AB176 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2021 Scientific Abstract Sessions

1807 Featured Poster Session National Hospital1, National Institute of Allergy and Infectious Diseases2 Friday, February 26, 2021, 04:35 pm - 05:50 pm 009 Androgen Receptor Signaling Augments Regulatory T Cell Functions to Attenuate Allergic Airway Inflammation 001 Penicillin Allergy Evaluation in Pregnancy Impacts Antibi- Vivek Gandhi, PhD1, Jacqueline Cephus, MS1, Nowrin Chowd- otic Utilization and Neonatal Clinical Outcomes hury1, Allison Norlander, PhD1, Stokes Peebles, MD FAAAAI2, 1 2 Jamie Waldron, MD , Nerlyne Desravines, MD , Kim Bog- Dawn Newcomb, PhD1, Vanderbilt University Medical Center1, 3 4 gess, MD , Mildred Kwan, MD PhD FAAAAI , University of Vanderbilt Univ School of Medicine2 1 North Carolina Chapel Hill , University of North Carolina at 010 Dupilumab Treatment Leads to Clinical Asthma Remission in 2 3 4 Chapel Hill , UNC , University of North Carolina Patients With Uncontrolled Moderate-to-Severe Asthma With 002 Nebulized MIDD0301 is Efficacious in Allergic and Micro- Type 2 Inflammation bial Lung Inflammation Models Ian Pavord, MD1, William Busse, MD FAAAAI2, Elliot Israel, 1 2 Leggy Arnold , Brandon Mikulsky, BS , M. S. Rashid Roni, MD FAAAAI3, Stanley Szefler, MD FAAAAI4, Zhen Chen, 1 1 1 3 MS, RA , Daniel Knutson , Md Yeunus Mian , Gene Yocum , PhD5, Nadia Daizadeh6, David Lederer5, Leda Mannent, MD6, 3 1 1 Charles Emala, MD , Nicolas Zahn , Daniel Webb , James Nikhil Amin, MD5, Elizabeth Laws6, Marcella Ruddy, MD5, 4 1 1 2 Cook , Douglas Stafford , UW Milwaukee , Pantherics Inc. , Paul Rowe, MD6, Yamo Deniz5, Asif Khan6, Yi Zhang5, NIHR 3 4 Columbia University , UW-Milwaukee Oxford Biomedical Research Centre, University of Oxford1, Uni- 003 Significant Hypogammaglobulinemia in Patients Receiving versity of Wisconsin School of Medicine and Public Health2, Har- CAR T-cell therapy vard Medical School and Brigham & Women’s Hospital3, 1 1 Sara Barmettler, MD , Nancy Yang , Jocelyn Farmer, MD University of Colorado School of Medicine4, Regeneron Pharma- 1 2 1 PhD , Aidan Long, MD FAAAAI , Marcela Maus, MD/PhD , ceuticals, Inc.5, Sanofi6 1 1 Carlos Camargo, MD DrPH , Massachusetts General Hospital , 011 Implementation of Virtual Training Visits During the Corona- 2 Mass General Hospital virus Pandemic: a Nursing Perspective 004 SARS-CoV-2 entry factors are expressed in nasal, ocular, and Linda Trotto, RN, BSN, CRNI1, Christopher Vanname, RN1,Tim- oral tissues: implications for COVID-19 prophylaxes/thera- othy Kingas, RN1, Specialty Pharmacy Nursing Network, Inc.1 peutics Ivan Lee1, Tsuguhisa Nakayama1, Sizun Jiang1, Yury Goltsev1, Christian Schurch€ 1, Bokai Zhu1, David McIlwain1, Pauline Chu1, Han Chen1, Alexandar Tzankov2, Matthias Matter2, Jaya- Drug Hypersensitivity 1 1 kar Nayak , Garry Nolan , Stanford University School of Med- 012 Allergological evaluation of hypersensitivity drug reactions to 1 icine , Institute of Medical Genetics and Pathology, University betalactams in children 2 of Basel, Switzerland Isabel Torres Rojas, CME1, Ana Prieto-Moreno2, Maria Desam- 005 Picornavirus Infection of Esophageal Epithelial Cells parados Cervera2, Diana Perez-Alzate2, Francisco Javier Ruano2, 1 2 Vinay Goswamy , Paul Fichtinger, BS , Elizabeth McKernan, Maria Luisa Somoza Alvarez 2, Paula Lopez-Gonz alez2, Marıa 1 3 BS , Sameer Mathur, MD PhD FAAAAI , University of Wiscon- Vazquez De La Torre2, Elisa Haroun-Dıaz2, Natalia Blanca- 1 2 sin - Madison , University of Wisconsin , University of Wiscon- Lopez 2, Gabriela Canto, MD, PhD2, Infanta Leonor University 3 sin School of Medici Hospital1, Infanta Leonor University Hospital, Madrid, Spain2 006 Food Reintroduction after Passing an Oral Food Challenge: 013 In pediatric patients who have penicillin skin testing with mi- A Cross-Sectional Structured Interview-Based Assessment of nor determinants, an oral challenge isn’t needed Barriers, Challenges, and Impact on Quality of Life Michael D’Netto, MD1, Dayne Voelker, MD2, Miguel Park, MD3, 1 1 Christina Ditlof , Roxanne Hummel , Samantha Wong, MSc, Mayo Clinic School or Graduate Medical Education1, Washington 1 1 1 RD , Mara Alexanian-Farr, MSc, RD , Slavka Zahrebelny , Jen- University School of Medicine2, Mayo Clinic3 1 1 1 nifer Hoang , Lisa Hung , Julia Upton, MD , ADELLE ATKIN- 014 Multiple drug allergies as a risk factor for IgE mediated pen- 1 1 1 SON, MD, FRCP , Maria Asper, MD , David Hummel, MD , icillin drug allergy in a pediatric population 1 1 Thomas Eiwegger, MD , Hospital for Sick Children Dayne Voelker, MD1, Michael D’Netto, MD2, Miguel Park, MD3, 007 Identification of severe eosinophilic chronic rhinosinusitis Washington University School of Medicine1, Mayo Clinic School based on eosinophil, mast cell and basophil microparticles of Graduate Medical Education2, Mayo Clinic3 in nasal lavage fluids 015 Obesity is Associated with an Increased Prevalence of Penicil- 1 1 Toru Takahashi, MD, PhD , Atsushi Kato, PhD , Lydia Suh, lin Allergy 1 2 2 BS , Roderick Carter, BS , Whitney Stevens, MD, PhD , Caro- Sarah Abbassi1, Eugenio Capitle, MD2, Radhika Trivedi, BA1, 2 2 line Price, CCRC , James Norton, MS , Anju Peters, MD MSCI Alan Wolff, MD3, Rutgers University1, Rutgers-New Jersey Med- 2 2 2 FAAAAI , Leslie Grammer, MD FAAAAI , Kevin Welch, MD , ical School2, Department of Veteran3 2 2 Stephanie Shintani Smith, MD , David Conley, MD , Sergejs 016 Ceftriaxone Allergy in Pediatric Population 2 2 2 Berdnikovs, PhD , Bruce Tan, MD MS , Robert Kern, MD , Morgan Gold1, Daniel Sehayek2, Sofianne Gabrielli, MSc3, Eli- 2 Robert Schleimer, PhD FAAAAI , Northwestern University, ssa Abrams, MD FRCPC4, Andrew O’Keefe, MD5, Jennifer Pro- 1 Feinberg School of Medicine , Northwestern University Fein- tudjer, PhD6, ELANA LAVINE7, Tracy Pitt8, ADELLE 2 berg School of Medicine ATKINSON, MD, FRCP7, Thomas Eiwegger, MD7, Christine 008 Food-allergic children have decreased peripheral regulatory McCusker, MD MSc3, Moshe Ben-Shoshan, MD FAAAAI3, B cells and altered B cell responses to IL-10 McGill University, Montreal, Quebec, Canada1, Universite Laval, 1 1 Adora Lin, MD PhD , Hemant Sharma, MD, MHS , Pamela Quebec City, Quebec, Canada2, Division of Allergy and Clinical 2 1 Guerrerio, MD PhD , Catherine Bollard, MD , Children’s Immunology, Montreal Children’s Hospital, Montreal, Quebec, J ALLERGY CLIN IMMUNOL Abstracts AB177 VOLUME 147, NUMBER 2

Canada3, Section of Allergy and Clinical Immunology, University Eric Macy, MD FAAAAI1, Thomas McCormick, PhD2, John of Manitoba, Winnipeg, Manitoba, Canada4, Faculty of Medicine, Adams, PhD3, William Crawford, MD4, Myngoc Nguyen, MD Memorial University of Newfoundland, St John’s, NL, Canada5, FAAAAI5, Anna Davis, PhD2, Elizabeth McGlynn2, SCPMG-Kai- University of Manitoba, Winnipeg, Manitoba, Canada6, Division ser Permanente San Diego1, Kaiser Permanente2, Kaiser Perma- of Allergy and Clinical Immunology, U of T, Hospital for Sick nente Bernard J. Tyson School of Medicine3, Kaiser South Bay Children, Toronto, ON, Canada7, Queen’s University, Kingston, Medical Center4, Kaiser Permanente Oakland5 Ontario, Canada8 025 Corticosteroid Hypersensitivity Skin Testing at a Large Ter- 017 Descriptive study of selective reactions to NSAIDs in a referral tiary Care Network; 2008-2018 Hospital Maria Sanchez-Valenzuela, MD1, Ismael Carrillo-Martin, MD2, Ana MarAa~ Prieto-Moreno Pfeifer, CME1, Isabel Torres-Ro- Matthew Rank, MD FAAAAI3, Gerald Volcheck, MD FAAAAI3, jas1, Maria Desamparados Cervera1, Diana Perez-Alzate1, Fran- Miguel Park, MD4, Alexei Gonzalez-Estrada, MD4, Saint Barna- cisco J. Ruano1, Maria Luisa Somoza Alvarez 1, Paula Lopez- bas Hospital1, Mayo Clinic Florida2, Mayo Clinic and Founda- Gonzalez1, Marıa Vazquez De La Torre1, Elisa Haroun-Dıaz1, Na- tion3, Mayo Clinic4 talia Blanca-Lopez 1, Gabriela Canto, MD, PhD1, Infanta Leonor 026 Incidence And Risk Factors of Angiotensin-Converting Enzyme University Hospital1 Inhibitor-Induced Angioedema: A Large Case-Control Study 018 The Association of Multiple Drug Allergies and Vocal Cord Juan Garcia-Saucedo1, Ismael Carrillo-Martin, MD1,JorgeTrejo- Dysfunction Assessed by the Pittsburgh VCD Index Gutierrez, MD1, Matthew Rank, MD FAAAAI1, Gerald Volcheck, Megan McCarty1, Anisha Prabakaran, PA1, Merritt Fajt, MD MD FAAAAI1, Miguel Park, MD1, Alexei Gonzalez-Estrada, FAAAAI2, Andrej Petrov, MD FAAAAI2, UPMC1, University of MD1, Mayo Clinic1 Pittsburgh Medical Center2 027 The diagnosis of non-life-threatening immediate penicillin al- 019 Basophil Activation Marker Selection, CD63 or CD203c, Im- lergy should not rest upon low sIgE results between 0.10 proves Sensitivity of Basophil Activation Test Depending on kUA/L and 0.35 kUA/L in isolation. the Clinical Entity in Immediate Allergic Reactions to Betalac- Marie-Line Van Der Poorten, MD1, Athina Van Gasse1, Margo tams. Hagendorens, MD PhD2, Margaretha Faber, MD PhD1, Leander Ruben Fernandez-Santamar ıa1, Gador Bogas Herrera, MD2, De Puysseleyr1, Jessy Elst, MD1, Christel Mertens1, Anca Chir- Maria Salas3, Adriana Ariza Veguillas, PhD4, Ana Molina iac3, Didier Ebo, MD PhD FAAAAI4, Vito Sabato, MD1, Univer- Bueno4, Cristobalina Mayorga, PhD5, Maria Torres JaA~Ón, MD sity of Antwerp1, University of Antwerp - Belgium2, University PhD FAAAAI6, Tahia Fernandez, PhD5, Allergy Research Group, Hospital of Montpellier3, University Antwerp4 Instituto de Investigacion Biomedica de Malaga-IBIMA, Univer- 028 Non-irritating skin test concentrations for ceftazidime and az- sity of Malaga-UMA, Malaga, Spain1, Allergy Unit, Hospital Re- treonam in patients with a documented beta-lactam allergy. gional Universitario de Malaga-HRUM, Malaga, Spain2, Allergy Marie-Line Van Der Poorten, MD1, Margo Hagendorens, MD Unit, Hospital Regional Universitario de Malaga-HRUM, Malaga, PhD2, Athina Van Gasse1, Margaretha Faber, MD PhD1, Leander Spain3, Allergy Research Group, Instituto de Investigacion Bio- De Puysseleyr1, Jessy Elst, MD1, Antonino Romano3, Didier Ebo, medica de Malaga-IBIMA, Malaga, Spain4, Allergy Research MD PhD FAAAAI4, Vito Sabato, MD1, University of Antwerp1, Group, Instituto de Investigacion Biomedica de Malaga-IBIMA, University of Antwerp - Belgium2, IRCCS Oasi Maria S.S., Allergy Unit, Hospital Regional Universitario de Malaga- Troina, Italy3, University Antwerp4 HRUM, Malaga, Spain5, Allergy Unit, Hospital Regional Univer- 029 Direct challenges for delabeling drug allergy in pediatric pa- sitario de Malaga-HRUM, University of Malaga-UMA, Malaga, tients Spain6 Sara Concha1, Josefina Castagnoli1, Florencia Neumann1, Arturo 020 Online Antibiotic Allergy Decision Support Tool Improves Borzutzky, MD FAAAAI1, Rodrigo Hoyos1, Pontificia Universi- Management of Beta Lactam Allergies dad Catolica de Chile1 Theresa Dunham, MD1, Danielle Fasani, PharmD1, Elizabeth 030 An enhanced technique exploring the role of T cells in drug al- Lippner, MD1, Elwyn Moir, MMH1, Bonnie Halpern-Felsher, lergies PhD1, Rebecca Gardner, MS1, Vandana Sundaram, MPH1, Anne Carla Irani1, Joelle Dagher2, Diane Antonios-Gholam2, Marc Liu, MD1, Stanford University1 Pallardy3, Hayat Azouri-Tannous4, Hotel Dieu De France,St Jo- 021 Evaluation of Alpha Gal in Vaccines and Medications using a seph University, Lebanon1, Toxicology Laboratory, Saint Joseph Human Monoclonal IgE Antibody University, Faculty of Pharmacy, Beirut, Lebanon2, Universite Emily Campbell1, Stokes Peebles, MD FAAAAI2, Cosby Stone, Paris-Saclay, Inserm, Inflammation microbiome immunosurveil- MD MPH1, Jian Zhang1, Azadeh Hadadianpour1, Joshua Doyle1, lance3, Toxicology Laboratory, Saint Joseph University, Faculty Scott Smith, MD PhD1, Vanderbilt University Medical Center1, of Pharmacy, Beirut, Lebanon4 Vanderbilt Univ School of Medicine2 031 Stratifying Penicillin Allergy Risk in a Pediatric Population 022 Carboplatin Skin Test Conversion: A Pilot Study of Onco-Gy- Nicole Koutlas1, Joanne Band1, Michael Smith1, Amy Stallings, necology – Allergy Multidisciplinary Care Team for Carbo- MD FAAAAI1, Duke University1 platin Hypersensitivity 032 Immune checkpoint inhibitors alter cytokine production by Apinya Chungcharoenpanich1, Wannada Laisuan2, Ticha Lim- human PBMC: implications for increased allergic reactions suwan, MD3, Ramathibodhi hospital, Bangkok, Thailand1, Rama- in subjects on immune checkpoint inhibitor therapy thibodi Hospital, Mahidol University2, Ramathibodee Hospital3 Evelyn Wang1, Elena Goleva, PhD1, Kathryn Vang, MS1, Jeffrey 023 Non-Penicillin Antibiotic Allergy in children: Removing the Kern, MD1, Mario LaCouture, MD2, Taras Lyubchenko, PhD3, Label with an Oral Challenge Donald Leung, MD PhD FAAAAI1, National Jewish Health1, Grant Pickett1, Larraine Lyter-Reed, MSN RN FNP-BC1, Meera Memorial Sloan Kettering Cancer Center2, National Jewish Gupta, MD FAAAAI2, Aikaterini Anagnostou, MD MSc PhD Healh3 FAAAAI3, Baylor College of Medicine1, Baylor/ Texas Children2, 033 Outcomes in Hospitalized, Organ Transplant Patients with a Texas Children3 Penicillin Allergy Label in the United States, 2005-2014 024 Population-based incidence of new ampicillin, cephalexin, cef- Jared Nelson, DO1, Ismael Carrillo-Martin, MD2, Wendelyn aclor, and sulfonamide antibiotic ‘‘allergies’’ in exposed indi- Bosch, MD2, Lisa Brumble2, Justin Oring2, Miguel Park, MD1, viduals with and without preexisting ampicillin, cephalexin, Alexei Gonzalez-Estrada, MD1, Mayo Clinic1, Mayo Clinic or cefaclor ‘‘allergies’’ Florida2 AB178 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2021

034 A Review of Drug Reaction with Eosinophilia and Systemic 045 Needlessly Avoiding Meropenem Use In Hospitalized Patients Symptoms in the FDA Adverse Event Reporting System L Marin1,MJPenalver~ 1, B Moya1, JF Crespo1, R Mielgo1,12de (FAERS) Octubre Hospital1 Sara Bluestein1, Roger Yu2, Cosby Stone, MD MPH1, Elizabeth 046 The Long-term Impact of Beta-lactam Antibiotic Allergy Test- Phillips, MD FAAAAI FIDSA3, Vanderbilt University Medical ing - A Matched Case-control Study Center1, Vanderbilt University Medical Center & Pritzker School Jason Trubiano, MD PhD1, Nada Marhoon2, Sara Vogrin2, Kyra or Medicine2, Prof3 Chua1, Natasha Holmes1, Austin Health1, University of 035 Beta-Lactam Allergy Labels among Pneumonia Admissions at Melbourne2 an Academic Children’s Center 047 The Role of In Vivo and Ex Vivo Diagnostic Tools for Antibi- Ryan LaHood, MD1, Rebecca Koenigsberg, DO1, An Huynh, otic-Associated Severe Cutaneous Adverse Reactions MD1, James Slaven, MS, MA2, Michelle Kussin, PharmD1, Ana Copaescu, MD1, University of Montreal1 John Manaloor, MD1, Riley Hospital for Children/ Indiana Uni- versity School of Medicine1, Indiana University School of Medicine2 036 Guiding Inpatient Hospital Services in Performing Direct An- tibiotic Challenges using Telemedicine Anaphylaxis Timothy Chow1, Alicia Alvarez, MD1, David Khan, MD 048 Analysis of Anaphylaxis Events in Colorado Public Schools, FAAAAI1, University of Texas Southwestern1 2015-2019 037 Delayed onset localized urticarial reactions to Dupilumab Bruce Lanser, MD FAAAAI1, Sarah Blumenthal, MSN, RN,2, Jennifer Xu, MD1, Jennifer Shih, MD FAAAAI1, Merin Kalan- James Crooks, PhD, MS1, National Jewish Health1, Colorado De- gara, MD1, Emory University1 partment of Education2 038 New human immunoglobulin in Brazil: should we use? 049 Clinical outcomes of patients with idiopathic anaphylaxis re- Caroline Ferreira, MD1, Nathalia Vital, MD1, Pedro Henrique ceiving omalizumab Bubach1, Raissa Roque, MD1, Fernanda Pires Cecchetti Vaz1, Ra- Lauren Kaminsky1, Kestutis Aukstuolis, DO2, Daniel Petroni, fael Saldanha1, Barbara Cristina Ramos1, Maria Gabriela Viana de MD PhD FAAAAI3, Taha Al-Shaikhly, MBChB1, Penn State Col- Sa1, Luana Medeiros1, Luiza Salvador Schmid1, Rafaela lege of Medicine1, University of Washington2, Northwest Asthma Guimar~aes1, Ligia Maria O. Machado1, Mariana Pimentel1, Can- Allergy Center3 dida Rizzo, MD PhD1, Carolina Aranda1, Dirceu Sole, MD PhD 050 Pediatric Intensive Care Unit Admissions for Anaphylaxis at FAAAAI1, Federal University of Sao Paulo1 Children’s Medical Center in Dallas 039 Multiple Drug Intolerance Syndrome in Fibromyalgia Kelly Boyd, MD, Christopher Parrish, MD FAAAAI1, J. Andrew Alicia Alvarez, MD1, David Khan, MD FAAAAI1, University of Bird, MD FAAAAI2, University of Texas Southwestern1,UT Texas Southwestern1 Southwestern Medical Center2 040 Rituximab Desensitizations in Pediatric and Adult Patients at 051 Incidence Of Fatal Anaphylaxis: A Systematic Review And a Tertiary Care Center Meta-analysis Of Observational Studies. Sources Of Informa- Alekist Quach, MD1, Anthony Wong, PharmD1, Lulu Tsao, tion MD1, Angela Chang, MD1, Lauren Sanchez, MD1, Fanny Li, Lucia Gonzalez-Bravo, MD1, Jimena Laiseca-Garcia1, Sabela PharmD1, Iris Otani, MD FAAAAI1, UCSF1 Codesido, MD1, Marianela Brandoni-Petrone1, Patricia Andrade- 041 THE ROLE OF PIPERACILLIN AS A TRIGGER IN DRUG Garban1, Marta Goyanes-Malumbres1, Miguel Tejedor, MD ALLERGY. A RETROSPECTIVE STUDY. PhD1, Hospital Universitario Fundacion Alcorcon1 Almudena Delgado Gonzalez 1, Marta Isabel Rodriguez Cab- 052 Clinical characteristics of fatal anaphylaxis: A Spanish reros2, Iria Roibas Veiga1, Miriam Barrios Albajar2, Marta nationwide 17- year series Gema Lopez San Martin3, Alfredo Iglesias Cadarso3, Resident al- Jimena Laiseca Garcia, MD1, Lucia Gonzalez-Bravo, MD1, Sa- lergist1, MD Allergist2, Allergist3 bela Codesido, MD1, Marianela Managua Brandoni Petrone1, 042 Cytosolic Phospholipase A2 (PLA2G4A) Polymorphisms Asso- Marta Goyanes Malumbres1, Patricia Alejandra Andraden Gar- ciated with Acute Urticaria/angioedema Induced by Nonste- ban1, Miguel A. Tejedor1, Hospital Universitario Fundacion roidal Anti-inflammatory Drugs Alcorcon1 Raquel Jurado Escobar, Resercher1, Jose Triano-Cornejo1, In- 053 Assigning Causality for Abnormal Tryptases: a-Gal and maculada Dona~ 2, Natalia Perez Sanchez2, Gador Bogas Herrera, Other Causes of Anaphylaxis, Mastocytosis and More MD2, Joan Bartra, MD, PhD3, Jose Laguna, MD4, Maria Torres Alice Knoedler, MD1, Matthew Straesser, MD2, Jeffrey Wilson, ~ 2 1 JaAÓn, MD PhD FAAAAI , Jose Cornejo-Garcia , Allergy MD PhD1, University of Virginia1, Central Pennsylvania Asthma Unit, IBIMA, Regional University Hospital of Malaga, UMA, Ma- and Allergy2 laga, Spain1, Research Laboratory, IBIMA, Regional University 054 Effect of Prescription Drugs on Anaphylaxis Severity and Hospital of Malaga, UMA, Malaga, Spain2, Unitat dAllergia, Ser- Symptoms vei de Pneumologia, Hospital Clinic, Universitat de Barcelona, Sofianne Gabrielli, MSc1, Ann Clarke2, Judy Morris3, Jocelyn Barcelona, Spain3, Allergy Unit, Allergo-Anaesthesia Unit, Hos- Gravel4, Rodrick Lim, MD5, Edmond Chan, MD FAAAAI6, pital Central de la Cruz Roja, Madrid, Spain4 Ran Goldman7, Andrew O, MD8, Jennifer Gerdts9, Derek Chu, 043 The Burden Of Self-Reported Adverse Drug Reactions in Pa- MD PhD10, Julia Upton, MD11, Adam Bretholz1, Christine tients Referred To An Outpatient Allergy Practice At A Ter- McCusker, MD MSc12, Xun Zhang, PhD13, Moshe Ben-Shoshan, tiary Referral Center MD FAAAAI1, Laura May Miles, LLM1, McGill University Becky Buelow1, Suhita Alluri, Resident2, Medical College of Health Centre1, University of Calgary2, Sacre-Coeur Hospital3, Wisconsin/Children’s Hospital of Wisconsin1, MCW2 CHU Sainte-Justine4, Children’s Hospital at London Health Sci- 044 The Association Between Risk Stratification Models And The ence Centre5, BC Children’s Hospital6, University of British Co- Likelihood of Positive Penicillin Skin Tests lumbia7, Memorial University8, Food Allergy Canada9, Margaret Kuder, MD1, John McDonnell, MD2, Katherine McMaster University10, The Hospital for Sick Children11, Mon- Weller, MD2, Xiaofeng Wang2, Manshi Li2, David Lang, MD treal Children12, Research Institute of McGill University Health FAAAAI2, Cleveland Clinic1, Cleveland Clinic Foundation2 Centre13 J ALLERGY CLIN IMMUNOL Abstracts AB179 VOLUME 147, NUMBER 2

055 Incidence of and Risk Factors for Chemotherapy-Induced An- Center3, IAA Clinical Immunology Laboratory4, Takeda Pharma- aphylaxis Agents in the United States ceuticals, Inc.5, Takeda Pharmaceuticals6, Takeda7 Leyla Bojanini1, Ismael Carrillo-Martin, MD1, Yenny Moreno 065 Real World Data of Canadian Adults Living with Angioe- Vanegas, MD2, Lyda Cuervo-Pardo, MD3, Ricardo Zwiener, dema: Part 4 - Health Economic Burden MD4, Alexei Gonzalez-Estrada, MD1, Mayo Clinic, Jacksonville, Jacquie Badiou1, Anne Rowe1, Michelle Cooper1, Kim Roberts1, FL, USA1, St. Elizabeth Medical Center, Boston, MA, USA2, Uni- Daphne Dumbrille1, Robert Bick2, marguerite Dao1, Suzanne versity of Florida, Gainesville, FL, USA3, Hospital Universitario Kelly, PhD3, William Yang, MD FAAAAI4, Hereditary Angioe- Austral, Buenos Aires, Argentina4 dema Canada1, Health Policy Consultant2, Red Maple Trials 056 Descriptive study of Anaphylaxis reactions induced by drugs Inc., Ottawa, ON3, Ottawa Allergy Research Corporation, Ottawa, in a referral hospital ON4 Natalia Blanca-Lopez 1, Ana MarAa~ Prieto-Moreno Pfeifer, 066 Berotralstat Consistently Demonstrates Reductions in Attack CME1, Diana Perez Alzate, MD2, Isabel Torres Rojas, CME1, Ma- Frequency in Hereditary Angioedema (HAE) Irrespective of ria Luisa Somoza Alvarez1, Elisa Haroun-Diaz1, Francisco Javier Baseline Attack Rate: Subgroup Analysis from the APeX-2 Ruano Perez1, Maria Vazquez de La Torre3, Paula Lopez Gonza- Trial lez1, Maria Desamparados Cervera1, Maria Gabriela Canto Diez1, H. Henry Li, MD, PhD1, Jessica Best, DHSc, PA2, Sharon Mur- Infanta Leonor University Hospital1, Hospital Universitario In- ray, PhD2, Heather Iocca, PhD3, Raffi Tachdijan, MD4, Institute fanta Leonor2, Infanta LeonorUniversity Hospital3 for Asthma and Allergy, Chevy Chase, MD1, BioCryst Pharma- 057 Patent Blue Dye: Allergen Increasing ceuticals2, BioCryst Pharmaceuticals, Inc.3, AIRE Medical of Leticia Domınguez-Cereijo1, M. D. Rodrıguez-Bote1, A. Conde- Los Angeles, Santa Monica, CA4 Alcaniz~ 1, P. Guardia-Martınez1, Virgen Macarena University 067 Rituximab in the Treatment of Acquired Angioedema Hospital1 Tracy Hwangpo1, University of Alabama Birmingham1 058 Modeling and Simulation Strategy to Support the Develop- 068 Like father, but not like daughter: familial cases of common ment of ARS-1 (Intranasal Epinephrine) for Adult and Pediat- variable immunodeficiency and de novo hereditary angioe- ric Subjects with Systemic Allergies dema type 1/2 Jeff Barrett1, Critical Path Institute1 Angeliki Barlas1, Amin Kanani1, University of British Columbia1 059 The Heterogeneity Of State-Specific Epinephrine Training 069 Malignancy and Immune Disorders in Patients with Heredi- Program Listing Requirements In The United States tary Angioedema Madison Oxford, BA1, Alice Hoyt, MD1, Code Ana of The Teal Peter Stepaniuk1, Amin Kanani1, Division of Allergy and Immu- Schoolhouse1 nology, Department of Medicine, University of British Columbia, 060 Role of Neurogenic Inflammation, especially Calcitonin Gene- Vancouver, British Columbia, Canada1 related Peptide (CGRP), in Anaphylactic Reaction of Children 070 Reduction in Attacks in Hereditary Angioedema (HAE) With with Food Allergy Berotralstat is Consistent Regardless of Prior Prophylactic Kenichi Tokuyama1, Shunichi Ogawa1, Takeshi Koga1, Keisuke Treatment: A Subgroup Analysis of the Phase 3 APeX-2 Trial Okada1, Yutaka Ueda1, Eiji Morita1, Toshiko Itazawa, MD/ John Anderson, MD1, Remi Gagnon, MD MSc2, Jessica Best, PhD1, Department of Pediatrics, Saitama Medical DHSc, PA3, Sharon Murray, PhD3, Heather Iocca, PhD4, Karl University1 Sitz, MD FAAAAI5, Alabama Allergy & Asthma Center1, Clini- que Specialisee en Allerfie de la Capitale2, BioCryst Pharmaceu- ticals3, BioCryst Pharmaceuticals, Inc.4, Little Rock Allergy and Asthma Clinic, P5 Urticaria and Angioedema 071 Rituximab as Treatment of Chronic Idiopathic Urticaria 061 Understanding Disease Mechanisms of Hereditary Angioe- Saira Zafar1, Mark Weinstein2, Alan Wolff, MD3, Rutgers dema With Potential Therapeutic Implications Through NJMS1, Hudson-Essex Allergy, LLC2, Department of Veteran3 RNA Sequencing Transcriptome Profiling 072 Diagnosis of hereditary Angioedema by genetic mutation of Umesh Singh, MD PhD1, Debayoti Ghosh, PhD2, Jonathan Bern- coagulation factor XII stein, MD FAAAAI3, University of Cincinnati1, University of Cin- Natasha Ferraroni, MD1, Gabriela Yoshimoto2, Camila Vero- cinnati College of Medicine2, University of Cincinnati; Bernstein nez3, Luiza Silva2, Marina Batista2, Bruna Azevedo4,Jo~ao Pes- Allergy Group, Inc3 quero4, GEBRAEH (Brazilian Hereditary Angioedema Study 062 Lanadelumab as treatment for acquired angioedema with low Group)1, UniCEUB2, Universidade Federal de Sao Paulo -UNI- C1-inhibitor, a 3-patient case series FESP3, Universidade Federal de S~ao Paulo - UNIFESP4 Tonia Afshan1, Paul Faybusovich, DO2, Timothy Craig, DO 073 Long-term Impact of Lanadelumab on Patients with Heredi- FAAAAI3, Theodore Kelbel, MD FAAAAI4, Spectrum Health / tary Angioedema (HAE) Type 1/2: Patient Reported Outcome Michigan State University / Helen DeVos Children’s Hospital Pe- (PRO) Findings from the HELP Open-label Extension Study diatrics Residency Program1, Penn State University / Milton S (OLE) Hershey Medical Center Allergy/Immunology Fellowship Pro- Maureen Watt1, Marcus Maurer, MD2, Giovanna Devercelli3, gram2, Penn State University / Milton S Hershey Medical Center3, Kim Paes, Clinical Scientist3, Antoine Regnault4, Julliette Meu- Spectrum Health / Helen DeVos Children’s Hospital4 nier4, Laurine Bunod4, Marc Riedl, MD MS5, William Lumry, 063 Despite Prophylactic Treatments, Break-through Attacks Con- MD FAAAAI6, Takeda Pharmaceuticals International AG, Zurich, tinue among Patients with Hereditary Angioedema Switzerland1, Charite – Universit€atsmedizin Berlin, Germany2, Cristine Radojicic, MD1, Jessica Best, DHSc, PA2, Jinky Ros- Takeda Pharmaceutical Company Limited, Lexington, MA3, selli, MPH3, Duke Asthma, Allergy, and Aiway Center1, BioCryst Modus Outcomes, Lyon, France4, University of California San Pharmaceuticals, Inc.2, BioCryst Pharmaceuticals3 Diego, San Diego, CA5, Allergy and Asthma Research Associates, 064 Response to lanadelumab is not affected by race and ethnicity: Dallas, TX6 findings from phase 3 studies 074 Long-term efficacy and safety of lanadelumab by baseline at- Timothy Craig, DO FAAAAI1, Rafael Zaragoza-Urdaz2, John tack rates in hereditary angioedema Anderson, MD3, Huamin Li4, Kim Paes5, Clinical Scientist5, Aleena Banerji, MD FAAAAI1, Marc Riedl, MD MS2, Raffi Hong Ren, MS6, Salome Juethner, NP7, Penn State University1, Tachdjian, MD MPH FAAAAI3, Christina Nurse, PhD4, Ming Rafael H Zaragoza Urdaz MD CSP2, Alabama Allergy & Asthma Yu 4, Sorena Kiani5, Massachusetts General Hospital1, University AB180 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2021

