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Kv2.1/KCNB1 Polyclonal Antibody Catalog # AP74298

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Kv2.1/KCNB1 Polyclonal Antibody Catalog # AP74298 10320 Camino Santa Fe, Suite G San Diego, CA 92121 Tel: 858.875.1900 Fax: 858.622.0609 Kv2.1/KCNB1 Polyclonal Antibody Catalog # AP74298 Specification Kv2.1/KCNB1 Polyclonal Antibody - Product Information Application WB Primary Accession Q14721 Reactivity Human, Mouse, Rat Host Rabbit Clonality Polyclonal Kv2.1/KCNB1 Polyclonal Antibody - Additional Information Gene ID 3745 Other Names Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (h-DRK1) (Voltage-gated potassium channel subunit Kv2.1) Dilution WB~~WB 1:500-2000, ELISA 1:10000-20000 Format Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Conditions -20℃ Kv2.1/KCNB1 Polyclonal Antibody - Protein Information Name KCNB1 (HGNC:6231) Kv2.1/KCNB1 Polyclonal Antibody - Background Function Voltage-gated potassium channel that mediates transmembrane potassium Voltage-gated potassium channel that transport in excitable membranes, primarily mediates transmembrane potassium transport in the brain, but also in the pancreas and in excitable membranes, primarily in the brain, cardiovascular system. Contributes to the but also in the pancreas and cardiovascular regulation of the action potential (AP) system. Contributes to the regulation of the repolarization, duration and frequency of action potential (AP) repolarization, duration repetitive AP firing in neurons, muscle cells and frequency of repetitive AP firing in and endocrine cells and plays a role in neurons, muscle cells and endocrine cells and Page 1/5 10320 Camino Santa Fe, Suite G San Diego, CA 92121 Tel: 858.875.1900 Fax: 858.622.0609 homeostatic attenuation of electrical plays a role in homeostatic attenuation of excitability throughout the brain electrical excitability throughout the brain (PubMed:<a href="http://www.uniprot.org/c (PubMed:23161216). Plays also a role in the itations/23161216" regulation of exocytosis independently of its target="_blank">23161216</a>). Plays electrical function (By similarity). Forms also a role in the regulation of exocytosis tetrameric potassium- selective channels independently of its electrical function (By through which potassium ions pass in similarity). Forms tetrameric potassium- accordance with their electrochemical selective channels through which potassium gradient. The channel alternates between ions pass in accordance with their opened and closed conformations in response electrochemical gradient. The channel to the voltage difference across the alternates between opened and closed membrane. Homotetrameric channels mediate conformations in response to the voltage a delayed-rectifier voltage-dependent outward difference across the membrane. potassium current that display rapid activation Homotetrameric channels mediate a delayed-rectifier voltage-dependent and slow inactivation in response to membrane outward potassium current that display depolarization (PubMed:8081723, rapid activation and slow inactivation in PubMed:1283219, PubMed:10484328, response to membrane depolarization PubMed:12560340, PubMed:19074135, (PubMed:<a href="http://www.uniprot.org/c PubMed:19717558, PubMed:24901643). Can itations/8081723" form functional homotetrameric and target="_blank">8081723</a>, heterotetrameric channels that contain PubMed:<a href="http://www.uniprot.org/ci variable proportions of KCNB2; channel tations/1283219" properties depend on the type of alpha target="_blank">1283219</a>, subunits that are part of the channel (By PubMed:<a href="http://www.uniprot.org/ci similarity). Can also form functional tations/10484328" heterotetrameric channels with other alpha target="_blank">10484328</a>, subunits that are non-conducting when PubMed:<a href="http://www.uniprot.org/ci expressed alone, such as KCNF1, KCNG1, tations/12560340" KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, target="_blank">12560340</a>, KCNS2, KCNS3 and KCNV1, creating a PubMed:<a href="http://www.uniprot.org/ci functionally diverse range of channel tations/19074135" complexes (PubMed:10484328, target="_blank">19074135</a>, PubMed:11852086, PubMed:12060745, PubMed:<a href="http://www.uniprot.org/ci PubMed:19074135, PubMed:19717558, tations/19717558" PubMed:24901643). Heterotetrameric channel target="_blank">19717558</a>, activity formed with KCNS3 show increased PubMed:<a href="http://www.uniprot.org/ci current amplitude with the threshold for action tations/24901643" potential activation shifted towards more target="_blank">24901643</a>). Can form functional homotetrameric and negative values in hypoxic-treated pulmonary heterotetrameric channels that contain artery smooth muscle cells (By similarity). variable proportions of KCNB2; channel Channel properties are also modulated by properties depend on