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Home , Arizona State University, University of Michigan

DARYL R. KIPKE Department of Biomedical Email: [email protected] 2212 Lurie Biomedical Engineering Building Office: (734) 764-3716 1101 Beal Avenue Fax: (734) 786-0072 of URL: nelab.engin.umich.edu Ann Arbor, MI 48109-2099

EDUCATION 1991 Ph.D., Bioengineering , Ann Arbor, MI 1988 M.S.E., University of Michigan, Ann Arbor, MI 1986 M.Sc., Bioengineering University of Michigan, Ann Arbor, MI 1985 B.Sc., Engineering Science University of Michigan, Ann Arbor, MI

PROFESSIONAL EXPERIENCE 2001-present Associate Professor (tenured) University of Michigan, Ann Arbor, MI 1998-2001 Associate Professor (tenured) State University, Tempe, AZ 1992-1998 Assistant Professor , Tempe, AZ 1991-1992 Post-doctoral Research Fellow , Syracuse, NY 1991-1992 Adjunct Instructor Syracuse University, Syracuse, NY 1986-1991 Graduate Research Assistant University of Michigan, Ann Arbor, MI

Primary appointment in Department of Biomedical Engineering Member of Hearing, Balance, and Chemical Senses Program faculty Member of Neuroscience Program faculty

2001-pres. Principal Investigator, Neural Engineering Laboratory, University of Michigan 2003-pres. Director, National Center for Neural Communication , University of Michigan 2004-pres. Co-Founder and President/CEO, NeuroNexus , Inc., Ann Arbor, Michigan 2002-2006 Group leader for Biomedical Sensors and Subsystems, NSF Engineering Research Center for Wireless Integrated Microsystems, University of Michigan 2002-2006 Co-Founder and Chief Scientific Officer, Neural Intervention Technologies, Inc., Ann Arbor, Michigan. 2004-2006 Group leader for BioMEMS, NASA Bioscience and Engineering Institute, University of Michigan

AWARDS AND HONORS • National Institutes of Health FIRST award (1995) • National Science Foundation CAREER award (1995) • American Heart Association – Arizona Affiliate, Grant-in-Aid (1997) • U.S. delegate to U.S.-South Korea joint Bioengineering Symposium (1998) • Fellow, American Institute of Medical and Biological Engineering (2004) • Department Achievement Award, Department of Biomedical Engineering, University of Michigan (2005)

1 Daryl R. Kipke Vitae

• National Academies Keck Futures Initiative Conference Fellowship (2006)

RESEARCH AREAS • Implantable microscale neural interface devices for applications in neuroscience and functional • Neuroprostheses and brain-machine interface systems • Auditory neurophysiology and neural plasticity

PUBLICATIONS Peer-reviewed journal papers 1. Witte, R. S., P. J. Rousche, and D.R. Kipke, “Fast wave propagation in auditory cortex of an awake cat using a chronic microelectrode array”, Journal of Neural Engineering (In press) 2. Nunamaker, E. A., E. Purcell, and D.R. Kipke, “In vivo stability and biocompatibility of implanted calcium alginate disks”, Journal of Biomedical Materials Research: Part A (In press) 3. Johnson, M.D. O. Kao, and D.R. Kipke, “Spatiotemporal pH dynamics following insertion of neural microelectrode arrays”, Journal of Neuroscience Methods (In press, doi:10.1016/j.jneumeth.2006.09.023). 4. Marzullo, T.C. and C.R. Miller and D.R. Kipke, “Suitability of the cingulated cortex for neural control”, IEEE Transactions on Neural Systems and Rehabilitation, 14(4), pp 401-409, 2006. 5. Otto, K. J., M. D. Johnson, and D. R. Kipke, "Voltage pulses change neural interface properties and improve unit recordings with chronically implanted microelectrodes," IEEE Trans Biomed Eng, 53 (2), pp 333-340, 2006. 6. Ludwig, K. A., J. Uram, J. Yang, D. C. Martin, and D.R. Kipke, "Chronic recording performance of silicon microelectrode arrays with conductive polymer recording sites," J Neural Engin. 3 (1), pp. 59-70, 2006. 7. Subbaroyan, J., D.C. Martin, and D.R. Kipke, "A finite-element model of the mechanical effects of implantable microelectrodes in the cerebral cortex," J Neural Engin., 2:103-113, 2005 8. Williams, J.C., M. Holecko, S. P. Massia, P. J. Rousche, and D. R. Kipke, "Multi-site incorporation of bioactive matrices into MEMs-based neural probes," J Neural Engineering, 2, pp. L23-L28, 2005. 9. Gage, G. J., K. A. Ludwig, K. J. Otto, E. L. Ionides, and D. R. Kipke, "Naive coadaptive cortical control," J Neural Engineering, 2(2), pp 52-63, 2005. 10. Otto, K. J., P. J. Rousche, and Kipke D.R., "Best-frequency dependent behavior induced by cortical microstimulation in auditory cortex of rat," J Neural Engineering, 2(2), pp 42-51, 2005. 11. Johnson, M. D., K. J. Otto, and D. R. Kipke, "Repeated voltage biasing improves unit recordings by reducing resistive tissue impedances," IEEE Trans Neural Syst Rehabil Eng, 13(2), pp.160-165, 2005. 12. Otto, KJ, PJ Rousche, and DR Kipke, “Microstimulation in auditory cortex provides a substrate for detailed behaviors”, Hearing Research, 210(1-2), pp 112-117. 2005. 13. Becker, T. A., M. C. Preul, W. D. Bichard, D. R. Kipke, and C. G. McDougall, "Calcium alginate gel as a biocompatible material for endovascular AVM embolization: six-month results in an animal model," Neurosurgery, vol. 56, pp. 793-801, 2005 14. Witte, R.S. and Kipke, D. R., "Enhanced contrast sensitivity in auditory cortex as cats learn to discriminate sound frequencies," Cognitive Brain Research, vol. 22, pp. 171-184, 2005

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15. Vetter, R.J., J. C. Williams, J. F. Hetke, E. A. Nunamaker, and D.R. Kipke, "Spike recording performance of implanted chronic silicon-substrate microelectrode arrays in cerebral cortex," IEEE Trans Biomed Eng, (51) 6:896-904, 2004 16. Wise, K.D., D. J. Anderson, J. F. Hetke, D. R. Kipke, and K. Najafi, "Wireless implantable microsystems: High-density electronic interfaces to the nervous system," Proceedings of the IEEE, (92) 1:76-97, 2004. 17. Rathnasingham, R., S. C. Bledsoe, J. D. McLaren, and D. R. Kipke, "Characterization of implantable microfabricated fluid delivery devices," IEEE Trans. in Bio. Eng. 2004, 51(1): 138-145. 18. Kipke, D.R., R.J. Vetter, J.C. Williams, and J.F. Hetke, Silicon-substrate intracortical microelectrode arrays for long-term recording of neuronal spike activity in cerebral cortex. IEEE Trans Rehab. Engin, 2003. 11(2): 151-155. 19. Rousche, P.J., K.J. Otto, M.P. Reilly, and D.R. Kipke, Single-electrode intracortical micro-stimulation of rat auditory cortex: an evaluation of behavioral performance. Hearing Research, 2003. 179(1-2): p. 62- 71. 20. Becker, T.A., D.R. Kipke, M.C. Preul, W.D. Bichard, and C.G. McDougall, In vivo assessment of calcium alginate gel for endovascular embolization of a cerebral arteriovenous malformation model using the Swine rete mirabile. Neurosurgery, 2002. 51(2): p. 453-8; discussion 458-9. 21. Becker, T.A. and D.R. Kipke, Flow properties of liquid calcium alginate polymer injected through medical microcatheters for endovascular embolization. J Biomed Mater Res, 2002. 61(4): p. 533-40. 22. Clement, R.S, D.R. Kipke, and P. Carter (2002), “Measuring the electrical stapedius reflex with stapedius muscle EMG recordings ”, Annals of Biomedical Engineering, 30(2): 169-179. 23. Rousche, P.J., D. Pellinen, D. Pivin, J.C. Williams, R. Vetter, and D. R. Kipke (2001), “ ‘Flexible’ Polyimide-based intracortical electrode arrays with bioactive capability”. IEEE Trans. on Biomedical Engineering, 48(3):361-371. 24. Becker, T.A., D.R. Kipke, and T. Brandon (2001), “Calcium alginate gel: A biocompatible and mechanically stable polymer for endovascular embolization”, Journal of Biomedical Materials Research, 54, 76-86, 25. Williams, J.C., R.L. Rennaker, and D.R. Kipke (1999), “Long-term neural recording characteristics of wire microelectrode arrays implanted in cerebral cortex”, Brain Research Protocols, 4:303-313. 26. Clement, R.C., R.S. Witte, P.J. Rousche, and D.R. Kipke (1999), “Functional connectivity in auditory cortex using chronic, multichannel unit recordings”, Neurocomputing, 26-27:347-354. 27. Witte, R.S., K.J. Otto, J.C. Williams, and D.R. Kipke (1999), “Pursuing dynamic reorganization in auditory cortex using chronic, multichannel unit recordings in awake, behaving cats”, Neurocomputing, 26-27:593-600. 28. Williams, J.C., R.L. Rennaker, and D.R. Kipke (1999), “Stability of chronic multichannel neural recordings: Implications for a long-term neural interface”, Neurocomputing, 26-27:1069-1076. 29. Levy, K.L. and D.R. Kipke (1998). “Mechanisms underlying the cochlear nucleus octopus cell’s onset response: Synaptic effectiveness and spike threshold”. Journal of the Acoustical Society of America, 103(4):1940-1950. 30. Kipke, D.R. and Levy, K.L (1997). “Sensitivity of the cochlear nucleus octopus cell to synaptic and membrane properties: A modeling study”. Journal of the Acoustical Society of America, 102(1):391- 402. 31. Levy, K.L. and D.R. Kipke (1997). “A model of the cochlear nucleus octopus cell”. Journal of the Acoustical Society of America, 102(1):403-412.