of California, San Diego2, UCLA Division of Allergy, Immunol- 086 Comorbidities in Patients with Chronic Urticaria ogy & Rheumatology3, Takeda4, Barts Health NHS Trust5 Mariana Fernandes, MD1, Paula Argolo2, Bruna Gehlen, MD2, 075 Biomarkers associated with chronic spontaneous urticaria se- Alanna Batalha, MD2, Jorge Kalil, MD, PhD2, Antonio^ Motta2, verity in children Rosana Agondi, MD PhD2, Clinical Immunology and Allergy Di- Lydia Zhang, MD1, Michelle Le, MD1, Sofianne Gabrielli, MSc1, vision, University of S~ao Paulo1, University of S~ao Paulo2 Elena Netchiporouk, MD, MSc1, Luis Felipe Ensina, MD, PhD2, Shoshana Greenberger, Dermatology3, Sharon Baum4, Fatemeh Jafarian, MD1, Xun Zhang, PhD5, Moshe Ben-Shoshan, MD FAAAAI1, McGill University Health Centre1, Federal University of S~ao Paulo2, Sheba Medical Center Israel3, Chaim Sheba Med- Atopic and Contact Dermatitis ical Center4, Research Institute of McGill University Health 087 A Randomized Controlled Trial of an Educational Handbook Centre5 for Caregivers of Children with Atopic Dermatitis 076 Allergic Rhinitis and Chronic Spontaneous Urticaria Jennifer Lebovidge, PhD1, Corinna Rea, MD, MPH1, Karol Tim- Iwona Dziewa, DO1, Jamie Rosenthal, MD2, Taha Al-Shaikhly, mons, RN MS CPNP1, Sophia Delano, MD, MPP1, Kimberly MBChB1, Penn State College of Medicine1, George Washington Greco, MPH1, Frances DeFreitas, BS1, Felice Chan, BA1, Tiffany University Medical Faculty Associates2 Jeong, BA1, Melissa Rosen, BA1, Lynda Schneider, MD 077 Urticaria Knowledge and Management among Pediatric Pro- FAAAAI1, Boston Children’s Hospital1 viders in a Chicago Academic Center 088 Early Clinical Efficacy After Dupilumab Therapy for Adult Ozge Nur Aktas1, Alan Schwartz, PhD1, Andrea Pappalardo, MD Severe Atopic Dermatitis in a Real-World Setting FAAAAI1, University of Illinois College of Medicine at Chicago1 Paloma Poza Guedes, MD PhD1, Ruperto Gonzalez Perez, MD 078 Chronic urticaria in children: a real-life study PhD1, Elena Mederos Luis1, Victor Matheu, MD, PhD1, Cristina Larissa Brandao~ 1, Chayanne Araujo, MD1, Ana Carla Moura, Alava1, Inmaculada Sanchez-Machin, MD PhD1, Hospital Univer- MD2, Dayanne Bruscky, MD2, Ana Caroline Dela Bianca, MD sitario de Canarias, Tenerife, Spain1 PhD2,In^es Camelo-Nunes1, Luis Felipe Ensina, MD, PhD1, Fed- 089 Efficacy and Safety of Crisaborole in Patients With Mild-to- eral University of S~ao Paulo (UNIFESP)1, Federal University of Moderate Atopic Dermatitis With Comorbid Allergic Rhinitis Pernambuco (UFPE)2 or Asthma 079 Omalizumab Treatment and Outcomes in Chinese Patients Jonathan Spergel, MD, PhD1, Michael Blaiss, MD FAAAAI2, with Chronic Spontaneous Urticaria, Chronic Inducible Urti- Peter Lio, MD3, Aharon Kessel, MD4, Liza Takiya, PharmD5, caria, or Both John Werth, PhD5, Michael O’Connell, MD5, Chuanbo Zang, Yudi Chen1, Yu Miao2, Ping Tu2, Marcus Maurer, MD3, PhD5, Michael Cork6, Children’s Hosp of Philadelphia, Perelman Zuotao Zhao, MD PhD4, Beijing Hospital1, Peking University School of Med at Univ of Pennsylvania, Philadelphia, PA1, Med- First Hospital2, Charite-Universitatsmedizin Berlin3, Peking ical College of Georgia at Augusta University, Augusta, GA2, University4 Northwestern University Feinberg School of Medicine, Chicago, 080 Clinical conditions of patients with chronic urticaria during IL3, Bnai Zion Medical Center, Haifa, Israel4, Pfizer Inc., College- the pandemic caused by the 2019 Novel Coronavirus Disease ville, PA5, Sheffield Dermatology Research, IICD, University of (COVID-19) Sheffield, Sheffield, UK6 Paula Argolo1, Grazielly Pereira2, Pereira GF1, Jorge Kalil, MD, 090 Therapeutic Potential of Rlip Loss on Atopic Dermatitis PhD1, Antonio Motta1, Rosana Agondi, MD PhD1, University of Malvika Ramesh, MD Candidate 20231, James Tarbox, MD1, S~ao Paulo1, Hospital das Clı´nicas, FMUSP, Sa˜o Paulo, Brazil2 Sanjay Awasthi, MD2, Sharda Singh, PhD2, Texas Tech University 081 Omalizumab in Children and Adolescents with Chronic Urti- Health Sciences Ce1, Texas Tech University Health Sciences caria: A 16 Week Real-World Study Center2 Xiaoting Song1, Marcus Maurer, MD2, Yudi Chen3, Miao Yu, 091 Lipid Profiles in Eczema Herpeticum and Eczema Vaccinatum MS4, Zuotao Zhao, MD PhD4, Peking University First Hospital1, Reflect Changes that Predispose to Disseminated Viral Infec- Charite-Universitatsmedizin Berlin2, Beijing Hospital3, Peking tion University4 Evgeny Berdyshev, PhD1, Elena Goleva, PhD1, Irina Bronova, 082 Cobalamin Deficiency and the Presence of Gastrointestinal PhD1, Patricia Taylor, NP1, Anna Sofia Bronoff1, Jon Hanifin, Symptoms in Patients with Chronic Urticaria MD FAAAAI2, Mark Slifka3, Donald Leung, MD PhD FAAAAI1, Sari Herman, MD, FRCPC1, Armin Abadeh, MD1, University of National Jewish Health1, Oregon Health & Science University2, Toronto1 Oregon Health & Science Univ3 083 Omalizumab in Chronic Inducible Urticaria: a Real-Life 092 Temperature changes contribute to skin barrier dysfunction: Study of Efficacy, Safety, Predictors of Treatment Outcome, potential implications for atopic dermatitis and food allergy Time to Response and Relapse Jessica Hui, MD1, Byung Kim, MD PhD1, Taras Lyubchenko, Miao Yu, MS1, Marcus Maurer, MD2, Yudi Chen3, Zuotao Zhao, PhD2, Elena Goleva, PhD1, Donald Leung, MD PhD FAAAAI1, MD PhD1, Peking University1, Charite-Universitatsmedizin Ber- National Jewish Health1, National Jewish Healh2 lin2, Beijing Hospital3 093 IgG4-Related Disease (IgG4-RD) With Unique Combined Skin 084 Increased Prevalence of Autoimmune Diseases in Children And Biliary Tract Manifestation with Chronic Spontaneous Urticaria Yela Jung1, Tejal Narsai, MD1, Ashley Sandoval, MD1, Sudhir Michelle Le, MD1, Lydia Zhang, MD1, Sofianne Gabrielli, MSc1, Gupta, MD PhD FAAAAI2, UC Irvine1, University of California Elena Netchiporouk, MD, MSc1, Sharon Baum2, Shoshana Green- at Irvine2 berger, Dermatology2, Luis Felipe Ensina, MD, PhD3, Fatemeh 094 Clinical characterization of skin pain in children with atopic Jafarian, MD1, Xun Zhang, PhD1, Moshe Ben-Shoshan, MD dermatitis FAAAAI1, McGill University Health Centre1, Chaim Sheba Med- Brian Cheng1, Amy Paller, MD1, James Griffith, PhD1, Jonathan ical Center2, Federal University of S~ao Paulo3 Silverberg2, Anna Fishbein, MD MS3, Northwestern University 085 Up-dosing to 600mg Omalizumab for Chronic Spontaneous Feinberg School of Medicine1, The George Washington Univer- Urticaria: Is it More Effective Than 300mg? sity School of Medicine and Health Sciences2, Ann & Robert Rachel Simpson1, Ariba Quidwai2, Jason Lee, MD FAAAAI1, H. Lurie Children’s Hospital of Chicago, Northwestern University Toronto Allergists1, Western University, London, On, Canada2 Feinberg School of Medicine3 J ALLERGY CLIN IMMUNOL Abstracts AB181 VOLUME 147, NUMBER 2

095 The role of metal patch testing in evaluating for metallic pros- 104 Patch Testing Outcomes in Patients Referred for Surgical Metal thetic joint failure Allergy Concern Levi Keller1, Alan Schocket1, Craig Hogan, MD1, University of Kristy Semenza1, Muhammad Pasha, MD FAAAAI1, Albany Med- Colorado1 ical College1 096 Single-cell immunopathology of systemic contact allergy associ- 105 Pruritus, Sleep, and Productivity: A Post Hoc Analysis of Abro- ated with corticosteroids. citinib Versus Placebo in Patients With Moderate-to-Severe Rebecca Hertzman1, Pooja Deshpande1, Katie White2, Rama Atopic Dermatitis (AD) From JADE MONO-2 Gangula2, Abha Chopra1, Ramesh Ram1, Shay Leary1, John Zic2, Gil Yosipovitch, MD1, Luz Fonacier, MD FAAAAI2, Sonja Jeffrey Zwerner2, Andrew Gibson1, Elizabeth Phillips, MD St€ander3, John Su4, Melinda Gooderham5, Jacek Szepietowski6, FAAAAI FIDSA3, Institute for Immunology and Infectious Dis- Mette Deleuran7, Giampiero Girolomoni8, Pinaki Biswas9, Claire ease, Murdoch University, Western Australia1, Vanderbilt Univer- Feeney10, Hernan Valdez9, Ricardo Rojo9, Andrew Thorpe9, Gary sity Medical Center, Nashville, TN, USA2, Vanderbilt University Chan9, Joseph Cappelleri9, Marco DiBonaventura9, Daniela Medical Center, Nashville, TN, USA,3 Myers9, Miami Itch Center1, NYU Winthrop Hospital2, Center for 097 Children With Atopic Dermatitis (AD) Have a High Burden of Chronic Pruritus, University of Muenster3, Murdoch Children’s Re- Atopic Comorbidities: Results From a Large Worldwide search Institute, Royal Children’s Hospital, University of Mel- Survey bourne4, SKiN Centre for Dermatology5, Wroclaw Medical Jonathan Silverberg1, Eric Simpson, MD MCR2, Stephan Wei- University6, Aarhus University Hospital7, Universita di Verona8, dinger, MD PhD3,Sebastien Barbarot4, Lysel Brignoli5, Tarek Pfizer Inc.9, Pfizer Ltd.10 Mnif5, Grece Saba5, Laurent Eckert, PhD6, Ana Rossi7, Dimittri 106 Depth and Rapidity of Response With Abrocitinib and Dupilu- Delevry8, Puneet Mahajan7, Northwestern University1, Oregon mab in Patients With Moderate-to-Severe Atopic Dermatitis Health & Science University2, University Hospital (AD) in JADE COMPARE Schleswig-Holstein3, Nantes University Hospital4, Kantar Health Peter Lio, MD1, Mark Boguniewicz, MD FAAAAI2, Andrew Division5, Sanofi6, Sanofi Genzyme7, Regeneron Pharmaceuticals, Alexis3, Mark Lebwohl4, Kristian Reich5, Andrew Pink6, Kenji Ka- Inc.8 bashima, MD PhD7, Robert Bissonnette8, Roman Nowicki9, Hernan 098 Real-World Effectiveness of Systemic Therapies for Atopic Der- Valdez10, Fan Zhang10, Marco DiBonaventura10, Claire Clibborn11, matitis (AD) in the United States: Analysis of a Retrospective Michael Cameron10, Northwestern University Feinberg School of Claims Database Medicine1, National Jewish Health and University of Colorado Marco DiBonaventura1, Marie-Helene Lafeuille2, Bruno Emond2, School of Medicine2, Mount Sinai Morningside and Mount Sinai Mei Sheng Duh2, Iman Fakih2, Natalie Yin1, Daniela Myers1, Claire West3, Icahn School of Medicine at Mount Sinai4, University Med- Feeney3, Joseph Cappelleri1, Jashin Wu4, Pfizer Inc.1, Analysis ical Center Hamburg-Eppendorf5, King’s College London6, Kyoto Group2, Pfizer Ltd.3, Dermatology Research and Education University Graduate School of Medicine7, Innovaderm Research Foundation4 Inc.8, Medical University of Gdansk 9, Pfizer Inc.10, Pfizer Ltd.11 099 Dupilumab Improves Signs And Symptoms Of Severe Atopic 107 Prednisolone Treatment Reduces Type 2 Inflammation In Skin Dermatitis In Children Aged 6–11 Years With And Without Co- Lesions Of Patients With Atopic Dermatitis morbid Asthma Emma Price1, Christiane Whetstone1, Dhuha Al-Sajee, MD, PhD1, Mark Boguniewicz, MD FAAAAI1, Lawrence Sher2, Amy Paller, Sai Sakktee Krisna, MSc1, Karen Howie1, Caroline Munoz1, Paul MD3, Elaine Siegfried, MD4, Zhen Chen, PhD5, Randy Prescilla, O’Byrne, MD1, Hermenio Lima, MD, PhD1, Roma Sehmi, PhD1, MD6, Brad Shumel, MD5, National Jewish Health, Denver, CO, Gail Gauvreau1, McMaster University1 USA1, Peninsula Research Associates, Rolling Hills Estates, CA, 108 Disease Characteristics and Burden in Patients With Atopic USA2, Northwestern University Feinberg School of Medicine, Chi- Dermatitis: Insights From Two Phase 3 Studies of Ruxolitinib cago, IL, USA3, Saint Louis University and Cardinal Glennon Chil- Cream dren’s Hospital, St. Louis, MO, USA4, Regeneron Pharmaceuticals, Eric Simpson, MD MCR1, Mark Lee, MD2, Kanwaljit Brar, MD3, Inc., Tarrytown, NY, USA5, Sanofi Genzyme, Cambridge, MA, Michael Kuligowski, MD, PhD, MBA4, May Venturanza, MD5, USA6 Kang Sun, PhD4, Darryl Toth, MD6, Oregon Health and Science 100 Real Time Assessment of Steroid Use in Patients with Atopic University, Portland, OR1, Progressive Clinical Research, San An- Dermatitis tonio, TX2, New York University Grossman School of Medicine, Sonam Sani, MD1, Stephanie Mawhirt, DO2, Erin Banta, MD3, Hassenfeld Children’s Hospital, New York, NY3, Incyte Corpora- Amanda Schneider, MD4, Luz Fonacier, MD FAAAAI3, Winthrop tion, Wilmington, DE4, Incyte Corporation Wilmington, DE5, University Hospital1, New York University-Winthrop Hospital2, XLR8 Medical Research and Probity Medical Research, Windsor, NYU Winthrop Hospital3, NYU4 ON, Canada6 101 Ruxolitinib Cream Ameliorates Itch and Inflammation in Pre- 109 House Dust Mite Sensitization is Associated with Resistance to clinical Models of Dermatitis Topical Therapy in Patients with Contact Dermatitis Monika Scuron, PhD1, Brittany Fay, BSc1, Andrew Connell, Oleksandr Litus, MD1, Yuriy Bisyuk, MD1, Viktor Litus1, Law- MSc1, Michael Peel, PhD1, Paul Smith, PhD1, Incyte Corporation1 rence Dubuske, MD FAAAAI2, Shupyk National Medical Academy 102 Protease-Activated Receptor-2: investigating role in regulation of Postgraduate Education, Kyiv, Ukraine1, George Washington of epidermal barrier and inflammation in Atopic Dermatitis University School of Medicine, Washington, DC, USA; Immunol- based on skin type. ogy Research Institute of New England, Gardner, MA, USA2 Shivani Doshi1, Peter Nadeau1, Anna De Benedetto, MD1, Univer- 110 The Effect Of Prednisolone Treatment On Histopathological sity of Florida1 Outcomes In Skin Of Patients With Atopic Dermatitis 103 Clinical And Epidemiological Profile Of Atopic Dermatitis (AD) Christiane Whetstone1, Nadia Alsaji, MD1, Emma Price1, Ruth In A Reference Center In An Emerging Country Cusack, MD1, Roma Sehmi, PhD1, Hermenio Lima, MD, PhD1, Fernanda Vaz, MD1, Raissa Roque, MD1, Marilia Moraes, MD1, Gail Gauvreau1, McMaster University1 Lara Teixeira1, Nathalia Vital, MD2, Caroline Ferreira, MD1, Rafael 111 Eczema Education Program improves pediatric atopic dermati- Saldanha1, Pedro Bubach1, Danielle Harari, MD1, Carolina Ara- tis control and family quality of life nda1, Marcia Mallozi, PhD2, Dirceu Sole, MD PhD FAAAAI3, Fed- Thomas Rawliuk1, Shannon Deane2, Shauna Filuk2, Jo-Anne St. eral University of S~ao Paulo1, Federal University of Sao Paulo2, Vincent2, Allan Becker, MD FAAAAI2, Elinor Simons, MD PhD Universidade Federal de Sao Paulo3 MS FAAAAI2, Children’s Hospital Research Institute of AB182 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2021

Manitoba1, University of Manitoba and Children’s Asthma & Al- National Academy of Sciences of Belarus, Minsk1, Belarusian State lergy Education Centre (CAAEC)2 Medical University, Minsk, Belarus2, George Washington Univer- 112 Atopic Dermatitis Phenotypes Impact Expression of Atopic Dis- sity School of Medicine, Washington, DC, USA; Immunology Re- eases Despite Similar Mononuclear Cell Cytokine Responses search Institute of New England, Gardner, MA, USA3 Mohamed Taki, MD MS1, Kristine Lee, MS1, James Gern, MD2, 120 Blood Dendritic Cells, Monocytes and Myeloid-derived Sup- Rob Lemanske, MD FAAAAI3, Dan Jackson, MD FAAAAI2, Anne pressor Cells in Patients with COVID-19 Associated Pneumonia Marie Singh, MD4, University of Wisconsin - Madison1, University Andrei Hancharou1, Alena Rynda1, Yana Minich1, Natalia Anto- of Wisconsin-Madison2, University of Wisconsin School of Medi- nevich1, Oxana Timohina1, Alena Halavach1, Darya Babrukevich1, cine and Public Health3, University of Wisconsin4 Marina Dotsenko2, Eduard Dotsenko2, Lawrence Dubuske, MD FAAAAI3, The Institute of Biophysics and Cell Engineering of Na- tional Academy of Sciences of Belarus, Minsk1, Belarusian State Medical University, Minsk, Belarus2, George Washington Univer- Asthma and Airway Immunology sity School of Medicine, Washington, DC, USA; Immunology Re- 113 Effects of Dexamethasone on airway epithelial cells exposed to search Institute of New England, Gardner, MA, USA3 oxidative stress Chioma Enweasor, MD1, Duane Kim, Medical Student1, Cameron Flayer, PhD1, Angela Linderholm, PhD1, Lisa Franzi1, Angela Haczku, MD PhD FAAAAI1, UC Davis1 Asthma Diagnosis and Therapy 114 Airway Epithelial Gene Expression Differs Across Urban 121 Assessing Systemic Symptoms During Aspirin Challenge in As- Childhood Asthma Phenotypes pirin Exacerbated Respiratory Disease (AERD) 1 2 Matthew Altman, MD , Edward Zoratti, MD FAAAAI , Andrew Patrick Staso1, Pingsheng Wu2, Tanya Laidlaw, MD FAAAAI3, 3 4 Liu, MD FAAAAI , Jacqueline Pongracic, MD FAAAAI , Jessica Katherine Cahill, MD1, Vanderbilt University Medical Center1, 5 6 Gereige, MD , Robert Wood, MD , Gurjit Khurana Hershey, MD Vanderbilt University School of Medicine2, Harvard Medical 7 7 PhD FAAAAI , Carolyn Kercsmar, MD , Rebecca Gruchalla, MD School3 8 9 10 PhD FAAAAI , Meyer Kattan, MD , Stephen Teach, MD , Alyssa 122 Expert Advice on Managing Severe Asthma: An Interactive De- 11 12 Ylescupidez, PhD , Steve Sigelman, BSN , Peter Gergen, MD cision Support Tool Provides Real-Time Expert Recommenda- 12 13 14 MPH , Alkis Togias, MD FAAAAI , Cynthia Visness, PhD , tions 11 15 Scott Presnell, PhD , James Gern, MD , William Busse, MD Zachary Schwartz1, Carolyn Skowronski, PharmD1, Anne Roc, 16 15 FAAAAI , Dan Jackson, MD FAAAAI , University of Washing- PhD1, Bradley Chipps, MD FAAAAI2, Nicola Hanania, MD, 1 2 3 ton , Henry Ford Hospital , Children’s Hospital Colorado , Ann & MS3, Linda Rogers4, Eileen Wang, MD5, Michael Wechsler, 4 Robert H. Lurie Children , Boston Medical Center - Shapiro Cen- MD5, Clinical Care Options1, Capital Allergy and Respiratory 5 6 ter , Johns Hopkins University School Medicine , Cincinnati Chil- Dis. Ctr2, Baylor College of Medicine3, Mount Sinai4, National 7 dren’s Hospital Medical Center , Univ. Texas Southwestern Jewish Health5 8 9 Medical Center , Columbia University Medical Center , Children’s 123 Fraction of exhaled nitric oxide measured by NO breathÒ cor- 10 11 12 National Hospital , Benaroya Research Institute , NIH/NIAID , relate with airway hyperreactivity 13 14 15 NIAID/NIH , Rho, Inc. , University of Wisconsin-Madison , Yosuke Kamide, MD PhD1, Hiroaki Hayashi, MD1, Yuto Ham- 16 University of Wisconsin School of Medici ada1, Kiyoshi Sekiya1, Akio Mori, MD PhD1, Masami Taniguchi, 115 HuR-targeted Inhibition Impairs Th2 Proinflammatory Re- MD, PhD2, Sagamihara National Hospital1, Shonan Kamakura sponses in Asthmatic CD4+ T cells General Hospital2 1 1 1 Fatemeh Fattahi , Jason Ellis , Michael Sylveste , Kristin Ba- 124 COVID-19, severe asthma and biologicals targeting type 2 in- 1 1 1 2 helda , Samuel Hietanen , Luis Correa , Njira Lugogo, MD , flammation: results in a third-level hospital in Madrid, Spain. 3 Ulus Atasoy , Department of Internal Medicine, Division of Al- Alicia Domınguez Estirado1, Gabriela Zambrano Ibarra, MD1, lergy & Clinical Immunology, University of Michigan Medical Filip Skrabski, Allergologist1, Francisco Javier De Castro Martınez, 1 School, Ann Arbor, MI , Division of Pulmonary and Critical Care MD1, Julia De Pedro, MD1, Maria Pilar Sanz Sanz, MD1, Jose Zu- 2 Medicine, University of Michigan, Ann Arbor, MI , 1.Department beldia, MD1, Elena Rodriguez, MD1, Hospital General Universi- of Internal Medicine, Division of Allergy & Clinical Immunology, tario Gregorio Maran~on 1 University of Michigan Medical School, 2.Division of Allergy-Im- 125 Use of Impulse Oscillometry to Detect Vocal Cord Dysfunction 3 munology, Ann Arbor VA Health System, Ann Arbor, MI Julia Smith1, Alyssa Osheim1, Greater Austin Allergy, Asthma and 116 Detergent Induces Active Release of IL-33 from Airway Epithe- Immunology1 lial Cells and Promotes Innate Type 2 Response in the Lungs 126 Combined assessment of serum periostin, YKL-40, and bron- 1 2 3 Kenzo Ohara , Koji Iijima, PhD , S.M. O’Grady , Hirohito Kita, chial hyperresponsiveness in asthmatic children 2 1 MD , Mayo Clinic Arizona, Asahikawa Medical University , Heysung Baek, MD1, Junhong Park2, HaYoung Won3, Hallym 2 3 Mayo Clinic Arizona , University of Minnesota University Kangdong1, Hallym University Kandong Sacred Heart 117 Estrogen Decreases The Expression Of Tmem178 In Differenti- Hospital2, Kangdong Sacred Heart Hospital, Hallym University ated Airway Epithelium College of Medicine3 Kimberly Stelzig1, Y. Prakash, MD, PhD1, Mayo Clinic1 118 Comparison of CyTOF analysis with cytospin for sputum cell differential Janette Birmingham1, Juan Wisnivesky1, Alex Federman1, Jona- Asthma Epidemiology, Intervention, and Public than Federman2, Adeeb Rahman1, Brian Lee1, Icahn School of Medicine at Mount Sinai1, Yeshiva University2 Health 119 Immune Predictors of Death versus Survival in COVID-19 ICU 127 A National Survey of Asthma Specialist Perspectives on Physi- Pneumonia Patients on Mechanical Ventilators cal Activity in Asthma Natalia Antonevich1, Andrei Hancharou1, Alena Rynda1, Marina Basil Kahwash, MD1, Karen Gregory, DNP APRN-BC RRT AE- Dotsenko2, Eduard Dotsenko2, Alena Halavach1, Oxana Timohina1, C2, Lisa Sharp, PhD3, Sharmilee Nyenhuis, MD FAAAAI3, Vander- Yana Minich1, Darya Babrukevich1, Lawrence Dubuske, MD bilt University1, Oklahoma Allergy and Asthma Clinic2, University FAAAAI3, The Institute of Biophysics and Cell Engineering of of Illinois at Chicago3 J ALLERGY CLIN IMMUNOL Abstracts AB183 VOLUME 147, NUMBER 2

128 Asthma care provider perspectives on exercise promotion in University Hospital, Chonnam National University Medical people with asthma: an examination of knowledge, practices, School,4, Pusan National University Yangsan Hospital5, Hallym barriers, and facilitators University Sacred Heart Hospital, Hallym University College of Sharmilee Nyenhuis, MD FAAAAI1, Karen Gregory, DNP APRN- Medicine6 BC RRT AE-C2, Basil Kahwash, MD3, Lisa Sharp, PhD1, Univer- 138 Asthma as a predictor of more severe outcomes in COVID-19 sity of Illinois at Chicago1, Oklahoma Allergy and Asthma Clinic2, infection Ohio State3 Lauren Eggert1, Shu Cao1, Ziyuan He2, Gopal Krishna Dhondalay, 129 Relationship of Rhinitis and Respiratory Allergy and Asthma PhD3, Shirley Jiang1, William Collins, MD4, Sayantani Sindher, Phenotypes in an Urban Birth Cohort MD1, Kari Nadeau, MD PhD FAAAAI5, R. Sharon Chinthrajah, Sima Ramratnam, MD MPH1, Agustin Calatroni, MA MS2, Leo- MD1, Stanford University School of Medicine1, Stanford Univer- nard Bacharier, MD FAAAAI3, Meyer Kattan, MD4, George O, sity2, Sean N Parker Centre for Allergy & Asthm3, Stanford4, Stan- MD5, Robert Wood, MD6, Cynthia Visness, PhD7, Dan Jackson, ford Univ School Medicine5 MD FAAAAI8, James Gern, MD8, University of Madison Wiscon- 139 A study on Bone mineral density among asthmatic children on in- sin1, Rho Federal Systems Division, inc.2, Washington University3, haled corticosteroids attending a tertiary care hospital at Mysuru. Columbia University Medical Center4, Boston University School of Thanuja B1,SavithaRamaraj2, Mysore Medical College and Re- Medicine5, Johns Hopkins University School Medicine6, Rho, Inc.7, search Institute1, Mysore Medical College2 University of Wisconsin-Madison8 130 Association Between Exposure to Outdoor Air Pollution and School Absenteeism Among Asthmatic Children Asthma Epidemiology, Risk Factors, and Tricia Morphew1, John Graham, PhD2, Kara Rubio, MPH3, Nor- man Anderson, MSPH4, Deborah Gentile, MD5, Morphew Consul- Outcomes ting, LLC1, Clean Air Task Force, Boston, MA2, Women for a 140 Outdoor Allergies are Associated with Increased Oral Cortico- Healthy Environment3, Anderson Environmental Health4, Commu- steroid Use in Children with Allergic Asthma in New York City: nity Partners in Asthma Care5 A Single-Center Retrospective Study 131 Analysis of Serum Allergen Screening Results of 2061 Patients Angela Chan, MD1, NYP Hospital- Columbia1 with asthma in Taiyuan Area 141 Associated factors with recurrent wheezing in infants: is there Kathy Kong1, Yangyang Wei1, JING Ma2, Xiaojing Wang1, The difference between the genders? First Hospital of Shanxi Medical University1, Shanxi Cardiovascu- Herberto Chong Neto1, Wellington Ferreira2, Gustavo Wandalsen, lar Hospital2 MD3, Dirceu Sole3, Emanuel Sarinho4,Decio Medeiros5, Elaine 132 Assessing Asthma Control By Frequency Of High Systemic Prestes6, Paulo Camargos7, Nelson Rosario, MD PhD FAAAAI8, Corticosteroid And/or SABA Prescriptions In US Administra- Universidade Federal do Parana1, Federal University of Parana2, tive Claims Data Federal University of S~ao Paulo-EPM3, University Federal of Per- Marko Mychaskiw, BSRPh, MS, PhD1, Sangtaeck Lim, MPH1, nambuco, Brazil4, Federal University of Pernambuco5, Para State Susan Colilla, PhD, MPH1, Randall Brown1, Teva Branded Pharma- University6, Federal University of Minas Gerais7, Federal Univer- ceutical Products R&D Inc., West Chester, PA, USA1 sity of ParanA~¡8 133 Comorbidities in Asthma: Not a Numbers Game 142 Early life food allergen sensitization and risk of childhood Jonwei Hwang1, A Reddy, BS1, Sharmilee Nyenhuis, MD asthma in an infant bronchiolitis cohort FAAAAI1, University of Illinois at Chicago1 Anna Arroyo, MD MPH1, Lacey Robinson, MD2, Ruth Geller, 134 Asthma care during the COVID-19 pandemic: Differences in at- MHS3, Susan Rudders, MD MS4, Jonathan Spergel, MD, PhD5, titudes and expectations between physicians and patients Cindy Bauer6, Ashley Sullivan, MPH MS3, Kohei Hasegawa, MD Nonie Arora, MD, MBA1, Desmond Lowe, BS2, Nadeen Sarsour, MPH2, Carlos Camargo Jr., MD DrPH2, Stanford School of Medi- BS2, Hannah Jaffee, MS3, Sanaz Eftekhari, BA3, Laurie Carpenter, cine1, Harvard Medical School, Massachusetts General Hospital2, MSW4, Priya Bansal, MD FAAAAI5, Alan Baptist, MD MPH Massachusetts General Hospital3, Harvard Medical School, Boston FAAAAI4, University of Michigan, Internal Medicine1, University Children’s Hospital4, Children’s Hospital of Philadelphia5, Phoenix of Michigan Medical School2, Asthma and Allergy Foundation of Children’s Hospital6 America (AAFA)3, University of Michigan, Division of Allergy 143 Association Between Olfactory Function and Asthma In Adults and Clinical Immunology4, Asthma and Allergy Wellness Center5 Hyo-In Rhyou1, Woo-Yong Bae1, Young-Hee Nam, MD1, College 135 Infant rhinorrhea and watery eyes and adolescent Attention of Medicine, Dong-A University, Busan, Korea1 Deficit Hyperactivity Disorder. 144 Do Airborne Mold Counts Predict Asthma Exacerbations? Matthew Perzanowski, PhD1, Virginia Rauh, ScD1, Bruce Ram- Kelsey Kaman, MD1, Christopher Randolph, MD FAAAAI2, Yale phal1, Luis Acosta, MD1, Lori Hoepner2, Frederica Perera, PhD3, University1, Center for Allergy, Asthma & Immunology2 Julie Herbstman, PhD1, Rachel Miller, MD FAAAAI4, Amy Marg- 145 Pediatric Severe Asthmatics in a Southern US State Face Mul- olis1, Columbia University1, SUNY Downstate2, Columbia Center tiple Challenges and Barriers to Care for Children3, Icahn School of Medicine at Mount Sinai4 Robbie Pesek, MD1, Brandi Whitaker, PhD2, Erhan Ararat, MD2, 136 Physical Distancing –A Role in Keeping Viral-Induced Asthma Amika Sood, MD3, Matthew Pertzborn, MD2, Amber Davidson, at Arm’s Length? MSW4, Kim Cobb, MA, RRT-AE-C4, Kristin Hines, BS, Catherine Freeman, MBBch BAO MRCPI1, Matthew Rank, MD RRT,AE-C, CPFT4, Callie Margiotta3, Jessica Turner, allied FAAAAI2, Thomas Grys, PhD1, Catherine Bolster, MT1, John health5, Akilah Jefferson6, Tamara Perry, MD FAAAAI7, University Lewis, MD1, Mayo Clinic Arizona1, Mayo Clinic and Foundation2 of Arkansas for Medical Sciences1, University of Arkansas for 137 Different childhood asthma phenotypes based on humidifier dis- Medical Sciences and Arkansas Children’s Hospital2, Arkansas infectant exposure Children3, Arkansas Children’s Hospital4, University of Arkansas So-Yeon Lee, MD PhD1, Mi-Jin Kang2, Min Jee Park1, Hyun-ju for Medical Scien5, UC San Diego6, UAMS/Arkansas Children7 Cho3, Eun Lee, PhD4, Sungsu Jung5, Song-I Yang6, Soo-Jong 146 Clinical and Economic Burden of Patients with Uncontrolled Hong, MD FAAAAI1, Asan Medical Center, University of Ulsan Severe Asthma with Low Blood Eosinophil Levels in the United College of Medicine1, Humidifier Disinfectant Health Center, States Asan Medical Center2, International St. Mary’s hospital, Catholic Laren Tan1, Joan Reibman2, Chris Ambrose, MD MBA3,Yen Kwandong University College of Medicine3, Chonnam National Chung, pharmd3, Pooja Desai4, Jean-Pierre Llanos Ackert4, AB184 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2021

