Curriculum vitae Scott B. Selleck

Contact Information Department of Biochemistry & Molecular Biology, The Pennsylvania State University 206D Life Science Bldg, University Park, PA 16802 Tel: 814-863-4655 (office); cell: 612-868-4444 Email: [email protected]; [email protected] (personal)

Education B.A. (Zoology), summa cum laude, 1979. University of Washington, Seattle, WA.

M.D./Ph.D. (Molecular Biology) 1981-89. Washington University School of Medicine.

Postdoctoral Training Dept. of Brain and Cognitive Sciences, M.I.T., 1989-90. Laboratory of Dr. Hermann Steller.

Dept. of Biology, Brandeis University, 1990-1993. Laboratory of Dr. Kalpana White.

Professional Experience Assistant Professor, Dept. of Molecular & Cellular Biology and Division of Neurobiology, University of Arizona, 3/93-8/99. Associate Professor with tenure, Dept. of Molecular & Cellular Biology, University of Arizona, 8-99-2002. Director, Master’s Program in Applied Biosciences (2000-01), U. of Arizona (wrote and was awarded grant from the Sloan Foundation). Director, Program in Molecular Genetics, Arizona Cancer Center, University of Arizona, 7/00- 9/02. Professor, Director and Harrison Land Grant Endowed Chair, The Developmental Biology Center, The University of Minnesota, Depts. of Pediatrics and Genetics, Cell Biology, & Development, 9/02-9/09. Director, The University of Minnesota Autism Initiative, 2007-2009. Professor and Head, Department of Biochemistry & Molecular Biology, The Pennsylvania State University (8/09-7/2017) Current Position: Professor of Biochemistry & Molecular Biology, Eberly College of Science with joint appointment in the Penn State College of Medicine

Honors and Awards Phi Beta Kappa, University of Washington, 1979. Medical Scientist Training Program (M.D./Ph.D.) NIH Fellowship, Washington University School of Medicine, 1981-1988. Spencer T. and Ann W. Olin Medical Scientist Fellow, Washington University School of Medicine, 1989. Life Sciences Research Foundation Postdoctoral Fellowship, 1989-1992. Burroughs Wellcome Travel Grant Award for U.S.-Great Britain Exchange, 1990. NIH Postdoctoral Training Grant, 1992-93. Alfred P. Sloane Foundation Research Fellowship for Young Investigators, 1994-96. Basil O'Connor Young Investigator Award, March of Dimes, 1995-97. Martin Lenz Harrison Land Grant Chair in Pediatrics, University of Minnesota, 2002-2009.

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Publications Papers in refereed journals Selleck, S.B. and Simpson, J.B. (1980). Intracranial injection parameters which affect angiotensin-II induced drinking. Pharmacol. Biochem. Behav. 13: 581-584.

Fantel, A.G., Greenaway, J.C., Shepard, T.H., Juchau, M.R., and Selleck, S.B. (1981). The teratogenicity of cytochalasin D and its inhibition by drug metabolism. Teratology 23:223-231.

Selleck, S.B., Elgin, S.C.R., and Cartwright, I.L. (1984). Supercoil-dependent features of DNA structure at Drosophila locus 67B1. J. Mol. Biol. 178:17-33.

Selleck, S.B., and Majors, J. (1987). Photofootprinting in vivo detects transcription dependent changes in yeast TATA boxes. Nature 325:173-177.

Selleck, S.B., and Majors, J. (1987). In vivo DNA binding properties of a yeast transcription- activator protein. Mol. Cell. Biol. 7:3260-3267.

Selleck, S.B., and Majors, J. (1988). In vivo photofootprint changes at sequences between the yeast GAL1 UASG and TATA require activated GAL 4 protein but not a functional TATA element. Proc Nat Acad Sci USA 85:5399-5403.

Selleck, S.B. and Steller, H. (1991). The influence of retinal innervation on neurogenesis in the first optic ganglion of Drosophila. Neuron 6:83-99.

Selleck, S.B., Gonzalez, C., Glover, D., and White, K. (1992). Regulation of the G1-S transition in post-embryonic neuronal precursors by axon ingrowth. Nature 355:253-255.

Nakato, H., Futch, T., and Selleck, S.B. (1995). The division abnormally delayed (dally) gene: a putative integral membrane proteoglycan required for cell division patterning during post- embryonic development of the nervous system in Drosophila. Development 121:3687-3702.

Manseau,. L., Baradaran, A., Brower, D., Budhu, A., Elefant, F., Glover, D., Kaiser, K., Palter, K., Phan, H., Philp, A., Yang, M., and Selleck, S. (1997). GAL4 enhancer traps expressed in the embryo, larval brain, imaginal discs, and ovary of Drosophila. Developmental Dynamics 209: 310- 322.