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32. Kipke, D.R., B.M. Clopton, and D.J. Anderson (1991). “Shared-stimulus driving and connectivity in groups of neurons in the dorsal cochlear nucleus”, Hearing Research 55:24-38. In review 33. Seymour, J. P. and D. R. Kipke, “Biosensor design for reduced encapsulation in the CNS”, Journal of Biomaterials (in revision) 34. Nunamaker, E. A. and D. R. Kipke, “A hydrogel dura mater replacement for use with intracortical electrodes”, Journal of Neural Engineering (in revision)

PUBLICATIONS Book chapters or edited volumes 1. Rousche, P. J. and D. R. Kipke, "Next generation of cortical devices," in Neuroprosthetics: Theory and Practice, K. Horch and G. S. Dhillon, Eds. London: Imperial Press, 2004. 2. Kipke, D.R, D. S. Pellinen, and P. J. Rousche, "CNS recording electrodes and techniques," in Neuroprosthetics: Theory and Practice, K. Horch and G. S. Dhillon, Eds.: World Scientific Pub. Co., 2004. 3. Si, J., D.R. Kipke, S. Lin, A.B. Schwartz, and P.D. Perepelkin (1997). “Motor Cortical Information Processing” in Strategies in the Study of Biological Neural Networks (H. Eichenbaum and J.L. Davis, Editors). Wiley Press, New York. 4. Levy, K.L. and D.R. Kipke (1996). “A biologically-plausible model of neurons in the cochlear nucleus that computes accurate spike times for complex stimuli in real-time” in Computational Neuroscience (J. M. Bower, Ed.), Academic Press, San Diego, CA. pp. 101-106. 5. Kipke, D.R. and K.L. Levy (1995). “An application of neural speech processing in the cochlear nucleus to the estimation of fundamental frequency”. IEEE-EMBS Conf. Proceedings 6. Levy, K.L., and D.R. Kipke (1995). “The importance of membrane properties and synaptic location in octopus cells of the mammalian cochlear nucleus”, in The Neurobiology of Computation, (J. M. Bower, Ed.), Kluwer Academic Press, Boston, MA, pp. 93-99. 7. Peyton, S.F., and D.R. Kipke (1995), “A compartmental model of ventral cochlear nucleus cells: Responses to constant and amplitude-modulated tones”, in The Neurobiology of Computation, (J. M. Bower, Ed.), Kluwer Academic Press, MA, pp. 117-122. 8. Kipke, D.R., E. Herzog, and R.B. Barlow, Jr. (1993). “A computational model of the Limulus lateral eye on a parallel computer”, in Computations and Neural Systems, (J. Bower and F. Eeckman, Eds.), Kluwer Academic Press, Norwell, MA. Pp. 151-158.

PUBLICATIONS Conference abstracts and reviewed conference proceedings 1. J.P. Seymour and D.R. Kipke. “Fabrication of polymer neural probes with subcellular features for reduced tissue encapsulation,” Proceedings of the 28th International IEEE-EMBS Conference. (New York City, NY), pp. 4606-4609, August 2006. 2. Marzullo, T.C., H. Parikh, E. Kim, and D.R. Kipke. “ Analysis of field potentials during neuroprosthetic tasks using spikes as the control signal,” Society for Neuroscience Abstracts. (Atlanta, GA), October 2006. 3. J.P. Seymour and D.R. Kipke. “Ultra-fine structures on neural probes reduce cellular encapsulation,” Society for Neuroscience Abstracts. (Atlanta, GA), October 2006.

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4. Subbaroyan, J., K. Pennington and D.R. Kipke, "Chronic Tissue Response Induced By Flexible Polymer Interconnects at The Electrode-Tissue Interface", MRS Spring Meeting, San Francisco, CA, Apr. 17-21, 2006. 5. Subbaroyan, J. and D.R. Kipke, "The role of flexible polymer interconnects in chronic tissue response evoked by intracortical microelectrodes - a modeling and an in vivo study", 28th Annual International Conference of the Engineering in and Biology Society, New York, NY, Aug. 30 - Sep. 3, 2006. 6. Subbaroyan. J, Yoshida. T.D.K and Kipke. D.R., "Chronic tissue response evoked by variably flexible intracortical polymer implant systems", Selected to be presented at the Society for Neuroscience, 36th Annual meeting, Atlanta, GA, Oct. 14-18, 2006. 7. Lehmkuhle, M.J., and D.R. Kipke. “Neuromodulation of the ventromedial hypothalamus of the rat through deep brain stimulation”. Soc. Neurosci. Abs. 566.10, 2006. 8. Lehmkuhle, M.J., and D.R. Kipke. “Long-term neuromodulation of the ventromedial hypothalamus effects weight gain in the rat”. Biomed. Engin. Soc. Abs., 2006. 9. Lehmkuhle, M.J., and D.R. Kipke. “Neuromodulation of the ventromedial hypothalamus of the rat through deep brain stimulation effects animal weight”. Neural Interfaces Workshop, 2006. 10. Lehmkuhle, M.J., Butson, C.R., McIntyre, C.C., and D.R. Kipke. “Volume of cortical activation as a function of electrical stimulation configuration, duration, and amplitude in auditory cortex.” International Workshop on Neural Interface Technologies and Applications Abs., 2006 11. Lehmkuhle, M.J., Vetter, R.J., Parikh, H., Carrier, J.C., and D.R. Kipke. “Implantable Neural Interfaces for Characterizing Population Responses to Odorants and Electrical Stimuli in the Nurse Shark, Ginglymostoma cirratum.” AChemS Abs., 2006. 12. M.D. Gibson, M.D. Johnson, D.R. Dipke, "Neural biosensor probes for simultaneous in vivo detection of choline and electrophysiological activity in rat cortex", Program No. 835.2. 2006 Abstract Viewer/Itinerary Planner. Atlanta, GA: Society for Neuroscience, 2006. Online. 13. M.D. Johnson, D.R. Kipke, "Heterogeneous dopamine efflux and local field potential activity in dorsal striatum", Program No. 56.13. Abstract Viewer/Itinerary Planner. Atlanta, GA: Society for Neuroscience, 2006. Online. 14. M.D. Johnson, M.D. Gibson, L.G. Salas, R.K. Franklin, R.B. Brown, D.R. Kipke, "Spatiotemporal neurochemical and electrophysiological recordings in rodents", NINDS: 2006 Neural Interfaces Workshop, Bethesda, MD. 15. Johnson MD, Langhals NB, and Kipke DR, “Neural interface dynamics following insertion of hydrous iridium oxide microelectrode arrays”, IEEE-EMBS Conference, New York, NY. 9/1/2006 2006. 16. Lempka SF, Johnson MD, Barnett DW, Moffitt MA, Otto KJ, Kipke DR, and McIntyre CC, “Optimization of microelectrode design for cortical recording based on thermal noise considerations”, IEEE-EMBS Conference, New York, NY. 9/1/2006 2006. 17. R.J. Vetter, J.P. Seymour, R.M. Miriani, M. Velliste, G.W. Fraser, M.Wu, J.F. Hetke, D.R. Kipke, “A modular multiprobe cortical neuroprostheses”, Program No. 148.17/L6. 2006 Abstract Viewer/Itinerary Planner. Atlanta, GA: Society for Neuroscience, 2006. Online. 18. T, Pellinen DS, Purcell EK, Seymour JP and Kipke DR, "Local Drug Delivery System for Dynamic Control of Neural Environment using Parylene-Based Microelectrodes" Proceedings of the World Congress on Medical Physics and Biomedical Engineering 2006, Seoul, Korea, Aug 28-Sep 1, 3409-3412, 2006