Meghan Moynihan5, Joseph Tkacz, MS5, Loma Linda University Colorado, University of Colorado School of Medicine3, Propeller Medical Center1, New York University School of Medicine2, Astra- Health4 Zeneca3, Amgen4, IBM Watson Health5 155 Utilizing the ASTHMAXcel PRO Mobile Platform to Conduct a 147 Effects of Sex and Age on Characteristics of United States Pa- Virtual Cohort Study During the COVID-19 Pandemic tients With Severe Asthma Emine Cosar, Savneet Kaur1, Anjani Singh, MD2, Obumneme Njira Lugogo, MD1, Elizabeth Judson2, Erin Haight2, Frank Trudo, Njeze, BS1, Brian Hsia, MD3, Sunit Jariwala, MD FAAAAI4, Al- MD2, Bradley Chipps, MD FAAAAI3, Jennifer Trevor, MD4, Chris bert Einstein College of Medicine1, Albert Einstein College of Ambrose, MD MBA2, University of Michigan1, Astrazeneca2, Cap- Medicine/Mont2, Mount Sinai Hospital3, Albert Einstein/Monte- ital Allergy and Respiratory Dis. Ctr3, University of Alabama at fiore Medical Cente4 Birmingham4 156 Development of a Novel, Interactive, Electronic Pediatric 148 Baseline Asthma Impairment and Risk Questionnaire (AIRQä) Asthma Diary for Self-Report of Symptom Severity and Disease Control Level is Associated with Future Risk of Exacerbations Impact by Young Children With Asthma David Beuther1, Kevin Murphy, MD2, Robert Zeiger, MD PhD Marci Clark1, Carla Romano1, Oyebimpe Olayinka-Amao1, Diane FAAAAI3, Robert Wise4, William McCann, MD FAAAAI5, Joan Whalley1, Rebecca Crawford1, Purnima Pathak2, Caterina Brin- Reibman6, Maureen George, PhD RN AE-C7, Ileen Gilbert8, James dicci2, Kristin Garg2, Kattayoun Kordy2, Francois Everhard2, Fran- Eudicone8, Hitesh Ghandi8, Karin Coyne9, Melissa Ross9, Bradley cesco Patalano2, Zach Roesler3, Thomas Sutton3, Oskar Chipps10, National Jewish Health, Denver, CO1, Boys Town Na- Goransson3, Ross Landles3, Christel Naujoks2, Jessica Marvel2, tional Research Hospital, Boys Town, NE2, Departments of Allergy Dorothy Keininger2, RTI Health Solutions1, Novartis Pharma and Research and Evaluation, Kaiser Permanente Southern Califor- AG2, frog3 nia, San Diego and Pasadena, CA3, Division of Pulmonary and Crit- 157 Impact of a Digital Asthma Intervention on Short-acting Beta- ical Care Medicine, Johns Hopkins University School of Medicine, agonist (SABA) Medication Use Among Medicaid-enrolled Baltimore, MD4, Allergy Partners, Asheville, NC5, New York Uni- Children in Southwest Detroit versity School of Medicine, New York, NY6, Columbia University Meredith Barrett, PhD1, Rahul Gondalia, PhD1, Carolynn Row- School of Nursing, New York, NY7, AstraZeneca, Wilmington, land, RN2, Alex Hill, MA3, Elliot Attisha, MD4, Leanne Kaye1, DE8, Evidera, Bethesda, MD9, Capital Allergy & Respiratory Dis- Teresa Holtrop, MD5, Propeller (during work); ResMed (current)1, ease Center, Sacramento, CA10 Kids’ Health Connection2, Detroit Health Department (during 149 Perception of burden of oral and inhaled corticosteroid adverse work); Wayne State University (current)3, Detroit Public Schools effects by asthmatic patients Community District4, Kids’ Health Connections5 Vickram Tejwani1, Hsing-Yuan Chang, MD, MPH2, Annie Tran, 158 Are Caregivers Of Pediatric Patients With Asthma Willing To MPH2, Tonya Winders3, Rachael Moloney, MPH2, Johns Hopkins Use Telemedicine To Prevent Emergency Room Visits? University1, Center for Medical Technology Policy2, Allergy & Jully Padam1, BronxCare1 Asthma Network3 159 Phenotyping patients based on longitudinal heterogeneity of en- 150 Wheezing patterns in childhood and body mass index, blood gagement patterns with the ASTHMAXcel PRO mobile health pressure, and lung function in school-aged children application Catalina Acosta, Maribel Casas1, Judith Garcia2, Isglobal Institute Savneet Kaur, Emine Cosar1, Obumneme Njeze, BS2, Anjani of global health1, Isglobal, Insitutite of Global health2 Singh, MD3, Brian Hsia, MD4, Sunit Jariwala, MD FAAAAI5, 151 Analysis Of COVID-19 In Adult Asthmatic Outpatients Montefiore Medical Center1, Montefiore Medical Center/Albert Maria Somoza Alvarez, MD1, Ana MarAa~ Prieto-Moreno Pfeifer, Einstei2, Albert Einstein College of Medicine/Mont3, Mount Sinai CME1, Isabel Torres Rojas, CME1, Maria Desamparados Cervera1, Hospital4, Albert Einstein/Montefiore Medical Cente5 Diana Perez-Alzate1, Maria Vazquez de La Torre1, Elisa Haroun- Diaz1, Francisco Javier Ruano1, Paula Lopez-Gonzalez1, Natalia Blanca-Lopez1, Gabriela Canto, MD, PhD1, Infanta Leonor Univer- sity Hospital1 Asthma Pathogenesis and Inflammation 152 Relationships Between Dietary Flavonoid Intake, Gut Micro- 160 (1) DNA methylation biomarkers in nasal epithelium for severe biota, And Asthma Clinical Features asthma in children Michelle El-Hosni1, Ariangela Kozik, PhD1, Molly Cook, Re- Tao Zhu1, Xue Zhang, PhD2, Xiaoting Chen, PhD2, Anthony search Lab Tech1, Alan Baptist, MD MPH FAAAAI1, Nicole Scha- Brown1, Matthew Weirauch, PhD2, Theresa Guilbert, MD, MS3, fer1, Clinical Research Coordinator1, Lesa Begley, MS1, Yvonne Gurjit Khurana Hershey, MD PhD FAAAAI2, Jocelyn Biagini Huang, MD1, University of Michigan1 Myers, PhD3, California National Primate Research Center, Univer- sity of California Davis1, Cincinnati Children’s Hospital Medical Center2, Cincinnati Children3 161 Upper Airway Microbiota Relates to Season and Asthma Exac- Asthma Management with Technologies erbations 153 The ASTHMAXcel PRO Mobile Application for Adult Patients: Kathryn McCauley1, Kaitlin Flynn, PhD2, Vincent DiMassa, Evaluating User Satisfaction and Adoption MPH1, Douglas Fadrosh1, Kole Lynch1, Petra LeBeau, ScD3, Agus- Anjani Singh, MD1, Obumneme Njeze, BS2, Emine Cosar1, Sav- tin Calatroni, MA MS4, Brett Jepson3, Michelle Gill, MD PhD5, neet Kaur1, Brian Hsia, MD3, Sunit Jariwala, MD FAAAAI4, Albert James Gern, MD6, Dan Jackson, MD FAAAAI6, Matthew Altman, Einstein College of Medicine/Montefiore Medical Center1, Monte- MD7, Susan Lynch, PhD8, University of California, San Francisco1, fiore Medical Center/Albert Einstei2, Mount Sinai Hospital3, Albert Benaroya Research Institute2, Rho, Inc.3, Rho Federal Systems Di- Einstein/Montefiore Medical Cente4 vision, inc.4, UT Southwestern Medical Center at Dallas5, Univer- 154 Medication adherence was greater in a digital asthma platform sity of Wisconsin-Madison6, University of Washington7, Asthma, consisting of controller and rescue vs. controller inhalers alone Immunology & Allergy Assoc8 Rahul Gondalia, PhD1, William Anderson, MD FAAAAI2, 162 Endogenous hydrogen sulfide is directly correlated with age and Leanne Kaye1, Heather De Keyser, MD3, Meredith Barrett, PhD1, inversely correlated with intensive care length of stay in chil- Stanley Szefler, MD FAAAAI3, David Stempel, MD FAAAAI4, Re- dren with respiratory syncytial virus (RSV) bronchiolitis. sMed1, Children’s Hospital Colorado, University of Colorado Jose Rojas-Camayo1, Nadiya Druzhyna1, Antonella Casola1, Rob- School of Medicine2, Breathing Institute, Children’s Hospital erto Garofalo1, University of Texas Medical Branch1 J ALLERGY CLIN IMMUNOL Abstracts AB185 VOLUME 147, NUMBER 2

163 Association of the Gut Microbiome and Metabolome with 169 (1) Associations of PAI-1 Promoter Polymorphism and African Wheeze Frequency in Childhood Asthma Ancestry with Asthma in the GALA2 cohort Kathleen Lee-Sarwar1, Sandra Dedrick2, Babak Momeni2, Rachel Joong Cho1, Angel Mak, PhD2, Donglei Hu, PhD2, Sam Oh, PhD Kelly1, Robert Zeiger, MD PhD FAAAAI3, George O’Connor4, MPH2, Scott Hunstman, MS2, Celeste Eng, BS2, Harold Farber, Megan Sandel5, Leonard Bacharier, MD FAAAAI6, Avraham Bei- MD, MSPH3, William Rodriguez-Cintron, MD4, Denise Ser- gelman, MD MSCI FAAAAI6, Nancy Laranjo1, Diane Gold, MD1, ebrisky5, Shannon Thyne, MD6, Luisa Borrell, DDS, PhD, MPH7, Jessica Lasky-Su1, Augusto Litonjua, MD MPH7, Yang-Yu Liu1, Jose Rodriguez-Santana, MD8, L. Keoki Williams, MD MPH Scott Weiss, MD MS8, Channing Division of Network Medicine, FAAAAI9, Max Seibold, PhD10, Esteban Burchard, MD2, Rajesh Brigham and Women’s Hospital and Harvard Medical School, Bos- Kumar, MD FAAAAI11, Ann and Robert H. Lurie Children, Uni- ton, MA, USA1, Boston College, Department of Biology, Chestnut versity of Illinois College of Medicine1, University of California, Hill, MA, USA2, Departments of Allergy and Research and Evalu- San Francisco2, Texas Children3, Veterans Caribbean Health Care ation, Kaiser Permanente Southern California, San Diego and Pasa- System4, Jacobi Asthma and Allergy for Chi5, UCSF School of dena, CA, USA3, Pulmonary Center and Department of Medicine, Medicine6, Lehman College, City University of New York7, Centro Boston University School of Medicine, Boston, MA, USA4, Depart- de Neumologia Pediatrica8, Henry Ford Health System9, National ment of Pediatrics, Boston Medical Center, Boston, MA, USA5, Di- Jewish Health10, Ann & Robert H. Lurie Children11 vision of Pediatric Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medi- cine, St Louis, MO and St Louis Children’s Hospital, St Louis, MO, USA6, Division of Pediatric Pulmonary Medicine, Golisano Asthma Therapy Children’s Hospital at Strong, University of Rochester Medical 170 Real-World Rapid Response to Mepolizumab in the Uncon- Center, Rochester, NY, USA7, Channing Division of Network Med- trolled T2 Severe Asthma Endotype icine, Brigham and Women’s Hospital and Harvard Medical Ruperto Gonzalez Perez, MD PhD1, Paloma Poza-Guedes, MD, School, Boston, MA, USA8 PhD1, Elena Mederos-Luıs1, Victor Matheu-Delgado, MD, PhD1, 164 EEC exposure to mite in allergic asthma induces an increase of Cristina Alava-Cruz 1, Inmaculada Sanchez-Machın1, Hospital Uni- function and recruitment molecules on blood Treg. versitario de Canarias1 Virginie Doyen1, Anh Poirot2, Myriam Maumy-Bertrand3, Natha- 171 Steroid Stewardship – Survey Results & Awareness Strategies lie Domis4, Naji Khayath2, Francis Corazza5, Frederic De Blay6, Jackie Eghrari-Sabet1, Tonya Winders1, Allergy & Asthma Clinic of Immuno-Allergology, CHU-Brugmann, Brussels, Bel- Network1 gium; Translationnal Laboratory Research, ULB223, Universite Li- 172 Efficacy of Omalizumab against Aspirin-hypersensitivity and bre de Bruxelles, Brussels, Belgium1, Chest Diseases Department, Overproduction of Cysteinyl Leukotrienes in Aspirin-exacer- Strasbourg University Hospital, Strasbourg, France2, Advanced bated Respiratory Disease: A Randomized Trial Mathematics Research Institut (IRMA), Strasbourg, France3, Hiroaki Hayashi, MD1, Yuma Fukutomi, MD2, Chihiro Mitsui, ALYATECÒ Environmental Exposure Chamber, Strasbourg, MD2, Keiichi Kajiwara, BSc2, Kentaro Watai2, Yosuke Kamide, France4, Immunology Laboratory, CHU Brugmann, Brussels, Bel- MD PhD2, Maki Iwata, MD2, Kisako Nagayama2, Yuto Nakamura, gium;Translationnal Laboratory Research, ULB223, Universite Li- MD2, Yuto Hamada2, Yasuhiro Tomita, MD PhD1, Kiyoshi Sekiya2, bre de Bruxelles, Brussels, Belgium5, Chest Diseases Takahiro Tsuburai, MD PhD3, Akio Mori, MD PhD2, Kenji Izu- Department;Federation of translational medicine EA 3070;ALYA- hara4, Keiko Wakahara, MD PhD5, Naozumi Hashimoto, MD TECÒ, Strasbourg, France6 PhD5, Yoshinori Hasegawa, MD PhD5, Masami Taniguchi, MD, 165 CXCL1 Levels as a Biomarker of Systemic Inflammation in Se- PhD6, Clinical Research Center, National Hospital Organization Sa- vere Asthma gamihara National Hospital and Department of Respiratory Medi- Galyna Yeryomenko1, Tetyana Bezditko1, Lawrence Dubuske, cine, Nagoya University Graduate School of Medicine1, National MD FAAAAI2, Kharkiv National Medical University, Kharkiv, Uk- Hospital Organization Sagamihara National Hospital2, St. Marianna raine1, George Washington University School of Medicine, Wash- University School of Medicine3, Saga Medical School4, Nagoya ington, DC, USA; Immunology Research Institute of New University Graduate School of Medicine5, Clinical Research Cen- England, Gardner, MA, USA2 ter, National Hospital Organization Sagamihara National Hospital 166 Interleukin-26 is a Novel Biomarker for Asthma Inflammation and Shonan Kamakura General Hospital Center for Immunology Associated with Systemic Inflammation and Lung Function in and Allergology6 Obese Asthmatics 173 Managing Patients with Severe Asthma and Common Comor- Igor Kaidashev1, Yanina Avramenko1, Olga Izmailova1, Oksana bidities of Atopy, Obesity & Depression/Anxiety: Real-world Shlykova1, Lawrence Dubuske, MD FAAAAI2, Ukrainian Medical Effectiveness of Mepolizumab Stomatological Academy, Poltava, Ukraine1, George Washington Nestor Molfino, MD MSc1, Thomas Casale, MD FAAAAI2, Jared University School of Medicine, Washington, DC, USA; Silver, MD; PhD1, Michael Bogart, PharmD1, Elizabeth Packnett, Immunology Research Institute of New England, Gardner, MA, MPH3, Donna McMorrow, BS3, Juan Wu, ScD3, Beth Hahn1, Glax- USA2 oSmithKline1, University of South Florida2, IBM Watson Health3 167 Interleukin-13 as a Marker of Allergic Inflammation in Patients 174 Impact of baseline clinical asthma characteristics on the re- with Fungal Asthma sponse to mepolizumab: a post hoc meta-analysis of two Phase Tatyana Novikova1, Eduard Dotsenko1, Lawrence Dubuske, MD III trials FAAAAI2, Belorussian State Medical University, Minsk, Belarus1, Mark Liu, MD FAAAAI1, Camille Taille2, Jason Lee, MD George Washington University School of Medicine, Washington, FAAAAI3, Steven Smith, PhD MSc4, Steve Mallett, MSc5, Neil DC, USA; Immunology Research Institute of New England, Gard- Martin, MD6, Peter Howarth, MD6, Steven Yancey, MS MBA4, ner, MA, USA2 Catherine Lemiere, MD MSc7, Pulmonary and Critical Care Med- 168 Vagal sensory neurons sense allergens to regulate Type 2 in- icine, Johns Hopkins Asthma and Allergy Center, Baltimore, MD, flammation USA1,Hopital^ Bichat, AP-HP-Nord ; Universite de Paris ; F- Theo Crosson1, JO-CHIAO WANG2, Katiane Roversi3, Tuany CRIN CRISALIS, Paris, France2, Toronto Allergy and Asthma Eichwald3, Mohammad Balood3, Maryam Ahmadi3, Sebastien Tal- Clinic, Toronto, ON, Canada3, GSK, Research Triangle Park, NC, 3 ~ ~ 1 2 bot, PhD , UniversitAÓ de MontrAÓal , University of Montreal , USA4, GSK, Stockley Park, Uxbridge, Middlesex, UK5, GSK, Universite de Montreal3 Brentford, Middlesex, UK6, Universite de Montreal, Montreal, AB186 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2021

QC Canada ; Hopital^ du Sacre-Cœur de Montreal, Montreal, QC Tennessee Health Science Center1, University of Tennessee Health Canada7 Science Center/ Le Bonheur Children’s Hospital2, Tennessee Clin- 175 Treatment with Tezepelumab Reduces Serum Interleukin (IL)-5 ical and Translational Science Institute at University of TN Health and IL-13 in Patients with Severe, Uncontrolled Asthma to Science Center3, University of Tennessee Health Science Center/Le Levels Approaching those Observed in Healthy Individuals Bonheur Children’s Hospital4 Tuyet-Hang Pham1, Janet Griffiths, PhD1, Gene Colice, MD2, Jane 181 Corresponding doses of mometasone furoate (MF) in once-daily Parnes, MD3, Claudia Chen4, Bill Cook5, Translational Science and inhaled fixed-dose combination (FDC) of indacaterol/mometa- Experimental Medicine, Research and Early Development, Respira- sone furoate (IND/MF) and indacaterol/glycopyrronium/mome- tory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gai- tasone furoate (IND/GLY/MF): results from randomized thersburg, MD1, Late Respiratory & Immunology, clinical studies BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD2, Am- Roland Buhl1, Huib Kerstjens2, Ivan Nikolaev3, Soniya Vaidya4, gen, Thousand Oaks, CA3, Biometrics, Late Respiratory and Immu- Christian Bartels3, Monish Jain4, Juergen Jauernig3, Ioannis Kotta- nology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, kis3, Chenyu Qian5, Hanns-Christian Tillman6, Pulmonary Depart- MD4, Respiratory & Immunology, BioPharmaceuticals Medical, ment, Mainz University Hospital, Mainz, Germany1, University AstraZeneca, Gaithersburg, MD5 Medical Center Groningen, Groningen, The Netherlands2, Novartis 176 CAPTAIN: Effects of Body Mass Index (BMI) on Response to Pharma AG, Basel, Switzerland3, Novartis Institutes for Triple Therapy in Patients With Inadequately Controlled BioMedical Research, Cambridge, MA, USA4, Novartis Institutes Asthma on Inhaled Corticosteroids/Long-acting b2-agonists for BioMedical Research, Shanghai, China5, Novartis Institutes (ICS/LABA) for Biomedical Research Translational Medicine, Basel, Diego Maselli1, Sarah Chang, PhD2, Andrew Fowler3,MarkLiu, Switzerland6 MD FAAAAI4, Michael Manning5, David Mannino, MD2, 182 Pharmacokinetics Of Indacaterol/Glycopyrronium/Mometa- Joseph Spahn, MD6, Agne Zarankaite3, Edward Kerwin, MD sone Furoate In Healthy Chinese Volunteers: Results From A FAAAAI7, University of Texas Health at San Antonio, San Randomized, Open-Label, Parallel-Group Study Antonio, TX, USA1,GSK,ResearchTrianglePark,NC,USA2, Wenyuan Qi1, Wei Xue1, Kexin Li1, Soniya Vaidya2, Jian Sun3, GSK, Stockley Park West, Uxbridge, Middlesex, UK3, Johns Yingying Wang3, Hanns-Christian Tillmann4, Chenyu Qian3, Clin- Hopkins Asthma and Allergy Center, Baltimore, MD, USA4, ical Trial Center, Beijing Hospital, National Center of Gerontology; Allergy, Asthma and Immunology Associates, Scottsdale, AZ, Institute of Geriatric Medicine, Chinese Academy of Medical Sci- USA5,GSK,ResearchTrianglePark,NC,USA6, Crisor LLC ences, P.R, China1, Novartis Institutes for BioMedical Research , Research, Clinical Research Institute of Southern Oregon, Cambridge, MA, United States2, Novartis Institutes for BioMedical Medford, OR, USA7 Research, Shanghai, China3, Novartis Institutes for BioMedical Re- 177 Pharmacokinetics Of Indacaterol/Mometasone Furoate In search, Basel, Switzerland4 Healthy Chinese Volunteers: Results From A Randomized, 183 Dupilumab Efficacy in GINA-Defined Difficult-to-Treat Type 2 Open-label, Parallel-group Study Asthma Patients in the LIBERTY ASTHMA QUEST Study Yun Liu1, Weie Cao1, Yijun Wang1, Soniya Vaidya2, Jian Sun3, Klaus Rabe1, J. Mark FitzGerald2, Mario Castro, MD MPH3, Ian Yingying Wang3, Hanns-Christian Tillmann4, Chenyu Qian3, Cen- Pavord, MD4, Jorge Maspero, MD FAAAAI5, William Busse, tral Laboratory, Shanghai Xuhui Central Hospital, Shanghai, China; MD FAAAAI6, Nadia Daizadeh7, Benjamin Ortiz8, Nami Shanghai Engineering Research Center of Phase I Clinical Research Pandit-Abid7, Paul Rowe, MD7, Amin Nikhil8, Yamo Deniz8, & Quality Consistency Evaluation for Drugs, Shanghai, China1, LungenClinic Grosshansdorf and Christian-Albrechts-University Novartis Institutes for BioMedical Research, Cambridge, MA, of Kiel and Christian-Albrechts University of Kiel (member of United States2, China Novartis Institutes for BioMedical Research the German Center for Lung Research [DZL])1, University of Co, Ltd, Shanghai, China3, Novartis Pharma AG, Basel, British Columbia2, University of Kansas School of Medicine3, Switzerland4 NIHR Oxford Biomedical Research Centre, University of Oxford4, 178 Which Severe Asthma Patients Are Switching, Stopping, or Fundacion CIDEA5, University of Wisconsin School of Continuing Biologic Treatments? Medicine and Public Health6, Sanofi7, Regeneron Pharmaceuticals, Weily Soong, MD FAAAAI1, Chris Ambrose, MD MBA2, Donna Inc.8 Carstens2, Frank Trudo, MD2, Wendy Moore, MD3, Reynold Pan- 184 Long-Term Efficacy of Dupilumab in Patients With Asthma ettieri, MD4, Alabama Allergy & Asthma Center1, AstraZeneca2, With an Allergic Phenotype Rolled Over From LIBERTY Wake Forest School of Medicine3, Rutgers University4 ASTHMA QUEST: LIBERTY ASTHMA TRAVERSE Study 179 CAPTAIN: Effects of Cardiovascular Risk on Response to Tri- Lawrence Sher1, Jonathan Corren, MD2, Ian Pavord, MD3, Nadia ple Therapy in Patients With Inadequately Controlled Asthma Daizadeh4, Benjamin Ortiz5, Michel Djandji4, Yamo Deniz5, Paul on Inhaled Corticosteroids/Long-acting b2-agonists (ICS/ Rowe, MD4, Peninsula Research Associates1, David Geffen School LABA) of Medicine at UCLA2, NIHR Oxford Biomedical Research Centre, Nicola Hanania, MD, MS1, Zelie Bailes2, Sarah Chang, PhD3, An- University of Oxford3, Sanofi4, Regeneron Pharmaceuticals, Inc.5 drew Fowler2, Robson Lima3, David Mannino, MD3, Mark Mill- 185 Off-label Prescribing Of Inhaled Corticosteroids In Children ard4, Joseph Spahn, MD3, Steve Weinstein, MD FAAAAI5, With Asthma Robert Nathan, MD FAAAAI6, Baylor College of Medicine, Hous- Stacey Mahady, DO1, David Skoner, MD1, West Virginia Univer- ton, TX, USA1, GSK, Stockley Park West, Uxbridge, Middlesex, sity School of Medicine1 UK2, GSK, Research Triangle Park, NC, USA3, Baylor Scott & 186 Factors Associated With Increased Asthma Exacerbations After White Texas Lung Center, Dallas, TX, USA4, Allergy and Asthma Stopping Biologic Treatment Specialists Medical Group and Research Center, Huntington Beach, Jacob Maddux, Matthew Rank, MD FAAAAI1, Molly Jeffery, CA, USA5, Asthma & Allergy Associates, P.C. and Research Cen- PhD2, Jonathan Inselman3, Ragina Lam4, Nilay Shah5, Mayo Clinic ter, Colorado Springs, CO, USA6 and Foundation1, 3. Division of Health Care Policy and Research, 180 Efficacy of oral Dexamethasone versus oral Prednisone in Department of Health Sciences Research, Mayo Clinic,2, Robert school-aged asthmatics treated in the Emergency Department D. and Patricia E. Kern Center for the Science of Health Care De- at an Academic Medical Center livery, Mayo Clinic3, Mayo Clinic Alix School of Medicine, Scotts- Joseph Howard1, Jay Lieberman, MD FAAAAI2, Daniel Dibaba, dale, AZ4, Division of Health Care Policy and Research, PhD3, Qi Zhao, PhD1, Annette Carlisle, MD4, University of Department of Health Sciences Research, Mayo Clinic,5 J ALLERGY CLIN IMMUNOL Abstracts AB187 VOLUME 147, NUMBER 2

Chronic Cough Fred Hsieh1, Robert Burton1, Cleveland Clinic1, Case Western Re- serve University2 187 Comparing Machine Learning Models for Identifying Chronic 195 Mental Health Concerns among Primary Immunodeficiency Cough Using Diagnosis and Medication in the Electronic Health Patients and their Caregivers Records 1 1 1 1 2 2 Nouf Alsaati , Kathleen Webber , Michael Keller, MD , Linda Vishal Bali, PhD , Xiao Luo, PhD , Priyanka Gandhi, BS , Zuoyi 1 1 3 3 3 Herbert, PhD , Children’s National Hospital Zhang, PhD , Wei Shao, PhD , Zhi Han, PhD , Vasu Chandrase- 196 Assessment of Telomere Length in Patients with Primary Im- karan, PhD1, Vladimir Turzhitsky, PhD1, Anna Roberts, MIS4, 4 4 1 mune Deficiency Megan Metzger, MS , Jarod Baker, MS , Carmen La Rosa, MD , Andrea Sitek1, Avni Joshi, MD FAAAAI1, Mayo Clinic1 Jessica Weaver1, Paul Dexter5, Kun Huang, PhD3, Center for Ob- 1 197 Genetic Panel Testing for Primary Immunodeficiency Diseases servational and Real-World Evidence, Merck & Co., Inc. , Purdue 1 2 2 Kelsey Lecerf, MD , Benjamin Prince, MD MCSI FAAAAI , Re- School of Engineering and Technology , Indiana University School 2 3 4 5 becca Scherzer, MD FAAAAI , The Ohio State University/Nation- of Medicine , Regenstrief Institute, Inc. , Eskenazi Health wide Children’s Hospital1, Nationwide Children’s Hospital2 188 Cough Triggers and Symptoms Among Patients with Refrac- 198 Hospitalizations and Critical Illness in Adult Primary Immuno- tory or Unexplained Chronic Cough in Two Phase 3 Trials of deficiency Patients the P2X3 Receptor Antagonist Gefapixant (COUGH-1 and Arun Dhir1, Persia Pourshahnazari, MD1, Catherine Biggs, MD1, COUGH-2) University of British Columbia1 Alyn Morice, MD1, Surinder Birring, MD2, Peter Dicpinigaitis, MD3, Lorcan McGarvey, MD4, Ian Pavord, MD5, Jaclyn Smith6, Carmen La Rosa, MD7, Qing Li7, Allison Martin Nguyen7, Jona- than Schelfhout7, Anjela Tzontcheva7, David Muccino, MD7, Uni- Cells and Cytokines 1 2 versity of Hull , King’s College, London, UK , Jack D. Weiler 199 Relationship of Blood Eosinophil Counts of Adults with Diabe- 3 4 5 Hospital , Queen , University of Oxford , University of Manches- tes as a Risk Factor for Coronary Artery Disease 6 7 ter , Merck & Co., Inc. Alexander Babazadeh, MD1, Shawn Mathew, MD1, Sairaman Na- 189 Comorbid Conditions and Medical History Among Patients garajan, MD MPH1, Bibi Khartoon, MD1, Rauno Joks, MD with Refractory or Unexplained Chronic Cough in Two Phase FAAAAI1, SUNY Brooklyn Health Sciences University1 3 Clinical Trials (COUGH-1 and COUGH-2) 200 Use of Benralizumab in Refractory Eosinophilic Cystitis Im- 1 2 Peter Dicpinigaitis, MD , Surinder Birring, MD , Lorcan McGar- proves Symptoms and Reduces Bladder Eosinophils 3 4 5 6 vey, MD , Alyn Morice, MD , Ian Pavord, MD , Jaclyn Smith , Cheshil Dixit1, Travis Bullock, MD2, Laura Kahle3, Manoj War- 7 7 7 Carmen La Rosa, MD , Qing Li , Allison Martin Nguyen , Jona- rier, MD FAAAAI3, Saint Louis University1, Urology of St. Louis2, 7 7 7 than Schelfhout , Anjela Tzontcheva , David Muccino, MD , Allergy, Asthma & Food Allergy Centers3 1 2 3 Jack D. Weiler Hospital , King’s College, London, UK , Queen , 201 Overlay Between Th1 and Th2 pathways in Patients with Com- 4 5 University of Hull , University of Oxford , University of Manches- mon Variable Immunodeficiency and Allergic disease 6 7 ter , Merck & Co., Inc. Seemal Awan1, Pavan Nataraj2, Martin Maldonado-Puebla2, Pooja 190 Characterizing Unexplained Chronic Cough In The Primary Dave3, Veronica Mark3, Zachary Falk3, Annette Aldous4, Daniel Care Setting Ein, MD FAAAAI5, National Institutes of Health1, George Wash- Amee Patel, Northwestern Memorial Hospital ington University Hospital2, George Washington University School of Medicine3, Milken Institute School of Public Health4, George Washington University Medical Cen5 202 Transcriptional Features of TH1, TH2, and TH17 priming mi- Primary Immunodeficiency Diagnostics and gratory dendritic cells – a common role for CXCR5 and Chi3l1 Management Miranda Curtiss1, Natalia Ballesteros Benavides1, Beatriz Leon- 1 2 3 4 191 Multidisciplinary Approach to Evaluation and Treatment of In- Ruiz, PhD , Alexander Rosenberg , Chris Scharer , Travis Ptacek , 1 2 2 fantile Onset Inflammatory Bowel Disease Casey Weaver, MD , Troy Randall , Frances Lund, PhD , Univer- 1 Courtney Cotter, DO1, Melissa Keeley, MD2, Ismaeel Hashemi, sity of Alabama at Birmingham , University of Alabama Birming- 2 3 MD2, Nicholas Hartog, MD FAAAAI2, Spectrum Health/ Helen ham , Emory University , University of North Caroline Chapel 4 DeVos Children1, Spectrum Health/ Helen DeVos Children’s Hill Hospital2 203 The Role of Antisense RNA in Gene Expression After Treat- 192 Cancer mortality in a cohort of 202 common variable immuno- ment with Autophagy Modulators deficiency patients from Sao~ Paulo, Brazil, followed for up to Kristina Antuna, MD, Primary Immunodeficiency Diagnostics forty years and COVID-19 Luiz Fonseca, MD, PhD1, Myrthes Barros, MD, PhD2, Cristina Kokron, MD, PhD3, Octavio Grecco, MD, MSc4, Ana Barreto, MD, PhD5, Jorge Kalil, MD, PhD6, Universidade de S~ao Paulo1, Primary Immunodeficiency Diagnostics and Hospital das Clınicas, Faculdade de Medicina da USP, Brazil2, Hos- pital das Clınicas, FMUSP., S~ao Paulo, Brazil3, Hospital das Clıni- COVID-19 cas, Faculdade de Medicina USP4, Hospital das Clinicas, Faculdade 204 COVID-19 and Common Variable Immunodeficiency de Medicina da USP, Brazil5, Faculdade de Medicina da USP, S~ao Marina Kaminski, University graduate1, Gabriela Yoshimoto2, Paulo, Brazil6 Luiza Silva1, Ana Garcia1, Natasha Ferraroni, MD3, UniCEUB1, 193 Microbiota Suppresses Innate Type 2 Immune Responses in the UniCEBu2, Clinica Ferraroni3 lungs in Mice 205 A Case of Mild COVID-19 in a Teenager with Common Varia- Koji Iijima, PhD1, Takao Kobayashi, PhD1, Rinna Tei, MD1, Lisa ble Immunodeficiency and Granulomatous Interstitial Lung Till2, William Moor2, Purna Kashyap2, Hirohito Kita, MD1, Mayo Disease on Replacement Immunoglobulin and Infliximab Clinic Arizona1, Mayo Clinic Rochester2 Yatyng Chang1, Daniel Urschel, MD1, Vivian Hernandez-Trujillo, 194 Undetectable IgE Level Associated with Increased Risk of Ma- MD FAAAAI2, Jose Calderon, MD1, Nicklaus Children’s Hospital, lignancy Division of Allergy and Immunology, Miami, FL1, Allergy and Im- John McDonnell, MD1,KatherineWeller,MD1, Jeff Albert, PhD2, munology Care Center of So2 AB188 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2021

