Curriculum vitae Scott B. Selleck Contact Information Department of Biochemistry & Molecular Biology, The Pennsylvania State University 206D Life Science Bldg, University Park, PA 16802 Tel: 814-863-4655 (office); cell: 612-868-4444 Email: [email protected]; [email protected] (personal) Education B.A. (Zoology), summa cum laude, 1979. University of Washington, Seattle, WA. M.D./Ph.D. (Molecular Biology) 1981-89. Washington University School of Medicine. Postdoctoral Training Dept. of Brain and Cognitive Sciences, M.I.T., 1989-90. Laboratory of Dr. Hermann Steller. Dept. of Biology, Brandeis University, 1990-1993. Laboratory of Dr. Kalpana White. Professional Experience Assistant Professor, Dept. of Molecular & Cellular Biology and Division of Neurobiology, University of Arizona, 3/93-8/99. Associate Professor with tenure, Dept. of Molecular & Cellular Biology, University of Arizona, 8-99-2002. Director, Master’s Program in Applied Biosciences (2000-01), U. of Arizona (wrote and was awarded grant from the Sloan Foundation). Director, Program in Molecular Genetics, Arizona Cancer Center, University of Arizona, 7/00- 9/02. Professor, Director and Harrison Land Grant Endowed Chair, The Developmental Biology Center, The University of Minnesota, Depts. of Pediatrics and Genetics, Cell Biology, & Development, 9/02-9/09. Director, The University of Minnesota Autism Initiative, 2007-2009. Professor and Head, Department of Biochemistry & Molecular Biology, The Pennsylvania State University (8/09-7/2017) Current Position: Professor of Biochemistry & Molecular Biology, Eberly College of Science with joint appointment in the Penn State College of Medicine Honors and Awards Phi Beta Kappa, University of Washington, 1979. Medical Scientist Training Program (M.D./Ph.D.) NIH Fellowship, Washington University School of Medicine, 1981-1988. Spencer T. and Ann W. Olin Medical Scientist Fellow, Washington University School of Medicine, 1989. Life Sciences Research Foundation Postdoctoral Fellowship, 1989-1992. Burroughs Wellcome Travel Grant Award for U.S.-Great Britain Exchange, 1990. NIH Postdoctoral Training Grant, 1992-93. Alfred P. Sloane Foundation Research Fellowship for Young Investigators, 1994-96. Basil O'Connor Young Investigator Award, March of Dimes, 1995-97. Martin Lenz Harrison Land Grant Chair in Pediatrics, University of Minnesota, 2002-2009. Curriculum Vitae: Scott B. Selleck p. 2 Publications Papers in refereed journals Selleck, S.B. and Simpson, J.B. (1980). Intracranial injection parameters which affect angiotensin-II induced drinking. Pharmacol. Biochem. Behav. 13: 581-584. Fantel, A.G., Greenaway, J.C., Shepard, T.H., Juchau, M.R., and Selleck, S.B. (1981). The teratogenicity of cytochalasin D and its inhibition by drug metabolism. Teratology 23:223-231. Selleck, S.B., Elgin, S.C.R., and Cartwright, I.L. (1984). Supercoil-dependent features of DNA structure at Drosophila locus 67B1. J. Mol. Biol. 178:17-33. Selleck, S.B., and Majors, J. (1987). Photofootprinting in vivo detects transcription dependent changes in yeast TATA boxes. Nature 325:173-177. Selleck, S.B., and Majors, J. (1987). In vivo DNA binding properties of a yeast transcription- activator protein. Mol. Cell. Biol. 7:3260-3267. Selleck, S.B., and Majors, J. (1988). In vivo photofootprint changes at sequences between the yeast GAL1 UASG and TATA require