Scientific Programme Tuesday, 22 September 2020 08:00

Scientific Programme

Tuesday, 22 September 2020

Oral Session, Oral Session, Stream 1 08:00 - 09:00 Oral Session 1 - Sleep disordered breathing and cardiovascular disease

Chairs M. Bonsignore (Palermo, IT) H. Hrubos-Strøm (NO)

08:00 - 08:10 O01 Subclinical myocardial injury in co-morbid insomnia and sleep apnoea (COMISA): data from the Akershus Sleep Apnoea study F.D. Sigurdardottir (Oslo, NO)

08:10 - 08:20 O02 FACE: phenotyping analysis of chronic heart failure (CHF) patients with sleep disordered breathing (SDB) indicated for adaptive servoventilation (ASV): 2-year follow-up results R. Tamisier (Grenoble, FR)

08:20 - 08:30 O03 Long-term mortality of patients after acute myocardial infarction with reduced (< 45%) left ventricular ejection fraction and moderate to severe sleep apnea O. Ludka (Brno, CZ)

08:30 - 08:40 O04 Impact of sleep apnea on the overall cardioembolic risk in patients with atrial fibrillation: a cross-sectional analysis of the ESADA cohort M.F. Pengo (Milano, IT)

08:40 - 08:50 O05 Nocturnal pulse rate variability analysis in patients with positional obstructive sleep apnoea D. Álvarez (Valladolid, Valladolid, ES)

08:50 - 09:00 O06 Effect of continuous positive airway pressure on the burden of arrhythmia in patients with paroxysmal atrial fibrillation and sleep apnea: a randomized controlled trial G.M. Traaen (Oslo, NO)

Oral Session, Oral Session, Stream 2 08:00 - 09:00 Oral Session 2 – Insomnia

Chairs K. Spiegelhalder (Freiburg, DE) D. Riemann (Freiburg, DE)

08:00 - 08:10 O07 The effect of internet-guided cognitive, behavioral and chronobiological interventions on depressive symptoms and brain function in depression- prone insomnia subtypes J. Leerssen (Amsterdam, NL)

08:10 - 08:20 O08 Arousals during sleep are associated with cortical amyloid-β burden and cognition in healthy older adults D. Chylinski (Liège, BE)

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Tuesday, 22 September 2020

08:20 - 08:30 O09 Consistent altered internal capsule white matter microstructure in insomnia disorder T. Bresser (Amsterdam, NL)

08:30 - 08:40 O10 Dreaming and insomnia: Link between physiological parameters of rapid eye movement sleep and mentation characteristics F. Benz (Freiburg, DE)

08:40 - 08:50 O11 Effectiveness of a guided online cognitive behavioral treatment (i-Sleep) for primary care patients with insomnia A. van Straten (Amsterdam, NL)

08:50 - 09:00 O12 Cognitive behavioural therapy for insomnia among shift workers: analyses of an RCT study up to 24 months post-treatment H. Järnefelt (Helsinki, FI)

Oral Session, Oral Session, Stream 3 08:00 - 09:00 Oral Session 3 - Networks & Connectivity

Chairs V. Vyazovskiy (Oxford, UK) A. Luthi (Lausanne, CH)

08:00 - 08:10 O13 Synaptome maps of the brain change with circadian cycle and sleep deprivation in mice D. Koukaroudi (Edinburgh, UK)

08:10 - 08:20 O14 Association between sleep regulation and neuroimaging-derived myelin markers M. Deantoni (Liège, BE)

08:20 - 08:30 O15 Association of REM sleep with brainstem myelin content among healthy young and older individuals P. Talwar (Liege, BE)

08:30 - 08:40 O16 Role of sleep in brain cortical synaptic remodelling following synthetic torpor in the rat T. Hitrec (Bologna, IT)

08:40 - 08:50 O17 Disruption of hypocretin/orexin receptor 1 or 2 in dopaminergic neurons differentially regulates waking theta and fast-gamma oscillations S. Li (Lausanne, Switzerland (CHE), CH)

08:50 - 09:00 O18 Large-scale brain network connectivity during post-learning sleep forecasts motor memory consolidation: a high-density electroencephalography study S. Titone (Leuven, BE)

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Tuesday, 22 September 2020

General, Virtual Exhibition 08:00 - 18:30 Virtual Exhibition - open to visit

Poster Session, Poster, E-poster library 08:30 - 19:00 E-Poster Library

click here to reach the ePoster library

Poster Session, Poster, Poster Networking Lounge 08:30 - 09:30 Poster Networking Lounge - open to visit

P01 Key components of the pulse wave amplitude signal during sleep are associated with prevalent hypertension in two large community samples F. Decup (Adelaide, SA, AU)

P02 Development of predictive model for obstructive sleep apnea using machine learning H.W. Kim (Yangsan, KR)

P03 Associations between NREM and REM sleep EEG spectral power, amyloid burden, grey matter volume and perfusion in ageing G. Rauchs (Caen, FR)

P05 The role of hyaluronic acid and hyaluronidase-1 in obstructive sleep apnoea M. Meszaros (Budapest, HU)

P06 Selective orexin 2 receptor agonist TAK-925 to treat narcolepsy: results of a randomized, double-blind, placebo-controlled, multiple-ascending- dose, phase 1 study in patients with narcolepsy type 1 S.-I. Tanaka (Osaka, JP)

P07 Infant sleep during COVID-19 in the USA: longitudinal analysis of auto- videosomnography data M. Kahn (Adelaide, SA, AU)

P08 Association between insomnia and subjective cognitive functioning: a population-based study I. Hwang (Seoul, KR)

P09 The impact of home confinement due to COVID-19 pandemic on sleep quality and insomnia symptoms among the Italian population F. Salfi (L'Aquila, IT)

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Tuesday, 22 September 2020

P10 A 3.5-year follow-up of combined CBT-I and chronotherapy shows stronger long-term effects on mood than on insomnia severity O. Lakbila-Kamal (Amsterdam, NL)

P11 Behavioural and physiological investigations into sleep in sharks M. Kelly (Melbourne, VIC, AU)

P12 Sex-induced, male-specific sleep loss in Antechinus E. Zaid (Melbourne, VIC, AU)

P13 Splitting sleep between the night and a daytime nap is beneficial for declarative memory, regardless of total sleep opportunity S.A. Jamaluddin (Singapore, SG)

P14 Reduced sleep time is associated with increases in frontal sleep-like activity and emotion regulation failures G. Avvenuti (Lucca, IT)

P15 Age-related differences in sleep-dependent prospective memory consolidation R. Leong (Singapore, SG)

P16 Whole-brain profiling of neuronal and microglial activities behind inflammation-mediated sleep phenotype K. Kon (Tokyo, JP)

P17 Effects of sleep deprivation on birdsong performance in adult Australian magpies J. Gaviraghi Mussoi (Auckland, Auckland, NZ)

P18 Validation of a wearable heart rate and sleep tracker compared with polysomnography in police and rescue workers under natural conditions B. Stucky (Zurich, CH)

P19 Chemogenetic activation of VGLUT2 neurons in the left nodose ganglion of the vagal nerve suppresses rapid-eye-movement sleep in mouse N. Cherrad (Lausanne, CH)

P20 A comparative test of the brain warming hypothesis for REM sleep G. Ungurean (Seewiesen, DE)

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Tuesday, 22 September 2020

SES Meeting, Stream 4 09:00 - 13:00 SES Meeting

We are pleased to announce the joint virtual congress of the European Sleep Research Society (ESRS) and the Spanish Sleep Society (SES). Both meetings will be coordinated in parallel and attendants will be able to attend both meetings with only one registration. Programme/Programa: https://ses.org.es/eventos/xviii-reunion-anual- ses-2020/ Nos complace anunciaros la celebración conjunta del 25 Congreso de la Sociedad Europea de Investigación en Sueño (ESRS) y la XXVIII Reunión Anual de la Sociedad Española de Sueño. Ambos congresos virtuales se coordinarán simultáneamente, y se podrá acudir a ambos congresos con una única inscripción.

Teaching Course, Teaching Course, Stream 1 09:15 - 12:15 Teaching Course 1 - Year in review (basic)

The three speakers will review the recent publications devoted to sleep mechanisms and functions both in humans and animals. They will in particular review latest breakthroughs in circadian regulation, role of sleep in learning and memory, neuronal network responsible for the sleep-waking cycle, translational studies on the mechanisms at the origin of RBD, narcolepsy, insomnia and sleep apnea.

Chairs T. DeBoer (Leiden, NL) P.-H. Luppi (Lyon, FR)

09:15 - 10:45 Circadian system T. DeBoer (Leiden, NL)

10:45 - 12:15 Sleep mechanisms and functions P.-H. Luppi (Lyon, FR)

Teaching Course, Teaching Course, Stream 2 09:15 - 12:15 Teaching Course 2 - Year in review (clinical)

Chairs L. Nobili (Milan, IT)

09:15 - 09:55 Sleep disorders in autoimmune neurological diseases J. Santamaria (Barcelona, ES)

09:55 - 10:35 Narcolepsy across the lifespan: clinical features and treatments G. Plazzi (Bologna, IT)

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Tuesday, 22 September 2020

10:35 - 11:15 Disorders of arousal: pathophysiological mechanisms and differential diagnosis L. Nobili (Milan, IT)

11:15 - 11:55 Phenotypic Subtypes of Obstructive Sleep Apnea: implications for treatment. W. Randerath (Solingen, DE)

11:55 - 12:15 Discussion

Teaching Course, Teaching Course, Stream 3 09:15 - 12:15 Teaching Course 3 - Emerging technologies in evaluating sleep and sleep disorder breathing

Chairs E.S. Arnardottir (Reykjavik, IS)

09:15 - 10:00 Can we move beyond the AHI? E.S. Arnardottir (Reykjavik, IS)

10:00 - 10:45 Oxygen desaturation and CO2 patterns – visual interpretation and algorithms W. Randerath (Solingen, DE)

10:45 - 11:30 Machine learning in sleep apnea T. Leppänen (Kuopio, FI)

11:30 - 12:15 Contactless recording of OSA and PLMs T. Penzel (Berlin, DE)

Poster Session, Poster, Poster Networking Lounge 09:30 - 10:30 Poster Networking Lounge - open to visit

P21 Treating sleep disorders following traumatic brain injury in adults: time for renewed effort? K. Stewart (Edinburgh, UK)

P22 Nocturnal heart rate variability indices are associated with incident cardiovascular events in a prospective population-based cohort M. Berger (Lausanne, CH)

P23 Efficacy of Pitolisant 20mg in reducing excessive daytime sleepiness for patients with obstructive sleep apnea syndrome: an individual patient data meta analysis C. Caussé (Paris, FR)

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Tuesday, 22 September 2020

P24 Hot Topic: residual daytime sleepiness (RES) after obstructive sleep apnea (OSA) treatment in the European Sleep Apnea Database (ESADA) study: prevalence and predictors C. Barbera (Palermo, IT)

P25 Depressive symptoms and daytime sleepiness are stronger predictors of subjective cognitive decline than objective cognitive performance, APOE genotype and subjective sleep quality in elderly individuals A. Michalak (Norwich, Norfolk, UK)

P26 Excessive daytime sleepiness in Siberian adolescents with Internet addiction S. Tereshchenko (Krasnoyarsk, Красноярский кр&, RU)

P27 Disturbances of continuous sleep and circadian rhythms account for behavioural difficulties in children with Autism Spectrum Disorder E. Yavuz-Kodat (Strasbourg, FR)

P28 Insomnia severity and mental health in the Italian adult population during home confinement due to Covid-19 Pandemic V. Bacaro (Rome, IT)

P29 Higher polygenic risk for insomnia is associated with lower delta power during habitual sleep in young individuals without sleep disorders E. Koshmanova (Liege, BE)

P30 Insomnia subtypes and efficacy of Cognitive-Behavioral Therapy L. Ferini-Strambi (Milan, IT)

P31 Self-control performance, but not subjective vigilance level, decreases after brief periods of task practice and increases following caffeine intake G. Avvenuti (Lucca, IT)

P32 Allocentric vs egocentric memory in rats and humans: effects of sleep A. Samanta (Nijmegen, Gelderland, NL)

P33 Association between daytime rest, night-time sleep and hippocampal integrity in healthy older adults M. Baillet (Liège, BE)

P34 Heritability of sleep traits: a systematic review and meta-analysis D. Kocevska (Amsterdam, ---, NL)

P35 Clinical and polysomnographic comparison between excessive dreamers and healthy controls C. Krämer (Lausanne, CH)

P36 Impact of menstrual cycle phase, progesterone and oral contraceptives on sleep and overnight memory consolidation C.P. Plamberger (Salzburg, AT)

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Tuesday, 22 September 2020

P37 'Real life' coffee intake in genetically caffeine sensitive individuals attenuates neurobehavioural impairments caused by chronic sleep restriction D.M. Baur (Zürich, CH)

P38 Pre- and postsynaptic effects of hypocretin (orexin) on excitatory transmission in layer V pyramidal neurons of murine premotor cortex G. Colombo (Milano, Milano, IT)

P39 It's about time: resting during daytime alters attention in the aged M. Reyt (Liège, BE)

P40 Testing the performance of an electrocardiogram-based sleep staging algorithm using reflective photoplethysmography data in a sleep disordered population B.M. Wulterkens (Eindhoven, NL)

Poster Session, Poster, Poster Networking Lounge 10:30 - 11:30 Poster Networking Lounge - open to visit

P41 Prevalence of sleep disturbance and determinants of sleepiness in a cohort of Italian hospital physicians: the PRESOMO Study R.M. Lecca (Cagliari, IT)

P42 Uptake of digital cognitive behavioural therapy for insomnia - changes in response to COVID-19 A. Gardiner (Newcastle, UK)

P43 Prevalence of sleep disorders in the adult population of Armenia: an epidemiological study S. Khachatryan (Yerevan, AM)

P44 Sleep and physical activity before and during incremental covid-19 mobility restrictions J.L. Ong (Singapore, SG)

P45 Oximetry-derived predictors of atrial fibrillation in patients with obstructive sleep apnea M. Blanchard (Angers, FR)

P47 The effectiveness of cognitive behaviour therapy for insomnia on repetitive negative thinking: a meta-analysis A. Ballesio (Rome, IT)

P48 Chronotype and insomnia subtypes' symptoms in adults M. Miller Mendes (Coimbra, PT)

P50 Depressive and anxiety symptoms in idiopathic REM sleep behaviour disorder E. Rocío Martín (Madrid, Madrid, ES)

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Tuesday, 22 September 2020

P51 Nights and days during the COVID-19 pandemic: a two weeks study on day-to-day associations between subjective sleep quality and mental complaints P. Simor (Budapest, HU)

P54 Quantitative aspects of the Sympatho Vagal Balance reported from 523 polysomnographic recordings D. Cugy (Bordeaux, FR)

P55 Impact of the EEG montage on the diagnosis of OSAS when using enhanced polygraphy (PG+) P. Escourrou (Clamart, FR)

P56 Deep learning enables sleep staging from photoplethysmogram in a clinical population with obstructive sleep apnea suspicion H. Korkalainen (Kuopio, FI)

P57 Validation of an automatic arousals detection method for whole-night sleep EEG recordings D. Chylinski (Liège, BE)

P58 Individual nocturnal cardiac autonomic activity and sleep patterns in elite female soccer players during an international tournament J. Costa (Porto, PT)

P59 Variability of visual and automated sleep stage scoring in elderly D. Chylinski (Liège, BE)

P60 Are there sleep related differences in the neurotransmitters Glutamate and GABA between typical developing children and children with ADHD? C. Volk (Zurich, CH)

Poster Session, Poster, Poster Networking Lounge 11:30 - 12:30 Poster Networking Lounge - open to visit

P61 Sleep and insomnia-related complaints before and during imposed confinement in the COVID-19 pandemic: results from a global survey O. Mairesse (Brussels, BE)

P62 Comorbidities in patients with coexisting obstructive sleep apnea and heart failure with different ejection fractions C.L. Ardelean (Timisoara, Timis, RO)

P64 Impact of napping and sleep-education on daytime functioning in older adults A. Lesoinne (Liège, BE)

P65 Identifying anatomical factors of obstructive sleep apnea by ultrasound fan-scan imaging of pharyngeal airway A. Chen (Taipei, TW)

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Tuesday, 22 September 2020

P66 Obstructive sleep apnea and evolution of Alzheimer's disease patients G. Piñol-Ripoll (LLieda, ES)

P67 Prevalence of nocturnal tachyarrhythmias and long-term functional outcome in patients with obstructive sleep apnea syndrome and acute ischemic stroke D.G. Martínez Roque (Monterrey, Nuevo León, MX)

P68 Changes in an electroencephalographic marker of synaptic renormalization during sleep after ischemic stroke V. Jaramillo (Zurich, CH)

P69 Slow-wave sleep and cognitive impairment in Parkinson disease S.J. Schreiner (Zurich, CH)

P70 Modified melatonin profile, shorter sleeping time and poorer sleep quality in children with obesity M. Gombert (Valencia, Valencia, ES)

P71 Effects of sleep loss and attention on negotiations T. Sundelin (Stockholm, SE)

P72 Personality and work related cognitions associated with healthy sleep in employees with regular working schedules S. Carvalho Bos (Coimbra, PT)

P73 Prior knowledge: a prerequisite to sleep-dependent declarative memory consolidation processes in children? A. Peiffer (Brussels, BE)

P74 What do we remember from sleep? Influence of sleep stage and sleep inertia on information encoding T. Reess (Stockholm, SE)

P75 Complete sleep and local field potential analysis regarding estrus cycle, pregnancy, postpartum and post-weaning periods and homeostatic sleep regulation in female rats A. Tóth (Budapest, HU)

P76 Reindeer (Rangifer tarandus) sleep can be measured by non-invasive electroencephalography M. Furrer (Zurich, CH)

P77 A sleep behaviour intervention to improve cardiometabolic health in individuals with overweight and obesity: a randomized controlled trial R.H.P. Henst (Cape Town, Western Cape, ZA)

P78 Mapping changes in delta band power following auditory stimulation targeting slow wave up- and down-phases: a source-localization study E. Krugliakova (Zürich, CH)

P79 Role of sleep in the dephosphorylation of brain Tau protein following synthetic torpor in the rat T. Hitrec (Bologna, IT)

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Tuesday, 22 September 2020

P80 Conditional deletion of miRNA in hypocretin neurons: a new mouse model of narcolepsy M.-L. Possovre (Lausanne, Vaud, CH)

Poster Session, Poster, Poster Networking Lounge 12:30 - 13:30 Poster Networking Lounge - open to visit

P81 Chronic intermittent hypoxia relates to low levels of circulating soluble low-density lipoprotein receptor-related protein 1 M. Meszaros (Budapest, HU)

P82 Predictors of impaired cerebral perfusion and cerebral desaturation in patients with obstructive sleep apnea syndrome Z. Zhang (Barmelweid, CH)

P83 Effect of CPAP treatment on cardiovascular outcomes in adults with acute coronary syndrome and nonsleepy obstructive sleep apnoea: a secondary analysis of the RICCADSA trial Y. Peker (Istanbul, TR)

P84 Retrospective analysis of inconclusive cardiorespiratory sleep studies with worsening classification of obstructive sleep apnea / hypopnea syndrome on polysomnography S. Costa-Martins (Covilhã, Castelo Branco, PT)

P85 Maternal sleep apnea and fetal heart rate monitoring I. Madaeva (Irkutsk, RU)

P86 Changes in sleep pattern in mothers and their children during COVID-19 lockdown in Italy N. Cellini (Padova, PD, IT)

P87 The relation between sleep spindle power and emotion regulation across development K. Bothe (Salzburg, Salzburg, AT)

P88 Insomnia and behavioural and cognitive functioning in children with attention deficit hyperactivity disorder - a case-control study X. Li (Hong Kong, Hong Kong, HK)

P89 Could polysomnography identify potential SIDS/BRUE victims? Subtle changes in arousability during sleep in healthy infants (SIDS: Sudden infant death syndrome, BRUE: Brief Resolved Unexplained Event) M. Merino Andreu (Madrid, ES)

P90 Time of day X chronotype effects on adolescent's emotional states C. Bettencourt (Coimbra, PT)

P91 Distinguishing sleep from wake with a radar sensor: a contact-free real- time sleep monitor for hospital rooms H.S.A. Heglum (Trondheim, NO)

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Tuesday, 22 September 2020

P92 The composition of physical activity, sedentary behaviour and sleep duration across 24-hours: associations with self-rated sleep quality in middle-aged and elderly persons A.I. Luik (Rotterdam, NL)

P93 Impact of COVID-19-related lockdown on self-reported sleep characteristics in the Italian population N. Cellini (Padova, PD, IT)

P95 Different but complementary roles of NREM and REM sleep in facilitation of visual perceptual learning associated with neurotransmitters changes revealed by magnetic resonance spectroscopy M. Tamaki (Providence, RI, US)

P96 Hypocretinergic interactions with the serotonergic system regulate REMS and cataplexy A. Seifinejad (Lausanne, VD, CH)

P97 Altitude-induced sleep apnea is highly dependent on the ethnic (Sherpa vs Tamang) background G. Heiniger (Lausanne, CH)

P98 Changes of microglial morphology within a circadian period S. Steffens (Helsinki, Uusimaa, FI)

P99 Influence of CRHR1 genotype on sleep and cortisol of healthy volunteers after Trier Social Stress Test in the late evening A. Steiger (Munich, DE)