206 DiGeorge Syndrome and COVID-19 in Two Pediatric Patients Latysheva8, Emma Westerman-Clark9, Olajumoke Fadugba, MD10, Eilaf Fallatah1, Yatyng Chang1, Jose Calderon, MD1, Vivian Her- Emma Morris11, Michael Albert12, Dimana Dimitrova13, Despina nandez- Trujillo1, Nicklaus Children’s Hospital1 Moshous14, Jennifer Kanakry15, Steven Holland, MD16, Jean-Pierre 207 Cellular and humoral immunity in patients infected with the de Villartay17, Ravishankar Sargur, MBBS MD FRCPath FRCP18, SARS-CoV-2 virus at general hospital Luigi Notarangelo, MD19, Jolan Walter, MD PhD FAAAAI9,Univer- VAL ERIA BRANDAO~ 1, THAIS TIEMI SAITO, THAIS T sity of South Florida Morsani College of Medicine1, Outpatient Clinic SAITO1,Debora Shibayama Guterres, DEBORA S GUTERRES1, Vienna, Austria2, CHOC Children’s3, Stanford University School of GRASIELE DE OLIVEIRA DE LIMA, GRASIELE LIMA1, Medicine4, Belarusian Research Center for Pediatric Oncology and SARA RAMILO TENCARTE, SARA TENCARTE1, ANA CARO- Hematology5, Alfred Rusescu Institute for Mother and Child6,Charles LINA MONTEIRO BRUNETTI DOS SANTOS, ANA CAROLINA University in Prague7, NRC Institute of Immunology FMBA Russia, DOS SANTOS2, MARINA ALMEIDA PRADO MEIRELES Russian Federation8, University of South Florida9, University of Penn- LAUBI, MARINA LAUBI3, Roselene Lourenc¸o, ROSELENE sylvania10, UCL Institute of Immunity and Transplantation11,Drvon LOURENC¸ O4, Octavio Grecco, MD, MSc5, Myrthes Toledo Bar- Haunersches Kinderspital, Lidwig-Maximilians-Universitat12,Na- ros8, Myrthes T Barros6, Cristina Maria Kokron, Cristina Kokron6, tional Institute of Allergy and Infect13, Necker-Enfants Malades Uni- Ana Karolina Marinho, DO7, Conjunto Hospitalar do Mandaqui, versity Hospital Paris14, National Institute of Allergy and Infectious S~ao Paulo, Brazil1, Universidade Nove de Julho, S~ao Paulo, Brazil2, Diseases15,NIH16, Institut Imagine Hopital Necker Enfants Malades17, Universidade Nove de Julho, S~ao Paulo, Brazil,3, Conjunto Hospi- Northern General Hospital18, NIAID/NIH19 talar do Mandaqui and Universidade Nove de Julho, S~ao Paulo, 216 Clinical and Treatment History of Patients with Partial Di- Brazil4, Hospital das Clınicas Universidade de S~ao Paulo5, Hospital George Syndrome and Autoimmune Cytopenia das Clınicas University of S~ao Paulo6, Hospital das Clınicas Uni- Priya Patel1, Emma Westermann-Clark, MD2, Sonia Joychan3, Ah- versity of Sao Paulo Medical School7, Hospital das Clı´nicas, mad Shaker, MD4, Boglarka Ujhazi, BS5, Cristina Meehan, BS5, FMUSP, Sa˜o Paulo, Brazil8 Maryssa Ellison, BS5, Krisztian Csomos6, Sumai Gordon, BS5, 208 Intravenous Immunoglobulin for Treatment of Severe Corona- Daime Nieves, APRN5, Jaz Mateus, MPH1, Irmel Ayala, MD1, Jo- virus Disease 19 (COVID-19) – A Literature Overview lan Walter, MD PhD FAAAAI5, Panida Sriaroon, MD FAAAAI5, Syed Rizvi1, Huub Kreuwel2, Octapharm1, Octapharma2 Johns Hopkins All Children’s Hospital1, James A. Haley Veterans 209 An effective approach for recombinant production of select Hospital2, Dearborn Allergy & Asthma Clinic, P.C.3, Baycare Med- SARS-CoV-2 proteins in Escherichia coli ical Group4, University of South Florida5, Massachusetts General Sayeh Agah1, Catherine Thorpe2, Martin Chapman, PhD Hospital6 FAAAAI2, Sabina Wuenschmann, PhD2, Indoor Biotechnologies1, 217 Systemic inflammatory syndromes with immunodysregulatory INDOOR Biotechnologies, Inc.2 phenotype: clinical characteristics, genetic findings and thera- peutic response. Grazielly Pereira, Pereira GF1, Alex Prado, MD2, Jaqueline 2 2 Immunodysregulation Brand~ao, Brand~ao,JC , Francine Zanetti, Zanetti, FA , Nazoneth Alberto, Samucanda alberto, NE2, Jorge Kalil, MD, PhD2, Luiz 210 Two novel variants in signal transduction and activator of tran- Fonseca, MD, PhD3, Fabio Castro, Castro, FF4, Myrthes Toledo- scription 1 (STAT1) coiled-coil region cause STAT1 gain of func- Barros, Barros, MAM1, Leonardo Mendonc¸a, Mendonc¸a, LO1, tion in an infant presenting with Pneumocystis jiroveci Hospital das Clınicas, FMUSP, S~ao Paulo, Brazil1, USP2, Universi- pneumonia (PJP) and CMV viremia ~£ 3 ~£ 4 1 1 dade de SA o Paulo ,SA o Paulo University Tina Banzon, MD , Sandra Burchett, MD , Andrew Wehrman, 218 Diagnostic Dilemma on Novel Pathogenic Variant of Cytotoxic 1 1 1 MD , Pui Lee, MD, PhD , Craig Platt, MD PhD , Boston Chil- T-Lymphocyte Associated Protein 4 (CTLA-4) in a Family 1 dren’s Hospital with Chronic ITP and Immune Dysregulation 211 Germline RUNX1 Deficiency Predisposes to Allergy and Auto- Priyanka Timothy, MD1, Mary Ann Miranda, MD1, Jocelyn immunity 2 1 1 1 1 Farmer, MD PhD , Jolan Walter, MD PhD FAAAAI , Emma West- Keith Sacco , Karen Laky, PhD , Min (Jenny) Li, PhD , Matt Mer- 1 1 2 2 3 ermann-Clark, MD , University of South Florida , Massachusetts guerian, MD PhD , Kathleen Craft , Lea Cunningham, MD , Paul 2 2 1 General Hospital Liu, MD PhD , Pamela Guerrerio, MD PhD , National Institute 219 Chronic Granulomatous Disease (CGD): Presentation at Diag- 1 of Allergy and Infectious Diseases, NIH, Bethesda, MD , National nosis and Burkholderia Colonization 2 Human Genome Research Institute, NIH, Bethesda, MD , National Amrita Dosanjh, MD1, RCHSD1 Cancer Institute, NIH, Bethesda, MD3 212 Successful treatment of severe autoimmune enteropathy in a pe- diatric heart transplant recipient with abatacept and alemtuzu- mab Elizaveta Kalaidina1, Elisabeth Utterson, MD1, Mai He, MD Severe Combined Immunodeficiency (SCID) and PhD1, Megan Cooper, MD PhD1, Washington University School of Medicine1 on the Lymphopenic Disorders 213 Undiagnosed, familial cold auto-inflammatory syndrome 220 Hereditary heterozygous FoxN1 variant with associated T cell (FCAS) masquerading as COVID-19 cytokine storm. lymphopenia in a family Dilawar Khokhar, MD1, James Baker, MD FAAAAI1, University Andrea D’Mello, MD1, Amara Seng1, Marissa Love, MD1, Uni- of Michigan1 versity of Kansas Medical Center1 214 Schnitzler Syndrome With Extremely Elevated IL-6 Responds 221 A Novel De Novo PGM3 Pathogenic Mutation Identified in an To Anti IL-1 Receptor Antagonist Infant Presenting with Abnormal TREC Assay and Severe Neu- Kevin Diehl, Zaynab Ashoor1, Timothy Craig, DO FAAAAI2, tropenia Cairo University1, Penn State University2 Andrew Winslow1, Elizabeth Jalazo, MD1, Thomas Felton, MS 215 Are we diagnosing too late? RAG deficiency in young adults CGC2, Eric Weimer, PhD2, Nathan Montgomery, MD PhD1, Mi- with end organ damage chael Winstead, MD1, Timothy Moran, MD PhD1, University of Tara Saco1, Christoph Geier2, David Buchbinder3, Joseph Hernan- North Carolina School of Medicine1, University of North dez4, Svetlana Sharapova5, Alexis Cochino6, Tomas Milota7,Elema Carolina2 J ALLERGY CLIN IMMUNOL Abstracts AB189 VOLUME 147, NUMBER 2

222 In-Utero Exposure to Immunosuppressive Medications Result- Yvelise Barrios del Pino1, Elena Mederos Luis1,CristinaAlava1, ing in Abnormal Newborn Screening for Severe Combined Im- Paloma Poza Guedes, MD PhD2, Andres Franco1, Teresa Delgado1, munodeficiency (SCID) Taida Martın1,IsabelSuarez1, Victor Matheu, MD, PhD1,Hospital Elisa Ochfeld1, Aisha Ahmed1, Northwestern University Feinberg Universitario de Canarias1, Hospital Universitario de Canarias, School of Medicine, Ann & Robert H. Lurie Children’s Hospital of Tene2 Chicago1 233 The Impact of Immunodeficiency on Patients Receiving Immu- 223 Characterizing Neutropenia in Severe Combined Immunodefi- nologic-Based Multiple Sclerosis Therapies ciency Michael Runken, PharmD1, Terry Harville, MD PhD2, Joshua No- Abeer Siddiqi1, Angela Chan, MD1, Elizabeth Garabedian, RN, one, PhD3, Grifols SSNA1, University of Arkansas Medical Sci- MSLS2, Ramsay Fuleihan, MD FAAAAI1, Joyce Yu, MD ences2, University of North Carolina at Charlotte3 FAAAAI1, Deepti Deshpande, MD1, Columbia University Irving 234 Infections and associated diseases in patients with mannose-binding Medical Center1, NIH2 lectin deficiency, presenting to a tertiary care immunology clinic 224 Omenn Syndrome with Autoreactive T-cell development after Blanka Kaplan, MD FAAAAI1, Alissa McInerney, MD1,Northwell viral infections in two patients with Leaky Severe Combined Health1 Immunodeficiency (SCID) 235 Assessing Severity in Common variable immune deficiency Maria Chitty-Lopez, MD1, Jessica Trotter, MA BS1,CarlaDuff, (CVID) using the ‘‘Ameratunga Score- AS’’ CPNP-PC APRN MSN CCR1, Gretchen Vaughn, APRN MSN2, Rafaela Guimaraes1, Luiza Schmid2,Lıgia Machado2, Mariana Pi- Benjamin Oshrine, MD2,GauriSunkersett,DO2, Jennifer Leiding, mentel3,MariaC^andida Rizzo4, Carolina Aranda1, Dirceu Sole, MD MD FAAAAI1, University of South Florida, St. Petersburg, FL, USA1, PhD FAAAAI5, Federal University of Sao Paulo1,UNIVERSIDADE Johns Hopkins All Children’s Hospital, St. Petersburg, FL, USA2 FEDERAL DE SAO~ PAULO - UNIFESP2, Federal University of 225 Maternal Immunosuppression for Myasthenia Gravis Mimick- SA~£o Paulo3, UNIVERSIDADE FEDERAL DE SAO~ PAULO -UNI- ing SCID on Newborn Screening FESP4, Universidade Federal de Sao Paulo5 Jenyfeer Blanco1, Anne Yates, MD FAAAAI2, University of Mis- 236 Frequency of Follicular T cells in a cohort of Brazilian Common sissippi Medical Center1, University MS Medical Center2 Variable Immunodeficiency (CVID) patients Cristina Kokron, MD, PhD1, Fernando Zilinski, biomedicine, MSc student2, Bianca Santos, MSc, PhD student2, Erica Coutinho, MSc2, Juliana Apostolico, PhD3, Milena Andrade, MSc student2, Humoral Immunodeficiency Ana Karolina Marinho, DO4, Myrthes Barros, MD, PhD2, Octavio 226 Difference in clinical characteristics of patients with common var- Grecco, MD, MSc2, Jorge Kalil, MD, PhD2, Hospital das Clınicas, iable immunodeficiency (CVID) according to pulmonary altera- Faculdade de Medicina, USP1, Faculdade de Medicina, Universi- tions - A cohort of 182 patients from a Brazilian tertiary hospital dade de S~ao Paulo2, Universidade Federal de S~ao Paulo3, University Priscila Franco, MD1, Rosana Agondi, MD PhD1, Grazielly Pereira3, of Sao Paulo Medical School4 Pereira GF1, Octavio Grecco, MD, MSc2, Ana Karolina Marinho, 237 Evaluating Safety, Tolerability, and Efficacy of Subcutaneous DO2, Myrthes Toledo Barros3, Myrthes T Barros2, Jorge Kalil, MD, Human Immunoglobulin 16.5% Administered at Modified Dos- PhD2, Cristina Kokron, MD, PhD2, University of S~ao Paulo1,Univer- ing Regimens in Patients with Primary Immunodeficiency Dis- sity of Sao Paulo2,HospitaldasClı´nicas,FMUSP,Sa˜oPaulo, eases – Study Design Brazil3 Isaac Melamed, MD1, Sudhir Gupta, MD PhD FAAAAI2, Roger 227 Detection and Characterization of Specific Anti-Apolipoprotein Kobayashi, MD FAAAAI3, Michael Eppolito, MBA4, Joanna Mal- E4 IgG Antibodies in Human Plasma and an Intravenous Im- tese, BSN4, Syed Rizvi4, Ai Kobayashi5, IMMUNOe Health Cen- munoglobulin Preparation (Gammagard Liquid) ters1, University of California at Irvine2, Allergy Asthma & Alfred Weber1, Andrea Engelmaier1, Eva Minibeck1, Baxalta In- Immunology Assoc3, Octapharma4, Midlands Pediatric5 novations GmbH, now part of Takeda1 238 Long-Term Safety, Efficacy, and Tolerability of Subcutaneous 228 Real-World Evaluation of Immune Globulin Subcutaneous Human Immunoglobulin 16.5% in Patients with Primary Im- 16.5% in the Treatment of Primary Immunodeficiency munodeficiencies Jeffrey Langford, MD1, Richard Herrscher, MD2, Samantha Sudhir Gupta, MD PhD FAAAAI1, Roger Kobayashi, MD Mehta, PharmD3, Lucinda Van Anglen, PharmD3, Langford Al- FAAAAI2, Isaac Melamed, MD3, Syed Rehman4, Ai Kobayashi5, lergy, LLC1, AIRCare P.A.2, Healix Infusion Therapy, LLC3 jose-fernando Mandujano, MD6, Bob Geng, MD7, Bruce Ritchie, 229 Impact of immunization with pneumococcal conjugated vac- MD8, University of California at Irvine1, Allergy Asthma & Immu- cines on the aplicability of the diagnostic criteria for specific nology Assoc2, IMMUNOe Health Centers3, Asthma & Allergy pneumococcal antibody deficiency Center4, Midlands Pediatrics, P.C5, Children’s Health6, Rady’s Daniela Navarrete-Cortes1, David Rodriguez-Cabezas, MD1, Children hospital San Diego7, University of Alberta, Canada8 Marıa Cristina Mayol1, Antonia Sanchez1, Aileen Ferran1, Nicole 239 Impact of Immunodeficiency on Multiple Sclerosis Patients Re- Silva1, Constanza Silva1, Teresa Quiroga, MD1, Katia Abarca, ceiving Rituximab MD1, Rodrigo Hoyos1, Pontificia Universidad Catolica de Chile Terry Harville, MD PhD1, Michael Runken, PharmD2, Joshua No- School of Medicine1 one, PhD3, University of Arkansas Medical Sciences1, Grifols 230 Long-term Safety of Facilitated Subcutaneous Immunoglobulin SSNA2, University of North Carolina at Charlotte3 Treatment in Patients With Primary Immunodeficiency Dis- eases: Interim Analysis from a Post-authorization Safety Study Arye Rubinstein1, Albert Einstein College of Medicine1 COVID-19 and Viral Infections in Allergy and 231 Lower IgM levels after rituximab use is associated with sepsis Idil Ezhuthachan1, Mara Shapero2, Joanna Fishbein3, Blanka Ka- Asthma plan, MD FAAAAI3, Steven & Alexandra Cohen Children’s Medi- 240 Risk Factors for Mortality from COVID-19 in a New York In- cal Center of NY1, Steven & Alexandra Cohen Children’s Medical ner city Epicenter Center of NY2, Northwell Health3 Mariam Majzoub1, Rauno Joks, MD FAAAAI2, Center of Allergy 232 Assessment of Immune Function Status using Polysaccharide and Asthma Research, SUNY Brooklyn Health Science Univer- Vaccination in Secondary Immunodeficiencies sity1, SUNY-HSC2 AB190 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2021

241 Point-of-care assays can detect COVID-19 antibodies via serum University School of Medicine, Washington, DC, USA; Immunol- or whole blood ogy Research Institute of New England, Gardner, MA, USA3 Charles Schuler, MD1, James Baldwin, MD FAAAAI2, James 250 Effects of Virus Specific Short-Interfering RNAs on Enterovirus Baker, MD FAAAAI1, University of Michigan1, University of D68 Induced Lung Injury Michigan Allergy Immunolog2 Nicholas Klaiber1, Michael McVoy1, Wei Zhao, MD PhD 242 Does Point-Of-Care SARS-CoV-2 Antibody Testing Have Simi- FAAAAI1, Department of Pediatrics, Virginia Commonwealth Uni- lar Sensitivity and Specificity To High Complexity Serology? versity, Richmond, VA, USA1 Kelly O’Shea, MD1, Charles Schuler, MD1, Jesse Chen1, Carmen Gherasim, PhD1, Donald Giacherio, PhD1, James Baldwin, MD FAAAAI2, James Baker, MD FAAAAI1, University of Michigan1, University of Michigan Allergy Immunolog2 Pollen and Environmental Factors 243 Multi-system Inflammatory syndrome in Children (MIS-C): an 251 Effect of cigarette smoking on M1/M2 type Alveolar Macro- evolving presentation of COVID-19 in the pediatric population: phage (AM) and the restoration of AM by smoking cessation A Florida State experience and our management approach Minoru Takeuchi1, Honami Nakata1, Kent Pinkerton2, Kyoto San- 1 1 1 Farida Karim, MD , Miry Makebish , Pallavi Agarwal , Callah gyo University1, University of California - Davis2 1 1 Antonetti, MD , University of Florida Pensacola 252 Ultrasonic ‘‘Mite Killers’’ Fail to Decrease Mites in Carpeting 244 Prenatal and Perinatal Risk Factors for Lower Respiratory Jeffrey Miller1, New York Medical College and Mission: Allergy, Tract Infections in Inner-city Minority Infants Inc.1 1 Maria Gutierrez , Johns Hopkins University1 253 Visual Machine Learning and Artificial Intelligence Application 245 Implications of the COVID-19 Pandemic on Asthma Control in Aeroallergen Identification During Spring, Summer, and Fall and Socioeconomic Factors in Inner-City Cohort: A Rapid On- Pollen Season line Cross-Sectional Survey Richard Lucas, PhD1,LandonBunderson2,JamesAnderson,MLT3, 1 1 Thanaporn Ratchataswan , Christina Yee, MD PhD , Caroline Dan Dalan, MD4, Southwest Environmental Institute1,PollenSense2, 1 2 Mortelliti , Amparito Cunningham, MD MPH , Lisa Bartnikas, Environmental Allergy Assays3, MercyOne Medical Center4 1 1 MD , Wanda Phipatanakul, MD MS FAAAAI , Boston Children’s 254 Assessment of reduction of the PM 2.5 and fungal spores using 1 2 Hospital , Harvard University AFL Facemask 246 Clinical Characteristics of SARS-CoV2 Infected and Exposed Pa- Nabarun Ghosh1, Constantine Saadeh2, Aubrey Howard, BS1, Jay tients at a Tertiary Care Allergy/Immunology Program in Florida Vitale, BS3, Prabir Banerjee, MD MS4, West Texas A&M Univer- 1 2 2 Mary Ann Miranda, MD , Joseph Dasso , Maryssa Ellison, BS ,Jes- sity1, Allergy ARTS, Amarillo2, Air for Life UK3, R N Tagore Hos- 3 4 sica Trotter, MA BS ,PriyankaTimothy,MD, Maria Chitty-Lopez, pital, Calcutta, India4 MD5, Carla Duff, CPNP-PC APRN MSN CCR2, Daime Nieves, 255 Use of a HEPA filter associated with a decrease in urgent med- APRN2, Emma Westermann-Clark, MD2, Nathan Tang2,Mandel ical visits and hospitalizations for asthma among children living Sher, MD FAAAAI2, Mark Ballow, MD FAAAAI2,JenniferLeiding, in lower-income New York City apartments. 2 2 MD FAAAAI , Panida Sriaroon, MD FAAAAI , Jolan Walter, MD Luis Acosta, MD1, Ray Lopez2, Sergio Galvez2, Regina Dominguez1, 2 1 PhD FAAAAI , Children’s Research Institute ,UniversityofSouth Linda Weiss3, Matthew Perzanowski, PhD1, Columbia University, 2 3 Florida , University of South Florida - CRI , University of South Flor- Mailman School of Public Health1, Little Sisters of the Assumption 4 5 ida/Johns Hopkin , Johns Hopkins All Children Family Health Service2, The New York Academy of Medicine3 247 COVID-19 Severity in Hospitalized Pediatric Patients with 256 Annual Comparison of Weed Pollen in Las Vegas and the Mo- Atopic Disease jave Desert 2017-2019 1 2 Dylan Timberlake , Rebecca Scherzer, MD FAAAAI , Benjamin Joseph Jean1, Asma Tahir, MPH1, Samin Kamal1, Mark Buttner1, 3 2 Prince, MD MCSI FAAAAI , Mitchell Grayson, MD , The Ohio Dennis Bazylinski1, Joram Seggev, MD FAAAAI1, University of 1 State University/Nationwide Children’s Hospital , Nationwide Nevada Las Vegas1 Children2, Nationwide Children’s Hospital3 257 Effects of 20,000 EU of Clinical Center Reference Endotoxin 248 ‘‘COVID-19 pandemia: Atopy and prospective analysis of the (CCRE) versus placebo on systemic and cardiovascular inflam- clinical evolution of patients infected with the SARS-CoV-2 vi- matory responses in mild asthmatics and healthy volunteers rus’’ Stephen Schworer, MD PhD1, Alan Hinderliter, MD1, Melissa 1 Debora Shibayama Guterres, DEBORA S GUTERRES ,ANA Caughey, PhD2, Carole Robinette1, Kelly Chason, BS3, Allison CAROLINA MONTEIRO BRUNETTI DOS SANTOS, ANA Burbank, MD4, Michelle Hernandez, MD FAAAAI1, UNC School 2 CAROLINA DOS SANTOS , Marina de Almeida Prado Meireles of Medicine1, University of North Carolina and North Carolina 2 2 Laubi , Marina Laubi , Roselene Lourenc¸o, ROSELENE State University2, UNC-Chapel Hil3, University of North Carolina, 1 1 LOURENC¸ O , Marcus Vinıcius Vaz Cavalcanti, Marcus Vinıcius , Chapel Hill4 3 4 Rosana Agondi, MD PhD , Ana Karolina Marinho, DO ,VALE- 258 Profile of Airborne Pollen in a Recently Placed Station In Ma- ~ 5 5 RIA BRANDAO , Thais Tiemi Saito, Thais Saito , Grasiela Oli- drid: Description Of Levels Of Pollen In the Last Three Years. 5 veira de Lima, Grasiela Lima , Conjunto Hospitalar do Marıa Cervera Garcıa1, Maria Somoza Alvarez, MD2,AnaMarAa~ 1 Mandaqui, S~ao Paulo, Brazil , Universidade Nove de Julho, S~ao Prieto-Moreno Pfeifer, CME1,IsabelTorresRojas,CME1, Teresa Alfaya Paulo, Brazil2, Hospital das Clınicas Universidade de S~ao Paulo, Arias3, Diana Perez Alzate, MD4, Elisa Haroun-Diaz1, Maria Vazquez S~ao Paulo, Brazil3, University of Sao Paulo Medical School4, Con- de La Torre5, Francisco Ruano, Allergist4, Paula Lopez, MD1, Natalia 5 junto Hospitalar do Mandaqui Blanca Lopez 1, Francisco Feo Brito3, Gabriela Canto, MD, PhD1,In- 249 Characterization of T cell, B cell and Natural Killer Cell Sub- fanta Leonor University Hospital1, Allergy Therapeutics Iberica sets in COVID-19 Patients S.L.U.2, General University Hospital of Ciudad Real3, Hospital Univer- 1 1 1 Alena Rynda , Andrei Hancharou , Natalia Antonevich , Oxana sitario Infanta Leonor4, Hospital Infanta Leonor5 Timohina1, Yana Minich1, Alena Halavach1, Darya Babrukevich1, 259 Depression Scores and TNF-a in Participants of a Smoking Ces- Marina Dotsenko2, Eduard Dotsenko2, Lawrence Dubuske, MD sation Program 3 FAAAAI , The Institute of Biophysics and Cell Engineering of Na- Kelsey Field, MD1, Cassandra Derella, BS1, Ryan Harris, PhD1, tional Academy of Sciences of Belarus, Minsk1, Belarusian State Kathleen May, MD FAAAAI1, Martha Tingen, PhD, RN1, Medical 2 Medical University, Minsk, Belarus , George Washington College of Georgia at Augusta University1 J ALLERGY CLIN IMMUNOL Abstracts AB191 VOLUME 147, NUMBER 2

260 Stability of Cockroach Allergens Versus Non-allergens de Alergia e Inmunologia del Sur2, Instituto de Alergia E Aurora Cabrera1, Alexander Foo2, Jill Glesner3, Sayeh Agah4, Imm. Del Sur3 Lisa Vailes3, Sabina Wuenschmann, PhD3, Thomas Randall2, 271 The advance in Poaceae pollen seasonality pattern may impact Anna Pomes, PhD FAAAAI3, Michael Fitzgerald5, Geoffrey Muel- allergy treatment practice ler, PhD2, Duke University1, NIEHS2, Indoor Biotechnologies, Juliana Camargo1, Sebastian Brill2, Cinthya Souza3, Bruna Seb- Inc.3, Indoor Biotechnologies4, Professor of Chemistry5 ben3, Theotonio Pauliquevis4, Philip Taylor5, Ricardo Godoi6, Fed- 261 Applying deep learning to pollen identification using metabolic eral University of Parana1, Multiphase Chemistry Department, Max fingerprints Planck Institute for Chemistry, 55128 Mainz, Germany2, Depart- Les Klimczak1, Cordula Ebner von Eschenbach2, Peter Thompson, ment of Pediatrics, Federal University of Parana, Curitiba 80060- PhD3, Jeeroen Buters, PhD4, Geoffrey Mueller, PhD1, NIEHS1, 240, Brazil3, Department of Environmental Sciences, Federal Uni- Technical University of Munich2, North Carolina State University3, versity of S~ao Paulo, Diadema, Brazil4, Department of Pharmacy ZAUM- Center of Allergy & Environment4 and Biomedical Sciences, La Trobe University, Bundoora, Aus- 262 Comparative Incidence of Sensitivity to Oak and Alder in San tralia5, Environmental Engineering Department, Federal University Francisco of Parana, Parana, Brazil6 Bryce Hoffman, MD1, Christina B. Phan, MD1, Julia Wei2,Peg 272 Impact of Climate Change on Tree Pollen Levels in Southern Strub, MD FAAAAI1, Kaiser Permanente, San Francisco, CA1, Ontario Kaiser Permanente, Oakland, CA2 James Anderson, MLT1, Peter Pityn, PhD2, Environmental Al- 263 Comparative Incidence of Skin Test Reactivity to Johnson, Tim- lergy Assays1, Oshtech Incorporated2 othy, and Bermuda Grasses in San Francisco Christina B. Phan, MD1, Bryce Hoffman, MD1, Andrew Louie1, Julia Wei2, Peg Strub, MD FAAAAI1, Kaiser Permanente, San Francisco, CA1, Kaiser Permanente, Oakland, CA2 264 Comparative Incidence of Skin Test Reactivity to Russian This- Diagnosis of Food Allergy tle, Lambs Quarter and Pigweed in San Francisco 273 Diagnostic accuracy of different commercial walnut extracts in 1 2 2 Julia Wei , Bryce Hoffman, MD , Christina B. Phan, MD , Peg a paediatric atopic population 2 1 Strub, MD FAAAAI , Kaiser Permanente, Oakland, CA Kaiser Maria Abreu-Ramırez1, Victoria Fuentes-Aparicio1, Cristina Mo- 2 Permanente, San Francisco, CA rales-Cabeza2, Alberto Alvarez-Perea 1, Sonsoles Infante, MD2, 265 Nasal Allergic Symptoms are Highly Reproducible in Cat-Aller- Carmen Beorlegui3, Paloma Jaqueti Moreno4, Paula Cabrera-Frei- gic Mild Asthmatics in a Naturalistic Exposure Chamber tag4, Hospital General Universitario Gregorio Maran~on, Madrid, 1 1 William Yang, MD FAAAAI , Suzanne Kelly, PhD , Laura Haya, Spain1, Hospital General Universitario Gregorio Maran~on, Madrid, 1 1 2 2 PhD , Rym Mehri , Divya Ramesh , Michelle DeVeaux , Pretty Spain2, Navarre Government3, Pediatric Allergy Unit, Hospital 2 2 2 3 Meier , Sumit Narula , Furat Shawki , Lorah Perlee, PhD , Gary General Universitario Gregorio Maran~on, Madrid, Spain4 2 2 1 Herman, MD , Meagan OBrien , Red Maple Trials Inc. , Regen- 274 Clinical predictors and outcomes of oral food challenges illus- 2 3 eron Pharmaceuticals, Inc. , Regeneron Pharmaceuticals Inc. trate differences among individual tree nuts 266 Wind Influence on the Grass Airborne Pollen in Bahıa Blanca, Cynhia Hsu1, Meagan Yong1, Jacob Pozin1, Melanie Makhija, Argentina. MD1, Anne Marie Singh, MD2, Northwestern Feinberg School of 1 1 German Ramon, MD FAAAAI , Laura Barrionuevo, biologist , Medicine1, University of Wisconsin2 2 2 Graciela Benedetti , Valeria Duval, Geography PhD , Instituto de 275 Proteomic profiling of the inflammatory response during oral 1 2 Alergia e Inmunologia del Sur , Universidad Nacional del Sur challenge to peanut 267 Asthma Prevalence and Mold Levels in US Northeastern Nicole Ramsey, MD PhD1, Charuta Agashe2, Anna Nowak-Wegr- Schools zyn, MD, PhD3, Julie Wang, MD FAAAAI4, Scott Sicherer, MD 1 2 3 4 Evin Howard , Stephen Vesper , Barbara Gunthrie , Carter Petty , FAAAAI5, Cecilia Berin, PhD6, Mount Sinai Hospital1, Icahn 5 6 Valeria Ramden , Will Sheehan, MD FAAAAI , Jonathan Gaffin, School of Medicine at Mt Sinai2, NYU Langone Health3, Icahn 7 8 9 MD , Perdita Permaul, MD FAAAAI , Peggy Lai, MD , Lisa Bart- School of Medicine at Mount Sinai4, Mt. Sinai School of Medi- 4 10 nikas, MD , Amparito Cunningham, MD MPH , Marissa Haupt- cine5, Mount Sinai School of Medicine6 7 11 12 man, MD , Diane Gold, MD , Sachin Baxi , Wanda 276 Factors associated with tolerating double-blind placebo-con- 4 Phipatanakul, MD MS FAAAAI , Boston Children’s Hospital and trolled food challenge in school-aged children 1 2 Northeastern University , Environmental Protection Agency , Sofianne Gabrielli, MSc1, Bruce Mazer, MD FAAAAI2, Danbing 3 4 Northeastern U , Boston Children’s Hospital , Northeastern Univer- Ke, PhD3, Christine McCusker, MD MSc4, Michelle Le, MD1, 5 6 7 sity , Children’s National Medical Center , Boston Children ,NY Lydia Zhang, MD1, Liane Beaudette, RN1, Duncan Lejtenyi, 8 Presbyterian Hospital/Weill Cornell Medicine , Massachusetts MSc1, Edmond Chan, MD FAAAAI5, Ingrid Baerg6, Julia Upton, 9 10 General Hospital , Harvard University , Channing Division of MD7, Eyal Grunebaum, MD8, Ann Clarke9, Moshe Ben-Shoshan, 11 12 Network Medicine , Children MD FAAAAI1, McGill University Health Centre1, The McGill 268 Forecasting Airborne Pollen for Allergy Management for Con- University Health Centre2, McGill University Health Center tiguous United States Research3, Montreal Children’s Hospital, McGill University 1 1 Jeremy Hess, MD MPH ,FionaLo,PhD, University of Health Centre4, BC Children5, BC Children’s Hospital6, The Hospi- 1 Washington tal for Sick Children7, Hospital for Sick Children8, University of 269 Using Hourly Pollen Data to Quantify Relevant Distance and Calgary9 Response Times of Hay Fever Symptoms Following Exposure 277 Separation from major allergens and co-purification of two mi- to Local Pollen Peaks nor allergens in peanut extract 1 2 3 Richard Lucas, PhD , Landon Bunderson , Dan Dalan, MD , Jane McBride, MS1, Soheila Maleki, PhD FAAAAI2, Barry Hurl- 1 2 Southwest Environmental Institute , Pollen Sense , Self burt, PhD3, USDA Agricultural Research Service1, USDA-Agricul- 3 employed tural Research Service2, USDA3 270 Airborne pollen analysis during one year in the city of Trelew, 278 Panel of Unintended Consequences Argentina. Daniel Urschel, MD1, Jose Calderon, MD1, Vivian Hernandez-Tru- 1 2 Gabriel Fueyo , Laura Barrionuevo, biologist ,GermanRa- jillo, MD FAAAAI2, Nicklaus Children1, Allergy and Immunology 3 1 mon, MD FAAAAI , Centro Cardiologico Trelew , Instituto Care Center of So2 AB192 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2021

