Molecular Machines in the Spotlight
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Horizon Europe - EU Multiannual Financial Framework
30 November 2018 Dear Prime Minister / Chancellor / Taoiseach / President, Horizon Europe - EU Multiannual Financial Framework (a letter to Heads of State or Government, signed by Nobel Prize and other international award winners and CEOs and Chairmen of leading European companies) At the European Council meeting in December, European leaders will discuss the 2021-2027 EU Multiannual Financial Framework, including the budget to be assigned to Research and Innovation, mainly through the next framework programme Horizon Europe. On this occasion, we want to remind them of the economic impact and the tangible improvements to European citizens' lives that have been generated over the years by the EU framework programmes for Research and Innovation. We urge Europe’s Heads of State or Government to support or even to increase the investment in Horizon Europe. €120 billion was seen as the absolute minimum to make Europe a global frontrunner by the High Level Group set by the European Commission and chaired by Pascal Lamy. Indeed, EU-funded research had a decisive impact and positively contributed to various areas, such as avoiding unnecessary chemotherapy for breast cancer patients; opening the way to batteries and solar cells of the next generation; reducing aircraft emissions and noise; enhancing cybersecurity; qualifying the future impact of artificial intelligence on jobs; etc. European industry underlines that the EU framework programmes help companies to build up know-how, have access to the “state-of-the-art”, achieve synergies and critical mass, access highly skilled and talented people, and network with customers and suppliers. EU-funded research has made an immense contribution to creating and disseminating scientific knowledge indispensable for innovation to flourish. -
Feasibility and Preliminary Efficacy of the 'HEYMAN' Healthy Lifestyle Program for Young Men: a Pilot Randomised Controlled
Ashton et al. Nutrition Journal (2017) 16:2 DOI 10.1186/s12937-017-0227-8 RESEARCH Open Access Feasibility and preliminary efficacy of the ‘HEYMAN’ healthy lifestyle program for young men: a pilot randomised controlled trial Lee M. Ashton1, Philip J. Morgan2, Melinda J. Hutchesson1, Megan E. Rollo1 and Clare E. Collins1* Abstract Background: In young men, unhealthy lifestyle behaviours can be detrimental to their physical and/or mental health and set them on a negative health trajectory into adulthood. Despite this, there is a lack of evidence to guide development of effective health behaviour change interventions for young men. This study assessed the feasibility and preliminary efficacy of the ‘HEYMAN’ (Harnessing Ehealth to enhance Young men’s Mental health, Activity and Nutrition) healthy lifestyle program for young men. Methods: A pilot RCT with 50 young men aged 18–25 years randomised to the HEYMAN intervention (n = 26) or waitlist control (n = 24). HEYMAN was a 3-month intervention, targeted for young men to improve eating habits, activity levels and well-being. Intervention development was informed by a participatory research model (PRECEDE-PROCEED). Intervention components included eHealth support (website, wearable device, Facebook support group), face-to-face sessions (group and individual), a personalised food and nutrient report, home-based resistance training equipment and a portion control tool. Outcomes included: feasibility of research procedures (recruitment, randomisation, data collection and retention) and of intervention components. Generalized linear mixed models estimated the treatment effect at 3-months for the primary outcomes: pedometer steps/day, diet quality, well-being and several secondary outcomes. Results: A 7-week recruitment period was required to enrol 50 young men. -
Making an IMPACT in Nutrition MEDIA
23/09/2019 Making an IMPACT in Nutrition MEDIA Clare Collins Professor of Nutrition and Dietetics NHMRC Senior Research Fellow Director of Research, School of Health Sciences Priority Research Centre in Physical Activity and Nutrition Faculty of Health and Medicine The University of Newcastle @ProfCCollins The University of Newcastle | CRICOS Provider 00109J | www.newcastle.edu.au From shutterstock.com 1 ACKNOWLEDGEMENT TO COUNTRY I would like to acknowledge the Traditional Owners of the land on which we meet today, the Yugambeh People, and to pay my respects to Elders past and present. From shutterstock.com DAA National Conference 2019 | Prof Clare Collins | @ProfCCollins 2 1 23/09/2019 ACKNOWLEDGEMENTS • Grants: NHMRC, Australian research Council, Heart Foundation, Diabetes Australia Research Program • University of