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Diabetesawarenessmonth Page 3 NEWSNOTES CHILDREN’S DIABETES FOUNDATION - FALL 2019 #DIABETESAWARENESSMONTH PAGE 3 OLIVIA’S GARDEN AT BDC PAGE 14 Active kids put the system to the test PAGE 2 NEWSNOTES Children’s Diabetes Foundation FEATURES Board Members EXECUTIVE BOARD: SCIENTIFIC ADVISORY BOARD: 5 RUN FOR THE RING 5K & FUN RUN Mrs. Barbara Davis, Chairman Richard S. Abrams, M.D. Dana Davis, Executive Director Director, Colorado Preventive Mr. Cameron van Orman, Vice Medicine, Rose Medical Center; 8 CHARLOTTE TUCKER Chairman Clinical Professor of Medicine UCD Richard S. Abrams, M.D. Mark Atkinson, Ph.D. SCHOLARSHIP RECIPIENTS Professor of Pathology & Pediatrics, Stephen Daniels, M.D., Ph.D. Director, University of Florida Chairman of Pediatrics Diabetes Institute The Children’s Hospital, Denver Ezio Bonifacio, Ph.D. 11 BONE HEALTH IN TYPE 1 DIABETES Mrs. Nancy Davis Rickel Professor for Preclinical Approaches Steven Farber, Esq. to Stem Cell Therapy, Daniel Feiten, M.D. Center for Regenerative Therapies, Dresden, Germany 15 OLIVIA’S GARDEN AT BDC Mr. Shane Hendryson Robert Eckel, MD Mrs. Arlene Hirschfeld Professor of Medicine, Physiology and Mrs. Deidre Hunter Biophysics, University of Colorado 19 UPCOMING EVENTS Mr. Shawn Hunter School of Medicine Mr. Steve Lucas Matthias Hebrok, Ph.D. Professor in Residence and Director, Mrs. Tracy van Orman Diabetes Center, University of 20 1 SWEET CRUISE Mr. Ken Rickel California, San Francisco John J. Reilly, Jr., M.D. Steven Kahn, MB, Ch.B. Vice Chancellor for Health Affairs Professor of Medicine, Director of the 21 2019 CAROUSEL BALL & Dean, School of Medicine, Diabetes Research Center, University University of Colorado Denver of Washington Mrs. Stacy Mendelson Robinson Rudolph Leibel, MD Professor of Pediatrics and Medicine, Marian Rewers, M.D., Ph.D. Co-Director, Naomi Berrie Diabetes Ex-Officio Member Center, Columbia University Alvin Powers, MD Professor of Medicine, Molecular Physiology/Biophysics, Division Director, Vanderbilt University William Tamborlane, MD Professor of Pediatrics, Yale University School of Medicine NewsNotes is published quarterly by the Children’s Diabetes Foundation. If you would like to submit an article or a letter to NewsNotes, send information to [email protected]. Zachary Reece, Graphic Designer Brent McDaniel & Dana Davis, Editors Photo: © www.JensenSutta.com Facebook.com/ @CDFdiabetes @CDFdiabetes ChildrensDiabetesFoundation [email protected] 303-863-1200 • 4380 S. Syracuse St., Ste. 430 Denver, CO 80237 2 NOVEMBER IS #DIABETESAWARENESSMONTH #DiabetesAwarenessMonth is the perfect time to start a conversation with someone about your type 1 diabetes. Talk to a family member, friend, or coworker about type 1 diabetes – you never know what questions they might have, even if they’ve known you since your diagnosis. Share your daily management routine or explain the differences between type 1 and 2. When you take the time to share about type 1, we all become better allies in the search for the cure. All during November, wear blue – the color for diabetes awareness – to show your support. Don’t forget to use #DiabetesAwarenessMonth and tag CDF in your photos, stories, and posts this November. #DIABETESAWARENESSMONTH Facebook.com/ @CDFdiabetes @CDFdiabetes ChildrensDiabetesFoundation And what better way to cap off #DiabetesAwarenessMonth than to schedule your donation to Children’s Diabetes Foundation for Colorado Gives Day! Starting November 1st, visit ColoradoGives.org/CDF to schedule your gift for the big day, December 10, 2019. 3 5TH ANNUAL RUN FOR THE RING On Saturday, August 3rd the 5th Annual Run for the Ring 5K and Kids Fun Run presented by Empower Retirement was held at the Barbara Davis Center for Diabetes on the beautiful University of Colorado Anschutz Medical Campus. More than 360 runners, walkers, strollers, and participants of all ages came together in support of reaching the brass ring - the cure for type 1 diabetes. Fun Run has their own track, splash zones, bounce house, balloon twisting, face painting, and a foam party that will not be forgotten! Teams were a huge hit this year with 21 race groups that created their own shirts, wore costumes, and enjoyed the Team Village. Congratulations to Dr. Lori Sussel’s Team, The Barbara Davis Center Research Division, for winning the largest team with 36 members! First place finishers for our 7 divisions were given medals at the awards ceremony presented by Dexcom. Sarah Johannes was our largest individual fundraiser with more than $2,385 in donations honoring her daughter who was diagnosed 7 months ago. Special thanks to Runner’s Roost for donating a $100 gift card for each of the overall male and female winners, Bladium Sports & Fitness for donating the 2-hour team building prize package, and Elvis Cinemas for providing family movie passes for the top fundraiser. Thank you to our generous sponsors 106.7 The Bull, iHeart