279 Characteristics of Reactions that Pass During Oral Food Chal- Sheyman, MD2, Hector Alcala, PhD, MPH, CPH3, Michelle Tobin, lenges MD1, Alexandra Guillaume, MD2, Stony Brook Children’s Hospi- Katherine Weller, MD1, Jaclyn Bjelac, MD1, Samantha Knox1, tal1, Stony Brook University Hospital2, Stony Brook University3 Wei Liu1, Cleveland Clinic1 289 Increased Prevalence of Eosinophilic Esophagitis (EoE) in Chil- 280 The use of LAD2 cells in the mast cell activation test (MAT): a dren with Inflammatory Bowel Disease (IBD) potential tool for food allergy diagnosis. Ryan Eid1, Christina Mounzer2, Michael Mendoza, MD2, Jeremy Mohammad Farazuddin1, Nicholas Ludka, BS1, James Baker, Middleton, MD1, Barrett Barnes, MD2, Emily McGowan, MD MD FAAAAI1, University of Michigan1 PhD FAAAAI3, University of Virginia1, The University of Vir- 281 Applicability of US-based risk stratification for oral food chal- ginia2, University of Virginia School of Medicin3 lenges in Chilean pediatric population 290 Dupilumab Improves Health-Related Quality of Life (HRQoL) Florencia Neumann1, Sara Concha1, Josefina Castagnoli1, Arturo and Reduces Symptom Burden in Patients with Eosinophilic Borzutzky, MD FAAAAI1, Rodrigo Hoyos2, Pontificia Universidad Esophagitis (EoE): Results From Part A of a Randomized, Pla- Catolica de Chile1, Pontificia Universidad Catolica de Chile2 cebo-Controlled Three-Part Phase 3 Study 282 Outcome of Double-Blind Placebo-Controlled Food Challenges Evan Dellon, MD1, Marc Rothenberg, MD PhD FAAAAI2, Ikuo in Shrimp-Sensitized Participants Hirano, MD3, Mirna Chehade, MD MPH4, Albert J Bredenoord5, Shirly Jiang, MD1, Divya Kumar, PhD2, Shu Cao2, Jessica Fitzpa- Jonathan Spergel, MD, PhD6, Qiong Zhao7, Bethany Beazley7, Isa- trick2, Andrew Long, PharmD3, Margaret Woch2, Jenny Johans- belle Guillemin8, Leda Mannent, MD8, Elizabeth Laws8, Nikhil son2, Kari Nadeau, MD PhD FAAAAI4, Sharon Chinthrajah, Amin, MD7, Brad Shumel, MD7, Jennifer Maloney7, Siddhesh Ka- MD2, Sayantani Sindher, MD2, Santa Clara Valley Medical Center1, mat7, University of North Carolina School of Medicine1, Cincinnati Stanford University - Sean N. Parker Center for Allergy and Children’s Hospital Medical Center and University of Cincinnati Asthma Research2, Stanford University3, Stanford Univ School College of Medicine2, Northwestern University Feinberg School Medicine4 of Medicine3, Mount Sinai Center for Eosinophilic Disorders, Icahn 283 Skin Test Reactivity After Food-Induced Anaphylaxis: A 5 Year School of Medicine at Mount Sinai4, Amsterdam University Med- Retrospective Review ical Center5, Children’s Hospital of Philadelphia6, Regeneron Phar- Monica Kraft, MD1, Benjamin Prince, MD MCSI FAAAAI2, Re- maceuticals, Inc.7, Sanofi8 becca Scherzer, MD FAAAAI3, Irene Mikhail, MD3, Peter Mus- 291 Efficacy And Safety Of Budesonide Oral Suspension In A Pedi- tillo, MD FAAAAI2, Nationwide Children’s Hospital/ The Ohio atric Population: Pooled Data From A Phase 2 And Phase 3 State University1, Nationwide Children’s Hospital2, Nationwide Trial In Patients With Eosinophilic Esophagitis Children3 Sandeep Gupta1, Vincent Mukkada2, Evan Dellon, MD3, Benja- 284 Alanine scans of IgE-binding to linear epitopes of Ara h 2 reveal min Gold, MD4, Margaret Collins, MD5, David Katzka, MD6, critical amino acids Gary Falk, MD, MS7, Lan. Lan, PhD8, Nirav Desai, MD8, James Nicole Canon, MD1, Catherine Schein, PhD2, Xueni Chen, MD3, Williams, MD8, Ikuo Hirano, MD9, Indiana University School of Marina Pozzoli3, Vidhya Pathy4, Stephen Dreskin, MD PhD Medicine, Riley Hospital for Children at Indiana University FAAAAI5, University of Colorado/National Jewish Health1, Uni- Health1, Cincinnati Children’s Hospital Medical Center2, Univer- versity of Texas Medical Branch2, University of Colorado - Den- sity of North Carolina at Chapel Hill3, Children’s Center for Diges- ver3, Choate Rosemary Hall4, University of Colorado Denver5 tive Healthcare, LLC, GI Care for Kids4, Cincinnati Children’s 284A Predicting Outcomes of Baked Egg and Baked Milk Oral Food Hospital Medical Center, University of Cincinnati College of Med- Challenges Using a Ratio of Food-Specific IgE to Total IgE icine5, Mayo Clinic6, University of Pennsylvania Perelman School Michelle Maciag, MD1, Brittany Esty, MD2, Lisa Bartnikas, MD1, of Medicine7, Shire, a Takeda company8, Northwestern University Carter Petty1, Andrew MacGinnitie, MD PhD FAAAAI1, Will Feinberg School of Medicine9 Sheehan, MD FAAAAI3, Wanda Phipatanakul, MD MS FAAAAI1, 292 Endotype and Phenotype Relationships in Children With Eosin- Boston Children’s Hospital1, Boston Children2, Children’s National ophilic Esophagitis Treated With Diet Elimination Medical Center3 Melissa Watts1, Rethavathi Janarthanam, PhD2, Ming Wang, MD3, Kaitlin Keeley, BS2, Joshua Wechsler, MD4, Northwestern Univer- sity1, Ann and Robert H. Lurie Children’s Hospital2, Ann and Rob- ert H Lurie Children’s Hospital3, Ann & Robert H. Lurie Children’s Eosinophilic Esophagitis Hospital4 285 Serum food-specific Immunoglobulin G4 (sIgG4) levels decrease 293 Active Eosinophilic Esophagitis is Associated with Increased after steroid treatment in Eosinophilic Esophagitis (EoE) Asthma Severity and Lower Lung Function in Children with Rung-chi Li, DO PhD1, Behnam Keshavarz, PhD1, Jeffrey Wilson, Comorbid Asthma 1 2 2 MD PhD1, Lisa Workman, BA1, Barrett Barnes, MD1, Bryan Sauer, Karyn Parsons , Katharine Guarnieri, MD , Dawit Tadesse, PhD , 2 2 MD, MSc1, Thomas Platts-Mills, MD PhD FAAAAI1, Emily Md Monir Hossain, MSc, PhD , Vincent Mukkada , Marc Rothen- 2 2 McGowan, MD PhD FAAAAI2, University of Virginia1, University berg, MD PhD FAAAAI , Theresa Guilbert, MD, MS , Sandy Dur- 2 1 of Virginia School of Medicin2 rani, MD , Wasatch Pediatrics , Cincinnati Children’s Hospital 2 286 Itch and Swallow – Atopic Dermatitis is Not Associated With an Medical Center/University of Cincinnati College of Medicine Increased Rate of Fibroses, Food Impaction and Stricture in Pa- 294 Integrative analysis of eosinophilic esophagitis genome-wide as- tients with Eosinophilic Esophagitis. sociation study single-nucleotide polymorphisms 1 1 1 Aparna Daley1, Pooja Jhaveri, MD1, Erik Lehman, MS2, Penn Melanie Ruffner, MD PhD , Margaret Carroll , Michele Meline , 1 1 State Health Milton S. Hershey Medical Center1, Penn State Kathleen Sullivan, MD, PhD , Zhe Zhang , Jonathan Spergel, MD, 1 1 University2 PhD , Patrick Sleiman, PhD , Children’s Hospital of 1 287 Characterization of Adults with Eosinophilic Esophagitis in Philadelphia British Columbia, Canada 295 Transgenic expression of secreted/active IL-33 results in type 2 Bei Yuan (Ethan) Zhang1, Lianne Soller, PhD2, Vishal Avinashi, immune responses and eosinophilic esophagitis 1 1 1 MD2, Edmond Chan, MD FAAAAI2, Hin Hin Ko1, University of Alfred Doyle, PhD , Mia Masuda, BS , Huijun Luo, PhD , Rish 1 1 1 British Columbia1, BC Children2 Pai, MD, PhD , Takao Kobayashi, PhD , Koji Iijima, PhD , Mat- 1 1 288 Outcomes in Pediatric vs. Adult Eosinophilic Esophagitis thew Rank, MD FAAAAI , Hirohito Kita, MD , Mayo Clinic 1 Susan Schuval, MD FAAAAI1, Deborah Boktor, MD2, Michelle Arizona J ALLERGY CLIN IMMUNOL Abstracts AB193 VOLUME 147, NUMBER 2

Epidemiology of Food Allergy 304 Clinical profile of limpet allergy: a preliminary report. Elena Mederos Luis1, Cristina Alava Cruz1, Ruperto Gonzalez 296 Differences in Diet Quality Among Food-Allergic Black and Perez, MD PhD1, Victor Matheu, MD, PhD1, Inmaculada Sanchez White Children 1 2 1 1 1 Machin , Paloma Poza Guedes, MD PhD , Hospital universitario de Eileen Vincent , Jialing Jiang , Jamie Fierstein, PhD , Alexandria 1 2 1 1 1 Canarias , Hospital Universitario de Canarias, Tene Bozen , Isabel Galic , Pamela Newmark , Christopher Warren, 305 Clinical Characterization of Chilean Patients with Food Pro- PhD1, Lucy Bilaver, PhD MS MA1, Jacqueline Pongracic, MD 2 3 3 tein-Induced Enterocolitis Syndrome FAAAAI , Annika Chura , Amal Assa’ad, MD FAAAAI , Aame 1 1 1 4 4 Francisca Moya , Barbara Cid , Ivana Ormazabal , Josefina Andy-Nweye , Susan Fox, PA , Mahboobeh Mahdavinia, MD 1 ~ 1 1 4 4 5 Cortes , Enzo Munoz , Arturo Borzutzky, MD FAAAAI , Rodrigo PhD FAAAAI , Mary Tobin, MD FAAAAI , Adam Robinson , 2 1 5 5 Hoyos , Pontificia Universidad Catolica de Chile , Pontificia Uni- Amaziah Coleman, MD , Hemant Sharma, MD, MHS , Andrea 2 6 1 versidad Catolica de Chile Pappalardo, MD FAAAAI , Ruchi Gupta, MD MPH , Northwest- 306 Impact of Socio-economic Status on IgE-mediated Food Allergy ern University Feinberg School of Medicine1, Ann & Robert H. 2 in Egyptian Children Lurie Children’s Hospital of Chicago , Cincinnati Children’s Hos- 1 1 3 4 Ahmed Elmazaly , Maged Refaat, MD FAAAAI , Amal Assa’ad, pital Medical Center , Rush University Medical Center , Children’s 2 1 1 5 6 MD FAAAAI , Mohamed Farris , Osama Abdel-latif , Manar Far- National Hospital , University of Illinois Hospital & Health ouk1, Ain Shams University1, Cincinnati Children’s Hospital Med- 297 The Racial and Ethnic Makeup of Food Allergy Immunother- ical Center2 apy Trials 307 Which Aspects Of Atopic Dermatitis Predict Peanut Allergy In Lauren Davidson1, Bridgette Jones, MD FAAAAI2, University of 1 2 Infancy? Missouri-Kansas City School of Medicine , Children Mansi Kotwal1, Michael Pistiner, MD MMSc2, Wayne Shreffler, 298 Symptoms of Allergic Reactions to Food via Breastmilk in In- MD PhD FAAAAI3, Robert Wood, MD4, Joan Dunlop, MD5, Jen- fants and Likelihood to Develop Tolerance 6 6 7 1 2 3 nifer Dantzer, MD , Mihaela Plesa , Daria Szelag, PNP , Roger Abigail Lang , Shrey Patel , Karen Rychlik, MS , Deanna Car- 6 8 4 5 Peng , Alkis Togias, MD FAAAAI , Corinne Keet, MD MS uso , Xiaobin Wang, MD MPH ScD , Jacqueline Pongracic, MD 9 1 6 6 PhD , Johns Hopkins Medical Center , MassGeneral Hospital for FAAAAI , Rajesh Kumar, MD FAAAAI , Lurie Children’s Hospi- 2 3 1 2 Children, Harva , Massachusetts General Hospital / Harvard , tal , University of Illinois at Urbana-Champaign , Biostatistics Re- 4 3 Johns Hopkins University School Medicine , Johns Hopkins Hospi- search Core, Stanley Manne Children’s Research Institute , 5 6 7 8 4 tal , Johns Hopkins , Johns Hopkins University , NIAID/NIH , University of North Carolina at Chapel Hill , Johns Hopkins Uni- 9 5 6 John Hopkins Hospital versity , Ann & Robert H. Lurie Children 308 Characteristics of Fish and Shellfish Allergy – Single Center 299 Sunflower Seed Allergy: A Case Series 1 1 1 Experience Celine Galleani , MC Dieguez , JF Crespo , 12 de Octubre 1 2 1 Irina Dawson, MD , Maria Chitty-Lopez, MD , Panida Sriaroon, Hospital MD FAAAAI2, Allergy Partners of Fredericksburg1, University of 300 Prevalence of Food Allergy Diagnosis in Moderate-Severe South Florida2 Atopic Dermatitis Pediatric Patients Referred to Allergy and/ 309 Frequency and Spectrum of Food Allergy Among Adult Pa- or Dermatology Subspecialty Clinics 1 1 1 tients with Allergic Rhinitis Related to Cross Sensitizations Jennifer Li, MD , Lisa Arkin, MD , Anne Marie Singh, MD , Uni- 1 1 1 1 Andrej Kurchenko , Vladyslav Tsaryk , Sergej Yuriev , Lawrence versity of Wisconsin-Madison Dubuske, MD FAAAAI2, Bogomolets National Medical University, 301 Evaluation of comorbid atopic diseases in pediatric patients Kyiv, Ukraine1, George Washington University School of Medicine, with multiple IgE-mediated food allergies 1 2 Washington, DC, USA; Immunology Research Institute of New Mosopefoluwa Lanlokun , Merritt Fajt, MD FAAAAI , University England, Gardner, MA, USA2 of Pittsburgh Medical Center; Children’s Hospital of Pittsburgh1, 2 310 Cross-reactivity Between Tree pollen, Food and Latex Allergens University of Pittsburgh Medical Center Viktoriia Rodinkova, PhD1, Valentyna Chopyak2, Serhii Yuriev3, 302 Characteristics of Adult-Onset Food Allergy Taras Gutor2, Olga Kaminska1, Lawrence Dubuske, MD FAAAAI4, Amanda McIntyre, MD1, Gayatri Patel, MD2, Joshua Wechsler, 3 4 National Pirogov Memorial Medical University, Vinnytsya, Uk- MD , Anne Marie Singh, MD , University of Wisconsin School 1 1 raine , Danylo Halytsky Lviv National Medical University, Lviv, of Medicine and Public Health, Madison, WI , Northwestern Fein- 2 2 Ukraine , Bohomolets National Medical University, Kyiv, Uk- berg School of Medicine, Chicago, IL , Ann & Robert H. Lurie raine3, George Washington University School of Medicine, Wash- Children’s Hospital, Northwestern Feinberg School of Medicine, 3 ington, DC, USA; Immunology Research Institute of New Chicago, IL , Northwestern Feinberg School of Medicine, Chicago, England, Gardner, MA, USA4 IL; University of Wisconsin School of Medicine and Public Health, 4 311 History of Eczema Among Black and White Peanut Allergic Madison, WI Children 303 Disparities of GERD treatment and Gastroenterology Care in Jialing Jiang1, Jamie Fierstein, PhD1, Lucy Bilaver, PhD MS MA1, Black Children with Food Allergy in FORWARD Cohort 1 1 1 1 2 3 Alexandria Bozen , Isabel Galic , Pamela Newmark , Christopher Mary Tobin, MD FAAAAI , Jamie Fierstein, PhD , Jialing Jiang , 1 2 4 5 Warren, PhD , Audrey Brewer, MD , Jacqueline Pongracic, MD Aame Andy-Nweye , Susan Fox, PA , Mahboobeh Mahdavinia, 2 3 3 4 6 FAAAAI , Annika Chura , Amal Assa’ad, MD FAAAAI , Aame MD PhD FAAAAI , Andrea Pappalardo, MD FAAAAI , Annika 4 4 7 8 9 Andy-Nweye , Susan Fox, PA , Mahboobeh Mahdavinia, MD Chura , Amal Assa’ad, MD FAAAAI , Adam Robinson , Hemant 4 4 5 9 9 PhD FAAAAI , Mary Tobin, MD FAAAAI , Adam Robinson , Sharma, MD, MHS , Amaziah Coleman, MD , Lucy Bilaver, 5 5 2 10 2 Amaziah Coleman, MD , Hemant Sharma, MD, MHS , Andrea PhD MS MA , Christopher Warren, PhD , Pamela Newmark , 6 1 3 11 Pappalardo, MD FAAAAI , Ruchi Gupta, MD MPH , Northwest- Alexandria Bozen , Jacqueline Pongracic, MD FAAAAI , Ruchi 1 12 ern University Feinberg School of Medicine , Ann & Robert H. Gupta, MD MPH , University Consultants in Asthma and Al- 2 1 2 Lurie Children’s Hospital of Chicago , Cincinnati Children’s Hos- lergy , Northwestern University , Northwestern University Fein- 3 4 3 4 pital Medical Center , Rush University Medical Center , Children’s berg School , Rush University Medical Center , Univ. National Hospital5, University of Illinois Hospital & Health6 Consultants in Allergy and Immunol5, University of Illinois Hospi- 6 7 312 ‘‘A sweet revenge’’: Pineapple-related adverse food reactions tal & Health , Cincinnati Children , Cincinnati Children’s Hospital 1 1 8 9 10 Zaimat Beiro , Mina Dimova, research associate , Ves Dimov, Medical Center , Children , University of Southern California , MD1, Cleveland Clinic Florida1 Ann & Robert H. Lurie Children11, Northwestern Medicine12 AB194 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2021

Food Allergy: Outcomes, Education, Delivery and Rachael Rosow1, Yamini Virkud, MD FAAAAI1, Victoria Martin, MD1, Wayne Shreffler, MD PhD FAAAAI2, Qian Yuan, MD PhD1, Quality Massachusetts General Hospital1, Massachusetts General Hospital / 313 Needs Assessment for an Infant and Toddler Food Allergy Cur- Harvard2 riculum for Pediatric Residents 324 Assessment of Anxiety, Depression and Resilience in Food-Al- Marielle Young1, Ariel Frey-Vogel, MD1, Kristina Dzara, PhD, lergic Adolescents and Primary Caregivers During the MMSc1, Michael Pistiner, MD MMSc2, MassGeneral Hospital for COVID-19 Pandemic Children1, MassGeneral Hospital for Children, Harva2 Ashton Rogers1, Emily Seminara2, Caitlan Murphy, MD3, Diana 314 Assessment Of Early Peanut Introduction Guidelines Among Munoz-Mendoza, MD4, Amika Sood, MD5, Ellen Manegold, Pediatricians In An Inner-city Hospital PhD3, Brandi Whitaker, PhD3, Stacie Jones, MD FAAAAI6, Amy Sumeet Sandhu, MD1, Monique Hanono, MD2, Carly Rabin, MD2, Scurlock, MD FAAAAI7, Arkansas Children’s Research Institute1, Rob Harriz, MD2, Sairaman Nagarajan, MD MPH1, Maria-Anna Arkansas Children’s2, UAMS3, University of Arkansas for Medical Vastardi, MD1, Center for Allergy and Asthma Research, SUNY Scien4, Arkansas Children5, UAMS/Arkansas Children6, UAMS/ Brooklyn Health Sciences University1, SUNY Downstate Medical AR Children’s Hospital7 Center2 315 A Quality Improvement Initiative to Improve Resident- Physi- cian Practices Regarding Flu Vaccine Administration in Indi- viduals with Egg Allergy Aishwarya Navalpakam1, Shweta Saini, MD1, Chi- Lan Tran2, Prevention and Management of Food Allergy Jenny Huang, MD1, Divya Seth2, Pavadee Poowuttikul, MD 325 Yellow Fever Vaccine in 435 Egg Allergic Children During FAAAAI2, Children’s Hospital of Michigan1, Wayne State 2018-2019 Yellow Fever Epidemic in Brazil University2 Wilson Rocha1, Fernanda Lopes1, Livia Oliviera1, Hospital Infantil 316 Dietary Normalization Following A Successful Oral Food Chal- Jo~ao Paulo II1 lenge In Children With Food Allergies 326 Screening for Anti-Food Immunoglobulin G of Human Plasma Elizaveta Rakhmanova, BSc1, Kuang-Chih Hsiao, MBChB2, Uni- and an Intravenous Immunoglobulin Preparation (Gammagard versity of Auckland School of Medicine, Auckland, New Zealand1, Liquid) Starship Hospital, Auckland District Health Board, Auckland, New Alfred Weber1, Andrea Engelmaier2, Baxalta Innovations Zealand2 GmbH, now part of Takeda1, Baxalta Innovation Gmbh, Member 317 Parental Perspectives on Food Allergy-Related Bullying/Teas- of Taked2 ing Screening Practices by Allergists and Pediatricians 327 Identification Is Key : Barriers To Regular Usage Of Allergy Dana O’Toole, MD1, Charlene Thomas1, Linda Gerber, PhD1, Identifiers Elizabeth Feuille, MD1, Edith Schussler, MD1, Lisa Bartnikas, Sebastian Sylvestre1, Doerthe Andreae, MD PhD1, Penn State Her- MD2, Perdita Permaul, MD FAAAAI1, Weill Cornell Medicine1, shey Medical Center1 Boston Children’s Hospital2 328 N-terminal Leader Sequence of Vicilin Storage Proteins Poten- 318 Systematic Development of a Patient-centered Outcomes Mea- tially Contribute to Cross-reactivity Between Evolutionarily sure to Assess the Psychosocial Impact of Food Allergy in Rou- Distant Plant Species. tine Clinical Practice Alexander Foo1, Jacqueline Nesbit, PhD2, Stephen Gipson3, Eu- Katherine Tison1, Kaitlin Proctor, PhD2, Hayley Estrem, PhD, gene DeRose1, Barry Hurlburt, PhD2, Soheila Maleki, PhD MSN, RN3, Jinhee Park, PhD, RN4, Brian Vickery, MD FAAAAI1, FAAAAI4, Geoffrey Mueller, PhD1, NIEHS1, USDA2, USDA William Sharp, PhD1, Emory University School of Medicine1, Cen- SRRC3, USDA-Agricultural Research Service4 ter for Advanced Pediatrics, Children’s Healthcare of Atlanta2, 329 Epinephrine Administration in Pediatric Patients with Food- UNCW School of Nursing3, Boston College4 Related Anaphylaxis 319 A Quality Improvement Initiative to Improve Resident-Physi- Isma Shah1, Benjamin Prince, MD MCSI FAAAAI1, cian Practices Regarding Peanut Introduction in Infancy Rebecca Scherzer, MD FAAAAI2, Elizabeth Erwin, MD2, Irene Mi- Shweta Saini, MD1, Chi-Lan Tran2, Jenny Huang, MD1, Divya khail, MD2, Nationwide Children’s Hospital1, Nationwide Seth1, Pavadee Poowuttikul, MD FAAAAI1, Children’s Hospital Children2 of Michigan, Detroit, MI1, Wayne State University School of Med- 330 Characteristics of Baked Cheese Challenge icine, Detroit, MI2 Jeehyun Rha1, Bruce Lanser, MD FAAAAI2, University of Colo- 320 Exploring psychosocial coping with food allergy rado/National Jewish Health1, National Jewish Health2 Lisa Lombard, PhD1, Gwen Holtzman, BA1, Madeleine Kanaley, 331 Providing Breast Milk to Infants and Toddlers with IgE-Medi- BA1, James Lawson1, Hannah Safron1, Ruchi Gupta, MD MPH2, ated Food Allergies Northwestern University1, Northwestern Medicine2 Hannah Wangberg, MD1, Kathleen Luskin, MD1, Samantha 321 Addressing food insecurities in clients with food allergies in un- Spierling Bagsic, PhD, MSE1, John Kelso, MD FAAAAI1, Cathleen derserved communities with a prescription food program Collins, MD2, Scripps Clinic1, University of California San Diego/ Andrea D’Mello, MD1, Amara Seng1, Marissa Love, MD1, Erin Rady Children’s Hospital2 Martinez, MS2, Emily Brown2, University of Kansas Medical Cen- 332 Time To Resolution Of Egg Allergy Utilizing A Baked Egg Diet: ter1, The Food Equality Initiative2 A Community-Based Practice Analysis 322 The impact of COVID-19 on patients with food protein-induced Jeff Zavala, Resident1, Erin Rasmussen, MD1, University of enterocolitis syndrome (FPIES) and their caregivers. Iowa1 Brit Trogen, Hope Jin, MD1, Antonella Cianferoni, MD PhD 333 Early Anticipatory Guidance and Sensitization to Tree Nuts in FAAAAI2, Fallon Schultz, MSW, LCSW, CAM3, Amity Chavez4, At-risk Infants Anna Nowak-Wegrzyn, MD, PhD1, NYU Langone Health1, Chil- Priyanka Seshadri, MD1, Sharon Hwang, MD2, Trong Le, MD3, dren2, FPIES3, Int4 Thomas Jefferson University Hospital1, Nemours AI DuPont Hospi- 323 Early Growth in Children with IgE and Non-IgE-Mediated tal for Children2, Nemours/Sidney Kimmel Medical College Food Allergy in a Healthy Infant Cohort Th3 J ALLERGY CLIN IMMUNOL Abstracts AB195 VOLUME 147, NUMBER 2

Treatment of Food Allergy 341 Non-Daily OIT Dose Frequency may be Safe and Effective Whitney Block1, Barrie Shapiro, PhD1, Teresa Neeno, MD1, Na- 334 Do Age and Baseline Peanut-specific IgE Levels Predict Oral tional Allergy Center1 Immunotherapy Outcomes? 342 Reduction in Severity Following 12 Months of Epicutaneous Im- Katharine Guarnieri, MD1, Ian Slack, MD1, Amy Eapen, MD, 1 2 1 munotherapy for Peanut Allergy MS , Vanessa Gadoury-Levesque, MD , Sandra Andorf, PhD , Mi- 1 1 1 Philippe Begin, MD FAAAAI , Universite de Montreal chelle Lierl, MD FAAAAI , Cincinnati Children’s Hospital Medical 343 Real World Adoption of FDA-approved Peanut Oral Immuno- Center/University of Cincinnati College of Medicine1, Montreal 2 therapy with Palforzia Children’s Hospital/McGill University S Shahzad Mustafa, MD1, Sara Patrawala, MD2, Rochester Re- 335 Safety of Peanut (Arachis Hypogaea) Allergen Powder-dnfp in gional Health1, University of Rochester Medical Center2 Children and Teenagers With Peanut Allergy: Pooled Analysis 344 Mass Cytometry Reveals Immune Signatures Associated With From Controlled and Open-Label Phase 3 Trials 1 2 Desensitization Through Multi-Food Oral Immunotherapy. Thomas Casale, MD FAAAAI , A. Wesley Burks, MD FAAAAI , 1 1 1 1 3 4 Ziyuan He , Diane Dunham , Xiaoying Zhou , Shu-Chen Lyu , James Baker, MD FAAAAI , Jonathan O’B Hourihane , Kirsten 1 1 5 6 Monali Manohar, PhD , Sharon Chinthrajah, MD , Sandra Andorf, Beyer, MD , Brian Vickery, MD FAAAAI , Stacie Jones, MD 2 3 7 8 PhD , Kari Nadeau, MD PhD FAAAAI , Stanford University FAAAAI , George Du Toit, MD FAAAAI , J. Andrew Bird, MD 1 9 10 10 School of Medicine , University of Cincinnati College of Medicine; FAAAAI , Alex Smith , Kari Brown, MD , Stephen Tilles, 2 10 1 Cincinnati Children’s Hospital Medical Center , Stanford Univ MD , University of South Florida, Tampa, FL, USA , University School Medicine3 of North Carolina Food Allergy Initiative, Division of Allergy, Im- 345 Oral Immunotherapy in Children with Peanut Allergy and munology and Rheumatology, University of North Carolina at 2 Asthma in Clinical Practice Chapel Hill, Chapel Hill, NC, USA , Mary H Weiser Food Allergy 1 1 1 3 Adam Magier, MS , Sandra Andorf, PhD , Christa Mills, RN , Center, University of Michigan, Ann Arbor, MI, USA , Paediatrics Sandy Durrani, MD2, Justin Schwartz, MD PhD2, Cincinnati Chil- and Child Health, Royal College of Surgeons in Ireland, Dublin, dren’s Hospital Medical Center1, Cincinnati Children’s Hospital Ireland4, Charite Universt~atsmedizin Berlin, Berlin, Germany5, 6 Medical Center. University of Cincinnati College of Medicine. Cin- Emory University School of Medicine, Atlanta, GA, USA , Univer- cinnati OH USA2 sity of Arkansas for Medical Sciences and Arkansas Children’s 346 Microarray Analysis of Major Epitopes Among Tree Nut-Aller- Hospital, Little Rock, AR, USA7, Guy’s and St. Thomas’ NHS 8 gic Individuals May Explain Patterns of Cross-Desensitization Foundation Trust, London, United Kingdom , Department of Pedi- Stephen Gipson1, Jacqueline Nesbit, PhD1, Hsiaopo Cheng1, Su- atrics, Division of Allergy and Immunology, University of Texas 2 9 zanne Teuber, MD FAAAAI , Stephen Dreskin, MD PhD Southwestern Medical Center, Dallas, TX, USA , Aimmune Ther- 3 4 1 10 FAAAAI , S Shahzad Mustafa, MD , Barry Hurlburt, PhD , So- apeutics, Brisbane, CA, USA heila Maleki, PhD FAAAAI1, USDA SRRC1, Univ CA-Davis 336 Predefined Clinical and Laboratory Criteria Predict Successful School of Medicine2, University of Colorado Denver3, Rochester Transition from Peanut Oral Immunotherapy Daily Mainte- Regional Health4 nance Dosing to Ad Lib Consumption 347 Continuing Peanut Oral Immunotherapy via Telemedicine Dur- Ian Slack, MD1, Katharine Guarnieri, MD1, Amy Eapen, MD, 1 2 1 ing the COVID-19 Pandemic MS , Vanessa Gadoury-Levesque, MD , Sandra Andorf, PhD , Mi- 1 2 1 Anna Schoonover , Anny Uyehara, NP , Michael Goldman, MD chelle Lierl, MD FAAAAI , Cincinnati Children’s Hospital Medical 3 1 1 FAAAAI , Allergy and Asthma Center of Central Mar , Allergy Center/University of Cincinnati College of Medicine , Montreal 2 2 & Asthma Center of Central Maryland , Allergy & Asthma Center Children’s Hospital/McGill University of Central Maryl3 337 Tolerance of Pistachio and Pecan in Patients Desensitized to 348 Biomarkers for Desensitization in Patients Undergoing Sublin- Cashew and Walnut 1 gual Immunotherapy for Peanut Allergy Madison Lee, Jeffrey Factor, MD , CT Asthma and Allergy Center, 1 2 3 1 Suzanne Barshow , Barry Hurlburt, PhD , Jane McBride, MS , LLC Soheila Maleki, PhD FAAAAI2, Ping Ye4, Quefeng Li, PhD5,A. 338 Identifying Candidates for Real-World Peanut Oral Immuno- Wesley Burks, MD FAAAAI4, Michael Kulis, PhD4, Edwin Kim, therapy in the Allergy Clinic 4 1 MD MS FAAAAI , Duke University Medical Center; University Andrea Blackman, MD , Aikaterini Anagnostou, MD MSc PhD 1 2 2 1 of North Carolina- Chapel Hill , USDA , USDA Agricultural Re- FAAAAI , Baylor College of Medicine, Texas Children’s Hospital , 3 4 2 search Service , University of North Carolina- Chapel Hill , Uni- Texas Children versity of North Carolina-Chapel Hill5 339 Identification and modulation of the peripheral innate lym- 349 A positive perception of treatment and continued adherence to phoid cells type 2 in LTP-allergic patients treated with Pru p dosing in a long-term follow-up study in food allergic partici- 3 Sublingual Immunotherapy. 1 2 pants undergoing multi-food oral immunotherapy Maria Francisca Palomares Jerez, PhD ,FranciscaGomez, Sayantani Sindher, MD1, Divya Kumar, PhD1, Jessica Fitzpa- 3 1 ~ 4 Gador Bogas ,Marıa JoseRodrıguez ,RosaMunoz-Cano , trick1, Shu Cao1, Andrew Long, PharmD2, Margaret Woch1, Tiffany 3 5 Marıa JoseTorres, Cristobalina Mayorga, PhD ,Allergy Conn1, Kari Nadeau, MD PhD FAAAAI3, Sharon Chinthrajah, Research Group, Instituto de Investigacion Biomedica de MD1, Stanford University - Sean N. Parker Center for Allergy 1 Malaga-IBIMA, Malaga, Spain , Allergy Clinical Unit, Hospital and Asthma Research1, Stanford University2, Stanford Univ School 2 Regional Universitario de Malaga, Malaga, Spain ,Allergy Medicine3 Clinical Unit, Hospital Regional Universitario de Malaga, 350 Adverse Reactions and Anaphylactic Adverse Reactions 3 Malaga, Spain , Allergy Section, Institut Clınic Respiratori Among Children Undergoing Milk Oral Immunotherapy 4 (ICR), Hospital Clınic de Barcelona, Barcelona, Spain ,Allergy (OIT) Research Group, Instituto de Investigacion Biomedica de Luca Delli Colli1, Sofianne Gabrielli, MSc2, Bruce Mazer, MD 5 Malaga-IBIMA, Malaga, Spain FAAAAI3,DanbingKe,PhD4, Christine McCusker, MD MSc5, 340 Subcutaneous Immunotherapy for Pollen Food Allergy Syn- Liane Beaudette, RN6, Duncan Lejtenyi, MSc1,EdmondChan, drome: A Systematic Review 7 7 8 1 1 1 MD FAAAAI ,IngridBaerg,EyalGrunebaum,MD, Philippe Abigail Finley , Evan Atkinson, MD MS , Tulane University Begin, MD FAAAAI9,AnnClarke10,MosheBen-Shoshan,MD AB196 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2021

