Trenbolone acetate T 209 1
2-chloro- semicorbozide 1.2.4-triozolo- pyridine [4,3-olpyridin- 3(2H)-one (I)
Trozodone
Reference(s): US 3 381 009 (Angelini Francesco; 30.4.1968; I-prior. 15.12.1965). DE 1 645 947 (Angelini Francesco; appl. 13.12.1966; I-prior. 15.12.1965,3.8.1966).
Formulation(s): cps. 25 mg, 50 mg; f. c. tabl. 100 mg; tabl. 50 mg, 100 mg, 150 mg, 300 mg (as hydrochloride)
Trade Name(s): D: Thornbran (Boehringer I: Trittico (Angelini) Restin (Kanebo) Ing.; 1977) J: Desyrel (Pharmacia & USA: Desyrel (Apothecon; 1982) F: Pragmarel (UPSA); wfm Upjohn)
Tkenbolone acetate ATC: A14 (Trienbolone acetate) Use: anabolic
RN: 10161-34-9 MF: C2,1HM03 MW: 3 12.41 EINECS: 233-432-5 CN: (170)-17-(acety1oxy)estra-4,9,11-trien-3-one trenbolone RN: 10161-33-8 MF: C18H2202 MW. 270.37
0 A CH,
178-benzoyloxy-3-chloro-5-0x0- acetic 4,s-seco-2,9(10)-estradiene anhydride (I) 2092 T Trenbolone hexahydrobenzyl carbonate
LiBr, Li2CO3, DMF
H3c -lithium carbonote
3. I , pyridine b 1. tert-arnyl alcohol. sodium
Reference(s): FR-M 1 958 (Roussel-Uclaf; appl. 13.7.1962). GB 1 035 683 (Roussel-Uclaf; valid from 19.4.1963; F-prior. 20.4.1962). Velluz, L. et al.: C. R. Hebd. Seances Acad. Sci. (COREAF) 257,569 (1963). starting material: Velluz, L. et al.: C. R. Hebd. Seances Acad. Sci. (COREAF) 250, 1084 (1960). alternative syntheses: Heker, M. et al.: Steroids (STEDAM) 10,211 (1967). US 3 453 267 (Roussel-Uclaf; 1.7.1969; F-prior. 3 1.12.1964,25.2.1965, 24.3.1965, 14.6.1965, 3.9.1965, 17.9.1965). use for treatment of varicose wounds: DOS 2 119 096 (Roussel-Uclaf; appl. 20.4.1971).
F~rmulation(s): pellet 300 mg
Trade Name(s): F: Finaject (Distrivet); wfm Finaplix (Distrivet); wfm Parabolan (Negma); wfm
Trenbolone hexahydrobenzyl carbonate ATC: ~14 Use: anabolic
RN: 23454-33-3 MF: C26H3404 MW: 410.55 EINECS: 245-669-1 CN: (17~)-17-[[(cyclohexylmethoxy)carbonyl]oxy]estra-4,9,ll-trien-3-one
trenbolone cyclohexylrnethyl Trenbolone hexahydrobenzyl corbonate chloroformate Trengestone T 2093
Referencefs): FR-M 5 979 (Roussel-Uclaf; appl. 17.11.1966).
Formulation(s): amp. 50 mg
Trade Name(s): F: Hexabolan (Phartec); wfm Parabolan (Negma); wfm
Trengestone ATC: GO3 Use: progestogen
RN: 5192-84-7 MF: C2,H25C102 MW: 344.88 EINECS: 225-978-8 CN: (9~,1Oa)-6-chloropregna-1,4,6-triene-3,20-dione
HCI, CHCI,
perbenzoic acid
CI CI
_____,NC CN 2.3-dichloro-5.6- dicyono- 1.4- CI benzoquinone CI 0) Trengestone
Reference (s): US 3 422 122 (North American Philips; 14.1.1969; prior. 7.10.1966,25.9.1964, 12.6.1962; GB-prior. 29.6.1964). BE 652 597 (Philips Gloeilampenfabrieken; appl. 2.12.1964; GB-prior. 29.6.1964).