Penton, A., Selleck, S.B., and Hoffmann, F.M. (1997). Regulation of cell cycle synchronization by decapentaplegic during Drosophila eye development. Science 275:203-206.

Jackson, S.M., Nakato, H., Sugiura, M., Jannuzi, A., Oakes, R., Kaluza, V., Golden, C., and Selleck, S.B. (1997). division abnormally delayed, a Drosophila glypican, controls cellular responses to the TGF-ß-related morphogen, Dpp. Development 124: 4113-4120.

Tsuda, M., Kamimura, K., Nakato, H., Archer, M., Staatz, W., Fox, B., Humphrey, M., Olson, S. Siegfried, E., Stam, L., and Selleck, S.B. (1999). A cell surface proteoglycan, Dally, regulates Wingless signaling in Drosophila. Nature 400:276-280.

Toyoda, H., Kinoshita-Toyoda, A., and Selleck, S.B. (2000). Structural analysis of glycosaminoglycans in Drosophila melanogaster and C. elegans and demonstration that tout-velu, a Drosophila gene related to EXT tumor suppressors, affects heparan sulfate in vivo. J. Biol. Chem. 275: 2269-2275. Curriculum Vitae: Scott B. Selleck p. 3

Toyoda, H., Kinoshita-Toyoda, A., Fox, B., and Selleck, S. B. (2000). Structural Analysis of Glycosaminoglycans in Animals Bearing Mutations in sugarless, sulfateless, and tout-velu. Drosophila homologues of vertebrate genes encoding glycosaminoglycan biosynthetic enzymes. J Biol Chem 275: 21856-21861.

Bulik, D. A., Wei, G., Toyoda, H., Kinoshita-Toyoda, A., Waldrip, W. R., Esko, J. D., Robbins, P. W., and Selleck, S. B. (2000). sqv-3, -7, and -8, a set of genes affecting morphogenesis in C. elegans encode enzymes required for glycosaminoglycan biosynthesis. Proc Nat Acad Sci (USA)97:10838-43.

Fujise, M., Izumi, S., Selleck, S.B., and Nakato, H. (2001). dally, a Drosophila integral membrane proteoglycan selectively participates in Wingless or Dpp signaling in the specification of adult sensory bristles. Dev Biol. 235(2):433-48.

Nakato, H., Fox, B., and Selleck, S.B. (2002). dally, a Drosophila member of the glypican family of integral membrane proteoglycans, affects cell cycle progression and morphogenesis via a Cyclin A-mediated process. J. Cell Sci. 115: 123-130.

Rawson, J., Lee, M., and Selleck, S.B. (2003). Drosophila neuromuscular synapse assembly and function require the TGF-β type I receptor Saxophone and the transcription factor Mad. J Neurobio 55(2):134-150.

Bornemann, D.J., Duncan, J.E., Staatz, W., Selleck, S.B. and Warrior, R. (2004). Abrogation of heparan sulfate synthesis in Drosophila disrupts Wingless, Hedgehog and Decapentaplegic signaling pathways. Development 131(9):1927-38.

Kirkpatrick, C . Dimitroff, B,. Rawson, J. and Selleck, S.B. (2004) Dally-like, a Drosophila glypican, controls the distribution and signaling of the Wingless morphogen. Dev. Cell. 7(4): 513-523.

Ledin, J., Staatz, W., Gotte, M., Selleck, S.B., Kjellen, L., and Spillmann, D. (2004). Heparan sulfate structure in mice with genetically modified heparan sulfate production. J Biol Chem 279(41):42732-42741.

Lee, J-S., von der Hardt, S., Rusch, M.*, Stringer, S.*, Stickney, H., Talbot, W, Geisler, R., Nusslein- Volhardt, C., ., Selleck, S.B., Chien, C-B., and Roehl, H. Axon sorting in the optic tract requires HSPG synthesis by EXT2/dackel and EXTL3/boxer. Neuron. 44(6):947-60.*Selleck lab contributors

Rawson, J. M., Johnson, K. B., Ge, X., Van Vactor, D., and Selleck, S. B. (2005). The Heparan Sulfate Proteoglycans Dally-like and Syndecan Have Distinct but Overlapping Functions in Axon Guidance and Visual System Assembly in Drosophila. Curr Biol 15(9):833-838.

Chen, E., Stringer, S.E, Rusch2, M.A., Selleck, S.B.* and Ekker, S.E.* (2005). A Unique Role for 6-O Sulfation Modification in Zebrafish Vascular Development. Dev Biol 284(2):364-76. *joint corresponding authors.

Pan, C., Nelson, M.S., Reyes, M., Koodie, L., Brazil, J.L., Stephenson, E.J., Zhao, R.C., Peters, C., Selleck, S.B., Stringer, S.E., Gupta, P. (2005). Functional abnormalities in heparan sulfate mucopolysaccharidosis-1 are associated with defective biological activity of FGF-2 on human multipotent progenitor cells. Blood 106(6):1956-64.