FAAAAI5, McGill University Health Center1, McGill University 360 COVID-19 Impact on Participant Engagement with a School- Health Centre2, The McGill University Health Center3,McGill centered Asthma Navigator Program University Health Center Research4, Montreal Children5,McGill6, Melanie Gleason, MS PA-C1, Arthur McFarlane2, Mfonobong BC Children7, Hospital for Sick Children8, Universite de Mon- Udoko, MD1, Elizabeth Konon3, Stanley Szefler, MD FAAAAI1, treal9, University of Calgary10 University of Colorado School of Medicine/Children’s Hospital 351 Protease-digested Egg White Products Induce Oral Tolerance, Colorado1, Children’s Hospital Colorado2, University of Colorado but Little IgE Production upon Epicutaneous Exposure in Mice School of Medicine3 Ayako Yamada1, Takanori Hasegawa, PhD1, Hideaki Morita, MD 361 Changes in food spending among food allergic families follow- PhD2, Kenji Matsumoto, MD PhD2, NH Foods Ltd.1, National Re- ing the COVID-19 pandemic search Institute for Child Health and Development2 Michael Golding1, Catherine Lemoine-Courcelles, BSc1, Elissa 352 A Simplified, Real-World Approach to Safely Inducing Bite-Proof Abrams, MD FRCPC1, Moshe Ben-Shoshan, MD FAAAAI2, Ed- Tolerance in Peanut-Allergic Preschool-Aged Children and Babies. mond Chan, MD FAAAAI3, Derek Chu, MD PhD4, Jennifer Sandra Hong, MD FAAAAI1, Alice Hoyt, MD1, Rachel Whitsel, Gerdts5, Harold Kim, MD6, Elinor Simons, MD PhD MS CNP1, Jaclyn Bjelac, MD2, Ahila Subramanian1, Cleveland Clinic Foun- FAAAAI1, Julia Upton, MD7, Jennifer Protudjer, PhD1, University dation1, Cleveland Clinic2 of Manitoba1, McGill University2, University of British Columbia3, McMaster University4, Food Allergy Canada5, Western University6, The Hospital for Sick Children7 COVID-19 and The Virtual Allergy Office 362 Consequences of the COVID-19 pandemic on grocery shopping habits of food allergic families 353 Retrospective Analysis of Synchronous Telemedicine Use in Michael Golding1, Catherine Lemoine-Courcelles, BSc1, Elissa Clinical Immunology and Allergy (CIA): A Population-based Abrams, MD FRCPC2, Moshe Ben-Shoshan, MD FAAAAI3,Phil- Cohort Study in Ontario, Canada 4 5 1 2 2 ippe Begin, MD FAAAAI ,EdmondChan,MDFAAAAI, Derek Erika Lee , Christine Song, MD , Peter Vadas, MD PhD , Matthew 6 7 8 3 1 1 Chu, MD PhD , Jennifer Gerdts ,HaroldKim,MD, Elinor Simons, Morgan, MD , Stephen Betschel , University of Toronto , St. Mi- 2 9 2 2 3 MD PhD MS FAAAAI ,JuliaUpton,MD, Jennifer Protudjer, PhD , chael , Sinai Health System University of Manitoba; Children’s Hospital Research Institute of 354 Patient’s perceived quality and satisfaction of Teleconsultation Ser- Manitoba1, University of Manitoba2, Montreal Children3, Universite vices in an Allergy Department during COVID-19 pandemic era. 4 5 6 1 1 de Montreal ,BCChildren, McMaster University , Food Allergy Aida Bermejo-Becerro , Filip Skrabski, Allergologist , Esperanza Canada7, Western University8, The Hospital for Sick Children9 Perez-Pallise1, Sandra Rodrıguez-Hermida1,Jose Manuel Zubeldia1, 1 363 Understanding the impact of the COVID-19 pandemic on phys- Alberto Alvarez-Perea , Hospital General Universitario Gregorio ical and mental health ~ 1 Maranon Shu Cao1, Hena Din1, Christopher Warren, PhD1, Jessica Fitzpa- 355 Rapid Adoption of Video Visits and Return-to-Clinic Proce- trick1, Tina Hernandez-Boussard2, Manisha Desai, PhD3, Sharon dures to Maintain Access to Allergy/Immunology Care Delivery Chinthrajah, MD1, Kari Nadeau, MD PhD FAAAAI4, Stanford Uni- During COVID-19 1 1 1 versity - Sean N. Parker Center for Allergy and Asthma Research , Lulu Tsao, MD , Stephanie Anne Villanueva Ferraris, RN , David Stanford University - Biomedical Data Science and of Surgery2, Pines1, Eugene Choo, MD FAAAAI1, Michele Pham, MD1, Monica 1 1 1 Stanford University - BIOMEDICAL DATA SCIENCE AND, BY Tang, MD , Lorianna Leard, MD , Andrew Gross, MD , Cameron 3 1 1 1 COURTESY, OF HEALTH RESEARCH AND POLICY , Stanford Ashbaugh, MD , Lei Choi, MD , Iris Otani, MD FAAAAI , 4 1 Univ School Medicine UCSF 364 The Emotional Impact of COID-19 on Residents and Fellows 356 How To Care For Errors of Innate Immunity (EII) Patients Muhammad Awan1, Kristina Antuna, MD1, Nova Southeastern During The Pandemic In a Developing Country Without Tele- University1 medicine? 365 A COVID-19 vaccine success? patients perception of Covid vac- Raissa Roque, MD1, Fernanda Vaz, MD2, Rafael Saldanha3, Caro- 4 5 1 cination program line Ferreira, MD , Nathalia Vital, MD , Pedro Bubach , Mariana Wardha. Wardha, Bsc1, Vaidehi Bhatt, BSc1, Tyler Seto1, Vince 6 ~ 1 1 Pimentel , Rafaela Guimaraes , Luiza Schmid , Candida Rizzo, Wu, BSc1, Hamilton Allergy1 MD PhD7, Carolina Aranda5, Dirceu Sole1, Federal University of S~ao Paulo1, FEDERAL UNIVERSITY OF SA~f O PAULO2, Univer- sidade Federal de SA~£o Paulo3, UNIFESP- Federal University of ~ 4 5 SA£oPau, Federal University of Sao Paulo , Federal University Epidemiology of SA~£o Paulo6, UNIFESP7 357 Covid impact in allergy: patients’ perceptions of ‘‘virtual’’ con- 366 Bioinformatic analysis of electronic birth cohort reveals distinct sultations and preferences for the future. associations between early-life environmental factors and child- Vince Wu, BSc1 1 1 hood allergic outcomes , Wardha. Wardha, Bsc , Vaidehi Bhatt, BSc ,Ty- 1 1 ler Seto1, Hamilton Allergy1 Stanislaw Gabryszewski, MD PhD , Jesse Dudley, MS , Robert Grundmeier, MD2, David Hill, MD, PhD3, Children’s Hospital of Philadelphia, Philadelphia, PA1, Children’s Hospital of Philadel- phia, Philadelphia, PA2, Children’s Hospital of Philadelphia; Uni- COVID-19 Related Behavior and Outcomes versity of Pennsylvania, Philadelphia, PA3 358 Increased adherence to controller medication maintained dur- 367 Neonatal Intensive Care Unit Demographics and Subsequent ing the COVID-19 pandemic Development of Food Allergies Benjamin Theye1, Leanne Kaye2, Jared Nagano1, Rahul Gondalia, Emily Robbins1, Seleshi Demissie, PhD1, Jonathon Blau, MD1, PhD2, Meredith Barrett, PhD2, David Stempel, MD FAAAAI1, Pro- Courtney Briggs-Steinberg, DO1, Staten Island University peller Health1, ResMed2 Hospital1 359 Allergy & Immunology Involvement on Multidisciplinary 368 The Association Between Family History of Atopy and Food Al- Treatment Team During COVID-19 Pandemic lergy in Hispanic Children Veronica Azmy, MD1, Kelsey Kaman, MD1, Christina Price, MD1, Stephania Lairet, MD1, Stanislav Ivanov, MD2, Jose Calderon, Yale School of Medicine1 MD1, Vivian Hernandez-Trujillo, MD FAAAAI3, Nicklaus J ALLERGY CLIN IMMUNOL Abstracts AB197 VOLUME 147, NUMBER 2

Children’s Hospital1, University of Miami/JFK Medical Center2, MD, MHS2, Linda Herbert, PhD2, NIH1, Children’s National Allergy and Immunology Care Center of So3 Hospital2 369 Characterization of the Relationship Between Prenatal Farm 378 Weekly and Seasonal Variation in Controller Adherence by Age Exposures and Allergen Sensitization in the First Year of Life in Asthma Joshua Brownell1, Zhumin Zhang1, James Gern, MD2, Christine Leanne Kaye, Rahul Gondalia, PhD1, Meredith Barrett, PhD1, Seroogy, MD FAAAAI1, University of Wisconsin1, University of Bruce Bender, PhD FAAAAI2, David Stempel, MD FAAAAI3, Re- Wisconsin-Madison2 sMed1, National Jewish Health2, Propeller Health3 379 Study on Allergy to Beta-lactams. Should all the patients be de- labeled? Marıa Dolores Rodrıguez Bote1, Leticia Domınguez-Cereijo2, Health Information and Technology Amparo Conde-Alcaniz~ 2, Pedro Guardia-Martınez2, Virgen Macar- 370 Remote Data Collection Through the ASTHMAXcel Mobile ena University Hospital (HUVM), Seville, Spain1, Virgen Macarena Application, and Lessons Learned During the COVID-19 Pan- University Hospital (HUVM), Seville, Spain2 demic 380 Combatting Inappropriate Allergy Alert Overrides Brian Hsia, MD1, Anjani Singh, MD2, Obumneme Njeze, BS2, Soombal Zahid1, Annette Piotrowski1, Lenox Hill Hospital-North- Emine Cosar2, Savneet Kaur2, Sunit Jariwala, MD FAAAAI3, Icahn well Health1 School of Medicine at Mount Sinai1, Montefiore Medical Center2, 381 Influenza Vaccination of High Risk Brooklyn Residents Ques- Albert Einstein/Montefiore Medical Cente3 tionnaire 371 Human dietitians vs. Artificial intelligence: Which diet design Venkatesh Sabhae Gangadharappa1, Rauno Joks, MD FAAAAI2, do you prefer for your children? SUNY Downstate Medical Center1, SUNY-HSC2 Min Jung1, Chiehyeon Lim2, Changhun Lee2, Soohyeok Kim2, 382 Risk of Postmarket Black Box Warnings in FDA Approved Jayun Kim3, Kosin Gospel University Hospital, Busan, Korea1, Ul- Monoclonal Antibodies san National Institute of Science and Technology (UNIST), Ulsan, John Hagan1, Elizabeth Ender, MD2, Rohit Divekar, MBBSPhD1, Korea2, Kosin University Gospel Hospital, Busan, Korea3 Thanai Pongdee, MD FAAAAI1, Nilay Shah3, Matthew Rank, MD 372 Mapping Food Allergy Data to a Standard Data Model FAAAAI4, Mayo Clinic1, Marshfield Medical Center2, Mayo Mark Wlodarski, MS1, Ruchi Gupta, MD MPH2, Lucy Bilaver, Clinic, Rochester3, Mayo Clinic and Foundation4 PhD MS MA3, Shruti Sehgal, MD(Hom), MS4, Justin Starren, 383 The Impact of Education on Health Literacy of Asthmatics in MD, PhD, FACMI5, Michael Gurley, BA5, Firas Wehbe, MD, the Bronx PhD5, Northwestern University, Feinberg School of Medicine1, Obumneme Njeze, BS1, Brian Hsia, MD2, Anjani Singh, MD1, Northwestern Medicine2, Northwestern University3, Northwestern Emine Cosar1, Savneet Kaur1, Sunit Jariwala, MD FAAAAI1, Al- University, Feinberg School4, Northwestern University Feinberg bert Einstein College of Medicine/Montefiore Medical Center1, School of Medicine5 Mount Sinai Hospital2 373 Lacking Demographic, Socioeconomic, and Environmental Var- 384 Applying a Symptom Scorecard to the Management of Pre- iables in Training Machine Learning Algorithms Makes Gener- sumed or Confirmed Mast Cell Activation Syndrome alizability Flawed in Asthma Studies Onyinye Iweala, MD PhD1, Claire Amelio, RN, BSN1, Emily Chen1, Timothy Darby1, Sunit Jariwala, MD FAAAAI2, Al- Mildred Kwan, MD PhD FAAAAI1, University of North bert Einstein College of Medicine1, Albert Einstein/Montefiore Carolina1 Medical Cente2 385 Design of a Mast Cell Activation Syndrome Symptom Score- 374 The Development and Validation of Food Allergy Data Dictionary card ShrutiSehgal,MD(Hom),MS1, Ruchi Gupta, MD MPH2,Mark Claire Amelio, RN, BSN1, Mildred Kwan, MD PhD Wlodarski, MS1,LucyBilaver,PhDMSMA2, Melanie Makhija, FAAAAI1, Onyinye Iweala, MD PhD1, University of North MD3, Jonathan Spergel, MD, PhD4, Julie Wang, MD FAAAAI5, Carolina1 Christina Ciaccio, MD FAAAAI6, Dana Ward, MS, MBA7, Nicholas 386 Practice improvement module variability among care providers 1 Soulakis, PhD1, Justin Starren, MD, PhD, FACMI1, Northwestern Uni- Aaron Case , Thomas Casale, MD FAAAAI2, Sharmilee Nyen- versity, Feinberg School of Medicine, Chicago, IL1,NorthwesternUni- huis, MD FAAAAI1, University of Illinois at Chicago1, University versity, Feinberg School of Medicine, Chicago, IL; Ann & Robert H. of South Florida2 Lurie Children’s Hospital of Chicago, Chicago, IL2,Ann&RobertH. 387 Creation of a Novel Shared Decision-Making Tool in Pediatric Lurie Children’s Hospital of Chicago, Chicago, IL3, Children Hospital High-Risk Asthma Clinic 1 2 of Philadelphia4, Icahn School of Medicine at Mount Sinai5,TheUni- Christina Huddleston , Kirsten Kloepfer, MD MS FAAAAI , Na- 3 2 4 versity of Chicago6, Food Allergy Research & Education (FARE)7 dia Krupp, MD , James Slaven, MS, MA , Cindy Fiscus, RN , Ka- 375 A Retrospective Study of Risk Factors for Redocumentation of thryn Treadwell, RN4, Riley Children’s Hospital, Indiana Penicillin Allergy University School of Medicine1, Indiana University2, Indiana Uni- Alexander Horbal1, Sunjay Modi, MD1, Alexandra Sitarik2, Bin versity School of Medicine3, Riley Children4 Liu3, Haejin Kim, MD2, Edward Zoratti, MD FAAAAI1, Henry 388 Evaluating Clinical Outcomes and Impact of a Pharmacist- Ford Hospital1, Henry Ford Health System2, Henry Ford Health managed Asthma Clinic Systems3 Ikjae Chin, Healthcare Economics and Disparities

Healthcare Behavior, Education and Outcomes Healthcare Economics and Disparities 376 Quality Improvement: Enhancing Asthma Control Test Docu- 389 Reducing Disparities in Asthma & Atopic Dermatitis – The Pa- mentation via Smarter EMR Integration. tient Experience Omar Waqar, MD1, Mauli Desai, MD1, Icahn School of Medicine Tonya Winders1, Erica Gonzalez-Reyes1, Allergy & Asthma at Mount Sinai1 Network1 377 Systematic Food Allergy Educational Resource Evaluation by 390 School-Based Asthma Education Intervention is Associated Caregivers of Children with Food Allergy with Improved Asthma Knowledge in Spanish bi-lingual chil- Stephanie Kubala1, Ashley Ramos, PhD2, Hemant Sharma, dren with asthma AB198 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2021

Margee Louisias, MD MPH1, Wanda Phipatanakul, MD MS University of Chicago, Chicago, IL, USA6, Ghent University Hos- FAAAAI2, Brigham and Women’s Hospital1, Boston Children’s pital, Ghent, Belgium7, GSK, Brentford, London, UK8, GSK, Res- Hospital2, piratory Triangle Park, NC, USA9, GSK, Stevenage, UK10 400 Peer Relationships in Children with Food Allergies Christian Coletta1,KishaRadliff2, Benjamin Prince, MD MCSI FAAAAI1, Rebecca Scherzer, MD FAAAAI3, Irene Mikhail, MD3, Quality Improvement Nationwide Children’s Hospital1, The Ohio State University College 391 Improving Influenza Immunization Rates of Education and Human Ecology2, Nationwide Children3 Jun Mendoza, James Quinn, MD FAAAAI1, Wilford Hall1 401 MassGeneral Hospital for Children Food Allergy Buddies 392 Allergists Should Be Proficient In Providing Comprehensive Program: A Multidisciplinary Community Mentorship Program Care For Patients With Alpha-1 Antitrypsin Deficiency Maria Theodorakakis, PhD, psychologist1, Mharlove Andre, BA1, 1 1 Anna Ptasinski , Timothy Craig, DO FAAAAI , Penn State Michael Pistiner, MD MMSc2, Massachusetts General Hospital1, 1 University MassGeneral Hospital for Children, Harvard Medical School2 393 Association of Chronic Diseases with Penicillin Allergy Status– 402 Mepolizumab reduces disease symptoms for Patients with A Retrospective Study Chronic Rhinosinusitis with Nasal Polyps: Data from the SYN- Paul Faybusovich, DO1, Maria Paula Henao, MD1, Taha Al- APSE study 1 1 Shaikhly, MBChB , Penn State College of Medicine Maggie Tabberer, MSc1, Andrew Trigg, MSc2, William Busse, 394 Identifying and overcoming barriers to inpatient Penicillin al- MD FAAAAI3, Valerie Lund, MB BS, MS, FRCS, FRCSEd4, Jason lergy de-labeling by non-allergists. Lee, MD FAAAAI5, Claus Bachert, MD PhD6, Brent Senior, MD7, 1 1 Cheryl Rozario , Jessica Stern, MD , University of Rochester Kathleen Buchheit, MD8, Zuzana Diamant, MD PhD9, Ana Sousa, 1 Medical Center PhD10, Steven Smith, PhD MSc11, Bhabita Mayer, MSc1, Steven Yancey, MS MBA12, Robert Chan, MD13, GSK, Stockley Park, Ux- bridge, Middlesex, UK1, Adelphi Values Ltd, Manchester, UK2, University of Wisconsin, Madison, Wisconsin, USA3, University Quality of Life 4 College London, London, UK , Toronto Allergy and Asthma 395 Development and Initial Validation of a Food Allergy Associ- Clinic, Toronto, ON, Canada5, Ghent University and Ghent Univer- ated Parental Anxiety Screening Tool: IMPAACT sity Hospital, Ghent, Belgium6, University of North Carolina, 1 2 Sharon To , Clara Westwell-Roper, MD, PhD , Lianne Soller, Chapel Hill, NC, USA7, Brigham and Women’s Hospital, Boston, 3 4 2 PhD , Edmond Chan, MD FAAAAI , S. Evelyn Stewart, MD , De- MA, USA8, Skane University Hospital, Lund University, Lund, partment of Psychology, BC Children’s Hospital, Vancouver, BC, Sweden9, GSK, Stockley Park, Uxbridge, UK10, GSK, Research 1 2 Canada , Department of Psychiatry, Faculty of Medicine, UBC , Triangle Park, NC, USA11, GSK, Respiratory Triangle Park, NC, Division of Allergy and Immunology, Department of Pediatrics, USA12, GSK, Stevenage, UK13 3 Faculty of Medicine, UBC, Vancouver, , Division of Allergy and 403 The Food Allergy Parent Mentoring Program: A novel interven- Immunology, Department of Pediatrics, Faculty of Medicine, tion for parents of children with newly diagnosed food allergies 4 UBC, Vancouver, BC, Canada Ashley Ramos, PhD1, Frances Cooke, BA1, Emily Miller, BS1, 396 Quality Of Life Comparison Between Proactive And Reactive Linda Herbert, PhD1, Children’s National Health System1 Therapy In Children With Atopic Dermatitis Yuri Endo1, Kenji Toyokuni1, Kiwako Yamamoto-Hanada, MD PhD1, Yukihiro Ohya, MD PhD2, National Center for Child Health and Development1, National Center for Child Health and Dev2 Advances in Immunotherapy 397 Quality of Life in Food Allergic Children and Adolescents at a 404 Efficacy and Safety of Subcutaneous Immunotherapy for Aller- Community Educational Symposium gic Asthma with Summer and Autumn Pollen Mixed Allergen Diem-Tran Nguyen, MD1, Kathleen Pitts, PhD, APRN, PNP-BC, Extract MPH1, Kristen Staggers, MS1, Carla Davis, MD1, Baylor College Zhirong Du1, Jia Yin1, Lun Li1, Peking Union Medical College of Medicine1 Hospital1 398 The clinically important impact of preschool food oral immuno- 405 Moving Forward In Health Disparities: Aqueous Intradermal therapy on parental quality of life Immunotherapy Rishma Chooniedass1, Lianne Soller, PhD1, Sandeep Kapur, MD2, Arnaldo Capriles Hulett1, CINTHYA RONDON, MD2, Hospital Gregory Rex, MD2, Mary McHenry, MD2, Timothy Vander Leek, San Juan de Dios1, HOSPITAL SAN JUAN DE DIOS , CARACAS, MD FAAAAI3, Raymond Mak, MD1, Tom Gerstner, MD4, Stuart VENEZUELA2 Carr, MD FAAAAI3, Edmond Chan, MD FAAAAI1, University 406 Novel dose-adjustment protocol for subcutaneous immunother- of British Columbia1, Dalhousie University2, University of Al- apy interruption berta3, University of Manitoba4 Denise Sanchez Tejera1, David Rosenstreich, MD FAAAAI2, 399 Mepolizumab Improves Health Related Quality of Life for Pa- Golda Hudes, MD PhD3, Denisa Ferastraoaru, MD4, Elina Jer- tients with Chronic Rhinosinusitis with Nasal Polyps: Data from schow, MD FAAAAI2, Merhunisa Karagic5, Sunit Jariwala, MD the SYNAPSE study FAAAAI6, Manish Ramesh, MD PhD3, Albert Einstein College Stella Lee, MD1, Maggie Tabberer, MSc2, Andrew Trigg, MSc3, of Medicine/ Montefiore Medical Center1, Albert Einstein College Joseph Han, MD FAAAAI4, Wytske Fokkens, MD PhD5, Robert of Medicine2, Montefiore Medical Center3, Albert Einstein College Naclerio, MD FAAAAI6, Philippe Gevaert, MD7, Ana Sousa, of Medicine/Mont4, Montefiore Medical Center/Albert Einstei5, Al- PhD2, Peter Howarth, MD8, Bhabita Mayer, MSc2, Steven Yancey, bert Einstein/Montefiore Medical Cente6 MS MBA9, Robert Chan, MD10, University of Pittsburgh School of 407 An Exploratory Field Study With A Subcutaneously Adminis- Medicine, Pittsburgh, Pennsylvania, USA1, GSK, Stockley Park, tered Tyrosine Adsorbed Modified Grass Allergen + MPL Uxbridge, Middlesex, UK2, Adelphi Values Ltd, Manchester, Pieter-Jan de Kam, PhD MBA1, Stefan Zielan2, Kemi Oluwayi, UK3, Eastern Virginia Medical School, Norfolk, VA, USA4, Am- MD1, Marion Seybold1, Murray Skinner3, Allergy Therapeutics1, sterdam University Medical Centres, Location AMC Amsterdam, Goethe University, Frankfurt, Germany2, Allergy Therapeutics, Amsterdam, The Netherlands5, Pritzker School of Medicine, PLC3 J ALLERGY CLIN IMMUNOL Abstracts AB199 VOLUME 147, NUMBER 2

408 Review of Anaphylaxis Associated with Subcutaneous Immuno- Fernando Pineda de la Losa, PhD1, Ruperto Gonzalez-Perez2, therapy in a Single Allergy Center Miriam Castillo3, Paloma Poza-Guedes, MD, PhD4, E. Mederos- Nerissa D’Silva, MD1, Walaa Hamadi, MD1, Aurora Moberly1, Luis4, C. Alava-Cruz4, Victor Matheu, MD, PhD4, Inmaculada Ashley Snyder, MPH1, Zach Ney1, Jeanna Ryan, PA-C1, Hannah Sanchez-Machin4, DIATER Laboratorios, Madrid. Spain1, Univer- Duffey, MD1, University of Utah1 sitary Hospital of Canary Islands, Santa Cruz de Tenerife, Spain2, 409 Prolonged Maintenance Interval Of Allergen Subcutaneous Im- DIATER Laboratories, Madrid, Spain3, Universitary Hospital of munotherapy during COVID19 pandemic Canary Islands, Santa Cruz de Tenerife. Spain4 Jaspreet Dhami, MD1, Vivian Wang, MD1, Mohamed Eloustaz, 419 Evaluation of House Dust Mite Dose Response in the Environ- MD2, Joseph Yusin, MD FAAAAI1, VA Greater Los Angeles mental Exposure Unit Healthcare System1, University of South California2 Lubnaa Hossenbaccus, BScH1, Jenny Thiele, MSc1, Lisa Steacy, 410 No Severe Anaphylaxis in Clinical Trials of House Dust Mite BSc, CCRP2, Terry Walker2, Crystal Malone2, Anne Ellis, MD Sublingual Immunotherapy Tablet Using a Standardized Iden- FRCPC FAAAAI1, Queen’s University1, Kingston Health Sciences tification Algorithm Centre2 Veronica Hulstroem1, Ruta Gronskyte Juhl, PhD1, Hendrik Nolte, MD PhD2, ALK, Hørsholm, Denmark1, ALK, Bedminster, NJ, USA2 Rhinosinusitis and Nasal Polyposis 411 Impact of Age and Region on Immune Responses to Allergy Im- 420 A Single-Center, Randomized, 3-Way, Crossover Study to Eval- munotherapy 1 uate the Effect of an Exhalation Delivery System on Nasal Ni- Josephine Nolte Peterlin , Vibeke Backer2, Thomas Stranzl3,Ve- 3 3 tric Oxide Concentrations in Patients with Chronic Sinusitis ronica Hulstroem , Peter Sejer Andersen , Hendrik Nolte, MD 1 2 4 Miguel Lanz, MD FAAAAI , Per Djupesland , John McGinnis, PhD , Center of Physical Activity Research (CFAS), Rigshospitalet, 3 3 3 1 MPH , Eric Zaccone, PhD , John Messina, PharmD , AAADRS University of Copenhagen, Copenhagen, D , Center of Physical Ac- Clinical Research Center1, OptiNose AS2, OptiNose US, Inc.3 tivity Research (CFAS), Rigshospitalet, University of Copenhagen, 421 The Study of a Novel Triple Spray Combination of Corticosteroid, Copenhagen, Denmark2, ALK, Hørsholm, Denmark3, ALK, Bed- Antihistamine and Decongestant Delivered in a Single Spray minster, NJ, USA4 Reimus Valencia, DO1, Phuong Daniels, DPT, OMS-II2, 412 Don’t Rush to Judgement: Systemic Reactions During Rapid Katheryn Birch, DO3, Tina Abraham, DO4, John Murray, MD PhD5, Desensitization to Multiple Aeroallergens 6 1 1 1 Robert Hostoffer, DO , University Hospitals, Cleveland Medical Cen- Alegra Grieb , Alexandra Chastant , Evan Atkinson, MD MS , 1 2 1 ter, Cleveland, Ohio , Lake Erie College of Osteopathic Medicine , Tulane University 3 413 Review of Systemic Reactions to Subcutaneous Immunotherapy University Hospitals, Cleveland Medical Center, Cleveland Ohio ,Pul- monary Allergy Critical Care & Sleep Medicine Associates, Rochester Based on Injection Schedule in a Single Allergy Practice 4 1 1 1 Hills, Michigan , McLaren Macomb Hospital, Mount Clemens, Mich- Walaa Hamadi, MD , Nerissa D’Silva, MD , Aurora Moberly , 5 6 Ashley Snyder, MPH1, Zach Ney1, Jeanna Ryan, PA-C1, Hannah igan , Allergy/Immunology Associates 422 Eosinophil-derived neurotoxin as a biomarker in children with Duffey, MD1, University of Utah1 414 Dosing Aeroallergen Immunotherapy from Freshly Prepared allergic rhinitis Kyunhoon Kim1, Woori Bae1, Hye Jin Lee1, Eun Ae Yang1, Hwan Maintenance Vials: To Adjust or Not? 1 1 1 1 2 Soo Kim, MD , Yoon Hong Chun , Jong-seo Yoon, MD PhD , Katherine Oberhelman, MD , Aimee Sutherland, MD , Evan At- 1 1 2 1 2 Hyun Hee Kim, MD , Jin Tack Kim , College of Medicine, The kinson, MD MS , St. Louis University , Tulane University 1 415 Autoserum Therapy as a Method of Non-specific Immunopro- Catholic University of Korea, Seoul, Korea phylaxis of Pollen Allergy 423 A Responder Analysis To Demonstrate Dupilumab Treatment 1 1 1 Effect Across Objective and Patient-Reported Subjective End- Iryna Shchurok , Dzmitry Novicov , Iryna Semenova , Aksana 1 2 points For Patients with Severe Chronic Rhinosinusitis with Na- Ishchenka , Lawrence Dubuske, MD FAAAAI , Vitebsk State Med- 1 sal Polyps (CRSwNP) ical University, Vitebsk, Belarus , George Washington University Claus Bachert, MD PhD1, Anju Peters, MD MSCI FAAAAI2,En- School of Medicine, Washington, DC, USA; Immunology Research 3 4 5 6 2 rico Heffler , Joseph Han, MD FAAAAI ,HeidiOlze,OliverPfaar, Institute of New England, Gardner, MA, USA 7 8 9 10 416 Efficacy of epinephrine rinse in allergen immunotherapy with Chien-Chia Chuang , Raj Rout , Richa Attre ,LediaGoga , Juby Jacob-Nara7, Paul Rowe, MD11, Yamo Deniz9, Zhen Chen, PhD9, aeroallergen and venom 9 9 1 2 Siddhesh Kamat , Shahid Siddiqui , Ghent University, Ghent, Bel- Phuong Daniels, DPT, OMS-II , Reimus Valencia, DO , Robert 1 Hostoffer, DO3, Lake Erie College of Osteopathic Medicine1, Uni- gium , Allergy-Immunology Division and the Sinus and Allergy 2 Center, Feinberg School of Medicine, Northwestern University, Chi- versity Hospitals, Cleveland Medical Center , Allergy/Immunology 2 Associates3 cago, IL, USA , Personalized Medicine, Asthma & Allergy - Hu- manitas Clinical and Research Center IRCCS, Rozzano, Milan, Italy3, Eastern Virginia Medical School, Norfolk, VA, USA4, Charite-Universit€atsmedizin, Berlin, Germany5, University Hospital Allergy Diagnostics Marburg, Philipps-Universit€at Marburg, Marburg, Germany6,Sanofi, 417 Evaluating sensitization patterns on ImmunoCAP-detected pol- Cambridge, MA, USA7, Sanofi Genzyme, Reading, UK8, Regeneron ysensitized patients with microarray-based multiplex assay Pharmaceuticals, Inc., Tarrytown, NY, USA9,Sanofi,Chilly-Mazarin, (ISAC) France10, Sanofi, Bridgewater, NJ, USA11 Sujoy Khan1, Harpal Singh, MBBS2, Ekansh Sharma3, Esben El- 424 Prevalence of cat induced allergic rhinitis in children with ler, PhD MSc4, Anirban Maitra5, Hull University Teaching Hospi- chronic and frequent rhinitis tals NHS Trust1, AstraZeneca Pharma India Ltd., New Delhi, Nichaporn Chalermpalanupap, MD1, Watcharoot Kanchongkit- India2, Thermo Fisher Scientific Immunodiagnostics Division, Up- tiphon, MD PhD2, Wiparat Manuyakorn, MD, PhD3, Woralak Su- psala, Sweden3, ThermoFisher Scientific, Uppsala, Sweden4, Man- tiratanachai, MD1, Suwat Benjaponpitak, CME4,Cherapat chester University Hospitals NHS Foundation Trust, UK5 Sasisakulporn1, Potjanee Kiewngam1, Wanlapa Jotikasthira1,Ma- 418 ALLERGY TO DERMATOPHAGOIDES PTERONYSSINUS. hidol University1, Washington University School of Medicine2, MOLECULAR RECOGNITION PATTERN ATTRIBUTED Ramathibodi Hospital3, Faculty of Medicine Ramathibodi TO DIFFERENT PATHOLOGIES Hospital4 AB200 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2021