P100 Plasma amiloid β42 and obstructive sleep: pilot study I. Madaeva (Irkutsk, RU)

Teaching Course, Teaching Course, Stream 1 13:00 - 16:00 Teaching Course 4 - Sleep and omics

Chairs S. Archer (Guildford, UK) P. Franken (Lausanne, CH) S. Brown (Zurich, CH)

13:00 - 13:34 Why sleep omics? D.-J. Dijk (Surrey, UK)

13:34 - 14:08 Approaches to omics data analysis and interpretation E. Laing (Guildford, UK)

14:08 - 14:42 Sleep genomics and the sleep-wake-driven transcriptome S. Archer (Guildford, UK)

14:42 - 15:16 Multi-omic systems genetics approaches to sleep regulation P. Franken (Lausanne, CH)

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Tuesday, 22 September 2020

15:16 - 15:50 Sleep-wake cycles and synaptic omics S. Brown (Zurich, CH)

15:50 - 16:00 Discussion

Teaching Course, Teaching Course, Stream 2 13:00 - 16:00 Teaching Course 5 - CBT-I

Chairs D. Riemann (Freiburg, DE)

13:00 - 14:00 Etiology and pathophysiology of insomnia C. Baglioni (Freiburg, DE)

14:00 - 15:00 Sleep hygiene, relaxation and cognitive techniques E. Hertenstein (Berne, CH)

15:00 - 16:00 Stimulus control and sleep restriction A. Johann (Freiburg, DE)

Teaching Course, Early Career Day, Stream 3 13:00 - 16:00 Early Career Researcher Network Day (ECRN) - Becoming a leader in science

Chairs K. Porcheret (Oslo, NO) A.I. Luik (Rotterdam, NL)

13:00 - 13:05 Welcome and introduction K. Porcheret (Oslo, NO)

13:05 - 15:00 Learning to be a leader A.-M. Turcotte (Lausanne, CH)

15:00 - 15:20 New committee member elections

15:20 - 16:00 What it’s like to have a neuroscience (and sleep) research group T. Bekinschtein (Cambridge, UK)

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Tuesday, 22 September 2020

SES Meeting, Stream 4 13:00 - 14:00 SES Industry Symposia - Narcolepsia y confinamiento. Cómo afecta el COVID-19 al paciente narcoléptico

Chairs J.J. Poza (ES)

13:00 - 13:03 Welcome + Introduction J.J. Poza (ES)

13:03 - 13:29 Narcolepsia y confinamiento. Cómo afecta el COVID-19 al paciente narcoléptico J.J. Poza (ES)

13:29 - 13:55 Casos Clínicos M. Merino (ES)

13:55 - 14:00 Live Q&A

Poster Session, Poster, Poster Networking Lounge 13:30 - 14:30 Poster Networking Lounge - open to visit

P101 IL-33 and soluble ST2 receptor as mediators of systemic inflammation in OSA patients A. Gabryelska (Lodz, PL)

P102 Cluster analysis to identify clinically significant obstructive sleep apnea phenotypes M.G. Silveira (Sant Boi de Llobregat, Barcelona, ES)

P103 Nocturnal arterial pulsation waveforms of obstructive sleep apnea patients are associated with increased number of lapses in psychomotor vigilance task S. Kainulainen (Kuopio, FI)

P104 Transsphenoidal adenomectomy is associated with the amelioration of obstructive sleep apnea in patients with active acromegaly I. Filchenko (St Petersburg, RU)

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Tuesday, 22 September 2020

P105 CPAP adherence trajectories in obstructive sleep apnea - unsupervised clustering using real-life datasets S. Bailly (Grenoble, FR)

P106 Time of day and chronotype effects on children's intellectual capacity L. Pires (Coimbra, PT)

P107 Do specific types of sleep disturbances represent risk factors for poorer health related quality of life in inflammatory bowel disease? A longitudinal cohort study A. Scott (Sheffield, UK)

P108 Sleep duration on the first night following a traumatic event and subsequent intrusive memories K. Porcheret (Oslo, NO)

P109 Sleep characteristics in patients with tramadol dependence A. Saleh (Cairo, EG)

P110 Dissociative symptoms in narcolepsy L. Quaedackers (Heeze, NL)

P111 Infant habitual sleep and its relation to sustained and orienting attention in the first year of life: a longitudinal eye-tracking and actigraphy study L.K. Gossé (London, UK)

P112 Sleep of gifted children: a polysomnographic study M. Thieux (Lyon, FR)

P113 Processing of musical rhythms is partially preserved in REM but not NREM sleep R. Sifuentes-Ortega (Brussels, BE)

P114 A novel, time-controlled, caffeine-release formula attenuates behavioural, cognitive, emotional, and physiological signs of sleep inertia D. Dornbierer (Zurich, CH)

P115 Effect of COVID-19 lockdown on sleep in young children: preliminary results from an international online survey A. Markovic (Fribourg, CH)

P116 Self-reported reasons for reduced alertness among commercial airline pilots M. Sallinen (Helsinki, Uusimaa, FI)

P117 Impact of social jetlag and chronotype among non-standard fixed schedules S. Gamboa Madeira (Lisbon, PT)

P118 A new set of composite, non-redundant electroencephalogram measures of non-rapid eye movement sleep based on the power law scaling of the Fourier spectrum R. Bódizs (Budapest, HU)

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Tuesday, 22 September 2020

P119 Investigating top-down processing from wakefulness to sleep: behavioural results of a novel auditory paradigm in wakefulness P. Topalidis (Salzburg, AT)

P120 Predicting slow wave sleep through a topographic template of slow oscillations K.D. Fehér (Bern, CH)

SES Meeting, Stream 4 14:00 - 15:00 SES Meeting

Poster Session, Poster, Poster Networking Lounge 14:30 - 15:30 Poster Networking Lounge - open to visit

P121 Gender analysis of the clusters of sleep apnoea phenotypes from the ESADA database A. Pataka (Thessaloniki, GR)

P122 Mandibular advancement devices effects on temporomandibular disorder signs and symptoms: a systematic review and meta-analysis A. Alessandri-Bonetti (Rome, IT)

P123 The interacting effects of age and HIV status on chronotype in a rural South African population K. O'Brien (Guildford, UK)

P124 Post-learning resting-state functional connectivity and sleep spindles activity contribute to procedural memory consolidation in young and older adults A. Mary (Brussels, BE)

P125 Renalase and hypertension - demographic and clinical correlates in obstructive sleep apnea H. Martynowicz (Wroclaw, PL)

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Tuesday, 22 September 2020

P126 Adjusted CBT-i for sleep problems in bipolar disorder - results from a pilot study S. Jernelöv (Stockholm, SE)

P127 Sleep disturbances and mental disorders in help-seeking unaccompanied refugee minors A.A. Schlarb (Bielefeld, DE)

P128 One case of a non-24 hour sleep-wake disorder treated by total sleep deprivation followed by combination of chronobiotic treatments K. Guichard (Bordeaux, FR)

P129 Circadian and homeostatic processes in delayed sleep-wake phase disorder patients C. Reis (Lisboa, PT)

P130 Narcolepsy treatments: comparison of pitolisant, modafinil and sodium oxybate via a network meta-analysis C. Caussé (Paris, FR)

P131 Technology usage predicts increased health risks, mediated by weekday and weekend sleep in adolescents C. Holden (Nottingham, UK)

P132 Sleep does not facilitate human fear memory consolidation Y.G. Pavlov (Tuebingen, DE)

P133 Effect of sleep on schema-mediated motor memory consolidation S. Reverberi (Leuven, BE)

P134 Relationship between slow wave activity during post-motor learning sleep and hippocampal responses is modulated by stress N. Dolfen (Leuven, BE)

P135 Exposure to smartphone LED-screens in the evening and their impact on sleep-dependent memory consolidation C. Hoehn (Salzburg, AT)

P136 Polysomnography for everybody - validation of an open-hardware board for low-cost sleep classification D.P.J. Heib (Salzburg, Salzburg, AT)

P137 Chemotherapy reduces running wheel activity and alters the strength of the output of the circadian clock Y. Wang (Leiden, NL)

P138 EEG changes during the transition from slow-wave sleep to wakefulness are associated with melatonin and cortisol level K. Liaukovich (Moscow, RU)

P139 The impact of sleep length on neural processing of pleasant musical stimuli R. Vasko (Kraków, PL)

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Tuesday, 22 September 2020

P140 An EEG study on sleep homeostasis in a songbird species, the European starling (Sturnus vulgaris): REM sleep, why bother? S.J. van Hasselt (Groningen, NL)

SES Meeting, Stream 4 15:00 - 16:00 SES Industry Symposia - Cómo tratar pacientes complejos de sueño: Pacientes con apneas centrales

Chairs I. Cano (Madrid, ES)

15:00 - 15:30 Title to be announced V. Cabriada (Baracaldo, Vizcaya, ES)

15:30 - 16:00 Title to be announced J. Puertas (Alzira, Valencia, ES)

Poster Session, Poster, Poster Networking Lounge 15:30 - 16:30 Poster Networking Lounge - open to visit

P141 Withings sleep apnea detector, a non-intrusive, unattended device, can be a substitute to polygraphy to diagnose sleep apnea syndrome P. Edouard (Issy-les-Moulineaux, FR)

P142 Obstructive sleep apnea in people with intellectual disabilities: compliance with and effect of continuous positive airway pressure N. van den Broek (Heeze, NL)

P143 Chronic insomnia in patients with moderate or severe obstructive sleep apnea after maxillomandibular advancement R. Wix Ramos (Madrid, Madrid, ES)

P144 A positive treatment effect of cervical collar in moderate obstructive sleep apnea - a pilot study F. Delijaj (Uppsala, SE)

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Tuesday, 22 September 2020

P145 Diagnosis of sleep apnea without sensors on the patient's face A. Sabil (Paris, FR)

P146 JZP-258 dose titration and transition from sodium oxybate in a placebo- controlled, double-blind, randomised withdrawal study in adult participants with narcolepsy with cataplexy Y. Dauvilliers (Montpellier, FR)

P147 Narcolepsy type 1 features through the lifetime: age impact on clinical and polysomnographic phenotype A. Lividini (Bologna, IT)

P148 Response to pitolisant therapy in patients with difficult to treat hypersomnia J.S. Kaler (London, UK)

P149 New 2013 incidence peak in childhood narcolepsy: more than vaccination? Z. Zhang (Barmelweid, CH)

P150 Is it more about mood than about sleep? An investigation into moderators and mediators of treatment response to cognitive behavioural therapy for insomnia C. Sandlund (Stockholm, SE)

P151 Slow oscillation-spindle coupling strength relates to overnight gross- motor learning M.A. Hahn (Salzburg, AT)

P152 Sleep preferentially promotes learning of egocentric and intrinsic spatial reference systems in a visuospatial task

P153 System of brain rhythms during sleep M. Wislowska (Salzburg, AT)

P154 Slow wave sleep has no homeostatic effect on fear extinction learning E. Friesen (Saarbruecken, DE)

P155 Associations between gut microbiota and sleep quality in older adults with insomnia: distinctions between short and normal sleep duration I. Haimov (Alon Hagalil, IL)

P156 Cold habituation and modification in sleep and electroencephalogram in rats O. Shylo (Kharkiv, UA)

P157 Slow-wave potentiation is age-dependent and characterizes early-night sleep in teenagers and young adults K. van Welzen (Barcelona, ES)

P158 Shift work-related circadian disruption on diurnal rest-activity and sleep patterns in morning- and evening-type first responders under naturalistic conditions I. Clark* (Zurich, Zurich, CH)

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Tuesday, 22 September 2020

P159 Sleep in chronic pain conditions - the 0.02 hz-fluctuation reveals the hidden microarousals R. Cardis (Lausanne, CH)

P160 Neurophysiology of NREM parasomnias G. Mayer (Marburg, DE)

General, Opening/Closing Session, Stream 1 16:15 - 17:15 Live Opening / Welcome Session and Young Scientists Symposium

Chairs W. McNicholas (Dublin, IE) A. Iranzo (ES) T. Saaresranta (Turku, FI)

16:15 - 16:20 Welcome note W. McNicholas (Dublin, IE)

16:20 - 16:25 Welcome note A. Iranzo (ES)

16:25 - 16:28 Presentation of the European Sleep Science Award T. Paunio (Helsinki, Finland, FI)

16:28 - 16:30 Thank you note T. Stenberg (FI)

16:30 - 16:40 O19 Cortical regulation of global sleep homeostasis L.B. Krone (Oxford, UK)

16:40 - 16:50 O20 Human sleep slow waves are associated with traveling hemodynamic waves at cortical level M. Betta (Lucca, Lucca, IT)

16:50 - 17:00 O21 Association of anxiety scores at baseline with long-term adherence to CPAP in adults with coronary artery disease and obstructive sleep apnoea in the RICCADSA trial Y. Celik (Istanbul, TR)

17:00 - 17:10 O22 Are children genetically predisposed to poor sleep? A polygenic risk score study in the general pediatric population D. Kocevska (Amsterdam, ---, NL)

Poster Session, Poster, Poster Networking Lounge 16:30 - 17:30 Poster Networking Lounge - open to visit

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Tuesday, 22 September 2020

P161 Effects of solriamfetol on 24-hour blood pressure patterns in participants with excessive daytime sleepiness associated with obstructive sleep apnoea P.J. Strollo, Jr. (Pittsburgh, PA, US)

P162 Effects of weight loss during long-term solriamfetol treatment on cardiometabolic indices S. Bujanover (Palo Alto, CA, US)

P163 Can algorithms that analyze machine data predict adherence to CPAP therapy? Data from the Pays de la Loire Sleep Cohort A. Sabil (Paris, FR)

P164 Assessing the burden of excessive daytime sleepiness associated with obstructive sleep apnoea: a time trade-off study in the UK general public K. Tolley (Buxton, Derbyshire, UK)

P165 CPAP-treatment may improve sensory function in the soft palate of obstructive sleep apnea patients H. Rashed (Linköping, SE)

P167 Daridorexant, a novel dual orexin receptor antagonist, delivers significant improvement in sleep parameters and daytime function for patients with insomnia disorder T. Roth (Detroit, MI, US)

P168 Subtypes of cognitive-behavioural therapy for insomnia efficacy in a long- term follow-up L. Ferini-Strambi (Milan, IT)

P169 Insomnia affects brain reactivity to humorous films E. Altena (Bordeaux Cedex, FR)

P170 Effects of solriamfetol on 24-hour blood pressure patterns in participants with excessive daytime sleepiness associated with narcolepsy P.J. Strollo, Jr (Pittsburgh, PA, US)

P171 Maturational and developmental trajectories of slow and fast frequency activity in the transition from childhood to adolescence: the Penn State Child Cohort A. Ricci (Hershey, PA, US)

P172 Maturational and developmental trajectories of sigma-frequency activity in the transition from childhood to adolescence: the Penn State Child Cohort A. Ricci (Hershey, PA, US)

P173 Sleep-related strengthening of functional connectivity in caudal and motor cortical areas support problem solving N.H. van den Berg (Ottawa, ON, CA)

P174 Age-related changes in sleep impact learning-related functional connectivity in the cortico-striatal-hippocampal system Z. Fang (Ottawa, ON, CA)

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Tuesday, 22 September 2020

P175 Rhynchophylline, an inhibitor of the EphA4 receptor, causes modifications in sleep architecture in mice M.N. Ballester Roig (Montreal, QC, CA)

P176 Effects of sleep timing and regularity on endogenous phase of melatonin C.J. Hilditch (Moffet Field, CA, US)

P177 Non-REM sleep network connectivity represents an altered, not a reduced state of consciousness S. Fogel (Ottawa, ON, CA)

P178 Greater cortical thickness in the occipital cortex is associated with larger slow wave amplitude and stronger cortical involvement in centro-frontal brain areas G. Avvenuti (Lucca, IT)

P179 Within-night comparison of auditory stimulation modalities on efficacy to enhance slow wave activity across cortical regions S. Huwiler (Zürich, Zürich, CH)

P180 Validation against PSG of an Ambulatory Circadian Monitoring (ACM) procedure for the estimation of sleep in children B. Rodriguez-Morilla (Murcia, ES)

Respiratory, Round Table, Stream 1 17:30 - 18:00 Round Table 1 - Implementation of the EU directives on sleep apnea and insomnia

The European Union Directive (2014/85/EU) had to be adopted by 1 January 2016. The rules on driving health of patients with sleep disordered breathing as well as on narcolepsy and patients using sedative medications were included. How has the Directive been implemented in different EU countries? In this symposium we will review the current Directives and methods of evaluation ability to stay awake and driving fitness. What are the best methods to predict driving risk of patients with sleep disorders in Group 1 drivers and in professional Group 2 drivers? Maintenance of Wakefulness Test (MWT), OSLER test, driving stimulators and real road driving tests will be discussed. What about use of ESS? How do they correlate with driving fitness? We will address the risks of sleep apnea and/or insomnia and alcohol/ hypnotics and sleep deprivation. The symposium is of interest to all clinicians in sleep medicine who are evaluating driving fitness of patients with different sleep disorders.

Chairs M. Partinen (Helsinki, FI)

17:30 - 17:37 Rationale of the EU Directive on sleep apnea - what needs to be done? W. McNicholas (Dublin, IE)

17:37 - 17:44 Insomnia and use of hypnotics related to driving fitness S. Garbarino (Genoa, IT)

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Tuesday, 22 September 2020

17:44 - 17:51 Clinical and paraclinical markers of fitness to drive: implementation into health care P. Philip (Bordeaux Cedex, FR)

17:51 - 17:58 Measuring sleepiness in professional drivers: implementation into tranportation companies? M. Partinen (Helsinki, FI)

Psychiatry, Round Table, Stream 2 17:30 - 18:00 Round table 2 - Sleep, insomnia and depression: how are these linked?

About 70% of patients with a clinical depression also suffer from insomnia and about 40% from all people with insomnia suffer from a depression. In order to prevent or treat patients adequately we like to know the mechanisms through which sleep impacts cognitive and emotional functioning and how this in turn leads to an enhanced risk for a clinical depression. This will be considered in this symposium including both basic- and clinical research perspectives. We start with the maturation of the brain. The focus is on the association betweenEEG slow waves during NREM sleep and the learning related plastic changes, as well as on the consequences of this on the cognitive processes and depression. Next neuroimaging findings on self-conscious emotions in insomnia will be presented. It will be shown that overnight adaptation of amygdala reactivity to novel shameful experiences fails in proportion to the fragmentation of REM sleep, and that the limbic circuit continues to activate with recall of distressing experiences of decades ago in people with insomnia. The third speaker will focus on the relationship between sleep, insomnia and emotion regulation combining ecological and laboratory data. Psychophysiological measures of sleep, emotional reactivity and emotion regulation are evaluated in patients with insomnia, sleep deprived good sleepers, and good sleepers control in an ecological momentary assessment design and in laboratory settings. Finally, the last speaker will discuss treatment implications. She will argue that it is better to treat insomnia than depression when both conditions occur at the same time.