Kirkpatrick C.A., Knox S.M., Staatz W.D., Fox B., Lercher D.M., Selleck, S.B. (2006). The function of a Drosophila glypican does not depend entirely on heparan sulfate modification. Dev Biol. Curriculum Vitae: Scott B. Selleck p. 4

300: 570-582

Balciuniene*, J. Feng*, N-P., Iyadurai, K. , Hirsch, B., Charnas, L., Bill, B., Staaf, J., Oseth L., Roberts, W., Avramopoulos, D., Borg Å, Valle, D., Schimmenti, L., Selleck,, S.B. (2007). Recurrent 10q22- 23 deletions: a genomic disorder on 10q associated with Cognitive and Behavioral Abnormalities AJHG 80(5):938-47. * contributed equally

Knox,S. M.* , Ge,H.*, Dimitroff, B.D., Mitschele, K., Arsham, A. M., Neufeld,T. P., & O’Connor, M., Selleck, S. B. (2007) Mechanisms of TSC-mediated Control of Synapse Assembly and Axon Guidance PLoS ONE Apr 18;2:e375. * contributed equally.

Dasgupta, U., Dixit, B.L., Rusch, M., Selleck, S.B., The, I. (2007). Functional conservation of the human EXT1 tumor suppressor gene and its Drosophila homolog tout velu. Dev. Genes & Evo. 217(8):555-61.

Sun, M., Thomas, M.J., Herder, R., Selleck, S.B., and O’Connor, M.B. (2007). Presynapatic contributions of Chordin to hippocampal plasticity and spatial learning. J. Neuroscience 27(29):7740-50.

Clement, A., Wiweger, M., von der Hardt, S., Rusch, M.A., Selleck, S.B., Chien, C.B., Roehl, H.H. (2008). Regulation of skeletal morphogenesis by sulphated proteoglycans in Danio rerio, PLoS Genetics Jul 25;4(7):e1000136.

Adhikari,N., Rusch, M., Mariash, A., Li, Q., Selleck, S.B. and Hall, J.L. (2008) Alterations in Heparan sulfate in the Vessel in response to Vascular Injury in the Mouse. J. Cardiovascular Trans Res :1, (3), pp. 236-240.

Ren, Y., Kirkpatrick, C.A., Rawson, J. Sun, M., and Selleck, S.B. (2009). Cell-type specific requirements for heparan sulfate biosynthesis at the Drosophila NMJ: effects on synapse function, membrane trafficking and mitochondrial localization J. Neurosci. 29(26):8539-8550.

Buresh RA, Kuslak SL, Rusch MA, Vezina CM, Selleck SB, Marker PC. (2010). Sulfatase 1 Is an Inhibitor of Ductal Morphogenesis with Sexually Dimorphic Expression in the Urogenital Sinus. Endocrinology. 2010 Apr 21. [Epub ahead of print]

Adhikari, N., Basi, D.L., Rusch, M., Mariash, A., Mullegama, S., Watson, A., Larson, J., Tan, S., Lerman, B, Esko, J.D., Selleck, S.B., Hall, J.L. (2010). Heparan Sulfate Ndst1 Regulates Vascular Smooth Muscle Cell Proliferation, Vessel Size and Vascular Remodeling. J Mol Cell Cardiol. Aug;49(2):287-93. Epub 2010 Mar 4. PubMed PMID: 20206635; PubMed Central PMCID: PMC2885463.

Ashley Smart1, Meredith M. Course1, Joel Rawson2, Scott Selleck3, David Van Vactor4, and Karl G. Johnson. (2011). Heparan sulfate proteoglycan specificity during axon pathway formation in the Drosophila embryo. Developmental Neurobiology. 2011 Jul;71(7):608-18. doi: 10.1002/dneu.20854. PMID:21500363

B.W.M. van Bon*1, J. Balciuniene*2, G. Fruhman*3, S.C.S. Nagamani3, D.L. Broome4, E. Cameron5, D. Martinet6, S. Jacquemont6, J. Beckmann6, M. Irons7, L. Potocki3, B. Lee3,8,9 , S.W. Cheung3, A. Patel3, N.V. Knoers1, N. de Leeuw1, R. Pfundt1, B. Wolf5, P. Jira10, S. Aradhya11, P. Stankiewicz3, H.G. Brunner1, O. Zuffardi12, S.B. Selleck13, §, J.R. Lupski3,8,9, B.B.A. de Vries1. (2011). The phenotype of recurrent 10q22q23 deletions and duplications. Eur J Hum Genet. Apr;19(4):400-8. doi: 10.1038/ejhg.2010.211. Epub 2011 Jan 19.

