecting Neurotoxicity," Porvoo, Finland, June 26-July 1, 2005 International Society for Neurochemistry-European Society for Neurochem Congress, Invited chair, colloquium on “Astrocytes in Neurodegenerative Disease Processes,” Innsbruck, Austria, August 21-26, 2005 TestSmart Developmental Neurotoxicity Testing meeting, sponsored by Center for Alternatives to Animal Testing (CAAT), Johns Hopkins University, Invited plenary speaker, Washington, DC, March 13-15, 2006

B. Selected peer-reviewed publications (from 76 peer-reviewed publications and 12 book chapters) Hong, M.S., S.J. Hong, R. Barhoumi, R.C. Burghardt, K.C. Donnelly, J.R. Wild, V. Venkatraj, E. Tiffany- Castiglioni. 2003. Neurotoxicity induced in differentiated SK-N-SH-SY5Y human neuroblastoma cells by organophosphorus compounds. Toxicol. App. Pharm. 186:110-118. Qian, Y., E. Tiffany-Castiglioni. 2003. Lead-induced endoplasmic reticulum (ER) stress responses in the nervous system. Neurochemical Res. 28:153-162. Tang, Y.K., K.C. Donnelly, M.G. Mumtaz, E. Tiffany-Castiglioni. 2003. Neurotoxicity of polycyclic aromatic hydrocarbons and simple chemical mixtures. J. Tox. Env. Health 66:919-940. Cho, T.M., E. Tiffany-Castiglioni. 2004. Neurofilament 200 as an indicator of differences between mipafox and paraoxon sensitivity in SY5Y neuroblastoma cells. J. Tox. Env. Health, 67:987-1000. Donnelly, K.C., R. Lingenfelter, L. Cizmas, M.H. Falahatpisheh, Y. Qian, Y. Tang, S. Garcia, K. Ramos, E. Tiffany-Castiglioni, M.G. Mumtaz. 2004. Toxicity assessment of complex mixtures remains a goal. Env. Toxicol. Pharm. 18:135–141. Tiffany-Castiglioni, E., Y. Qian. 2004. Astroglia and lead neurotoxicity. In: The Role of Glia in Neurotoxicity, 2nd Ed. M. Aschner and L.G. Costa, eds. CRC Press, Boca Raton. pp. 417-438. Qian, Y., E. Tiffany-Castiglioni. 2005. GRP78 compartmentalized redistribution in Pb-treated glia: role of GRP78 in lead-induced oxidative stress. Neurotoxicology 26:267-75. Qian, Y., Y. Zheng, L. Abraham, K. S. Ramos, E. Tiffany-Castiglioni. 2005. Differential profiles of copper- induced ROS generation in human neuroblastoma and astrocytoma cells. Mol. Brain Res. 134:323-332. Qian, Y., Y. Zheng, K. S. Ramos, E. Tiffany-Castiglioni. 2005. The involvement of copper transporter in lead- induced oxidative stress in astroglia. Neurochemical Research 30:429-438. Tiffany-Castiglioni, E., J.S. Venkatraj, Y. Qian. 2005. Genetic polymorphisms and mechanisms of neurotoxicity: overview. Neurotoxicology 26:641-649. Harry, G. J., E. Tiffany-Castiglioni. 2005. Evaluation of neurotoxic potential by use of in vitro systems. Expert Opin. Drug Metab. Toxicol. 1(4):1-13. Tiffany-Castiglioni, E., Qian, Y. 2005, Chapter 26 Astroglia and Lead Neurotoxicity. In: The Role of Glia in Neurotoxicity, Second Edition. M. Aschner, L. G. Costa (eds), CRC Press, Boca Raton, FL, pp. 417-437. Yang, W., E. Tiffany-Castiglioni. 2005. The bipyridyl herbicide paraquat produces oxidative stress-mediated toxicity in human neuroblastoma SH-SY5Y cells: relevance to the dopaminergic pathogenesis. J.Tox. Env. Health A 68, 1939-1961. Cho, T.M., J. R. Wild, K.C. Donnelly, E. Tiffany-Castiglioni. 2006. Remediation of organophosphorus neurotoxicity in SY5Y neuroblastoma cells by organophosphorus hydrolase (OPH). J. Tox. Env. Health A 69, 1413-1429. Tiffany-Castiglioni, E., J.S. Venkatraj, Y. Qian, J. R. Wild. 2006. In vitro models for testing organophosphate- induced neurotoxicity and remediation. In: Toxicology of Organophosphate & Carbamate Pesticides, Ramesh C. Gupta. Elsevier, Amsterdam. pp. 315-337. Tiffany-Castiglioni, E., Hong, S., Qian, Y., Tang, Y., Donnelly, K.C. 2006. COMMENTARY: In vitro models for assessing neurotoxicity of mixtures. Neurotoxicology 27: 835-839. Qian, Y., J.S. Venkatraj, R. Barhoumi, R. Pal, A. Datta, J.R. Wild, E. Tiffany-Castiglioni. 2007. Comparative non-cholinergic neurotoxic effects of paraoxon and diisopropyl fluorophosphate (DFP) on human neuroblastoma and astrocytoma cell lines. Toxicol. App. Pharm. 219:162-171. Ramos, K.S., H. Falahatpisheh, A. Nanez, Y. Qian, E. Tiffany-Castiglioni, D. Montoya-Durango. Activation profiles of HSPA5 during the glomerular mesangial stress response to chemical injury. Cell Stress and Chaperones 12:209-218, 2007. Barhoumi, R., R.C. Burghardt, Y. Qian, E. Tiffany-Castiglioni. Effects of propofol on intracellular Ca2+ homeostasis in human astrocytoma cells. Brain Research 1145:11-18, 2007. White, L.D., D.A. Cory-Slechta, M.E. Gilbert, E. Tiffany-Castiglioni, N.H. Zawia, M. Virgolini, A. Rossi-George, S.M. Lasley, Y. Qian, M.R. Basha. 2007. New and evolving concepts in the neurotoxicology of lead. Toxicol. App. Pharm. 225:1-27. Yang, W., E. Tiffany-Castiglioni. 2007. The bipyridyl herbicide paraquat induces proteasome dysfunction in human neuroblastoma SH-SY5Y cells. J.Tox. Env. Health A 70:1849-1857. Qian, Y., Y. Zheng, D. Weber, E. Tiffany-Castiglioni. 2007. A 78-kDa glucose-regulated protein is involved in the decrease of interleukin-6 secretion by lead treatment from astrocytes. Am. J. Physiol. [Cell Physiol.] 293:897-905. Yang, W. and E. Tiffany-Castiglioni. 2008. Paraquat-induced apoptosis in human neuroblastoma SH-SY5Y cells: involvement of p53 and mitochondria. J Toxicol Environ Health A 71(4): 289-99. Kern R.J., M.E. Wales, E. Tiffany-Castiglioni, J. R. Wild. 2009. Protection of acetylcholinesterase from organophosphates: kinetic insight into bioscavengers. In: Handbook of Toxicology of Chemical Warfare Agents. Ramesh Gupta, ed. Elsevier, San Diego, CA.

Books Tiffany-Castiglioni, E., ed. 2004. In Vitro Toxicology: Principles and Challenges. Humana Press. BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE

Victor M. Ugaz Assistant Professor, Chemical Engineering

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) University of Texas, Austin, TX B.S. 1991 Aerospace Engineering University of Texas, Austin, TX M.S 1994 Aerospace Engineering Northwestern University, Evanston, IL Ph.D. 1999 Chemical Engineering University of Michigan, Ann Arbor, MI Postdoc 1999-2002 Chemical Engineering

A. Positions and Honors

Professional Experience 1990–1991 Undergraduate Research Assistant, The University of Texas at Austin 1990 Engineering Summer Intern, Hercules Incorporated. 1992-1993 Teaching Assistant, The University of Texas at Austin. 1995-1998 Teaching Assistant, Northwestern University. 1997 Teaching Assistant Fellow, Northwestern University. 1999–2002 Postdoctoral Research Fellow, University of Michigan. 2003–2008 Assistant Professor, Department of Chemical Engineering, Texas A&M University 2008–present Associate Professor, Department of Chemical Engineering, Texas A&M University

Honors 1990 Hercules Engineering Scholarship, The University of Texas at Austin. 1994 McCormick/NSF Minority Graduate Fellowship, Northwestern University. 1994 National Science Foundation Mentoring Assistantship, Northwestern University. 1994 National Science Foundation Minority Graduate Fellowship, Northwestern University. 1996 George Thodos Teaching Assistant Award, Northwestern University. 1997 Dissertation Year Graham Fellowship, Northwestern University. 1998 Finalist, Frank J. Padden, Jr. Award, American Physical Society. 2005 TEES Select Young Faculty Award, Texas A&M University. 2007 George Armistead, Jr. ’23 Faculty Fellow Award, Texas A&M University. 2007 Tenneco Meritorious Teaching Award, Texas A&M University. 2007 Celanese Teaching Excellence Award, Texas A&M University. 2008 Camille Dreyfus Teacher-Scholar Award, Camille and Henry Dreyfus Foundation 2008 Kenneth R. Hall Professorship, Texas A&M University 2009 Deputy Editor, Electrophoresis (2007 ISI Impact Factor = 3.609).

B. Selected Peer-reviewed Publications or Manuscripts In Press

Brahmasandra, S.N., Ugaz, V.M., Burke, D.T., Mastrangelo, C.H., and Burns, M.A. “Electrophoresis in Microfabricated Devices Using Photopolymerized Polyacrylamide Gels and Electrode Defined Sample Injection.” Electrophoresis. 22 (2001): 300-311. Ugaz, V.M., Brahmasandra, S.N., Burke, D.T., and Burns, M.A. “Cross-linked Polyacrylamide Gel Electrophoresis of Single-stranded DNA for Microfabricated Genomic Analysis Systems.” Electrophoresis. 23 (2002): 1450-1459. Ugaz, V.M., Burke, D.T., and Burns, M.A. “Microdevice-based Measurements of Diffusion and Dispersion in Cross-linked and Linear Polyacrylamide DNA Sequencing Gels.” Electrophoresis. 23 (2002): 2777–2787. Krishnan, M., Ugaz, V.M., and Burns, M.A. “PCR in a Rayleigh-Bénard Convection Cell.” Science. 298 (2002): 793. Ugaz, V.M., Lin, R., Srivastava, N., Burke, D.T., and Burns, M.A. “A Versatile Microfabricated Platform for Electrophoresis of Double- and Single-stranded DNA.” Electrophoresis. 24 (2003): 151–157. Razzacki, S.Z., Thwar, P.K., Yang, M., Ugaz, V.M., and Burns, M.A. “Integrated Microsystems for Controlled Drug Delivery.” Advanced Drug Delivery Reviews. 56 (2004): 185-198. Ugaz, V.M., Elms, R.D., Lo, R.C., Shaikh, F.A., and Burns, M.A. “Microfabricated Electrophoresis Systems for DNA Sequencing and Genotyping Applications: Current Technology and Future Directions.” Philosophical Transactions of the Royal Society (Series A: Mathematical, Physical and Engineering Sciences). 362 (2004): 1105-1129. Sudarsan, A.P. and Ugaz, V.M. “Novel Techniques for Rapid Fabrication of Plastic-based Microfluidic Devices.” Analytical Chemistry. 76 (2004): 3229-3235. Ugaz, V.M. and Krishnan M. “Novel Convective Flow Based Approaches for High-Throughput PCR Thermocycling.” Journal of the Association for Laboratory Automation (JALA). 9 (2004): 318-323. Krishnan, M., Agrawal, N., Burns, M.A, and Ugaz, V.M.. “Reactions and Fluidics in Miniaturized Natural Convection Systems.” Analytical Chemistry. 76 (2004): 6254-6265. Sudarsan, A.P., Wang, J., and Ugaz, V.M. “Novel Thermoplastic Elastomer Gels: an Advanced Substrate for Microfluidic Device Construction.” Analytical Chemistry, 77 (2005): 5167-5173. Pal, R., Yang, M., Lin, R., Johnson, B.N., Srivastava, N., Razzacki, S.Z., Chomistek, K.J., Heldsinger, D.C., Haque, R.M., Ugaz, V.M., Thwar, P.K., Chen, Z., Alfano, K., Yim, M.B., Krishnan, M., Fuller, A.O., Larson, R.G., Burke, D.T., and Burns, M.A. “An Integrated Microfluidic Device for Influenza and Other Genetic Analyses.” Lab on a Chip, 5 (2005): 1024-1032. Spitzack, K.D. and Ugaz, V.M. “PCR in Miniaturized Systems: Big Progress in Little Devices.” In Microfluidic Techniques: Reviews and Protocols, Shelley D. Minteer, Editor. Methods in Molecular Biology Series, Humana Press, Inc., Totowa, New Jersey, Volume 321 (2006): Chapter 10. Handal, M.I. and Ugaz, V.M. “DNA Mutation Detection and Analysis Using Miniaturized Microfluidic Systems.” Expert Review of Molecular Diagnostics, 6 (2006): 29-38. Sudarsan, A.P. and Ugaz, V.M. “Fluid Mixing in Spiral Microchannels.” Lab on a Chip, 6 (2006): 74-82. Lo, R.C. and Ugaz, V.M. “Characterizing Separation Performance in Electrophoresis of Single-stranded DNA in Photopolymerized Crosslinked Polyacrylamide Gels.” Electrophoresis, 27 (2006): : 373-386. Chen, X. and Ugaz, V.M. “A Simple and Inexpensive Micro-slab Gel DNA Electrophoresis System with Real Time Fluorescence Detection.” Electrophoresis, 27 (2006): 387-393. Shaikh, F.A. and Ugaz, V.M. “Collection, Focusing, and Metering of DNA in Microchannels Using Addressable Electrode Arrays for Portable Low-power Bioanalysis.” PNAS, 103 (2006): 4825-4830. Highlighted in Analytical Chemistry [Vol. 78 (2006): 3483] and Lab on a Chip [Vol. 6 (2006): 709]. 4th most frequently downloaded Engineering paper from PNAS website, March 2006. Sudarsan, A.P. and Ugaz, V.M. “Multivortex Micromixing.” PNAS, 103 (2006): 7228-7233. Highlighted in Science [Vol. 312 (2006): 1281] and Lab on a Chip [Vol. 6 (2006): 837]. Wang, J. and Ugaz V.M. “Using Rheology to Characterize Microstructure in Photopolymerized Polyacrylamide Gels for DNA Electrophoresis.” Electrophoresis, 27 (2006): 3349-3358. Agrawal, N. and Ugaz, V.M. “A Buoyancy-driven Compact Thermocycler for Rapid PCR.” Clinics in Laboratory Medicine, 27 (2007): 215-223. Agrawal, N. Hassan, Y.A., and Ugaz, V.M. “A Pocket-sized Convective PCR Thermocycler.” Angewandte Chemie International Edition, 46 (2007): 4316-4319. Designated as a “Very Important Paper” by the journal editors. Highlighted in New Scientist [Iss. 2602 (5 May, 2007): 27]. Ugaz, V.M. “PCR in Integrated Microfluidic Systems.” In Integrated Biochips for DNA Analysis, Robin Liu and Abraham P. Lee, Editors. Landes Bioscience, Austin, TX. (2008): Chapter 7. Ugaz, V.M. and Christensen, J.L. “Electrophoresis in Microfluidic Systems.” In Microfluidic Technologies for Miniaturized Analysis Systems, Steffen Hardt and Friedhelm Schönfeld, Editors. Springer-Verlag, Berlin (2007): Chapter 10. Wang, J., Gonzalez, A.D., and Ugaz, V.M. “Tailoring Bulk Transport in Hydrogels Through Control of Polydispersity in the Nanoscale Pore Size Distribution.” Advanced Material s, 20 (2008): 4482-4489. Lo, R.C. and Ugaz, V.M. “Microchip DNA Electrophoresis with Automated Whole-Gel Scanning Detection.” Lab on a Chip, 8 (2008): 2135 – 2145. Huang, J. H., Kim, J., Agrawal, N., Sudarsan, A.P., Maxim, J.E., Jayaraman, A. and Ugaz, V.M. “Rapid Fabrication of Bio-inspired 3-D Microvascular Networks.” Advanced Materials (2009): In press.

