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ON ATTRACTION of SLIME MOULD PHYSARUM POLYCEPHALUM to PLANTS with SEDATIVE PROPERTIES 1. Introduction Physarum Polycephalum Belo
ON ATTRACTION OF SLIME MOULD PHYSARUM POLYCEPHALUM TO PLANTS WITH SEDATIVE PROPERTIES ANDREW ADAMATZKY Abstract. A plasmodium of acellular slime mould Physarum polycephalum is a large single cell with many nuclei. Presented to a configuration of attracting and repelling stimuli a plasmodium optimizes its growth pattern and spans the attractants, while avoiding repellents, with efficient network of protoplasmic tubes. Such behaviour is interpreted as computation and the plasmodium as an amorphous growing biologi- cal computer. Till recently laboratory prototypes of slime mould computing devices (Physarum machines) employed rolled oats and oat powder to represent input data. We explore alternative sources of chemo-attractants, which do not require a sophis- ticated laboratory synthesis. We show that plasmodium of P. polycephalum prefers sedative herbal tablets and dried plants to oat flakes and honey. In laboratory experi- ments we develop a hierarchy of slime-moulds chemo-tactic preferences. We show that Valerian root (Valeriana officinalis) is strongest chemo-attractant of P. polycephalum outperforming not only most common plants with sedative activities but also some herbal tablets. Keywords: Physarum polycephalum, slime mould, valerian, passion flower, hops, ver- vain, gentian, wild lettuce, chemo-attraction 1. Introduction Physarum polycephalum belongs to the species of order Physarales, subclass Myxo- gastromycetidae, class Myxomycetes, division Myxostelida. It is commonly known as a true, acellular or multi-headed slime mould. Plasmodium is a `vegetative' phase, single cell with a myriad of diploid nuclei. The plasmodium looks like an amorphous yellowish mass with networks of protoplasmic tubes. The plasmodium behaves and moves as a giant amoeba. It feeds on bacteria, spores and other microbial creatures and micro- particles (Stephenson & Stempen, 2000). -
Average Weight of Common Household Furniture
AVERAGE WEIGHT OF COMMON HOUSEHOLD FURNITURE Average Weight Average Weight FURNITURE TYPE (EMPTY) FURNITURE TYPE (EMPTY) Armoire (Large) 200 Bed Headboard (Full) 40 Armoire (Medium) 150 Bed Headboard (King) 55 Armoire (Small) 100 Bed Headboard (Queen) 45 Baby Changing Table 50 Bed Headboard (Twin) 20 Baby Crib (Frame) 40 Bed Rails 10 Baby Crib (Mattress) 15 Bench (Wooden) 75 Baby High Chair 30 Bicycle 25 Baby Play Pen 60 Book Case (Large) 100 Baby Stroller 25 Book Case (Medium) 75 Bar 175 Book Case (Small) 25 Bar Stool 15 Boxes 40 Bed - Double (Box Spring) 60 Boxspring (Full Size) 60 Bed - Double (Footboard) 25 Boxspring (Queen Size) 75 Bed - Double (Headboard) 40 Boxspring (Twin Size) 50 Bed - Double (Mattress/Pillow Top) 75 Breakfront 200 Bed - Double (Mattress/Standard) 60 Buffet 125 Bed - Double (Set of Rails) 10 Cabinet (Curio) 150 Bed - Queen Size (Boxspring) 75 Cabinet (w/ Glass) 100 Bed - Queen Size (Footboard) 35 Cabinet (Wooden) 125 Bed - Queen Size (Headboard) 45 Carpet (Rolled) 125 Bed - Queen Size (Mattress/Pillow Top) 100 Chair ( Recliner) 125 Bed - Queen Size (Mattress/Standard) 75 Chair (Desk) 35 Bed - Queen Size (Set Rails) 10 Chair (Dining/Arms) 20 Bed - Twin Size (Boxspring) 50 Chair (Dining/No Arms) 15 Bed - Twin Size (Footboard) 15 Chair (Glider) 85 Bed - Twin Size (Headboard) 20 Chair (Occasional) 75 Bed - Twin Size (Mattress/Pillow Top) 75 Chair (Open Arm) 15 Bed - Twin Size (Mattress/Standard) 50 Chair (Overstuffed) 85 Bed - Twin Size (Set of Rails) 10 Chair (Papasan) 50 Bed Footboard (Full) 25 Chair (Rocker) 20 Bed Footboard (King) 45 Chair (Straight Back) 35 Bed Footboard (Queen) 35 Chair (Wing) 75 Bed Footboard (Twin) 15 Chaise Lounge 100 Bed Frame (Metal) 25 Chest 75 CONTINUED . -
Yerevan State Medical University After M. Heratsi