Newcastle, Hunter Medical Research Institute, Hunter Children’s Research Fund, John Hunter Hospital Charitable Trust • Coal & Allied, Meat and Livestock Australia, Innovation Connections, • nib foundation, Bill and Melinda Gates Foundation, • Rainbow Foundation, Greater Charitable Foundation, Medibank Charitable Trust , • Challenge Ltd, Rijk Zwaan, Lions Club, Coles Community Fund • Consultancies: Heart Foundation, Dietitians Association of Australia, Australian Broadcasting Corporation, SHINE Australia, SPHealth, Prima Health Solutions, Novo Nordisk, Quality Bakers, Sax Institute • Some of the eHealth tools presented have been created through Prof Collins’ research • The Australian Eating Survey is available commercially -
Design, Synthesis, Photochemical and Biological Evaluation of Novel Photoactive Molecular Switches
TESIS DOCTORAL Título Design, Synthesis, Photochemical and Biological Evaluation of Novel Photoactive Molecular Switches Autor/es David Martínez López Director/es Diego Sampedro Ruiz y Pedro José Campos García Facultad Facultad de Ciencia y Tecnología Titulación Departamento Química Curso Académico Design, Synthesis, Photochemical and Biological Evaluation of Novel Photoactive Molecular Switches, tesis doctoral de David Martínez López, dirigida por Diego Sampedro Ruiz y Pedro José Campos García (publicada por la Universidad de La Rioja), se difunde bajo una Licencia Creative Commons Reconocimiento-NoComercial- SinObraDerivada 3.0 Unported. ̉ Permisos que vayan más allá de lo cubierto por esta licencia pueden solicitarse a los titulares del copyright. © El autor © Universidad de La Rioja, Servicio de Publicaciones, 2019 publicaciones.unirioja.es E-mail: [email protected] Facultad de Ciencia y Tecnología Departamento de Química Área de Química Orgánica Grupo de Fotoquímica Orgánica TESIS DOCTORAL DESIGN, SYNTHESIS, PHOTOCHEMICAL AND BIOLOGICAL EVALUATION OF NOVEL PHOTOACTIVE MOLECULAR SWITCHES Memoria presentada en la Universidad de La Rioja para optar al grado de Doctor en Química por: David Martínez López Junio 2019 Facultad de Ciencia y Tecnología Departamento de Química Área de Química Orgánica Grupo de Fotoquímica Orgánica D. DIEGO SAMPEDRO RUIZ, Profesor Titular de Química Orgánica del Departamento de Química de la Universidad de La Rioja, y D. PEDRO JOSÉ CAMPOS GARCÍA, Catedrático de Química Orgánica del Departamento de Química de la Universidad de La Rioja. CERTIFICAN: Que la presente memoria, titulada “Design, synthesis, photochemical and biological evaluation of novel photoactive molecular switches”, ha sido realizada en el Departamento de Química de La Universidad de La Rioja bajo su dirección por el Licenciado en Química D. -
Abstracts of the 43Rd Annual Scientific Meeting of the Nutrition Society of Australia
Meeting Report Abstracts of the 43rd Annual Scientific Meeting of the Nutrition Society of Australia Sandra Iuliano 1,*, Kirrilly Pursey 2, Rebecca Haslam 2 and Alison Coates 3 1 Department of Endocrinology, University of Melbourne/Austin Health, West Heidelberg 3081, Australia 2 School of Health Sciences, University of Newcastle, Callaghan 2308, Australia; [email protected] (K.P); [email protected] (R.H.) 3 School of Health Sciences, University of South Australia, Adelaide 5001, Australia; [email protected] * Correspondence: [email protected]; Tel.: +61-438-215-615 Received: 27 January 2020; Accepted: 7 February 2020; Published: 21 February 2020 Abstract: The 43rd Annual Scientific Meeting of the Nutrition Society of Australia was held in Newcastle, Australia, from 2 to 5 December 2019. The theme of the meeting was Nutrition: The Epicentre of Health. Abstracts were submitted from 24 countries. The conference was attended by 250 registrants and 208 papers were presented consisting of 16 plenary, 91 oral and 101 poster presentations. This issue presents the proceedings of this meeting in the form of abstracts of papers presented at the conference. Keywords: ageing; agriculture and farming; chronic diseases; communication and education; food security; genomics; gut microbiota; micronutrients; nutrition; public health 1. Plenary Presentations 1.1. Sustainability Implications of Different Food Production Systems Mario Herrero Commonwealth Scientific and Industrial Research Organisation, Brisbane, Australia Our food system, while providing food for billions of people, is currently malnourishing us. It directly affects one in three people around the world, causing stunting, wasting or obesity. The way in which we currently produce food is having substantial negative impacts on the environment in many parts of the world, and is trespassing several planetary boundaries. -
Is Skin Coloration Measured by Reflectance Spectroscopy Related to Intake of Nutrient-Dense Foods?
