Polyclonal Antibody (DPABH-22979) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Magic™ Anti-SMAD1 (Phospho S206) polyclonal antibody (DPABH-22979) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Antigen Description Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.

Specificity DPABH-22979 is specific for Human Smad1 phosphorylated at pS206. Reactivity with nonphosphorylated Human Smad1 is minimal by ELISA and western blot.

Target SMAD1

Immunogen A phosphorylated synthetic peptide corresponding to amino acids surrounding serine 206 of Human Smad1.

Isotype IgG

Source/Host Rabbit

Species Reactivity Human

Purification Immunogen affinity purified

Conjugate Unconjugated

Applications WB, ELISA

Procedure Phospho-specific Antibodies

Format Liquid

Size 100 μg

Buffer pH: 7.20; Constituents: 0.42% Potassium phosphate, 0.88% Sodium chloride

Preservative 0.01% Sodium Azide

Storage Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

GENE INFORMATION

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Official Symbol SMAD1

Synonyms SMAD1; SMAD family member 1; BSP1; JV41; BSP-1; JV4-1; MADH1; MADR1; mothers against decapentaplegic homolog 1; MAD homolog 1; Mad-related protein 1; TGF-beta signaling protein 1; mothers against DPP homolog 1; SMAD, mothers against DPP homolog 1; MAD, mothers against decapentaplegic homolog 1; transforming growth factor-beta signaling protein 1; transforming growth factor-beta-signaling protein 1;

Entrez Gene ID 4086

Protein Refseq NP_001003688.1

UniProt ID Q15797

Pathway ALK1 signaling events; Angiogenesis; BMP signalling and regulation; ErbB1 downstream signaling

Function I-SMAD binding; RNA polymerase II core promoter sequence-specific DNA binding; co-SMAD binding; identical protein binding

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]