Principal Investigator/Program Director (Last, First, Middle): Welsh, C. Jane

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Welsh, C. Jane Professor and Associate Department Head eRA COMMONS USER NAME CJWelsh EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) University of London, U.K. B.Sc. 1976 Microbiology University of London, U.K. Ph.D. 1981 Immunology/Biochem. King’s College Hospital, U.K. Postdoc 1979-1981 Autoimmune liver Dept. of Pathology, Cambridge, U.K. Postdoc 1982-1985 Rheumatoid arthritis Dept. of Pathology, Cambridge, U.K. Postdoc 1985-1989 Multiple sclerosis A. Positions and Honors 1988-1989 Special Supervisor in Pathology, Newnham College, Cambridge University 1989-present Visiting Assistant Professor (1989-1991), Assistant Professor (1991-2000); Associate Professor (2000-2006), Professor (2006-present) Dept. of Veterinary Integrative Biosciences and Dept. of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University 1991-present Member of the Faculty of Neuroscience and Graduate Faculty, Texas A&M University 1998-present Member of the Genetics Faculty, Biotechnology Faculty and Executive Committee of the Faculty of Virology, Texas A&M University 2002-present Executive Committee, Recovery of Function Interdisciplinary Group 2006 -present Associate Department Head, Dept. Veterinary Integrative Biosciences 2007-present Joint appointments in the Dept. Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M Health Science Center and Dept. Psychology, Texas A&M University

Other Experience and Professional Memberships External Reviewer 2001 Alzheimer’s Association Grant Reviewer 2003 Biotechnology and Biological Sciences Research Council, UK NIH Brain Disorders and Clinical Neuroscience Special Emphasis Panel (ZRG1-NMB) 2004 NSF Fellowship Review Panel, NMSS Pilot Grant Reviewer 2005 2008 2009 NSF Fellowship Review Panel 2006 NIH Brain Disorders and Clinical Neuroscience Special Emphasis Panel 2007 2008 2009 American Heart Association Grant Review Panel Editorial Board: Brain, Behavior and Immunity Ad hoc reviewer for: J. Infectious Diseases, Infection and Immunity, J. Virology, American Journal of Physiology: Heart and Circulation, Clinical and Diagnostic Laboratory Immunology, J. Neuroimmunology, Neuroimmunomodulation, Brain Behavior and Immunity, PNAS, Neurotoxicology, Developmental Neuroscience, Neuropathology and Applied Neurobiology, Toxicology in Vitro, J. Neuroscience Memberships: British Society for Immunology, International Society for Neuroimmunology, International Society for NeuroImmunoModulation (Executive Committee 2006-present)

B. Selected peer-reviewed publications (in chronological order). Borrow P, Welsh CJR & Nash AA (1993). Study of the mechanisms by which CD4+ T cells contribute to protection in Theiler’s murine encephalomyelitis. Immunology 80: 502-506. Welsh CJR, Sapatino BV, Rosenbaum B, & Smith R. (1995). Characteristics of cloned cerebrovascular endothelial cells following infection with Theiler's virus. I. Acute infection. J Neuroimmunol. 62: 119-125. PHS 398/2590 (Rev. 09/04) Page Biographical Sketch Format Page Principal Investigator/Program Director (Last, First, Middle): Welsh, C. Jane Sapatino BV, Petrescu A, Rosenbaum B, Peidrahita J, Smith R & Welsh CJR (1995). Characteristics of cloned cerebrovascular endothelial cells following infection with Theiler's virus. II. J Neuroimmunol. 62: 127-135. Walker DH, Popov VL, Crocquet-Valdes PA, Welsh CJR & Feng, H. (1997). Cytokine-induced, nitric oxide-dependent intracellular antirickettsial activity of mouse endothelial cells. J. Lab Invest. 76: 129-138. Borrow P, Welsh CJR, Dean D, Tonks P, Blakemore WF, & Nash AA (1998). Investigation of the role of autoimmune responses to myelin in the pathogenesis of Theiler’s virus-induced demyelinating disease. Immunology 93: 478-484. Campbell T, Meagher MW, Sieve A, Scott B, Storts R, Welsh TH, Welsh CJR (2001). The effects of restraint stress on the neuropathogenesis of Theiler’s virus infection. I. Acute disease. Brain, Behav. Immun. 15: 235-254. Tennakoon D, Smith R, Stewart MD, Spencer TE, Nayak M & Welsh CJR (2001). Ovine interferon-tau modulates the expression of MHC antigens on murine cerebrovascular endothelial cells and inhibits replication of Theiler’s virus. J. Interferon and Cytokine Research, 21: 785-792. Welsh CJR, Bustamante L, Nayak M, Welsh TH, Dean DD & Meagher, M.W. (2004). The effects of restraint stress on the neuropathogenesis of Theiler’s virus infection II: NK cell function and cytokine levels in acute disease. Brain, Behavior and Immunity. 18: 166-174. Johnson RR, Storts R, Welsh TH, Welsh CJR & Meagher MW (2004). Social stress alters the severity of acute Theiler’s virus infection. J. Neuroimmunol.148: 74-85. Mi W, Belyavskyi M, Johnson RR, Sieve AN, Storts R, Meagher MW & Welsh CJR (2004). Alterations in chemokine expression in Theiler’s virus infection and restraint stress. J. Neuroimmunol. 151: 103-115. Sieve AN, Steelman AJ, Young CR, Storts R, Welsh TH, Welsh CJR, & Meagher MW (2004). Chronic restraint stress during early Theiler’s virus infection exacerbates the subsequent demyelinating disease in SJL mice. J. Neuroimmunol., 155: 103-118. Johnson RR, Prentice T, Bridegam P, Young CR, Steelman AJ, Welsh TH, Welsh CJR & Meagher MW (2006). Social stress alters the severity and onset of the chronic phase of Theiler’s virus infection. J. Neuroimmunol. 175: 39-51. Mi W, Prentice TW, Young CR, Johnson RR, Sieve AN, Meagher MW & Welsh CJR (2006) Restraint stress decreases virus-induced pro-inflammatory cytokine expression during acute Theiler’s virus infection. J. Neuroimmunol.178: 59-61 Sieve AN, Steelman AJ, Young CR, Storts R, Welsh TH, Welsh CJR & Meagher MW (2006) Sex dependent effects of chronic restraint stress during early Theiler’s virus infection on the subsequent demyelinating disease in CBA mice. J. Neuroimmunol. 177: 46-62. Villarreal D, Young CR, Storts R, Ting JW & Welsh CJR (2006) A comparison of the neurotropism of Theiler’s virus and poliovirus in CBA mice. Microbial Pathogenesis, 41: 133-143. Mi W, Young CR, Storts R, Steelman A, Meagher MW & Welsh CJR (2006) Stress alters pathogenecity and facilitates systemic dissemination of Theiler’s virus. Microbial Pathogenesis 41: 149-156. Fuller, A, Yahikozawa, H, So EY, Dal Canto M, Koh CS, Welsh CJ & Kim BS (2007) Castration of male C57L/J mice increases susceptibility and estrogen treatment restores resistance to Theiler's virus-induced demyelinating disease. J Neurosci Res. 85: 871-881. Meagher MW, Johnson RR, Young EE, Vichaya EG, Lunt S, Hardin EA, Connor MA & Welsh CJR (2007) Interleukin 6 as a mechanism for the adverse effects of social stress on acute Theiler’s virus infection. Brain Behavior and Immunity 21: 1083-1095. Meagher MW, Johnson RR, Vichaya EG, Young EE, Lunt S & Welsh CJR (2007). Social conflict exacerbates an animal model of multiple sclerosis. Trauma, Violence & Abuse 8, 314-330. Young EE, Prentice TW, Satterlee D, McCullough H, Sieve AN, Johnson RR, Welsh TH, Welsh CJR, & Meagher MW (2008) Glucocorticoid exposure alters the pathogenesis of Theiler's murine encephalomyelitis virus during acute infection. Physiology and Behavior 95: 63-71. Castiglioni JA, Russell MI, Setlow B, Young KA, Welsh, CJR, Li LH, & Steele-Russell, I. (2009). An animal model of hypnotic pain attenuation. Behavioral Brain Research 197:198-204. Steelman AJ, Dean DD, Young CR, Smith R, Prentice TW, Meagher MW & Welsh CJR. (2009) Restraint stress modulates virus specific adaptive immunity during acute Theiler’s virus infection. Brain, Behavior and Immunity 23: 830-843

PHS 398/2590 (Rev. 09/04) Page Continuation Format Page

Principal Investigator/Program Director (Last, First, Middle): Wild, James R.

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE James R. Wild Professor of Biochemistry, Genetics, and eRA COMMONS USER NAME Toxicology

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable)

A. Positions and Honors

Positions and Employment 1981 – present Professor of Genetics, Texas A&M University 1984 – present Professor of Biochemistry & Biophysics, Texas A&M University 1992 – present Master Teacher (College of Agriculture and Life Sciences) 1994 – present Professor of Toxicology, Texas A&M University 1998 Fellow, American Association for the Advancement of Sciences 1999 – present Texas A&M University/Texas AgriLife Faculty Fellow 2004 International Fellow, International Union of Pure and Applied Chemistry 2005 – 2008 Chairman, Faculty of Genetics, Texas A&M University

Texas A&M University System Activities: 1999- 2007 Program Director, “Chemical/Biological Detection and Remediation Program” Disaster Relief and Emergency Medical Services (DREAMS) TATRC, U.S. Army (Six academic co-PIs)

National and International Services Activities: 2001-present Member, Defense Threat Reduction Agency – Science and Technological Advisory Committee, Chemical and Biological Warfare Taskforce 1999-present Member, NATO Working Group – Enzyme-based Decontamination of Chemical Threat Agents

B. Peer-reviewed Publications, last 2 years (in chronological order)

Ramanathan, M., Luckarift, H.R., Sarsenova, A., Wild, J.R., Ramanculov, E.K., Olsen, E.V., Simonian, A.L. (2009) Lysozyme Mediated Formation of Protein-Silica Nano-Composites for Biosensing Applications. Collois and Surface B: Biointerface. (in press).

PHS 398/2590 (Rev. 09/04) Page 1 Biographical Sketch Format Page Principal Investigator/Program Director (Last, First, Middle): Reeves, T., Paliwal, S., Wales, M.E., Wild, J.R., and Simonian, A. (2009) Orientation Specific Positioning of Organophosphorus Hydrolase on Solid Interfaces for Biosensor Applications. Langmuir (in press). Wales, M.E., Kern, R.J., Tiffany-Castiglioni, E., Wild, J.R. (2009) In vitro Protection of Acetylcholinesterase from Inhibition by Organophosphate Neurotoxicants: Kinetic Insight into in vivo Expectations. In Toxicology of Chemical Warface Agent. Ed. R.C. Grupta 69:1041-1051. Wales, M.E., Novikov, B.N. Wild, J.R. (2009) The Structural Divergence and Regulatory Logic in the Evolution of ATCases. Aspartate Transcarbamolyases Ed. Guy Herve. (in press) McDaniel, C.S., McDaniel, J., Wild, J.R., Wales, M.E. (2009) Biocatalytic Paints and Coatings. ACS Symposium Series 1002, Smart Coatings II 12:239-249. Budai, M. Gróf, P., Zimmer, A., Wales, M.E., Wild, J.R., Klebovich, I., Chapela, P., Petrikovics, I. (2009) Physico-chemical Characterization of Stealth Liposomes Encapsulating an Organophosphate Hydrolyzing Enzyme. J.Liposome Res. 23:1-6. Wales, M.E., McDaniel, C.S., Kern, R., Wild, J.R. (2008) Enzyme Technology: Applications for the Decontamination of Organo-phosphorus Agents. United Nations OPCW Proceedings (in press) Pinkerton, T.S., Howard, J.A., Wild, J.R. (2008) Genetically engineered resistance to organophosphate herbicides provides a new scoreable and selectable marker system for transgenic plants. Molecular Breeding 21:27-36. Reeves, T.E., Wales, M.E., Grimsley, J.K., Li, P., Cerasoli, D.M., Wild, J.R. (2008) Balancing the stability and the catalytic specificities or OP hydrolases with enhanced V-agent Activities. Protein Eng. Design. Sel. 21(6):405-12. Ha, Jiyeon, Engler, C.R., Wild, J.R. (2008) Biodegradation of coumaphos, chlorferon, and diethylthiophosphate using bacterial immobilized in Ca-alginate gel beads. Bioresource Technol. DOI: 10.1016/ j.biortech.2008.08.022. Paliwal, S., Wales, M.E., Good, T., Grimsley, J.K., Wild, J.R., Simonian, A.I. (2008) Fluorescence-based sensing of p-nitrophenol and p-nitrophenyl substituent organophosphates. Analytica Chimica Acta. (in press).

C. Research Support

Ongoing Research support (as P.I.):

NIH/NINDS – 5 U01 NS058035-03 (9/06-8/11) NIH – counter act Program Catalytic Bioscavengers with Broad Specificity Against OP Nerve Agents: The objective of this research is to develop new and improved medical countermeasures, based on catalytic bioscavengers, against the high priority OP neurotoxic agents. TAMU role: PI

NSF (3134-03 Auburn University) (10/03-9/08) Nanoparticle-based Biosensor for Direct Detection of Organophosphate Chemical Warfare Agents and Neurotoxic Pesticides. This is a sub-contract agreement with Auburn University to provide enzymes for development of biosensors for OP detection. TAMU. Role: co-PI.

Reactive Surfaces Ltd (/03-12/09) Industrial Sponsored Research Agreement for the Optimization and Scale-up of CWA Degradative Capabilities. Provides funds for development and oversight of scalp-up processes for production of enzymes utilized in RSL’s surface technology . Role: co-PI.

NSF – OISE 0424002 (co-PI) 7/04-09/07) U.S. India Cooperative Research: Organization & Regulation of Organosphosphorus Pesticide Degrading Genes in Soil Bacteria. This is a US-India collaboration studying horizontal transmission of genes in bacteria, using the opd gene, which due to the relatively few members of this gene family, it’s the wide geographic distribution and the uniform association with pesticide use, provides a model system. Role: co-Pi.