nutrients Article Is Skin Coloration Measured by Reflectance Spectroscopy Related to Intake of Nutrient-Dense Foods? A Cross-Sectional Evaluation in Australian Young Adults Lee M. Ashton 1,2, Kristine B. Pezdirc 1,2, Melinda J. Hutchesson 1,2 ID , Megan E. Rollo 1,2 and Clare E. Collins 1,2,* 1 School of Health Sciences, Faculty of Health and Medicine, University of Newcastle, Callaghan 2308, Australia; [email protected] (L.M.A.); [email protected] (K.B.P.); [email protected] (M.J.H.); [email protected] (M.E.R.) 2 Priority Research Centre in Physical Activity and Nutrition, University of Newcastle, Callaghan 2308, Australia * Correspondence: [email protected]; Tel.: +61-2-4921-5646 Received: 10 November 2017; Accepted: 20 December 2017; Published: 23 December 2017 Abstract: The current study examines associations between the dietary intakes of nutrient-dense foods, measured using brief indices and skin coloration, measured using reflectance spectroscopy in young adults. This is a cross-sectional analysis of 148 young Australian males and females (55% female) aged 18 to 25 years. Dietary intake was assessed using a validated food frequency questionnaire, with responses used to calculate two dietary indices: (i) the Australian Recommended Food Score (ARFS); and (ii) the Fruit And Vegetable VAriety Score (FAVVA). Skin yellowness was measured at three body locations using reflectance spectroscopy. Associations were assessed using Spearman’s correlation coefficients, regression analysis, and agreement using weighted kappa (Kw). Significant, moderate correlations were found between skin yellowness and diet index scores for the ARFS (ρ = 0.30, p < 0.001) and FAVVA score (ρ = 0.39, p < 0.001). -
Malnutrition Is Everybody's Business
Mon 4th - Fri 8th Oct 2021 TOOLKIT Malnutrition is everybody’s business Help fight malnutrition by getting involved and raising awareness INSIDE THIS TOOLKIT: • What is Malnutrition Week ANZ? • How can I get involved? • Ideas for events and activities • List of FREE resources www.dietitianconnection.com/malnutritionweekanz2021/ Supported by What is Malnutrition Week ANZ? Up to 40% of hospital patients1 and up to 50% of nursing home residents2 are thought to be malnourished. Part of the challenge is awareness, both amongst clinicians and the public. Malnutrition Week ANZ is a dedicated time to bring attention to the staggering rates of malnutrition in Australian and New Zealand communities and healthcare settings. It is your opportunity to band together with your nutrition colleagues to get involved and raise awareness of the important and necessary work being done in the malnutrition space. Start the conversation with your multidisciplinary health care colleagues and spread the word: malnutrition impacts lives. We need to make a difference. In 2021, Dietitian Connection wants to continue the fight against malnutrition, and we want you to play a part. Malnutrition is everybody’s business Our theme for 2021 is Malnutrition is everybody’s business. The campaign spotlights the shared responsibility of healthcare staff, families and patients to identify, treat and prevent malnutrition. 1. Australian Commission on Safety and Quality in Health Care 2018. Hospital-Acquired Complication: MALNUTRITION. https://www.safetyandquality.gov.au/sites/default/files/ migrated/SAQ7730_HAC_Malnutrition_LongV2.pdf 2. Dietitians Australia 2019. Royal Commission into Aged Care Quality and Safety. https://dietitiansaustralia.org.au/wp-content/uploads/2019/03/DAA_Royal-Commission-Aged- Care_Mar-2019_Final.pdf #MalnutritionWeekANZ Supported by How can I get involved? FREE It’s easy! The more people talking about malnutrition, RESOURCES the louder the message. -
The Molecular Monorail