Chairs A. van Straten (Amsterdam, NL)

17:30 - 17:40 Sleep and brain maturation: cognitive and emotional consequences R. Huber (Zurich, CH)

17:40 - 17:50 Self-conscious emotions in insomnia R. Wassing (Sydney, AU)

17:50 - 18:00 O24 Treating patients with insomnia and depression J. Lancee (Amsterdam, NL)

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Tuesday, 22 September 2020

Oral Session, Oral Session, Stream 3 17:30 - 18:45 Oral Session 4 - Sleep Deprivation

Chairs H.-P. Landolt (Zurich, CH) C. Reichert (Basel, CH)

17:30 - 17:40 O25 Caffeine effectively counteracts performance impairments during the first two days of chronic sleep restriction in genetically caffeine-sensitive individuals E.-M. Elmenhorst (Cologne, DE)

17:40 - 17:50 O26 Impact of chronic sleep restriction on A₁ adenosine receptor availability D. Lange (Cologne, DE)

17:50 - 18:00 O27 The impact of sleep deprivation on cortical functional integration and cognitive performances N. Cross (Montreal, QC, CA)

18:00 - 18:10 O28 Closed-loop acoustic neurostimulation during sleep: induction of slow oscillations to increase sleep stability in the presence of environmental noise L. Talamini (Amsterdam, NL)

18:10 - 18:20 O29 Behavioral and neural correlates of emotional facial expressions stimuli processing in adults with ADHD before and after sleep deprivation: an ERP study O. Dan (Emek Yeezreel, IL)

18:20 - 18:30 O30 Neurobehavioural functions during variable and stable short sleep schedules T. Koa (Singapore, SG)

18:30 - 18:40 O31 The effect of sleep deprivation on task performance, mind wandering and sleepiness in young and older adults J. Schwarz (Stockholm, SE)

Poster Session, Poster, Poster Networking Lounge 17:30 - 18:30 Poster Networking Lounge - open to visit

P181 Factors involved in success with myofunctional therapy to treat sleep disordered breathing based on a telemedicine mHealth application C. O´Connor -Reina (Marbella, Malaga, ES)

P182 Comparison of night to night variation of the home sleep polygraphic examination R. Rozgonyi (Pécs, HU)

P183 Sex-related differences in young obstructive sleep apnea (OSA) patients: cross-sectional data from the European Sleep Apnea Database (ESADA) M. Bonsignore (Palermo, IT)

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Tuesday, 22 September 2020

P184 Clinical judgement in mild OSA patients from the European Sleep Apnoea Database (ESADA) study S. Schiza (Heraklion, GR)

P185 Maintenance of wakefulness test: how does it predict accident risk in patients with sleep disorders? P. Philip (Bordeaux Cedex, FR)

P186 Ambulatory EEG-measured sleep associated with attention- deficit/hyperactivity disorder symptom severity among adolescents J. Lunsford-Avery (Durham, NC, US)

P187 A re-examination of the antidepressant effects of sleep deprivation in major depressive disorder under highly controlled conditions J. Goldschmied (Philadelphia, PA, US)

P188 Increased fronto-parietal theta asymmetry during REM sleep may be associated to insomnia: an EEG study T. Provencher (Quebec, QC, CA)

P189 Effects of cognitive behavioral therapy for insomnia on objective and subjective sleep quality during benzodiazepine withdrawal among older adults with chronic insomnia N. Cross (Montreal, QC, CA)

P190 Sleep spindles as a potential interictal biomarker of the epileptogenic zone in drug-resistant focal epilepsy V. Latreille (Montreal, QC, CA)

P191 Impact of the COVID-19 epidemic on dream features in the Italian population

P192 Critical concerns in the interpretation of STOP and STOP-BANG in the elderly L. Lusic Kalcina (Split, HR)

P195 Napping restores hippocampal-dependent task performance in habitual nappers R. Leong (Singapore, SG)

P196 Relationships between locus coeruleus structural integrity and subjective sleep quality across the lifespan: a 7T MRI study M. Van Egroo (Maastricht, NL)

P197 Sleep in barnacle geese is strongly affected by season and moon phase S.J. van Hasselt (Groningen, NL)

P198 Rapid iris movements during REM sleep in pigeons: a new window into the sleeping brain G. Ungurean (Seewiesen, DE)

P199 RNA-Seq analysis of galaninergic neurons from ventrolateral preoptic nuleus identifies expression changes between sleep and wake X. Guo (Philadelphia, PA, US)

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Tuesday, 22 September 2020

P200 Toward a complete taxonomy of resting state networks across wakefulness and sleep Z. Fang (Ottawa, ON, CA)

Neurology, Round Table, Stream 1 18:15 - 18:45 Round table 3 - Sleep and neurology: new guidelines

1) Sleep and Stroke. This GL was produced by 16 experts (chairs: C. Bassetti, W. Randerath) from the ESRS, the EAN (European Academy of Neurology), the ERS (European Sleep Research Society) and the ESO (European Stroke Organization). The aim of this GL was the analysis of the bidirectional link between sleep disorders and stroke. A total of 13 research (PICO) questions were evaluated in a systematic literature search using a step-wise hierarchical approach. A publication is currently in press simultaneously in the European Journal of Neurology and European Respiratory Journal. 2) Narcolepsy. This GL was produced by 18 experts (chairs: C. Bassetti, U. Kallweit) from the ESRS, the EAN, and the EU-NN (European Narcolepsy Network). Pharmacological and non-pharmacological treatments of narcolepsy were assessed. A total of 10 research (PICO) questions were evaluated in a systematic literature search using a step-wise hierarchical approach. A publication is scheduled for Spring 2020. 3) Sleep and Epilepsy. This GL was produced by 17 experts (chair: L. Nobili) from the ESRS, the EAN, and the ILAE (International League Against Epilepsy). In this GL standard procedures for the diagnostic pathway of patients with possible sleep- related epilepsies (SRE) and the general management of patients with SRE and comorbidity with sleep disorders were defined. A publication is scheduled for Spring 2020.

Chairs C. Bassetti (Berne, CH)

18:15 - 18:22 Sleep and stroke/narcolepsy C. Bassetti (Berne, CH)

18:22 - 18:29 Sleep and stroke W. Randerath (Solingen, DE)

18:29 - 18:36 Narcolepsy U. Kallweit (Witten, DE)

18:36 - 18:43 Sleep and epilepsy L. Nobili (Milan, IT)

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Tuesday, 22 September 2020

Animal Basic, Round Table, Stream 2 18:15 - 18:45 Round table 4 - What is REM sleep? Evolutionary and developmental perspectives

Sleep researchers have long sought to determine which species have REM sleep as a means of identifying clues to its origin and function. However, current approaches have relied on definitions of REM sleep derived from adults of relatively limited numbers of mammalian species. Extrapolating this adult, mammalian perspective across species has exposed limitations of defining “what is REM sleep?”, particularly when applied to non-mammalian or non-avian species. The reliance on a mammalian definition may also hinder a greater understanding of how sleep may be expressed across the animal kingdom. In this symposium, Paul-Antoine Libourel will discuss evidence of REM-like states in ectotherms such as molluscs, fish and reptiles, with particular emphasis on the Tegu and Bearded Dragon. His recent work has demonstrated the presence of two well-defined sleep states in reptiles while identifying similarities and differences with the mammalian expression of REM sleep. Niels Rattenborg will review the diversity of REM sleep expression in avian and mammalian species, highlighting how components of REM sleep may be present or absent across species, or how some components considered specific to REM sleep may occur instead in non-REM sleep in other species. Mark Blumberg will explore the how various components of REM sleep coalesce over time during development from birth and how peeling back the layers of REM sleep, as one travels back in time to birth, challenge our ability to define this sleep state. This developmental approach may reveal parallels to understanding REM-like states in non-avian and non-mammalian species. Finally, Markus Schmidt will present the energy allocation hypothesis, an evolutionary theory suggesting that REM sleep is a behavioral strategy to promote global shifts in whole-organism resource allocations to optimize survival and reproductive success. The types of functions coupled with REM sleep are predicted to vary across species in relation to specific selection pressures, such as how non- REM-REM sleep cycling in mammals and birds optimizes REM sleep timing such that it occurs when the need for costly thermoregulatory defense is minimized. Together, these presentations will review new, cutting-edge, research on REM sleep, from behavior to function, across the animal kingdom.

Chairs M. Schmidt (Berne, CH)

18:15 - 18:22 REM sleep and the coalescence of its components during development M. Blumberg (Iowa City, US)

18:22 - 18:29 The diversity of avian and mammalian REM sleep expression N. Rattenborg (München, DE)

18:29 - 18:36 From cuttlefish to reptiles: Do ectotherms really have REM sleep? P.A. Libourel (Lyon, FR)

18:36 - 18:43 REM sleep and the energy allocation hypothesis M. Schmidt (Berne, CH)

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Tuesday, 22 September 2020

Psychiatry, European Network Session, Stream 1 19:00 - 20:00 European Network Session: Insomnia

Chairs D. Riemann (Freiburg, DE) T. Blanken (Amsterdam, NL)

19:00 - 19:15 The European CBT-I academy: an update C. Baglioni (Freiburg, DE)

19:15 - 19:30 Stepped care for insomnia - a new project K. Spiegelhalder (Freiburg, DE)

19:30 - 19:45 O32 Predicting, preventing and alleviating depression: network analyses point to the primary importance of insomnia T. Blanken (Amsterdam, NL)

19:45 - 20:00 Insomnia research at Oxford University: an update S. Kyle (Oxford, UK)

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Wednesday, 23 September 2020

General, Virtual Exhibition 08:00 - 18:30 Virtual Exhibition - open to visit

Oral Session, Oral Session, Stream 1 08:30 - 09:45 Oral Session 5 – Neurology & Hypersomnia & Movement disorders & Parasomnias

Chairs L. Nobili (Milan, IT) M. Schmidt (Berne, CH)

08:30 - 08:40 O33 Video-polysomnographic assessment for the diagnosis of disorders of arousal in children R. Lopez (Montpellier, FR)

08:40 - 08:50 O34 A brain signature of prodromal Lewy body dementia in isolated REM sleep behavior disorder S. Rahayel (Montreal, QC, CA)

08:50 - 09:00 O35 Dopamine transporter neuroimaging and clinical predictors for phenoconversion of idiopathic REM sleep behavior disorder to overt synucleinopathy: an international multicenter study D. Arnaldi (Genoa, IT)

09:00 - 09:10 O36 Do sleep homeostasis influence bedtime to morning-on-waking mobility in Parkinson's disease? A quantitative EEG study T. Aumont (Montréal, QC, CA)

09:10 - 09:20 O37 Cataplexy-free days in a phase 3, placebo-controlled, double-blind, randomised withdrawal study of JZP-258 in adults with narcolepsy with cataplexy Y. Dauvilliers (Montpellier, FR)

09:20 - 09:30 O38 Effect of treatment on cognitive and attention problems in children with narcolepsy type 1 K. Janssens (Zwolle, NL)

09:30 - 09:40 O39 Decrease in sleep depth is associated with higher cerebrospinal fluid neurofilament light levels in Alzheimer's disease patients G. Piñol-Ripoll (LLieda, ES)

Oral Session, Oral Session, Stream 2 08:30 - 09:45 Oral Session 6 - Psychiatry and Psychotherapy

Chairs T. Paunio (Helsinki, Finland, FI) E. Hertenstein (Berne, CH)

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Wednesday, 23 September 2020

08:30 - 08:40 O40 Racing thoughts in healthy young adults are influenced by sleep deprivation but not by blue enriched white light exposure R. Glacet (Strasbourg, FR)

08:40 - 08:50 O41 Treatment with imagery rehearsal therapy and/or mianserin in trauma- affected refugees: results from a randomized controlled trial H. Sandahl (Ballerup, Danmark, DK)

08:50 - 09:00 O42 Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD working group J. Leerssen (Amsterdam, NL)

09:00 - 09:10 O43 Objectively estimated sleep characteristics are associated with grief over time: the Rotterdam study M. de Feijter (Rotterdam, Noord-Holland, NL)

09:10 - 09:20 O44 Antenatal insomnia and increased postnatal dehydroepiandrosteron predict postnatal depression T. Mikoteit (Solothurn, CH)

09:20 - 09:30 O45 Become your own SLEEPexpert: design, implementation and first evaluation of a pragmatic behavioral treatment program for insomnia in patients with acute psychiatric disorders C.L. Schneider (Berne, CH)

09:30 - 09:40 O46 The temporal dynamics of sleep disturbance and psychopathology in psychosis: a digital phenotyping study N. Meyer (London, UK, UK)

Oral Session, Oral Session, Stream 3 08:30 - 09:45 Oral Session 7 - Sleep oscillations

Chairs R. Huber (Zurich, CH) V. Vyazovskiy (Oxford, UK)

08:30 - 08:40 O47 In vitro generation of sleep spindles and slow waves using thalamo- cortical co-cultures M. Bandarabadi (Lausanne, Vaud, CH)

08:40 - 08:50 O48 Role of the Locus Coeruleus in the continuity-fragility dynamics of NREM sleep A. Osorio-Forero (Lausanne, Vaud, CH)

08:50 - 09:00 O49 Sharp wave-ripples in human amygdala and their coordination with hippocampus during NREM sleep R. Cox (Bonn, DE)

09:00 - 09:10 O50 Sleep slow waves generation and medial prefrontal microstructure in healthy older individuals M. Van Egroo (Maastricht, NL)

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Wednesday, 23 September 2020

09:10 - 09:20 O51 Coordination of brain and heart oscillations during NREM sleep C. Mikutta (Bern, Bern, CH)

09:20 - 09:30 O52 Interoception in REM sleep: cortical responses to heartbeats differ across phasic and tonic REM periods P. Simor (Budapest, HU)

09:30 - 09:40 O53 Impact of the PER3 VNTR polymorphism on delta power across different sleep contexts V. Muto (Liège, BE)

Poster Session, Poster, E-poster library 08:30 - 19:00 E-Poster Library

Poster Session, Poster, Poster Networking Lounge 08:30 - 09:30 Poster Networking Lounge - open to visit

P201 Development and validation of a sleep apnea syndrome screening algorithm using heart rate variability and long short-term memory A. Iwasaki (Kyoto, JP)

P202 Sleep disturbance as a mediator between problematic internet use and college adjustment Y. Lee (Seoul, KR)

P203 Sleep solutions for infants based on sleep-wake rhythms using a smartphone application A. Tange (Kanonji, Kagawa, JP)

P204 Quantitative evaluation of the function of the upper airway sensory fibres in patients with obstructive sleep apnoea Y. An (Guangzhou, CN)

P205 High altitude related sleep breathing disorders in health subjects Y. Duan (Beijing, CN)

P206 Selective orexin 2 receptor agonist TAK-925 to treat narcolepsy: results of a randomized, double-blind, placebo-controlled, multiple-ascending- dose, phase 1 study in patients with narcolepsy type 2 S.-I. Tanaka (Osaka, JP)

P207 Sleep and screen exposure across the beginning of life: deciphering the links using big-data analytics M. Gradisar (Adelaide, AU)

P208 Children with down syndrome and sleep disordered breathing display impairments in ventilatory control L.S. Siriwardhana (Melbourne, VIC, AU)

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Wednesday, 23 September 2020

P209 Multiple sleep latency test (MSLT) and 24 hour polysomnography (24hr PSG) for diagnosing pathological sleepiness in idiopathic hypersomnia M. Honda (Tokyo, JP)

P210 Light exposure rhythm and nocturnal urinary melatonin excretion in mild cognitive impairment patients J.H. Lee (Chunchon, KR)

P212 Auditory stimulation triggered by sleep spindle detection may enhance sleep-related memory consolidation J. Choi (Gwangju, KR)

P213 TAK-988, an orally available orexin 2 receptor-selective agonist, ameliorates narcolepsy-like symptoms in an orexin neuron-ablated mouse model of narcolepsy H. Kimura (Fujisawa, JP)

P214 A novel, orally available orexin 2 receptor-selective agonist with fast off- rate, TAK-994, induces wake-promoting effects in non-human primates H. Kimura (Fujisawa, JP)

P215 Multi-species comparison of restfulness in drosophila - keep your eye on the flies S. Omond (Melbourne, VIC, AU)

P216 Effects of age-related alteration in pupil size and ocular lens transmittance on differences between melatonin suppression in primary school children and that in middle-aged adults T. Eto (Fukuoka, JP)

P217 An automated detection of active muscle segments during sleep and its correlation with apnea hypopnea index Y. Duan (Beijing, CN)

P219 A causal role for sleep in maintaining high neurobehavioural performance in Australian magpies R.D. Johnsson (Melbourne, VIC, AU)

P220 A pilot study investigating the effect of wind farm versus road traffic noise on electroencephalogram (EEG) spectral power during sleep C. Dunbar (Bedford Park, SA, AU)

General, Webcast Library 08:30 - 19:00 Webcast Library - open to visit

Recorded sessions of previous day

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Wednesday, 23 September 2020

SES Meeting, Stream 4 09:00 - 11:00 SES Meeting

Poster Session, Poster, Poster Networking Lounge 09:30 - 10:30 Poster Networking Lounge - open to visit

P221 Changes in quality of sleep and quality of life during pregnancy H.E. Bae (Daegu, KR)

P223 Characterization of insomnia phenotype among obstructive sleep apnea patients O. Weiner (Lodz, PL)

P224 Predictors of sleep medication use among Norwegian nurses - a cross- sectional study I. Forthun (Bergen, NO)

P225 The school schedule effect on self-reported sleep length of children and youth in Spain D. Gabaldon-Estevan (Valencia, Valencia, ES)

P226 Insomnia and hypnotics in dementia patients J.H. Lee (Goyang-si, Gyeonggi-do, KR)

P227 Development of evening waking homeostatic pressure during early adolescence M. Gradisar (Adelaide, AU)

P228 Changes in objective sleep and anxiety during a longitudinal study of pre- adolescents C. Reynolds (Adelaide, SA, AU)

P230 The clinical significance of hepcidin as a predictive biomarker for treatment responses in restless legs syndrome H.-J. Im (Hwaseoung, KR)

P233 Mild sleep disturbances and sickness predict sensitivity to frustration L. Balter (Stockholm, SE)

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Wednesday, 23 September 2020

P234 Gender differences in Health Risk Behaviors and its correlates during COVID-19 pandemic T. Paiva (Lisboa, PT)

P235 Prevalence and determinants of bad sleep perception among Italian children and adolescents S. Malloggi (Florence, Florence, IT)

P236 Three-week observational study of intervals between shifts and fatigue among shift-working nurses: comparison of 12-hour and 16-hour shift schedules in a 2-shift system T. Kubo (Kawasaki, JP)

P238 An evaluation of wind farm noise effects on sleep using validated objective and subjective sleep assessment: a systematic review and meta- analysis T. Liebich (Adelaide, SA, AU)

P239 Suspected sleep disordered breathing and work-related sleep restriction in wildland firefighters: impact on physiological stress responses A. Wolkow (Notting Hill, VIC, AU)

Oral Session, Oral Session, Stream 1 10:00 - 11:00 Oral Session 8 - Paediatrics

Chairs O. Bruni (IT) K. Hoedlmoser (Salzburg, AT)

10:00 - 10:10 O54 Daytime continuous polysomnography in the diagnosis of pediatric narcolepsy type 1 F. Pizza (Bologna, IT)

10:10 - 10:20 O55 One year later: longitudinal effects of flexible school start times on teenage sleep, subjective benefits, and official grades A.M. Biller (Munich, DE)

10:20 - 10:30 O56 Comparison of surgical versus non-surgical therapies in the paediatric obstructive apnea-hypopnea syndrome P. Martínez Ruiz de Apodaca (Valencia, València, ES)

10:30 - 10:40 O57 Infant habitual sleep and its association with general development and socio-cultural environment in the first year of life L.K. Gossé (London, UK)

10:40 - 10:50 O58 Clinical spectrum in pediatric narcolepsy type 1: bad days, bad nights and late diagnosis É. Herráez Sánchez (Madrid, ES)

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Wednesday, 23 September 2020

10:50 - 11:00 O59 Does your baby have a sleep problem? Auto-videosomnography determinants of parent perceived infant sleep problems M. Kahn (Adelaide, SA, AU)

Neurology, Joint Symposium, Stream 2 10:00 - 11:00 Joint Symposium ESRS / EAN: Sleep, Circadian Rhythms and neurologic diseases

Chairs C. Bassetti (Berne, CH) R. Manni (Pavia, IT)

10:00 - 10:12 Circadian and longer cycles in epilepsy: pathophysiological and clinical implications M. Baud (Berne, CH)

10:12 - 10:24 Sleep and circadian disorders as risk factors of stroke E. Gottlieb (Heidelberg, AU)

10:24 - 10:36 Circadian rhythms and cluster headache R. Fronczek (Leiden, NL)

10:36 - 10:48 Circadian rhythms and dementia: identification tools and therapeutic approaches B. Guarnieri (Pescara, IT)

10:48 - 11:00 Sleep and circadian disturbances in Parkinson's disease P. Bargiotas (Nicosia, CY)

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Wednesday, 23 September 2020

Psychiatry, Symposium, Stream 3 10:00 - 11:00 The dynamics of REM sleep in emotion regulation and insomnia

Recent studies have demonstrated that a sound REM sleep contributes to maintaining individual’s emotional homeostasis by decreasing accumulation of emotional distress over time. In contrast, fragmented, poor sleep plays a role in persistent cognitive, emotional and physiological hyperarousal, a key characteristic of the pathophysiology of insomnia. The symposium provides a series of talks presenting new data on the links and causalities between emotional and physiological hyperarousal, insomnia, and REM sleep in clinical and non- clinical samples. First, Dr. Wassing (Australia) will present new perspectives on the neurobiology of self-conscious emotions, which are highly relevant in clinical psychiatry. The neuroimaging findings show that overnight amygdala adaptation to novel shameful events fails proportionally to the fragmentation of REM sleep, and distressing events of decades ago continue to activate the limbic circuits in people with insomnia. Second, drs. Blanken (The Netherlands) used latent class analysis to identify insomnia disorder (ID) subtypes, one of which with an exacerbated hyperarousal phenotype. This subtyping facilitates identification of patients with the highest risk of depression. Third, Dr. Feige (Germany) will present new whole-night event-related potential data probing auditory arousal in 50 ID patients and matched controls. Finally, Dr. Pesonen (Finland) will provide perspectives whether the resolution of self-conscious emotions can be moderated by targeted memory reactivation in REM vs NREM sleep in healthy individuals. The symposium is in the frontline in assimilating evidence from multiple studies to increase understanding of the role of REM sleep in the regulation of emotional distress both in adaptive and non-adaptive sleep patterns.