Trade Name(s): USA: Retrone (Hoffmann-La Roche); wfm lketinoin ATC: DlOADOl; LOlXX14 (Retinoic acid; Vitamin-A acid) Use: acne therapeutic, keratolytic
RN: 302-79-4 MF: C2"H2,02 MW: 300.44 EINECS: 206-129-0 LD,,,: 92 mg/kg (M, i.v.1; 780 mglkg (M, p.0.); 78 mglkg (R, i.v.); 1960 mg/kg (R, p.0.) CN: (aII-E)-3,7-dimethyl-9-(2,6,6-trimethyl-l-cyclohexen-1-yl)-2,4,6,8-nonatetraenoicacid 2094 T Tretoquinol
triphenyl- phosphine
ethyl 3-formyl- vitomin A acid ethyl ester (II) crotonate
I Tretinoin I
(cf. retinol synthesis according to BASF)
Reference(s): DE 1 035 647 (BASF; appl. 17.1.1957). US 3 006 939 (BASF; 31.10.1961; D-pnor. 17.1.l957). Pommer, H.: Angew. Chem. (ANCEAD) 72,811 (1960); 89,437 (1977). Konlg, H. et a].: Arzneim.-Forsch. (ARZNAD) 24, 1184 (1974).
Formulation(s): cream 25 mg/100 g, 50 mg/IOOg, 100 mg/100 g; cps. 10 mg; gel 25 mgI100 g, 50 mg/100 g; sol. 50 mg/100 ml, 100 mg/100 ml
Trade Name(s): D: Cordes VAS (Ichthyol) Locacid (Pierre Fabre I: Airol (Roche) Epi-Aberel (Janssen- Dermatologie) Apsor (ID1)-comb. Chemie) Retacnyl (Galderma) Retin-A (Janssen-Cilag) Eudyna (Knoll) Retin A (Janssen-Cilag) Tretionina (Savoma) Vesanoid (Roche) Retinova (Roc) Vesanoid (Roche) F: Aberel (Janssen-Cilag) Retitop (La Roche-Posay) J: Vesanoid (Nippon Roche) Antibio-aberel (Janssen- Roaccutane (Roche) USA: Avita (Penederm) Ci1ag)-comb. TrCtinoi'ne KCfrane (Roc) Renova (Ortho Effederm (CS) Vesanoid (Roche) Dermatological) Isotrex (Stiefel) GB: Retin-A (Janssen-Cilag) Retin-A (Ortho Kerlocal (Pierre Fabre) Retinova (Janssen-Cilag) Dermatological) KCtrel (Biorga) Vesanoid (Roche) Vesanoid (Roche)
Tretoquinol ATC: R03AC09; R03CC09 (Trimethoquinol) Use: bronchodilator
RN: 30418-38-3 MF: CIPH2,N05 MW: 345.40 CN: (S)-l,2,3,4-tetrahydro- I-[(3,4,5-trimethoxyphenyl)methyl]-6,7-isoquinolinediol C Triamcinolone T 2095
hydrochloride RN: 18559-59-6 MF: C,,H,NO,. HC1 MW: 381.86 EINECS: 242-423-5 LD,,,: 120 mglkg (M, i.v.); 2250 mglkg (M, p.0.); 164 mglkg (R, i.v.); 2 g/kg (R, p.0.); 160 mg/kg (dog, i.v.)
dopom~nehydrochloride 3-(3.4,5-trimethoxy- (q 4 pheny1)glycidic acid sodium salt
____,(+)-tartaric ocid
HO (+)-lretoquinol (I) 1 Tretoquinol
GB 1 114 660 (Tanabe Seiyaku; appl. 5.12.1966; I-prior. 8.12.1965, 9.6.1966, 22.7.1966). ZA 6 802 416 (Tanabe Seiyaku; 11.9.1968; J-prior. 27.4.1967).