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19. T. Moon, D. S. Pellinen, E. K. Purcell, J. P. Seymour, D. R. Kipke, "Local drug delivery system for dynamic control of neural environment using parylene-based microelectrodes", Program No. 835.13. 2006 Abstract Viewer/Itinerary Planner. Atlanta, GA: Society for Neuroscience, 2006. Online. 20. G.J. Gage, C. Kawahara, S.E. Ross, T.C. Marzullo, and D.R. Kipke, “Laminar Analysis of Movement Direction Information in Local Field Potentials of the Rat Motor Cortex”, Proc. of the 2006 IEEE Engin. In Medicine and Biology 28th Annual Conference, New York USA, Aug 30-Sep 3, 2006. 21. J. Lee, M.D. Johnson and D.R. Kipke, "Simultaneous neural Recording of spikes and LFPs", Biomedical Engineering Society 2006 Fall Meeting, Chicago, IL 22. J. Lee, R. Parikh and D.R. Kipke, "Wireless telemetry for micro intracortical neural interfaces", World Congress on Medical Physics and Biomedical Engineering 2006, Seoul, Korea 23. J. Lee and D.R. Kipke, "Neural processing with DWT in micro intracortical neural interface”, International Workshop on Microtechnologies in Medicine and Biology (MMB2006), Okinawa, Japan 24. T.C. Marzullo, J.R. Dudley, C.R. Miller, L.J. Trejo, D.R. Kipke, “Spikes, local field potentials, and electrocorticogram characterization in rats during motor learning and brain-machine interface tasks “, Program No. 707.9. 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2005. Online. 25. M.D. Johnson, R.K. Franklin, R.B. Brown, D.R. Kipke, “Neural probes for concurrently monitoring neurochemical and electrophysiological signals in vivo”, Program No. 569.15. 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2005. Online. 26. M.J. Lehmkuhle, C.R. Butson, C.C. McIntyre, D.R. Kipke, “Volume of cortical activation as a function of electrical stimulation configuration in auditory cortex”, Program No. 519.14. 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2005. Online. 27. G.J. Gage, S.E. Ross, and D.R. Kipke, “Layer-specific changes in motor cortex during motor skill learning”, Program No. 402.1. 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2005. Online. 28. D.R. Kipke, “Co-adaptive cortical control using multi-modal neural signals”, Biomedical Engineering Society 2005 Fall Meeting, Baltimore, Maryland (invited; presented by G. Gage). 29. J. Grotberg, M. O’Donnell, D.R. Kipke, L.K. McCauley, R.T. Larson, “The University of Michigan- NASA Bioscience and Engineering Institute”, Biomedical Engineering Society 2005 Fall Meeting, Baltimore, Maryland. 30. J. Seymour and D.R. Kipke, “Open- neural probes reduce cellular encapsulation”, Materials Research Society 2006 Spring Meeting, San Francisco, CA. 31. E. Purcell, J. Seymour, and D.R. Kipke, “A neural stem cell-seeded open-channel neural probe”, Materials Research Society 2006 Spring Meeting, San Francisco, CA. 32. E. Purcell and D.R. Kipke, "In vitro development and characterization of a cortical neural stem cell- seeded alginate scaffold", Society for Biomaterials 2006 Annual Meeting, Pittsburgh, Pennsylvania 33. E. Nunamaker, E. Purcell, and D.R. Kipke, "In vivo stability and encapsulation of subcutaneously implanted alginate disks", Society for Biomaterials 2006 Annual Meeting, Pittsburgh, Pennsylvania 34. R.J. Vetter, R.M. Miriani, B.E. Casey, K. Kong, J.F. Hetke and D.R. Kipke, ”Development of a microscale implantable neural interface (MINI) probe system”, Proc. of the 2005 IEEE Engin. In Medicine and Biology 27th Annual Conference, China, Sept 1-4, 2005. 35. G.J. Gage, E.L. Ionides and D.R. Kipke, ”Information capacity of brain machine interfaces”, Proc. of the 2005 IEEE Engin. In Medicine and Biology 27th Annual Conference, Shanghai China, Sept 1-4, 2005.

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36. T.C. Marzullo, J.R. Dudley, C.R. Miller, L. Trejo and D.R. Kipke, ”Spikes, local field potentials, and electrocorticogram characterization during motor learning in rats for brain machine interface tasks”, Proc. of the 2005 IEEE Engin. In Medicine and Biology 27th Annual Conference, Shanghai China, Sept 1-4, 2005. 37. M.D. Johnson, R.K. Franklin, K.A. Scott, R.B. Brown and D.R. Kipke, ”Neural probes for concurrent detection of neurochemical and electrophysiological signals in vivo”, Proc. of the 2005 IEEE Engin. In Medicine and Biology 27th Annual Conference, Shanghai China, Sept 1-4, 2005. 38. H. Parikh, T.C. Marzullo, G. Gage, and D.R. Kipke, ”Real-time detection of unitary events for cortical control”, Proc. of the 2005 IEEE Engin. In Medicine and Biology 27th Annual Conference, Shanghai China, Sept 1-4, 2005. 39. D.S. Pellinen, T. Moon, R.J. Vetter, R. Miriani, and D.R. Kipke, ”Multifunctional flexible parylene- based intracortical microelectrodes”, Proc. of the 2005 IEEE Engin. in Medicine and Biology 27th Annual Conference, Shanghai China, Sept 1-4, 2005. 40. K. A. Ludwig, J. Uram, J. Yang, and D. R. Kipke, “Chronic neural recordings using silicon microelectrode arrays electrochemically deposited with a conductive polymer,” NIH Neural Interfaces Workshop Abstracts (Bethesda, MD), November 2004. 41. K. J. Otto, M. D. Johnson, and D. R. Kipke, “Rejuvenation of chronically implanted neural probes,” Society for Neuroscience Abstracts (San Diego, CA), October 2004. 42. J. S. Seymour and D. R. Kipke, “Biodegradable polymers for short-term drug delivery on neural microelectrodes,” Society for Neuroscience Abstracts (San Diego, CA), October 2004. 43. J. Subbaroyan, E. Purcell, D. Martin and D. R. Kipke, “Characterization of the electrode-tissue interface in chronic neural implants,” Society for Neuroscience Abstracts (San Diego, CA), October 2004. 44. K. A. Ludwig, T. C. Marzullo, R. M. Miriani, N. B. Langhals, D. R. Kipke, “Generating a two dimensional control signal from motor and cingulate cortex using a novel adaptive filter paradigm,” Society for Neuroscience Abstracts (San Diego, CA), October 2004. 45. M. D. Johnson, K. J. Otto, J. C. Williams, and D. R. Kipke, “Bias voltages at microelectrodes change neural interface properties in vivo,” Proceedings of the 26th International IEEE-EMBS Conference (San Francisco, CA), pp. 4103-4106, September 2004. 46. G. J. Gage, K. J. Otto, K. A. Ludwig, and D. R. Kipke, “Co-adaptive Kalman filtering in a naïve rat cortical control task,” Proceedings of the 26th International IEEE-EMBS Conference (San Francisco, CA), pp. 4367-4370, September 2004. 47. D. R. Kipke, “Brain-machine interfaces using thin-film silicon microelectrode arrays,” (Invited), Proceedings of the 2004 International Symposium on Circuits and Systems (Vancouver, Canada), vol. 5, pp. V497-V499, May 2004. 48. Nunamaker, E.A., R. Rathnasingham, and D. R. Kipke, "Viscoelastic behavior of rat cortex in response to microscale-volume fluid injections," presented at 25th Annual Int'l Conf. IEEE Engin. in Medicine and Biol. Soc., Cancun, Mexico, 2003. 49. Moon, T., M. Ghovanloo, and D. R. Kipke, "Buckling Strength of Coated and Uncoated Silicon Microelectrodes," in 25th Annual Int'l Conf. IEEE Engin. in Medicine and Biol. Soc, Cancun, Mexico, 2003. 50. Johnson, M.J.,, J. C. Williams, and D. R. Kipke, "Chemical sensing capability of MEMS implantable multichannel neural microelectrode arrays," presented at 25th Annual Int'l Conf. IEEE Engin. in Medicine and Biol. Soc., Cancun, Mexico, 2003.