activated GAL 4 protein but not a functional TATA element. Proc Nat Acad Sci USA 85:5399-5403. Selleck, S.B. and Steller, H. (1991). The influence of retinal innervation on neurogenesis in the first optic ganglion of Drosophila. Neuron 6:83-99. Selleck, S.B., Gonzalez, C., Glover, D., and White, K. (1992). Regulation of the G1-S transition in post-embryonic neuronal precursors by axon ingrowth. Nature 355:253-255. Nakato, H., Futch, T., and Selleck, S.B. (1995). The division abnormally delayed (dally) gene: a putative integral membrane proteoglycan required for cell division patterning during post- embryonic development of the nervous system in Drosophila. Development 121:3687-3702. Manseau,. L., Baradaran, A., Brower, D., Budhu, A., Elefant, F., Glover, D., Kaiser, K., Palter, K., Phan, H., Philp, A., Yang, M., and Selleck, S. (1997). GAL4 enhancer traps expressed in the embryo, larval brain, imaginal discs, and ovary of Drosophila. Developmental Dynamics 209: 310- 322. Penton, A., Selleck, S.B., and Hoffmann, F.M. (1997). Regulation of cell cycle synchronization by decapentaplegic during Drosophila eye development. Science 275:203-206. Jackson, S.M., Nakato, H., Sugiura, M., Jannuzi, A., Oakes, R., Kaluza, V., Golden, C., and Selleck, S.B. (1997). division abnormally delayed, a Drosophila glypican, controls cellular responses to the TGF-ß-related morphogen, Dpp. Development 124: 4113-4120. Tsuda, M., Kamimura, K., Nakato, H., Archer, M., Staatz, W., Fox, B., Humphrey, M., Olson, S. Siegfried, E., Stam, L., and Selleck, S.B. (1999). A cell surface proteoglycan, Dally, regulates Wingless signaling in Drosophila. Nature 400:276-280. Toyoda, H., Kinoshita-Toyoda, A., and Selleck, S.B. (2000). Structural analysis of glycosaminoglycans in Drosophila melanogaster and C. elegans and demonstration that tout-velu, a Drosophila gene related to EXT tumor suppressors, affects heparan sulfate in vivo. J. Biol. Chem. 275: 2269-2275. Curriculum Vitae: Scott B. Selleck p. 3 Toyoda, H., Kinoshita-Toyoda, A., Fox, B., and Selleck, S. B. (2000). Structural Analysis of Glycosaminoglycans in Animals Bearing Mutations in sugarless, sulfateless, and tout-velu. Drosophila homologues of vertebrate genes encoding glycosaminoglycan biosynthetic enzymes. J Biol Chem 275: 21856-21861. Bulik, D. A., Wei, G., Toyoda, H., Kinoshita-Toyoda, A., Waldrip, W. R., Esko, J. D., Robbins, P. W., and Selleck, S. B. (2000). sqv-3, -7, and -8, a set of genes affecting morphogenesis in C. elegans encode enzymes required for glycosaminoglycan biosynthesis. Proc Nat Acad Sci (USA)97:10838-43. Fujise, M., Izumi, S., Selleck, S.B., and Nakato, H. (2001). dally, a Drosophila integral membrane proteoglycan selectively participates in Wingless or Dpp signaling in the specification of adult sensory bristles. Dev Biol. 235(2):433-48. Nakato, H., Fox, B., and Selleck, S.B. (2002). dally, a Drosophila member of the glypican family of integral membrane proteoglycans, affects cell cycle progression and morphogenesis via a Cyclin A-mediated process. J. Cell Sci. 115: 123-130. Rawson, J., Lee, M., and Selleck, S.B. (2003). Drosophila neuromuscular synapse assembly and function require the TGF-β type I receptor Saxophone and the transcription factor Mad. J Neurobio 55(2):134-150. Bornemann, D.J., Duncan, J.E., Staatz, W., Selleck, S.B. and Warrior, R. (2004). Abrogation of heparan