RADBOUD UNIVERSITY NIJMEGEN RESEARCH PROPOSAL HONOURS ACADEMY FNWI The molecular monorail Authors: Robert BECKER Nadia ERKAMP Supervisor: Marieke GLAZENBURG Prof. Thomas BOLTJE Evert-Jan HEKKELMAN Lisanne SELLIES May 2017 Contents 1 Details 2 1.1 Applicants . .2 1.2 Supervisor . .2 1.3 Keywords . .2 1.4 Field of research . .2 2 Summaries 3 2.1 Scientific summary . .3 2.2 Public summary . .3 2.3 Samenvatting voor algemeen publiek . .3 3 Introduction 5 4 Background 8 4.1 The Feringa motor . .8 4.2 The ring molecule . .9 4.3 Threading of the track . 11 4.4 The track polymer . 12 5 Methods 14 5.1 Optical trapping . 14 5.2 Detection . 15 5.3 Synthesis . 16 5.3.1 Ring.................................... 16 5.3.2 Track . 17 6 Future applications 18 6.1 Further shrink down lab-on-a-chip approach . 18 6.2 Lab-on-a-chip approach in health care: Point-of-care testing (POCT) . 18 1 1 Details 1.1 Applicants Robert Becker - Biology Evert-Jan Hekkelman - Physics & Nadia Erkamp - Chemistry Mathematics Marieke Glazenburg - Physics Lisanne Sellies - Chemistry 1.2 Supervisor Name: Thomas Boltje Telephone: 024-3652331 Email: [email protected] Institute: Synthetic Organic Chemistry Radboud University Nijmegen 1.3 Keywords Nanomachine, Feringa, polymer, porphyrin, FRET 1.4 Field of research NWO division: Chemical Sciences [CW] Code Main field of research 13.20.00 Macromolecular chemistry, polymer chemistry Other fields of research 13.30.00 Organic chemistry 13.50.00 Physical chemistry 12.20.00 Nanophysics/technology 14.80.00 Nanotechnology 2 2 Summaries 2.1 Scientific summary In this proposal we present the design for a new kind of nanomachine. -
Dietary Patterns and Cardiovascular Disease Outcomes
Dietary Patterns and Cardiovascular Disease Outcomes An Evidence Check rapid review brokered by the Sax Institute for the National Heart Foundation of Australia. April 2017. An Evidence Check rapid review brokered by the Sax Institute for the National Heart Foundation of Australia. April 2017. This report was prepared by: Clare Collins, Tracy Burrows, Megan Rollo. University of Newcastle April 2017 © Sax Institute 2017 This work is copyright. It may be reproduced in whole or in part for study training purposes subject to the inclusions of an acknowledgement of the source. It may not be reproduced for commercial usage or sale. Reproduction for purposes other than those indicated above requires written permission from the copyright owners. Enquiries regarding this report may be directed to the: Manager Knowledge Exchange Program Sax Institute www.saxinstitute.org.au [email protected] Phone: +61 2 91889500 Suggested Citation: Collins C, Burrows T, Rollo M. Dietary Patterns and Cardiovascular Disease Outcomes: an Evidence Check rapid review brokered by the Sax Institute (www.saxinstitute.org.au) for the National Heart Foundation of Australia, 2017. Disclaimer: This Evidence Check Review was produced using the Evidence Check methodology in response to specific questions from the commissioning agency. It is not necessarily a comprehensive review of all literature relating to the topic area. It was current at the time of production (but not necessarily at the time of publication). It is reproduced for general information and third parties rely upon it at their own risk. Dietary Patterns and Cardiovascular Disease Outcomes An Evidence Check rapid review brokered by the Sax Institute for the National Heart Foundation. -
Food Addiction in Young Australian Adults
The neurobiology of eating behaviour: An investigation into the construct of food addiction in young Australian adults Kirrilly Maree Pursey, B. Nut & Diet, Hons class 1, University medal A thesis submitted for the degree of Doctor of Philosophy Nutrition and Dietetics University of Newcastle, NSW, Australia March 2016 Statement of originality This thesis contains no material which has been accepted for the award of any other degree or diploma in any university or other tertiary institution and, to the best of my knowledge and belief, contains no material previously published or written by another person, except where due reference has been made in the text. I give consent to this copy of my thesis, when deposited in the University Library, being made available for loan and photocopying subject to the provisions of the Copyright Act 1968. ……………………………………………… Kirrilly M Pursey ii Copyright permission I warrant that I have