groups Pro+1 Arg-3 Pro-2 Arg-2 Leu-5 MAPK13 CMGC 0.993 0.926 0.985 0.027 0.59 DYRK3 CMGC 0.994 0.925 0.963 0.726 0.044 CDKL5 CMGC 0.986 0.989 0.727 0.116 0.282 CDK14 CMGC 0.975 0.062 0.999 0.014 0.1 CDK1 CMGC 0.993 0.036 0.975 0.014 0.147 CDK4 CMGC 0.993 0.857 0.99 0.116 0.1 MAK CMGC 0.987 0.925 0.975 0.116 0.044 CDK11B CMGC 0.995 0.032 0.774 0.063 0.147 CDK2 CMGC 0.993 0.036 0.99 0.014 0.147 MAPK3 CMGC 0.985 0.237 0.985 0.063 0.044 MAPK1 CMGC 0.985 0.237 0.985 0.063 0.044 MAPK4 CMGC 0.993 0.722 0.985 0.044 0.17 MAPK8 CMGC 0.995 0.055 0.217 0.31 0.1 MAPK9 CMGC 0.996 0.055 0.217 0.31 0.1 CDK8 CMGC 0.995 0.886 0.965 0.044 0.223 CLK1 CMGC 0.847 0.925 0.594 0.861 0.044 GSK3A CMGC 0.994 0.262 0.837 0.088 0.044 GSK3B CMGC 0.994 0.262 0.837 0.088 0.044 CDK7 CMGC 0.996 0.722 0.985 0.056 0.087 CDK9 CMGC 0.995 0.722 0.965 0.044 0.17 MAPK12 CMGC 0.993 0.926 0.985 0.027 0.59 MAPK10 CMGC 0.995 0.055 0.217 0.31 0.1 CDK3 CMGC 0.993 0.036 0.99 0.014 0.147 CDKL1 CMGC 0.98 0.989 0.965 0.116 0.282 CDK6 CMGC 0.993 0.224 0.99 0.014 0.223 CDK5 CMGC 0.993 0.036 0.99 0.014 0.147 MAPK7 CMGC 0.986 0.131 0.615 0.063 0.17 DYRK1A CMGC 0.996 0.925 0.999 0.726 0.044 CDK13 CMGC 0.987 0.429 0.774 0.063 0.223 CDK10 CMGC 0.993 0.201 0.99 0.063 0.17 MAPK11 CMGC 0.98 0.097 0.945 0.063 0.17 MAPK14 CMGC 0.98 0.097 0.945 0.063 0.17 MAPK6 CMGC 0.993 0.722 0.985 0.044 0.17 CDKL4 CMGC 0.98 0.989 0.965 0.116 0.282 HIPK1 CMGC 0.994 0.925 0.925 0.469 0.044 CDK20 CMGC 0.986 0.722 0.615 0.044 0.17 HIPK4 CMGC 0.994 0.968 0.974 0.726 0.486 MAPK15 CMGC 0.986 0.097 0.889 0.063 0.17 DYRK2 CMGC 0.994 0.925 0.939 0.726 0.044 CDKL2 CMGC 0.929 0.989 0.937 0.116 0.282 CDK15 CMGC 0.94 0.224 0.937 0.014 0.17 CDK19 CMGC 0.995 0.886 0.965 0.044 0.223 HIPK2 CMGC 0.994 0.925 0.925 0.469 0.044

1 HIPK3 CMGC 0.994 0.925 0.925 0.469 0.044 CLK4 CMGC 0.847 0.925 0.594 0.861 0.044 DYRK4 CMGC 0.994 0.925 0.963 0.726 0.044 CDK12 CMGC 0.987 0.429 0.774 0.063 0.223 NLK CMGC 0.993 0.716 0.632 0.157 0.17 ICK CMGC 0.987 0.925 0.975 0.116 0.044 CDK11A CMGC 0.995 0.032 0.774 0.063 0.147 DYRK1B CMGC 0.996 0.925 0.999 0.726 0.044 SGK1 AGC 0 0.948 0.001 0.748 0.486 CHEK1 CAMK 0.005 0.943 0.113 0.164 0.924 AURKA Other 0 0.989 0.005 