YEREVAN STATE MEDICAL UNIVERSITY AFTER M. HERATSI DEPARTMENT OF PHARMACY Balasanyan M.G. Zhamharyan A.G. Afrikyan Sh. G. Khachaturyan M.S. Manjikyan A.P. MEDICINAL CHEMISTRY HANDOUT for the 3-rd-year pharmacy students (part 2) YEREVAN 2017 Analgesic Agents Agents that decrease pain are referred to as analgesics or as analgesics. Pain relieving agents are also called antinociceptives. An analgesic may be defined as a drug bringing about insensibility to pain without loss of consciousness. Pain has been classified into the following types: physiological, inflammatory, and neuropathic. Clearly, these all require different approaches to pain management. The three major classes of drugs used to manage pain are opioids, nonsteroidal anti-inflammatory agents, and non opioids with the central analgetic activity. Narcotic analgetics The prototype of opioids is Morphine. Morphine is obtained from opium, which is the partly dried latex from incised unripe capsules of Papaver somniferum. The opium contains a complex mixture of over 20 alkaloids. Two basic types of structures are recognized among the opium alkaloids, the phenanthrene (morphine) type and the benzylisoquinoline (papaverine) type (see structures), of which morphine, codeine, noscapine (narcotine), and papaverine are therapeutically the most important. The principle alkaloid in the mixture, and the one responsible for analgesic activity, is morphine. Morphine is an extremely complex molecule. In view of establish the structure a complicated molecule was to degrade the: compound into simpler molecules that were already known and could be identified. For example, the degradation of morphine with strong base produced methylamine, which established that there was an N-CH3 fragment in the molecule. -
Choose the Perfect Sleeping Pillow for You 1 • Soft Support (All Down) • Medium Support (50/50 Feather and Down) • Convertible Support (Removable Insert)
Somnvie’s five TOUCH An unrivaled collection steps to a more of quality Sheet Sets, Pillow Cases, Shams and Duvet Covers. restful sleep. WARMTH Blankets and Comforters allow you to adjust your sleep temperature any time of the year. years of SUPPORT The right combination linens of Pillows layered expertise specifically to your 40 perfect sleep style. COMFORT Adjust your mattress The somnvie difference: with a Mattress Enhancer to create the perfect you work directly with foundation for restorative sleep. a brand associate to customize the bed of your PROTECT dreams—one tailored Mattress and Pillow Protectors keep exactly to your personal moisture, allergens and bugs away. tastes. The result is a healthier and more luxurious night’s sleep. Sleep better. Live better. Cool Simply White & Crisp Developed in Europe for Somnvie Cherry Blossom Pillow Cases And Shams using a luxurious percale weave and Extra Pillowcases and Pillow uniquely spun yarns, this collection Shams available. Buttery & Rain Cloud Soft, Cool & Crisp. Available in is for those who appreciate a fresh Standard, King, and Euro Square. sensation when sliding into bed. Sky Blue 200 Thread Count Duvet Cover Set Includes Duvet Cover and Simply White Pillow Shams. Buttery & Soft, Cool & Crisp. Available in Buttery Twin, Full / Queen and King. & Soft Sheet Set Uniquely crafted for Somnvie from Classic Cream Includes Fitted Sheet, Flat Sheet, ultra-fine yarns spun with American and set of Pillowcases. Available grown premium Supima Cotton, this in Twin, Twin XLong, Full, Queen, Sea Glass King and California King. collection is for those who enjoy an indulgently soft touch. -
Drugs Inducing Insomnia As an Adverse Effect
2 Drugs Inducing Insomnia as an Adverse Effect Ntambwe Malangu University of Limpopo, Medunsa Campus, School of Public Health, South Africa 1. Introduction Insomnia is a symptom, not a stand-alone disease. By definition, insomnia is "difficulty initiating or maintaining sleep, or both" or the perception of poor quality sleep (APA, 1994). As an adverse effect of medicines, it has been documented for several drugs. This chapter describes some drugs whose safety profile includes insomnia. In doing so, it discusses the mechanisms through which drug-induced insomnia occurs, the risk factors associated with its occurrence, and ends with some guidance on strategies to prevent and manage drug- induced insomnia. 2. How drugs induce insomnia There are several mechanisms involved in the induction of insomnia by drugs. Some drugs affects sleep negatively when being used, while others affect sleep and lead to insomnia when they are withdrawn. Drugs belonging to the first category include anticonvulsants, some antidepressants, steroids and central nervous stimulant drugs such amphetamine and caffeine. With regard to caffeine, the mechanism by which caffeine is able to promote wakefulness and insomnia has not been fully elucidated (Lieberman, 1992). However, it seems that, at the levels reached during normal consumption, caffeine exerts its action through antagonism of central adenosine receptors; thereby, it reduces physiologic sleepiness and enhances vigilance (Benington et al., 1993; Walsh et al., 1990; Rosenthal et al., 1991; Bonnet and Arand, 1994; Lorist et al., 1994). In contrast to caffeine, methamphetamine and methylphenidate produce wakefulness by increasing dopaminergic and noradrenergic neurotransmission (Gillman and Goodman, 1985). With regard to withdrawal, it may occur in 40% to 100% of patients treated chronically with benzodiazepines, and can persist for days or weeks following discontinuation. -