Formulation(s): powder 1 %, tabl. 3 mg; vial 0.1 mg (as hydrochloride)
Trade Name(s): I: Vems (ISF); wfm Vems (Searle); wfm J: Inolin (Tanabe)
Triamcinolone ATC: AOlAC01; D07AB09; D07BB03; D07CBOI; D07XB02; H02ABO8; S01BA05; S02CA04 Use: glucocorticoid
RN: 124-94-7 MF: C21H27F06 MW: 394.44 EINECS: 204-718-7 LD,,,: >4 gkg (M, s.c.); 99 mgkg (R, s.c.) CN: (1 1~,16a)-9-fluoro-l1,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 2096 T Triamcinolone
1. SOCIZ, pyridine 2. KOH
cortisol 21 -acetate ethylene glycol
oso pyridine 4 I1 osmium .acetic anhydride tetroxide
0 H,C-CO-NH-Br. HCIO, CH3COOK Irl
acetamide 0' (10
simplex A IV hydrogen fluoride 0
0
Triomcinolane
OwoH I. Arthrobocter simplex (ATK 6946) do2. Streptomyces raseachromogenes (~llC13400) F H 0 fludrocortisone (q v.) Triamcinolone acetonide T 2097
Reference(s): a US 2 789 1 18 (American Cyanamid; 16.4.1957; prior. 30.3.1956). Bernstein, S. et al.: J. Am. Chem. Soc. (JACSAT) 78, 5693 (1956). Bernstein, S. et al.: J. Am. Chem. Soc. (JACSAT) 81, 1689 (1959). b US 3 536 586 (Squibb; 27.1 0.1970; prior. 25.1.1958).
Forrnulation(s): tabl. 2 mg, 4 mg, 8 mg, 16 mg
Trade Name(s): D: Berlicort (Berlin-Chemie) Ipercortis (AGIPS) Ledercort P8 (Wyeth- Delphicort Tabl. (Lederle) Kenacort-A Retard Lederle) Triam-oral4 (Sanorania) (Bristol-Myers Squibb) combination preparations Volon Tabl. (Bristol-Myers Ledercort (Wyeth-Lederle) J: Kenacort (Squibb-Sankyo) Squibb) Ledercort ,4110 (Wyeth- Ledercort (Lederle) GB: Ledercort (Lederle); wfm Lederle) USA: Aristocort (Fujisawa) I: Dirahist (Teofarma)-comb.
Triamcinolone acetonide ATC: D07AB09 Use: glucocorticoid
RN: 76-25-5 MF: C24H31F0, MW: 434.50 EINECS: 200-948-7 LD,,: 5 glkg (M, p.0.) CN: (1 lP.l6a)-9-fluoro-11.2 1-dihydroxy- 16,17-[(I -methylethylidene)bis(oxy)Jpregna-1,4-diene-3.20-dione
triarncinolone acetone Triamcinolone acetonide
Reference(s): US 2 990 401 (American Cyanamid; 27.6.1961; appl. 18.6.1958; prior. 11.3.1958). Bernstein, S. et al.: J. Am. Chem. Soc. (JACSAT) 81, 1689 (1959). Heller, M. et al.: J. Org. Chem. (JOCEAH) 26, 5044 (1961). Fried, J. et al.: J. Am. Chem. Soc. (JACSAT) 80,2338 (1958).
Fomtulation(s): amp. 40 mglml; cream 1 mglg; ointment 1 mg/g; spray 3 mgl25 g; susp. 10 mglml, 40 mglml
Trade Name(s): D: Arutrin (Chauvin Triam Creme Lichtenstein Corticotulle Lumkre ankerpharm) (Lichtenstein) (Solvay Pharma)-comb. Berlicort (Berlin-Chemie) Triamgalen (Pharmagalen) Kenacort-retard (Bristol- Delphicort CremeISalbe Triamhexal (Hexal) Myers Squibb) (I ~derle) Triam-Injekt (Sanorania) Kenalcol (Bristol-Myers Extracort Creme Tri-Anemul (Medopharm) Squibb)-comb. (Galderma) Volon (Bristol-Myers Localone (Pierre Fabre Kenalog (Bristol-Myers Squibb) Dermato1ogie)-comb. Squibb) Volonimat (Bristol-Myers Mycolog (Bristol-Myers Korticoid ratiopharm Squibb) Squibb)-comb. (ratiopharm) combination preparations Nasacort (Specia) Triamcinolon Wolff (Wolff) F: Cidermex (Evans Medical)- Pevisone (Janssen-Ci1ag)- comb. comb.