425 Health-Related Quality of Life Impairment Among Patients Antwerp1, University Antwerp2, University of Antwerp - Belgium3, With Severe Chronic Rhinosinusitis With Nasal Polyps in the Antwerp University Hospital4 SINUS-24 Trial 435 Baseline serum tryptase levels in a pediatric population Jorge Maspero, MD FAAAAI1, Carl Philpott2, Peter Hellings, Alba Juarez1, Alicia Dominguez1, Joaquın Navarro1, Maria Luisa MD3, Claire Hopkins4, Martin Wagenmann, MD FAAAAI5, Shahid Baeza1, Alberto Alvarez-Perea1, Gregorio Maranon~ University Siddiqui6, Juby Jacob-Nara7, Jerome Msihid8, Chien-Chia Chuang7, General Hospital, Madrid, Spain1 Siddhesh Kamat6, Asif Khan8, Fundacion CIDEA, Buenos Aires, 436 Ephedra Herb, Mao, Inhibits Antigen-Induced Mast Cell De- Argentina1, Norwich Medical School, University of East Anglia, granulation by the Induction of the Affinity Receptor for IgE Norwich, UK2, University Hospitals Leuven, Leuven, Belgium3, Internalization ENT Department, Guy’s and St Thomas’ Hospitals, King’s College Yuka Nagata1, Hirokazu Ando1, Yohei Sasaki1, Ryo Suzuki1, Ka- London, UK4, Department of Otorhinolaryngology, Dusseldorf€ nazawa University, Kanazawa, Japan1 University Hospital (UKD), Dusseldorf,€ Germany5, Regeneron 437 Mast cells cultured from human peripheral blood and bone Pharmaceuticals, Inc., Tarrytown, NY, USA6, Sanofi, Cambridge, marrow: a phenotypic and functional comparison. MA, USA7, Sanofi, Chilly-Mazarin, France8 Jessy Elst, MD1, Didier Ebo, MD PhD FAAAAI2, Margaretha Faber, 426 Dupilumab as an adjunct to surgery in patients with aspirin-ex- MD PhD1, Athina Van Gasse1, Ine Decuyper, MD PhD1, Chris Bridts, acerbated respiratory disease: a case series MLT1, Leander De Puysseleyr1, Marie-Line Van Der Poorten, MD1, Pooja Patel1, Jillian Bensko, PA-C2, Tanya Laidlaw, MD Christel Mertens1, Margo Hagendorens, MD PhD3, Anke Verlinden4, FAAAAI3, Kathleen Buchheit, MD4, Beth Israel Deaconess Medi- Vito Sabato, MD1, University of Antwerp1, University Antwerp2,Uni- cal Center1, Brigham and Women2, Harvard Medical School3, Brig- versity of Antwerp - Belgium3, Antwerp University Hospital4 ham and Women’s Hospital4 438 A Phase 1, Single-Center, Randomized, Double-Blind, Placebo- 427 Decrease in Antibiotic Use and Radiographic Sinus Severity af- Controlled, Single Ascending Dose Study to Investigate the ter Functional Endoscopic Sinus Surgery in Patients with Safety, Tolerability, and Pharmacokinetics of Intravenous and Chronic Rhinosinusitis and Antibody Immunodeficiencies. Subcutaneous Garadacimab (CSL312) in Healthy Subjects Matthew Perez, MD1, Northwestern University1 Andrew McKenzie1, Anthony Roberts1, Sourabh Malandkar1, 428 Risk Factors Associated With COVID-19 Related Anosmia And Henrike Feuersenger2, Con Panousis3, Dipti Pawaskar4, CSL Lim- Ageusia ited, Parkville, Victoria, Australia1, CSL Behring GmbH, Marburg, Esha Sehanobish, PhD1,MaliBarbi1, Valerie Fong1,MerylKravitz1, Germany2, CSL Limited, Parkville, Victoria, Australia3, CSL Behr- Cynthia Matsumura1, Denise Tejera1, Mohammad Asad, PhD1, Denisa ing, King of Prussia, PA, USA4 Ferastraoaru, MD1, Meaghan O’Neill1, Merhunisa Karagic1, Nadeem 439 Cognitive Dysfunction and Co-morbid Psychiatric Disturbances Akhbar1, Danielle Bottalico1, Viraj Patel1, Golda Hudes, MD PhD1, in Chronic Allergic Conditions Mimi Kim1,RuthEisenberg1,AvindraNath2, Bryan Smith2, Thomas Daniel Rosenberg1, Sameer Mathur, MD PhD FAAAAI2, Ravi Ow1, Elina Jerschow, MD FAAAAI1, Albert Einstein college of Med- Viswanathan, MD2, University of Wisconsin Hospital and Clinics1, icine/Montefiore Medical Center1, National Institute for Neurologic University of Wisconsin School of Medicine and Public Health2 Disorders and Stroke, National Institutes of Health2 440 Low Immunoglobulin Levels In Patients With Mastocytosis 429 Alcohol Hypersensitivity In CRSwNP And Polyphenols And Associated Clinical Manifestations Will Eschenbacher1, Larry Borish, MD FAAAAI2, Monica Law- Kimberley Cousins1, Dean Metcalfe, MD FAAAAI2, Hirsh Ko- rence, MD FAAAAI3, Spencer Payne, MD1, University of Vir- marow, MD3, Melody Carter, MD FAAAAI4, Mount Sinai Hospi- ginia1, University of Virginia Health System2, University of tal1, Laboratory of Allergic Diseases/NIAID/NI2, NIAID/NIH3, Virginia Division of Asthm3 National Institutes of Health/NIAID/LAD4 430 Mitochondrial Oxidative Stress and Damage Is Associated with 441 Demographic Features of Children with Cutaneous Mastocyto- age-related Glandular Remodeling and Nasal Polyp Formation sis: One Institution’s Experience Ara Jo, PhD1, Jung Yeon Han1, Mark Tabor, MD1, Richard Arjola Cosper1, Denisa Ferastraoaru, MD2, Albert Einstein Col- Lockey, MD FAAAAI1, Seong Cho, MD FAAAAI1, University of lege of Medicine/Montefiore Medical Center1, Albert Einstein Col- South Florida1 lege of Medicine/Mont2 442 Fibroblasts Regulate Mast Cell Activation in Nasal Polyps Tahereh Derakhshan1, Chunli Feng, MD1, Kathleen Buchheit, MD1, Nora Barrett, MD1, Tanya Laidlaw, MD FAAAAI1, Joshua Mast Cells Boyce, MD FAAAAI1, Daniel Dwyer, PhD1, Jeff and Penny Vinik 431 A novel case of beta-tryptase/TPSB2 allele duplication Center for Allergic Disease Research, Division of Allergy and Clin- Madeleine Chollet1, Anna Kovalszki, MD1, Cem Akin, MD PhD ical Immunology, Brigham and Women’s Hospital. Department of 1 FAAAAI1, University of Michigan1 Medicine, Harvard Medical School, Boston, MA, USA 432 The Prevalence of Hereditary Alpha-Tryptasemia in Patients 443 Clinical significance of mast cell counts in patients presenting Diagnosed With POTS via Tilt Table Testing with mast cell disorders 1 1 Jenny Huang, MD1, Jose Criado Del Valle2, Andrew White, MD Simin Zhang , Umesh Singh, MD PhD , Nives Zimmermann, MD 2 3 FAAAAI2, Scripps Clinic/Scripps Green Hospital1, Scripps FAAAAI , Jonathan Bernstein, MD FAAAAI , University of Cin- 1 2 3 Clinic2 cinnati , Cincinnati Children , Bernstein Allergy Group, Inc 433 Hereditary Alpha-Tryptasemia: A Case Series with Various Clinical Presentations Navid Ziaie1, Shyam Joshi, MD1, Oregon Health and Science University1 Hypereosinophilia 434 Aberrant mature active mast cells in wasp venom anaphylaxis 444 Impact of Baseline Blood Eosinophil Count on Flare Reduction associated with clonal mast cell disorders in Mepolizumab-Treated Patients With Hypereosinophilic Syn- Leander De Puysseleyr1, Jessy Elst, MD1, Didier Ebo, MD PhD drome FAAAAI2, Margaretha Faber, MD PhD1, Athina Van Gasse1, Ine Marc Rothenberg, MD PhD FAAAAI1, Florence Roufosse2, Sta- Decuyper, MD PhD1, Christel Mertens1, Michel Van Houdt, nislas Faguer3, Gerald Gleich, MD FAAAAI4, Jean-Emmanuel MLT1, Margo Hagendorens, MD PhD3, Katrien Vermeulen, PhD4, Kahn5, Jonathan Steinfeld, MD6, Namhee Kwon, MD PhD7, Jane Zwi Berneman, MD, PhD4, Vito Sabato, MD1, University of Bentley, MSc8, Steve Yancey9, Cincinnati Children’s Hospital J ALLERGY CLIN IMMUNOL Abstracts AB201 VOLUME 147, NUMBER 2

Medical Center; University of Cincinnati, Cincinnati, OH, USA1, Allergic Mechanisms Hopital^ Erasme, Universite Libre de Bruxelles, Brussels, Belgium2, Centre de Reference des Maladies Renales Rares, Hopital^ Rangueil, 450 Variability in Total IgE Levels in Patients Receiving Monoclo- 3 nal Biologics for Allergic Conditions CHU de Toulouse, Toulouse, France , School of Medicine, Univer- 1 1 2 4 ^ Moshe Beiser , Deborah Schwartz , Denisa Ferastraoaru, MD , Al- sity of Utah, Salt Lake City, UT, USA ,Hopital Ambroise Pare, 1 bert Einstein College of Medicine , Albert Einstein College of Universite Versailles-Saint Quentin-en-Yvelines, Boulogne-Billan- 2 court, France5, GSK, Collegeville, PA, USA6, GSK, Brentford, Medicine/Mont 7 8 451 Purification and initial studies on vitellogenin, an allergen in London, UK , GSK, Stockley Park, Uxbridge, Middlesex, UK , 9 German cockroach GSK, Research Triangle Park, NC, USA 1 1 2 445 An International, Retrospective Study of Off-Label Biologic Use Joshua Somers , Benjamin Rosen , Coby Schal, PhD , Taruna Khurana, PhD3, Samuel Mindaye, PhD4, Jay Slater, MD5,US in the Treatment of Hypereosinophilic Syndromes (HES) 1 2 1 2 3 Food and Drug Administration , North Carolina State University , Michael Chen ,PraveenAkuthota,MD, Timothy Lax ,Sameer 3 4 5 Mathur, MD PhD FAAAAI4, Princess Ogbogu, MD FAAAAI5,Tha- CBER/FDA ,FDA, FDA/CBER/OVRR/DBPAP nai Pongdee, MD FAAAAI6, Marc Rothenberg, MD PhD FAAAAI7, 452 Proteomic evaluation of Alternaria alternata spores, hyphae, 8 9 10 11 and commercial allergen extracts Florence Roufosse , Dagmar Simon ,MiguelStein , Sa Wang , 1 1 1 12 13 Michael Strader ,RamizAhmad, Aishwarya Saha , Brett Green, Michael Wechsler, MD , Amy Klion, MD , Bruce Bochner, MD 2 3 1 PhD FAAAAI , Angela Lemons, MS , Donald Beezhold, PhD FAAAAI , Northwestern University Feinberg School of Medicine, 3 4 1 2 FAAAAI , Robert Hamilton, PhD DABMLI FAAAAI ,Samuel Chicago, IL , University of California San Diego, La Jolla, CA , 5 6 3 Mindaye, PhD , Jay Slater, MD , US Food and Drug Administra- Beth Israel Deaconess Medical Center, Boston, MA , University of 1 2 3 4 tion , Centers for Disease Control and Preventi ,NIOSH, Johns Wisconsin, Madison, WI , The Ohio State University Wexner Med- 4 5 5 6 Hopkins University School of Medic ,FDA, FDA/CBER/ ical Center, Columbus, OH , Mayo Clinic, Rochester, MN , Cincin- 6 nati Children’s Hospital Medical Center, Cincinnati, OH7,Hopital^ OVRR/DBPAP 8 453 Genetic Deficiency of ß-Arrestin-1 Has No Effect on Airway Hy- Erasme, Universite libre de Bruxelles, Brussels, Belgium ,Inselspi- 9 perresponsiveness or Lung Histopathology in a Mouse Model of tal, Bern University Hospital, University of Bern, Bern, Switzerland , 10 Allergic Occupational Asthma Edith Wolfson Medical Center, Tel Aviv University, Holon, Israel , 1 1 1 11 Richard Johnston , Albert Pilkington, IV , Lori Battelli , Michael MD Anderson Cancer Center, Houston, TX , National Jewish 1 1 12 Kashon , Jeffrey Reynolds , National Institute for Occupational Health, Denver, CO , National Institutes of Health, Bethesda 1 MD13 Safety and Health 446 Impact of mepolizumab on symptom severity in patients with 454 Lipopolysaccharide (LPS) protects from severe respiratory par- amyxoviral viral infection through an innate immune response hypereosinophilic syndrome 1 2 2 1 2 Jenny Resiliac ,MichelleRohlfing, Jennifer Santoro , Syed-Rehan Florence Roufosse , Joseph Butterfield, MD FAAAAI , Robyn von 2 1 3 4 5 Hussain, PhD , Mitchell Grayson, MD , Abigail Wexner Research Maltzahn, MSc , Linda Nelsen, MHS , Jane Bentley, MSc , Nam- 1 6 4 ^ Institute at Nationwide Children’s and The Ohio State University , hee Kwon, MD PhD , Jonathan Steinfeld, MD ,Hopital Erasme, 2 Universite Libre de Bruxelles, Brussels, Belgium1, Mayo Clinic, Abigail Wexner Research Institute at Nationwide Children’s 455 Food antigen sensitization in genetically-susceptible mice is 200 1st St SW, Rochester, MN 55905, USA2, GSK, London, influenced by fecal IgA, antigen absorption, and gut micro- UK3, GSK, Collegeville, PA, USA4, GSK, Stockley Park, Uxbridge, 5 6 biome composition Middlesex, UK , GSK, Brentford, London, UK 1 2 447 Effect of Dupilumab Treatment on Blood Eosinophil Levels in Johanna Smeekens, PhD , Brandi Johnson-Weaver , Andrew Hin- ton3, M. Andrea Azcarate-Peril3, Timothy Moran, MD PhD4, Rob- Patients With Asthma, Chronic Rhinosinusitis With Nasal 5 3 Polyps (CRSwNP), Eosinophilic Esophagitis (EoE), or Atopic ert Immormino, PhD , Janelle Kesselring , Erin Steinbach, MD PhD6, Kelly Orgel3, Herman Staats7, A. Wesley Burks, MD Dermatitis (AD) 3 3 3 3 1 2 3 FAAAAI , Peter Mucha , Martin Ferris, PhD , Mike Kulis , Uni- Michael Wechsler, MD , Amy Klion, MD , Pierluigi Paggiaro , 1 2 4 5 versity of North Carolina at Chapel Hill , Duke University , Uni- Parameswaran Nair, MD PhD , Delphine Staumont-Salle , Amr 3 6 7 7 6 versity of North Carolina , University of North Carolina School Radwan , Robert Johnson , Upender Kapoor , Faisal A. Khokhar , 4 5 7 6 7 of Medicine , UNC Chapel Hill , University of North Carolina at Nadia Daizadeh , Zhen Chen, PhD , Elizabeth Laws , Juby Jacob- 6 7 Nara7, Leda Mannent, MD7, Marcella Ruddy, MD6, Paul Rowe, Chapel H , Duke University Medical Center 456 Human IgE Monoclonal Antibodies to Inhaled and Food Aller- MD7, Yamo Deniz6, National Jewish Health1, Laboratory of Para- gens: Unique Probes for Clinical Investigation. sitic Diseases, National Institute of Allergy and Infectious Diseases, 1 1 2 3 Martin Chapman, PhD FAAAAI , Crystal Richardson, PhD ,Bryan National Institutes of Health , University of Pisa , Firestone Insti- Smith2, Kristina Reid Black2, Jill Glesner1, Scott Smith, MD PhD3, tute of Respiratory Health, McMaster University & St. Joseph’s 2 1 4 ^ Anna Pomes, PhD FAAAAI , Indoor Biotechnologies, Inc. , INDOOR Healthcare Hospital , Service de Dermatologie, Hopital Claude 2 3 5 6 7 Biotechnologies , Vanderbilt University Medical Center Huriez – CHRU , Regeneron Pharmaceuticals, Inc. , Sanofi 457 Inflammatory response of ethanol and its metabolites in human 448 Description of Hypereosinophilic syndrome (HES) and subtypes primary bronchial epithelial cells pre-stimulated with LPS in the literature 1 2 1 2 Dustin Fowler, DO , Lata Kaphalia, MS, MED, PhD , William Cal- Praveen Akuthota, MD , Gema Requena, PhD , Judith van den 2 1 3 4 houn, MD FAAAAI ,UTMB, University of Texas Medical Bosch, PhD , Jonathan Steinfeld, MD , Namhee Kwon, MD 2 2 5 4 Branch PhD , Anna Kovalszki, MD , Melissa van Dyke, PhD , University 458 Staphylococcus aureus Carriage and Differential Cell Counts in of California, San Diego, La Jolla, CA, USA1, GSK, Brentford, Nasal Lavages of Ragweed-Induced Allergic Rhinitis Using Na- London, UK2, Pallas Health Research and Consultancy, Rotterdam, sal Allergen Challenge the Netherlands3, GSK, Collegeville, PA, USA4, University of Sophia Linton1, Rashi Ramchandani1, Alyssa Burrows2,Jenny Michigan, Ann Arbor, MI, USA5 Thiele, MSc1, Lisa Steacy, BSc, CCRP3, Prameet Sheth, PhD1, 449 Hypereosinophilic Syndrome (HES) Presenting as Coagulopathy 1 1 1 1 2 Anne Ellis, MD FRCPC FAAAAI , Queen’s University , Kingston Al- Kestutis Aukstuolis, DO , Katherine Altman , Andrew Ayars , 2 1 2 1 lergy Research Unit , Kingston Health Sciences Centre - KGH Anna Lang , Clinton Dunn, MD , University of Washington , Uni- 3 2 Site versity of Washington School of Medic AB202 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2021

459 Cytokines of Ejaculate from Men with Chronic Prostatitis/ Tamar Kinaciyan, MD5, Marycliff Clinical Research1, Mount Sinai chronic Pelvic Pain Syndromes Treated by Extracorporeal School of Medicine2, BioCryst Pharmaceuticals3, BioCryst Phar- Shockwave Therapy maceuticals, Inc.4, Medical University of Vienna, Dept. Of D5 I Gorpynchenko1, K Nurimanov1, T Poroshina1, V Savchenko1,G 466 Safety and Outcomes for Penicillin Skin Testing in Pregnancy Drannik1, Lawrence Dubuske, MD FAAAAI2, Institute of Urology Vima Patel1, Olajumoke Fadugba, MD1, Steven Ralston, MD, of NAMS of Ukraine, Kyiv, Ukraine1, George Washington Univer- MPH1, Kathryn Delaney, MD1, Scott Feldman, MD PhD1, Univer- sity School of Medicine, Washington, DC, USA; Immunology Re- sity of Pennsylvania1 search Institute of New England, Gardner, MA, USA2 467 Efficacy and Safety of Abrocitinib in Adolescent Patients With 460 Production of Recombinant Cannabis Sativa Allergen, Can s 3, Moderate-to-Severe Atopic Dermatitis (AD): Results From the and Development of a Two-site Immunoassay Phase 3 JADE TEEN study Bryan Smith1, Kristina Reid Black1, Cathy Thorpe1, Sayeh Agah1, Lawrence Eichenfield1, Carsten Flohr2, Robert Sidbury3, Zsuz- Stephanie Filep1, Sabina Wuenschmann, PhD1, Martin Chapman, sanna Szalai4, Ryszard Galus5, Zhirong Yao6, Hidetoshi Takaha- PhD FAAAAI1, Indoor Biotechnologies1 shi7,Sebastien Barbarot8, Claire Feeney9, Fan Zhang10, Marco 461 Boxing Changes Chemokine Production by PBMC DiBonaventura10, Ricardo Rojo10, Hernan Valdez10, Gary Chan10, Roman Khanferyan1,NRiger2,MKorosteleva3, Lawrence Dubuske, UC San Diego1, St John’s Institute of Dermatology, Guy’s and St MD FAAAAI4, Peoples’ Friendship University of Russia, Moscow, Thomas’ NHS Foundation Trust, King’s College London2, Seattle Russia1, Federal Scientific-research Center on Nutrition Children’s Hospital3, Heim Pal Children’s Hospital4, Medical Uni- versity of Warsaw5, Xinhua Hospital, Shanghai Jiaotong University School of Medicine6, Takagi Dermatological Clinic7, CHU Hotel-^ 2801 The Best of Anaphylaxis, Dermatology and Dieu8, Pfizer Ltd.9, Pfizer Inc.10 468 Application of a Physiologically Based Modeling to Increase the Drug Allergy Knowledge on Epinephrine Absorption from A Novel Nasal Spray (ARS-1) In Healthy Adults Jeff Barrett1, Critical Path Institute1 469 NTLA-2002: CRISPR/Cas9-mediated gene knockout of KLKB1 Saturday, February 27, 2021, 05:10 pm - 06:25 to treat hereditary angioedema pm Jessica Seitzer1, Intellia Therapeutics1 462 Efficacy of Lanadelumab in Hereditary Angioedema Patients 470 Safety and Outcomes of 2-step Non-steroidal Anti-inflammatory With and Without Prior Use of Long-Term Prophylaxis: Final Drug Provocation Tests in the Outpatient Setting 1 1 1 Results From the HELP Open-Label Extension Study Lily Li, MD , Kathleen Buchheit, MD , Jillian Bensko, PA-C , Re- 2 1 Kim Paes, Clinical Scientist1, Jonathan Bernstein, MD FAAAAI2, becca Saff, MD PhD FAAAAI , Tanya Laidlaw, MD FAAAAI , 1 Hilary Longhurst, PhD MBBS MRCP FRCP3, Emel Aygoren-Pur- Brigham and Women’s Hospital , Massachusetts General 2 sun, MD4, Hong Ren, MS5, Timothy Craig, DO FAAAAI6, Takeda Hospital Pharmaceutical Company Limited, Lexington, MA, USA1 Department of Internal Medicine, Division of Immunology, University of Cincinnati College of Medicine, Bernstein Allergy Group and Bernstein Clinical Research Center, Cincinnati, OH, 2802 Asthma Pathophysiology, Epidemiology, 2 USA Addenbrooke’s Hospital, Cambridge University Hospitals and Treatment NHS Foundation Trust, Cambridge, and University College London Hospitals, London, UK3 Department for Children and Adolescents, Angioedema Centre, University Hospital Frankfurt, Goethe University, Frankfurt, Germany4 Cytel Inc., Cambridge, MA, Saturday, February 27, 2021, 05:10 pm - 06:25 USA5 Department of Medicine, Pediatrics and Graduate Studies, Penn State University Hershey Medical Center, Hershey, pm PA, USA6 471 Association of step count with PROMIS health-related quality 463 Pregnancy and infant outcomes among pregnant women with of life measures in children and adolescents with persistent Chronic Spontaneous Urticaria (CSU) treated with omalizu- asthma mab: a descriptive analysis from the EXPECT pregnancy regis- Allison Burbank, MD1, Michelle Hernandez, MD FAAAAI1, try Nicole Lucas2, Courtney Mann2,LiLin2, Wanda Phipatanakul, Jennifer Namazy, MD FAAAAI1, Angela Scheuerle, MD2,Vic MD MS FAAAAI3, Jessica Brown4,MishaSims4, Sally Ivins, Spain, PhD DVM3, Pranathi Janampally3, Ayesha Ahmed, BA4, Antonia Bennett5, Amparito Cunningham, MD MPH6,Mi- PharmD3, Sachin Gupta, MD3, Cecile Holweg3, Nayla Mumneh4, chelle Maciag, MD3, Nicole Akar-Ghibril, MD3, Bryce Reeve7, Cristine Radojicic, MD5, Scripps Clinic1, University of Texas University of North Carolina, Chapel Hill1,DepartmentofPopu- Southwestern Medical Center2, Genentech, Inc.3, Novartis Pharma- lation Health Sciences, Duke University School of Medicine, Dur- ceuticals Corp4, Duke Asthma, Allergy, and Aiway Center5 ham, NC2, Boston Children’s Hospital3, University of North 464 Skin Macrophages Drive Immune Dysregulation in Atopic Der- Carolina at Chapel Hill4, Department of Health Policy and Man- matitis agement, University of North Carolina at Chapel Hill5, Harvard Sabina Islam1, Ellinor Tai, BS1, Julianna Tengku, B A2, Akiba University6, Department of Pediatrics, Duke University School Sato, MS1, Massachusetts General Hospital1, Massachuestts Gen- of Medicine, Durham, NC7 eral Hospital2 472 Childhood Asthma and Mitochondrial Biomarkers for Expo- 465 Berotralstat Reduces Use of On-demand Medication in Hered- sure-Related Outcomes (CAMERO) study: Time-related itary Angioedema (HAE) Patients Previously Treated with Pro- Changes in Mitochondrial DNA Copy Number phylactic Therapies Jessica Oh, MD1, Janelle Rivera1, Jacqueline Jezioro, MS1, Lydia Richard Gower, MD FAAAAI1, Paula Busse, MD FAAAAI2, Jes- Lichtiger1, Kyung Jung2, Matthew Perzanowski, PhD2, Elizabeth sica Best, DHSc, PA3, Sharon Murray, PhD3, Heather Iocca, PhD4, Matsui, MD MHS FAAAAI3, Rachel Miller, MD FAAAAI1, Icahn J ALLERGY CLIN IMMUNOL Abstracts AB203 VOLUME 147, NUMBER 2

School of Medicine at Mount Sinai1, Columbia University2, Dell Behnam Keshavarz, PhD1, Joseph Wiencek, PhD2, Lindsay Bazy- Medical School at the University of3 dlo, PhD1, Matthew Straesser, MD3, Lisa Workman, BA1, Thomas 473 Gene-expression Patterns of Inflammation in Asthma Associ- Platts-Mills, MD PhD FAAAAI1, Jeffrey Wilson, MD PhD1, Uni- ated with Brain Activation versity of Virginia1, Vanderbilt University2, Central Pennsylvania Melissa Rosenkranz1, Kimberly Dill-McFarland, PhD2,Stephane Asthma and Allergy3 Esnault3, Nizar Jarjour, MD3, William Busse, MD FAAAAI3, 481 Enhanced BAFF expression is negatively correlated with a sup- Matthew Altman, MD2, University of Wisconsin-Madison1,Uni- pressed isotype-switched memory B cell pool in CVID patients versity of Washington2, University of Wisconsin School of with complications Medicine3 Charlotte Cunningham-Rundles, MD PhD FAAAAI1, Lin 474 Asthma Exacerbations and Intimate Partner Violence Radigan, MD2, Haoli Jin, MD PhD3, Mt. Sinai Medical Center1, Eileen Wang, MD1, Bryan Simmons1, Kristen Holm1, Frederick Icahn School of Medicine at Mount Sinai2, Mount Sinai Health Wamboldt1, National Jewish Health1 Network3 475 Five-month Outcomes for Asthmatics with COVID-19 and As- 482 Selective IgA deficiency alters systemic immune response to sociations with Atopy and Inhaled Corticosteroids Use commensal gut microbiome Katharine Foster1, Donyea Moore, BSc2, Emilio Jauregui, MD3, Peyton Conrey1, Lidiya Denu2, Kaitlin O3, Jean-Bernard Lubin, Aame Andy-Nweye1, Mahboobeh Mahdavinia, MD PhD PhD4, Tereza Duranova5, Laura Vella, MD/PhD2, E. John Wherry, FAAAAI1, Rush University Medical Center1, Rush University Med- PhD3, Jonathan Spergel, MD, PhD6, Michael Silverman, MD/PhD2, ical Center, Chicago, IL2, Los Angeles County+University of Children1, Children’s Hospital of Philadelphia2, University of Penn- Southern California Medical Center3 sylvania3, Childrens Hospital of Philadelphia4, CHOP5, Children 476 Comorbid Asthma Within a Prospective Household Study of Hospital of Philadelphia6 Respiratory Viral Infections 483 Alterations in STAT Signaling Dysregulate CD8 T Cell Activa- Alastair Murray1, Janet Englund, MD1, Naomi Wilcox, MPH2, tion Jessica Heimonen, MPH2, Anne Emanuels, MPH2, Helen Chu, Jose Campos1,PeytonConrey2, Samir Sayed3, Tiphanie Vogel, MD/ MD, MPH2, University of Washington, Seattle Children’s Hospi- PhD4, Jennifer Leiding, MD FAAAAI5,LisaForbesSatter,MD tal1, University of Washington2 FAAAAI6,StevenHolland,MD7, Alexandra Freeman, MD7,Univer- 477 Nociceptor Neurons Control Pollution-exacerbated Asthma sity of Pennsylvania1,Children2, The Children3, Texas Children’s JO-CHIAO WANG1, Theo Crosson1, Tuany Eichwald2, Katiane Hospital4, University of South Florida5, Texas Children6,NIH7 Roversi1, Maryam Ahmadi1, Mohammad Balood1, Sebastien Tal- 484 SARS-CoV-2 full length spike protein for COVID-19 vaccine bot, PhD3, Universite de Montreal1, Universidade Federal de Santa development and diagnostic testing Catarina2, University of Montreal3 Crystal Richardson, PhD1, Mayuresh Abhyankar2, Jillian Braca- 478 QCT-based Measures Of Airway Narrowing And Shape glia1, Sayeh Agah1, Zachary Schuhmacher, BS1, Bryan Smith1, Sa- Changes Associated With Endobronchial Biopsy Tissue Mea- bina Wuenschmann, PhD1, William Petri, Jr., MD, PhD2, Martin sures of Airway Remodeling And Clinical Outcomes In Asthma Chapman, PhD FAAAAI1, Anna Pomes, PhD FAAAAI1, Indoor Bi- Jiwoong Choi1, Jonathan Boomer2, In Kyu Lee3, Fred Shi4, Ste- otechnologies, Inc.1, University of Virginia2 phanie Christenson5, Jenna Nguyen6, Leonard Bacharier, MD 485 Outcomes of SARS-CoV2 infection in STAT3 and PGM3 Defi- FAAAAI7, Prescott Woodruff, MD, MPH6, Michael Peters, MD6, ciency Sanghun Choi8, Ching-Long Lin9, Mario Castro, MD MPH2, Uni- Muhammad Khalid, MD1, Amanda Urban, CRNP2, Dirk Darnell, versity of Kansas School of Medicine, Kansas City, KS; University RN1, Alexandra Freeman, MD1, NIAID, National Institute of of Kansas, Lawrence, KS1, University of Kansas School of Medi- Health1, Clinical Research Directorate, Frederick National Labora- cine, Kansas City, KS; Washington University School of Medicine, tory for Cancer Research2 St. Louis, MO2, University of Kansas, Lawrence, KS; University of 486 Immunodeficiency during COVID-19 pandemic: analysis of a Kansas School of Medicine, Kansas City, KS3, University of Kan- 243 patients’ cohort followed at a Brazilian tertiary hospital. sas School of Medicine, Kansas City, KS4, University of California Laıs Cunha1, Priscila Franco, MD1, Bruna Gehlen, MD1,Ma- School of Medicine, San Francisco, CA5, University of California, riana Fernandes, MD1, Alex Prado, MD1, Grazielly Pereira2,Per- San Francisco, CA6, Washington University School of Medicine, eira GF1, Ana Karolina Marinho, DO1, Otavio Grecco1,Myrthes St. Louis, MO7, KyungPook National University, Daegu, Korea8, Barros, MD, PhD1, Jorge Kalil, MD, PhD1, Cristina Kokron, University of Iowa, Iowa City, IA9 MD, PhD1, University of S~ao Paulo1, Hospital das Clı´nicas, 479 Pediatric Emergency Visits for Asthma Drop Significantly with FMUSP, Sa˜oPaulo,Brazil2 COVID19 School Closure 487 Impact of the COVID-19 pandemic on physical and mental Elizabeth Secord1, Pavadee Poowuttikul, MD FAAAAI2, Milind Pan- health among individuals with primary immunodeficiency: re- sare2, Divya Seth2, Shweta Saini, MD3, Wayne State University1,Cen- sults of a nationwide survey tral Michigan University2, Children’s Hospital of Michigan3 Deepti Deshpande, MD1, Christopher Scalchunes, MPA2, Jordan Orange, MD PhD FAAAAI3, Joshua Milner, MD FAAAAI3, Co- lumbia University1, Immune Deficiency Foundation (IDF)2, Colum- bia University Irving Medical Center/ Presbysterian Hospital3 488 Relationship of Gut-Associated Lymphoid Tissue and the Gut 2803 The Best of Basic and Clinical Immunology Microbiome in Experimental Salmonella-induced Intestinal In- flammation Halyna Koval1, Aleksandr Kamyshnyi2, Yulia Bukina2, Iryna Bi- lous1, Lawrence Dubuske, MD FAAAAI3, Bukovinian State Medi- Saturday, February 27, 2021, 05:10 pm - 06:25 cal University, Chernivtsi, Ukraine1, Zaporozhye State Medical pm University, Zaporozhye, Ukraine2, George Washington University 480 Quantitative Measurement of IgG to SARS-CoV-2 Proteins Us- School of Medicine, Washington, DC, USA; Immunology Research 3 ing the Phadia ImmunoCAP 250 Institute of New England, Gardner, MA, USA AB204 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2021

