Revolutionary methodology free from BIOTIN-STREPTAVIDIN

Randox Biochip Array Technology

Biotin - A5.indd 1 24/07/2018 16:38 Introduction

The recent increase in popularity of biotin containing supplements to promote healthy hair, skin and nails has led to major concerns relating to its potential impact on diagnostic test results. Many immunoassay tests utilize the biotin-streptavidin method, where microparticles coated with streptavidin capture biotin which in turn is attached to the target antibody. The problem arises when excess biotin in the patient sample interferes with the streptavidin coated microparticles ability to capture the target analyte, leading to falsely elevated or falsely lowered results and ultimately misdiagnosis.

The Solution – Biochip Array Technology

Revolutionary Biochip Array Technology from Randox does not employ the biotin-streptavidin method, increasing confidence in your laboratory’s immunoassay test results.

Biochip Array Technology enables the simultaneous/multiplex detection of a wide range of analytes from a single patient sample ultimately producing a complete patient profile for more informed diagnosis. Additional benefits include: • Excellent correlation to gold standard methods • Reduced costs and time owing to the multiplex nature of the method • Small sample volume • Multiple sample matrices

Evidence Series of Immunoassay Analyzers

Evidence Investigator Evidence Semi-automated Fully automated immunoanalyzer capable immunoanalyzer of 3960 tests per hour

Evidence Evolution Evidence MultiSTAT Fully automated immunoanalyzer capable Fully automated immunoanalyzer providing results of 2640 tests per hour for up to 21 drugs of abuse in under 20 minutes

Biotin - A5.indd 2 24/07/2018 16:38 Test Menu

Adhesion Molecules Progesterone Barbiturates E-Selectin Prolactin Benzodiazepines I (Oxazepam) Intercellular Adhesion Molecule-I – ICAM-I Sex Hormone Binding Globulin − SHBG Benzodiazepines II (Lorazepam) L-Selectin Testosterone BZG/Cocaine P-Selectin Buprenorphine Vascular Cell Adhesion Molecule-I – VCAM-I Gastrointestinal Benzylpiperazines (BZP) Gastrin 17 − GI7 Cannabinoids (THC) Alzheimer’s Helicobacter pylori − H. pylori Carfentanil/Remifentanil Apolipoprotein E4 – ApoE4 Pepsinogen I − PGI Chloral Hydrate Metabolite Pan Apolipoprotein E – Apo E Pepsinogen II − PGII Clonazepam Creatinine Anaemia Metabolic Dextromethorphan Ferritin Adiponectin Escitalopram Folate Ferritin EtG Vitamin BI2 Insulin Etizolam Leptin Fentanyl Bone Disease Plasminogen Activator Inhibitor − PAI-1 Flunitrazepam Vitamin D Resistin Fluoxetine Furanyl Fentanyl Cancer Renal Generic Opioids Carcinoembryonic Antigen − CEA Adiponectin Haloperidol Free Prostate Specific Antigen − FPSA Complement C3a des Arginine – C3a des Arg Ibuprofen Total Prostate Specific Antigen − TPSA C-Reactive Protein – CRP JWH - 018 Cystatin C Ketamine Cardiac D-Dimer LSD Cardiac Troponin I – cTnl Epidermal Growth Factor − EGF MDMA Creatine Kinase MB – CKMB Liver Fatty Acid Binding Protein-1 − FABP1 Meperidine Heart-Type Fatty Acid-Binding Protein – FABP3 Interleukin-8 − IL-8 Mephedrone Myoglobin Macrophage Inflammatory Protein-1α − MIP-1α Meprobamate Neutrophil Gelatinase – Associated Lipocalin – NGAL Mescaline Cytokines Soluble Tumour Necrosis Factor Receptor 1 − sTNFR1 Methadone Epidermal Growth Factor − EGF Soluble Tumour Necrosis Factor Receptor 2 − sTNFR2 Methamphetamine Granulocyte Macrophage Colony Stimulating Factor − GM-CSF Methaqualone Interferon-γ − IFN-γ Stroke Methylphenidate / Ritalinic Acid Interleukin-1 alpha − IL-1α Brain-Derived Neurotrophic Factor − BDNF Mitragynine Interleukin-1 beta − IL-1β D-Dimer MT-45 Interleukin-2 − IL-2 Glial Fibrillary Acidic Protein − GFAP Naloxone Interleukin-3 − IL-3 Glutathione S – Transferase Pi – GSTPi Ocfentanyl Interleukin-4 − IL-4 Heart-Type Fatty Acid-Binding Protein – FABP3 Opiate Interleukin-5 − IL 5 Interleukin-6 − IL-6 Oxycodone Interleukin-6 − IL-6 Nucleoside Diphosphate Kinase – NDKA Oxycodone I Interleukin-7 − IL-7 Neuron Specific Enolase − NSE Oxycodone II Interleukin-8 − IL-8 Parkinson Protein 7 − PARK-7 PCP Interleukin-10 − IL-10 Soluble Tumour Necrosis Factor Receptor 1 − sTNFR1 Phenylpiperazine I Interleukin-12p70 − IL-12p70 Phenylpiperazine II Interleukin-13 − IL-13 Thyroid Pregabalin Interleukin-15 − IL 15 Anti-Thyroglobulin − Anti-Tg Propoxyphene Interleukin-23 − IL-23 Anti-Thyroid Peroxidase − Anti-TPO Salicylate Macrophage Inflammatory Protein-1α − MIP-1α Free Tri-iodothyronine − FT3 Salvinorin Matrix Metalloproteinase 9 − MMP 9 Free Thyroxine − FT4 Sertraline Monocyte Chemotactic Protein-1 − MCP-1 Thyroid Stimulating Hormone − TSH Sufentanil Soluble IL-2 Receptor Alpha − sIL-2Rα Thyroxine Binding Globulin − TBG Tramadol Soluble IL-6 Receptor − sIL-6R Total Tri-iodothyronine − TT3 Trazodone Soluble Tumour Necrosis Factor Receptor 1 − sTNFR1 Total Thyroxine − TT4 Tricyclic Antidepressant Soluble Tumour Necrosis Factor Receptor 2 − sTNFR2 U-47700 Tumour Necrosis Factor-α − TNF-α Tissue Damage UR-144 Vascular Endothelial Growth Factor − VEGF Liver Fatty Acid Binding Protein-1 − FABP1 W-19 Heart-Type Fatty Acid-Binding Protein – FABP3 Zaleplon Diabetes Adipose Fatty Acid Binding Protein – FABP4 Zolpidem Insulin Epidermal Fatty Acid Binding Protein – FABP5 Zopiclone Ileal Fatty Acid Binding Protein – FABP6 α-PVP (Flakka) Endocrine Brain Fatty Acid Binding Protein – FABP7 Cortisol Testis Fatty Acid Binding Protein – FABP9 Dehydroepiandrosterone-Sulphate − DHEAS Toxicology Fibrinolysis 6-MAM D-Dimer AB-CHMINACA AB-PINACA Fertility Acetaminophen Estradiol Acetyl Fentanyl Follicle Stimulating Hormone − FSH AH-7921 Luteinizing Hormone − LH Amphetamine

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