PHS 398/2590 (Rev. 09/04) Page 2 Continuation Format Page

BIOGRAPHICAL SKETCH

NAME POSITION TITLE Thomas K. Wood T. Michael O’Connor II Endowed Professor of eRA COMMONS USER NAME Chemical Engineering TKWOOD EDUCATION/TRAINING

INSTITUTION AND LOCATION DEGREE YEAR(s) FIELD OF STUDY (if applicable) University of Kentucky B.S. 1985 chemical engineering North Carolina State University Ph.D. 1991 chemical engineering

A. Positions & Honors Positions 1983, 1984 Summer engineer for Westinghouse Hanford Co. and Exxon Co., USA, Baton Rouge, LA 1985-1986 Process engineer (Corporate Center for Engineering) at Rohm and Haas Co., Bristol, PA 1991 Process engineer (corporate research) at Becton Dickinson & Co., Research Triangle Park, NC 1991-1998 Assistant Professor, earned rank of Associate Prof. (tenure) with 2-yr acceleration toward Full Prof. (1997), Dept. of Chemical & Biochemical Engineering, University of California, Irvine 1998-2003 Associate Professor (tenured), Dept. of Chemical Engineering with a joint appointment in Molecular and Cellular Biology, University of Connecticut 2003 Full Professor, University of Connecticut 2004-2005 Northeast Utilities Endowed Chair in Environmental Engineering Education, University of CT 2005-present T. Michael O’Connor II Endowed Chair and Professor, Departments of Chemical Engineering, Biology, and Civil Engineering, Texas A & M University

Honors American Chemical Society Upstream Symposium Keynote Address (2008) American Institute of Chemical Engineers Bioengineering Plenary Award (2007) T. Michael O’Connor II Endowed Chair (2005) University of Connecticut AAUP Research Excellence Award (2005) University of Connecticut Northeast Utilities Endowed Chair in Environmental Engineering Education (2004) University of Connecticut School of Engineering Outstanding Junior Faculty Award (2000) University of Connecticut Rogers Outstanding Teaching Award in Chemical Engineering (2000) University of CA, Irvine Campuswide Faculty Career Development Award (1996) University of CA, Irvine Dept. of Chemical & Biochemical Engineering Outstanding Professor Award (1996) University of CA, Irvine School of Engineering Outstanding Assistant Professor Award (1994) U.S. Army Research Office Young Investigator Award (1992) National Science Foundation Research Initiation Award (1992) UCI Faculty Research Fellowship Award (1992) North Carolina State University Dean's Distinguished Graduate Fellowship University of Kentucky College of Engineering Outstanding Student Award

Professional Memberships American Society for Microbiology & the American Chemical Society Editorial Board, Applied & Environmental Microbiology, 2003-present; Microbial Biotechnology, 2007-present

B. Selected peer-reviewed publications (150 to date, 5 Faculty of 1000 publications) 34. "Aerobic Degradation of Tetrachloroethylene by Toluene-o-Xylene Monooxygenase of Pseudomonas stutzeri OX1," D. Ryoo, H. Shim, P. Barbieri, and T. K. Wood, Nature Biotechnology 18: 775-778 (2000). 39. "Inhibition of Biofilm Formation and Swarming of Escherichia coli by (5Z)-4-Bromo-5-(Bromomethylene)-3- Butyl-2(5H)-Furanone," D. Ren, J. J. Sims and T. K. Wood, Environmental Microbiology 3:731-736, (2001). 63. “Differential Gene Expression to Investigate E. coli Biofilm Inhibition by Plant Extract Ursolic Acid,” D. Ren, R. Zuo, A. Gonzales, L. Bedzyk, & T. K. Wood, Appl. Environ. Microbiol., 71:4022-4034 (2005).

Principal Investigator: Wood, Thomas K. 69. “Gene Expression in Escherichia coli Biofilms,” D. Ren, L. Bedzyk, R. W. Ye, S. Thomas, and T. K. Wood, Applied Microbiology and Biotechnology 64: 515-524 (2004). 81. "Controlling the Regiospecific Oxidation of Aromatics via Active Site Engineering of Toluene para- Monooxygenase of R. pickettii PKO1," A. Fishman … and T. K. Wood, J. Biol. Chem. 280: 506-514 (2005). 94. “Autoinducer 2 Controls Biofilm Formation in E. coli K12 Through…(MqsR, B3022),” A. F. Gonzalez Barrios, R. Zuo, Y. Hashimoto, L. Yang, W. E. Bentley, and T. K. Wood, J. Bacteriol. 188: 305-316 (2006). 96. "YdgG (TqsA) Controls Biofilm Formation in Escherichia coli K12 Through Autoinducer 2 Transport, M. Herzberg, I. K. Kaye, W. Peti, and T. K. Wood, J. Bacteriol. 188: 587-598 (2006). 109."Temporal Gene-Expression in Escherichia coli K-12 Biofilms," J. Domka, J. Lee, T. Bansal, and T. K. Wood, Environ. Microbiol. 9: 332-346 (2007). 111. “A Stochastic Model of E. coli AI-2 Quorum Signal Circuit…," J. Li, L. Wang, Y. Hashimoto, C.-H. Tsao, T. K. Wood, J. J. Valdez, E. Zafiriou, W. E. Bentley, Nature/EMBO Molecular Systems Biology 2:67 (2006). 113."YcfR (BhsA) Influences Escherichia coli Biofilm Formation Through Stress Response and Surface Hydrophobicity," X.-S. Zhang, R. Garcia Contreras, and T. K. Wood, J. Bacteriol. 189: 3051-3062 (2007). 114. "Enterohemorrhagic E. coli Biofilms Are Inhibited by 7-Hydroxyindole and Stimulated by Isatin," J. Lee, T. Bansal, A. Jayaraman, W. E. Bentley, and T. K. Wood, Appl. Environ. Microbiol., 73: 4100-4109 (2007). 115. "Indole is an inter-species biofilm signal mediated by SdiA," J. Lee, A. Jayaraman, and T. K. Wood, BMC Microbiology 7:42 (2007). 119. “Differential Effects of Epinephrine, Norepihrine, and Indole on E. coli O157:H7 Chemotaxis, Colonization, and Gene Expression,” T. Bansal, D. Englert, J. Lee, M. Hegde, T. K. Wood, and A. Jayaraman, Infect. Immun.,75:4597 (2007). 122. "Metabolic Engineering to Enhance Bacterial Hydrogen Production,” T. Maeda, V. Sanchez-Torres, and T. K. Wood, Microbial. Biotechnol. 1:30-39 (2008). 123."Structure and Function of the E. coli Protein YmgB…," J. Lee, R. Page, R. García-Contreras, J.-M. Palermino, X.-S. Zhang, O. Doshi, T. K. Wood J. Molecular Biology, 373:11-26 (2007). 124. "Pseudomonas aeruginosa PAO1 Virulence Factors and Poplar Tree Response in the Rhizosphere." C. Attila, A. Ueda, S. L. G. Cirllo, J. D. Cirillo, W. Chen, and T. K. Wood, Microb. Biotechnol. 1: 17-29 (2008). 130. “Temporal regulation of enterohemorrhagic Escherichia coli virulence mediated by autoinducer-2,” T. Bansal, … T. K. Wood, and A. Jayaraman, Appl. Microbiol. Biotechnol. 78: 811-819 (2008). 131. "Escherichia coli transcription factor YncC (McbR) regulates colanic acid and biofilm formation by repressing expression of periplasmic protein YbiM (McbA)," X.-S. Zhang, R. Garcia Contreras, and T. K. Wood, Nature ISME Journal 2: 615-631 (2008). 133. "The R1 Conjugative Plasmid Increases Escherichia coli Biofilm Formation through an Envelope Stress Response," X. Yang, Q. Ma, and T. K. Wood, Appl. Environ. Microbiol. 74: 2690-2699 (2008). 137. "Indole cell signaling occurs primarily at low temperatures in Escherichia coli," J. Lee, X.-S. Zhang, M. Hegde, W. E. Bentley, A. Jayaraman, and T. K. Wood, Nature ISME Journal 2:1007-1023 (2008). 139. "Protein Translation and Cell Death: The Role of Rare tRNAs in Biofilm Formation and in Activating Dormant Phage Killer Genes," R. Garcia-Contreras, X.-S. Zhang, Y. Kim and T. K. Wood, PLoS ONE 3: e2394 (2008). 140. "Uracil influences quorum sensing and biofilm formation in Pseudomonas aeruginosa and fluorouracil is an antagonist," A. Ueda, C. Attila, M. Whiteley, and T. K. Wood, Microb. Biotechnol. 2: 62-74 (2009). 141. "Indole and 7-hydroxyindole diminish Pseudomonas aeruginosa virulence," J. Lee, C. Attila, S. L. G. Cirillo, J. D. Cirillo, and T. K. Wood, Microb. Biotechnol. 2: 75-90 (2009). 144. "Toxin-Antitoxin Systems in Escherichia coli Influence Biofilm Formation Through YjgK (TabA) and Fimbriae," Y. Kim, X. Wang, Q. Ma, X.-S. Zhang, and T. K. Wood, J. Bacteriol. 191: 1258-1267 (2009). 145. "Reconfiguring the Quorum-Sensing Regulator SdiA of Escherichia coli to Control Biofilm Formation via Indole and N-Acylhomoserine Lactones," J. Lee, T. Maeda, S. H. Hong, and T. K. Wood, Appl. Environ. Microbiol., 75:1703 (2009). 147. "Control and benefits of CP4-57 prophage excision in Escherichia coli biofilms," X. Wang, Y. Kim, and T. K. Wood, Nature ISME Journal on-line (2009). 150. “Connecting Quorum Sensing, c-di-GMP, Pel Polysaccharide, and Biofilm Formation in Pseudomonas aeruginosa Through Tyrosine Phosphatase TpbA (PA3885),” A. Ueda and T. K. Wood, PLoS Pathogens 5:e1000483 (2009).

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Young, Colin Ruaraidh Adjunct Faculty, Department of Veterinary Integrative Biosciences, College of Veterinary Medicine, Texas A&M eRA COMMONS USER NAME University

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) Kings College (KQC) London, University of London B.Sc. 1974 Microbiology Kings College (KQC) London, University of London Ph.D. 1977 Immunology A. Positions and Honors. Positions and Employment 1977-1978 Postdoctoral Research Fellow in Immunogenetics and Transplantation Immunology, Department of Microbiology and Immunology, University of California at Los Angeles 1978-1980 Lecturer in Immunology, Department of Microbiology, University of Surrey, England 1980-1982 Research Associate in Cellular and Molecular Immunology, Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA 1982-1984 Visiting Scientist in Molecular and Cellular Immunology, Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA 1982-1985 Research Associate in Cellular and Molecular Immunology, Department of Pathology, Division of Immunology, University of Cambridge, England 1985-1989 McAlpine Trust Research Scientist in Cellular and Molecular Immunology, Department of Virology, National Institute for Biological Standards and Control, London, England 1989-1994 Associate Professor of Immunology and Microbiology, Departments of Veterinary Microbiology and Parasitology and Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, Texas, USA 1994-2000 Research Scientist, United States Department of Agriculture, Agricultural Research Service, College Station, Texas, USA 1994-present Adjunct Faculty, Department of Veterinary Integrative Biosciences, College of Veterinary Medicine, Texas A&M University 2000-present Consultant in Infectious Diseases 2002-present Research Scientist, Department of Veterinary Integrative Biosciences 1994-present Visiting Professor, University of Cario, College of Veterinary Medicine, Egypt 1994-present Visiting Professor, Alexandria College of Veterinary Medicine, Alexandria, Egypt 1994-present Visiting Professor, Tanta College of Science, Tanta, Egypt 1994-present Visiting Professor, College of Medicine, Ains Champs University, Cario, Egypt

B. Selected peer-reviewed publications (in chronological order). (Publications selected from 133 peer-reviewed publications) Harvey, R.B., Anderson, R.C., Young, C.R., Hume, M.E., Genovese, K.J., Ziprin, R.L., Farrington, L.A., Nisbet, D.J., and Stanker, L.H (1998) Prevelance of Campylobacter, Salmonella, and Arcobacter species at slaughter in market-age pigs in Texas.. Advances in experimental medicine and biology, 473, 237-241. Anderson, R.C., Stanker, L.H., Young, C.R., Buckley, S.A., Genovese, K.J., Harvey, R.B., DeLoach, J.R., Keith, N.K., and Nisbet, D.J. (1999) Swine Competitive exclusion of Salmonella cholerasuis from porcine gastrointestinal tract. Health and Production, 7(4), 155-160. Young, C.R., Ziprin, R.L., Hume, M.E. and Stanker, L.H. (1999) Dose response and organ invasion of day-of-hatch leghorn chicks by different isolates of Campylobacter jejuni. Avian Diseases, 43, 763-767. Harvey, R.B., Young, C.R., Ziprin, R.L., Hume, M.E., Genovese, K.J., Anderson, R.C., Droleskey, R.E., Stanker, L.H. and Nisbet, D.J (1999) Prevelance of Campylobacter spp isolated from the intestinal tract of pigs raised in an integrated swine production system.. JAVMA, 215, 1601-1604. Dill, K., Stanker, L.H., Young, C.R. (1999) Detection of salmonella in poultry using a silicon chip-based biosensor. Journal of Biochemical & Biophysical Methods. 41:61-7. Muldoon, M.T., Font, I.A., Beier, R.C., Holtzapple, C., Young, C.R., and Stanker, L.H (1999) Development of a Cross- Reactive Monoclonal Antibody to Sulfonamide antibiotics: Evidence for Structural Conformation-Selective Hapten recognition. Food and Agricultural Immunology, 11 (2) 117-34. Filipov, N.M., Thompson, F.N., Stuedemann, J.A., Elsasser, T.H., Kahl, S., Young, C.R., Stanker, L.H., Sharma, R.P., and Smith, C.K. (1999) Increased Responsiveness to Intravenous Lipopolysaccharide (LPS) Challenge in Steers Grazing

