DARYL R. KIPKE Department of Biomedical Engineering Email: [email protected] 2212 Lurie Biomedical Engineering Building Office: (734) 764-3716 1101 Beal Avenue Fax: (734) 786-0072 University of Michigan URL: nelab.engin.umich.edu Ann Arbor, MI 48109-2099 EDUCATION 1991 Ph.D., Bioengineering University of Michigan, Ann Arbor, MI 1988 M.S.E., Electrical Engineering University of Michigan, Ann Arbor, MI 1986 M.Sc., Bioengineering University of Michigan, Ann Arbor, MI 1985 B.Sc., Engineering Science University of Michigan, Ann Arbor, MI PROFESSIONAL EXPERIENCE 2001-present Associate Professor (tenured) University of Michigan, Ann Arbor, MI 1998-2001 Associate Professor (tenured) Arizona State University, Tempe, AZ 1992-1998 Assistant Professor Arizona State University, Tempe, AZ 1991-1992 Post-doctoral Research Fellow Syracuse University, Syracuse, NY 1991-1992 Adjunct Instructor Syracuse University, Syracuse, NY 1986-1991 Graduate Research Assistant University of Michigan, Ann Arbor, MI Primary appointment in Department of Biomedical Engineering Member of Hearing, Balance, and Chemical Senses Program faculty Member of Neuroscience Program faculty 2001-pres. Principal Investigator, Neural Engineering Laboratory, University of Michigan 2003-pres. Director, National Center for Neural Communication Technology, University of Michigan 2004-pres. Co-Founder and President/CEO, NeuroNexus Technologies, Inc., Ann Arbor, Michigan 2002-2006 Group leader for Biomedical Sensors and Subsystems, NSF Engineering Research Center for Wireless Integrated Microsystems, University of Michigan 2002-2006 Co-Founder and Chief Scientific Officer, Neural Intervention Technologies, Inc., Ann Arbor, Michigan. 2004-2006 Group leader for BioMEMS, NASA Bioscience and Engineering Institute, University of Michigan AWARDS AND HONORS • National Institutes of Health FIRST award (1995) • National Science Foundation CAREER award (1995) • American Heart Association – Arizona Affiliate, Grant-in-Aid (1997) • U.S. delegate to U.S.-South Korea joint Bioengineering Symposium (1998) • Fellow, American Institute of Medical and Biological Engineering (2004) • Department Achievement Award, Department of Biomedical Engineering, University of Michigan (2005) 1 Daryl R. Kipke Vitae • National Academies Keck Futures Initiative Conference Fellowship (2006) RESEARCH AREAS • Implantable microscale neural interface devices for applications in neuroscience and functional neurosurgery • Neuroprostheses and brain-machine interface systems • Auditory neurophysiology and neural plasticity PUBLICATIONS Peer-reviewed journal papers 1. Witte, R. S., P. J. Rousche, and D.R. Kipke, “Fast wave propagation in auditory cortex of an awake cat using a chronic microelectrode array”, Journal of Neural Engineering (In press) 2. Nunamaker, E. A., E. Purcell, and D.R. Kipke, “In vivo stability and biocompatibility of implanted calcium alginate disks”, Journal of Biomedical Materials Research: Part A (In press) 3. Johnson, M.D. O. Kao, and D.R. Kipke, “Spatiotemporal pH dynamics following insertion of neural microelectrode arrays”, Journal of Neuroscience Methods (In press, doi:10.1016/j.jneumeth.2006.09.023). 4. Marzullo, T.C. and C.R. Miller and D.R. Kipke, “Suitability of the cingulated cortex for neural control”, IEEE Transactions on Neural Systems and Rehabilitation, 14(4), pp 401-409, 2006. 