Chairs R. Wassing (Sydney, AU)

10:00 - 10:15 O60 Restless REM sleep in insomnia disorder and its detrimental effects on regulation of emotional distress R. Wassing (Sydney, AU)

10:15 - 10:30 O61 Insomnia disorder subtypes and the role of hyperarousal T. Blanken (Amsterdam, NL)

10:30 - 10:45 O62 Probing the perception of sleep - auditory event-related potentials in insomnia B. Feige (Freiburg, DE)

10:45 - 11:00 O63 Modulation of distress by targeted memory reactivation in REM and NREM sleep in healthy adolescents A.-K. Pesonen (Helsinki, FI)

Poster Session, Poster, Poster Networking Lounge 10:30 - 11:30 Poster Networking Lounge - open to visit

P241 Effects of novel coronavirus pandemic and self-isolation on sleep disorders M. Isayan (Yerevan, AM)

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P242 A comparative study of the nature and magnitude of problems sleeping in inflammatory bowel disease (IBD) compared to healthy controls A. Scott (Sheffield, UK)

P243 Obstructive sleep apnea risk assessment among hypertensive population in primary care J. Silva (Tavira, PT)

P244 Sleep characteristics in patients with interstitial lung disease K.J. Myall (London, UK)

P245 The prevalence of sleep-related car accidents in Armenia M. Isayan (Yerevan, AM)

P246 Circadian phase tailored light therapy in Alzheimer disease: preliminary findings on sleep and cognition R. Cremascoli (Porto Valtravaglia, IT)

P247 Ambient temperature (T_a) manipulation as a novel technique to dissociate REM sleep and cataplexy in narcolepsy B. Viberti (Bern, CH)

P248 The role of sleep problems in the cognitive behavioural model of compulsive checking behaviours M.L. Wong (Exeter, UK)

P249 Quality of life in a phase 3, placebo-controlled, double-blind, randomised withdrawal study of JZP-258 in adults with narcolepsy with cataplexy K. Šonka (Prague, CZ)

P250 Neuronal surface antibodies are common in children with narcolepsy and active movement disorders M.P. Giannoccaro (Bologna, IT)

P251 Interim cohort description of SOMNIA, a dataset containing clinical polysomnography combined with novel unobtrusive sleep monitoring techniques F.B. van Meulen (Eindhoven, NL)

P252 Validation and optimization of automatized sleep spindle detectors in elderly healthy subjects and patients with Parkinson's disease L. Rose (Lyngby, DK)

P253 20 years of hypocretin-1 measurements in cerebrospinal fluid using radioimmunoassay: technical and clinical lessons A. van der Hoeven (Leiden, South Holland, NL)

P254 Effects of night-time sleep quantity, quality and timing on the architecture of a daytime nap E.Y.Y. Lau (Hong Kong, HK)

P256 Does sleep deprivation cause stress in mice? A comparison of gentle handling versus novel object presentation sleep deprivation methods L. Lignos (London, UK)

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P257 Melatonin and thiobarbituric acid reactants in menopausal women with insomnia depending on the genotype of Clock 3111T/C gene polymorphism N. Semenova (Irkutsk, RU)

P258 Shifts in the circadian rhythm of children during COVID-19 pandemic in Poland and the impact of these alterations on their daily functioning M. Kaczor (Warsaw, None, PL)

P259 A novel method of detecting the ballistocardiograph from respiratory inductance plethysmography signals recorded during sleep G.H. Olafsdottir (Reykjavik, IS)

P260 Two main topographic patterns characterize morning-to-evening increases in low-frequency brain activity D. Grollero (Lucca, Lucca, IT)

SES Meeting, Stream 4 11:00 - 12:00 SES Industry Symposia - La personalización del tratamiento posicional. Debate y evidencia clínica en España y Portugal

Sponsored by Nox Medical

Chairs E.S. Arnardottir (Reykjavik, IS)

11:15 - 11:30 Beyond the AHI, new biomarkers of negative outcomes in OSA R. Heinzer (Lausanne, CH)

11:30 - 11:45 Apps, e- and m-Health in Sleep Medicine - a real alternative to the sleep lab? C. Schöbel (DE)

11:45 - 12:00 Nox BodySleep™ and Artificial Intelligence in Sleep Medicine J.S. Agustsson (Reykjavík, IS)

12:00 - 12:15 Live Q&A

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General, Case Discussion, Stream 3 11:15 - 12:15 Case Discussion - Complex behaviors during sleep: Challenging diagnostic cases

Chairs R. Manni (Pavia, IT)

11:15 - 11:35 Simple and Rising Arousal movements during sleep: dissecting Disorders of Arousal from Sleep Hypermotor Epilepsy G. Loddo (Bologna, IT)

11:35 - 11:55 RBD mimic: SDB arousal-related motor pattern M. Terzaghi (Pavia, IT)

11:55 - 12:15 Epilepsy-related violence during sleep R. Khatami (Barmelweid, CH)

Poster Session, Poster, Poster Networking Lounge 11:30 - 12:30 Poster Networking Lounge - open to visit

P261 Effectiveness of sodium oxybate in the prophylaxis of headache and sleep disturbances in patients with chronic and episodic cluster headache R. Khatami (Barmelweid, CH)

P262 Determinants of sleep quality in inflammatory bowel diseases M. Sochal (Lodz, PL)

P264 Age and gender related effects on the risk for osa and daytime sleepiness - a large population study S. Demirovic (Split, Splitsko-dalmatinska županija, HR)

P265 Heart rate variability during wakefulness as a marker of obstructive sleep apnea severity H. Qin (Berlin, DE)

P266 Is there a difference in polysomnographic parameters between shift and day workers with insomnia? A subgroup analysis J. Ell (Freiburg, DE)

P267 Music intervention for insomnia disorder: a randomized controlled trial K.V. Jespersen (Aarhus, DK)

P268 The effects of cognitive behavioural therapy for insomnia on cognitive functioning in youths J. Ling (Hong Kong, Hong Kong, HK)

P269 Long working hours are significantly associated with frequent insomnia symptoms in the UK Biobank N. Walter (Freiburg, DE)

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P270 Insomnia mediates the relationship of occupational stress with depression, anxiety and burnout among shift working nurses K. Gustavsson (Warsaw, PL)

P271 Trazodone changes REMS structure and transiently prevents short-term memory decline and hypothalamic neuroinflammation in a mouse model of dementia P. de Oliveira (Guildford, Surrey, UK)

P272 Interrelationships of organisational commitment, self-control and sleep among working adults A. Zavadska (Cologne, DE)

P273 Intrinsic organization of fMRI networks during sleep and its relevance to dreaming L. Perogamvros (Geneva, CH)

P274 How Somno-Art software fills the gap between actimetry and polysomnography in accurately and efficiently characterizing sleep L. Thiesse (CH)

P275 Towards a handy screening tool for REM sleep behaviour disorder: RDBAct algorithm from wrist actigraphy data P.-L. Ratti (Venice, IT)

P276 Evaluating a multi-sensor approach for assessing sleep using wearable and smartphone technology X.Y. Chua (Singapore, SG)

P277 Sleep-wake cycle disturbances are exaggerated by epileptiform activity in early period of traumatic brain injury in rats A. Volkova (Moscow, RU)

P278 The emission of 22 kHz vocalizations during REM sleep in the rat F. Squarcio (Bologna, IT)

P279 Does sleep restriction affect learning from positive or negative feedback? A. Gerhardsson (Stockholm, SE)

P280 Cognitive deficits under total sleep deprivation with and without coffee: differential contribution of sleep debt and time on task A. Rabat (Brétigny sur Orge, FR)

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Wednesday, 23 September 2020

SES Meeting, Stream 4 12:00 - 12:30 SES Meeting

Respiratory, Joint Symposium, Stream 1 12:30 - 13:30 Spanish/ESRS symposia

Chairs A. Iranzo (ES) W. McNicholas (Dublin, IE)

12:30 - 12:45 Epidemiological and pathophysiological link between sleep apnoea and cancer I. Almendros (Barcelona, ES)

12:45 - 13:00 The clinical importance of the association between sleep apnoea and cancer D. Gozal (US)

13:00 - 13:15 The diagnosis of REM sleep behaviour disorder. How and how not to make it B. Högl (Innsbruck, AT)

13:15 - 13:30 REM sleep behaviour disorder as an opportunity to prevent Parkinson disease A. Iranzo (ES)

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Wednesday, 23 September 2020

Neurology, Symposium, Stream 2 12:30 - 13:30 Understanding the mechanisms of dopaminergic non- response in restless legs syndrome: a search into alternative treatment approaches

Dopamine agonists have been considered to be effective and safe first-line treatments for RLS for over 20 years. However, recent guidelines demonstrate an increasing concern about the iatrogenic, progressive symptom worsening which is present in up to 60% of patients over the first years of treatment. Although dopaminergic agonists are effective in RLS over the short-/midterm, the paradox is that most research suggests an existing dopaminergic hyperfunction in this disorder. The emerging question becomes how to explain the therapeutic mechanism of action by which dopamine agonists exert both their immediate therapeutic effects as well as their longer-term deleterious effects. The symposium will review our current state of knowledge on the pathophysiology of RLS, and particularly, on dopaminergic non-response. In particular, recent findings in an animal model of augmentation support a change in dopamine receptor phenotype following long-term administration of dopamine agonists. We will also review the involvement of iron-, glutamatergic, and adenosinergic mechanisms in the pathophysiology of RLS, all of which might lead to promising new treatment alternatives. Finally, we will discuss recent basic and epidemiological knowledge on the mechanism of action of opioids in the treatment of RLS.

Chairs D. Garcia-Borreguero (Madrid, ES)

12:30 - 12:42 O64 Brief introduction: augmentation of RLS symptoms: the scope of the problem D. Garcia-Borreguero (Madrid, ES)

12:42 - 12:54 O65 Altered dopamine receptor phenotype in an animal model of augmentation S. Clemens (Greenville, US)

12:54 - 13:06 O66 The role of brain iron deficiency in therapeutic non-response C. Garcia Malo (Madrid, ES)

13:06 - 13:18 O67 Targeting glutamatergic and adenosinergic dysfunction D. Garcia-Borreguero (Madrid, ES)

13:18 - 13:30 O68 Opioid treatment of RLS: degree, doses, differences, mechanisms, receptors J.W. Winkelman (Boston, US)

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Wednesday, 23 September 2020

Human Basic, Symposium, Stream 3 12:30 - 13:30 Sleep oscillations: a new perspective on the development and decline of human cognition

The goal of this symposium is three-fold: First, we will discuss the functional relevance of developmental changes in large-scale oscillatory network communication for maturation of cognitive systems. Second, we will highlight novel methodological approaches to assess sleep oscillations across the lifespan and finally, explore how impaired sleep oscillation-synchrony contributes to age- and disease-related cognitive decline. Markus Werkle-Bergner will present lifespan comparisons in humans to promote mechanistic insights into how memory consolidation relies on the precisely timed interaction of sleep spindles and slow oscillations. He will highlight methodological challenges when investigating sleep oscillations across different developmental stages. Cristina Blanco-Duque will introduce a novel quality-based metric to quantify sleep spindles in adult male mice (C57BL6, GluA1-/-), and demonstrate how it gives a more systematic understanding of the complex spatiotemporal dynamics and function of spindles. Salome Kurth will compare high-density electroencephalogram of preschool-aged children with that of older ages and discuss whether slow oscillations and their large-scale connectivity actively mediate developmental modifications in the maturing brain. Randolph Helfrich will discuss how different temporal scales are critical for the development of the hippocampal-neocortical-dialogue in support of memory- formation using intracranial recordings in humans. He will demonstrate how insights from basic physiology can be leveraged to understand the pathophysiology of age- and disease-related cognitive decline. In sum our symposium shows a highly integrative nature, discusses novel results as well as methodological challenges, by describing studies across a range of species and methods, hence cover both basic human and animal sleep research as well as clinical populations.

Chairs K. Hoedlmoser (Salzburg, AT)

12:30 - 12:45 O69 A lifespan perspective on sleep and memory: potentials and challenges M. Werkle-Bergner (Berlin, DE)

12:45 - 13:00 O70 Spindle oscillatory-quality: a new metric for the spatiotemporal dynamics of sleep spindles C. Blanco-Duque (Oxford, UK)

13:00 - 13:15 O71 Slow oscillations in children and their potential as neurodevelopmental marker S. Kurth (Fribourg, CH)

13:15 - 13:30 O72 Network oscillations of the sleeping brain: the (patho-) physiology of human memory systems R. Helfrich (Tuebingen, DE)

Poster Session, Poster, Poster Networking Lounge 12:30 - 13:30 Poster Networking Lounge - open to visit

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P281 Compliance of postural sleep apnea patients with a new forehead vibratil device. Data not show L. Hidalgo Armas (Vitoria, ES)

P282 Ambulatory circadian monitoring in sleep disordered breathing A. Martinez-Nicolas (Murcia, Murcia, ES)

P284 Adding nocturia to STOP-Bang questionnaire - would it improve OSA diagnosis accuracy? J. Borges (Coimbra, PT)

P285 Changes in anxiety and depression levels in couples of patients with sleep apnea after one year of CPAP therapy I. Portela Ferreño (Vigo, Pontevedra, ES)

P286 Objective and subjective sleep quality in individuals experiencing recurrent isolated sleep paralysis K. Janků (Klecany, CZ)

P287 Is RSBD 'protective' against severe OSA? K. Lopes (Lisboa, PT)

P288 The multimodal complex nocturnal visual hallucinations V. Gnoni (London, UK)

P289 Mortality in patients with NREM parasomnias in the Danish population N. Suhak (Copenhagen, DK)

P290 Different effects of various blue enriched light regimes on wakefulness, wellbeing, and attention in sleepy and non-sleepy industrial shift workers A. Rodenbeck (Goettingen, DE)

P291 Inter- and intra-subject variability of N2 sleep spindles during daytime naps N. Cellini (Padova, PD, IT)

P292 Self-reported sleep duration, sleep quality and sleep problems in Mexicans adults: results of the Mexican National Halfway Health and Nutrition Survey 2016 A. Arrona-Palacios (Monterrey, Nuevo Leon, MX)

P293 The recovery of the processing of global irregularity during forced awakening from slow-wave sleep K. Liaukovich (Moscow, RU)

P294 Smartphone use at bedtime: the influence of sleep-smartphone hygiene, trait anxiety, and fear of missing out (FOMO) on sleep quality D. Hadar-Shoval (Emek Yezreel, IL)

P295 Adolescents' smartphone usages in the sleeping environment: parents' attitudes and involvement A. Dor (Emek Yezreel, IL)

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P296 The impact of one-night Total Sleep Deprivation on the effects of pavlovian cues on instrumental responses for food rewards W.S. Chan (Hong Kong, HK)

P297 Measures of sleep pressure in the wake EEG under standard versus soporific conditions following sleep deprivation S. Snipes (Zurich, CH)

P298 'Help me make it through the night' - an actigraphy study of sleep in early parenthood H. Oginska (Kraków, PL)

P299 Fractal regulation of human motor activity and its manifestation at circadian and ultradian time scales G. Hammad (Liège, BE)

P300 Confirmatory factor analysis of the anxiety upon awakening assessment questionnaire I. Saez-Uribarri (Bilbao, ES)

SES Meeting, Stream 4 13:30 - 16:00 SES Meeting

Poster Session, Poster, Poster Networking Lounge 13:30 - 14:30 Poster Networking Lounge - open to visit

P301 Prevalence of comorbidities in OSA - COPD overlap syndrome patients in a cohort from Western Romania S. Mihaicuta (Timisoara, RO)

P302 Prevalence and risk factors for obstructive sleep apnea in truck drivers Â. Dias Cunha (Viseu, In the USA or Canada, please select..., PT)

P303 Risk factors for non-compliance with continuous positive airway pressure in patients with obstructive sleep apnea and paroxysmal atrial fibrillation G.M. Traaen (Oslo, NO)

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P304 Sleep, obstructive sleep apnea and cardiometabolic health in an aging rural community in South Africa J. Roche (Johannesburg, ZA)

P305 Epworth Sleepiness Scale and STOP-Bang questionnaire as screening tools for obstructive sleep apnea C. Pimentel (Leiria, PT)

P306 Peripheral biomarkers of obstructive sleep apnea in Alzheimr's disease patients G. Piñol (Lleida, ES)

P307 Actigraphic analysis of sleep and circadian disturbance in premanifest Huntington's disease: sleep period activity increases progressively and predicts motor outcome T. Lopez (Cambridge, UK)

P308 Morphological measures of sleep spindles as a biomarker of Parkinson's disease L.M. Nilsson (Kongens Lyngby, DK)

P309 The potential of bright light treatment in the management of depression and anxiety in dementia during winter E. Kolberg (Bergen, NO)

P310 Unfavourable cardiovascular profile is associated with sleep-wake disturbances and predicts future cardio-cerebrovascular events in stroke patients I. Filchenko (St Petersburg, RU)

P311 The bidirectional relations between sleep and psychosocial difficulties from age 12 to 18 in Finnish adolescents L. Kortesoja (Helsinki, FI)

P312 Nightmares and anxiety upon awakening during the crisis caused by the Covid-19 pandemic I. Saez-Uribarri (Bilbao, ES)

P313 Spectral EEG bands and dreams J. Pires (Amadora, Lisboa, PT)

P314 Sleep deprivation as a remedy for major depression: biochemical mechanisms A. Kalinchuk (Rostov-on-Don, RU)

P316 Effect of Sudarshan Kriya Yoga on sleep propensity in novice practitioners K. Chaudhari (Mumbai, Maharashtra, IN)

P317 Relationship between waking theta power and the present and prior sleep wake activity Z. Lelkes (Szeged, HU)

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P318 Can auditory slow wave stimulation during chronic sleep restriction intensify subjective recovery? N. Schneider (Zurich, CH)

P319 Sleep apnea and heart shock protein 70 (HSP 70): pilot study I. Madaeva (Irkutsk, RU)

P320 Entrainment of the circadian system to an extremely long photoperiod: summer camping at high latitude (~63°n) J. Axelsson (Stockholm, SE)

Oral Session, Oral Session, Stream 1 13:45 - 14:45 Oral Session 9 – Chronobiology & Circadian Disorders

Chairs G. Vandewalle (Liege, BE) T. DeBoer (Leiden, NL)

13:45 - 13:55 O73 Learning management system logins at a large university show that late type students have poorer grades irrespective of class start time J. Gooley (Singapore, SG)

13:55 - 14:05 O74 Melatonin might influence the circadian regulation of the retina in patients with REM sleep behavior disorder O. Steiner (Berlin, DE)

14:05 - 14:15 O75 Blue enriched white light exposure during 40 hours of extended wakefulness does not alter recovery sleep in healthy young adults R. Glacet (Strasbourg, FR)

14:15 - 14:25 O76 The acute effects of sleep restriction therapy for insomnia on circadian timing: a within-subjects evaluation of phase angle L.F. Maurer (Oxford, UK)

14:25 - 14:35 O77 Sleep restriction effects on object-location-associative-memory performance: a randomized controlled sleep deprivation versus multinap study in healthy elderly at low and high genetic risk of Alzheimer's A. Michalak (Norwich, Norfolk, UK)

14:35 - 14:45 O78 Ultradian light-dark cycle: a circadian-time dependent influence on the distribution and quality of sleep and waking F. Fuchs (Strasbourg, FR)

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Wednesday, 23 September 2020

Neurology, Symposium, Stream 2 13:45 - 14:45 Hypocretins/orexins and cardiovascular disease risk: narcolepsy type 1 and beyond

Cardiovascular diseases are the number 1 cause of death globally, with atherosclerosis burden and autonomic alterations among key promoting factors. Cardiovascular diseases are being increasingly associated with sleep disorders, but potential mechanistic links are still unclear. This symposium shall integrate different lines of evidence on the role of hypocretins/orexins in linking cardiovascular disease risk with sleep disorders. The symposium will include a short introduction by the chairpersons, four presentations bringing together adult and paediatric clinical science and epidemiology with basic animal research, and a final comprehensive discussion. The introduction will focus on the role of hypocretins/orexins in the central autonomic network and on arterial blood pressure alterations during sleep in hypocretin/orexin-deficient mouse models of narcolepsy type 1 (NT1). This will set the stage for the first and second presentations, which will discuss recent findings on cardiovascular and autonomic alterations in adult and paediatric patients with NT1. The third presentation will update the audience on the epidemiology of cardiovascular morbidity and mortality in these patients. The last presentation will discuss exciting new evidence demonstrating that reduced hypocretin/orexin signalling underlies increased atherosclerosis burden in mouse models not only of NT1, but also of long-term sleep fragmentation, which is a common feature of multiple sleep disorders beyond NT1. This symposium will thus be of interest to a multidisciplinary audience including neurologists, paediatricians, cardiologists, and basic researchers, and will foster cross-disciplinary interactions with the potential of developing hypocretin/orexin signalling as a druggable target for cardiovascular disease prevention and therapy in patients with sleep disorders.

Chairs A. Silvani (Bologna, IT)

13:45 - 14:00 O79 Novel findings on cardiovascular and autonomic alterations in paediatric patients with narcolepsy type 1 F. Pizza (Bologna, IT)

14:00 - 14:15 Cardiovascular and autonomic alterations in adult patients with narcolepsy type 1: an update L. Barateau (Montpellier, FR)

14:15 - 14:30 Cardiovascular morbidity and mortality in adult and paediatric patients with narcolepsy type 1: an update P. Jennum (Glostrup, DK)

14:30 - 14:45 O80 Systemic inflammatory networks and atherosclerosis burden in mouse models of sleep fragmentation and narcolepsy type 1 C. McAlpine (Boston, US)

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Wednesday, 23 September 2020

Human Basic, Symposium, Stream 3 13:45 - 14:45 Contributions of sleep to daytime functioning, well-being and cognitive fatigue

Sleep undeniably contributes to daytime functioning and wellbeing. This might be particularly true under conditions of mental or cognitive overload. Recent models in cognitive neurosciences attempt to explain how life-course factors and environmental stressors, combined with adverse or protective neural processes, can produce variable levels of neurobehavioral function, ranging from high-level alertness and focused attention on a specific cognitive task to mind wandering and drowsiness. In this symposium, we will address associations between sleep, daytime functioning or well-being and varying levels of cognitive fatigue. The thematic will be explored under different angles by combining paradigms from basic human sleep research and cognitive neurosciences. Dr. F. Collette will address the role of experimentally induced cognitive fatigue on working memory performance and compensatory neural processes over life-span. Dr. P. Peigneux will speak about the association between cognitive fatigue, sleep and cortical activity under conditions of sleep deprivation and in multiple sclerosis disease. Dr. F. Van Opstal will complete the picture by presenting data on the inter-connections between sleep and mind wandering over daytime. Finally, Dr. L. Thiesse will assess the impact of noise as an environmental nuisance factor for sleep and metabolic function. The proposal integrates novel findings using a variety of protocols that apply behavioral paradigms, brain imaging, electrophysiological monitoring and hormonal assays to characterize pathways by which sleep contributes to overall daytime functioning and quality of life. The data will be discussed within the frame of recently developed models in cognitive neurosciences and emphasize on the importance of sleep for mental health.