Endophyte-Infected Tall Fescue Compared to Steers Grazing Endophyte-Free Tall Fescue. Journal of Endocrinology, 163 (2): 213-20. Young, C.R., Harvey, R., Anderson, R., Nisbet, D., Stanker, L.H. (2000) Enteric colonisation following natural exposure to Campylobacter in pigs. Research in Veterinary Science. 68:75-8. Eicher, S.D., Morrow-Tesch, J.L., Albright, J.L., Young, C.R., and Stanker, L.H. Tail-docking Alters Behaviour and Immunological and Endocrine Measures. Journal of Dairy Science 83, 1456-62. Harvey, R.B., Anderson, R.C., Young, C.R., Hume, M.E., Genovese, K.J., Ziprin, R.L., Farrington, L.A., Stanker, L.H., Nisbet, D.J. (1999) Prevalence of Campylobacter, Salmonella, and Arcobacter species at slaughter in market age pigs. Advances in Experimental Medicine & Biology. 473:237-9,. Young, C.R., Ziprin, R.L., Hume, M.E. Stanker, L.H. (1999) Dose response and organ invasion of day-of-hatch Leghorn chicks by different isolates of Campylobacter jejuni. Avian Diseases. 43:763-7. Ziprin, R.L., Young, C.R., Stanker, L.H., Hume, M.E., Konkel, M.E. (1999) The absence of cecal colonization of chicks by a mutant of Campylobacter jejuni not expressing bacterial fibronectin-binding protein. Avian Diseases. 43:586-9. Filipov, N.M., Thompson, F.N., Stuedemann, J.A., Elsasser, T.H., Kahl, S., Stanker, L.H., Young, C.R., Dawe, D.L., Smith, C.K. (2000) Anti-inflammatory effects of ergotamine in steers. Proceedings of the Society for Experimental Biology & Medicine. 225:136-42. Harvey, R.B., Young, C.R., Anderson, R.C., Droleskey, R.E., Genovese. K.J., Egan, L.F., Nisbet, D.J. (2000) Diminution of Campylobacter colonization in neonatal pigs reared off-sow. Journal of Food Protection. 63:1430-2. Wu, Y.J. Wright, J.T., Young, C.R., Cartwright, A.L. (2000) Inhibition of chicken adipocyte differentiation by in vitro exposure to monoclonal antibodies against embryonic chicken adipocyte plasma membranes. Poultry Science. 79:892- 900. Harvey, R.B., Anderson, R.C., Young, C.R., Swindle, M.M., Genovese, K.J., Hume, M.E., Droleskey, R.E., Farrington, L.A., Ziprin, R.L., Nisbet, D.J. (2001) Effects of feed withdrawal and transport on cecal environment and Campylobacter concentrations in a swine surgical model. Journal of Food Protection. 64:730-3. Kubena, L.F., Bailey, R.H., Byrd, J.A., Young, C.R., Corrier, D.E., Stanker, L.H., Rottinghaust, G.E. (2001) Cecal volatile fatty acids and broiler chick susceptibility to Salmonella typhimurium colonization as affected by aflatoxins and T-2 toxin. Poultry Science. 80(4):411-7. Beier, R.C., Ripley, L.H., Young, C.R., Kaiser, C.M. (2001) Production, characterization, and cross-reactivity studies of monoclonal antibodies against the coccidiostat nicarbazin. Journal of Agricultural & Food Chemistry. 49:4542-52. Ziprin, R.L., Young, C.R., Byrd, J.A., Stanker, L.H., Hume, M.E. Gray, S.A., Kim, B.J., Konkel ,M.E. (2001) Role of Campylobacter jejuni potential virulence genes in cecal colonization. Avian Diseases. 45 :549-57. Kubena, L.F., Byrd, J.A., Young, C.R., Corrier, D.E. (2001) Effects of tannic acid on cecal volatile fatty acids and susceptibility to Salmonella typhimurium colonization in broiler chicks. Poultry Science. 80:1293-8. Ziprin, R.L., Hume. M,E., Young, C.R., Harvey, R.B. (2002) Inoculation of chicks with viable non-colonizing strains of Campylobacter jejuni: evaluation of protection against a colonizing strain. Current Microbiology. 44 :221-3. Ziprin, R.L., Hume, M.E., Young, C.R. and Harvey, R.B. (2002) Cecal colonization of chicks by porcine strains of Campylobacter coli. Avain Diseases 46 (2): 473-477. Sieve, A. N., Steelman, A.J., Young C.R., Storts, R., Welsh, T.H., Welsh, C. J. R., & Meagher, M. W. (2004). Chronic restraint stress during early Theiler’s virus infection exacerbates the subsequent demyelinating disease in SJL mice. J. Neuroimmunol., 155, 103-118. Young, C.R. and Welsh, C. J. (2005) Stress, Health and Disease: A Review. Cell Science Reviews. 2, 132-159. Online http://www.cellscience.com/journal/journalindex.asp. Johnson, R.R., Prentice T., Bridegam, P., Young C.R., Steelman A.J., Welsh, T.H., Welsh, C.J.R. and Meagher, M.W. (2006) Social stress alters the severity and onset of the chronic phase of Theiler’s virus infection. J. Neuroimmunology, 175, 39- 51. Villarreal, D., Young, C.R., Storts, R., Ting, J.W., and Welsh, C.J.R. (2006) A comparison of the neurotropism of Theiler’s virus and poliovirus in CBA mice. Microbial Pathogenesis, 41 149-156. Mi W., Young, C.R., Storts, R., Steelman, A., Meagher, M.W. and Welsh, C.J.R. (2006) Stress alters pathogenecity and facilitates systemic dissemination of Theiler’s virus. Microbial Pathogenesis, 41, 133-143. Mi, W., Prentice T.W., Young, C.R., Johnson, R.R., Sieve, A.N., Meagher, M.W., Welsh, C.J.R. (2006) Restraint stress decreases virus-induced pro-inflammatory cytokine expression during acute Theiler’s virus infection. J. Neuroimmunology, 178: 49-61. Sieve, A. N., Steelman, A.J., Young C.R., Storts, R., Welsh, T.H., Welsh, C. J. R., and Meagher, M. W. (2006) Sex dependent effects of chronic restraint stress during early Theiler’s virus infection on the subsequent demyelinating disease in CBA mice. J. Neuroimmunol. 177, 46-62. Welsh, C.J.R., Steelman, A.J., Mi, W., Young, C.R., Storts, R., Welsh, T.H. and Meagher, M.W. (2009) Neuroimmune interactions in a model of multiple sclerosis. Annals of the New York Academy of Science, 1153, 209-219.

Principal Investigator/Program Director (Last, First, Middle): Young, Ryland

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Ryland Young Sadie Hatfield Professor of Agriculture eRA COMMONS USER NAME NIH eRA Commons ID: ryland EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) California Inst. of Technology, Pasadena, CA 1964-65 Rice University, Houston TX A.B. 1965-68 Biochemistry MIT, Boston, MA 1968-69 Biology (left for military) Univ. of Texas, Dallas, TX Ph.D. 1971-75 Molecularservice) Biology Harvard Medical School, Boston, MA postdoc 1977-78 Molecular Biology

A. Positions and Honors

Positions and Employment 1969; 1971-73 NSF Predoctoral Fellow 1969 - 1971 Officer, U.S. Navy, combat systems, FLECOMPUTPROGCENPAC 1973 - 1975 Graduate Assistant, U.T. Dallas Program in Molecular Biology 1976 - 1978 NIH Postdoctoral Fellow 1978 - 1986 Assist./Assoc. Professor of Medical Biochemistry, Texas A&M University 1987 - now Professor of Biochemistry and Biophysics, Texas A&M University 1987 - now Professor of Biology, Texas A&M University 2003 - 2004 Executive Director of Research and Development, GangaGen Inc. 2006 - now Sadie Hatfield Professor of Agriculture, Texas A&M University

Awards, Honors, Editorial, Review and Advisory Board Appointments 2007 Colloquium Advisory Committee for 2008 ASM General Meeting 2003 elected Fellow of the American Academy for the Advancement of Science 2003 elected Fellow of the American Academy of Microbiology 2002 - now Scientific Advisory Board, GangaGen Corporation 2002 Texas A&M University Association of Former Students Distinguished Achievement in Research Award 2000 TAES Faculty Fellow 2000 Chairman , Division M, ASM 1999 - 2004 Editor, Journal of Bacteriology 1996 NIH MERIT Award 1996 Division M Lecturer, ASM, New Orleans 1992-96 Member, Microbial Physiology and Genetics Study Section (MBC-2) 1990 Howard Hughes Predoctoral Fellowship Review Panel (also 91, 98, 00; Chair, Genetics 1, 01) 1988-99 Editorial Board, Journal of Bacteriology 1968 Woodrow Wilson National Designate

PHS 398/2590 (Rev. 09/04) Page 1 Biographical Sketch Format Page Principal Investigator/Program Director (Last, First, Middle):

B. Peer-reviewed Publications, last 5 years (in chronological order; from 106 total)

Summer, E.J., Enderle, C.J., Ahern, S.J., Gill, J.J., Torres, C.P., Appel, D.N., Black, M.C., Young, R., and Gonzalez, C.F. (2009) Genomic and biological analysis of phage Xfas53 and related prophages of Xylella fastidiosa. (in press). Carmody, L.A., Gill, J.J., Sajjan, U.S., Gonzalez, C.F., Young, R.F., and LiPuma, J.J. (2009) Efficacy of bacteriphage therapy in model of Burkholderia pulmonary infection. (in press). Pang, T., Savva, C.G., Fleming, K.G., Struck, D.K. and Young, R. (2009) The structure of the lethal phage pinhole. Proc Nat Acad Sci USA (in press). Sun, Q., Kuty, G.F., Arockiasamy, A., Xu, M., Young, R. and Sacchettini, J.C. (2009) Regulation of a muralytic enzyme by dynamic membrane topology. Nature Structural Biology (in press). Dewey, J.S., Struck, D.K., Young, R. (2009) Thiol protection in membrane protein purifications: a study with phage holins. Anal. Biochem 390:221-223. Zheng, Y., Struck, D.K., and Young, R. (2009) Purification and functional characterization of the φX174 lysis protein E. Biochemistry 48:4999-5006. Zheng, Y., Struck, D.K., Bernhardt, T.G. and Young, R. (2008) Genetic analysis of MraY inhibition by the φX174 protein E. Genetics 180:1459-1466. Berry, J., Summer, E.J., Struck, D.K., and Young, R. (2008) The final step in the phage infection cycle: the Rz and Rz1 lysis proteins link the inner and outer membranes. Mol. Microbiol. 70:341-51. Young, R.F. (2008) Secret weapon. Science 321: 922-923. Young, R.F. and White, R.L. (2008) Lysis of the host by bacteriophage. Encyclopedia of Virology. 5:249- 258. Zheng, Y., Struck, D.K., Dankenbring, C.A., and Young, R. (2008) Evolutionary dominance of holin lysis systems derives from superior genetic malleability. Microbiology 154:1710-1718. Savva, C., Dewey, J., Deaton, J., White, R., Struck, D., Holzenburg, A., and Young, R. (2008) The holin of bacteriophage lambda forms rings with large diameter. Molecular Microbiology 69:784-793. Park, T., Struck, D. K., and Young, R. (2007) The pinholin of lambdoid phage 21: control of lysis by membrane depolarization. J. Bacteriol. 189:9135-39. Summer, E.J., Berry, J., Tran T.A., Niu, L., Struck, D.K., and Young, R. (2007) Rz/Rz1 lysis gene equivalents in phages of Gram-negative hosts. J. Mol. Biol.373: 1098-112. Tran, T.A.T., Struck, D.K., and Young, R. (2007) The T4 RI antiholin has an N-terminal SAR-domain that targets it for degradation by DegP. J. Bacteriol. 189:7618-25. Summer, E.J., Gill, J., Upton, C., Gonzalez, C.F. and Young,R. (2007)Role of phages in the pathogenesis of Burkholderia or "Where are the toxin genes in Burkholderia phages?" Curr. Opin. Microbiol. 10:410-7. Park, T., Struck, D.K., Deaton, J.F. and Young,R. (2006) Topological dynamics of holins in programmed bacterial lysis. Proc. Natl. Acad. Sci. USA 103:19713-8. Young, R., Henkin, T.M., Turnbough, C. L. (2006) The phage meeting: Classical venue, new momentum. J Bacteriol.188:4597-600. Summer, E.J., Gonzalez, C.F., Bomer,M., Carlile, T., Embry, A., Kucherka, A.M., Lee, J., Mebane, L. Morrison, W.C., Mark, L., King, M.D., LiPuma, J.J., Vidaver, A.K., and Young, R. (2006) Divergence and mosaicism among virulent soil phages of the Burkholderia cepacia complex. J. Bacteriol. 188:255- 68. Kish, L. B., Cheng, M., Kim, J. U., Seo, S., King, M. D., Young, R., Der, A., and Schmera, G. (2005) Estimation of detection limits of the phage-invasion based identification of bacteria. Fluct. Noise Lett. 5: L105 - 8. Tran, T.A.T., Struck,D.K., and Young,R. (2005) The role of holin and antiholin periplasmic domains in T4 lysis inhibition. J. Bacteriol. 187: 6631–40. Adhya, S., Black, L., Friedman, D., Hatful, G., Kreuzer, K., Merril, C., Oppenheim, A., Rohwer, F., and Young, R. (2005) 2004 ASM Conference on the New Phage Biology: the ‘Phage Summit’. Molec. Microbiol. 55:1300-14.

PHS 398/2590 (Rev. 09/04) Page 2 Continuation Format Page Curriculum Vita Joshua Shuhua Yuan

Professional Experience 2008 – Assistant Professor in Bioinformatics and Systems Biology Institute of Plant Genomics and Biotechnology & Department of Plant Pathology and Microbiology Texas A&M University, College Station, TX 2004 – 2008 Genomics Scientist, Department of Plant Sciences, Director, UTIA Genomics Hub, University of Tennessee, Knoxville, TN 2001 – 2004: Microarray Core Manager, Ernest Gallo Clinic & Research Center, University of California, San Francisco, CA 2000 – 2001: Senior Research Associate, BASF Plant Sciences LLC, RTP, NC

Education Ph.D. Major: Plants, Soils and Insects University of Tennessee 2007 Focus: Functional Genomics Minor: Statistics M.S. Plant Sciences University of Arizona 2001 B.S. Major: Biology Fudan University 1997 Minor: International Economics

Teaching BESC489/PLPA689: Biotechnology for Biofuels and Bioproducts, Spring, 2009 Life Sciences 595 and Nutrition 549: Microarray Technology and Database Application, Fall, 2007 (http://mediabeast.ites.utk.edu/mediasite4/Catalog/Front.aspx?cid=9f63cd71- 1ebd-4c94-9e3a-6c1a94a1788b) Plant Sciences 494/594: Plant Biotechniques (Genomics Part), Fall, 2006 and 2007

Honor Sigma Delta Gamma Outstanding Graduate Student, 2007

Editorial Positions 2008 – now BMC Research Notes Associate Editor

Professional Membership American Society of Plant Biologist International Society for Computational Biology

Talks in National and International Symposia and Workshops 1. Speaker: Cross-platform Sequencing Analysis to Dissect the Molecular Mechanisms for Non-target Site Herbicide Resistance in Horseweed. Plant and Animal Genome, San Diego, CA, January 2009 2. Speaker: Genomic, Transcriptomic, Proteomic and Functional Analysis of Candidate Genes for Bioenergy Feedstock Improvement, 30th Symposium on Biotechnology for Fuels and Chemicals, New Orleans, May 2008 3. Speaker: Toward Ultimate Quantification - Recent Advances in Statistical Analysis of Real-Time PCR Data with Linear Models, Quantitive PCR, Replicating and Validating Success, CHI, San Diego, CA, April 2008 4. Speaker: Statistical Analysis of Real-time PCR with Linear Models, UT-ORNL-KRBIN Bioinformatics Summit, Lake Bakeley, KY, March 2008

1 5. Speaker: Metabolic, Genomic, and Biochemical Analysis of Novel Genes Involved in Rice Indirect Defense against Herbivore Insects, 5th International Symposium of Rice Functional Genomics, Tsukuba, Japan, October 2007 6. Lecturer: Pre-conference Short-course: Statistical Analysis of Real-time PCR Data, Quantitative PCR, Replicating and Validating Process, Cambridge Health Institute, San Diego, CA, March 2007 7. Speaker: Efficiency Adjusted Real-time PCR Data Analysis, The Fourth Annual Conference of the MidSouth Computational Biology and Bioinformatics Society, New Orleans, LA, February 2007 8. Speaker: Non-target Herbicide Resistance: a Family Business, Weedy and Invasive Plant Workshop, Plant and Animal Genome Conference XV, San Diego, CA, January 2007 9. Lecturer: Pre-conference Short-course, Statistical Analysis of Real-time PCR Data, Quantitative PCR, Microarrays, and Biological Validation Conference, CHI, Providence, RI, October 2006 10. Speaker: Identifying and Characterizing Rice Terpene Synthase Genes Involved in Insect Defense Using An Integrated Functional Genomic Approach, Secondary Metabolism Minisymposium, Annual Conference American Society of Plant Biologist 2006, Boston, MA, August 2006 11. Plenary Speaker: Gene Profiling of Drosophila Mushroom Body, the 3rd Northwest Microarray Conference, Seattle, Washington, August 2002