Somnvie Mattress Encasement and Protectors Help Protect You From
Somnvie’s five TOUCH An unrivaled collection steps to a more of quality Sheet Sets, Pillow Cases, Shams and Duvet Covers. restful sleep. WARMTH Blankets and Comforters allow you to adjust your sleep temperature any time of the year. years of SUPPORT The right combination linens of Pillows layered expertise specifically to your 40 perfect sleep style. COMFORT Adjust your mattress The somnvie difference: with a Mattress Enhancer to create the perfect you work directly with foundation for restorative sleep. a brand associate to customize the bed of your PROTECT dreams—one tailored Mattress and Pillow Protectors keep exactly to your personal moisture, allergens and bugs away. tastes. The result is a healthier and more luxurious night’s sleep. Sleep better. Live better. Cool Simply White & Crisp Developed in Europe for Somnvie Cherry Blossom Pillow Cases And Shams using a luxurious percale weave and Extra Pillowcases and Pillow uniquely spun yarns, this collection Shams available. Buttery & Rain Cloud Soft, Cool & Crisp. Available in is for those who appreciate a fresh Standard, King, and Euro Square. sensation when sliding into bed. Sky Blue 200 Thread Count Duvet Cover Set Includes Duvet Cover and Simply White Pillow Shams. Buttery & Soft, Cool & Crisp. Available in Buttery Twin, Full / Queen and King. & Soft Sheet Set Uniquely crafted for Somnvie from Classic Cream Includes Fitted Sheet, Flat Sheet, ultra-fine yarns spun with American and set of Pillowcases. Available grown premium Supima Cotton, this in Twin, Twin XLong, Full, Queen, Sea Glass King and California King. collection is for those who enjoy an indulgently soft touch. -
Sleep Inducing Toothpaste Made with Natural Herbs and a Natural Hormone
Sleep inducing toothpaste made with natural herbs and a natural hormone Abstract A toothpaste composition for inducing sleep while simultaneously promoting intraoral cleanliness, which includes toothpaste base ingredients and at least one sleep- inducing natural herb or hormone. The sleep-inducing natural herbs and hormone are selected from the group consisting of Chamomile, Lemon Balm, Passion Flower, and Valerian, and the hormone Melatonin. The sleep-inducing natural herbs are in a range of 0.25% to 18% by weight of the composition. Description of the Invention FIELD OF THE INVENTION The following natural herbs and natural hormone in combination with toothpaste is used at night to improve sleep. The expected dose of toothpaste is calculated at 2 grams. The ingredients have been assessed for range of daily dose for best effects, toxicity in normal range, recommended proportion of each, and water solubility of key constituents. BACKGROUND OF THE INVENTION It is an object of the present invention to provide a sleep-inducing toothpaste or mouth spray which includes sleep-inducing natural herbs and a natural hormone. It is a further object of the present invention to provide a sleep-inducing toothpaste which includes toothpaste base ingredients and natural herbs being Chamomile, Lemon Balm, Passion Flower, Valerian and the natural hormone Melatonin. SUMMARY OF THE INVENTION A toothpaste composition is provided for inducing sleep while simultaneously promoting intraoral cleanliness, which includes toothpaste base ingredients and at least one sleep-inducing natural herb or hormone. The sleep-inducing natural herbs and hormone are selected from the group consisting of the natural herbs Chamomile, Lemon Balm, Passion Flower, and Valerian, and the natural hormone Melatonin. -
THE USE of MIRTAZAPINE AS a HYPNOTIC O Uso Da Mirtazapina Como Hipnótico Francisca Magalhães Scoralicka, Einstein Francisco Camargosa, Otávio Toledo Nóbregaa