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Dimitroff, B., Howe, K., Watson, A., Campion, B., Lee, H-G, Zhao, N., O’Connor, M, Neufeld, T., and Selleck, S.B. (2012). Diet and energy-sensing inputs affect TorC1-mediated axon misrouting but not TorC2-directed synapse growth in a Drosophila model of tuberous sclerosis. PLoS ONE 7(2):e30722.

Lee, H-G, N Zhao, BK Campion, M Nguyen, and SB Selleck. (2012). Akt regulates glutamate receptor trafficking and postsynaptic membrane elaboration at the Drosophila neuromuscular junction. Dev Neurobiol. 2013 Oct;73(10):723-43. doi: 10.1002/dneu.22086. Epub 2013 Aug 20

Girirajan, S, RL Johnson, , F Tassone, J Balciuniene, N Katiyar, K Fox, C Baker, A Srikanth, K-H Yeoh, SJ Khoo, TB Nauth, R Hansen, M Ritchie, I Hertz-Picciotto, EE Eichler, IN Pessah, SB Selleck (2012). Global increases in both common and rare copy number load associated with autism. Hum Mol Genet. 2013 Jul 15;22(14):2870-80. doi: 10.1093/hmg/ddt136. Epub 2013 Mar 27.

He BZ, Ludwig MZ, Dickerson DA, Barse L, Arun B, Vilhjálmsson BJ, Park SY, Tamarina NA, Selleck SB, Wittkopp PJ, Bell GI, Kreitman M. Effect of Genetic Variation in a Drosophila Model of Diabetes-Associated Misfolded Human Proinsulin. Genetics. 2013 Nov 26. [Epub ahead of print]

Ciesielski TH, Pendergrass SA, White MJ, Kodaman N, Sobota RS, Selleck, SB, et al. (2014) Diverse convergent evidence in the genetic analysis of complex disease: coordinating omic, informatic, and experimental evidence to better identify and validate risk factors. BioData Min 7: 10.

Reynolds-Peterson, C.E., Zhao†, N. Xu, J. Serman, T.M. Xu, J-l., and Selleck, S.B. (2017). Heparan Sulfate Proteoglycans Regulate Autophagy in Drosophila. Autophagy. Apr 12:1-18. doi: 10.1080/15548627.2017.1304867.

Kim, D., Volk, Girirajan, S., Pendergrass, S., Hall, M., Verma,, S.S., Schmidt, R.J., Hansen, R.., Ghoshf, D., Hertz-Picciotto, I., Ritchie,M.D., and Selleck, S.B. (2017). Interactions between air pollution exposure and copy number variation confer significant risk for autism. Autism Research. Apr 27. doi: 10.1002/aur.1799.

Invited Review Articles Selleck, S.B. (1999) The role of heparan sulfate-modified proteoglycans in growth control and morphogenesis during development. Matrix Biology 17: 473-476.

Selleck, S.B., (1999). Overgrowth syndromes and the regulation of signaling complexes by proteoglycans. Am. J. Hum. Genet. 64: 372-377.

Lander. A., and Selleck, S.B (2000). The Elusive Functions of Proteoglycans: In Vivo Veritas J. Cell Biol. 148: 227-232.

Selleck, S.B. (2000). Proteoglycans and pattern formation: sugar biochemistry meets developmental genetics. Trends in Genetics 16, 206-212.

Selleck, S.B. (2001). Genetic dissection of proteoglycan function. Seminars in Cell & Developmental Biology. 12: 127-134.

Filmus, J. and Selleck, S.B. (2001). Glypicans: proteoglycans with a surprise. J. Clin. Invest. 108: 497-501.

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Selleck, S.B., and Esko, J. (2002). Order Out of Chaos: Assembly of Ligand Binding Sites in Heparan Sulfate. Ann. Rev. Biochem. 71:435-471.

Selleck, S.B., and Nakato, H. (2004). Functional dissection of glycoconjugates during development: Lessons from the fruitfly. Trends in Glycoscience and Glycotechnology.

Selleck, S.B. (2006). Shedding light on the distinct functions of proteoglycan. Science STKE Apr 4;2006(329):pe17.

Selleck, S. B. (2006). Signaling from across the way: transactivation of VEGF receptors by HSPGs. Mol Cell 22, 431-2.

Kirkpatrick, C. A. and Selleck, S. B. (2007). Heparan sulfate proteoglycans at a glance. J Cell Sci 120, 1829- 32.

Book Chapters Selleck, S. B., and Majors, J. (1986). Photofootprinting in vivo of the yeast GAL1-10 promoter. In Transcriptional Control Mechanisms, UCLA Symposium on Molecular and Cellular Biology, Vol. 52. Granner D.K., Rosenfeld, G., and Chang, S., eds. Alan R. Liss Inc., New York, N.Y., p 31-44.