Publications 1. Trigiano, R.N., X.W. Wang, L.L. Good, D. Panthee, B.E. Scheffler, T.A. Rinehart, D. Johnson, P.A. Wadl, N.R. Stewart, J.S. Yuan, C.N. Stewart, Jr. Microsatellites from Conyza canadensis (horseweed). Submitted. 2. Wayra Navia-Gine, Joshua S. Yuan, Feng Chen, and Kenneth L. Korth, Regulation of an insect-induced E-(beta)-ocimene synthase and other terpene synthases of Medicago truncatula. In press in Plant Physiology and Biochemistry. 3. Joshua S. Yuan, Sari J. Himanen, Jarmo K. Holopainen, Feng Chen, and C. Neal Stewart, Jr. Smelling global warming: changes of ecological function of plant volatile organic compounds, In press in Trends in Ecology and Evolution. 4. Panthee, D.R., J.J. Marois, D.L. Wright, J.S. Yuan, and C.N. Stewart Jr. Differential expression of genes in soybean in response to the causal agent of Asian soybean rust, (Phakopsora pachyrhizi Sydow), is soybean growth stage-specific. 2009, Theoretical and Applied Genetics, 118: 359-370. 5. Joshua S. Yuan, Tobias G. Köllner, Greg Wiggins, Jerome Grant, Nan Zhao, Xiaofeng Zhuang, Jörg Degenhardt and Feng Chen Elucidation of the genomic basis of indirect plant defense against insects, 2008, Plant Signaling & Behavior, 3: 720 - 721 6. Jason Abercrombie, Matthew Halfhill, Priya Ranjan, Murali Rao, Arnold Saxton, Joshua S. Yuan, C. Neal Stewart Jr., Transcriptional profiling of Arabidopsis thaliana grown under arsenate stress reveals antioxidant activity and repression of the phosphate starvation response, 2008, BMC Plant Biology, 8:37. 7. Joshua S. Yuan, Jonathan R. Mielenz, Kelly H. Tiller, Nathan R. Stewart, C. Neal Stewart Jr., Plants to power: Bioenergy to fuel the future, 2008, Trends in Plant Sciences, 13:421-429. 8. Joshua S. Yuan, Tobias G. Köllner, Greg Wiggins, Jerome Grant, Jörg Degenhardt, and Feng Chen, Molecular and genomic basis of volatile-mediated indirect defense against insects in rice, 2008, Plant Journal, 55: 491-503

2 Hongbin Zhang

Current Title: Professor of Plant Genomics and Molecular Genetics

Appointment: 80% research, 20% teaching

Physical Address: 427A Heep Center, Texas A&M University, College Station, Texas 77843-2474

Email Address: [email protected]

Education: Ph.D., Genetics, University of California, Davis, California. 1990. Ph.D. Study, Plant Biochemistry and Physiology, Utah State University, Utah. 1985 - 1986. M. S., Cytogenetics, Chinese Academy of Agricultural Sciences, Beijing, China. 1984. B. S., Plant Genetics and Breeding, Agricultural University of Hebei, Hebei, China. 1982.

Teaching Focus: Analysis of Complex Genomes (AGRO, GENE and MEPS 655) Directed Studies in Genomics and Genetics for graduate students (AGRO and GENE 685) Directed Studies in Genomics and Genetics for undergraduate students (GENE 485) Advisor for 18 undergraduate student fellows, 1996 – present; advisor for 8 graduate student fellows; and advisor for 10 postdoctoral fellows, 1996 – present Major advisor for 8 M.S. and 4 Ph.D. students, 1996 – present.

Research & Extension Focus: Grants and Contracts: Principal or co-principal investigator for 24 projects from 1996 – present in a total of $14,276,317, of which >$5,400,000 are/were for Zhang’s programs. The funds were from federal and state agencies and other public and private organizations such as NSF/Plant Genome, NSF/BAC Library Construction, USDA/NRI, USDA/IFAFS, USDA/CSREES, USDA/1890, USDA/BARD, NIH, Texas Advanced Technology Research Program, Texas Cotton Biotechnology Initiative, Rockefeller Foundation, DuPont, etc.

Publications: 219 in total, of which peer-refereed journal publications – 73, non-peer, editor- reviewed publications – 2, manual books – 3, book chapters – 7, encyclopedia section – 1, conference or symposium proceedings – 9, and presentations and abstracts in international or national scientific conferences or symposium – 124.

Patents and Genomic Resources Released: U.S. patents – 2, BAC, BIBAC and TAC library resources – 94, and whole-genome BAC/BIBAC-based physical maps – 7

Professional Accomplishments: • Helped pioneer the BAC and BIBAC technologies, developed nearly 200 arrayed, large- insert BAC and BIBAC libraries for plant and animal species, and established a genomic resources center (The GENEfinder Genomic Resources Center at http://hbz7.tamu.edu) for enhanced genome research and gene discovery. These library resources represent a largest collection of arrayed BAC and BIBAC libraries worldwide, and have significantly accelerated plant and animal genomic research. Because of these achievements, five international BAC and BIBAC workshops were organized at which a large number of genome scientists were trained. In addition, 49 genome scientists from 13 countries visited and were trained in Zhang’s laboratory in the technologies. • Helped pioneer the whole-genome physical mapping technologies with BACs and developed the whole-genome BAC/BIBAC physical maps of indica rice, japonica rice, Arabidopsis, soybean, chicken, Ustilago maydis, Penicillium chrysogenum, Phytophthora sojae, red algae, and cotton. These physical maps have provided essential and powerful platforms for large-scale, high-throughput gene mapping, marker development, gene/QTL mapping, genome sequencing, and genome analysis. • Discovered new structure of DNA molecules that is expected to extend the DNA double helix theory and determined the organization, function and evolution patterns of DNA molecules at the genomic level. • Identified all DNA clones containing genes conferring resistance to fungi, bacteria, viruses and nematodes in indica rice, japonica rice, soybean and cotton, and determined the organization and evolution of plant disease resistant genes in the plant genomes. The results have provided better understanding of host-pathogen interactions and molecular basis to design new biological approaches to effective control of pathogens in agriculture. • Reconstructed the phylogeny of the genus Gossypium, deciphered the underlying mechanism of plant genome size evolution, and determined the impacts of domestication, breeding and polyploidization on plant genome organization and evolution. • Identified > 2,000 genes that are involved in maize heterosis. These genes have provided new tools for our understanding of molecular basis of heterosis in plants and animals. • Taught and trained more 200 students, postdoctoral fellows and genome scientists in genomics and applications of genomic tools in plant breeding.

Recent Publication (limit to 10 most recent): 1. Lichtenzveig J, Bonfil, DJ, Zhang H-B, Shtienberg D, Abbo S. 2006. Mapping quantitative trait loci associated with time to flowering and resistance to Didymella rabiei, the causal agent of Ascochyta blight. Theor. Appl. Genet. (in press). 2. Broggini GAL, Le Cam B, Parisi L, Wu C, Zhang H-B, Gessler C, Patocchi A. 2006. Construction of a contig of BAC clones spanning the region of the apple scab avirulence gene Avr Vg. Fungal Genetics and Biology (in press). 3. He L, Du C, Li Y, Scheuring C, Zhang H.-B. 2006. Large-insert bacterial clone libraries and their applications. In: Aquaculture Genome Technologies. Z. Liu (ed.). Blackwell Publishing, Ames, Iowa, USA (in press) 4. McPhee KE, Croser J, Sarma B, Ali SS, Amla D, Rajesh PN, Zhang H-B. 2006. Development of transgenics in chickpea. In: Chickpea. Yadav SS, Redden B, Chen W, Sharma B (eds.). CABI, UK (in press) 5. Zhang X, Scheuring C, Tripathy S, Xu Z, Wu C, Ko A, Tian SK, Arredond F, Lee M-K, Santos AF, Zhang H-B, Tyler BM. 2006. An integrated BAC and genome sequence physical map of Phytophthora sojae. Molecular Plant-Microbe Interactions 19: 1302-1310. 6. Tyler BM, Tripathy S, Zhang X, Dehal P, Jiang RHY, Aerts A, Arredondo FD, Baxter L, Bensasson D, Beynon JL, Chapman J, Damasceno CMB, Dorrance AE, Dou D, Dickerman AW, Dubchak IL, Garbelotto M, Gijzen M, Gordon SG, Govers F, Grunwald NJ, Huang W, Ivors KL, Jones RW, Kamoun S, Krampis K, Lamour KH, Lee M-K, Maclean DJ, McDonald WH, Medina M, Meijer HJG, Morris PF, Nordberg EK, Ospina-Giraldo MD, Phuntumart V, Putnam NH, Rash S, Rose JKC, Sakihama Y, Salamov AA, Savidor A, Scheuring CF, Smith BM, Sobral BWS, Terry A, Torto-Alalibo TA, Win J, Xu Z, Zhang H-B, Grigoriev IV, Rokhsar DS, Boore JL. 2006. Phytophthora genome sequences uncover evolutionary origins and mechanisms of pathogenesis. Science 313: 1261-1266. 7. Wu C, Wang S, Zhang H-B. 2006. Interactions among genomic structure, function and evolution revealed by comprehensive analysis of the Arabidopsis genome. Genomics 88:394-406. Principal Investigator/Program Director (Last, First, Middle): ZHOU, HUAIJUN BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Huaijun Zhou Assistant Professor eRA COMMONS USER NAME HJZHOU EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) DEGREE INSTITUTION AND LOCATION YEAR(s) FIELD OF STUDY (if applicable) Yangzhou University, Yangzhou, China B.S. 1984-88 Animal Science Yangzhou University, Yangzhou, China M.S. 1988-91 Animal Genetics Immunogenetics Iowa State University, Ames, Iowa Ph.D. 1999-02 and Molecular Genetics Bioinformatics and Iowa State University, Ames, Iowa M.S. 2000-03 Computational Biology Iowa State University, Ames, Iowa Postdoc 2003-04 Functional Genomics Agriculture and Agi-Food Canada, Guelph, Canada Fellow 2004-06 Immunogenomics

POSITIONS AND HONORS Positions and Employment 1991 – 93 Research Associate Animal Genetics, Institute of Poultry Science, Chinese Academy of Agriculture Science, Yangzhou, China 1993 – 98 Research Assistant Professor Animal Genetics, Institute of Poultry Science, Chinese Academy of Agriculture Science, Yangzhou, China 1998 – 99 Visiting Scientist Animal Science, Iowa State University, Ames, IA 1999 – 02 Research Assistant Animal Science, Iowa State University, Ames, IA 2002 – 04 Research Associate Animal Science, Iowa State University, Ames, IA 2004 – 06 Visiting Fellow Food research, Agriculture and Agi-Food Canada, Guelph, Canada 2006 – Assistant Professor Poultry Science, Texas A&M Univ., College Station, TX Honors and Other Professional Activities 2009 Big XII Faculty Fellow 2009 Ad hoc reviewer for European Science Foundation 2008 Review Panelist, NSF GRFP (Genetics and Evolutionary Biology) 2008 Ad hoc reviewer for NSF/USDA Microbial Genomics 2008 Ad hoc reviewer for French National Research Agency (Animal Genomics) 2008 Ad hoc reviewer for U.S. Civilian Research & Development Foundation 2008 Ad hoc reviewer for NSF China (Animal Genome) 2007, 2009 Review Panelist, USDA National Research Initiative (Animal Genome) 2006 Ad hoc reviewer for USDA/CSREES Special Research Grant 2006- Associate editor, Poultry Science 2006- Ad hoc reviewer for Proceedings of the National Academy of Sciences of USA, Trends in Microbiology, Journal of Heredity, BMC Bioinformatics, Animal Genetics, Gene, Avian Pathology, Molecular and Developmental Evolution, Biochimie, Genetics and Molecular Biology, Archives of Microbiology, International Journal of Biological Sciences. Teaching Current topics in genomics (graduate) Poultry breeding and genetics (undergraduate)

PHS 398/2590 (Rev. 05/01) Page 1 Continuation Format Page Principal Investigator/Program Director (Last, First, Middle): ZHOU, Huaijun MAJOR RECENT PUBLICATIONS (Since 2005, from a total number of 41) 1. Chiang HI, LR. Berghman, H. Zhou. 2009. Inhibition of NF-kB 1 (NF-kBp50) by RNA interference in chicken macrophage HD11 cell line challenged with Salmonella enteritidis. Genetics and Molecular Biology Accepted for publication. 2. Zhou H, J. Gong, J. Brisbin, H. Yu, A. Sarson, W. Si, S. Sharif, and Y. Han. 2009. Transcriptional Profiling Analysis of Host response to Clostridium perfringens Infection in Broilers. Poult. Sci. In press. 3. Wang J. G. Wu. H. Zhou. F. Wang. 2009. Emerging technologies for amino acid nutrition research in the post-genome era. Amino Acids. 37:177-186. 4. E. Koren, H. Zhou, A. Cahaner, E.D. Heller, J. Pitcovski, S.J. Lamont. 2008 . Unique Co-expression of Immune Cell-related Genes in IBDV Resistant Chickens Indicates the Activation of Specific Cellular Host-response Mechanisms. In : Pinard M-H, Gay C, Pastoret P-P, Dodet B (eds): Animal Genomics for Animal Health. Dev Biol (Basel). Basel, Karger, 2008, vol 132, p 153-159. 5. H.I. Chiang,, C. Swaggerty, M. Kogut, S. Dowd, X. Li, I. Pevzner, and H. Zhou. 2008. Gene expression profiling in chicken heterophils with Salmonella enteritidis stimulation using a chicken 44K Agilent microarray BMC Genomics 9:526. 6. Wang J, L. Chen, P. Li, X. Li, H. Zhou, F. Wang, D. Li, Y. Yin, and G. Wu. 2008. Gene expression is altered in piglet small intestine by weaning and dietary glutamine supplementation. J. Nutrition 138:1025-1032. 7. Li X., C. L. Swaggerty, M. H. Kogut, H. Chiang, Y. Wang, K. J. Genovese, H. He, N. J. Stern, I. Y. Pevzner, H. Zhou. 2008. The Paternal Effect of Campylobacter jejuni Colonization in Ceca in Broilers. Poult. Sci. 87:1742-1747. 8. X.Y. Li, H.I. Chiang, J. Zhu, S. Dowd and H. Zhou. 2008. Characterization of newly developed chicken 44K Agilent microarray. BMC Genomics 9:60. 9. Brisbin, J. T.*, H. Zhou*, J. Gong, P. Sabour, M. R. Akbari1, H. R. Haghighi1, H. Yu, A. Clarke, A. J. Sarson, and S. Sharif. 2007. Gene expression profiling of chicken lymphoid cells after treatment with Lactobacillus acidophilus cellular components. Dev. Comp. Immunol. 32:563-74. 10. Zhou, H., J. Gong, J. T. Brisbin, H. Yu, B. Sanei, P. Sabour, and S. Sharif. 2007. Appropriate Chicken Sample Size for Identifying the Composition of Broiler Intestinal Microbiota Affected by Dietary Antibiotics using the PCR-DGGE Technique. Poult. Sci. 86:2541-9. 21. Wong, G. K., B. Liu, , J. Wang, et al. (H. Zhou was one of 115 co-authors in the consortium). 2004. A genetic variation map for chicken 2.8 million single nucleotide polymorphisms. Nature 432, 717-722. RESEARCH SUPPORT Ongoing Research Support

USDA, CSREES, NRI (National Research Initiative Competitive Grants Program - Animal Genome) 2007-35604-17903 Zhou H. (PI) 2007/09/01- 2009/08/31 Elucidate Cellular and Molecular Mechanisms of Genetic Control of Campylobacter Colonization in Chickens Using Whole Genome Array.