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51. T. A. Becker, D. R. Kipke, M. C. Preul, W. D. Bichard, and C. G. McDougall, "Chronic assessment of ALGEL® for endovascular embolization of an arteriovenous malformation model in swine," presented at 25th Annual International Conference of the IEEE/EMBS, Cancun, Mexico, 2003. 52. T. A. Becker and D. R. Kipke, "ALGEL® as a dural sealant: determination of effects on the sensori- motor cortex in rats," presented at 25th Annual International Conference of the IEEE/EMBS, Cancun, Mexico, 2003. 53. T. A. Becker, D. R. Kipke, and K. Brakora, "Endovascular embolization of aneurysms with ALGEL®: an in vitro study of delivery techniques and resulting gel stability," presented at 25th Annual International Conference of the IEEE/EMBS, Cancun, Mexico, 2003. 54. S. A. Nikles, D. S. Pellinen, D. R. Kipke, and K. Najafi, "Long term measurements of polyimide electrical characteristics for use in chronically implanted Neural Probes," presented at 25th Annual International Conference of the IEEE/EMBS, Cancun, Mexico, 2003. 55. K. J. Otto, P. J. Rousche, and D. R. Kipke, "The benefits of modular brain-machine interface system design," presented at presented at 25th Annual International Conference of the IEEE/EMBS, Cancun, Mexico, 2003. 56. R. J. Vetter, R. H. Olsson III, J. F. Hetke, J. C. Williams, D. Pellinen, K. D. Wise, and D. R. Kipke, "Silicon-substrate intracortical microelectrode arrays with integrated for chronic cortical recording," presented at 25th annual Intern. Conf. of the IEEE/EMBS, Cancun, Mexico, 2003. 57. Hetke, J.F., J.C. Williams, D.S. Pellinen, R.J. Vetter, and D.R. Kipke. 3-D silicon probe array with hybrid polymer interconnect for chronic cortical recording. in 1st International IEEE EMBS Conf. on Neural Engin. 2003. Capri, Italy: IEEE. p. 181-184 58. Otto, K.J., R.J. Vetter, T.C. Marzullo, and D.R. Kipke. Brain-machine interfaces in rat motor cortex: Implications of adaptive decoding algorithms. in 1st International IEEE EMBS Conf. on Neural Engin. 2003. Capri, Italy. p. 100-103 59. Vetter, R.J., T.A. Becker, J.C. Williams, and D.R. Kipke. The use of ALGEL as an artificial dura for chronic cortical implant neuroprosthetics. in 1st International IEEE EMBS Conf. on Neural Engin. 2003. Capri, Italy: p. 633-636 60. Vetter, R.J., K.J. Otto, T.C. Marzullo, and D.R. Kipke. Brain-machine interfaces in rat motor cortex: Neuronal operant conditioning to perform a sensory detection task. in 1st International IEEE EMBS Conf. on Neural Engin. 2003. Capri, Italy: IEEE. p. 637-640 61. Otto, K.J. and D.R. Kipke, The perceptual effects of multi-electrode spatiotemporal microstimulation in rat auditory cortex. 2002, Society for Neuroscience: Orlando, FL. p. 354.13. 62. Vetter, R.J., J.C. Williams, J.F. Hetke, and D.R. Kipke. Long-term recording properties of implantable thin-film silicon microelectrode arrays in auditory cortex. in Soc. Neurosci. Abstr. 2002. Orlando, . 63. Otto, K. J., P. J. Rousche, and D.R. Kipke (2001). Intracortical microstimulation (ICMS) in rat auditory cortex: examination of relationship between perceptual generalization and stimulus location. Society for Neuroscience, San Diego, CA. 64. Rousche, P. J., K. J. Otto, and D.R. Kipke (2001). Intracortical microstimulation (ICMS) in rat auditory cortex: examination of relationship between pure tone and ICMS-evoked generalization gradient curves. Society for Neuroscience, San Diego, CA. 65. Williams, J.C., M. Holecko, S. Massia, D. Pellinen, P. Rousche, R. Vetter, and D. Kipke (2000), “Hybrid neural implants with integrated bioactive capability”, Presented at Biomedical Engineering Society Meeting, Seattle, WA. October.

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66. Becker, T.A., D. Kipke, and T.A. Brandon (2000), “Microcatheter delivery of a new endovascular occlusion material into an advanced in vivo model of an arteriovenous malformation”, Presented at Biomedical Engineering Society Meeting, Seattle, WA. October. 67. Rousche P., D. Pellinen, J.C. Williams, and D. Kipke (2000), “A ‘flexible’ polymer-substrate intracortical recording array”, presented at the World Congress of Bioengineering, Chicago, Illinois. July. 68. Yoshida, K., D. Pellinen, D. Pivin, P. Rousche, and D. Kipke (2000), “Development of the thin-film longitudinal intra-fascicular electrode”, presented at the International Functional Electrical Stimulation Conference, Aalborg, Denmark. July. 69. Williams, J.C. and D.R. Kipke (1999), "Methods for modeling the relationship between extracellular recording variability and impedance properties of chronic neural implants", Proceedings of the IEEE- EMBS Conference, p 486. 70. Becker, T.A. and D.R. Kipke (1999), "Endovascular embolization of arteriovenous malformations by bi-directional injection of a biocompatible two-component polymer”, Proceedings of the IEEE-EMBS Conference, p 762. 71. Isaacs, R.E., Weber, D.J., Kipke, D.R., and Schwartz, A.B. (1999), “Cortical motor prosthesis control from simultaneously recorded neurons”, Proceedings of the IEEE-EMBS Conference, p 472. 72. Rousche, P.J., D.R. Kipke, and R.S. Witte (1999), “Opponent-pair feature extractors in guinea pig primary auditory cortex”, Neuroscience. Abstr. 25:1665. 73. Witte, R.S. and D.R. Kipke (1999) "Assessing network properties of neural ensembles recorded from chronic, multichannel microwires in auditory cortex of awake, behaving cats", Neuroscience. Abstr. 25:1666. 74. Witte, R.S. and D.R. Kipke (1999), “Evidence of competing neural assemblies in background activity of neurons in auditory cortex of awake guinea pig”, Presented at the Annual Meeting for Computation and Neural Systems, Pittsburgh PA, July. 75. Otto, K.J. and D.R. Kipke (1999), “Investigating neural coding and plasticity in auditory cortex using real-time feedback from ensemble neural recordings”, Presented at the Annual Meeting for Computation and Neural Systems, Pittsburgh PA, July. 76. Otto, K.J. and D.R. Kipke (1999), “Aversive fear conditioning utilizing feedback control based on neural signals from auditory cortex: A novel method to study neural plasticity”, Assoc. Res. in Otolaryngol. Abstr. 22:36 77. Witte, R.S., P.J. Rousche, and D.R. Kipke (1999), “Frequency selectivity and temporal response properties of neural ensembles in the auditory cortex of the awake guinea pig display different degrees of short-term variability”, Assoc. Res. in Otolaryngol. Abstr. 78. Kipke, D.R. (1999), “Investigation of neural prostheses and plasticity using implantable chronic microelectrodes”, Neuroengineering and Mathematical Neuroscience Workshop, Arizona State University, Tempe, Arizona. January 15 and 16. 79. Kipke, D.R., P.J. Rousche, R. Witte, and R.S. Clement (1998), “Temporary psychoacoustical ‘lesions’ induce RF changes in the auditory cortex of the awake guinea pig”, Neuroscience Abstr. 24: 906. 80. Witte, R.S., R.L. Rennaker, R. Clement, P.J. Rousche, J.C. Williams, and D.R. Kipke (1998), “Daily variation of frequency response areas to passive stimulation in auditory cortex of awake cat and guinea pig using chronic multichannel recording microwires”, Neuroscience Abstr. 24: 906. 81. Williams, J.C., R.L. Rennaker, D. Pellinen, and D.R. Kipke (1998), “Time-varying changes in complex tissue impedance immediately following local insult with arrays of chronic microelectrodes in auditory cortex”, Neuroscience Abstr. 24: 906.