Chairs C. Schmidt (Liège, BE) F. Collete (Liège, BE)

13:45 - 14:00 O81 How does cognitive fatigue affect young, middle-aged, and older people at the behavioral and brain level? F. Collette (Liège, BE)

14:00 - 14:15 O82 Local slow-wave activity and its relation to mind-wandering F. van Opstal (Amsterdam, NL)

14:15 - 14:30 Sleep and cognitive fatigue in healthy and pathological conditions P. Peigneux (Bruxelles, BE)

14:30 - 14:45 O83 The impact of noise on sleep and cardio-metabolic markers L. Thiesse (CH)

Poster Session, Poster, Poster Networking Lounge 14:30 - 15:30 Poster Networking Lounge - open to visit

P321 Assessing the predictive potential of neck circumference for diagnostic and CPAP treatment response in OSAS with network medicine S. Mihaicuta (Timisoara, RO)

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P322 Validation study of an innovative device to screen sleep respiratory disorders A. Braghiroli (Gattico-Veruno, Novara, IT)

P323 Oxygen desaturations index (ODI) as a marker for intermittent hypoxia and its relationship to cardiovascular risk factors R.C. Mateo-Montero (Barcelona, ES)

P324 Electroencephalographic findings during sleep in apneic obese adolescents O. Berdina (Irkutsk, RU)

P325 Comparison of multiple sleep disorder questionnaires as stand-alone sleep surveillance tools K. Chaudhari (Mumbai, Maharashtra, IN)

P326 Differential spindle expression dependent upon thalamic nuclei lesioned by stroke J.L. Jendoubi (Bern, CH)

P327 Sleep homeostasis and excessive daytime sleepiness in Parkinson disease S.J. Schreiner (Zurich, CH)

P328 CSF Orexin as biomarker of neurodegeneration: a systematic review and analysis R. Riha (Edinburgh, UK)

P329 Ambient bright light treatment improved subjectively measured sleep but not sleep measured by actigraphy in nursing home patients with dementia: a placebo-controlled randomized trial G.J. Hjetland (Bergen, Hordaland, NO)

P330 Early-night slow-wave sleep potentiation is disrupted in anti-N-methyl-D- aspartate receptor encephalitis and schizophrenia K. van Welzen (Barcelona, ES)

P331 How did you sleep? Exploring by-proxy sleep assessment in a field study setup T. Vacaretu (Eindhoven, Noord-Brabant, NL)

P332 BAMSA - an easy method to evaluate the possibility of sleep apnea among male professional drivers R. Huhta (Helsinki, FI)

P333 'Dethroning the King': comparative sensitivity of the PVT and a behavioral sleep resistance test to sleep deprivation in healthy subjects and CPAP-treatment in OSAS patients O. Mairesse (Brussels, BE)

P334 Dynamics of daytime multiple sleep latency tests in individuals with different PER3 VNTR genotypes E. Lambot (Liège, BE)

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P335 Gender differences in the adjustment to night shift work R.M. Lecca (Cagliari, IT)

P336 Sleep in the European Jackdaw (Coloeus monedula) D. Martinez-Gonzalez (Seewiesen, DE)

P337 Changes in slow-wave traveling after phase targeted auditory stimulation of the up and down phase of sleep slow waves G. Sousouri (Zurich, CH)

P338 Differences in circadian variation of melatonin and antioxidant capacity in breast milk according to the type of delivery V. Martin-Carbonell (Valencia, Valencia, ES)

P339 Effects of sleep loss and time of day on postural control: a randomized controlled sleep deprivation versus multi-nap study in healthy older men and women Z. Shabana (Norwich, Norfolk, UK)

P340 Effects of official time in sleep and circadian rhythms in elderly populations of border towns in Spain and Portugal M.Á. Bonmatí-Carrión (Murcia, ES)

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Neurology, Symposium, Stream 2 15:00 - 16:00 The neural correlates of central disorders of hypersomnolence

Central disorders of hypersomnolence, including narcolepsy type 1 and 2 and idiopathic hypersomnia are mainly characterized by excessive daytime sleepiness. This symposium will put basic neuroimaging research into a clinical perspective. It will shed light on the neural mechanisms related to excessive daytime sleepiness and emotional dysregulation in central disorders of hypersomnolence. The neural profiles of narcolepsy type 1 and 2 and idiopathic hypersomnia will be compared and insights given on how neuroimaging could improve current disease understanding and diagnostic criteria. Multiple sleep-wake states will be covered, including regulation of sleepiness, sleep, alertness and vigilance. Chair: Dr. Lammers (The Netherlands) will give a short introduction on the current diagnostic pitfalls of central disorders of hypersomnolence and the potential for neuroimaging to address these challenges Speaker 1: Jari Gool (The Netherlands) will review recent imaging findings on the two narcolepsy types, highlighting neural mechanisms underlying the sleepiness and cognitive characteristics of both disorders Speaker 2: Dr. Juvodden (Norway) will present recent work on the structural and functional neuroimaging profile of post-H1N1 narcolepsy Speaker 3: Dr. Dang-Vu (Canada) will provide an overview of the latest idiopathic hypersomnia insights including structural and functional connectivity and brain perfusion abnormalities in patients compared to healthy sleepers Speaker 4: Dr. Khatami (Switzerland) will present electrophysiological high-density EEG data on humour and reward processing in patients with narcolepsy and idiopathic Parkinson´s disease compared to healthy subjects to provide insights into the role of hypocretin and dopamine in emotional and reward regulation.

Chairs G.J. Lammers (Heemstede, NL)

15:00 - 15:15 The neural correlates of narcolepsy type 1 and 2 J. Gool (Amsterdam, NL)

15:15 - 15:30 The structural and functional brain profile of post-H1N1 narcolepsy H. Juvodden (Oslo, NO)

15:30 - 15:45 Brain connectivity and perfusion abnormalities in idiopathic hypersomnia N. Cross (Montreal, QC, CA)

15:45 - 16:00 The high-density EEG correlates of the hypocretin and dopamine systems in relation to emotional and reward processing in narcolepsy and idiopathic Parkinson's disease R. Khatami (Barmelweid, CH)

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Wednesday, 23 September 2020

Human Basic, Symposium, Stream 3 15:00 - 16:00 Circadian rhythms, sleep and metabolic health

Two concurrent health trends have emerged over the last decades with major effects on society and health care systems: an increase in the incidence and severity of obesity and metabolic diseases, and a rise in chronic sleep debt. Numerous studies have linked altered sleep time and adverse metabolic outcomes. Importantly, many aspects of metabolism display ~24-h circadian rhythms, including 24-h variations in glucose control and appetite-related measures. In our symposium, we will integrate the importance of circadian and sleep processes on metabolic health, using basic human research and clinical work in insomnia patients. Dr. Steven Brown (University of Zurich) will discuss how daily circadian and sleep-regulated control of stress-related nuclear speckles are essential for both normal sleep physiology and metabolism at the cellular and tissue levels. Shift workers experience mistimed sleep and eating patterns and have an increased risk for diabetes. Dr. Sarah Chellappa (Harvard University) will show how appropriate meal timing may circumvent the adverse metabolic consequences of shift work schedule. Dr. Marta Garaulet (University of Murcia) will address the importance of timing of food intake relative to sleep timing in obesity and metabolic health. Lastly, Dr. Tamar Shochat (Haifa University) will discuss how dietary-induced changes in gut microbiome may be associated with changes in sleep in older age, and that personalized diet affects gut microbiota, sleep, and daytime functioning in older insomnia patients. Collectively, our symposium will provide compelling evidence for and translational relevance of the central role of circadian and sleep mechanisms to promote optimal metabolic health.

Chairs T. Shochat (Haifa, IL)

15:00 - 15:15 Nuclear Reorganisations Controlling Sleep and Metabolism S. Brown (Zurich, CH)

15:15 - 15:30 Meal timing regulates the circadian plasma metabolome in humans J. Johnston (Guildford, Surrey, UK)

15:30 - 15:45 Circadian rhythms, obesity and weight loss M. Garaulet (Murcia, ES)

15:45 - 16:00 Do changes in nutrition improve sleep in older adults with insomnia? The role of gut microbiota and daytime functioning T. Shochat (Haifa, IL)

Poster Session, Poster, Poster Networking Lounge 15:30 - 16:30 Poster Networking Lounge - open to visit

P342 Postural aspects and polysomnography D. Cugy (Bordeaux, FR)

P343 Role of hypocretin-orexin signaling in autonomic cardiovascular dysfunction in narcolepsy with cataplexy K. Chaudhari (Mumbai, Maharashtra, IN)

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Wednesday, 23 September 2020

P344 The association between self-reported short sleep duration and lipoprotein (a) L. Korostovtseva (St Petersburg, RU)

P345 Accelerometer-measured catch-up sleep on non-working days among older employees S. Myllyntausta (Joensuu, FI)

P346 Daytime sleepiness prevalence and its association with psychosocial problems in Russian urban adolescents: a school-based study with age- corrected Pediatric Daytime Sleepiness Scale cut-offs S. Tereshchenko (Krasnoyarsk, Красноярский кр&, RU)

P347 Influence of chronic radiofrequency electromagnetic fields exposure on autonomic nervous activity during sleep in preterm neonates: preliminary results D. Besset (Amiens, FR)

P348 Sleep ecology and sleep patterns among infants and toddlers: a cross- cultural comparison between the Arab and Jewish societies in Israel G. Zreik (Emek Yezreel, IL)

P349 Effects of an online CBT-I treatment for pediatric sleep problems on emotion dysregulation in young children: findings from the web-based sleep intervention program Mini-KiSS online F. Lollies (Bielefeld, DE)

P350 The mediating role of sleep in the relationship between childhood trauma and dissociation A.S.-Y. Ng (Hong Kong, HK)

P351 Validation of the Armenian version of the Pittsburgh sleep quality index H. Hovakimyan (Yerevan, AM)

P352 Validation of the Armenian version of the Berlin questionnaire H. Hovakimyan (Yerevan, AM)

P353 Reciprocal associations between sleep, mental strain and training load in junior endurance athletes, and the role of poor subjective sleep quality M. Hrozanova (Trondheim, NO)

P355 Sleep during 'lockdown' in COVID 19 pandemic G. Trakada (Athens, GR)

P356 Impact of evening smartphone use and emotion regulation on circadian rhythm and sleep S.R. Schmid (Salzburg, AT)

P357 Assessing objective sleep quality in insomnia patients with an index based on age norms T.A. Thomas (Düsseldorf, DE)

P358 Daytime sleep features of habitual and non-habitual nappers D. Bergamo (Padova, IT)

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Wednesday, 23 September 2020

P359 Effect of sleep on metabolic health G. Zhu (Newcastle upon Tyne, UK)

P360 Adolescents' lived experience of sleeping difficulties M. Jakobsson (Borås, SE)

Keynote, Keynote Lecture, Stream 1 16:30 - 17:15 Keynote Lecture - M. Nedergaard, US

Chairs H.-P. Landolt (Zurich, CH)

16:30 - 17:15 The glymphatic system, sleep and neurodegenerative diseases M. Nedergaard (US)

Poster Session, Poster, Poster Networking Lounge 16:30 - 17:30 Poster Networking Lounge - open to visit

P361 Association between REM sleep microarchitecture and grey matter in the hippocampus and entorhinal cortex of late middle-aged and older adults with obstructive sleep apnea M.-E. Martineau-Dussault (Montreal, QC, CA)

P362 Effects of short- and long-term solriamfetol treatment on adherence to primary obstructive sleep apnoea therapy P.K. Schweitzer (Chesterfield, MO, US)

P364 The return of the nap: daytime sleep benefits procedural memory in older adults B. Toor (Ottawa, ON, CA)

P365 Associations between tau protein levels and self-reported sleep quality in older adults with and without cognitive complaints A.A. Perrault (Montreal, QC, CA)

P366 Interictal epileptic activity disrupts sleep: a combined stereo electroencephalography and polysomnography study L. Peter-Derex (Montreal, QC, CA)

P367 Clinically relevant effects of solriamfetol on excessive daytime sleepiness: post hoc analyses of clinical trials in narcolepsy or obstructive sleep apnoea R. Rosenberg (Atlanta, GA, US)

P368 Subtle cognitive deficits are associated with brain atrophy in isolated rem sleep behavior disorder S. Rahayel (Montreal, QC, CA)

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Wednesday, 23 September 2020

P369 A gene first approach toward understanding sleep disturbances in autism R. Tesfaye (Montreal, QC, CA)

P370 Sodium oxybate treatment effects on sleep architecture in paediatric patients with narcolepsy with cataplexy E. Mignot (Palo Alto, US)

P371 Is human sleep duration adaptive to social activity? B.C. Holding (Stockholm, SE)

P372 Effect of pharmacological and non-pharmacological treatment on sleep pattern and serum iron levels in an animal model of Restless Legs syndrome A. Esteves (Limeira, BR)

P373 The Impact of COVID-19 suppression measures on objectively measured sleep L. Gahan (Carlsbad, CA, US)

P374 Sleep quality and insomnia symptoms during the COVID-19 pandemic in a Brazilian rural population T. Taporoski (Chicago, IL, US)

P375 Effect of the selective melatonin MT1 receptor partial agonist ucm871 in the activity of norepinephrine neurons of the locus coeruleus during the sleep/wake cycle M. Lopez-Canul (Montreal, QC, CA)

P377 Sleep architecture in mice lacking the immunoglobulin superfamily member 21 T. Leduc (Montréal, QC, CA)

P379 EEG and behavioural correlates of mild sleep restriction and vigilance A. Gibbings (Ottawa, ON, CA)

P380 Parental sleep of 6-month-olds: do primiparas and multiparas differ? S. Kenny (Montreal, QC, CA)

Keynote, Keynote Lecture, Stream 1 17:30 - 18:15 Keynote Lecture - R. Benca, US

Chairs T. Paunio (Helsinki, Finland, FI)

17:30 - 18:15 O84 La vida es sueño: sleep and psychiatry R. Benca (US)

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Wednesday, 23 September 2020

Poster Session, Poster, Poster Networking Lounge 17:30 - 18:30 Poster Networking Lounge - open to visit

P381 Polysomnographic pilot study of a new mandibular oral device for mild to moderate obstructive sleep apnea M. Manconi (Lugano, CH)

P382 Effect of obesity on anthropometric features between Asian and Caucasian population with obstructive sleep apnea: a cumulative meta- analysis H. Qin (Berlin, DE)

P383 Prediction of sleep disordered breathing in acute stroke patients: questionnaires cannot replace objective respiratory testing M. Dekkers (Bern, CH)

P384 Prevalence and determinants of sleepiness in obstructive sleep apnea patients K. Baou (Athens, GR)

P385 Tonsilar hypertrophy and severity of obstructive sleep apnea in adults K. Baou (Athens, GR)

P386 Long-term effects of solriamfetol on quality of life in participants with excessive daytime sleepiness associated with narcolepsy or obstructive sleep apnoea M. Baladi (Palo Alto, CA, US)

P387 Multimodal assessment of sleep misperception in chronic primary insomnia A.A. Perrault (Montreal, QC, CA)

P388 Heart rate changes in young adults with insomnia watching humorous films: an exploratory study C. Bastien (Quebec, QC, CA)

P389 Insomnia symptoms severity is associated with worse cognitive performance: the moderating effect of biomarkers of dementia risk factors A.-A. Baril (Boston, MA, US)

P390 The effect of CBTi on subjective and objective cognitive performance in chronic primary insomnia F.B. Pomares (Montreal, QC, CA)

P391 The impact of COVID-19 awareness and subsequent daily life changes on weekday and weekend sleep patterns in the USA L. Gahan (Carlsbad, CA, US)

P392 The global connection between happiness and a good night's sleep: a big data analysis L. Gahan (Carlsbad, CA, US)

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Wednesday, 23 September 2020

P393 Fragrance affects self-reported and objectively measured sleep in healthy women: a double-blind, placebo-controlled crossover field study H. Rus (Carlsbad, CA, US)

P394 Long shift duration is associated with high risk for Shift Work Disorder H.M. Lammers-van der Holst (Boston, MA, US)

P395 Epworth scale - a method for OSAS severity stratification? M. Oliveira (Guarda, PT)

P396 A role for cellular stress in age-related sleep impairments and cognitive decline J. Hafycz (Philadelphia, PA, US)

P397 Pupillometry is a promising noninvasive method for determining lighting effects on human physiology J. de Zeeuw (Berlin, DE)

P398 Rapid fast-delta decay following prolonged wakefulness marks a phase of wake-inertia in NREM sleep in both mice and humans J. Hubbard (Lausanne, CH)

P399 Sleepcoaching: non-pharmacological treatment of non-restorative sleep in Austrian railway shift workers B. Holzinger (Vienna, AT)

P400 Hypocretin-orexin and melanin concentrating hormone interplay in narcolepsy K. Chaudhari (Mumbai, Maharashtra, IN)

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Wednesday, 23 September 2020

Human Basic, Symposium, Stream 1 18:30 - 19:30 Tweaking the ‘spectral diet’: optimising light exposure for better sleep

Light enables humans to perceive form, colour and motion of the environment thus allowing us to interact with it. But in addition, light also has profound non- visual effects on our physiology, specifically our circadian system, thereby also impacting on sleep. In this context, the timing of light exposure as well as the spectral composition of light are crucial. Dr. Spitschan will present novel insights on how and to what extent these aspects are mediated by the different short- wavelength-sensitive photoreceptors in the human retina. In a laboratory study, Dr. Blume investigated the effects of specific artificial light settings (i.e. low vs. high melanopic screen light) on sleep quality and human brain functions such as cortical communication and temporal integration during pre-sleep evening light exposure and subsequent sleep. Her findings will be complemented by Prof. Wright, who examines the influence of light on circadian timing on physiology and cognition in laboratory as well as field studies. Importantly, such knowledge can then further be used to design individualised “light diets”. To this end, Prof. Skeldon uses mathematical models combining the interaction of light with circadian rhythmicity, sleep homeostasis and social schedules. Recent results by for example suggest that (i) seasonal changes in sleep timing and synchrony in schizophrenia can be explained by seasonal changes in light exposure patterns and (ii) appropriate light interventions to stabilise sleep and circadian rhythmicity.

Chairs C. Blume (Basel, CH)

18:30 - 18:43 Statistical regularities in light exposure and the role of the different photoreceptors in driving the circadian system M. Spitschan (Oxford, UK)

18:43 - 18:45 Q&A

18:45 - 18:58 O85 Effects of pre-sleep artificial light exposure on fundamental cognitive processes C. Blume (Basel, CH)

18:58 - 19:00 Q&A

19:00 - 19:13 Effect of alterations in real world light exposure on mood, sleepiness, and performance K. Wright (Boulder, US)

19:13 - 19:15 Q&A

19:15 - 19:28 O86 Mathematical modelling of light, sleep and circadian rhythmicity applied to schizophrenia A. Skeldon (Guildford, UK)

19:28 - 19:30 Q&A

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Wednesday, 23 September 2020

Neurology, Symposium, Stream 2 18:30 - 19:30 The neurophysiology of RBD: from the brainstem and beyond

This symposium will focus on clinical and preclinical studies on the neurophisiological REM sleep alterations. In particular, emphasis will be placed on REM behavior disorder, a parasomnia characterized by complex and often violent motor behaviors during REM sleep, which has been found to be a robust clinical predictor of neurodegenerative conditions, such as Parkinson’s disease and other alpha-synucleinopathies. Prof. Luppi will discuss about the animal model of paradoxical sleep (PS) focusing on the RSWA circuitry. Prof. Bortolato will ill present his studies on early startle alteration in animal models of sleep deprivation and its correlates in neurodegeneration. Dr. Lanza will explore intracortical inhibition measured by means of transcranial magnetic stimulation (TMS) and its correlation with REM Sleep Atonia Index in isolated RBD patients showing an electrocortical pattern similar to that reported in the early stage of Parkinson’s disease that might precede the onset of a future neurodegenerative disorder Prof. Puligheddu will discuss the role of Vestibular Evoked Miogenic Potential and Startle Reflex in the exploration of brain stem neurodegeneration both in isolated REM sleep behavior disorder and in Parkinson’s disease RBD, and indicate potential pathophysiological links between these disorders.