USDA Formula Animal Health Fund 07-024 Zhou H. (PI) 2007/06/01- 2009/05/31 Characterization of chicken microRNA and their regulatory roles in the pathogenesis of H5N3 avian influenza virus

Cobb-Vantress Inc. Zhou H. (PI) 2007/10/01- 2009/09/30 Gene expression profiling of different Mx genotypes in avian influenza virus infected embryo and chickens.

NIH, NIAID 1R21AI080022-01 Zhou H. (Co-I) 2008/9/25- 2010/8/31 Host cell proteins that interact with Cryptosporidium

PHS 398/2590 (Rev. 09/04) Page 2 Continuation Format Page

APPENDIX K List of Biotechnology program faculty who have taught BIOT classes

BIOT Faculty Courses Taught Ball Judy BIOT 603, 684 Berghman Luc BIOT 603 Burghardt Robert BIOT 603 Cheng Zhengdong BIOT 603 Coates Craig BIOT 603 Cornwell Brett BIOT 603 Cudd Timothy BIOT 603 Defigueiredo Paul BIOT 603 Derr James BIOT 603, 684 Faridi Nurul BIOT 603 Gastel Barbara BIOT 684 Gill Clare BIOT 601, 602, 603,635, 684 Hall Tim BIOT 603 Hilty Christian BIOT 603 Ing Nancy BIOT 601, 602, 603 Jayaraman Arul BIOT 603 Loopstra Carol BIOT 684 Ng Desmond BIOT 603 Nikolov Zivko BIOT 603, 684 Parr Rebecca BIOT 601, 603 Pillai Suresh BIOT 603, 681, 684 Rathore Keerti BIOT 602, 603, 684 Safe Steve BIOT 603 Samuel James BIOT 603 Skow Loren BIOT 684 Sturino Joseph BIOT 603, 684 Welsh Jane BIOT 603, 684 Young Colin BIOT 645, VIBS 685 Yuan Joshua BIOT 603

APPENDIX L Student Matriculating Semester Committee Chair

Jani, Bhairavi 07 spring Nikolov, Zivko Maheshwari, Mukesh 07 spring Ball, Judith Mohan, Ashwin 07 fall Gill, Clare Owolabi, Oluwafunmike 07 fall Pillai, Suresh Develpally, Krishna 08 spring Pillai, Suresh Hulsurkar, Mohit 08 spring Pillai, Suresh Krishnaveni, Sivakumar 08 spring Pillai, Suresh Murthi, Poornima 08 spring Pillai, Suresh Shaik, Shazia 08 spring Sturino, Joseph Bagai, Varun 08 fall Sturino, Joseph Balasundara, Sivanandam 08 fall Sturino, Joseph Bondre, Aniket 08 fall Pillai, Suresh Desai, Krunal 08 fall Hilty, Christian Dewsbury, Nathan 08 fall Derr, James Ghosh, Souvik 08 fall Hilty, Christian Jiang, Lan 08 fall Samuel, James Konda, Shruti 08 fall Sturino, Joseph Krishna,Meghana 08 fall Hilty, Christian Lin, Yu-His 08 fall Ing, Nancy Mattegunta, Venkata 08 fall Berghman, Luc Nanneti, Philips 08 fall Sturino, Joseph Pathi, Anupama 08 fall Sturino, Joseph Pisupati, Tejeswini 08 fall Sturino, Joseph Pollard, Dylan 08 fall Pillai, Suresh Ramakrishnan, Dhivya 08 fall Welsh, Jane Rana, Gunjot 08 fall Gill, Clare Sawant, Onkar 08 fall Cudd, Timothy Sherekar, Mukul 08 fall Yuan, Joshua Gurvani, Singh 09 fall Not yet chosen Janes, Christopher 09 fall Not yet chosen Johnson, Matthew 09 fall Not yet chosen Knandelwal, Vidhi 09 fall Not yet chosen Kohli, Karan 09 fall Not yet chosen Scaparra, Joan 09 fall Not yet chosen Yeh, Shen-Mei 09 fall Not yet chosen

Faculty serving on BIOT student committees--Fall 2009 Name Number of student committees Joseph Sturino 12 Suresh Pillai 10 Judith Ball 8 Clare Gill 8 Jane Welsh 5 Colin Young 4 Christian Hilty 4 Mark Holtzapple 3 Wenshe Lui 2 Thomas Taylor 2 Jim Derr 2 Keerti Rathore 2 Victoria Buenger 2 Leonard Bierman 1 Mike Criscitiello 1 Sangeeta Khare 1 Jim Wild 1 Alejandro Castillo Ayala 1 Jimmy Keeton 1 Paul Defigueiredo 1 Zivko Nikolov 1 James Samuel 1 Deborah Siegele 1 Larry Gresham 1 Melissa Grunlan 1 Nancy Ing 1 Rebecca Parr 1 Jean Gould 1 Luc Berghman 1 Joseph Coombs 1 Timothy Cudd 1 Rajesh Miranda 1 Yanan Tian 1 Sandun Fernando 1 Victor Ugaz 1 Shuhua (Joshua) Yuan 1

APPENDIX M “Biotechnology is stepping in and making the Helpful Websites biological sciences more accessible. It’s making medicines more effective with fewer side effects, Biotechnology Program Texas A&M Office of Graduate Studies building stronger and healthier crops, preventing www.tamu.edu/ppib http://ogs.tamu.edu spoilage in food, and fighting diseases that were once incurable. I chose the Professional Program Texas A&M University Admissions and Records www.tamu.edu www.tamu.edu/admissions in Biotechnology because I want to be at the heart of these new technologies. I want to be in the Bryan–College Station Off-Campus Housing middle, where science and business meet. This www.visitaggieland.com http://studentlife.tamu.edu/agoss program is perfect because it allows me to study Professional Program the science I’m passionate about in a business Student Business Services International Student Services setting.” http://finance.tamu.edu/sbs http://international.tamu.edu/iss – Liz Mitchell, Program Graduate in Biotechnology

“The Professional Program in Biotechnology is a unique program compared to other biotechnology programs in the United States. It is unique because the curriculum combines cutting- edge biotechnology laboratory training with contemporary business and marketing courses. A highlight of the program is the active participation of the Industry Advisory Council, made up of leaders in the biotechnology industry.” – Dr. Suresh Pillai, Chair, PPiB

For more information, please contact: Professional Program in Biotechnology Texas A&M University 2472 TAMU 388 Kleberg Center “I chose the Professional Program in Biotechnology College Station, TX 77843-2472 because I wanted an understanding of the Phone: (979) 862-4935 science as it applies to business. Courses from Fax: (979) 845-1921 E-mail: [email protected] marketing to project management have given me Web: www.tamu.edu/ppib a foundation to build upon. The PPiB has definitely placed me in a position where I can make a real impact in the biotechnology industry.” – Paul Martinez, Program Graduate “The Austin biotech community is united in its support for the master’s degree “The Professional Program in Biotechnology is a home run for our companies, which program in biotechnology at Texas A&M University. We believe strongly in the need professionals who can integrate the science and business of biotechnology. As the commitment A&M is making to prepare students for careers in biotechnology, region’s life science industry grows, the PPiB will play an increasingly significant role in whether the student’s interest lies in academics, industry, or government.” meeting the workforce needs of this emerging biotech-based economic engine.”

— Bruce Leander, former President, Ambion, Inc., and former Chairman, BioAustin — Jason Moore, PLX Pharma, Inc.

Biotechnology A Multifaceted Program

As technology and scientific discoveries continue to advance, Faculty members from five colleges across Texas A&M University and biotechnology will play an increasing role. Having the skills and the Biotechnology Program Industry Advisory Council offer a unique knowledge of both science and business can help you succeed in variety and breadth of knowledge. The participating colleges are: a biotechnology career. • College of Agriculture and Life Sciences One of the first Professional Science Master’s programs in the nation, • College of Science the Professional Program in Biotechnology (PPiB) at Texas A&M • Mays Business School University can help you prepare for a rewarding and challenging • Dwight Look College of Engineering career in biotechnology. • College of Veterinary Medicine and Biomedical Sciences

This four-semester, cross-disciplinary, non-thesis program, which leads The program ensures practical, hands-on laboratory experience to a Master of Biotechnology (MBIOT) degree, provides you with skills while developing crucial networking skills for first-class working vital to both the science and the business aspects of the biotechnology professionals. industry. Take the First Step the site once your application is complete and received by Graduates of this program are in high demand and work in a variety Texas A&M University. of fields, ranging from research and development of new drugs and Requirements for Admission (www.tamu.edu/ppib) • Have official transcripts sent to Graduate Admissions medical devices to the manufacturing, sales and marketing of • Baccalaureate degree with 3.0 or higher grade point ratio Processing, Office of Admissions and Records, Texas A&M molecular biotechnology products and services. (GPR) overall University, P. O. Box 40001, College Station, TX 77842-4001, USA. • GRE scores • Have GRE or TOEFL scores sent directly to Texas A&M University This interdisciplinary program caters to your individual needs and • TOEFL (Test of English as a Foreign Language) scores for (Code 6003). offers rigorous academic training that includes: international students • Three letters of reference and evaluation forms Application Deadline • Molecular biotechnology and genomics • Career goals essay • International students: March 1 for fall admission • Technical writing • U.S. domestic students: June 1 for fall admission • Semester-long industry internship Application Process (www.tamu.edu/ppib) • Hands-on laboratory-based research • Complete the Texas Common Application (www.applytexas.org) Financial Aid • Marketing including an essay on your career goals. • A limited number of scholarships that waive non-resident tuition • Management • Arrange for three letters of recommendation to be sent via the are available on a competitive basis. • Accounting and finance Application Information System Website. You will have access to

APPENDIX N

BIOT 684— Directed Professional Internship

and

Professional Portfolio

HandbookHandbook

Student

PPiB Marian Cothran Program Coordinator August, 2009

1

TABLE OF CONTENTS

INTRODUCTION ...... 4

OBTAINING AN INTERNSHIP ...... 5

PAPERWORK REQUIREMENTS ...... 7

WRITING LEARNING OBJECTIVES ...... 9

PROFESSIONAL PORTFOLIO GUIDELINES ...... Handbook 11

Internship Preparation Documents ...... 11

Section 1—Reflection on Coursework and Competencies ...... 12

Section 2—ReflectionStudent on Internship ...... 13

BIOT 684 EVALUATION AND FINAL EXAM ...... 14 PPiB

2

APPENDICES

Appendix A‐‐Former Students ...... 15

Appendix B—BIOT Internship Sites ...... 18

Appendix C—Program Advisory Council ...... 20

Appendix D—Program Faculty ...... 22 Appendix E—Internship Description Form ...... Handbook 24 Appendix F—Learning Agreement ...... 26

Appendix G—Mid‐term Evaluation by Supervisor ...... 29

Appendix H—Final Evaluation by Supervisor ...... 32 Student Appendix I—Student Evaluation of Site ...... 35 AppendixPPiB J—Confidentiality Memo ...... 37 Appendix K—Sample Table of Contents ...... 39

3

INTRODUCTION

BIOT 684—Directed Professional Internship is possibly the most important course in your career as a biotechnology student because it allows you to apply your training and learn from real‐world work experiences. The objectives of the internship course are two‐fold. First, it is of value because it allows you to use your training to make an identifiable contribution of practical concern to the organization offering the internship. That is, you will be solving a problem or creating a new product or knowledge for the biotech industry. Secondly, this internship will allow you to function in a non‐academic environment with a different culture and approach to management, public relations, and other endeavors. This awareness of the work world will give you confidence as you begin the process of seeking a job. And some internships will result in job offers!

The Professional Program in Biotechnology (PPiB) requires a minimum of 10 weeks of full‐time employment (40 hours/week) for successful completion of the internship requirement. The internship can be paid or unpaid. The internship is normally scheduled for the summer between the first and second years of study in the program. This is to take advantage of the fact that almost all formal, dedicated internship programs of companies are offered in the summer. There are a limited number of internships and coops offered during the fall and spring semesters for those students unable to obtain a summer internship. Prior to the internship the student sets goals for the internship, and these are formalized in the PPiB Learning Agreement along with a listing of responsibilitiesHandbook for all parties to the agreement.

Our preference is for students to obtain internship employment in the biotech industry; however, employment at other academic institutions or Texas A&M University affiliates, such as the Institute of Biosciences and Technology or the Office of Technology Commercialization, is acceptable. If you have completed all other coursework, you may accept a job before graduation and use the first several months of your job to fulfill the internship requirement, as long as the company meets their internship responsibilities outlined in the PPiB Learning Agreement.

An additional degree requirement for the Professional Program in Biotechnology is the creation of a professionalStudent portfolio. This portfolio contains a section in which you reflect on all coursework and program competencies, and a section reflecting on the internship. Upon completion of your portfolio, your will give a public presentation on your internship experience followed by an oral exam by your faculty committee members. They will quiz you on what you did and the science and business principles behind applications.

This handbook is designed to clarify the internship process and to gather in one place all thePPiB paperwork and tools needed to create a successful portfolio and presentation. You will find information on obtaining an internship, paperwork requirement, writing learning objectives, portfolio guidelines, and evaluation of both BIOT 684 and the portfolio examination.

4

OBTAINING AN INTERNSHIP

One of the biggest mistakes of most students is waiting too long to begin their internship search. Especially in today’s economic climate, you need to begin your search nine months before the anticipated start date for the internship. That is, for a summer internship, you must begin searching in your first semester in the program.

The first step in a search is to decide on the kind of internship you want. Are you more interested in the business aspects of biotechnology, or do you want to be working at the lab bench doing your magic? Research the different types of jobs and employers in the biotech industry. You can begin this exploration on the web, but I highly recommend you check out the resources offered by the Texas A&M Career Center, located in 209 Koldus Building on main campus. They offer appointments with career counselors, workshops on everything from resume building to job interviews, and an extensive career resources library. Finally the Career Center hosts the annual Sciences Career Fair held each September. Do not miss this opportunity to meet and gather information from industry recruiters that attend the fair.

Early on you should also decide where to focus your internship search. Most companies hire interns locally from colleges and universities. So it makes sense to focus intensively on the Austin and Houston biotech markets closest to campus. That said, do not ignore East and West coast areas where the majority of biotech firms are located. If you have family or other contacts in those areas that can share lodging for the tenureHandbook of the internship, that is an important consideration. It can allow you to work in areas with high cost‐of‐living and still make ends meet.

Once you have decided what you would like to do and where you would like to do it, you need to begin networking in earnest. Networking is one of the most effective tools in a job search. Be persistent and pursue any leads that come up. Ask professors, friends, and family for names of people to contact about an internship. If they don’t know of anything, ask if they know of someone who could help. Join a professional organization or social networking site. I recommend the following: • Texas A&M Biotechnology Society, http://biotech.tamu.edu • The National ProfessionalStudent Science Masters Association, www.npsma.org. Your first year of membership is free. • The PPiB LinkedIn group, www.linkedin.com and search for our group. • The PPiB Facebook page, www.facebook.com and search for our group.