Selleck, S.B. (1999). Developmental genetics: tools and strategies. In Cell Surface Proteoglycans in Signaling and Development. Lander, A., Nakato, H., Selleck, S.B., Turnbull, J., and Coath, C. eds. HFSP, Strasbourg.

Selleck, S.B. and Nakato, H. (1999). Function of Dally in Decapentaplegic and Wingless signaling pathways. In Cell Surface Proteoglycans in Signaling and Development. Lander, A., Nakato, H., Selleck, S.B., Turnbull, J., and Coath, C. eds. HFSP, Strasbourg.

Nakato, H., Izumi, S., and Selleck, S.B. (1999). The function of Dally, a Drosophila glypican, in Dpp signaling. In Animal Cell Technology: Basic & Applied Aspects. Kitagawa, Y., Matsuda, T., and Iijima, S., eds. Kluwer Academic Publishers, Dordrecht.

W. D. Staatz, H. Toyoda, A. Kinoshita-Toyoda, K. Chhor and S.B Selleck. (2000) Analysis of proteoglycans and glycosoaminoglycans. Methods in Molecular Biology, Vol.35, Proteoglycan Protocols (R. V. Iozzo, ed) 2000. Humana Press, Clifton, NJ

Selleck, S.B., and S.E. Stringer (2004). Extracellular Matrix and Signaling During Development. In Inborn Errors of Development.Epstein, C.J., Erickson, R.P., and Wynshaw-Boris, A., eds. Oxford University Press, Oxford and New York.

Edited Books and Special Issue Journals “Cell Surface Proteoglycans in Signaling and Development.” Eds. A. Lander, H. Nakato, S.B. Selleck, J.E. Turnbull, and C. Coath. HFSP, Strasbourg, 1999.

“Developmental Glycobiology”. Eds. H. Schacter and S.B. Selleck, Biochemica et Biophysica Acta, Vol 1573, Elsevier, Amsterdam, 2002.

Tiemeyer M, Selleck SB, Esko JD. Arthropoda. In: Varki A, Cummings RD, EskoJD, Freeze HH, Stanley P, Bertozzi CR, Hart GW, Etzler ME, editors. Essentials of Glycobiology. 2nd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009. Chapter 24. PubMed PMID: 20301252.

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Pendergrass S, Girirajan S, Selleck S. Uncovering the etiology of autism spectrum disorders: genomics, bioinformatics, environment, data collection and exploration, and future possibilities. Pac Symp Biocomput. 2014:422-6.

Scholarly Presentations Invited Departmental/Institute Seminars University of Tokyo, Dept. of Biophysics, 1/93 Tokyo Metropolitan University, Dept. of Biology, 1/93. Mitsubishi-Kasei Life Sciences Research Institute, 1/93. Carnegie Mellon University and University of Pittsburgh, Depts. of Biology, 2/93. University of Michigan, Department of Human Genetics, 4/94. Queensland Institute of Medical Research, Brisbane, Australia. 11/94. University of Adelaide, Adelaide, South Australia, 12/94. University of Wisconsin, Dept. of Zoology, 11/95. Fred Hutchinson Cancer Research Center, 3/96. University of California, Irvine, Dept. of Dev. & Cell Biology, 11/96. Brandeis University, Waltham, MA., Dept. of Biology, 6/97 University of Massachusetts, Amherst, MA., Dept. of Biochemistry, 6/97 University of Calgary, Dept. of Biology, 11/97 University of Alberta, 11/97 Mayo Research Institute, Scottsdale, AZ., 2/98. University of Minnesota, Minneapolis, MN. Dept. of Cell Biol. and Development, 10/98. Novartis Inc., Research Triangle Park, N.C., 2/99. University of North Carolina, Chapel Hill. Dept. of Biology, 2/99. University of Cambridge, U.K., Dept. of Genetics, 10/99. University of California, San Diego Medical School, Dept. of Cell & Molecular Medicine, invited speaker, 5/00. The Burham Institute, San Diego, CA. Invited speaker, 10/00. The Eisenhower Medical Center, Palm Springs, CA. Peter Kiewit Memorial Lecture, 4/01. Texas A&M, Dept. of Biochemistry and Biophysics. Invited speaker. 1/02 University of Minnesota, Dept. of Genetics, Cell Biology and Development 2/02 University of Texas, Austin, Depts. of Genetics and Molecular Cellular Biology, 11/02. Chiba University, Japan, 12/02. University of Toronto, Hospital for Sick Children, 10/03 Medical College of Georgia, Augusta, GA. 2/04. Harvard Medical School, Dept. of Cell Biology, 4/04 Oregon Health Science University, Dept. of Molecular Medicine, invited speaker, 5/04. EMBL, Heidelberg, Germany, Developmental Biology group, invited speaker, 5/04. UC San Diego, Cell and Molecular Medicine, Departmental seminar, 5/04. University of Padua, Italy, Dept. of Neurology, invited seminar, 5/04. Lund University, Stem Cell Institute, invited seminar, 9/04. University of Georgia, Complex Carbohydrate Research Center, Athens, GA, 4/05. Texas A&M, Dept. of Biochemistry, College Station, TX, 4/05. Aichi University, Japan, invited speaker 8/05 University of Tokyo, Genome Science Division, Tokyo, Japan, invited seminar speaker, 8/05. Trinity College, Dublin, Ireland. Invited departmental seminar, Genetics, 3/06. University of Wisconsin, Madison. Dept. of Pathology, 2/07. Nimble Gen, Inc. Invited presentation at their research headquarters in Madison, WI. 2/07 and a follow up web-based seminar, available internationally. Mayo Clinic, Genomics Working Group (3/08). “Genetic instability and its copy number variation in autism spectrum disorder” Pennsylvania State University, Dept of Biochemistry, Molecular and Cellular Biology 5/08. "Adventures in human and fly behavioral genetics: from autism to phototaxis and back Curriculum Vitae: Scott B. Selleck p. 8