ARTIGO ESPECIAL THE USE OF MIRTAZAPINE AS A HYPNOTIC O uso da mirtazapina como hipnótico Francisca Magalhães Scoralicka, Einstein Francisco Camargosa, Otávio Toledo Nóbregaa Prescription of approved hypnotics for insomnia decreased by more than 50%, whereas of antidepressive agents outstripped that of hypnotics. However, there is little data on their efficacy to treat insomnia, and many of these medications may be associated with known side effects. Antidepressants are associated with various effects on sleep patterns, depending on the intrinsic pharmacological properties of the active agent, such as degree of inhibition of serotonin or noradrenaline reuptake, effects on 5-HT1A and 5-HT2 receptors, action(s) at alpha-adrenoceptors, and/or histamine H1 sites. Mirtazapine is a noradrenergic and specific serotonergic antidepressive agent that acts by antagonizing alpha-2 adrenergic receptors and blocking 5-HT2 and 5-HT3 receptors. It has high affinity for histamine H1 receptors, low affinity for dopaminergic receptors, and lacks anticholinergic activity. In spite of these potential beneficial effects of mirtazapine on sleep, no placebo-controlled randomized clinical trials of ABSTRACT mirtazapine in primary insomniacs have been conducted. Mirtazapine was associated with improvements in sleep on normal sleepers and depressed patients. The most common side effects of mirtazapine, i.e. dry mouth, drowsiness, increased appetite and increased body weight, were mostly mild and transient. Considering its use in elderly people, this paper provides a revision about studies regarding mirtazapine for sleep disorders. KEYWORDS: sleep; antidepressive agents; sleep disorders; treatment� A prescrição de hipnóticos aprovados para insônia diminuiu em mais de 50%, enquanto de antidepressivos ultrapassou a dos primeiros. -
Receives Fda Approval for the Treatment of Insomnia
AMBIEN CR™ (ZOLPIDEM TARTRATE EXTENDED-RELEASE TABLETS) CIV RECEIVES FDA APPROVAL FOR THE TREATMENT OF INSOMNIA First and Only Extended-Release Prescription Sleep Medication Indicated for Sleep Induction and Maintenance Covers Broad Insomnia Population Paris, France, September 6, 2005 - Sanofi-aventis (EURONEXT: SAN and NYSE: SNY) announced today that the U.S. Food and Drug Administration (FDA) has approved AMBIEN CR™ (zolpidem tartrate extended-release tablets) CIV, a new extended-release formulation of the number ® one prescription sleep aid, AMBIEN (zolpidem tartrate) CIV, for the treatment of insomnia. AMBIEN CR is non-narcotic and a non-benzodiazepine, formulated to offer a similar safety profile to AMBIEN with a new indication for sleep maintenance, in addition to sleep induction. AMBIEN CR is the first and only extended-release prescription sleep medication to help people with insomnia fall asleep fast and maintain sleep with no significant decrease in next day performance. AMBIEN CR, a bi-layered tablet, is delivered in two stages. The first layer dissolves quickly to induce sleep. The second layer is released more gradually into the body to help provide more continuous sleep. “Insomnia is a significant public health problem, affecting millions of Americans. Insomnia impacts daily activities and is associated with increased health care costs,” said James K. Walsh, PhD, Executive Director and Senior Scientist, Sleep Medicine and Research Center at St. Luke's Hospital in St. Louis, Missouri. “Helping patients stay asleep is recognized as being as important as helping them fall asleep,” said Walsh. “Ambien CR has shown evidence of promoting sleep onset and more continuous sleep". -
Herbal Remedies and Their Possible Effect on the Gabaergic System and Sleep
nutrients Review Herbal Remedies and Their Possible Effect on the GABAergic System and Sleep Oliviero Bruni 1,* , Luigi Ferini-Strambi 2,3, Elena Giacomoni 4 and Paolo Pellegrino 4 1 Department of Developmental and Social Psychology, Sapienza University, 00185 Rome, Italy 2 Department of Neurology, Ospedale San Raffaele Turro, 20127 Milan, Italy; [email protected] 3 Sleep Disorders Center, Vita-Salute San Raffaele University, 20132 Milan, Italy 4 Department of Medical Affairs, Sanofi Consumer HealthCare, 20158 Milan, Italy; Elena.Giacomoni@sanofi.com (E.G.); Paolo.Pellegrino@sanofi.com (P.P.) * Correspondence: [email protected]; Tel.: +39-33-5607-8964; Fax: +39-06-3377-5941 Abstract: Sleep is an essential component of physical and emotional well-being, and lack, or dis- ruption, of sleep due to insomnia is a highly prevalent problem. The interest in complementary and alternative medicines for treating or preventing insomnia has increased recently. Centuries-old herbal treatments, popular for their safety and effectiveness, include valerian, passionflower, lemon balm, lavender, and Californian poppy. These herbal medicines have been shown to reduce sleep latency and increase subjective and objective measures of sleep quality. Research into their molecular components revealed that their sedative and sleep-promoting properties rely on interactions with various neurotransmitter systems in the brain. Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter that plays a major role in controlling different vigilance states. GABA receptors are the targets of many pharmacological treatments for insomnia, such as benzodiazepines. Here, we perform a systematic analysis of studies assessing the mechanisms of action of various herbal medicines on different subtypes of GABA receptors in the context of sleep control. -
Melatonin Protects Against the Effects of Chronic Stress on Sexual Behaviour in Male Rats
MOTIVATION, EMOTION, FEEDING, DRINKING NEUROREPORT Melatonin protects against the effects of chronic stress on sexual behaviour in male rats Lori A. Brotto, Boris B. GorzalkaCA and Amanda K. LaMarre Department of Psychology, 2136 West Mall, Vancouver, BC, Canada V6T 1Z4 CACorresponding Author Received 9 July 2001; accepted 24 August 2001 The effects of chronic mild stress (CMS) on both sexual but not the effects on either spontaneous WDS or WDS in behaviour and wet dog shakes (WDS), a serotonergic type 2A response to the 5-HT2A agonist 1-(2,5-dimethoxy-4-iodophe- (5-HT2A) receptor-mediated behaviour, were explored in the nyl)-2-aminopropane, suggesting a mechanism of action other male rat. In addition, the possible attenuation of these effects than exclusive 5-HT2A antagonism. These results are the ®rst by chronic treatment with melatonin, a putative 5-HT2A to demonstrate that melatonin signi®cantly protects against the antagonist, was examined. The CMS procedure resulted in a detrimental effects of a chronic stressor on sexual behaviour. signi®cant increase in WDS and an overall decrease in all NeuroReport 12:3465±3469 & 2001 Lippincott Williams & aspects of sexual behaviour. Concurrent melatonin administra- Wilkins. tion attenuated the CMS-induced effects on sexual behaviour, Key words: Chronic mild stress; 5-HT2A receptors; Melatonin; Serotonin; Sexual behaviour INTRODUCTION vioural effect of melatonin is mediated via a reduction in The chronic mild stress (CMS) procedure, in which rats are 5-HT2A receptor activity rather than altered central 5-HT2A repeatedly exposed to a variety of mild stressors, is receptor density [8]. The demonstration that melatonin associated with behavioural and biochemical sequelae that reduces the concentration-dependent 5-HT2A receptor- are commonly associated with anhedonia [1]. -
Sedative Hypnotics
Louisiana Medicaid Sedative Hypnotics The Louisiana Uniform Prescription Drug Prior Authorization Form should be utilized to request: • Prior authorization for non-preferred sedative hypnotics; OR • Clinical authorization for tasimelteon (Hetlioz®, Hetlioz LQ™). Additional Point-of-Sale edits may apply. Some of tThese agents may have Black Box Warnings and/or may be subject to Risk Evaluation and Mitigation Strategy (REMS) under FDA safety regulations. Please refer to individual prescribing information for details. ___________________________________________________________________________________ Non-Preferred Agents Approval Criteria for Initial and Reauthorization Requests • There is no preferred alternative that is the exact same chemical entity, formulation, strength, etc.; AND • The requested medication has been prescribed for an approved diagnosis (if applicable); AND • Previous use of a preferred product - ONE of the following is required: o The recipient has had a treatment failure with at least one preferred product; OR o The recipient has had an intolerable side effect to at least one preferred product; OR o The recipient has documented contraindication(s) to all of the preferred products that are appropriate to use for the condition being treated; OR o There is no preferred product that is appropriate to use for the condition being treated; AND • By submitting the authorization request, the prescriber attests to the following: o The prescribing information for the requested medication has been thoroughly reviewed, including