sulfate synthesis in Drosophila disrupts Wingless, Hedgehog and Decapentaplegic signaling pathways. Development 131(9):1927-38. Kirkpatrick, C . Dimitroff, B,. Rawson, J. and Selleck, S.B. (2004) Dally-like, a Drosophila glypican, controls the distribution and signaling of the Wingless morphogen. Dev. Cell. 7(4): 513-523. Ledin, J., Staatz, W., Gotte, M., Selleck, S.B., Kjellen, L., and Spillmann, D. (2004). Heparan sulfate structure in mice with genetically modified heparan sulfate production. J Biol Chem 279(41):42732-42741. Lee, J-S., von der Hardt, S., Rusch, M.*, Stringer, S.*, Stickney, H., Talbot, W, Geisler, R., Nusslein- Volhardt, C., ., Selleck, S.B., Chien, C-B., and Roehl, H. Axon sorting in the optic tract requires HSPG synthesis by EXT2/dackel and EXTL3/boxer. Neuron. 44(6):947-60.*Selleck lab contributors Rawson, J. M., Johnson, K. B., Ge, X., Van Vactor, D., and Selleck, S. B. (2005). The Heparan Sulfate Proteoglycans Dally-like and Syndecan Have Distinct but Overlapping Functions in Axon Guidance and Visual System Assembly in Drosophila. Curr Biol 15(9):833-838. Chen, E., Stringer, S.E, Rusch2, M.A., Selleck, S.B.* and Ekker, S.E.* (2005). A Unique Role for 6-O Sulfation Modification in Zebrafish Vascular Development. Dev Biol 284(2):364-76. *joint corresponding authors. Pan, C., Nelson, M.S., Reyes, M., Koodie, L., Brazil, J.L., Stephenson, E.J., Zhao, R.C., Peters, C., Selleck, S.B., Stringer, S.E., Gupta, P. (2005). Functional abnormalities in heparan sulfate mucopolysaccharidosis-1 are associated with defective biological activity of FGF-2 on human multipotent progenitor cells. Blood 106(6):1956-64. Kirkpatrick C.A., Knox S.M., Staatz W.D., Fox B., Lercher D.M., Selleck, S.B. (2006). The function of a Drosophila glypican does not depend entirely on heparan sulfate modification. Dev Biol. Curriculum Vitae: Scott B. Selleck p. 4 300: 570-582 Balciuniene*, J. Feng*, N-P., Iyadurai, K. , Hirsch, B., Charnas, L., Bill, B., Staaf, J., Oseth L., Roberts, W., Avramopoulos, D., Borg Å, Valle, D., Schimmenti, L., Selleck,, S.B. (2007). Recurrent 10q22- 23 deletions: a genomic disorder on 10q associated with Cognitive and Behavioral Abnormalities AJHG 80(5):938-47. * contributed equally Knox,S. M.* , Ge,H.*, Dimitroff, B.D., Mitschele, K., Arsham, A. M., Neufeld,T. P., & O’Connor, M., Selleck, S. B. (2007) Mechanisms of TSC-mediated Control of Synapse Assembly and Axon Guidance PLoS ONE Apr 18;2:e375. * contributed equally. Dasgupta, U., Dixit, B.L., Rusch, M., Selleck, S.B., The, I. (2007). Functional conservation of the human EXT1 tumor suppressor gene and its Drosophila homolog tout velu. Dev. Genes & Evo. 217(8):555-61. Sun, M., Thomas, M.J., Herder, R., Selleck, S.B., and O’Connor, M.B. (2007). Presynapatic contributions of Chordin to hippocampal plasticity and spatial learning. J. Neuroscience 27(29):7740-50. Clement, A., Wiweger, M., von der Hardt, S., Rusch, M.A., Selleck, S.B., Chien, C.B., Roehl, H.H. (2008). Regulation of skeletal morphogenesis by sulphated proteoglycans in Danio rerio, PLoS Genetics Jul 25;4(7):e1000136. Adhikari,N., Rusch, M., Mariash, A., Li, Q., Selleck, S.B. and Hall, J.L. (2008) Alterations in Heparan sulfate in the Vessel in response to Vascular Injury in the Mouse. J. Cardiovascular Trans Res :1, (3), pp. 236-240. Ren, Y., Kirkpatrick, C.A., Rawson, J. Sun, M., and Selleck, S.B.