0.922 0.044 DCLK1 CAMK 0 0.931 0.008 0.485 0.924 DAPK3 CAMK 0 0.931 0.001 0.577 0.924 MAP3K7 TKL 0.008 0.951 0.472 0.773 0.044 PRKY AGC 0.001 0.943 0.003 0.748 0.486 NUAK1 CAMK 0 0.909 0.085 0.352 0.165 ROCK2 AGC 0 0.922 0.001 0.961 0.324 RPS6KA5 AGC 0 0.931 0.001 0.748 0.486 RPS6KA4 AGC 0.001 0.943 0.003 0.748 0.486 PAK3 STE 0.002 0.935 0.052 0.645 0.223 PAK4 STE 0.002 0.935 0.052 0.645 0.223 CHEK2 CAMK 0.001 0.931 0.041 0.485 0.924 RAF1 TKL 0 0.972 0.008 0.482 0.044 ARAF TKL 0 0.966 0.008 0.482 0.044 PIM1 CAMK 0 0.901 0.217 0.97 0.634 PSKH1 CAMK 0 0.931 0.001 0.577 0.924 BRAF TKL 0 0.972 0.008 0.482 0.044 PRKACA AGC 0 0.931 0.001 0.748 0.486 PRKACG AGC 0 0.931 0.001 0.748 0.486 PRKACB AGC 0 0.931 0.001 0.748 0.486 RPS6KB1 AGC 0 0.948 0.001 0.838 0.634 MARK3 CAMK 0 0.931 0.003 0.189 0.802 AKT1 AGC 0 0.931 0.001 0.748 0.486 AKT2 AGC 0 0.931 0.001 0.748 0.486 MAPKAPK2 CAMK 0.001 0.931 0.003 0.288 0.924 RPS6KA3 AGC 0.001 0.931 0.003 0.748 0.486 PRKX AGC 0.001 0.943 0.003 0.748 0.486 DAPK1 CAMK 0 0.931 0.001 0.577 0.924 PRKAA2 CAMK 0 0.931 0.001 0.062 0.924 HUNK CAMK 0 0.913 0.008 0.315 0.787 PRKAA1 CAMK 0 0.931 0.001 0.062 0.924 PAK1 STE 0.002 0.935 0.052 0.645 0.223 PAK2 STE 0.002 0.935 0.052 0.645 0.223 ROCK1 AGC 0 0.922 0.001 0.961 0.324 CAMK2B CAMK 0 0.931 0.001 0.13 0.924 CAMK2G CAMK 0 0.931 0.001 0.13 0.924 CAMK2D CAMK 0 0.931 0.001 0.13 0.924 CAMK1 CAMK 0 0.931 0.001 0.13 0.924 MELK CAMK 0 0.943 0.008 0.46 0.988 RPS6KA2 AGC 0.001 0.931 0.003 0.748 0.486 RPS6KA1 AGC 0.001 0.931 0.003 0.748 0.486 MYLK CAMK 0 0.931 0.001 0.577 0.924 CAMK4 CAMK 0 0.943 0.001 0.13 0.924 MAPKAPK3 CAMK 0.001 0.931 0.003 0.288 0.924 MYLK3 CAMK 0 0.931 0.001 0.82 0.924 PNCK CAMK 0 0.931 0.001 0.13 0.924 MARK2 CAMK 0 0.931 0.003 0.189 0.802 MYLK4 CAMK 0 0.931 0.001 0.82 0.924 CAMK1D CAMK 0 0.931 0.001 0.13 0.924 MAPKAPK5 CAMK 0.003 0.931 0.003 0.268 0.988 BRSK2 CAMK 0.001 0.931 0.064 0.579 0.924 NIM1K CAMK 0 0.931 0.003 0.575 0.924 DCLK2 CAMK 0 0.931 0.008 0.485 0.924 MYO3A STE 0.002 0.921 0.141 0.545 0.223 BRSK1 CAMK 0.001 0.931 0.064 0.579 0.924 MYO3B STE 0.002 0.921 0.141 0.545 0.223 SGK3 AGC 0 0.948 0.001 0.748 0.486 AURKB Other 0 0.909 0.002 0.922 0.044 SGK494 Other 0.081 