again”. University of Minnesota, Lessons from the Field Series, Minneapolis, 10/08. “Foundations of Autism”, 11/08. Public presentation to >300 audience members, and video broadcast to more than 30 sites across Minnesota. Bionanosystems, Inc., Philadelphia, PA. “Measuring genomic variation in segmental duplication-rich intervals of the genome, moving beyond array CGH”. February, 09. Invited talk in preparation for collaborative project. Temple University, Philadelphia, PA. “Genetic instability and its contribution to autism spectrum disorder”. Dept. of Biology, 2/09. Albert Einstein University, New York, NY. “The dogmas and surprises of heparan sulfate proteoglycans in developmental patterning”. Invited seminar, 1/10. The Institute of Advanced Studies, Princeton University, “Copy number variation contributions to autism spectrum disorder”, invited seminar, 3/10.

Symposia European Molecular Biology Organization Meeting, Cell Division Control in Drosophila. 6/95. Loch Rannock, Scotland. Invited talk. Genetics Society of America, 5/96. Invited slide presentation for Symposium on Cell Division Control During Development. Belgian National Fund for Scientific Research, Symposium Speaker, University of Gent, 9/96. CGGH Symposium on "Frontiers in Matrix Biology" in Hiroshima Japan, June 20-22, 1998. Invited speaker “Heparan Sulfate Proteoglycans”. Stockholm, Sweden, invited speaker, 4/99. International Conference on Molecular Interactions of Proteoglycans. Kanagawa, Japan. Invited speaker, 8/99. Belgian Society for Cell Biology, “Mechanisms and Controls of Morphogen Signaling”. Leuven, Belgium, 10/99. Invited speaker. Keystone Symposium, “Wnt and ß-catenin signaling in development and disease”, Taos, New Mexico, 3/02, invited plenary speaker. Mizutani Symposium, “Glycoconjugates in systems biology”, Tokyo, Japan, 12/02. Weaver Symposium, “Drug discovery and orphan diseases”, Minneapolis, 6/03. University of Minnesota Autism Symposium, Minneapolis, 4/05. Chromosome copy number variation and human genetic disorders, Toronto, Ontario, 7/05. Functional Glycomics, Shibuyu, Japan, invited plenary speaker, 8/05. Center for Neurobehavioral Development. “Copy number variation and its contribution to autism spectrum disorder”, 11/07. Pacific Symposium on Biocomputing, 1/14, Hawaii. “A fly’s eye view of autism, developmental genetics of a complex disorder”. Lead speaker presentation.

Conferences Annual Drosophila Conference, Genetics Society of America, Chicago, 4/94 invited slide presentation, and submitted separate poster presentation. Annual Drosophila Conference, Genetics Society of America, Atlanta, 4/95. Poster presentation. Proteoglycan Gordon Conference, Invited Plenary Speaker, 6/96. Developmental Biology Gordon Conference, poster presentation. 6/97. Glycobiology, Invited Plenary Speaker, 10/97. Wnt Meeting, Boston, MA. Poster presentation, 1/98. Basal Lamina Gordon Conference, invited plenary speaker, 6/98. Proteoglycan Gordon Conference, participant, 7/98. Human Frontiers Science Program. “Cell Surface Proteoglycans and Growth Factor Signaling During Development”, Organizer and speaker. 5/98. Society for Developmental Biology, Southwest Regional Meeting, invited speaker, 3/99. Proteoglycan Gordon Conference, Invited Plenary Speaker, 7/00 Co-Chair and presenter, Minisymposium on “Proteoglycans and Cell Communication”, Annual Meeting of the American Society for Cell Biology, 12/00. Curriculum Vitae: Scott B. Selleck p. 9