the type of alpha cytoplasmic ancillary beta subunits such as subunits that are part of the channel (By AMIGO1, KCNE1, KCNE2 and KCNE3, slowing similarity). Can also form functional activation and inactivation rate of the delayed heterotetrameric channels with other alpha rectifier potassium channels (By similarity). In subunits that are non-conducting when vivo, membranes probably contain a mixture of expressed alone, such as KCNF1, KCNG1, heteromeric potassium channel complexes, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, making it difficult to assign currents observed KCNS2, KCNS3 and KCNV1, creating a in intact tissues to any particular potassium functionally diverse range of channel channel family member. Major contributor to complexes (PubMed:<a href="http://www.u the slowly inactivating delayed-rectifier niprot.org/citations/10484328" voltage- gated potassium current in neurons of target="_blank">10484328</a>, the central nervous system, sympathetic PubMed:<a href="http://www.uniprot.org/ci ganglion neurons, neuroendocrine cells, tations/11852086" pancreatic beta cells, cardiomyocytes and Page 2/5 10320 Camino Santa Fe, Suite G San Diego, CA 92121 Tel: 858.875.1900 Fax: 858.622.0609 target="_blank">11852086</a>, smooth muscle cells. Mediates the major part PubMed:<a href="http://www.uniprot.org/ci of the somatodendritic delayed-rectifier tations/12060745" potassium current in hippocampal and cortical target="_blank">12060745</a>, pyramidal neurons and sympathetic superior PubMed:<a href="http://www.uniprot.org/ci cervical ganglion (CGC) neurons that acts to tations/19074135" slow down periods of firing, especially during target="_blank">19074135</a>, high frequency stimulation. Plays a role in the PubMed:<a href="http://www.uniprot.org/ci induction of long-term potentiation (LTP) of tations/19717558" neuron excitability in the CA3 layer of the target="_blank">19717558</a>, hippocampus (By similarity). Contributes to the PubMed:<a href="http://www.uniprot.org/ci regulation of glucose-induced action potential tations/24901643" amplitude and duration in pancreatic beta target="_blank">24901643</a>). cells, hence limiting calcium influx and insulin Heterotetrameric channel activity formed secretion (PubMed:23161216). Plays a role in with KCNS3 show increased current amplitude with the threshold for action the regulation of resting membrane potential potential activation shifted towards more and contraction in hypoxia-treated pulmonary negative values in hypoxic- treated artery smooth muscle cells. May contribute to pulmonary artery smooth muscle cells (By the regulation of the duration of both the similarity). Channel properties are also action potential of cardiomyocytes and the modulated by cytoplasmic ancillary beta heart ventricular repolarization QT interval. subunits such as AMIGO1, KCNE1, KCNE2 Contributes to the pronounced pro-apoptotic and KCNE3, slowing activation and potassium current surge during neuronal inactivation rate of the delayed rectifier apoptotic cell death in response to oxidative potassium channels (By similarity). In vivo, injury. May confer neuroprotection in response membranes probably contain a mixture of to hypoxia/ischemic insults by suppressing heteromeric potassium channel complexes, pyramidal neurons hyperexcitability in making it difficult to assign currents hippocampal and cortical regions (By observed in intact tissues to any particular similarity). Promotes trafficking of KCNG3, potassium channel family member. Major KCNH1 and KCNH2 to the cell surface contributor to the slowly inactivating membrane, presumably by forming delayed- rectifier voltage-gated potassium heterotetrameric channels with these subunits current in neurons of the central nervous (PubMed:12060745). Plays a role in the system, sympathetic ganglion neurons, calcium-dependent recruitment and release of neuroendocrine cells, pancreatic beta cells, fusion-competent vesicles from the soma of cardiomyocytes and smooth muscle cells. neurons, neuroendocrine and glucose- induced Mediates the major part of the pancreatic beta cells by binding key somatodendritic delayed-rectifier potassium components of the fusion machinery in a current in hippocampal and cortical pore-independent manner (By similarity). pyramidal neurons and sympathetic superior cervical ganglion (CGC) neurons that acts to slow down periods of firing, especially during high frequency stimulation. Plays a role in the induction of long-term potentiation (LTP) of neuron excitability in the CA3 layer of the hippocampus (By similarity). Contributes to the regulation of glucose-induced action potential amplitude and duration in pancreatic beta cells, hence limiting calcium influx and insulin secretion (PubMed:<a href="http://www.uniprot.org/c itations/23161216" target="_blank">23161216</a>). Plays
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