5. Otto, K. J., M. D. Johnson, and D. R. Kipke, "Voltage pulses change neural interface properties and improve unit recordings with chronically implanted microelectrodes," IEEE Trans Biomed Eng, 53 (2), pp 333-340, 2006. 6. Ludwig, K. A., J. Uram, J. Yang, D. C. Martin, and D.R. Kipke, "Chronic recording performance of silicon microelectrode arrays with conductive polymer recording sites," J Neural Engin. 3 (1), pp. 59-70, 2006. 7. Subbaroyan, J., D.C. Martin, and D.R. Kipke, "A finite-element model of the mechanical effects of implantable microelectrodes in the cerebral cortex," J Neural Engin., 2:103-113, 2005 8. Williams, J.C., M. Holecko, S. P. Massia, P. J. Rousche, and D. R. Kipke, "Multi-site incorporation of bioactive matrices into MEMs-based neural probes," J Neural Engineering, 2, pp. L23-L28, 2005. 9. Gage, G. J., K. A. Ludwig, K. J. Otto, E. L. Ionides, and D. R. Kipke, "Naive coadaptive cortical control," J Neural Engineering, 2(2), pp 52-63, 2005. 10. Otto, K. J., P. J. Rousche, and Kipke D.R., "Best-frequency dependent behavior induced by cortical microstimulation in auditory cortex of rat," J Neural Engineering, 2(2), pp 42-51, 2005. 11. Johnson, M. D., K. J. Otto, and D. R. Kipke, "Repeated voltage biasing improves unit recordings by reducing resistive tissue impedances," IEEE Trans Neural Syst Rehabil Eng, 13(2), pp.160-165, 2005. 12. Otto, KJ, PJ Rousche, and DR Kipke, “Microstimulation in auditory cortex provides a substrate for detailed behaviors”, Hearing Research, 210(1-2), pp 112-117. 2005. 13. Becker, T. A., M. C. Preul, W. D. Bichard, D. R. Kipke, and C. G. McDougall, "Calcium alginate gel as a biocompatible material for endovascular AVM embolization: six-month results in an animal model," Neurosurgery, vol. 56, pp. 793-801, 2005 14. Witte, R.S. and Kipke, D. R., "Enhanced contrast sensitivity in auditory cortex as cats learn to discriminate sound frequencies," Cognitive Brain Research, vol. 22, pp. 171-184, 2005 January, 2007 Page 2 of 19 Daryl R. Kipke Vitae 15. Vetter, R.J., J. C. Williams, J. F. Hetke, E. A. Nunamaker, and D.R. Kipke, "Spike recording performance of implanted chronic silicon-substrate microelectrode arrays in cerebral cortex," IEEE Trans Biomed Eng, (51) 6:896-904, 2004 16. Wise, K.D., D. J. Anderson, J. F. Hetke, D. R. Kipke, and K. Najafi, "Wireless implantable microsystems: High-density electronic interfaces to the nervous system," Proceedings of the IEEE, (92) 1:76-97, 2004. 17. Rathnasingham, R., S. C. Bledsoe, J. D. McLaren, and D. R. Kipke, "Characterization of implantable microfabricated fluid delivery devices," IEEE Trans. in Bio. Eng. 2004, 51(1): 138-145. 18. Kipke, D.R., R.J. Vetter, J.C. Williams, and J.F. Hetke, Silicon-substrate intracortical microelectrode arrays for long-term recording of neuronal spike activity in cerebral cortex. IEEE Trans Rehab. Engin, 2003. 11(2): 151-155. 19. Rousche, P.J., K.J. Otto, M.P. Reilly, and D.R. Kipke, Single-electrode intracortical micro-stimulation of rat auditory cortex: an evaluation of behavioral performance. Hearing Research, 2003. 179(1-2): p. 62- 71. 20. Becker, T.A., D.R. Kipke, M.C. Preul, W.D. Bichard, and C.G. McDougall, In vivo assessment of calcium alginate gel for endovascular embolization of a cerebral arteriovenous malformation model using the Swine rete mirabile. Neurosurgery, 2002. 51(2): p. 453-8; discussion 458-9. 