Biochemical Society/British Society for Developmental Biology Symposium 'Glycobiology of Development' at the University of Sussex, Brighton, UK, invited speaker, 12/00. Glycobiology Gordon Conference, 3/01. Invited speaker. Harden Conference on Proteoglycans/University of Manchester, Ambleside, U.K., 8/01, invited speaker. Cell Adhesion and Migration in Inflammation and Cancer, Amsterdam, The Netherlands, 10/01, invited speaker. San Diego Glycobiology Conference, invited speaker. 1/02. Basement Membrane Gordon Conference, invited plenary speaker, 6/02. Proteoglycan Gordon Conference, invited session chair, 7/02. Glycobiology Gordon Conference, invited plenary speaker, 3/03. Proteoglycans and embryonic development, Parma, Italy, invited session chair, 9/03. Experimental Biology Societies, Washington D.C., invited plenary speaker, 4/04 Glycoconjugates in biological systems, Gullmarstrand, Sweden, invited speaker, 8/04. American Society of Biological Chemistry, San Diego, invited plenary speaker, 4/05 Human Genome Meeting, Kyoto Japan, 4/05. Hereditary Multiple Exostoses: Insights into Pathogenesis Conference (in association with the MHE Coalition) Houston 11/05, invited speaker. British Society for Developmental Biology, York, UK, 3/06, invited plenary speaker. Extracellular Glycomatrix in Health and Disease, 6/06, Awaji Island, Hyogo 656-2306 Japan, invited speaker. Basement Membrane Gordon Conference, Tuscany, Italy, 7/06, invited plenary speaker. Proteoglycan Gordon Conference, session chair and invited speaker, 7/06. American Society of Human Genetics. Invited podium presentation.09/06. Society for Neuroscience, 10/07. Abstract. “Dietary rescue of neurodevelopmental and behavioral deficits in a Drosophila model of tuberous sclerosis complex”. Human Genome Variation Meeting, Toronto, Canada. 10/08. “High-Resolution Mapping of Copy Number Variants Within Low Copy Repeat-rich Segments of the Genome and their Association with Autism”, poster presentation. IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS), May, 2009. Session Chair and invited speaker. Society of Toxicology Meeting, Washington, DC 03/11. Invited Speaker. Autism genetics and environmental interactions, a genomics view. Penn State College of Medicine MD/PhD Physician’s Retreat, University Park, PA, invited speaker, “Autism and The Human Genome”, University Park, PA, 09/11 American Association for the Advancement of Science (AAAS) Annual Meeting, Vancouver, Canada, invited symposium speaker, “Autism, Genetic, Epigenetic, and Environmental Factors Influencing Neural Networks”, 02/12 XXth World Congress of Psychiatric Genetics Conference, Hamburg, Germany, invited speaker, “A genomic instability model of a neurodevelopmental disorder: global copy number burden associated with autism”, 10/12 University of Dublin, Trinity College, Dublin, Ireland, invited speaker, Genomic Instability and Neurodevelopmental disorders in children, 10/12 John Snow Biomedical Sciences Seminar Series, University Park, PA, invited speaker, “A New Model for Understanding Neurodevelopmental Disorders in Children Genomic Instability and Autism Spectrum Disorder”, 11/12 Discovery-U: Where Genius Meets Imagination, University Park, PA, Penn State Student organization, invited speaker, “Genomic Instability: A crucible for genetic change underlying neurodevelopmental disorders in children?”, 11/12 Proteoglycan Gordon Conference, Andover, NH, 2016. Heparan sulfate proteoglycans and the regulation of autophagy. Poster presentation selected for short talk, given by my PhD student, Claire Reynolds. Won best poster award. Seven Lakes Proteoglycan Conference, Varese, Italy, 2017. A Drosophila model of multiple sulfatase deficiency shows altered autophagy in the developing CNS. Invited talk. Curriculum Vitae: Scott B. Selleck p. 10

Proteoglycan Gordon Conference, Andover, NH, 2018. Heparan sulfate proteoglycans affect lifespan and responses to oxidative stress via regulation of autophagy. Invited talk.