Chairs R. Ferri (Troina, IT)

18:30 - 18:45 The neural network underlying Rem sleep without atonia (RSWA) P.-H. Luppi (Lyon, FR)

18:45 - 19:00 TMS and cortical excitability in Rem behaviour disorder G. Lanza (Catania, IT)

19:00 - 19:15 Vestibular evoked myogenic potentials and Startle Reflex in iRBD and PD- RBD M. Puligheddu (Cagliari, IT)

19:15 - 19:30 Discussion

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Wednesday, 23 September 2020

Pediatric Medical Disorders, Symposium, Stream 3 18:30 - 19:30 The borderland between wakefulness and sleep

Despite revisions and adaptations of wake-sleep scoring criteria, the clinical approach on how to assess sleep and wake functions has barely changed in the past decades. On the other hand, the concept of sleep and wakefulness is changing, particularly with respect to topography and temporal resolution. However, evidence systematically investigating local aspects as well as shorter periods of wakefulness and sleep, i.e. microsleep episodes, is still sparse. Nevertheless, existing evidence indicates that these conceptual changes might not only expand the understanding of neurophysiological wake-sleep processes but also help to improve the understanding of severe sleepiness (including sleep deprivation) and differential diagnosis of disorders resulting in excessive daytime sleepiness (mainly CNS hypersomnolence disorders). Furthermore, the effects of these conceptual changes on various brain functions, such as performance, need to be determined and subsequent implications clarified, e.g. for fitness to drive. Integrating basic and clinical perspectives, the proposed translational symposium aims to challenge the traditional wake-sleep concept by highlighting new insights and hypotheses on the impact of topographical changes during sleep (R. Huber), the borderland between wakefulness and sleep (D. Schreier) with respect to cortical but also subcortical brain structures (L. Nobili), and new imaging and neurophysiological correlates of CNS hypersomnolence disorders (R. Fronczek).

Chairs D. Schreier (Bern, CH)

18:30 - 18:45 Local aspects of sleep R. Huber (Zurich, CH)

18:45 - 19:00 O87 Microsleep episodes in the vigilance assessment D. Schreier (Bern, CH)

19:00 - 19:15 Dissociation between cortex and deeper brain structures L. Nobili (Milan, IT)

19:15 - 19:30 O88 Redefining CNS hypersomnolence disorders R. Fronczek (Leiden, NL)

General, Other Session, Stream 1 19:45 - 21:30 Business Meeting

For ESRS members only - online voting

This year's ESRS Business Meeting will be held as an online session with ZOOM. All ESRS members will receive a link to the meeting right in time. In order to give all participants, ESRS board and staff enough time for the check-in, the ZOOM meeting room will open at 19:00 CEST.

The agenda and the invitation will be sent to all ESRS members by the ESRS society.

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Thursday, 24 September 2020

General, Virtual Exhibition 08:00 - 18:30 Virtual Exhibition - open to visit

Oral Session, Oral Session, Stream 1 08:30 - 09:45 Oral Session 10 - Sleep disordered breating: comorbidities and symptoms

Chairs J. Hedner (Gothenburg, SE) A. Patacka (GR)

08:30 - 08:40 O89 Pitolisant evaluation in obstructive sleep apnea patients treated by nasal continuous positive airway pressure but still complaining of excessive daytime sleepiness J.L. Pépin (Grenoble, FR)

08:40 - 08:50 O90 Effects of solriamfetol on driving performance in participants with excessive daytime sleepiness associated with obstructive sleep apnoea F. Vinckenbosch (Maastricht, NL)

08:50 - 09:00 O91 The effect of armodafinil on sleep spindles in obstructive sleep apnea: secondary analyses of a randomised placebo-controlled trial L. Emami (Sydney, NSW, AU)

09:00 - 09:10 O92 Obstructive sleep apnea impacts on hallmarks of cellular and molecular aging L.S. Gaspar (Coimbra, PT)

09:10 - 09:20 O93 Chronic thromboembolic pulmonary hypertension: improvement of sleep- disordered breathing after balloon pulmonary angioplasty K. Hackner (Krems, AT)

09:20 - 09:30 O94 A network-based analysis of the association between comorbidities in patients with obstructive sleep apnea using the ESADA network database P. Steiropoulos (Alexandroupolis, GR)

09:30 - 09:40 O95 Early sleep apnea termination by bone-conducted sound stimulation, a new approach to treat obstructive apnea? A. Waeber (Lausanne, Vaud, CH)

Roundtable, Round Table, Stream 2 08:30 - 09:45 Round table ANSS/ESRS

Chairs Y. van der Werf (Amsterdam, NL) S. Khachatryan (Yerevan, AM)

08:30 - 08:48 Role of sleep and its disorders for public health O.C. Deleanu (Bucuresti, RO)

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08:48 - 09:06 Sleep-disordered breathing and cardiovascular risk L. Korostovtseva (St Petersburg, RU)

09:06 - 09:24 Smoking and sleep J. Verbraecken (Antwerp, BE)

09:24 - 09:42 Future perspectives of ANSS as an ESRS branch B. Strazisar (Ljubljana, SL)

Oral Session, Oral Session, Stream 3 08:30 - 09:45 Oral Session 11 - Learning & Memory

Chairs K. Hoedlmoser (Salzburg, AT) C. Schmidt (Liège, BE)

08:30 - 08:40 O96 Impact of wake fragmentation on working memory performance and associated cerebral correlates in the aged M. Reyt (Liège, BE)

08:40 - 08:50 O97 Effect of targeted memory reactivation on electrophysiological sleep features involved in motor memory consolidation J. Nicolas (Leuven, BE)

08:50 - 09:00 O98 The effect of sleep on associative novel word learning in healthy young adults E. Schimke (Brisbane, QLD, AU)

09:00 - 09:10 O99 Sleep benefits memory retention by enhancing functional brain activity in the posterior medial memory network, thalamus and striatum during recall S. Brodt (Tübingen, DE)

09:10 - 09:20 O100 A longitudinal investigation of cognitive performance and sleep spindles in young adolescents C. Reynolds (Adelaide, SA, AU)

09:20 - 09:30 O101 Sleep to stop the decline of planning and risk-related decision-making ability during the day M.L. Wong (Exeter, UK)

09:30 - 09:40 O102 The preferential processing of relevant sounds continues during NREM sleep M.S. Ameen (Salzburg, AT)

Poster Session, Poster, E-poster library 08:30 - 19:00 E-Poster Library

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Thursday, 24 September 2020

Poster Session, Poster, Poster Networking Lounge 08:30 - 09:30 Poster Networking Lounge - open to visit

P401 Severity of oxygen desaturation in OSA - COPD overlap syndrome compared to OSA alone S. Mihaicuta (Timisoara, RO)

P402 Shared decision making in obstructive sleep apnea. Does it happen? T.C. Øverby (Lørenskog, NO)

P403 Sleep-disordered breathing and sleep quality: a Janus-faced matter J. Pinto (Porto, PT)

P404 Epidemiology of obstructive sleep apnea in HIV patients: is there any association with CD4 count A. Najafi (Tehran, Tehran, IR)

P405 The protective effect of warmer colour display of smartphone screen on sleep quality of adults W.Y. Wong (Hong Kong, HK)

P406 Parent-reported sleep onset latency is associated with increased salivary cortisol level among autism boys M. Cao (Guangzhou, Guangdong, CN)

P409 The relationship between cortical arousal and subjective insomnia symptoms in primary insomniacs S. Yu (Seoul, KR)

P410 Development and psychometric properties of a short form of the Sleep- related Behaviours Questionnaire A. Ubara (Kyotanabe-shi, JP)

P411 Updated version of the Hockey-stick program to estimate melatonin onset and offset K.V. Danilenko (Novosibirsk, RU)

P412 Sleep health promotion interventions and their effectiveness: an umbrella review U. Albakri (Maastricht, Limburg, NL)

P413 Newborns' sleep during auditory stimulation - the role of perinatal memory and stimulus familiarity M. Schabus (Salzburg, AT)

P415 Obstructive sleep apnea - about the differences between male and female patients J. Costa (Guarda, PT)

P416 Sleep problems across a lifespan of children, adolescents and adults with autism spectrum disorder and intellectual disability at a glance P. Ballester (Elche, ES)

P418 Individualized thresholds in sleep spindle detection M. Lucchini (Manno, CH)

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Thursday, 24 September 2020

P419 Prevalence and dynamic of sleep disturbances over 30 years in Russia/Siberia: 1988-2018 years D. Panov (Novosibirsk, RU)

P420 Excessive daytime sleepiness in health professionals at an Universitary Hospital M. Pereira (Lisboa, PT)

General, Webcast Library 08:30 - 19:00 Webcast Library - open to visit

Recorded sessions of previous day

Poster Session, Poster, Poster Networking Lounge 09:30 - 10:30 Poster Networking Lounge - open to visit

P421 Digital cognitive behavioural therapy for insomnia: gender differences in dropout rates L. Retzer (Nuremberg, DE)

P422 Quality control of polysomnographic scoring in a clinical sleep physiologist team H. Engleman (Chichester, UK)

P423 Sleep, the overlooked factor in the management of T2D S. Khodabakhsh (Bristol, UK)

P424 A complex relationship between obstructive sleep apnea syndrome, inﬂammation and oxidative stress A.D. Maierean (Cluj Napoca, Cluj, RO)

P425 Maxillo-mandibular advancement surgery role in obstructive sleep apnea syndrome treatment: case series S.I. Guerra (Viseu, PT)

P426 Depression and sleep quality of obstetricians in South Korea K.T. Kim (Daegu, KR)

P427 Women are more susceptible to aging in chronic insomnia disorder J.K. Hong (Seongnam-si, Gyeonggi-do, KR)

P428 Study of relationship among fatigue, sleepiness and depression based on sleep EEG Y. Goto (Kyoto, Kyoto, JP)

P430 Moderating effects of sleep problems in the relationship between depression and suicide attempts D. Kim (Seoul, KR)

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Thursday, 24 September 2020

P431 Changes in sleep patterns in relation to hand eczema and atopy symptoms during the first year of hairdressing apprentices' education A. Koscec Bjelajac (Zagreb, HR)

P432 Lipid profile in peri- and postmenopausal women with sleep disorders N. Semenova (Irkutsk, RU)

P433 Validation of the Armenian version of the Epworth sleepiness scale M. Isayan (Yerevan, AM)

P434 Closed-loop acoustic neurostimulation during Sleep: targeting theta waves J. Patriota (Amsterdam, NL)

P436 Development of autonomic nervous system evaluation method by using heart rate variability analysis and multivariate statistical process control C. Nakayama (Kyoto, JP)

P437 The effect of wind farm noise on subjective and polysomnographically measured sleep onset latency: a pilot study T. Liebich (Adelaide, SA, AU)

P438 Reasons for sleeping difficulties as perceived by adolescents M. Jakobsson (Borås, SE)

P439 The quality of sleep in high school urban students A. Lupusor (Chișinău, MD)

P440 Sleep deprivation vs electronic devices in school children A. Lupusor (Chișinău, MD)

Respiratory, Joint Symposium, Stream 1 10:00 - 11:00 Joint ESRS - ERS Symposium: Challenges and Perspectives in Obstructive Sleep Apnoea (OSA) - time for change?

Chairs W. McNicholas (Dublin, IE) S. Schiza (Heraklion, GR)

10:00 - 10:15 Is AHI the best marker of disease severity D. Pevernagie (Gent, BE)

10:15 - 10:30 Co-morbidities in OSA - are they really a consequence of the disorder? Do they determine outcome? M. Bonsignore (Palermo, IT)

10:30 - 10:45 New approaches to disease stratification in OSA. W. Randerath (Solingen, DE)

10:45 - 11:00 Mild OSA - when and how to treat. W. McNicholas (Dublin, IE)

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Thursday, 24 September 2020

Psychiatry, Symposium, Stream 2 10:00 - 11:00 Nightmare therapy and psychiatry: from basic research to clinical applications

Nightmares are extremely dysphoric and well-remembered dreams. If these nightmares cause significant clinical distress a nightmare disorder (F51.5) should be diagnosed. Research clearly indicates that nightmare disorders often remain unrecognized and untreated, even though about 2-5% of the general population and about 30% of psychiatric populations (depression, anxiety disorders etc.) suffer from nightmares. Frequent nightmares are clinically relevant since they are associated problems such as with disturbed sleep, impaired cognitive functioning, overall wellbeing, psychopathology severity, psychosis, substance abuse, and suicide risk. In this symposium we will explain the importance of nightmares within a psychiatric context by giving a state-of-the art overview of the current knowledge about nightmare etiology and therapy. First Michael Schredl will address nightmare etiology, especially how dysfunctional beliefs contribute to overall nightmare distress – in addition to nightmare frequency. Second, Annika Gieselmann will present her finding on how cognitive avoidance during the day may contribute to nightmare etiology, with a particular focus on posttraumatic stress disorders. Third, Jaap Lancee will move toward treatment options by discussing a meta-analytic evaluation of the efficacy of the two most common treatments for posttraumatic nightmares. Fourth and finally, Thomas Maeder will illustrate how imagery rehearsal treatment for nightmares can be administered to psychiatric (in)patients and what the benefits of including nightmare therapy in standard psychiatric care are. We hope that it may stimulate the onset of new research and we hope that it will raise more awareness so that nightmares are no longer under-recognized and undertreated.

Chairs J. Lancee (Amsterdam, NL)

10:00 - 10:15 O103 Nightmare distress, nightmare frequency, and beliefs about nightmares M. Schredl (Mannheim, DE)

10:15 - 10:30 O104 Thought suppression during the day and dream quality at night in patients that suffer from PTSD A. Gieselmann (Düsseldorf, DE)

10:30 - 10:45 O105 The efficacy of imagery rehearsal therapy and prazosin in the treatment of posttraumatic nightmares: a meta-analysis J. Lancee (Amsterdam, NL)

10:45 - 11:00 O106 Treatment of nightmares in psychiatric inpatients with imagery rehearsal therapy: a randomized controlled trial T. Maeder (Zurich, CH)

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Thursday, 24 September 2020

General, Joint Symposium, Stream 3 10:00 - 11:00 Joint ESRS - EBRS Symposium

Chairs S. Brown (Zurich, CH) T. DeBoer (Leiden, NL)

10:00 - 10:15 Sleep and torpor: a strong relationship G. Zoccoli (Bologna, IT)

10:15 - 10:30 Sleep and brain maturation: from descriptive studies to a neuromodulation approach R. Huber (Zurich, CH)

10:30 - 10:45 An ancient clock facing modern times J. Meijer (Leiden, NL)

10:45 - 11:00 What the retina tells the SCN R. Lucas (Manchester, UK)

Poster Session, Poster, Poster Networking Lounge 10:30 - 11:30 Poster Networking Lounge - open to visit

P441 Obstructive sleep apnea risk assessment among diabetes type 2 population in primary care J. Silva (Tavira, PT)

P442 Prevalence of erectile dysfunction among a sample of obstructive sleep apnoea non treated patients J. Mauricio (Viana do Castelo, PT)

P443 Obese and nonobese patients - which differences in polysomnographic measures? J. Costa (Guarda, PT)

P444 Thyrohydopexy or hydroid suspension, our experience G.J. Pérez Ortega (Cádiz, CADIZ, ES)

P445 Expansion pharyngoplasty: our experience F.J. Fernandez Machin (Cadiz, ES)

P446 A multicentric, randomised, single-blind phase 2 trial to evaluate the pharmacokinetics and pharmacokinetics-pharmacodynamics of trazodone in children and adolescents with insomnia and neurodevelopmental disorders F. Torelli (Rome, IT)

P447 Non-pharmacological sleep and circadian rhythm interventions in bipolar disorder: a systematic review of randomised controlled trials L. Bisdounis (Oxford, UK)

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Thursday, 24 September 2020

P448 Magical ideations and persecutory ideas in patients with sleep disorders R. Göder (Kiel, DE)

P449 Sleep quality during covid-19 pandemic in a Portuguese cohort of respiratory patients J. Pinto (Porto, PT)

P450 The association between shift work disorder and turnover intention among nurses K.M. Blytt (Bergen, NO)

P451 Narcolepsy with cataplexy: does age at diagnosis change the clinical picture? M. Zhang (Lyon, FR)

P452 Effects of solriamfetol on driving performance in participants with narcolepsy F. Vinckenbosch (Maastricht, NL)

P453 Personality traits in children and adolescents with narcolepsy E. De Schacht (Ghent, BE)

P454 A case of Narcolepsy type 1 in a patient with paraneoplastic limbic encephalitis G. Sallemi (Bologna, IT)

P455 Variation of the motor activity profile according to sleep macro and microstructure in pediatric type 1 narcolepsy M. Filardi (Bologna, IT)

P456 Creativity in NT1 patients: clinical aspects and mental state in the prediction of creative success A. D'Anselmo (Bologna, IT)

P457 Association of sleepiness with diseases and other sleep complaints among participants of the 'Epidemiology of cardiovascular diseases in regions of Russia (ESSE-RF)' study M. Bochkarev (St Petersburg, RU)

P458 Temperature-based measurement of circadian length is associated with depressive symptoms in adolescent girls L. Kuula (Helsinki, FI)

P459 The acute effects of light on alertness, cognition, and mood: a systematic review L. Bjerrum (Bergen, NO)

P460 pyActigraphy, an open-source python package for actigraphy data visualisation and analysis G. Hammad (Liège, BE)

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Thursday, 24 September 2020

General, Symposium, Stream 1 11:15 - 12:15 Industry Symposia 3 -Predictive Methods to CPAP therapy compliance

Sponsored by BioProjet

Chairs U. Kallweit (Witten, DE) J. Duran Cantolla (ES)

11:15 - 11:20 Inroduction by chairman U. Kallweit (Witten, DE)

11:20 - 11:35 EDS management in Narcolepsy G.J. Lammers (Heemstede, NL)

11:35 - 11:50 EDS management in OSA J.L. Pépin (Grenoble, FR)

11:50 - 12:05 Benefit/risk balance for EDS management in narcolepsy I. Arnulf (FR)

12:05 - 12:15 Questions/answers

Poster Session, Poster, Poster Networking Lounge 11:30 - 12:30 Poster Networking Lounge - open to visit

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P461 Age as a correlate of subjective and objective (spectral EEG) measures of sleepiness A. Putilov (Novosibirsk, RU)

P463 Obstructive sleep apnea in Mild Cognitive Impairment: a comparative study between Alzheimer's disease, others impairments and the control group A. García (Valencia, Valencia, ES)

P464 All-cause mortality among patients with obstructive sleep apnea in the region of Łódź, Poland (2005-2019) W. Kuczynski (Lodz, polska, PL)

P465 Telemonitoring system vs APAP in the CPAP treatment follow-up. A cost- effectiveness analysis S.A. Juarros Martínez (Valladolid, ES)

P466 Resilience and its moderating role towards Narcolepsy type 1 impact on personal relationships, work and quality of life A. Mangiaruga (Bologna, Italy, IT)

P467 Within-subject variations of sleep (mis)perception in a placebo-controlled medication study L. Hermans (Eindhoven, NL)

P468 False memory formation is enhanced in insomniacs compared to good sleepers S. Malloggi (Florence, Florence, IT)

P469 A neurophysiological and neuropsychological assessment in insomniacs with severe abuse of benzodiazepines M. Manconi (Lugano, CH)

P470 Night work as a stressor - role of sleep reactivity to stress in the relationship between night work and insomnia K. Gustavsson (Warsaw, PL)

P471 Personality, cognitive emotion regulation processes and insomnia in young adults S. Carvalho Bos (Coimbra, PT)

P472 Altered functional connectivity in insomnia disorder K.V. Jespersen (Aarhus, DK)

P473 Sleep health and brain morphometry in the UK Biobank J.E. Schiel (Freiburg im Breisgau, Baden-Württemberg, DE)

P474 Different skin phosphorylated alpha-synuclein deposition predicts phenoconversion in isolated rapid-eye-movement sleep behaviour disorder (iRBD) F. Biscarini (Bologna, BO, IT)

P475 Polysomnographic parameters in recurrent isolated sleep paralysis M. Kliková (Klecany, CZ)

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P476 The "Ikelos- Rating Scale" (Ikelos-RS): description and validation of a new instrument to measure manifestation and change of RBD symptoms over time S. Stotz (Berlin, DE)

P477 Prevalence and characteristics of sleep paralysis in the Italian University students N. Cellini (Padova, PD, IT)

P478 Neuropsychological and behavioral profile of patients with sleep-related hypermotor epilepsy (SHE) and patients with disorders of arousal (DOA) M. Figorilli (Cagliari, IT)

P479 REM sleep without atonia in patients with idiopathic REM sleep behavior disorder and Parkinson disease patients with and without REM sleep behavior disorder P. Perinova (Prague, CZ)

P480 Impaired autonomic function in patients with REM sleep behavior disorder as a marker of progression? W. Hermann (Rostock, DE)

Respiratory, Symposium, Stream 1 12:30 - 13:30 Convergence of medical and dental sleep medicine: moving toward a distinct interdisciplinary field

The collaboration between physicians and dentists has been evolving for close to 3 decades in the management of conditions such as sleep apnea, sleep bruxism, gastroesophageal reflux disorders, insomnia and orofacial pains. Sleep physician have obvious expertise in the diagnosis and management of sleep-disordered breathing, whereas dentists are health care providers that see healthy and unhealthy populations of all ages. They have the opportunity to screen for risk of sleep breathing disorders and to direct patients for further evaluation. However, since sleep disorders can overlap, the assessment of health risk and choice of treatment can be complex. Machine learning has revealed some putative associations between sleep conditions listed above, some of these associations are gender and age related. Many basic science and epidemiologic findings support that medical and dental collaboration is essential to achieve the best benefit for patient. The objective of this symposium is to review new research and clinical evidences on diagnosis, management and explore future directions of interdisciplinary collaborations between sleep physicians, psychologists, physical/exercise therapists and dentists.