21. Becker, T.A. and D.R. Kipke, Flow properties of liquid calcium alginate polymer injected through medical microcatheters for endovascular embolization. J Biomed Mater Res, 2002. 61(4): p. 533-40. 22. Clement, R.S, D.R. Kipke, and P. Carter (2002), “Measuring the electrical stapedius reflex with stapedius muscle EMG recordings ”, Annals of Biomedical Engineering, 30(2): 169-179. 23. Rousche, P.J., D. Pellinen, D. Pivin, J.C. Williams, R. Vetter, and D. R. Kipke (2001), “ ‘Flexible’ Polyimide-based intracortical electrode arrays with bioactive capability”. IEEE Trans. on Biomedical Engineering, 48(3):361-371. 24. Becker, T.A., D.R. Kipke, and T. Brandon (2001), “Calcium alginate gel: A biocompatible and mechanically stable polymer for endovascular embolization”, Journal of Biomedical Materials Research, 54, 76-86, 25. Williams, J.C., R.L. Rennaker, and D.R. Kipke (1999), “Long-term neural recording characteristics of wire microelectrode arrays implanted in cerebral cortex”, Brain Research Protocols, 4:303-313. 26. Clement, R.C., R.S. Witte, P.J. Rousche, and D.R. Kipke (1999), “Functional connectivity in auditory cortex using chronic, multichannel unit recordings”, Neurocomputing, 26-27:347-354. 27. Witte, R.S., K.J. Otto, J.C. Williams, and D.R. Kipke (1999), “Pursuing dynamic reorganization in auditory cortex using chronic, multichannel unit recordings in awake, behaving cats”, Neurocomputing, 26-27:593-600. 28. Williams, J.C., R.L. Rennaker, and D.R. Kipke (1999), “Stability of chronic multichannel neural recordings: Implications for a long-term neural interface”, Neurocomputing, 26-27:1069-1076. 29. Levy, K.L. and D.R. Kipke (1998). “Mechanisms underlying the cochlear nucleus octopus cell’s onset response: Synaptic effectiveness and spike threshold”. Journal of the Acoustical Society of America, 103(4):1940-1950. 30. Kipke, D.R. and Levy, K.L (1997). “Sensitivity of the cochlear nucleus octopus cell to synaptic and membrane properties: A modeling study”. Journal of the Acoustical Society of America, 102(1):391- 402. 31. Levy, K.L. and D.R. Kipke (1997). “A model of the cochlear nucleus octopus cell”. Journal of the Acoustical Society of America, 102(1):403-412. January, 2007 Page 3 of 19 Daryl R. Kipke Vitae 32. Kipke, D.R., B.M. Clopton, and D.J. Anderson (1991). “Shared-stimulus driving and connectivity in groups of neurons in the dorsal cochlear nucleus”, Hearing Research 55:24-38. In review 33. Seymour, J. P. and D. R. Kipke, “Biosensor design for reduced encapsulation in the CNS”, Journal of Biomaterials (in revision) 34. Nunamaker, E. A. and D. R. Kipke, “A hydrogel dura mater replacement for use with intracortical electrodes”, Journal of Neural Engineering (in revision) PUBLICATIONS Book chapters or edited volumes 1. Rousche, P. J. and D. R. Kipke, "Next generation of cortical devices," in Neuroprosthetics: Theory and Practice, K. Horch and G. S. Dhillon, Eds. London: Imperial College Press, 2004. 2. Kipke, D.R, D. S. Pellinen, and P. J. Rousche, "CNS recording electrodes and techniques," in Neuroprosthetics: Theory and Practice, K. Horch and G. S. Dhillon, Eds.: World Scientific Pub. Co., 2004. 3. Si, J., D.R. Kipke, S. Lin, A.B. Schwartz, and P.D. Perepelkin (1997). “Motor Cortical Information Processing” in Strategies in the Study of Biological Neural Networks (H. Eichenbaum and J.L. Davis, Editors). Wiley Press, New York. 4.