0.903 0.78 0.399 0.165 CAMK1G CAMK 0 0.931 0.001 0.13 0.924 TSSK3 CAMK 0 0.931 0.008 0.46 0.988 DCLK3 CAMK 0 0.931 0.008 0.485 0.924 NUAK2 CAMK 0 0.909 0.025 0.485 0.373 MYLK2 CAMK 0 0.931 0.001 0.82 0.924 SGK2 AGC 0 0.948 0.001 0.748 0.486 PAK6 STE 0.002 0.935 0.052 0.645 0.223 SNRK CAMK 0.001 0.931 0.041 0.759 0.924 MAP3K20 STE 0.008 0.963 0.732 0.593 0.044 MARK1 CAMK 0 0.931 0.003 0.189 0.802 PAK5 STE 0.002 0.935 0.052 0.645 0.223 RPS6KB2 AGC 0 0.948 0.001 0.838 0.634 DAPK2 CAMK 0 0.931 0.001 0.577 0.924 RPS6KA6 AGC 0.001 0.931 0.003 0.748 0.486 AURKC Other 0 0.909 0.002 0.922 0.044 CAMK2A CAMK 0 0.931 0.001 0.13 0.924 AKT3 AGC 0 0.931 0.001 0.748 0.486 SIK3 CAMK 0 0.931 0.003 0.268 0.988 CLK2 CMGC 0.743 0.968 0.328 0.861 0.486 CLK3 CMGC 0.652 0.968 0.449 0.861 0.486 SRPK2 CMGC 0.075 0.989 0.178 0.407 0.282 CDKL3 CMGC 0.781 0.989 0.864 0.116 0.282 SRPK1 CMGC 0.075 0.989 0.178 0.407 0.282 SRPK3 CMGC 0.075 0.989 0.178 0.407 0.282 MOK CMGC 0.346 0.925 0.352 0.116 0.044 MAP2K7 STE 0.024 0.079 0.996 0.512 0.17 RIPK4 TKL 0.008 0.023 0.97 0.526 0.551 MAP3K12 TKL 0.008 0.896 0.979 0.773 0.044 ACVR1C TKL 0.008 0.498 0.974 0.735 0.044 PRKCG AGC 0 0.871 0.001 0.961 0.223 PRKCB AGC 0 0.871 0.001 0.961 0.223 PRKCA AGC 0 0.871 0.001 0.961 0.223 PRKCH AGC 0 0.871 0.001 0.961 0.223 PRKCE AGC 0 0.871 0.001 0.961 0.223 PRKCQ AGC 0 0.871 0.001 0.961 0.2233 PRKCD AGC 0 0.871 0.001 0.961 0.223 DMPK AGC 0 0.566 0.001 0.961 0.282 STK38 AGC 0 0.871 0.001 0.961 0.223 CDC42BPA AGC 0 0.566 0.001 0.961 0.282 CDC42BPG AGC 0 0.566 0.001 0.961 0.282 PIM3 CAMK 0 0.598 0.068 0.97 0.634 MASTL AGC 0.001 0.439 0.004 0.961 0.147 PIM2 CAMK 0 0.646 0.068 0.97 0.634 STK38L AGC 0 0.871 0.001 0.961 0.223 CDC42BPB AGC 0 0.566 0.001 0.961 0.282 KALRN CAMK 0 0.269 0.007 0.552 0.972 BUB1B Other 0.913 0.231 0.914 0.634 0.949 TRIO CAMK 0 0.525 0.03 0.552 0.972 STK17B CAMK 0 0.744 0.001 0.332 0.924 WEE2 Other 0.018 0.068 0.315 0.262 0.992 SIK1 CAMK 0 0.771 0.006 0.268 0.988 STK11 CAMK 0 0.104 0.217 0.399 0.949 SBK1 Other 0.001 0.598 0.146 0.575 0.924 VRK2 CK1 0.005 0.036 0.022 0.616 0.949 TSSK6 CAMK 0 0.181 0.068 0.46 0.972 SIK2 SIK 0 0.771 0.006 0.268 0.988 STK17A CAMK 0 0.703 0.001 0.118 0.988

4