Chairs G. Lavigne (Montreal, CA)

12:30 - 12:42 Chair opening remarks G. Lavigne (Montreal, CA)

12:42 - 12:54 O107 CPAP or oral appliances for OSA: time for a personalised approach P. Cistulli (Sydney, AU)

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12:54 - 13:06 O108 Sleep bruxism and sleep comorbidities: a dental-medical perspective G. Aarab (Amsterdam, NL)

13:06 - 13:18 What machine learning can teach us: overlap or not between insomnia, sleep apnea and sleep bruxism C. Dal Fabbro (Sao Paulo, BR)

13:18 - 13:30 O109 Challenges in dental sleep medicine for the 2020 Decade: a PhD student perspective A. Herrero Babiloni (Montreal, CA)

Psychiatry, Symposium, Stream 2 12:30 - 13:30 Sleep as resource of mental health

Healthy sleep has a pivotal role for maintenance of mental health, and sleep disorders, such as insomnia or sleep apnea, have a high impact on development and trajectories of mental disorders. However, the saluto- or pathogenetic mechanisms of sleep are widely unclear. Eus van Someren proposes that REM sleep with the silenced locus coeruleus and a time-out of noradrenalin provides the brain with unique neuromodulatory conditions for synaptic plasticity. By contrast, restless REM sleep with incomplete noradreanalin time-out may impede synaptic plasticity processes and consequently the recovery from mental disorders. Consequently, Thorsten Mikoteit will present studies of new REM-sleep derived biomarkers for occurence and treatment outcome of major depression: REM-sleep related heart rate variability and QEEG derived prefrontal theta cordance in REM- sleep are associated to both, aberrant noradrenergic activity as well as insufficient frontocingulate regulation of amygdala activity, and provide biomarkers of remarkable accuracy. Further, Adam Wichniak will focus on subjective and objective sleep in schizophrenia. He investigated the comorbidity and relationships between specific sleep disturbances, psychopathology and effects of antipsychotics treatment. By conclusion, patients with schizophrenia are at high risk of sleep apnea and should be effectively screened for this in daily psychiatric practice. Finally, Jana Koprivova will present a study examing the effects of the psychedelic drug psilocybin, a new antidepressant approach, on subjective and objective sleep characteristics. She proposes that part of the antidepressant drug actions may rely on changes of REM sleep and possibly also sleep-related neuroplastic changes.

Chairs M. Hatzinger (Solothurn, CH)

12:30 - 12:45 O110 Does restless REM sleep ruin resilience and recovery across mental disorders? E. Van Someren (Amsterdam, NL)

12:45 - 13:00 O111 Rapid eye movement sleep derived biomarkers of depression T. Mikoteit (Solothurn, CH)

13:00 - 13:15 O112 Disrupted sleep and psychopathology in schizophrenia A. Wichniak (Warsaw, PL)

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13:15 - 13:30 O113 The effect of psilocybin on sleep D. Urbaczka Dudysová (Klecany, CZ)

Animal Basic, Symposium, Stream 3 12:30 - 13:30 Sleep, ageing and neurodegeneration: from molecular insights to new treatments

Insufficient sleep has been linked to a broad range of neurological disorders, most notably Alzheimer’s disease, which is the most common form of dementia with no existing cure. Evidence points to an involvement of neurodegeneration, which is caused by abnormal protein homeostasis in the brain. Therefore, experimental approaches to enhance sleep represent a powerful but largely unexplored strategy for prevention of neurological disorders. This integrative symposium brings together experts in a wide range of experimental models and species, including flies, mice and humans and will provide an update of recent discoveries on the role of sleep in protein homeostasis and neurological disorders. The talks will cover a range of experimental approaches and techniques, including molecular genetics, brain imaging, electrophysiology, pharmacology and non-invasive tools for sleep enhancement. Vladyslav Vyazovskiy will introduce local and global aspects of sleep regulation and will discuss how local changes in spiking and synaptic activity can influence the local need for recovery provided by sleep. Jini Naidoo will present results on the link between the endoplasmic reticulum stress and sleep obtained in flies and mice. Marc Busche will present his work on the links between sleep and Alzheimer’s disease using a variety of in vitro and in vivo approaches including one- and multiphoton microscopy, electrophysiology, optogenetics and wide-field network imaging in combination with molecular and cell biological techniques. Finally, Lucia Talamini will discuss approaches for sleep enhancement as a novel therapeutic strategy for prevention and treatment of neurodegenerative diseases.

Chairs V. Vyazovskiy (Oxford, UK)

12:30 - 12:45 O114 Local and global aspects of sleep regulation: from single cell rest to network homeostasis V. Vyazovskiy (Oxford, UK)

12:45 - 13:00 O115 Sleep, aging, and cellular health: aged-related changes in sleep and protein homeostasis N. Naidoo (Philadelphia, US)

13:00 - 13:15 O116 Impaired sleep slow-wave oscillations in Alzheimer's Disease M. Busche (London, UK)

13:15 - 13:30 Sleep enhancement as a new treatment for neurodegenerative disorders L. Talamini (Amsterdam, NL)

Poster Session, Poster, Poster Networking Lounge 12:30 - 13:30 Poster Networking Lounge - open to visit

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P481 Interrelationships between sleepiness and the other obstructive sleep apnea symptoms K. Baou (Athens, GR)

P482 Evaluation of apap parameters in one to three nights titration for final pressure decision-making in a real world clinical setting J. Escribá Alepuz (Sagunto, Valencia, ES)

P483 Obstructive sleep apnea syndrome - diagnostic clues and hospital referral M. Baptista (Covilhã, PT)

P484 Diagnosis and treatment of obstructive sleep apnea syndrome in patients with heart failure M. Baptista (Covilhã, PT)

P485 Anthropometric measures: helping risk stratification for obstructive sleep apnea J. Costa (Guarda, PT)

P486 Psychopathological comorbidity of adult sleepwalking S. Delis Gómez (Madrid, ES)

P487 Trauma-associated sleep disorder - a distinct sleep disorder? S. Williams (Edinburgh, UK)

P488 REM sleep behavior disorder in patients with idiopathic hyposmia P. Marrero (Barcelona, ES)

P489 Morbidity in patients with NREM parasomnias in the Danish population N. Suhak (Copenhagen, DK)

P490 Respiratory effort assessment across clinical clusters in pediatric sleep disordered breathing J. Martinot (Namur, BE)

P491 Sleep disorders in night workers: effect of the shiftwork rotation scheme R.M. Lecca (Cagliari, IT)

P492 Clinical data in groups with elderly obstructive sleep apnea hypopnea syndrome and cognitive impairment A. Buigues Lafuente (Valencia, Valencia, ES)

P493 REM sleep behavior disorder and other sleep disturbances in Alzheimer's disease, dementia with Lewy bodies and in dementia cases of uncertain classification I. Pieroni (Florence, IT)

P494 Diurnal skin temperature variations and rest-wake activity patterns after acute ischemic stroke E. Pajediene (Kaunas, -, LT)

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P495 Sleep and episodic memory in alcohol use disorder with and without Korsakoff syndrome G. Rauchs (Caen, FR)

P496 Morbidity, mortality and conversion to neurodegenerative disorders in patients with RBD in the Danish population C. Asah (Glostrup, DK)

P497 Effects of temporal lobe epilepsy surgery on sleep macrostructure and microstructure A. Romigi (Pozzilli, IS, IT)

P498 Influence of chronic radiofrequency electromagnetic fields exposure on cerebral oxygenation in preterm neonates: preliminary results D. Besset (Amiens, FR)

P499 Sleep habits among a sample of preschool children with psychiatric diagnoses J. Mauricio (Viana do Castelo, PT)

P500 Sleep habits among adolescents in southern Greece M. Fountoulaki (Heraklion, GR)

Poster Session, Poster, Poster Networking Lounge 13:30 - 14:30 Poster Networking Lounge - open to visit

P501 Prevalence of cancer in Greek obstructive sleep apnea patients K. Baou (Athens, GR)

P502 Nocturnal blood pressure fluctuations in obstructive sleep apnea M.J. Pablo Zaro (Huesca, ES)

P503 Secreening and awareness of obstructive sleep apnea: from bench to society B. Santos (Coimbra, PT)

P504 Sleep and sleep disorders in a sample of 200 older adults E. Martin Abad (Madrid, ES)

P505 Differences between two groups of patients with sleep apnea: with and without cardiovascular comorbidity M. Blanco Beltran (Madrid, Select, ES)

P506 Sleep - a family topic? Parenting style, parenting sleep and sleep disturbances of their children A.A. Schlarb (Bielefeld, DE)

P507 Prevalence of anxiety and depressive symptoms among a sample of obstructive sleep apnoea non treated patients J. Mauricio (Viana do Castelo, PT)

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P508 A systematic review of objective sleep problems in persistent tic disorders and attention-deficit hyperactivity disorder L. Keenan (Dublin, IE)

P509 Italian Multicenter study on circadian and sleep alterations measured by activity trackers as markers of mild cognitive impairment and Alzheimer's disease: focus on sex differences M. Maestri (Pisa, IT)

P510 Female monozigotic twins affected with Kleine-Levin syndrome R. Peraita-Adrados (Madrid, ES)

P511 Comparison of Modafinil and Pitolisant in Narcoleps: a non inferiority meta-analytical approach C. Caussé (Paris, FR)

P512 Pupillary reactivity to blue light as a biomarker of depression in patients with idiopathic hypersomnia H. Rach (Strasbourg, FR)

P513 Intellectual efficiency of children with narcolepsy-cataplexy M. Thieux (Lyon, FR)

P514 NARCOCAST: study of prevalence of narcolepsy in Castellón province (Spain) R. Grande González (Castellón de la Plana, ES)

P515 The definition of insomnia in people with intellectual disabilaties: an overview N. van den Broek (Heeze, NL)

P516 Does the protocol solve all the problems? How to address the individual needs of patients in the eight-week Cognitive Behavioural Therapy of Insomnia programme A. Wichniak (Warsaw, PL)

P517 Changes of objective and subjective sleep discrepancy during and after the cognitive behavioural therapy for insomnia K. Janků (Klecany, CZ)

P518 Feasibility of a personalized and contextual mobile intervention for Insomnia M. Cohen-Zion (Tel Aviv-Jaffa, IL)

P519 The efficacy of Cognitive-Behavioral Therapy for Insomnia (CBT-I) is not predicted by objective sleep duration L. Ferini-Strambi (Milan, IT)

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Respiratory, Symposium, Stream 1 13:45 - 14:45 From pathophysiology to targeted treatment of OSA: CPAP and new emerging modalities?

Obstructive sleep apnea is a common sleep disorder with heterogeneity in clinical presentation and pathophysiology. Recently, four contributing phenotypes have been identified and included airway collapsibility, impaired pharyngeal dilator muscle function, lowered arousal threshold and loop gain. The understanding of pathophysiology and phenotyping the trait can enable a targeted treatment. The CPAP dial ups and downs has been established as a physiological standard procedure to identify the phenotypes. Breath holding as a means to estimate loop gain, upper airway collapsibility assessed by negative expiratory pressure while awake were reported. Automated signal processing algorithms on PSG data can calculate ventilatory drive, loop gain and arousal threshold. The mean inspiratory flow during flow limitations represents the surrogate of active Pcrit. Airflow shapes were analyzed to quantify the pharyngeal obstruction. Tagged MRI of tongue identify the bidirectional tongue movements for myofunctional therapy. High airway collapsibility and high loop gain were reported as predictors for failure of mandibular advancement devises and surgery. New pharmacotherapy seems to allow for new options for non-anatomical phenotypes. Surgery was employed in presence phasic non-positional desaturating moderate upper airways obstructive events. An awake and under sedation endoscopic identifies anatomic factors, representing a site of obstruction to select an appropriate surgical technique. The aim of this symposium is to discuss the integrative understanding of clinical presentation and the underlying complex pathophysiology. This may guide to individualized selection of single or combined therapeutical options, not only to achieve AHI below 10/h but also to improve quality of life.

Chairs V. Koka (Paris, FR)

13:45 - 14:00 O117 The multifaceted picture of OSA: can pathophysiological, polysomnographic or clinical characteristics guide treatment? W. Randerath (Solingen, DE)

14:00 - 14:15 O118 Insides from evolving phenotyping tools: emerging targeted nonCPAP therapies V. Koka (Paris, FR)

14:15 - 14:30 O119 Rationale for CPAP treatment, predictors of adherence and evaluation criteria of success J. Vaz de Castro (Lisboa, PT)

14:30 - 14:45 O120 Reconsider the rationale for mandibular advancement splits and surgical therapy: individualized treatment from preselection to multimodal concepts A. De Vito (Forli, IT)

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Psychiatry, Symposium, Stream 2 13:45 - 14:45 Targeting sleep to improve mental health

Mental disorders are among the leading causes for reduced quality of life due to illness worldwide. The majority of patients with mental disorders suffer from insomnia symptoms, and insomnia is associated with adverse physical and mental health outcomes. Current guidelines identify cognitive behavioral therapy for insomnia (CBT-I) as the first-line treatment. However, CBT-I is not sufficiently utilized in clinical care of patients with mental disorders. Rather, insomnia remains often untreated or treated with hypnotics, which could have adverse effects and could lead to tolerance and dependence. The current symposium aims to further elucidate the potential of utilizing CBT-I to improve mental health. It brings together speakers from different backgrounds and at different career levels, who share the idea that further investigating, implementing and disseminating CBT-I will contribute to improving sleep and health in patients with mental disorders, which would be of high public health relevance. The symposium will provide an overview of past and current activities and stimulate future discussions in the field.

Chairs C. Nissen (Berne, CH)

13:45 - 14:00 O121 SLEEPexpert - a behavioral treatment program for insomnia in patients with acute psychiatric disorders E. Hertenstein (Berne, CH)

14:00 - 14:15 O122 Cognitive behavioural therapy for insomnia in patients with concomitant anxiety disorders M. Jansson-Fröjmark (Stockholm, SE)

14:15 - 14:30 Sequential cognitive behavioral therapy and medication therapies for optimal management of insomnia comorbid with psychiatric disorders C.M. Morin (Quebec, QC, CA)

14:30 - 14:45 A tailored stepped care approach using digital and therapist-lead CBT-I for patients with and without mental illness R. Manber (Stanford, US)

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Animal Basic, Symposium, Stream 3 13:45 - 14:45 Hypothalamic involvement in sleep/wake control

Despite implication of an important role for the posterior hypothalamus (PH) in sleep/wake control from the classic studies of von Economo, Hess and Nauta, most hypothalamic-related sleep research in the second half of the 20th century focused on the preoptic-anterior hypothalamus and basal forebrain. With the discovery of the histaminergic cell groups and the hypocretin/orexin (Hcrt) cells, the focus has shifted to the PH over the past couple of decades. The fact that the sleep/wake phenotype of PH-lesioned animals is distinct from that of histaminergic or Hcrt/orexin knockout animals strongly suggests the existence of other PH neuronal populations that contribute to sleep/wake control. In this symposium, Christelle Peyron will discuss the role of the histaminergic cell groups in sleep/wake control, the role of the H3 receptor in cortical arousal, and the utility of histaminergic therapeutics in narcolepsy. Akihiro Yamanaka will review the role of melanin-concentrating hormone (MCH) cells in sleep, particularly REM sleep, the implication of these cells in memory and forgetting, and functional interactions between the hypothalamus and medial septum. Lateral hypothalamic GABAergic (LHGABA) cells are crucial modulators of sleep-wake states and consummatory behaviors. Carolina Gutierrez Herrera will discuss the multitasking function of these circuitries that provides insight into the integration of sleep and brain metabolism. Thomas Kilduff will describe a novel wake-promoting PH neuronal population that works synergistically with the Hcrt system to maintain wakefulness. Together, these presentations will update cutting-edge research on the PH and sleep/wake control recently published in Science, Nature Neuroscience and other leading journals.

Chairs C. Peyron (Lyon, FR)

13:45 - 14:05 Histamine and narcolepsy C. Peyron (Lyon, FR)

14:05 - 14:25 O123 The role of melanin concentrating hormone-producing neurons in the regulation of sleep and memory A. Yamanaka (Nagoya, JP)

14:25 - 14:45 Lateral hypothalamic inhibition of distinct circuits: a link between sleep and consummatory behaviours C. Gutierrez Herrera (Bern, CH)

Poster Session, Poster, Poster Networking Lounge 14:30 - 15:30 Poster Networking Lounge - open to visit

P521 Effects of miofunctional therapy (App AirwayGym (R) ) in the patient with sleep apnea hypopnea syndrome and simple snoring L. Rodríguez-Alcalá (Granada, ES)

P523 Acromegaly: a rare factor in (so common) Obstructive Sleep Apnea Syndrome A.P. Craveiro (Covilha, PT)

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P524 Evaluate the prevalence and specificity of sleep disorders in children aged 2-18 years with type 1 diabetes referred to endocrinology clinic in Iran 2018-2019 S. Jalilolghadr (Qazvin, IR)

P525 Sleep quality in health workers exposed to the COVID-19 pandemic A. Herrero San Martin (Madrid, Madrid, ES)

P527 Cognitive behavioural therapy for insomnia (CBT-I) conducted by video call communication during home confinement due to the COVID-19 outbreak J. Adrien (Paris, FR)

P528 Acceptance, feasibility and effectiveness of a sleep training for patients of a psychosomatic rehabilitation clinic - a randomized controlled study J. Faber (Bielefeld, DE)

P529 Molecular study of restless legs syndrome in Iranian families Z. Alibabaei (Tehran, Tehran, IR)

P530 Review and meta-analysis of pharmacological responsiveness of periodic limb movements during sleep S. Riccardi (Lugano, CH)

P531 The complex relation between sleep and motor performance in Parkinson's disease P.-L. Ratti (Venice, IT)

P532 Changes in midbrain iron deposits in restless legs syndrome after intravenous iron. Long-term neuroimaging and clinical follow-up C. Garcia Malo (Madrid, ES)

P533 Correlation of restless legs syndrome with oxygen saturation: implications for altitude S. Khachatryan (Yerevan, AM)

P534 Prevalence of risk factors in non-rapid eyes movement parasomnias in adults M. Pintor (Mostoles, Madrid, ES)

P535 Hyposmia in patients with isolated REM sleep behaviour disorder P. Marrero (Barcelona, ES)

P536 Validation of the Chinese version of the Munich Chronotype Questionnaire in Hong Kong youths F.T.W. Cheung (Hong Kong, HK)

P537 Actigraphy in brain-injured patients - a valid measurement for the assessment of circadian rhythms? M. Angerer (Salzburg, AT)

P538 Investigating the impact of sleep on declarative memory consolidation performance in children with self-limited focal epilepsy M. Brichet (Brussels, BE)

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P539 Effects of eslicarbazepine as add-on therapy on sleep architecture in temporal lobe epilepsy A. Romigi (Pozzilli, IS, IT)

P540 Continuous positive airway pressure prescription in pediatric obstructive sleep apnea during Covid 19 pandemic C. Pía (Vitoria-Gasteiz, ES)

Respiratory, Symposium, Stream 1 15:00 - 16:00 Something new under the sun: metabolic dysfunction in OSA

The growing number of patients with obstructive sleep apnea (OSA) is challenging health care systems worldwide. OSA is characterized by chronic intermittent hypoxemia and episodes of apnea and hypopnea. Cardiovascular and metabolic diseases are common in OSA, also in lean patients. Cognitive impairment increases the risk for moto-vehicle accidents. Further, comorbidity burden is not unambiguously linked to the severity of OSA. Interaction of fragmented sleep, chronic intermittent hypoxia and metabolism has not been fully elucidated. Gut dysbiosis seems to be an important factor in the pathophysiology of OSA- induced hypertension. OSA may alter cerebral metabolism and thereby predispose to neurocognitive impairment. Carotid body is a multi-sensor organ not sensoring only hypoxia and hypercapnia but also insulin resistance and glucose metabolism. OSA independently predicts lipid levels. This symposium will provide novel insights into the mechanisms of metabolic dysfunction in OSA combining recent evidence from basic, translational and clinical research, and paving way to new treatment options and precision medicine for OSA.

Chairs T. Saaresranta (Turku, FI) I. Almendros (Barcelona, ES)

15:00 - 15:15 O124 Microbiome and OSA I. Almendros (Barcelona, ES)

15:15 - 15:30 O125 Cerebral metabolism and OSA C. Liguori (Rome, IT)

15:30 - 15:45 O126 Carotid body, intermittent hypoxia and metabolism J.F. Sacramento (Lisbon, PT)

15:45 - 16:00 O127 Hyperlipidaemia and OSA O. Basoglu (Izmir, TR)

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Pediatric Medical Disorders, Symposium, Stream 2 15:00 - 16:00 A sensitive system under fire? Identifying sleep-wake- regulatory risk factors for the development of mental disorders during adolescence

Teenagers increasingly expose themselves to light and caffeine, powerful modulators of circadian rhythms and sleep-pressure. However, it remained unclear until recently to what extent the developing sleep-wake regulation reacts to this exposure. This is of importance as sleep-wake disturbances might make teenagers particularly vulnerable to the development of mental disorders. The first speaker, Stephanie Crowley, will focus on developmental aspects of photosensitivity in both animals and humans. Her recent studies suggest that the circadian response to light decreases across adolescence and is reduced under conditions of sleep restriction. In the second talk, Carolin Reichert will compare recent findings on caffeine effects in adolescent animals and present the first study on consequences of caffeine in human teenagers, suggesting that the stimulant strongly disrupts both sleep and the developing circadian timing system. Brant Hasler as the third speaker will review recent evidence that such circadian disturbances may make teenagers particular vulnerable to developing mental disorders by altering reward sensitivity and impairing impulse control. He will also present a new and promising circadian/sleep intervention to improve measures of reward sensitivity and impulsivity in teenagers. The fourth presentation, given by Leila Tarokh, will be dedicated to new insights about inter-individual differences in the sleep EEG of adolescents which might represent a useful tool to identify individuals at risk to develop a mental disorder. The presentations will bring together new insights on mechanisms and consequences of changes in the adolescent sleep-wake-regulation, and also discuss promising strategies to prevent early onset of mental disorders.