obtained, where necessary, permission from the copyright owners to use any of my own published work (i.e. journal publications) in which the copyright is held by another party. ……………………………………………… Kirrilly M Pursey iii Acknowledgement of collaboration I hereby certify that the work embodied in this thesis has been done in collaboration with other researchers. I have included as part of my thesis a statement clearly outlining the extent of the collaboration, with whom and under what auspices. ……………………………………………… Kirrilly M Pursey iv Acknowledgement of authorship I hereby certify that the work embodied in this thesis contains published papers/scholarly work of which I am a joint author. I have included as part of the thesis a written statement, endorsed by my supervisor, attesting to my contribution to the joint publications/scholarly work. -
Molecular Machines
Synthetic small molecules as machines: a chemistry perspective Professor Pradyut Ghosh Department of Inorganic Chemistry Indian Association for the Cultivation of Science 2A & 2B Raja S. C. Mullick Road, Kolkata 700032 E-mail: [email protected] 28th Mid-Year Meeting of Indian Academy of Sciences (IASc), Bengaluru, 1st July 2017 Feynman’s Dream on Molecular Machines Classic Talk given at the Meeting of the American Society of Physics in 1959 about the future of design and engineering at the molecular level The possibility of building small machines from atoms i.e. machines small enough to manufacture objects with atomic precision. Transcript of Talk : Caltech Eng. Sci. 1960, 23:5, 22–36. Feynman’s 1984 Visionary Lecture……. How small can you make machinery? Machines with dimensions on the nanometre scale. These already existed in nature. He gave bacterial flagella, corkscrew-shaped macromolecules as an example. Future vision – molecular machines will exist within 25–30 years. The aim of the lecture: To inspire the researchers in the audience, to get them to test the limits of what they believed possible. What neither Feynman, nor the researchers in the audience, knew at the time was that the first step towards molecular machinery had already been taken, but in a rather different way to that predicted by Feynman. What is that? 1953: Mechanical Bonds in Molecules Mid-20th century: Chemists were trying to build molecular chains in which ring-shaped molecules were linked together. The dream: To create mechanical bonds, where molecules are interlocked without the atoms interacting directly with each other. Frisch, H. -
How Molecules Became Machines
THE NOBEL PRIZE IN CHEMISTRY 2016 POPULAR SCIENCE BACKGROUND How molecules became machines The Nobel Prize in Chemistry 2016 is awarded to Jean-Pierre Sauvage, Sir J. Fraser Stoddart and Bernard L. Feringa for their development of molecular machines that are a thousand times thinner than a hair strand. This is the story of how they succeeded in linking molecules together to design everything from a tiny lift to motors and miniscule muscles. How small can you make machinery? This is the question that Nobel Laureate Richard Feynman, famed for his 1950s’ predictions of developments in nanotechnology, posed at the start of a visionary lecture in 1984. Barefoot, and wearing a pink polo top and beige shorts, he turned to the audience and said: “Now let us talk about the possibility of making machines with movable parts, which are very tiny.” He was convinced it was possible to build machines with dimensions on the nanometre scale. These already existed in nature. He gave bacterial flagella as an example, corkscrew-shaped macromole- cules which, when they spin, make bacteria move forward. But could humans – with their gigantic hands – build machines so small that you would need an electron microscope to see them? A vision of the future – molecular machines will exist within 25–30 years One possible way would be to build a pair of mechanical hands that are smaller than your own, which in turn build a pair of smaller hands, which build even smaller hands, and so on, until a pair of miniscule hands can build equally miniscule machinery.