Media, Transcend, Dexcom, Denver Kids Out and About, Eldorado Springs, Caribou Coffee, Einstein’s Bagels, and META MVMT for your participation. Run for the Ring is made possible by our incredible volunteers and community: Chairman Katie Grassby, DJ Chelsea Thomas, Emcee Buzz Sweat, Wheat Ridge Poms, Thunder Ridge Poms and Lacrosse teams, Paige Trumble, and Aurora Fire Rescue. A special thanks to our committee: Christy Alberts, Analisa Clealand, Lori Finch, Kate Frost, Cheryl Lebsock, Lyn Schaffer, Juli Smolen, and Christy Vasey. We truly couldn’t do it without you! 4 Photos: © Jared Wilson Photography DIABETES NEWS FDA APPROVAL OF NASAL GLUCAGON AND WHAT IT MEANS FOR PEOPLE WITH DIABETES BY R. PAUL WADWA, MD On July 24, 2019, the FDA approved intranasal glucagon Who can use it? (Baqsimi, pronounced “back-see-mee”) for patients with The product is approved by the FDA for people with diabetes mellitus ages 4 years and over. This is big news, diabetes mellitus ages 4 years and over. At this time, it is not but it raises many questions at this time. We will try to approved for use in Europe or Canada, but authorities are cover some of these here and hopefully answers to others reviewing the new formulation. In the United States, the will become more clear very soon. product is being released to pharmacies in early to mid- August 2019. First, what is glucagon? Glucagon is a hormone made by the body which When should it be used? 4. normally acts as a counter balance to insulin. A synthetic Baqsimi should be used to treat severe hypoglycemia. The version of glucagon has been available for several device is single use and is just available in one strength (3 decades in an emergency injection kit for the treatment mg), so only one full dose is given with the device. The of severe hypoglycemia. Because this form of glucagon is dose may not be decreased. It should be used in cases of not stable in liquid form, the kit contained a powder that low blood sugar with loss of consciousness or seizure. It is had to be mixed with a diluent and then drawn up into a not intended for “low dose” use or for self-treatment. The syringe before given as a subcutaneous or intramuscular side effects seen with nasal glucagon include the same side injection. Injection of the synthetic glucagon causes effects seen with injectable glucagon (nausea, vomiting, glycogen from the liver to be broken down and glucose is headache) and also symptoms of nasal irritation or released into the blood stream to raise the blood sugar. discomfort and irritated or watery eyes. What is Baqsimi? What is the cost? Baqsimi is a new form of glucagon from Eli Lilly and This is difficult to answer right now. Eli Lilly is still Company. It is the first glucagon that does not require working with insurance carriers to get nasal glucagon on an injection and it can be administered in the nose. It formularies. They are also offering discount cards but these will come as a fine powder within in a single-use device have some restrictions such as a requirement for private to administer the drug in the nostril where it will be insurance. That means patients with Medicaid, Medicare absorbed in the nasal lining. and Tricare insurance would not be eligible for the discount cards. Paying out of pocket will be expensive. The cost is about the same as the injectable glucagon, which is around $300 for a kit (depending on the pharmacy). For more information about discount cards see www.Baqsimi.com. In summary, this new formulation of glucagon will be easier to administer than the current injectable glucagon emergency kits in the case of a severe hypoglycemic event. This should translate to improved administration and could No inhalation is required. be life-saving for people with diabetes requiring urgent A person administering glucagon inserts the tip of the treatment for severe low blood sugars. device into the nostril of the person in need of glucagon and pushes a button on the bottom of the device. The Disclosures: Dr. Wadwa serves on an advisory board for Eli Lilly and receives research spring loaded mechanism will release the powder and support for a clinical trial initiated by Eli Lilly and unrelated to nasal the drug will be absorbed in the nasal lining with no glucagon. inhalation required. Research studies documenting the effectiveness of the new formulation include two studies in adults with diabetes and one pediatric study. Two of these three studies included the Barbara Davis Center as one of the sites conducting the trials. 5 CYCLING FOR A CURE BY SARAH SCOTT This July, my mom, Mary Scott, and I rode our bikes from Buffalo to Syracuse, New York. I have been riding more and more over the past few years and have shared my adventures, challenges, and learning with mom. Mom decided that riding the Erie Canal would be the perfect first multi-day ride and we rode with my parent’s friends, Nicole and Bill Cooper and Cindy O’Connor.
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