Past Research Support Alfred P. Sloane Foundation Fellowship (1994-1996)

March of Dimes Basil O’Connor Award (1995-1998)

NIH R01 GM054832 (Selleck, PI) 7/1/95 - 6/30/2012*. Proteoglycans in Growth Factor Signaling and Development *no cost extension in final year, awarded for 4 competitive renewal cycles The overall goals of this project were to understand the function of the Drosophila glypicans Dally and Dally-like in morphogenesis, and the role of heparan sulfate proteoglycans in tissue patterning. Role: PI

U01-CA91290-01 (Selleck, co-PI, Jeffrey D. Esko, PI) 04/01/2001 – 05/31/2005 NIH/NCI “Heparan Sulfate: A Novel Target for Cancer Therapeutics” This project was a sub-contract with the University of California, San Diego. The major goals of this project were to validate the heparan sulfate biosynthetic pathway as a target for cancer drug therapy, to identify new targets in the heparan sulfate biosynthetic pathway; and to identify and characterize inhibitors of heparan sulfate biosynthesis. Role: PI on Sub-Contract

March of Dimes (Selleck, PI) 06/01/2002 – 05/31/2006 “Growth Factor Regulation of Synapse Development” The major goal of this research was to determine how growth factors, in particular members of the BMP family, serve to regulate synapse assembly and morphogenesis. Role: PI

Minnesota Medical Foundation/Viking Children’s Fund 09/01/2003 – 08/31/2004 “Mapping of a 10q deletion associated with ASD” The goal of this project was to begin molecular characterization of a Twin Cities kindred identified in two University of Minnesota clinics with a familial history of autism and learning disability. The behavioral abnormalities in this kindred are associated with a small deletion on chromosome 10. Our goal was to identify the deletion in this kindred and then assess whether genetic abnormalities in this region of chromosome 10 are associated with other autism kindreds gathered from throughout the United States. Role: PI

5R01-NS26862-13 (Arthur Lander, PI, Selleck, co-PI, subcontact) 04/01/1998 – 03/31/2003 NIH/NINDS “Role of Proteoglycans in Brain Development” This project was a sub-contract with the University of California, Irvine. The P.I. was Arthur Lander. The major goals of this project focused on uncovering the functions of glypicans-1 and –2 in the mammalian nervous system, and on relating glypican function to specific structural features. Role: PI of Sub-Contract

RG0304/1999-M08/01/1999 – 01/31/2003 Human Frontiers Science Program “Genetic and Biochemical Analysis of Glycosaminoglycan Function in Development” The major goal of this grant was to combine genetic and biochemical studies of Drosophila and C. elegans to examine the function of heparan sulfate during tissue assembly and morphogenesis. This was a multi-investigator grant, for which I was the coordinator of the three projects. It was Curriculum Vitae: Scott B. Selleck p. 11 the product of an international meeting organized by Dr. Arthur Lander and myself, sponsored by Human Frontiers, to bring proteoglycan biochemists and developmental geneticists together to forge collaborations that would provide an in-depth understanding of these molecules in vivo.

RO1 GM067208 Nakato (co-PI) Selleck (co-PI) 08/01/2005 – 07/31/2009. “Molecular Mechanisms of Morphogen Gradient Formation”. Proteoglycans are important regulators of morphogens, both at the level of signaling at the cell surface, and controlling their stability and concentration in the extracellular matrix. This grant explored the balance of these two elements for critical developmental patterning molecules.

RO1 HL081715 Hall (PI) (Selleck, co-investigator) 04/01/2007 - 03/31/2012 “The Role of Heparan Sulfate in Vascular Remodeling “. Proteoglycans control the signaling of molecules critical for vascular remodeling that occurs upon recovery from injury. This work explored the importance of proteoglycans in this process.

Department of Defense Idea Award. Selleck (PI) Neufeld Co-PI. 3/2007 – 02/2010 $400,000 total. “Understanding the function of Tuberous Sclerosis Complex genes in neural development: roles in synapse assembly and axon guidance". My laboratory became interested in the molecular basis of behavioral disorders in children, using Drosophila as a model for understanding these disorders. We discovered that a number of key neurodevelopmental processes are affected by genes known to affect human behavioral development.

Viking Children’s Fund Selleck (PI) 11/01/2005 – 10/31/2007 $50,000 total. “Molecular and Genetic Analysis of Autism Spectrum Disorder Susceptibility Genes”.

Cure Autism Now Grant Selleck (PI) 02/01/1007 – 01/31/2008 $120,000 total “Genomic instability of an interval on chromosome 10q and its contribution to autism spectrum disorder”. This grant provided funds for our investigations of a genomic disorder associated with instability at chromosome 10q. We published two papers on this disorder, which is now part of any standard screen for autism or developmental delay.

T32 HD007480 O’Connor (PI), Selleck (co-PI) 05/01/2007 - 04/30/2012 NIH $174,611“Developmental Biology Training Program”, Predoctoral training program. A training program grant for PhD students at the University of Minnesota. This was a competitive renewal we were able to obtain while I was Director of the Developmental Biology Center.

Current Support Cure Sanfilippo Foundation. Selleck (PI). 7/2018-6/2019. $100,000 total funds. “The Role of Autophagy in Mucopolysaccharidoses and Its potential as a Therapeutic Target”.

Pending Grant Applications

RO1 NIH R01 GM127445-01. Selleck (PI). 1,250,000 5 years. “Heparan sulfate metabolism and the regulation of autophagy”