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82. Clement, R., R.S. Witte, P.J. Rousche, and D.R. Kipke (1998), “Variation in functional connectivity with passive stimulation in auditory cortex using chronic, multichannel microelectrodes in awake cat and guinea pig”, Neuroscience Abstr. 24: 906. 83. Taylor, D.M., A.B. Schwartz, and D.R. Kipke, (1998), “Improved synchrony detection in multi-unit recording using a modified gravitational technique and pair-wise testing”, Neuroscience Abstr. 24: 657. 84. Kipke, D.R., P.J. Rousche, J.C. Williams, R.S. Clement, R.S. Witte, K. Otto, R.L. Rennaker, and D. Pellinen, “Individual unit responses to simple stimuli can change within large neural ensembles in auditory cortex. Evidence for dynamic neural assemblies?”, Beyond Neurons and Synchrony, Dynamical Neuroscience Satellite Symposium, , CA, Nov 6-7, 1998. 85. Kipke, D.R. and A.B. Schwartz (1998). “Cortical control of neural prostheses: An update”, 29th Neural Prosthesis Workshop, National Instititue of Neurological Disorders and Stroke, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda MD, October 28- 30. 86. Kipke, D.R. and E.J. Guilbeau (1998). “Introduction to Bioengineering at the Freshman Level”, invited presentation at ASEE-BED Conference, Seattle WA, June 28-July 1, 1998. 87. Kipke, D.R. (1998), “Investigations of neural prostheses and neural plasticity using implantable microelectrode arrays”, The 1st Korea-United States Joint Seminar on Biomedical Engineering, Choongnam University, Yoosung, South Korea, May 21-22. 88. J.C. Williams, R.C. Witte, D.R. Kipke (1998). “Long-term unit stability in chronic, multichannel recordings in auditory cortex”, Assoc. Res. in Otolaryngol. Abstr. 89. R.C. Witte, J.C. Williams, D.R. Kipke (1998), “Investigation of dynamic reorganization in auditory cortex using chronic, multichannel neural recordings”, Assoc. Res. in Otolaryngol. Abstr. 90. Kipke, D.R. and A.B. Schwartz (1997). “Cortical control of neural prostheses: An update”, 28th Neural Prosthesis Workshop, National Instititue of Neurological Disorders and Stroke, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda MD, October 15- 17. 91. Kipke, D.R. (1997). “Long-term Unit Stability in Chronic, Multichannel Cortical Recordings”, invited talk as part of the Satellite Symposium, “New Developments in Multichannel Recording and Stimulation”, at the Society for Neuroscience Annual Meeting, New Orleans, LA. October 25. 92. Chi, A., J.C. Williams, P.D. Perepelkin, and D.R. Kipke (1997), “Impedance variations of microelectrode arrays chronically implanted in cerebral cortex”, Biomedical Engineering Society Fall Meeting, San Diego, CA, October 3-5. 93. Becker, T.A., D.R. Kipke, and M.L. Lawton (1997), “Treatment of arteriovenous malformations with endovascular copolymers”, Biomedical Engineering Society Fall Meeting, San Diego, CA, October 3-5. 94. Kipke, D.R. (1997). “Chronic Neural Implants”, invited talk as part of the Biotechnology Symposium, Arizona State University, Tempe, AZ. September 30. 95. Levy, K.L., and D.R. Kipke (1997). “Differences in signal encoding between single-cell and ensemble models of the cochlear nucleus octopus cell”, Sixth Annual Computational Neuroscience Meeting, Bozeman, Montana. July. 96. Lawton, M.L., K.P. Mouneimne, D.R. Kipke, R.F. Spetzler (1997). “Hypothermia-induced circulatory arrest in neurovascular surgery (Part II): Bidirectional copolymer embolization of high-grade arteriovenous malformations. Rocky Mountain Neurosurgical Society 32nd Annual Meeting, Jasper Park, Canada, June 26-30. 97. Kipke, D.R. (1996). “Computer applications in bioengineering: An active-learning laboratory course for undergraduates”, ASEE Conference Proceedings.

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98. Kipke, D.R. (1996). “A model of the encoding of speech in the ventral cochlear nucleus comparing normal cochlear function to cochlear implants”, Society of Neuroscience Abstr. 22 Pt. 3, p. 1822. 99. Kipke, D.R., P.D. Perepelkin, and A.B. Schwartz (1996). “Chronic multiunit recording in monkey motor cortex: Implications for control of a motor prosthesis”, Annals of Biomedical Enginnering (Suppl), 24: 68. 100. Kipke, D.R. and K.L. Levy (1996). “Encoding the fundamental frequency of speech in noise in the ventral cochlear nucleus: A modeling study”, Assoc. Res. in Otolaryngol. Abstr. 19:171. 101. Kipke, D.R. and Dettloff, R.O. (1996) “Examining the stability of recordings from multichannel electrode arrays in auditory cortex”. Assoc. Res. in Otolaryngol. Abstr. 19:115. 102. Levy, K.L. and D.R. Kipke (1995). “Indications that octopus cells of the cochlear nucleus precisely respond to the envelope of tones and speech in background noise: A modeling study”. Assoc. Res. in Otolaryngol. Abstr. 18:128. 103. Rasmussen, M. and D.R. Kipke (1996). “A model of the electrically stimulated cochlea: Application to cochlear implants”, Arizona Neuroscience Annual Meeting, Tucson, AZ. January. 104. Levy, K.L. and D.R. Kipke (1995). “Modeling the effects of cochlear electrical stimulation on responses of the cochlear nucleus octopus cell”. Conference on Implantable Auditory Prostheses. August, 1995, Asilomar, CA. 105. Levy, K.L. and D.R. Kipke (1994). “The effects of dendritic and synaptic simplifications in a compartmental model of a cochlear nucleus octopus cell”, Annals of Biomedical Enginnering (Suppl) 22(1):52. 106. Kipke, D.R. (1994). “Shared-stimulus driving and connectivity in groups of neurons in the dorsal cochlear nucleus” Annals of Biomedical Enginnering (Suppl) 22(1):55. 107. Westbrook, J.T. and D.R. Kipke (1994). “Increasing dynamic range in a cochlear model using high, medium, and low spontaneous rate fibers”, Computations and Neural Systems Meeting, Monterey, California. July. 108. Herzog, E., D.R. Kipke, M. Powers, and R.B. Barlow, Jr. (1992). “Computational analysis of the Limulus retina: Simulation of visually-guided behavior”, Soc. Neuroscience Abstr. 18 Pt. 1: 136. 109. Kipke, D.R., B.M. Clopton and D.J. Anderson (1990). “Stimulus coding of complex sounds by small groups of neurons in the cochlear nucleus”, Soc. Neuroscience Abstr. 16 Pt. 1: 718. 110. Clopton, B.M., P.M. Backoff and D.R. Kipke (1990). “System estimation and response prediction from high-resolution spectrotemporal receptive fields in cochlear nucleus”, Assoc. Res. in Otolaryngol. Abstr. 13:337. 111. Kipke, D.R., D.J. Anderson and B.M. Clopton (1988). “Multiple unit discrimination in the cochlear nucleus using a four-channel solid-state sensor and microcomputer-based system”, Assoc. Res. in Otolaryngol. Mid-Winter meeting. 112. Anderson, D.J., Clopton, B.M. and Kipke, D.R. (1987). “Signal processing of thin film neural recording array data to separate channels of point process information”, IEEE Engin. in Medicine and Biol. Society Annual Meeting.