Included in Appendix A of the Handbook is a listing of former biotechnology (BIOT) students that may be helpful in your search. Also, organizations that have offered internships to BIOT studentsPPiB in the past are more likely to offer internships to our program students again. Check out Appendix B for a list of places where our former students have interned. Our program Advisory Council (Appendix C) and program faculty (Appendix D) are further networking resources for you.

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Once you have a master list of companies to pursue, rank the companies, and focus your efforts initially only on the top 10‐20. Check to make sure they accept interns, and if you are an international student, that the company will sponsor international workers. Find out if the company offers paid or unpaid internships and when their internships are available. Searching for an internship or job takes a lot of time, and it makes sense not to spread yourself too thin in the beginning. If none of your most sought after jobs work out, drop down to other choices. As you research and network, stay organized in your search by keeping a spreadsheet of all the companies you contact, when the contact was made and any resulting follow‐up, etc. needed. Please be aware that indiscriminately posting your resume on every biotech website out there will be a waste of your time.

Lastly, pay attention to my emails! I will be sending forward all internship and job announcements I receive from industry contacts plus educational and networking opportunities you won’t want to miss. Although this Handbook is designed to include all you’ll need to successfully complete BIOT 684, I anticipate that there may be changes in processes external to the program, which will require me to update the information periodically. Be sure to save all program emails in a folder for future reference.

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PAPERWORK REQUIREMENTS

Before you will be allowed to register for BIOT 684, you will need to complete two documents and return them to the program coordinator via email attachment: 1) the Internship Description Form (Appendix E); and 2) the PPiB Learning Agreement (Appendix F). The Internship Description Form contains basic information about the internship, such as job title and when and where the internship will take place, plus contact information for the student, mentor and company. We ask that you scan your offer letter and attach it to the same email as your Internship Description Form.

The PPiB Learning Agreement is a little more complicated. This document provides a listing of all the responsibilities of the various parties—the student, faculty advisor (committee chair), onsite supervisor, and program office—during the internship experience. Furthermore, it provides the nature of the goals of the internship, what we call the “learning objectives.” These are written as broad objectives with specific activities or tasks that will accomplish the objective. How your mentor will evaluate your goals, and deadlines for accomplishing the tasks, are written into the agreement. It is signed by all parties to the agreement and returned to the program coordinator. Like the Internship Description Form, it must be received by the program office before you will be allowed to register for BIOT 684.

Half‐way through, and at the conclusions of the internship, your site supervisor will complete an evaluation of your performance (See appendicesHandbook G and H). The intent of the evaluations is to provide the student with information that can be used to improve their work, and it also provides a basis for counseling and guidance of the student. Once you and your mentor have signed these evaluations, scan them and send as an email attachment to [email protected] and to your faculty advisor. Lastly, complete the Student Evaluation of Site (Appendix I). This feedback will ensure that only quality internship sites are offered to students.

In order to insure confidentiality of data and business initiatives, have your onsite supervisor preview the presentation you will make for your final exam. He or she should then complete the Confidentiality Memo (Appendix J) and return to the program office via email attachment. We need thisStudent on file before you present. Finally, you must submit a "Request and Announcement of Final Examination” by the semester deadline to the Office of Graduate Studies (http://ogs.tamu.edu/forms/faculty/ogsfinalrequest.pdf). The request must be received 10 working days before the exam.

International students have some additional paperwork. If the internship is paid, they will need to submit a Curricular Practical Training (CPT) form to International Student Services (ISS)PPiB (http://international.tamu.edu/iss/Webfile /Employment/CPT/CPT_Authorization_Form_2‐ 19‐09.pdf). If an international student is completing an internship in the fall or spring, they must apply for a full course waiver, either from the Registrar’s Office or ISS.

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Consult the Full Course Waiver Flow Chart to determine which is better to seek: http://international.tamu.edu/iss/Webfile/Immigration/ReducedCourseLoad/20090212074941 835.pdf. The F‐1 Reduced Course Load Form from ISS is at http://international.tamu.edu/iss/Webfile/Immigration/ReducedCourseLoad/F‐ 1_Reduced_Course_Load.pdf.

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WRITING LEARNING OBJECTIVES

Stating your learning objectives or goals for your internship experience formally is important because it requires you to examine what you know, what you hope to learn, and how the internship experience will contribute to your future career goals. It is a personal plan for you, but the process is no different than the planning that all successful companies and institutions employ. Thus, the process of delineating your learning objectives will give you valuable planning experience, and is one of the learning objectives of the Biotechnology Program.

In devising your learning objectives, you need to think first in terms of broad goals— such as improving your communication skills or learning a new, advanced molecular technique—and then in specific ways that can accomplish that goal. As in all real world, practical planning, you also need to consider how you will know you have accomplished the goal. That is, you must be able to measure the outcome of the specific activity. When you need to accomplish a goal is an essential aspect of the planning process; thus, you must set deadlines.

Once you have accepted an internship and have an idea of your employer’s needs, you will need to formulate your learning objectives to be inserted in the PPiB Learning Agreement. These learning objectives should incorporate the employer’s needs and also any personal growth objectives you have. Begin by sharing your ideas Handbookwith your faculty advisor. Your faculty advisor (committee chair) should be able to evaluate whether your goals are feasible for a 10 week internship, if they represent new or complementary activities for you, and whether you have written up the objectives properly. Some examples of properly written objectives are given below. Once you have discussed your objectives with your advisor, you need to run these by your site supervisor/mentor for their approval or further revision.

Some examples: Learning objective: Improvement of presentation skills Learning activity: Give a 15 minute PowerPoint presentation on the limitations of various cloning techniques to co‐workers Evaluation: StudentCo‐workers complete a presentation skills evaluation form; a summary of feedback is included in the portfolio along with the slides Deadline: End of semester

Learning objective: Improvement of written communication Learning activity: Create a 500 word article for the summer edition of the company newsletter Evaluation:PPiB The newsletter article is included in the portfolio Deadline: July 1st

Learning objective: Learn new technical skills Learning activity: Perform Real‐Time PCR on an at least 10 samples using an ABI 7700

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Evaluation: A detailed protocol for the procedure and results included in portfolio Deadline: 1 month into internship

Learning objective: Understand company organizational structure and function Learning activity: Interview at least one person in each division regarding the purpose of the division and its relationship to other divisions Evaluation: An explanation of functions and a diagram of company organization is included in the portfolio Deadline: 2 weeks into internship

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PROFESSIONAL PORTFOLIO GUIDELINES

The purpose of the portfolio assignment is to gather together in one place all of the accomplishments of your biotechnology career. Much of the portfolio consists of reflection on the skills and competencies you have obtained through coursework, informal learning experiences, and your internship. Having thought about and documented what you have done will be a tremendous help when you are in a job interview. For instance, you will quickly be able to detail times when you solved an ethical problem or worked productively as part of a team to solve a problem.

The PPiB has some specific content requirements for your portfolio. The Portfolio must contain a cover sheet, a table of contents (see Appendix K for an example), certain internship preparation documents, a section reflecting on biotechnology program coursework and professional competencies, another section reflecting on the internship experience itself, evaluations from the internship, and the PowerPoint presentation slides given at the final exam. The portfolio should be double‐spaced, in 10‐12 font, and with numbered pages. Do not include the Internship Description Form containing your UIN. Your portfolio will available for review by future students and others interested in our program.

Once you have completed all editing, send an electronic copy to all your committee members, or if they prefer, provide them with a CD. The Biotechnology program office requires a CD of your portfolio in a jewel case with a cover insert. HandbookYou may pick up blank CD‐R’s and jewel cases from the program coordinator. The CD cover should contain your name, your photo, “Professional Portfolio,” internship site, semester of internship, and the PPiB logo.

Internship Preparation Documents

The following items should be included: 1. Resume—2‐3 pages max; include educational background, honors or recognition achieved, work experience, special skills, membership in organizations or other relevant information. 2. References—provide a list of 3‐4 people that would be willing to provide a reference for you. These shouldStudent be people knowledgeable about you professionally and personally. Include all contact information. Examples would be your faculty advisor or other faculty you interacted with and former employers. 3. PPiB Learning Agreement—this is the agreement that lists the learning objectives for your internship PPiB

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Section 1—Reflection on Coursework and Competencies

You should thoughtfully reflect on your experiences in the biotechnology graduate program. First, chose 1‐3 examples of work developed in each course you have taken. Next, write a 3‐5 page essay reflecting on each class including: 1) a brief description of the class; 2) key class concepts learned and demonstrated by the work you selected; and 3) any additional learning you might need in this area. It is best to complete the reflection paper as soon as you complete the class, while the material is fresh in mind.

There are four competencies that the BIOT curriculum is designed to develop in our students. These competencies are essential for success in business and other professional endeavors. Upon graduation we expect that students should have acquired: 1) problem‐solving abilities; 2) teamwork skills; 3) communication skills; and 4) bioethics.

Problem‐solving abilities The ability to think through problems and come up with solutions is an important aspect of the work you will be doing. Think over your experiences that may have involved: • critical thinking—the ability to clearly analyze a problem or situation and make a logical, well‐informed choice • creative thinking—the ability to find innovative solutions to problems • consensus building—using techniques to enhance cooperation in a group • personal judgment—understanding the role of valuesHandbook and emotions in decision‐making

Teamwork skills The ability to work in a multidisciplinary team or group is critical in today’s workplace. Here are some ways you may have worked productively as a team: • collaborated on a project • served as a team leader • managed conflict in a team • motivated a team • delegated responsibility

Communication skills Student Excellent written and oral communication skills are highly sought after in employees. Think of some examples in your graduate study where you demonstrated: • effective speaking and listening • effective presentation of goals and ideas to an audience • effective use of technology and media • effective writing of letters, memos, reports or position papers PPiB• effective use of graphs, tables, or graphics to explain complex phenomena

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Bioethics This is a standard of conduct, or code of morals, for life science research. Think of times in your graduate study when you became aware of a controversial issue and its relationship to biotechnology. Are there limitations to the use of technology?

Just as you did with your coursework, pick 1‐3 examples of each competency acquired during your time in the biotechnology program and reflect on the experience in a short paper. Your examples here can be from any class, and also from student work and organizational experiences. For example, you might want to reflect on how you solved an ethical problem encountered as a teaching assistant, or how you organized and worked as a team on a Biotechnology Society project. In this section of the portfolio you may also reflect on any additional competency you acquired that you believe is a valuable skill in the marketplace.

Section 2—Reflection on Internship

Your reflection should begin with an introduction that describes the company or institution where you worked, and what your responsibilities were during the internship. Next examine each of your learning objectives and the activities associated with each goal. Describe the methods or procedures you used and the success or outcomes that followed. Provide the results of your experiments, the protocols you devised, or the newsletter article you produced. Discuss any limitations or failures to attain your goals. If applicable to your situation, you should analyze the accounting, finance, marketing, and managementHandbook principles you used or observed in action at your internship site. Also be sure to connect concepts learned in classes with your internship experience, and times when you used your teamwork, analytical, and communication skills or knowledge of bioethics. Lastly, critique you experience, consider any additional learning that would be helpful, and give your recommendations for future students interning at your site. Student PPiB

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BIOT 684 EVALUATION AND FINAL EXAM

BIOT 684

Your grade (S/U) for BIOT 684 will be awarded by your faculty advisor on the basis of satisfactory/unsatisfactory completion of the following: 1) portfolio section 2 as described in this handbook; 2) positive site supervisor evaluations; and 3) a PowerPoint presentation of your internship experience. Section 2 will be included in your complete portfolio, which will be the basis for your program final exam. The presentation created here is submitted to your supervisor to review for confidential material and will be given during the public portion of your final exam.

Program Final Exam

As you complete sections of your portfolio during the semester, send them to your faculty advisor for editing and revision comments. It is a good idea to discuss deadlines for drafts of the portfolio, which will aid in scheduling time for a thoughtful review of your portfolio and will contribute to a high quality portfolio and learning experience for you. The completed portfolio must be submitted in proper format to all committee members and the program coordinator one week prior to the final oral exam and portfolio presentation.

Creating the professional portfolio is time‐consuming.Handbook You will likely have other course and work responsibilities, plus you will be preparing for your final oral exam. Thus, it is highly recommended that you complete your reflections on coursework and program competencies (section one) soon after completion of the course or activity, and that you submit them to your faculty advisor for comment before the commencement of the internship. This kind of advance planning process is the best strategy to produce a high quality portfolio, a friendly committee, and the confidence to shine in a future job interview.

Following the public presentation of your internship experience, your committee will meet alone with you and question you about what you did, why you did it, why it did or didn’t work, and technical questions regarding your reagents, media, equipment, and so on. They may ask you about theStudent science and business principles applicable to your work. They may ask about coursework or competencies you discussed in your portfolio and their relationship to your internship. When the committee is satisfied they have enough information to make a decision, you will be excused while the committee decides. If all is satisfactory, the committee will sign off on the exam. If the committee feels you were unprepared and performed poorly, they can request a second examination.

PPiB

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Appendix B—BIOT Internship Sites

Company or Institution Location Ambion (now Applied Biosystems/Life Technologies) Austin, TX Aventis Crop Science Tianjin Office Tianjin, China Baylor College of Medicine Houston, TX Baylor College of Medicine- Office of Technology Administration Houston, TX BCR Environmental Jacksonville, FL BioHouston Houston, TX Brigham Women’s Hospital, HPCGG Microarray Cambridge, MA Central Texas Orthopedics Austin, TX DiaSorin, Inc. Stillwater, MN DPS Crime Lab Austin, TX Fort Worth Zoo Fort Worth, TX Geneftix San Diego, CA Genetic Savings & Clone College Station, TX GlaxoSmithKline King of Prussia, PA INCELL San Antonio, TX InforQuest Clinical Network, Inc. Burleson, TX Integrative Center for Homeland Security College Station, TX Lexicon Genetics The Woodlands, TX Lynntech College Station, TX MD Anderson Cancer Research Center Houston, TX Methodist Hospital HandbookHouston, TX Monsanto St. Louis, MO New England Biolabs Ipswitch, MA NSF Center for Integrated Pest Management Raleigh, NC Oral Reconstruction and Cosmetic Houston, TX Orchid Cellmark Dallas, TX ProdiGene, Inc College Station, TX Reactive Surfaces Limited Austin, TX Scott & White Memorial Hospital Temple, TX St. Jude Medical Center Alpharetta, GA Synergos, Inc The Woodlands, TX Synthecon Houston, TX TAMU Health Science CenterStudent College Station, TX TAMU System Office of Research College Station, TX TAMU System Office of Technology Commercialization College Station, TX TAMU-Biochemistry Dept. College Station, TX TAMU-Food Microbiology Lab College Station, TX TAMU-Food Protein R & D Center College Station, TX TAMU-Institute of Biosciences and Technology Houston, TX TAMU-Integrative Center for Homeland Security College Station, TX TAMU-LaboratoryPPiB for Plant Genome Technologies College Station, TX TAMU-National Center for Electron Beam Research College Station, TX TAMU-Poultry Science Dept. College Station, TX TAMU-The Veterinary Medical Diagnostic Lab College Station, TX TAMU-Toxicology Lab College Station, TX

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TAMU-Veterinary Anatomy & Public Health College Station, TX TAMU-Veterinary Physiology and Pharmacology College Station, TX TEEX, Technology & Economic Development Division College Station, TX Texas Agriculture Extension Service College Station, TX Univ. of Southern California-Zilka Neurogenetic Institute Los Angeles, CA Univ. of Kentucky-Center for Pharmaceutical Science & Technology Lexington, KY US Government Accountability Office Washington, D.C. USDA-Cotton Pathology College Station, TX USDA-Forest Service College Station, TX USDA-Southern Plains Agricultural Research Center College Station, TX UT Southwestern Medical Center Dallas, TX