2804 Cells and Molecules of Allergic 2805 Biologics in Allergic and Respiratory Disease Inflammation

Saturday, February 27, 2021, 05:10 pm - 06:25 pm Saturday, February 27, 2021, 05:10 pm - 06:25 461A Dupilumab Improves Signs And Symptoms Of Severe Atopic Dermatitis In Children Aged 6–11 Years With And Without Co- pm morbid Allergic Rhinitis 489 CARD14 is Required for FLG Homeostasis in Human Skin, and Lisa Beck, MD FAAAAI1, Andreas Wollenberg, MD FAAAAI2, the CARD14 Variant Rs11652075 Regulates the Expression of Amy Paller, MD3, Elaine Siegfried, MD4, Zhen Chen, PhD5, Alvina FLG in a Genotype-Dependent Fashion Abramova, PharmD, RPh5, Randy Prescilla, MD6, University of 1 2 2 Stanley DeVore , Mariana Stevens, PhD , Hua He, MS , Jocelyn Rochester Medical Center, Rochester, NY, USA1, Ludwig-Maximil- 2 2 2 Biagini Myers, PhD , John Kroner, MS , Lisa Martin, PhD , Gurjit lian University, Munich, Germany2, Northwestern University Fein- 2 Khurana Hershey, MD PhD FAAAAI , University of Cincinnati berg School of Medicine, Chicago, IL, USA3, Saint Louis 1 College of Medicine , Cincinnati Children’s Hospital and Medical University and Cardinal Glennon Children’s Hospital, St. Louis, 2 Center MO, USA4, Regeneron Pharmaceuticals, Inc., Tarrytown, NY, 490 Natural Human IgE Monoclonal Antibody Defines a Unique USA5, Sanofi Genzyme, Cambridge, MA, USA6 Epitope on Der p 2 498 Patient-Reported Outcomes (PROs) With Abrocitinib Treat- 1 1 2 Anna Pomes, PhD FAAAAI , Jill Glesner , Anyway Kapingidza , ment in Adolescent Patients With Moderate-to-Severe Atopic 1 1 Crystal Richardson, PhD , Lisa Vailes , Sabina Wuenschmann, Dermatitis (AD): Results From the Phase 3 JADE TEEN Study 1 1 3 PhD , Martin Chapman, PhD FAAAAI , Scott Smith, MD PhD , Amy McMichael1, Michael Cork2, Joyce Teng3, Ricardo Rojo4, 2 1 Maksymilian Chruszcz, PhD , Indoor Biotechnologies, Inc. , Uni- Hernan Valdez4, Fan Zhang4, Daniela Myers4, Gary Chan4, Marco 2 versity of South Carolina , Vanderbilt University Medical DiBonaventura4, Wake Forest School of Medicine1, Sheffield Der- 3 Center matology Research, University of Sheffield2, Stanford University3, 491 Effects of Androgen Receptor (AR) Signaling on Airway inflam- Pfizer Inc.4 mation in an Obesity-Associated Asthma Model 499 Tezepelumab Efficacy in Patients with Allergic and Non-Allergic 1 2 Nowrin Chowdhury , Jacqueline Cephus, MS , Vivek Gandhi, Asthma: A Post Hoc Analysis of the PATHWAY Phase 2b Study 2 3 2 PhD , Stokes Peebles, MD FAAAAI , Jeffrey Rathmell ,Dawn Jonathan Corren, MD1,GeneColice,MD2, Kinga Salapa, Msc3, 2 1 Newcomb, PhD , Vanderbilt University , Vanderbilt University Karin Bowen2, Jean-Pierre Llanos-Ackert, MD4, University of Cali- 2 3 Medical Center , Vanderbilt Univ School of Medicine fornia, Los Angeles (UCLA), CA, USA1, AstraZeneca, Gaithersburg, 492 Proteomic analysis of Food Protein Induced Enterocolitis Syn- MD, USA2, AstraZeneca, Warsaw, Poland3, Amgen, Thousand Oaks, drome (FPIES) reactions reveals Th17 immune signature CA, USA4 1 1 2 Cecilia Berin, PhD , Charuta Agashe , Mary Grace Baker, MD ,J. 500 The Effect of Benralizumab On Allergen-Induced Responses In 3 4 Andrew Bird, MD FAAAAI , Anna Nowak-Wegrzyn, MD, PhD , Subjects With Mild Allergic Asthma 1 Mount Sinai School of Medicine , Icahn School of Medicine at Gail Gauvreau1, Roma Sehmi, PhD1, J FitzGerald, MD2, Richard 2 3 Mount Sinai , UT Southwestern Medical Center , NYU Langone Leigh, MD PhD3, Donald Cockcroft, MD FAAAAI4, Beth Davis, 4 Health PhD4, Irvin Mayers, MD5, Louis-Philippe Boulet, MD FRCPC6, 493 CysLT1R antagonists block early P2Y6 receptor-dependent sig- Brittany Salter, MD, PhD1, Ruth Cusack, MD1, Imran Satia, MD, naling that prevents type 2 allergic sensitization PhD1, Kieran Killian, MD1, Patrick Mitchell, MB BCh3, Viktoria 1 2 1 Jun Nagai, PhD , Junrui Lin , Barbara Balestrieri, MD , Laura Werkstrom, MD, PhD7, Tomasz Durzynski, MD, PhD8, Kathryn 1 1 2 Fanning, MD , Timothy Kyin, MD , Haley Cirka , Patrick Brennan, Shoemaker, MS9, Rohit Katial, MD FAAAAI9, Maria Jison9, Paul 1 1 MD PhD , Joshua Boyce, MD FAAAAI , Harvard Medical School/ Newbold, PhD9, Paul O’Byrne, MD1, McMaster University1, Uni- 1 Brigham and Women’s Hospital , Brigham and Women’s versity of BC2, University of Calgary3, University of Saskatoon4, 2 Hospital University of Alberta5, Laval University6, AstraZeneca, Sweden7, 494 Basal Cell Adhesion Molecule Marks an Early Progenitor Epi- AstraZeneca, Poland8, AstraZeneca, USA9 thelial Cell in the Murine Trachea 501 Biologic Pathways Involved In Chronic Spontaneous Urticaria 1 2 Xin Wang , Nora Barrett, MD , Brigham and Women’s Hospital, And Response To Benralizumab Treatment 1 2 Harvard Medical School. , Brigham and Women Debayoti Ghosh, PhD1, Umesh Singh, MD PhD2, Jonathan 495 Dysfunctional Mucosal Immune Defense in CRS Increase Sus- Bernstein, MD FAAAAI3, University of Cincinnati College ceptibility to Staphylococcus Aureus of Medicine1, University of Cincinnati2, Bernstein Allergy Group, 1 2 3 Sun Mi Choi , Sandra Christiansen, MD , Adam DeConde , Taylor Inc3 4 5 Doherty, MD FAAAAI , Victor Nizet , University of California, 502 Ligelizumab is more effective in patients with chronic spontane- 1 2 3 San Diego , UCSD , University of California San Diego ,UC ous urticaria previously treated with omalizumab 4 5 San Diego , University CA San Diego School Medicine Karl Sitz, MD FAAAAI1, Gordon Sussman, MD FAAAAI2, 496 A Transcription Factor Blimp1 in CD4+ T cells Promotes Type Martin Metz3, Michihiro Hide, MD PhD4, Marcus Maurer, MD5, 2 Immune Responses in the Lungs While it Suppresses IgE An- Nathalie Barbier, Statitiscian6, Eva Hua6, Reinhold Janocha, PhD7, tibody Production in Mice Thomas Severin7, Little Rock Allergy and Asthma Clinic, P1, 1 1 Koji Matsumoto, MD , Takao Kobayashi, PhD , Koji Iijima, University of Toronto2, Charite Campus Mitte3,Hiroshima 2 1 1 2 PhD , Hirohito Kita, MD , Mayo Clinic Arizona , Mayo Clinic University4, Charite-Universitatsmedizin Berlin5, Novartis6, Novartis 497 Circulating fetal mast cell progenitors are phenotypically dis- Pharma AG7 tinct from adult progenitors 503 Clinical Outcomes of Biologic Therapy on Asthma in a Medi- 1 2 Hannah Martin , Joshua Boyce, MD FAAAAI , Daniel Dwyer, cally Underserved Urban Population 3 1 2 PhD , Brigham and Women’s Hospital , Brigham and Women , Sylwia Nowak1, Liseth Burbano1, James Moy1, Byung Yu, MD 3 Harvard Medical School FAAAAI1, Dipika Patel1, Cook County Health, Chicago, IL1 J ALLERGY CLIN IMMUNOL Abstracts AB205 VOLUME 147, NUMBER 2

504 A Single-Dose of REGN1908-1909 Reduced Bronchoconstric- MD, PhD1, Hospital Universitario de Canarias1, Hospital tion in Cat-Allergic Subjects with Mild Asthma for up to 3 Universitario de Canarias, Tene2 months following a controlled cat allergen challenge: A Phase 511 Intensive Infection Control at a Canadian Tertiary Allergy and 2, Randomized, Double-Blind, Placebo-Controlled Study Clinical Immunology Clinic during COVID-19 to Provide Cru- Frederic De Blay De Gaix, MD1, Alina Gherasim, MD1, Nathalie cial Services Domis1, Pretty Meier2, Furat Shawki2, Michelle DeVeaux2, Divya Jodi Valois, RPN1, Hoang Pham, MD2, Derek Lanoue, MD3,Tim Ramesh2, Lorah Perlee, PhD3, Gary Herman, MD2, David Wein- Olynych, MD PhD4, William Yang, MD FAAAAI4, Ottawa Allergy reich2, George Yancopoulos2, Meagan OBrien2, ALYATEC Envi- Research Corporation, Ottawa, ON, Canada1, McGill University ronmental Exposure Chamber1, Regeneron Pharmaceuticals, Inc.2, Health Centre, Montreal, QC, Canada2, University of Ottawa3, Uni- Regeneron Pharmaceuticals Inc.3 versity of Ottawa & Ottawa Allergy Research Corporation, Ottawa, 505 A Comparison of Lysine Acetylsalicylate to Anti-IL4/13 and ON, Canada4 Anti-IL5 Agents in the Management of Type 2 Asthma Meghan Robbins, The Pennsylvania State University College of Medicine 3801 Environmental, Viral and Pollen Factors in Allergy 2806 Selected Allied Health Cases and Oral Abstract Sessions Sunday, February 28, 2021, 05:10 pm - 06:25 pm 512 Springtime is associated with increases in total indoor fungi and allergenic species concentrations in a pediatric asthma cohort in Saturday, February 27, 2021, 05:10 pm - 06:25 New York City Samuel Cochran, BS1, Adnan Divjan2, Luis Acosta, MD2, Angela pm Lemons, MS3, Brett Green, PhD FAAAAI3, Matthew Perzanowski, 506 IMPLEMENTATION OF A FOOD ALLERGY WRITTEN AC- PhD2, Karen Dannemiller, PhD1, Ohio State University1, Mailman TION PLAN IN A COMMUNITY-BASED HOSPITAL TO RE- School of Public Health, Columbia University2, NIOSH, Centers DUCE THE INCIDENCE OF FOOD-INDUCED for Disease Control and Prevention3 ANAPHYLAXIS IN PEDIATRIC POPULATION 12 MONTHS 513 Effect modification of the association between domestic mold TO 18YEARS OLD report and wheeze by age and seroatopic predisposition among Data Don-Pedro1, Bamzai Rashi1, Chioma Osemwegie1, Mayela children living in lower-income New York City neighborhoods Duque Blanco1, Vivian Vega1, Olayinka Odetola1, Juhishree Adhi- Adnan Divjan1, Karen Dannemiller, PhD2, Luis Acosta, MD1, Lori kari1, WOODHULL1 Hoepner3, Andrew Rundle, DrPH4, Julie Herbstman, PhD1, Freder- 507 Bridging Knowledge Gaps in Anaphylaxis Management ica Perera, PhD5, Rachel Miller, MD FAAAAI6, Matthew Perza- Through a Video-Based Educational Tool. nowski, PhD1, Columbia University1, Ohio State University2, Jumanah Karim1, Sofianne Gabrielli, MSc2, Bahar Torabi3, SUNY Downstate3, Mailman School of Public Health4, Columbia Adam Byrne, MD4, Sarah De Schryver5, Vanessa Gadoury- Center for Children5, Icahn School of Medicine at Mount Sinai6 Levesque5, Reza Alizadehfar6, Christine McCusker, MD MSc3, 514 Seasonal changes of mite allergen (Der 1) levels in houses with Matthieu Vincent5, Judy Morris7, Jennifer Gerdts8,XunZhang, different architectural styles and ventilation systems PhD5, Moshe Ben-Shoshan, MD FAAAAI3,McGill1, McGill Uni- Hideharu Shirai1, Hiromichi Yamaguchi2, Kohara Yudai3, Makoto versity Health Centre2, Montreal Children3, Children Hospital of Yoshida3, Junko Ishihara4, Jumpei Uchiyama4, Masahiho Sakagu- Eastern Ontario4, Montreal Children Hospital5, MCGill Univer- chi4, Environmental Allergens Info and Care1, Yamaguchi Respira- sity6,HA~f E€ pital du SacrA~f A^Ó-Coeur de MontrA~f A^ 7,FoodAl- tory and Dermatology Clinic2, Ichijo Co., Ltd.3, Azabu lergy Canada8 University4 508 Fractional exhale nitric oxide in children with moderate persis- 515 Commissioning of a Larger Naturalistic Exposure Chamber for tent chronic rhinitis Cat Dander Woralak Sutiratanachai, MD1, Wiparat Manuyakorn, MD, Laura Haya, PhD1, Shawn Somers-Neal2, Rym Mehri2, Zachary PhD2, Watcharoot Kanchongkittiphon, MD PhD3, Nichaporn Huffman2, Stefan Van de Mosselaer1, Suzanne Kelly, PhD3, Bryan Chalermpalanupap, MD1, Cherapat Sasisakulporn1, Potjanee Santone1, Edgar Matida, PhD2, William Yang, MD FAAAAI1, Red Kiewngam1, Wanlapa Jotikasthira1, Mahidol University1,Ram- Maple Trials1, Carleton University2, Red Maple Trials Inc.3 athibodi Hospital2, Washington University School of 516 Association Of Dog Exposure and Early-Life IgE Production In Medicine3 The Microbes, Asthma, Allergy and Pets (MAAP) Birth Cohort 509 Cost Assessment Of Allergy Procedures To Improve High Value Ahmed Elisa1, Abigail Chatfield1, Suzanne Havstad, MA1, Alexan- Care Implementation dra Sitarik1, Haejin Kim, MD1, Kyra Jones2, Ganesa Wegienka, Catherine Popadiuk1, Maria Paula Henao, MD2, Jennifer Kra- PhD FAAAAI1, Christine Joseph, PhD1, Nicholas Lukacs, PhD3, schenewski, MD3, Edeanya Agbese, MPH3, Doug Leslie, PhD3, Christine Johnson1, Dennis Ownby, MD FAAAAI4, Susan Lynch, Penn State Milton S. Hershey Medical Center1, Penn State Her- PhD5, Edward Zoratti, MD FAAAAI6, Henry Ford Health System1, shey Medical Center2, Penn State Milton S Hershey Medical Henry Ford Health Systems2, University of Michigan Medical Center3 School3, Augusta University4, Asthma, Immunology & Allergy As- 510 Management of a Immunotherapy Unit During the soc5, Henry Ford Hospital6 COVID-19 Outbreak: Building a Resilient Health Care 517 Inhaled Nicotine Salt Counteranions Induce Airway Inflamma- System. tion and Promote a Neutrophilic Asthma Phenotype Inmaculada Sanchez-Machin, MD PhD1, Ruperto Gonzalez Robert Immormino, PhD1, Bridger Scoggins2, Timothy Moran, Perez, MD PhD1, Paloma Poza Guedes, MD PhD2,Cristina MD PhD1, University of North Carolina School of Medicine1, Uni- Alava Cruz, MD1, Elena Mederos Luis1, Victor Matheu, versity of North Carolina-Chapel Hill2 AB206 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2021

518 Loss of sense of smells associated with sour taste is a possible School Medicine4, Johns Hopkins Hospital5, Johns Hopkins6, Johns diagnostic marker for COVID-19 Hopkins University7, NIAID/NIH8, John Hopkins Hospital9 Mohammad Asad, PhD1, Esha Sehanobish, PhD1, Valerie Fong1, 525 Transcriptomic and Gene Set Enrichment Analysis of Peanut Meaghan O’Neill1, Viraj Patel1, Danielle Bottalico1, Merhunisa stimulated CD4+ T cells during Peanut Oral Immunotherapy Karagic1, Denisa Ferastraoaru, MD1, Inessa Gendlina1,MaliBarbi1, Yamini Virkud, MD FAAAAI1, Bert Ruiter, PhD1, Neal Smith2, Meryl Kravitz1, Cynthia Matsumura1, Denise Tejera1, Golda Hudes, David Pyle, MD PhD1, Sarita Patil, MD FAAAAI1, Wayne Shref- MD PhD1, Nadeem Akbar1, Avindra Nath2, Bryan Smith2, Thomas fler, MD PhD FAAAAI3, Massachusetts General Hospital1, Center Ow1,ElinaJerschow,MDFAAAAI3, Albert Einstein College of for Immunology & Inflammatory Dis2, Massachusetts General Hos- Medicine/Montefiore Medical Center, Bronx, NY1, National Institute pital / Harvard3 for Neurologic Disorders and Stroke, National Institutes of Health, 526 Basophil activation tests identify a peanut OIT subgroup with Bethesda, MD2, Albert Einstein College of Medicine3 improved safety and outcomes 519 Integrative Proteomics and Phosphoproteomics of Asthmatic Sharon Chinthrajah, MD1, Shu Cao1, Mindy Tsai2, Kaori Mukai, Airways following RV Infection. PhD3, Robert Tibshirani, PhD4, Sayantani Sindher, MD1, Kari Na- Joshua Kennedy, MD FAAAAI1, Katherine Caid1, Suzanne House, deau, MD PhD FAAAAI5, Stephen Galli, MD6, Stanford University BS1,ClairePutt2, Nathan Avaritt, PhD1, Stephanie Byrum, PhD1, - Sean N. Parker Center for Allergy and Asthma Research1, Stan- Alan Tackett, PhD1, Richard Kurten, PhD1, University of Arkansas ford University - Pathology Sponsored Projects2, Stanford Univer- for Medical Sciences1, University of Arkansas for Medical Scien2 sity - Department of Pathology3, Stanford University - 520 Recent Common Cold Does Not Reliably Protect from Re-Infec- Biomedical Data Science and of Statistics4, Stanford Univ School tion and Fails to Cross-Protect Fifteen Weeks Later, Despite In- Medicine5, Stanford University - Department of Pathology, Stan- volvement of Cross-Reactive T Cells ford University, Stanford6 Lyndsey Muehling, PhD1, Ronald Turner, MD1, Alberta Paul, 527 Transcriptomics Of Gastrointestinal Biopsies During Oral Im- PhD2, Cheree Denby-Taylor1, William Kwok, PhD3, Judith Wood- munotherapy Reveals Changes In IgA Pathway folk, MBChB PhD FAAAAI1, University of Virginia1, University of Gopal Krishna Dhondalay, PhD1, Wenming Zhang, PhD2, Ra- Virginia (Former)2, Benaroya Research Institute3 mona Hoh, PhD3, Neeraja Kambham2, Scott Boyd, MD,PhD2, San- dra Andorf, PhD4, Monali Manohar, PhD5, Sharon Chinthrajah, MD3, Kari Nadeau, MD PhD FAAAAI6, Sean N Parker Centre for Allergy & Asthma R1, Stanford University2, Stanford3, Univer- 3802 A Display of the Wide Scope of Food Allergy sity of Cincinnati College of Medicine4, Stanford Univesity5, Stan- ford Univ School Medicine6 and Eosinophilic Disorders 528 Presence of Ara h 2, the major peanut allergen, in human milk Amy Burris1, Nichole Diaz, BA2, Antti Seppo, PhD2, Kirsi Jarvi- nen-Seppo, MD PhD FAAAAI3, Univeristy of Rochester Medical 1 2 Sunday, February 28, 2021, 05:10 pm - 06:25 pm Center , University of Rochester Medical Center , University of Rochester Medical Center,3 521 Development of an Antigen-Specific T Cell Assay to Identify 529 Differential Contribution Of TNFSF14/LIGHT-Receptor Medi- Food Triggers in Eosinophilic Esophagitis ated Pathways To Inflammatory Fibroblast Phenotypes In Eo- 1 1 1 Julianna Dilollo , Elizabeth Martin , David Hill, MD, PhD , Jon- sinophilic Esophagitis 2 1 athan Spergel, MD, PhD , The Children’s Hospital of Philadelphia , Mario Cabrero Manresa1, Elaine Pham2, Loan Duong3, Haruka 2 Children Hospital of Philadelphia Miki4, Michael Croft5, Seema Aceves, MD PhD FAAAAI6, Univer- 522 Effect on age on clinical and immunologic efficacy of peanut sity of California San Diego1, UNIVERSITY CALIFORNIA SAN sublingual immunotherapy DIEGO2, UCSD3, La Jolla Institute for Immunology4, La Jolla In- 1 1 2 Olivia Francis , Michael Kulis, PhD , Ping Ye , Edwin Kim, MD stitute5, University of California, San Diego6 MS FAAAAI3, UNC Chapel Hill1, University of North Carolin at Chapel Hi2, University of North Carolina School of Medicine3 523 The Influence of Early and Continuous Exposure of Infants to Cow’s Milk Formula on The Occurance of Milk Allergy 1 2 1 Idit Lachover-Roth , Anat Cohen - Engler , Yossi Rosman, MD , 3803 Telemedicine and Beyond: Let’s Make our Keren Meir-Shafrir2, Yael Furman3, Tal Biron-Shental4, Ronit Con- fino-Cohen4, Meir Medical Center, Kfar Saba, Israel. Sackler Practices Better! School of Medicine, Tel Aviv University, Israel1, Meir Medical Center, Kfar-Saba, Israel2, Meir Medical Center, Kfar-Saba, Israel. Sackler School of Medicine, Tel Aviv University, Israel3, Meir Medical Center, Kfar-Saba, Israel. Sackler School of Medicine, Sunday, February 28, 2021, 05:10 pm - 06:25 pm Tel Aviv University, Israel4 530 Attitudes Among Faculty Members and Trainees About the Ef- 524 Rates of Peanut Discontinuation After Introduction Among fects of Telemedicine on Clinical Education During COVID-19 High-Risk Infants Patrick Gleeson1, Di Sun, MD MPH2, Jennifer Heimall, MD Abhilasha Banerjee1, Michael Pistiner, MD MMSc2, Wayne FAAAAI3, Olajumoke Fadugba, MD1, Hospital of the University Shreffler, MD PhD FAAAAI3, Robert Wood, MD4, Joan Dunlop, of Pennsylvania1, Children’s Hospital of Philadelphia2, CHOP3 MD5, Jennifer Dantzer, MD6, Mihaela Plesa6, Daria Szelag, 531 Identifying Baseline Differences in Autonomy in Patients with PNP7, Roger Peng6, Alkis Togias, MD FAAAAI8, Corinne Keet, Moderate-Severe Asthma MD MS PhD9, Johns Hopkins Department of Allergy and Immu- Timothy Buckey, MD, MBE1, Knashawn Morales, ScD2, Andrea nology1, MassGeneral Hospital for Children, Harva2, Massachu- Apter, MD MA MSc FAAAAI2, Temple University Hospital1, Uni- setts General Hospital / Harvard3, Johns Hopkins University versity of Pennsylvania2 J ALLERGY CLIN IMMUNOL Abstracts AB207 VOLUME 147, NUMBER 2

532 Improving Drug Allergy Education Among Internal Medicine Brazil1, Ribeir~ao Preto Medical School, University of S~ao Paulo, Residents Ribeir~ao Preto, SP, Brazil2, University of Sao Paulo, Ribeir~ao Preto, Darya Koenig1, Santiago Alvarez-Arango, MD1, N. Franklin Ad- SP, Brazil3 kinson, MD FAAAAI2, Johns Hopkins University1, Johns Hopkins 540 Safe Subcutaneous Immunotherapy Dosing Adjustments Following Asthma and Allergy Center2 Prolonged Interruptions In Therapy Due To Covid-19 Pandemic. 533 COVID-19 Pandemic and Telehealth: allergy patient perspec- Lois Kang, Maya Goldman1, Anny Uyehara, NP1, Michael Goldman, tives in an urban, academic medical center MD FAAAAI2, Allergy & Asthma Center of Central Maryland1,Allergy Darshil Patel1, Andrea Pappalardo, MD FAAAAI1, Vanessa Har- & Asthma Center of Central Maryl2 mon2, Mary Pasquinelli1, Julia Trosman3, Christine Weldon4, Shar- 541 Role of Acid-sensing Ion Channel 1 in sensing acidification and milee Nyenhuis, MD FAAAAI1, University of Illinois at Chicago1, triggering inflammation in Nasal Polyps with Asthma University of Illinois Hospital and Health Sciences System2, center Hai Lin1, Guang-Yi Ba1, Ru Tang1, Ming-Xian Li2, Wei-Tian for business models3, Center for Business Models in Healthcare4 Zhang1, Shanghai Sixth People’s Hospital1, Shanghai Sixth Peo- 534 Methods for Identifying and Reconciling Allergy Information in ple’s Hospital2 the Electronic Health Record 542 Non-specific Lipid Transfer Protein (Can s 3) Is a Relevant Carlos Ortega1, Ying-Chih Lo, MD, PhD2, Suzanne Blackley, Cannabis Allergen in North America MA3, Sachin Vallamkonda4, Frank Chang3, Oliver James3, Sharmi- Henry Morelli1, Cathy Thorpe2, Ine Decuyper, MD PhD3, Cali Lo- tha Yerneni1, Diane Seger, RPh3, Liqin Wang, PhD2, Kimberly Blu- blundo1, Khaldon Abbas, Premedical Student4, Didier Ebo, MD menthal, MD MSc FAAAAI5, Foster Goss, DO, MMSc6, Paige PhD FAAAAI5, Gordon Sussman, MD FAAAAI6, Martin Chap- Wickner, MD FAAAAI2, Li Zhou, MD, PhD2, Brigham and man, PhD FAAAAI7, Ajay Nayak, PhD1, Thomas Jefferson Univer- Women’s Hospital, Boston, MA1, Brigham and Women’s Hospital, sity1, INDOOR Biotechnologies Inc.2, University of Antwerp3, Harvard Medical School, Boston, MA2, Mass General Brigham, University of British Columbia4, University Antwerp5, University Boston, MA3, Brigham and Women’s Hospital, Boston, MA4, Mas- of Toronto6, Indoor Biotechnologies, Inc.7 sachusetts General Hospital, Harvard Medical School, Boston, 543 Temporal Trends of Skin Prick Tests MA5, University of Colorado Hospital, University of Colorado Pasquale Mule1, Bruce Mazer, MD FAAAAI1, Danbing Ke, PhD1, School of Medicine, Aurora, CO6 Duncan Lejtenyi, MSc1, Liane Beaudette, RN1, Julia Upton, MD2,Ed- 535 Test-dose as a De-labeling Tool in Patients with Self-reported mond Chan, MD FAAAAI3,AnnClarke4, Sofianne Gabrielli, MSc1, Sulfonamide Allergy: A Quality Improvement Project Moshe Ben-Shoshan, MD FAAAAI1, Division of Allergy and Clinical Gabriel Motoa Cardona1, Ismael Carrillo-Martin, MD1, Jared Immunology, Department of Pediatrics, Montreal Children’s Hospital, Nelson, DO1, Wendelyn Bosch, MD1, Justin Oring1, Miguel Park, McGill University Health Centre, Montreal, QC, Canada1,Divisionof MD1, Alexei Gonzalez-Estrada, MD1, Mayo Clinic1 Immunology and Allergy, Department of Pediatrics, The Hospital for 536 Web-based Infant Food Introduction (WIFI): Improving Access Sick Children, Department of Paediatrics, University of Toronto, Tor- to Allergist-supervised Infant Food Introduction. onto, ON, Canada2, Division of Allergy and Immunology, Department Meriem Latrous1, Rongbo Zhu, MD2, Samira Jeimy, MD PhD2, of Pediatrics, BC Children’s Hospital, University of British Columbia, Douglas Mack, MD3, Lianne Soller, PhD1, Edmond Chan, MD Vancouver, British Columbia, Canada3, Division of Rheumatology, FAAAAI1, Jennifer Protudjer, PhD4, Mariam Hanna, MD3, Elissa Department of Medicine, Cumming School of Medicine, University Abrams, MD FRCPC4, Victoria Cook, MD1, Scott Cameron, MD of Calgary, Calgary, Alberta, Canada4 PhD1, Stephanie Erdle, MD1, Tiffany Wong, MD1, University of 544 Intranasal Ketorolac, Diagnosis and Desensitization for Aspirin British Columbia1, Western University2, McMaster University3, Exacerbated Respiratory Disease (AERD) University of Manitoba4 Amie Nguyen1, Bruce Zuraw, MD2, Christina Wu, MD3, Alexander 537 An Institutional Survey of Patient Satisfaction with Telemedicine Kim, MD2, Sandra Christiansen, MD2, Kaiser Permanente Los An- Services in Pediatric Allergy During the COVID-19 Pandemic geles Medical Center1, UCSD2, USCD3 Kasey Lanier1, Merin Kuruvilla, MD1,JenniferShih,MD 545 Systemic Reaction Rates in Subcutaneous Immunotherapy Pa- FAAAAI1, Emory University School of Medicine1 tients Monitored Outside of Clinic 538 Clinical Documentation of Peanut Allergy Prevention in an Ac- Alyssa Osheim1, Julia Smith1, Greater Austin Allergy, Asthma and ademic Learning Health System Immunology1 Edward Iglesia, MD1, Hunter Smith, MPH1, Edwin Kim, MD MS 546 EDS-FLU (Exhalation Delivery System With Fluticasone) is As- FAAAAI1, Michelle Hernandez, MD FAAAAI1, University of sociated With Improved Sleep in Patients With Nasal Polyposis North Carolina School of Medicine1 Anuja Kapil, MD1, Harry Sacks, MD2, John Messina, PharmD2, Mahboobeh Mahdavinia, MD PhD FAAAAI1, Rush Medical College, Rush University, Chicago, IL1, OptiNose US, Inc. Yardley, PA2

3804 The Best of Immunotherapy, Rhinosinusitis, Nasal Polyposis and Allergy Diagnostics 3805 Immune Regulation of the Allergic Response: Novel Insights Sunday, February 28, 2021, 05:10 pm - 06:25 pm 539 Effect of house dust mite sublingual immunotherapy in patients with Atopic Dermatitis: a randomized, double-blind, placebo- controlled clinical trial Sunday, February 28, 2021, 05:10 pm - 06:25 pm Sarah Langer1, Janaina Melo, PhD,MD1, Renata Cardili, PhD, 548 Staphylococcus aureus Increases Rhinovirus Replication and MD1, Roberto Bueno, PhD, MD2, Mariana Ferriani, PhD, MD1, Synergistically Enhances Cytotoxicity During Co-infection of Adriana Moreno, PhD3, Fabio Carmona, PhD, MD2, Jorgete Silva, the Airway Epithelium PhD, MD1, Persio Roxo, PhD, MD2, Davi Aragon, PhD2, Luisa Eishika Dissanayake1, Rebecca Brockman-Schneider2, Reed Stub- Karla Arruda, MD PhD FAAAAI2, Ribeir~ao Preto Medical School bendieck2, Cameron Currie2, James Gern, MD2, University of Wis- Clinical Hospital, University of S~ao Paulo, Ribeir~ao Preto, SP, consin - Madison1, University of Wisconsin-Madison2 AB208 Abstracts J ALLERGY CLIN IMMUNOL FEBRUARY 2021

549 Cyclic-Di-GMP promotes STING-dependent ILC2 to ILC1 shift MD FAAAAI1, Shehzad Sheikh, MD, PhD1, University of North and abrogates eosinophilia in ILC2-driven lung inflammation Carolina at Chapel Hill1 Kellen Cavagnero1, Jana Badrani1, Luay Naji1, Michael Amadeo1, 554 The Major Cat Allergen, Fel d 1, Is a Viable Target for CRISPR Anthea Leng1, Lee Lacasa1, Alyssa Strohm1, Taylor Doherty, MD Gene Editing. FAAAAI1, University of California, San Diego1 Nicole Brackett1, Anna Pomes, PhD FAAAAI1, Martin Chapman, 550 CD69+ Th2-type CD4+ T Cells are Responsible for Long-term PhD FAAAAI1, Indoor Biotechnologies, Inc.1 Memory Responses to Allergens in the Lungs 555 Dysregulation of Circulating Monocytes is Associated with Takao Kobayashi, PhD1, Koji Iijima, PhD1, Jyoti Lama1, Hirohito Exposure to Air Pollution and Asthma in Children Kita, MD1, Mayo Clinic Arizona1 Hesam Movassagh1, Mary Prunicki, MD PhD1,EricSmith2, 551 Human IgE monoclonal antibodies define the molecular basis of Diane Dunham2, Xiaoying Zhou1,GermanAlemanMuench3, red meat allergy Pejman Soroosh, PhD3, Kari Nadeau, MD PhD FAAAAI4, Scott Smith, MD PhD1, Azadeh Hadadianpour2, Joshua Dolye1, Stanford University1, Sean N Parker Center for Allergy Kelly Boyd1, Ryan McBride3, James Paulson, PhD3, Vanderbilt and Asthma Research, Stanford School of Medicine2, University Medical Center1, Vanderbilt University2, The Scripps Janssen Research and Development3, Stanford Univ School Research Institute3 Medicine4 552 Air pollutant exposure induces peanut allergy in an animal model 556 Activation of TLR3 Inhibits Innate Type 2 Immune Responses Timothy Moran, MD PhD1, Johanna Smeekens, PhD1, Robert Immor- through the Interferon-beta Pathway mino, PhD1, Zach Allen2,AndrewGhio,MD3, Michael Kulis, PhD1, Rinna Tei, MD1,KojiIijima,PhD1, Takao Kobayashi, PhD1, University of North Carolina School of Medicine1, University of North Hirohito Kita, MD1, Mayo Clinic Arizona1, Biothechnology, Carolina-Chapel Hill2, US Environmental Protection Agency3 Moscow, Russia2, All-Russian Research Institute of Dairy In- 553 Intestinal Barrier Dysfunction Accompanies Peanut Allergy in dustry, Moscow, Russia3, George Washington University CC027/GeniUnc Mice School of Medicine, Washington, DC, USA; Immunology Erin Steinbach, MD PhD1, Johanna Smeekens, PhD1, Layna Research Institute of New England, Gardner, MA, Perini1, Satyaki Roy, PhD1, Ana Berglind1, Michael Kulis, PhD1, USA4 Martin Ferris, PhD1, Terrence Furey, PhD1, A. Wesley Burks,