INVITED SEMINARS AND LECTURES 1. Keynote speaker, 3rd International IEEE EMBS Conference on Neural Engineering, Honolulu, Hawaii (May, 2007) 2. NIH Neural Interface Workshop, Bethesda, MD, “National Center for Neural Communication Technology: Developing advanced microscale devices for chronic neural interfaces”, (August, 2006)

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3. World Congress on Medical Physics and Biomedical Engineering 2006, Seoul, South Korea, “Advanced implantable microscale neural interface devices” (August, 2006) 4. International Workshop on Neural Interface Technologies and Applications, Kunming, China, “Advanced implantable microscale neural interface devices” (July, 2006) 5. Gordon Research Conference on MEMS Technology & Biomedical Applications, “Implantable microsystems for monitoring and stimulating the brain”, Connecticut College (June, 2006) 6. Symposium on Electro-Biological Interfaces on Soft Substrates, Material Research Society Spring Meeting, San Francisco, “Microscale neural implant systems for neuroprostheses” (April, 2006) 7. Biomedical Engineering Lecture Series, , “Microscale neural implant systems for neuroprostheses”, (March, 2006) 8. Biomedical Engineering Lecture Series, , “Implantable neural probe systems for interfacing with the brain” (March, 2006) 9. WTEC Study on Brain Computer Interfaces, North American Baseline Workshop, “Implantable Microscale Neural Interface Devices for BCI systems”, Arlington, VA (February, 2006) 10. University of Southern California Biomimetic MicroElectronic Systems Engineering Research Center, Research Symposium focusing on Cell Biology, “Implantable microscale neural interface devices”, Los Angeles, CA (January, 2006) 11. University of Michigan Medical School, Department of Anesthesiology research seminar, “Implantable microscale neural interface devices”, Ann Arbor, MI (January, 2006) 12. McGowan Institute for Regenerative Medicine Seminar Series, , “Microscale neural implant systems for neuroprostheses”, (October, 2005) 13. Neural signal and information procession session, Biomedical Engineering Society Fall Meeting, Baltimore, “Co-adaptive cortical control using multi-modal neural signals” (September, 2005). 14. German Society for Biomedical Engineering and the International Conference on Medical Physics, Nuremburg Germany, “Microscale neural implant systems for neuroprostheses”, (September, 2005) 15. Symposium on Frontiers of Neural Engineering, , Beijing, China, “Talking to the brain: Implantable microelectrode arrays for microscale neural interfaces”, (August, 2005) 16. Workshop on Brain-Computer Interfaces, Rensselaer, New York, “Research in the University of Michigan Neural Engineering Laboratory”, (June, 2005) 17. Internal Medicine Grand Rounds, University of Michigan, “Talking to the brain: Implantable microelectrode arrays for microscale neural interfaces”, (June, 2005) 18. Regenerative Medicine Showcase, University of Michigan, “Implantable neural probe systems for interfacing with the brain”, (May, 2005) 19. NASA Bioscience and Engineering Institute Research Symposium, University of Michigan, “Implantable neural probe systems for interfacing with the brain”, (May, 2005) 20. Biomedical Engineering Lecture Series, Pennsylvania State University, “Microscale neural implant systems for neuroprostheses”, (March 25, 2005) 21. Whitaker Foundation Biomedical Engineering Summit, Landsdowne, Virginia, Organizer for Neural Engineering Workshop (with Ravi Bellamkonda), (March 4-6, 2005) 22. Invited seminar, “Microscale neural implant systems”, NIH Neural Interface Workshop, Bethesda, MD, (Nov 16, 2004). Presented by Rio Vetter because of a family obligation. 23. Invited presentation, “Direct brain interfaces & neuroprosthetics”, Joint reception of the University of Michigan College of Engineering and the Medical School, Ann Arbor, MI (Nov 11, 2004). 24. Invited seminar, “Implantable neural probe systems for interfacing with the brain”, International Forum on Biochip Technology 2004, China Ministry of Science and Technology, Beijing, China (Oct 21, 2004) (invitation declined due to scheduling conflict)

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25. Invited presentation, “Implantable probe systems for cortical neuroprotheses,” (Invited), Proceedings of the 26th International IEEE-EMBS Conference (San Francisco, CA), pp. 5344-5347, (September 2004). 26. Invited lecture, “Implantable neural probe systems for cortical neuroprostheses”, Neural Engineering Research Day, Case Western Reserve University, Cleveland, Ohio (Aug. 27, 2004) 27. Invited presentation, “Implantable probe systems for cortical neuroprostheses,” (Invited), Proceedings of the International Joint Conference on Neural Networks (Budapest, Hungary), (July 2004). 28. Invited seminar, “Implantable neural probe systems for cortical neuroprostheses”, , New Haven, Connecticut, (May 5, 2004) 29. Invited presentation, Investigator Workshop for DARPA Bio, Info, Micro Program, San Francisco, CA (November, 2003). 30. Invited presentation, Neural Prosthesis Workshop, Bethesda, MD (October, 2003). 31. Invited presentation, Biomedical Engineering Society, Nashville, TN (October, 2003). 32. Invited presentation, BioMEMS and Nanotech World 2003: The Convergence of Technology to Transform Medicine, sponsored by the Cambridge Healthtech Institute and the International Society for BioMEMS and Biomedical Nanotechnology. Washington, D.C. (August, 2003) 33. Invited presentation, DARPA Brain-Machine Interface Program, Investigator Meeting, Arlington, VA (July, 2003) 34. Invited presentation, 3rd International Conference on bioMEMS 2003, sponsored by The Knowledge Foundation. San Jose, CA (June, 2003) 35. Invited presentation, Annual Meeting of the University of Michigan College of Engineering National Advisory Committee (April, 2003) 36. Invited presentation, Kickoff meeting for DARPA Brain-Machine Interface Program, Arlington, VA (October, 2002) 37. Invited keynote lecture, Investigator Workshop for DARPA Bio, Info, Micro Program, Boston, MA (October, 2002) 38. Invited presentation, Brain-computer Interface Workshop, Rennesalaer New York, (July, 2002) 39. Invited presentation, Neuromodulation 2002: Defining the Future, Aix-Les-Bains, France (June, 2002) 40. Invited seminar, Hearing and Chemical Senses Seminar, Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan (April 2002) 41. Invited lecture, Neurosurgery Grand Rounds, The Cleveland Clinics Foundation, Cleveland, Ohio (November, 2001) 42. Invited seminar, Sloan Seminar Series, California Institute of Technology, Pasadena, California (June, 2001) 43. Workshop on Bionics jointly sponsored by European Union and National Science Foundation, Brussels, Belgium (June, 2001) 44. Invited presentation, “Recent advances in neuroprostheses to control and monitor brain function”, SCANDLAS 20001 Conference, Aarhus, Denmark. (May, 2001) 45. Invited lecture, Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan (March 2001) 46. Invited Lecture, Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania (February 2001) 47. Advances in Neuroprosthetics Lecture Series, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio (February 2001) 48. Invited presentation, Winter Brain Conference, “Advances in Neuroprosthetics” session, Steamboat Springs, Colorado (January 2001). 49. Mathematics and Cognition Seminar, Arizona State University, Tempe, Arizona (December 2000)

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50. Bio-futures Kickoff Workshop, DARPA, Virginia (October 2000). 51. Neural Prosthesis Workshop, NINDS & NIDCD, Bethesda, Maryland (October 2000). 52. Satellite Symposium on, “New Developments in Multichannel Recording and Stimulation”, at the Society for Neuroscience Annual Meeting, Miami Beach, Florida, (October 1999). 53. Neural Prosthesis Workshop, NINDS & NIDCD, Bethesda, Maryland (October 1999). 54. Neural Prosthesis Workshop, NINDS & NIDCD, Bethesda, Maryland (October 1998). 55. Joint US-Korea Workshop on Biomedical Engineering Approaches to Physiological Function Analysis, Seoul, South Korea (May 1998). 56. Neural Prosthesis Workshop, NINDS & NIDCD, Bethesda, Maryland (October 1997). 57. Satellite Symposium on, “New Developments in Multichannel Recording and Stimulation”, at the Society for Neuroscience Annual Meeting, New Orleans, Louisiana (October 1997). 58. Mathematics and Cognition Seminar, Arizona State University, Tempe, Arizona (October 1996) 59. Session on Outstanding Bioengineering Courses, ASEE Annual Meeting, Washington D.C. (June, 1996) 60. Neural Engineering Workshop, Arizona State University, Tempe, Arizona (February 1996). 61. Biomedical Instrumentation Workshop, , Tucson (April 1994). 62. of Biological Systems Workshop, University of Arizona, Tucson (April 1994).