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Appendix C—Program Advisory Council Updated 7/7 09

Chair Michael Dilling, Ph.D. Baylor Licensing Group Houston, TX 77030

Fuller Bazer, Ph.D. Texas A&M University College Station, TX 77843

Mr. Eloy Corona Monsanto Company St. Louis, MO 63167

Peter Schuerman, Ph.D. Texas A&M University College Station, TX 77843

Mimi Healy, Ph.D. Bacterial Barcodes, Inc., Handbook a wholly‐owned subsidiary of bioMerieux Athens, GA 30602

Mr. Bruce W. Leander Retired Biotech Executive Austin, TX 78749

Mr. Bill Lemons Kelly Scientific Resources Houston, TX 77040 Student Matthew Lorence, Ph.D., M.B.A. Tessarae, Inc. Potomac Falls, VA 20165

Ms. Pamela Mabry (formerly) Encysive Pharmaceuticals Houston,PPiB TX 77081

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Jason Moore, M.S., M.B.A. PLx Pharma, Inc. Houston, TX 77054

Mary Pat Moyer, Ph.D. INCELL Corporation, LLC San Antonio, TX 78249

Ms. Dalal Murgai Regulatory Outsource Consulting, Inc. The Woodlands, TX 77382

Oliver Murphy, Ph.D. Lynntech College Station, TX 77840

Steven Navran, Ph.D. Synthecon, Inc. Houston, TX 77054

Mr. Vijay Pillai, M.B.A. Oracle Corporation Handbook Reston, VA 20190

Sushil K. Sharma, Ph.D., D.P.H. U. S. Government Accountability Office Washington, DC 20548

Jim C. Williams, Ph.D. (formerly) Opexa Therapeutics, Inc. The Woodlands, TX 77381 Student PPiB

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Appendix D—Program Faculty

Last name First name e‐mail address College Dept Microbial & Molecular Alaniz Robert [email protected] TAMUHSC Pathogenesis Aramayo Rodolfo [email protected] Science Biology Ball Judy [email protected] Vet Med Vet Pathobiology Berghman Luc luc‐r‐[email protected] Agriculture Poultry Science Blackwell David [email protected] Mays Finance Buenger Victoria [email protected] Mays Management Burghardt Robert [email protected] Vet Med Vet Integrative Biosciences Chapkin Robert S. r‐[email protected] Agriculture Nutrition & Food Science Cheng Zhengdong [email protected] Engineering Chemical Engineering Coates Craig c‐[email protected] Agriculture Entomology Cothran Gus [email protected] Vet Med Vet Integrative Biosciences Cudd Timothy [email protected] Vet Med Vet Physiology & Pharmacology Defigueiredo Paul [email protected] Agriculture Plant Pathology & Microbiology Derr James [email protected] Vet Med Vet Pathobiology Dunne Patrick [email protected] Vet Med Vet Integrative Biosciences Faridi Nurul [email protected] Agriculture Ecosystem Science & Management Funkhouser Ed ed‐[email protected] HandbookAgriculture Biochemistry & Biophysics Gastel Barbara b‐[email protected] Vet Med Vet Integrative Biosciences Gentry Terry [email protected] Agriculture Soil & Crop Sciences Gill Clare clare‐[email protected] Agriculture Animal Science Gould Jean [email protected] Agriculture Ecosystem Science & Management Grunlan Melissa A. [email protected] Engineering Biomedical Engineering Gunn Martyn [email protected] Agriculture Biochemistry & Biophysics Hahn Mariah S. [email protected] Engineering Chemical Engineering Hall Tim [email protected] Science Biology Han Arum [email protected] Engineering Electrical & Computer Engineering Hilty Christian [email protected] Science Chemistry Ing Nancy [email protected] Agriculture Animal Science Jayaraman Arul [email protected] Engineering Chemical Engineering Johnston Spencer [email protected] Agriculture Entomology Kao Katy [email protected] Engineering Chemical Engineering Liu Wenshe [email protected] Science Chemistry Loopstra Carol c‐[email protected] Agriculture Ecosystem Science & Management Magill PPiBClint c‐[email protected] Agriculture Plant Pathology & Microbiology Mullet John [email protected] Agriculture Biochemistry & Biophysics Ng Desmond [email protected] Agriculture Agricultural Economics Biological & Agricultural Nikolov Zivko [email protected] Engineering Engineering

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Park Bill [email protected] Agriculture Biochemistry & Biophysics Patterson C. O. [email protected] Science Biology Pillai Suresh [email protected] Agriculture Poultry Science Rathore Keerthi [email protected] Agriculture Soil & Crop Sciences Russell David [email protected] Science Chemistry Safe Steve [email protected] Vet Med Vet Physiology & Pharmacology Microbial & Molecular Samuel James [email protected] TAMUHSC Pathogenesis Sayes Christie [email protected] Vet Med Vet Physiology & Pharmacology Schwartz Cris [email protected] Engineering Mechanical Engineering Siegele Deborah d‐[email protected] Science Biology Skow Loren [email protected] Vet Med Vet Integrative Biosciences Stelly David [email protected] Agriculture Soil & Crop Sciences Sturino Joseph [email protected] Agriculture Nutrition & Food Science Thomas Terry [email protected] Science Biology Tiffany‐Castiglioni Evelyn [email protected] Vet Med Vet Integrative Biosciences Ugaz Victor M. [email protected] Engineering Chemical Engineering Welsh Jane [email protected] Vet Med Vet Integrative Biosciences Wild Jim j‐[email protected] Agriculture Biochemistry & Biophysics Wood Thomas [email protected] Engineering Chemical Engineering Young Colin [email protected] HandbookVet Med Vet Integrative Biosciences Yuan Joshua [email protected] Agriculture Plant Pathology & Microbiology Zhang Hongbin [email protected] Agriculture Soil & Crop Sciences Zhou Huaijun [email protected] Agriculture Poultry Science Zhu‐Salzman Keyan [email protected] Agriculture Entomology

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Appendix E—Internship Description Form

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Texas A&M University Professional Program in Biotechnology Internship Description Form

Student Name: UIN: Internship semester: Internship address: Mobile phone: e‐mail address:

Company Name: Address 1: Address 2: City, state, zip code: Web address: Telephone: Handbook Fax:

Supervisor Name: Title: Telephone: e‐mail:

Internship Dates: Position title: Student Position description: Salary:

Please complete the required information in the second column of the form. As you type in the table it will enlarge the cell to fit the contents. Save your document and send as an e‐mail attachment to [email protected]. Also attachPPiB a copy of your internship offer letter.

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Appendix F—Learning Agreement

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Texas A&M University Professional Program in Biotechnology Learning Agreement

This agreement between (insert student and company names) and the Texas A&M Professional Program in Biotechnology provides a listing of responsibilities of the various parties involved and the specific learning objectives or goals of the student during the internship experience.

RESPONSIBILITIES UNDER THIS AGREEMENT: Faculty Advisor (Committee Chair): • Help formulate the student’s learning objectives. • Meet with the student to provide guidance and support prior to the internship. • Assess the student’s learning based on predetermined objectives and evaluation criteria outlined in the BIOT 684 syllabus. • Provide telephone and e‐mail follow‐up as needed throughout the internship to provide guidance and support.

Site Supervisor: • Help formulate the student’s learning objectives. • Provide direction to help the student achieve the learningHandbook objectives. • Complete a midterm and final evaluation of the student and return forms to the PPiB Office. • Assume responsibility for the student’s supervision during the internship. • Review student presentation for confidential material and send memo to PPiB Office.

Student: • Register for credit after completing pre‐registration conference with your faculty advisor. • Provide a completed and signed Learning Agreement by the end of the second week of the internship to the PPiB Office. • Perform the tasksStudent and responsibilities assigned by your site supervisor. • Follow the rules and regulations of the business or agency. • Consult with your faculty advisor regarding any changes or problems that arise during your internship experience. • Complete the Student Evaluation of Site form and return to the PPiB Office.

Professional Program in Biotechnology Office: PPiB• Act as a liaison for the university, work site, faculty advisor, and student. • Assist faculty advisor, site supervisor, and student with any difficulties.

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LEARNING OBJECTIVES: (Insert a list of the broad learning objectives you will achieve during your internship, including specific activities, due dates, and evaluation methods that will be used. Set realistic goals that can be documented.)

Handbook

Your signature means you have read and agreed to the responsibilities listed for your role in this Learning Agreement.

Student Intern ______Date: ______Student Site Supervisor ______Date: ______

Faculty Advisor ______Date: ______

Program Coordinator ______Date: ______

AfterPPiB obtaining the Faculty Advisor and Site Supervisor signatures, the student should e‐mail the PPiB Learning Agreement as a .pdf attachment to Marian Cothran, Program Coordinator, [email protected] to sign and distribute.

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Appendix G—Mid‐term Evaluation by Supervisor

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Mid‐term Site Supervisor Evaluation of Student

This is a formative evaluation because it is intended to provide information that the student can use to improve their work. The supervisor should evaluate and discuss the results with the student midway and at the conclusion of the internship. The evaluation provides a basis for counseling and guidance of the student.

Part I. Circle the number that reflects performance of the student in each work area. 5=excellent 4=very good 3=good 2=fair 1=poor

1. Dependability—completes tasks without 5 4 3 2 1 reminders, thorough, accepts responsibility 2. Interpersonal relationships—enjoys good rapport 5 4 3 2 1 with professional and support staff and other personnel 3. Self‐reliance—exhibits resourcefulness and ability 5 4 3 2 1 to seek answers based on similar experiences Handbook 4. Response to criticism—accepts guidance and 5 4 3 2 1 constructive criticism 5. Neatness—personal appearance is appropriate 5 4 3 2 1 for professional setting 6. Discreteness—poised; aware of what to say and 5 4 3 2 1 do in a professional setting 7. Organization of time—manages time well; on 5 4 3 2 1 time to work and meetings, meets deadlines, prompt 8. Work habits—orderly, precise, and careful; 5 4 3 2 1 organizes and plans workStudent in logical way 9. Ability utilization—takes initiative; hard worker; 5 4 3 2 1 consistently attempts to improve performance 10. Verbal communication—uses proper language; 5 4 3 2 1 easily understood by others; effectively communicates ideas

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Part II. Please comment on the following: 1. Student’s greatest strengths

2. Areas that need improvement

Handbook

Signatures Site Supervisor ______Date ______

Student intern ______Student Date ______

Please e‐mail the completed mid‐term and final evaluations of student work to the student’s faculty advisor and to the PPiB Coordinator, Marian Cothran, [email protected]. Thank you.

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Appendix H—Final Evaluation by Supervisor

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Final Site Supervisor Evaluation of Student

This is a formative evaluation because it is intended to provide information that the student can use to improve their work. The supervisor should evaluate and discuss the results with the student midway and at the conclusion of the internship. The evaluation provides a basis for counseling and guidance of the student.

Part I. Circle the number that reflects performance of the student in each work area. 5=excellent 4=very good 3=good 2=fair 1=poor

1. Dependability—completes tasks without 5 4 3 2 1 reminders, thorough, accepts responsibility 2. Interpersonal relationships—enjoys good rapport 5 4 3 2 1 with professional and support staff and other personnel 3. Self‐reliance—exhibits resourcefulness and ability 5 4 3 2 1 to seek answers based on similar experiences 4. Response to criticism—accepts guidance and 5 Handbook4 3 2 1 constructive criticism 5. Neatness—personal appearance is appropriate 5 4 3 2 1 for professional setting 6. Discreteness—poised; aware of what to say and 5 4 3 2 1 do in a professional setting 7. Organization of time—manages time well; on 5 4 3 2 1 time to work and meetings, meets deadlines, prompt 8. Work habits—orderly, precise, and careful; 5 4 3 2 1 organizes and plans work in logical way 9. Ability utilization—takesStudent initiative; hard worker; 5 4 3 2 1 consistently attempts to improve performance 10. Verbal communication—uses proper language; 5 4 3 2 1 easily understood by others; effectively communicates ideas

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Part II. Please comment on the following: 1. Student’s greatest strengths

2. Areas that need improvement

3. Describe any additional technical or business preparation prior to the internship that would have improved student’s work performance.

Handbook

4. Give any other recommendations that would improve the internship program administration or student experience.

5. Would you employ another Texas A&M University Biotechnology student?

6. Would you be willingStudent to mentor a student or share your work experiences in a seminar on campus?

Signatures Site Supervisor ______Date ______

Student intern ______Date ______PPiB Please e‐mail the completed mid‐term and final evaluations of student work to the student’s faculty advisor and to the PPiB Coordinator, Marian Cothran, [email protected]. Thank you.

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Appendix I—Student Evaluation of Site

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Student Evaluation of Site

Please complete this form in the final week of your internship by filling in the boxes below and highlighting the ranking of each question. We will use your feedback to ensure that only quality internship sites are offered to our students. Save the form and return as an email attachment to [email protected] at the completion of your internship. Thank you for your response.

Semester: Date: Student: Faculty Advisor: Onsite mentor: Organization/Company:

Please use the following rating system to answer questions:

1=Agree, 2=Neutral, 3=Disagree, 4=Not Applicable

A. My internship enhanced my confidence in a non‐academic setting. 1 2 3 4

B. The goals and objectives of my internship were sufficiently defined. 1 2 3 4

C. The tasks I performed during my internship closely related to the activities I planned to undertake. 1 2 3 4 Handbook

D. I was satisfied with the direction and motivation provided by my site mentor. 1 2 3 4

E. I would recommend this site to future students. 1 2 3 4

Any additional comments you would like to share?

Would you be willing to shareStudent the benefits of your internship experience with students currently attending Texas A&M University by participating in a panel presentation or other means of communication?

YES NO PPiB

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Appendix J—Confidentiality Memo

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MEMORANDUM

DATE:

TO: Program Coordinator, Texas A&M Biotechnology Program

FROM:

RE: Review of internship presentation

I have reviewed (student’s name) internship presentation and have found no material of a confidential nature.

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Appendix K—Sample Table of Contents

Internship Preparation Documents Resume References PPiB Learning Agreement Section 1. Reflection on Coursework and Professional Competencies Coursework BIOT 601—Biotechnology Principles and Techniques I BIOT 602—Biotechnology Principles and Techniques II BIOT 603—Applied Principles of Biotechnology BIOT 635—Molecular Biotechnology BIOT 645—Biotechnology Writing BIOT 681—Biotechnology Seminar ACCT 640—Accounting Concepts and Procedures I FINC 635—Financial Management for Non‐Business MKTG 621—Survey of Marketing MKTG 656—Marketing Communications Management MGMT 655—Survey of Management Professional Competencies Bioethics Handbook Communication Skills Problem‐solving Ability Teamwork Skills Section 2. Reflection on Internship Introduction—Company description and Responsibilities Learning Objective 1—Improvement of Presentation Skills Learning Objective 2—Improvement of Written Communication Learning Objective 3—Learn New Technical Skills Learning Objective 4—Understand Company Organization Business Principles Critique and RecommendationsStudent Internship Evaluations Mid‐term Evaluation by Supervisor Final Evaluation by Supervisor Student Site Evaluation Internship PowerPoint Presentation Slides

PPiB

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