Chairs C. Reichert (Basel, CH) L. Tarokh (Berne, CH)

15:00 - 15:12 O128 Circadian light sensitivity of adolescents S.J. Crowley (Chicago, US)

15:12 - 15:14 Q&A

15:14 - 15:26 O129 Caffeine effects on sleep-wake regulation during adolescence C. Reichert (Basel, CH)

15:26 - 15:28 Q&A

15:28 - 15:40 O130 Sleep and circadian effects on reward sensitivity and impulse control during adolescence B. Hasler (Pittsburgh, US)

15:40 - 15:42 Q&A

15:42 - 15:54 O131 Inter-individual differences in sleep: implications for adolescent mental health L. Tarokh (Berne, CH)

15:54 - 15:56 Q&A

15:56 - 16:00 General Discussion

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Animal Basic, Symposium, Stream 3 15:00 - 16:00 Phosphorylation hypothesis of sleep

Sleep is an evolutionarily conserved off-line status of the animals with unknown function and molecular and cellular mechanisms. Recently, the researchers discovered the sleep-promoting kinases, CaMKIIIα/β, SIK3 and ERK1/2 using reverse genetics, forward genetics and in-vitro-slice-based screening of pharmacologically active compounds for sleep. Interestingly, these kinases can respond to neural activity, energy and metabolic stress, and other survival cellular stresses and convey and stimulate the downstream reactions to cope with the disturbance of the homeostasis. Furthermore, quantitative and comprehensive proteomics and phospho-proteomics of the brain and synapses have revealed the homeostatic and circadian control of sleep can be represented as protein phosphorylation. Importantly, phosphorylation and de-phosphorylation (or alternatively degradation and synthesis) of proteins may underlie in the core of the sleep regulations. Based on these recent findings, we here propose that “phosphorylation hypothesis of sleep” where sleep need of brain or even a neuron itself can be represented as a phosphorylation status of a set of proteins mediated by sleep-promoting kinases. In this review, we discuss how sleep-promoting kinase can sense the internal state changes such as neural activity, energy and metabolic changes, cellular damages and stresses to convert them into sleep needs. We also discuss how phosphorylation hypothesis of sleep and its implication in psychiatric and neurodegenerative disorders have been successfully integrated to create new biological insights and provide a perspective for future opportunities in neuroscience.

Chairs H. Ueda (Tokyo, JP)

15:00 - 15:15 Why phosphorylation matters M. Tafti (Lausanne, CH)

15:15 - 15:30 O132 Phosphorylation hypothesis of sleep H. Ueda (Tokyo, JP)

15:30 - 15:45 Molecular substrates of homeostatic sleep regulation Q. Liu (Dallas, US)

15:45 - 16:00 Biphasic phosphorylations for sleep and wake S. Bernardez (Zurich, CH)

Poster Session, Poster, Poster Networking Lounge 15:30 - 16:30 Poster Networking Lounge - open to visit

P541 Perception of infant sleep problems: associations with infant temperament and maternal mood R. Burdayron (Montreal, QC, CA)

P542 Poor sleep after mild traumatic brain injury is associated with increased inflammation in warfighters J. Pucci (Bethesda, MD, US)

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P543 Diffusion tensor magnetic resonance imaging of hypothalamus in traumatic brain injury warfighters with sleep dysfunction J.K. Werner (Bethesda, MD, US)

P544 Association between sleep and behaviour in school in gifted children with or without a neurodevelopmental disorder L. Bastien (Montreal, QC, CA)

P545 Poor sleep quality predicts plasma markers of neurodegeneration and cognitive deficits in warriors with mild traumatic brain injury J.K. Werner (Bethesda, MD, US)

P546 Sleep and emotional state after concomitant traumatic brain and spinal cord injuries M. Regniez (Montréal, QC, CA)

P547 Variability in natural history, polysomnographic and polygraphic findings in residual pediatric obstructive sleep apnea: an interim analysis of recruitment candidates for ERMES randomized clinical trial M. Fernández-Barriales (Vitoria-Gasteiz, ES)

P548 Online adaptation of a child-parent sleep training for 5-10 years olds - acceptance and first results A.A. Schlarb (Bielefeld, DE)

P549 The relationship between sleep continuity, tobacco smoking and cortisol secretion among young adults A. Cohen (Emek Yezreel, IL)

P550 Does sleep mediate the association between PTSD symptoms and pain in trauma-affected refugees? J. Friis (Ballerup, DK)

P551 Psychiatric characteristics and sleep quality among people living with HIV S. Akbarpour (Tehran, IR)

P552 A case series of non-24-hour-Sleep Wake Disorder (N24SWD) in sighted patients K.J. van Rijn (Zwolle, NL)

P553 Prevalence of Circadian Rhythm Sleep - Wake Disorders in Cyprus F. Frangopoulos (Strovolos, Nicosia, CY)

P554 Long-term outcome of a series of patients with narcolepsy type 1 and comorbidity with immunopathological and autoimmune diseases F.J. Martínez-Orozco (Madrid, Madrid, ES)

P555 Clinical experience of Pitolisant in Sweden H. Gretarsdottir (Uppsala, SE)

P556 The Narcolepsy Monitor: an app to gain insight in narcolepsy symptom burden L. Quaedackers (Heeze, NL)

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P557 Is verbal memory impaired in Narcolepsy type I? A preliminary neuropsychological study P. Medrano-Martínez (Alcalá de Henares, ES)

P558 Narcolepsy following the H1N1-pandemia/vaccinations in Norway - 10 year update S. Knudsen-Heier (Oslo, NO)

P559 Treating and preventing depression by addressing insomnia - long-term follow-up of three RCTs K. Blom (Stockholm, SE)

P560 The efficacy of cognitive behavioral therapy for insomnia (CBT-I) in a sample of Egyptian patients N. Hani (Cairo, EG)

Keynote, Keynote Lecture, Stream 1 16:30 - 17:15 Keynote Lecture - D. Gozal, US

Chairs W. McNicholas (Dublin, IE)

16:30 - 17:15 O133 Circulating exosomes and morbidity of obstructive sleep apnea: effectors, biomarkers, both? D. Gozal (US)

Poster Session, Poster, Poster Networking Lounge 16:30 - 17:30 Poster Networking Lounge - open to visit

P561 Use of an adjustable bed base to sleep in an inclined position shows significantly reduced objective snoring and improved sleep: an in-home product effectiveness study S. Danoff-Burg (Carlsbad, CA, US)

P562 Correlation between severity of insomnia, sleep quality and parameters obtained from sleep calendar, actigraphy and polysomnography in patients with chronic insomnia B. Cocho (Pamplona, Navarra, ES)

P563 Adherence behaviour in cognitive behavioural therapy for insomnia: findings from a randomised control trial L. Steinmetz (Freiburg, DE)

P565 PE2-I PET of RBD, initial findings R. Frandsen (Glostrup, DK)

P567 Mood disorders symptoms in REM and NREM parasomnias M. Ntafouli (Athens, GR)

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Thursday, 24 September 2020

P568 From pillow to soccer field, a real world evaluation of sleep in elite players M. Barata (Almada, PT)

P569 NREM parasomnias in the medical residency period M.D. Calabria Gallego (Salamanca, Salamanca, ES)

P570 Do spike-waves during slow wave sleep affect sleep recovery in pediatric patients? First steps towards an automated analyses approach J. Skorucak (Zürich, CH)

P571 Supplemental oxygen improves respiratory stability in ex-early preterm infants, but not as well as non-invasive ventilation: a case study using polysomnography S. Scaillet (Brussels, BE)

P572 Distress and adjustment difficulty due to the covid-19 pandemic in israel: mediation effect of sleep quality O. Tzischinsky (Emek Yezreel, IL)

P573 Long-term follow-up on the effects of sodium oxibate on sleep architecture in patients with narcolepsy type 1 P. Medrano-Martínez (Alcalá de Henares, ES)

P574 Impact of insomnia and experimentally disrupted sleep on overnight memory consolidation X. Omlin (Oxford, UK)

P575 Sleep disorder patients during COVID19: preliminary results from a collaborative Portuguese network of Sleep Laboratories T. Paiva (Lisboa, PT)

P576 Quantitative actigraphic analysis in isolated REM sleep behavior disorder M. Filardi (Bologna, IT)

P577 Sleep related bruxism: beyond teeth wear! D. Neu (Brussels, BE)

P578 A study on the prevalence of sleep disorders in Scottish patients with multiple sclerosis: how common is obstructive sleep apnoea? R. Riha (Edinburgh, UK)

P580 Cross-cultural comparison of sleep patterns of typically developing children and children with autism spectrum disorder in the UK and South Korea M. Jeon (London, UK)

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Thursday, 24 September 2020

Keynote, Keynote Lecture, Stream 1 17:30 - 18:15 Keynote Lecture - L. de Lecea, US

Chairs P.-H. Luppi (Lyon, FR)

17:30 - 18:15 O134 Optogenetic control of arousal state transitions L. de Lecea (US)

Poster Session, Poster, Poster Networking Lounge 17:30 - 18:30 Poster Networking Lounge - open to visit

P581 Epworth Sleepiness Scale Test - retest reliability analysis in solriamfetol studies R. Rosenberg (Atlanta, GA, US)

P583 Effects of home confinement due to COVID_19 pandemic on sleep-wake patterns in young adults from Santiago, Chile C. Algarin (Santiago, RM, CL)

P584 Selective CPAP withdrawal with supplemental oxygen during slow wave sleep as a method of dissociating sleep fragmentation and intermittent hypoxia related sleep disruption in OSA A.E. Mullins (New York, NY, US)

P585 A psychological view on the effectiveness of psychosocial interventions on positive airway pressure treatment adherence and sleep quality in patients with obstructive sleep apnea M. Bertrand (Quebec, QC, CA)

P586 Emotion coping strategy and sleep-related beliefs and attitudes are associated with objective sleep problems in young insomnia patients O. Ballot (Quebec, QC, CA)

P587 The mediating role of arousal and hot flashes between the daily stress and sleep in menopausal women with and without insomnia O. Ballot (Quebec, QC, CA)

P588 Psychophysiological responses to an acute experimental stressor in adolescent boys and girls with and without insomnia M. de Zambotti (Menlo Park, CA, US)

P589 Sleep recovery from acute to chronic moderate-severe traumatic brain injury is associated with long-term functional cognitive outcomes E. Sanchez (Montréal, QC, CA)

P590 Circadian preference, social jetlag and socio-emotional functioning of gifted children L. Bastien (Montreal, QC, CA)

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Thursday, 24 September 2020

P591 Influence of Toddlers sleep on parental -sleep, -emotional competence, and -sleep related cognitions - Do differences between mothers and fathers exist? F. Lollies (Bielefeld, DE)

P592 Project of the trial of effectiveness and cost-effectiveness of internet- based cognitive behavioral therapy for insomnia P. Pchelina (Bern, CH)

P593 Sleep schedule and insomnia risk in computer technician students at Mare de Deu de la Mercè Institute in Barcelona B. Garcia Parra (L'Hospitalet de Llobregat. Barcelona, Barcelona, ES)

P595 Association of REM sleep with body fat distribution in patients with insomnia disorder R. Göder (Kiel, DE)

P596 Sleep after concussion: long-term monitoring in children and adolescents in a home-setting J. Albrecht (Zurich, CH)

P597 Examining the efficacy of pharmacological interventions for sleep and circadian rhythm disturbance in bipolar disorder: a systematic review L. Bisdounis (Oxford, UK)

P598 Association between sleep duration and refractive errors: a cohort study on French preschoolers S. Plancoulaine (Villejuif, FR)

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Thursday, 24 September 2020

Respiratory, Symposium, Stream 1 18:30 - 19:30 Does CPAP reduce cardiovascular risk in patients with OSA? Where do we go from here?

Epidemiological evidence studies suggest obstructive sleep apnea is an independent risk factor for cardiovascular disease and events. However, recent large randomized trials (SAVE; McEvoy RD, NEJM 375:919, 2016) have been negative. There are various explanations for this including low adherence to CPAP and exclusion of individuals who are not at risk for the CV consequences. There are different clinical subtypes of OSA. It is only the excessively sleepy group that have increased CV risk (Mazzotti DR, AJRCCM 200:493, 2019). These were excluded in the SAVE study due to ethical concerns about randomizing sleepy patients. We will describe the current status of knowledge and describe a potential way forward. The symposium will begin with an overview by Dr. Javaheri of what we have learned from the SAVE study (see Chest 156:431, 2019). This will be followed by a presentation by Greg Maislin on “Use of Propensity Score Matching”. This allows inclusion of sleepy patients with OSA. It allows an observational design that approximates a randomized trial thereby allowing causal inference. Dr. Bhajan Sing from Perth, Australia, will then describe how this approach can be used to address the question as to whether CPAP treatment reduces CV events. Dr. Allan Pack will describe additional questions that need to be addressed. Specifically, he will describe new approaches to enhancing CPAP adherence and the concept of “unprotected sleep”. There will be a final discussion panel to allow individuals in the audience to give their opinions and address questions to the panel on this topic.

Chairs A. Pack (Philadelphia, US)

18:30 - 18:35 Overview of issues in randomized control trials of cardiovascular outcomes with CPAP

18:35 - 18:50 Developing new approaches to randomized trials of CPAP S. Javaheri (Cincinnati, US)

18:50 - 19:05 What is propensity score matching? G. Maislin (Philadelphia, US)

19:05 - 19:20 Applying propensity score matching to study effects of CPAP on cardiovascular events B. Singh (Perth, AU)

19:20 - 19:30 Final Q & A A. Pack (Philadelphia, US)

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Thursday, 24 September 2020

Pediatric Medical Disorders, Symposium, Stream 2 18:30 - 19:30 Hiding in plain sight: sleep, neurodevelopment, and pediatric mental health

This symposium characterizes the associations of sleep, neurodevelopment and child and adolescent mental health. Sleep problems are under-appreciated mechanisms underlying developmental psychopathology and healthy brain development. In this symposium we will discuss latest science on sleep and mental health in children from a top down approach. First, [Koopman-Verhoeff] we discuss the epidemiology of sleep and mental health in the general pediatric population, using a large sample with repeated measures of objective and subjective sleep problems and mental health to tease apart how sleep behavior and child psychopathology relate at the highest level. Next we will turn to three distinct areas of child psychopathology and discuss the mechanisms through which sleep contributes to each. (1) [Jones] we will demonstrate the power of circuit neuroscience and genetic models to link underlying neural changes to phenotypic EEG expression with human and mice models of 22q11.2 deletion syndrome as a key example relating sleep phenotypes to schizophrenia risk. (2) [Saletin] we will discuss whether attention-deficit/hyperactivity-disorder (ADHD) symptoms reflect sleep neurophysiology and the response of the developing brain to sleep loss. (3) [Soehner] will describe how age-associated deviations in brain structural maturation relate to actigraphic sleep and mood symptom profiles across adolescent development in a large neuroimaging cohort. In sum, this symposium combines complementary work across descriptive levels to describe an emerging translational science of sleep-dependent mental health in children. A final discussion will pose future research priorities and areas of opportunity for the field.

Chairs M.E. Koopman-Verhoeff (Rotterdam, NL)

18:30 - 18:45 O135 The epidemiology of sleep and pediatric psychopathology: findings from the generation R study M.E. Koopman-Verhoeff (Rotterdam, NL)

18:45 - 19:00 Non-REM neurophysiology and the circuitry of psychiatric risk - translational studies of genotyped healthy volunteers, patients and mouse models M. Jones (Bristol, UK)

19:00 - 19:15 O136 Sleep and the ADHD brain in children: dysregulated, vulnerable, inattentive J.M. Saletin (Providence, US)

19:15 - 19:30 O137 Age-associated variation in brain maturation: relationships with sleep and mood symptoms across adolescent development A.M. Soehner (Pittsburgh, US)

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Thursday, 24 September 2020

Animal Basic, Symposium, Stream 3 18:30 - 19:32 Sleep and plasticity: hypotheses and evidence

Behavioural studies in humans and animals show that sleep is critical for memory consolidation, but the underlying cellular and molecular mechanisms are poorly understood. Understanding the physiology of sleep-dependent memory consolidation is not only key to understand the cognitive deficits linked to sleep disorders but also how neuropathologies linked to impaired plasticity functions (e.g. neurodevelopmental and neurodegenerative disorders) may influence sleep. Converging evidence show that sleep and specific brain activity during sleep may contribute to changes in synaptic functions and plasticity, but which plasticity mechanisms are triggered during sleep is a matter of debate. In this symposium we will highlight different hypotheses linking sleep to plasticity and the evidence from rodent studies that support them. More specifically, Chiara Cirelli will discuss the Synaptic Homeostasis Hypothesis (SHY) and present evidence that sleep selectively downscales synapses using sleep manipulation (e.g. sleep deprivation) and modality-specific learning (i.e. motor learning) paradigms. Julie Seibt will discuss the complementary role of sleep stages (and oscillations in synaptic plasticity consolidation and provide evidence from molecular and calcium imaging. Sidarta Ribeiro will discuss the brain region specificity of plasticity mechanisms during sleep and show evidence from the hippocampus and cortex, two key brain regions involved in memory formation. Finally, Irene Navarro Lobato will discuss how manipulating plasticity in the prefrontal cortex can lead to changes is sleep characteristics and memory processes.

Chairs L. Genzel (Nijmegen, NL)

18:30 - 18:32 Introduction L. Genzel (Nijmegen, NL)

18:32 - 18:47 O138 Effects of motor learning, sleep, and sleep deprivation on cortical synapses C. Cirelli (Madison, US)

18:47 - 19:02 O139 Brain state-dependent cortical plasticity: the synaptic tagging and consolidation theory of sleep J. Seibt (Surrey, UK)

19:02 - 19:17 O140 Phosphoproteomics of experience-dependent changes during slow-wave sleep and REM sleep: differences between hippocampus and primary somatosensory cortex of rats S. Ribeiro (Natal, BR)

19:17 - 19:32 O141 An increase in cortical plasticity facilitates episodic memory and leads semantic interference effect possible due to REM sleep I. Navarro Lobato (Nijmegen, NL)

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Thursday, 24 September 2020

Respiratory, European Network Session, Stream 1 19:45 - 20:45 European Network Session: Sleep Apnea

Chairs J. Verbraecken (Antwerp, BE) M. van Zeller (Oporto, PT)

19:45 - 20:00 Sleep apnea management in Europe – an update 10 years ahead N. Laharnar (DE)

20:00 - 20:15 Cluster analysis of OSA phenotypes in the ESADA cohort S. Bailly (Grenoble, FR)

20:15 - 20:30 Use of the novel “Baveno classification” in a large European patient sample – clinical validity W. Randerath (Solingen, DE)

20:30 - 20:45 COVID-19 related shut down and proposed reopening of sleep apnea services in Europe M. Bonsignore (Palermo, IT)

Psychiatry, Case Discussion, Stream 2 19:45 - 20:45 Case discussion: Managing insomnia in psychiatry and psychotherapy

The case discussion session aims to complement other scientific sessions by discussing adaptations of evidence-based treatment components for insomnia to the needs of patients with severe mental disorders. This is relevant because mental disorders are among the leading causes for reduced quality of life due to illness worldwide, the majority of patients with mental disorders suffer from insomnia, and insomnia is associated with adverse health outcomes. The symposium is suited to inform clinical treatment adaptations and to identify fields of future investigations.

Chairs C. Nissen (Berne, CH)

19:45 - 20:05 Treating insomnia and hypersomnia in a patient with depressive disorder: a case formulation approach R. Manber (Stanford, US)

20:05 - 20:25 Adapting CBT-I to the needs of a patient with insomnia and depression A. Johann (Freiburg, DE)

20:25 - 20:45 Beyond the manual: implementing a pragmatic behavioral treatment program for insomnia in a patient with acute psychosis C. Nissen (Berne, CH)

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Thursday, 24 September 2020

Pediatric Medical Disorders, European Network Session, Stream 3 19:45 - 20:45 European Network Session: Narcolepsy

Chairs C. Bassetti (Berne, CH) G. Plazzi (Bologna, IT)

19:45 - 19:55 EU-NN Database: Unbiased Machine Learning J. Gool (Amsterdam, NL)

19:55 - 20:05 Narcolepsy Incidence Peak in 2013 Z. Zhang (Barmelweid, CH)

20:05 - 20:15 EU-NN Brain Bank R. Fronczek (Leiden, NL)

20:15 - 20:25 Histamine and Narcolepsy L. Shan (Leiden, NL)

20:25 - 20:35 EAN/ESRS/EU-NN Narcolepsy Guidelines U. Kallweit (Witten, DE)

20:35 - 20:45 EUNN 2020: an update C. Bassetti (Berne, CH)

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