PATENTS and INVENTIONS 1. D.R. Kipke, T. A. Becker, and V. E. Collins, “Method for forming an endovascular occlusion”, US patent 6,592,566. July 15, 2003. 2. D.R. Kipke, J.C. Williams, P.J. Rousche, D.S. Pellinen, and D. Pivin, “Device for creating a neural interface and method for making same,” U.S. patent 6,829,498, December 7, 2004. 3. T.A. Becker, D.R. Kipke, and C.G. McDougall, “Composition and methods for improved occlusion of vascular defects”. U.S. patent application 10/738,317, December 2003. 4. D. R. Kipke, T. A. Becker, J.C. Williams, and R.J. Vetter, “Compositions and methods for use of alginate dural sealants”, U.S. patent application 60/453,305, March, 2004. 5. D.R. Kipke, J.C. Williams, P.C. Garell, J. Henderson, and J. Hetke, “Intracranial neural interface system”, U.S. patent application 10/970,268, October 21, 2004. 6. D.R. Kipke and D.S. Pellinen, “Polymer-based neural probes for extended recording lifetime”, U.S. patent application, June, 2006. 7. J. Hetke, D.R. Kipke, D.S. Pellinen, and D.J. Anderson, ”Modular multichannel microelectrode array and method of making same”, U.S. patent application, PCT/IB2006/053700, October 10, 2006. 8. J. Seymour and D.R. Kipke, “Microelectrode with laterally extending platform for reduction of tissue encapsulation”, U.S. PCT application, January, 2007.

TECHNOLOGY TRANSFER I have co-founded two startup companies in the neurotechnology industry. Neural Intervention Technologies, Inc., Ann Arbor, Michigan (founded in 2002; acquired in 2006) Co-founder & Chief Scientific Officer Neural Intervention Technologies developed and commercialized an alginate-based liquid embolic agent for minimally invasive treatment of neurovascular defects. This work was started in my laboratory at Arizona State University in 1998. The core technologies were licensed from the University of Michigan and Arizona

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State University. Neural Intervention Technologies was acquired by W.L. Gore, Inc. in July 2006 in a $14M cash deal. Gore is a diversified polymer materials company with a major biomedical materials division.

NeuroNexus Technologies, Inc., Ann Arbor, Michigan (founded in 2004) Co-founder & President/CEO NeuroNexus Technologies is developing microscale neural interface devices for the medical and neuroscience research markets. NeuroNexus has successfully commercialized a family of innovative neural interface products for animal neuroscience research that are being sold around the world. NeuroNexus is developing its first clinical products that are targeted at the neurosurgery device market. The company currently has 5 full-time professional employees and is positioned for rapid growth in the next two years. Its core technologies are licensed from the University of Michigan, several of which were developed in Dr. Kipke’s Neural Engineering Laboratory.

TEACHING Undergraduate Courses 1. ECE 106 – Introduction to C programming (Arizona State University) 2. BME 201 – Developed -- Introduction to Bioengineering (Arizona State University) 3. BEN 220 – Developed -- Digital design for bioengineers (Syracuse University) 4. BME 413/423 – Medical Instrumentation – lecture and laboratory (Arizona State University) 5. BME 470 – Developed -- Computer Applications in Bioengineering – lecture and laboratory (Arizona State University) 6. BiomedE 458 – Re-designed -- Biomedical Instrumentation – lecture and laboratory (University of Michigan)

Graduate Courses 1. BME 513/523 – Medical Instrumentation – lecture and laboratory (Arizona State University) 2. EE 520 – Digital Signal Processing (Syracuse University) 3. BME 524 – Applied Neural Control (Arizona State University) 4. BME 598 – Developed -- Computational Neuroscience (Arizona State University) 5. BME 598 –– Developed -- Auditory Physiology and Plasticity (Arizona State University) 6. BME 598 –– Developed -- Fundamentals of Neural Coding (Arizona State University) 7. BME 598 –– Developed -- Design of Neural Prosthetics (Arizona State University) 8. BME 598 -– Developed -- Advanced Physiology (co-taught, Arizona State University) 9. BiomedE 599 – Developed -- Neural Implants and Neuroprosthetic Systems (University of Michigan). This course will be renamed “ 10. Neuroscience 602 – Taught the module on ‘Motor Control’ (Winter, 2005) 11. BiomedE 599 – Developed – Neural Engineering (Fall, 2006)

POST-DOCTORAL RESEARCHERS 1. Justin Williams, Ph.D. (Bioengineering), Arizona State University. (Assistant Professor, Department of Biomedical Engineering, University of Wisconsin at Madison). 2. Ruben Rathnasingham, Ph.D. (Aeronautical Engineering), Massachusetts Institute of Technology. 3. Timothy Becker, Ph.D. (Bioengineering), Arizona State University. (Product Development Specialist, W.L. Gore, Inc., Flagstaff, Arizona)

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4. Patrick Rousche, Ph.D. (Bioengineering), University of Utah. (Assistant Professor, Department of Biomedical Engineering, University of Illinois at Chicago) 5. Philip Sabes, Ph.D. (Cognitive Science), Massachusetts Institute of Technology. (Assistant Professor, Department of Physiology, at San Francisco). 6. Rio Vetter, Ph.D. (Biomedical Engineering), University of Michigan. (Product Development Specialist, NeuroNexus Technologies, Inc.) 7. Mark Lehmkuhle, Ph.D. (Bioengineering), University of Utah. 8. Sandeep Bhangoo, M.D., Neurosurgery Resident at Henry Ford Hospitals, , Michigan.

STUDENTS Doctoral Students -- Graduated 1. Kenneth Levy. “The transformations of acoustic information by cochlear nucleus octopus cells: A modeling study,” (1996). Presently working at Director of New Technology software engineer). 2. Timothy Becker. “Endovascular embolization of arteriovenous malformations”. (2001). Presently Chief Technology Officer, Neural Intervention Technologies, Inc., Ann Arbor, Michigan. 3. Justin Williams. “Performance of chronic neural implants: Measurement, modeling, and intervention strategies” (2001). Now a tenure-track Assistant Professor at the University of Wisconsin at Madison. 4. Russell Witte. “Dynamic plasticity in auditory cortex”, (2002). Now a Senior Research Fellow in the Biomedical Ultrasound Laboratory at the University of Michigan. 5. Ryan Clement. ”The electrical stapedius reflex”, (2002). Now a tenure-track Assistant Professor in Biomedical Engineering at Penn State University. 6. Robert Rennaker. “Neural synchrony, auditory cortex plasticity, and behavior” (2002). Now a tenure- track Assistant Professor in Biomedical Engineering at the . 7. Kevin Otto, “Intracortical microstimulation for sensory inputs in brain-machine interfaces” (2003; Arizona State University). Current position: Assistant Professor, Biological Sciences and Biomedical Engineering, . 8. Rio Vetter, Biomedical Engineering, (May, 2004). Current position: Product Specialist at NeuroNexus Technologies, Inc., Ann Arbor, Michigan. 9. David Pellinen, “Multifunctional flexible polymer-based intracortical neural recording microelectrodes”, Biomedical Engineering (April, 2005). Current position: Microfabrication engineer at NeuroNexus Technologies, Inc., Ann Arbor, MI 10. Elizabeth Nunamaker, “Alginate as a novel material for duraplasty: Investigation of the material properties, in vivo stability, and sealing capabilities”, Biomedical Engineering (May, 2006) Current position: Veterinarian student at Purdue University 11. Matthew Johnson, “Spatio-temporal neural interface dynamics elucidated with multichannel electrochemistry”, Biomedical Engineering (January, 2007) Current position: Research scientist at Cleveland Clinic Foundation 12. Jeyakumar Subbaroyan, “Investigations of tethering induced injury response in brain tissue by intracortical implants through modeling and in vivo experiments”, Biomedical Engineering (January, 2007) Current position: Research scientist at the University of Michigan

Doctoral Students – Current 1. Jeyakumar Subbaroyan, Biomedical Engineering - (2001- 11/06) 2. Nicholas Langhals, Biomedical Engineering – (2001 - 5/06) 3. Greg Gage, Biomedical Engineering – (2002 – 5/07) 4. Kip Ludwig, Biomedical Engineering – (2002 – 6/07)

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5. John Seymour, Biomedical Engineering – (2002 – 9/07) 6. Timothy Marzullo, Neuroscience – (2002 – 6/07) 7. Hirak Pirak, Biomedical Engineering -- (2003 – 12/07) 8. Erin Purcell, Biomedical Engineering – (2003 – 5/08) 9. Jongwoo Lee, Electrical Engineering – (2003 – 6/07) 10. Luis Salas, Biomedical Engineering – (2004 – 5/09) 11. Matthew Gibson, Biomedical Engineering – (2005 – 2009) 12. Takahashi Yoshida, Biomedical Engineering – (2005 – 2009) 13. Azadeh Yazdan, Biomedical Engineering -- (2006-2009) 14. David Turer - (2006-2011)

Doctoral Research – Committee Member Selected from approximately 25 students 1. Brian Jamieson, Biomedical Engineering – (Ken Wise, Chairman; defended in December, 2002) 2. Robert Franklin (Electrical Engineering; Richard Brown, Chairman) 3. Mohammad Abidian (Biomedical Engineering; David Martin, Chairman)

Graduate Research – Master’s level Selected from approximately 20 students 1. Shani Ross, Biomedical Engineering (Biomedical Engineering, Graduated in 2006) 2. Rachel Miriani (Biomedical Engineering, Graduated in 2004) 3. K.C. Kong (Biomedical Engineering, Graduated in 2003).

Undergraduate Research Selected from approximately 25 students 1. Eugene Danishvar, Electrical Engineering, 2004-2006 2. Nicholas Douville, Biomedical Engineering, 2003-2004 – accepted to MSTP program at Michigan 3. Katherine Scott, Computer Engineering, 2003-2004 4. Kaylan Brakora, Materials Science and Engineering, 2002-2004

SERVICE 2006, Member, Chair Search Committee, Department of Biomedical Engineering 2006, Member, Faculty Search Committee, Department of Biomedical Engineering 2006, Session chair, Neural Engineering, Biomedical Engineering Society Conference, Chicago, Illinois (October, 2006) 2006, Chairman, NIH Special Panel on Neurotechnologies 2004-2006, Reviewer, NIH Study Section Brain Disorders and Clinical Neuroscience 2003-2006, Associate Editor, IEEE Transactions on Biomedical Engineering 2005-present, University of Michigan, Office of Vice President, Conflict of Interest Committee 2005, Track chair, Neural Engineering, IEEE Conference on Engineering in Medicine and Biology, Shainghai, China (September, 2005) 2005, Chair, Department of Biomedical Engineering Internal Review Committee

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2004, Reviewer, Journal of Neural Engineering 2004, Member, Biomedical Engineering Search Committee for Junior Faculty member 2004, Invited presentation, Detroit Area Pre-College Engineering Program, University of Michigan, March. 2004, Co-organizer, Neural Engineering, IEEE Conference on Engineering in Medicine and Biology, San Francisco, CA, October. 2002-2004, Qualifying Exam Coordinator, Department of Biomedical Engineering 2002-2004, Bioelectrical Concentration Advisor, Department of Biomedical Engineering 2001-2004, Graduate Education Committee, Department of Biomedical Engineering 2003-2004, Member, Department of Biomedical Engineering Awards Committee 2003-2004, Member, College of Engineering, Special Committee on (Brian Gilchrist, chair). 2003, Organizer, Satellite Symposium on Advances in Neural Probe Applications and Technologies, a satellite symposium to the Society for Neuroscience Conference, New Orleans, November. 2003, Reviewer, NIH Biomedical Engineering, Ad hoc review panel 2003, Reviewer, VA Biomedical Research Merit Review Program 2003, Marshal in University Graduation Ceremonies, University of Michigan 2003-2004, Reviewer, Journal of Neuroscience Methods 2003-2004, Reviewer, IEEE Transactions on Biomedical Engineering 2003, Track chair (microinstrumentation), IEEE EMBS Annual Meeting, Cancun, Mexico 2003 Ad hoc reviewer, FWF Der Wissenschaftsfonds (Austrian Science Fund) 2003 Ad hoc reviewer, National Institute of General Medical Sciences, Minority Biomedical Research Support Program 2002-2003, Ad hoc reviewer, National Institute for Deafness and Communication Disorders, Small Grant Program 2002-2003, Biomedical Engineering Undergraduate Curriculum Committee, member, Department of Biomedical Engineering 2002-2003, Head graduate advisor, Department of Biomedical Engineering 2002, Rackham Predoctoral Faculty Selection Committee, University of Michigan 2001, Session Co-chair (neural engineering), Biomedical Engineering Society Annual Meeting, Raleigh NC (proposed but not yet finalized by program committee). 2000-2001, Department Audit Committee (ad hoc, appointed by Dean) 2000-2001, College of Engineering Curriculum Committee: Statistics 2000-2001, Dean’s Research Advisory Committee 2000-2001, Arizona State University Institutional Animal Use and Care Committee (IACUC) 2000-2001, Arizona State University Animal Users Advisory Committee 2000-2001, Co-chairman, Bioengineering Faculty Search Committee, BioMEMS position. 2000-2001, Personnel Committee, Department of Biomedical Engineering. 1998-2001, Ad hoc review panel member, NIH-NIDCD small grants program. 2000, Ad hoc review panel member, NIH-NINDS program for deep brain implants. 1999, Review panel member, NSF Bioengineering and Environmental Systems Program. 1999, Session Co-chair (neural engineering), Biomedical Engineering Society Annual Meeting, Atlanta GA. 1999-2000, Bioengineering Faculty Search Committee, Neural Engineering positions (hired Jit Muthuswamy and Leon Iasemedis) 1998-1999, Bioengineering Faculty Search Committee, Bioengineering Program January, 2007 Page 18 of 19 Daryl R. Kipke Vitae

1996, External reviewer, Speech and Hearing Science Doctoral Program Admissions Committee 1994, Neural Engineering Track Organizer, Biomedical Engineering Society Annual Meeting, Tempe AZ 1993-95, Biomedical Lecture Series, Co-organizer with G. Stelmach 1994-1995, Bioengineering Search Committee (hired J. He) 1992-1993, Graduate Committee for Bioengineering

COLLABORATORS (selected) • William Shain, Ph.D., Wadsworth Center, New York State Department of Public Health • Robert Kennedy, Ph.D., Department of Chemistry, University of Michigan • Kensall Wise, Ph.D., Department of Electrical Engineering and Computer Science, University of Michigan • David Martin, Ph.D., Department of Materials Science and Engineering, University of Michigan • Steven Goldstein, Ph.D., Department of Orthopedics, University of Michigan Medical School • Paul Cederna, M.D., Department of Surgery, University of Michigan Medical School • Parag Patil, M.D., Ph.D., Department of Neurosurgery, University of Michigan Medical School • Richard Brown, Ph.D., Department of Electrical Engineering and Computer Science, University of Utah • Edward Ionides, Ph.D., Department of Statistics, University of Michigan • Victor Solo, Ph.D., Department of Electrical Engineering and Computer Science, University of Michigan

PROFESSIONAL AFFILIATIONS • IEEE • Biomedical Engineering Society • Society for Neuroscience • American Association for the Advancement of Science • American Clinical Neurophysiology Society

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