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SUPPLEMENTAL TABLE 2. Results of FDA library screen for Angpt-2 inhibitors

Location Name Conc. (pg/ml) Fold change vs NT 1-A10 Novobiocin Na 5154.7 -1.1 1-A11 Rapamycin 6043.1 1.0 1-A2 Moroxydine HCl 2694.7 -2.2 1-A3 Clindamycin HCl 4562.5 -1.3 1-A4 Clindamycin PO4 3370.5 -1.7 1-A5 Cyclosporin a 948.4 -6.2 1-A6 Donepezil HCl 2801.0 -2.1 1-A7 Lincomycin 3628.6 -1.6 1-A8 Lomofungin 2003.8 -2.9 1-A9 Mycophenolic acid 3583.0 -1.6 1-B10 Pinacidil 5762.2 -1.0 1-B11 Glipizide 5154.7 -1.1 1-B2 Spectinomycin 3309.7 -1.8 1-B3 Bepridil 3742.5 -1.6 1-B4 Amiodarone 546.0 -10.8 1-B5 Nicardipine 629.5 -9.4 1-B6 Pimozide 546.0 -10.8 1-B7 Loperamide 1669.7 -3.5 1-B8 Fluspirilene 819.3 -7.2 1-B9 Tolbutamide 3560.3 -1.7 1-C10 Phenamil 4448.6 -1.3 1-C11 Cirazoline HCl 3985.5 -1.5 1-C2 PhentolamineHCl 3818.4 -1.5 1-C3 Quinine 3848.8 -1.5 1-C4 Flufenamic acid 3006.0 -2.0 1-C5 Propafenone 2474.5 -2.4 1-C6 Phenytoin 2869.3 -2.1 1-C7 Procainamide 3742.5 -1.6 1-C8 Lidocaine 3438.8 -1.7 1-C9 Flecainide 3901.9 -1.5 1-D10 Yohimbine HCl 4015.8 -1.5 1-D11 Dihydroergotamine mesylate 3643.8 -1.6 1-D2 Oxymetazoline HCl 3917.1 -1.5 1-D3 Ifenprodil 3537.5 -1.7 1-D4 Naftopidil 2HCl 3461.6 -1.7 1-D5 Prazosin HCl 2596.0 -2.3 1-D6 Clonidine HCl 2596.0 -2.3 1-D7 Guanabenz acetate 4441.0 -1.3 1-D8 Rilmenidine hemifumarate 3340.1 -1.8 1-D9 Spiroxatrine 4425.8 -1.3 1-E10 sulfate 3211.0 -1.8 1-E11 Pindolol 3362.9 -1.8 1-E2 Nicergoline 6050.7 1.0 1-E3 Emtricitabine 3066.7 -1.9 1-E4 Betaxolol HCl 4061.4 -1.5 1-E5 Practolol 2588.4 -2.3 1-E6 Timolol maleate (s) 2618.8 -2.3 1-E7 Xamoterol hemifumarate 2990.8 -2.0 1-E8 3719.7 -1.6 1-E9 hcl 3454.0 -1.7 1-F10 Ipratropium Br 3211.0 -1.8 1-F11 2HCl 3006.0 -2.0 1-F2 Cimaterol 3362.9 -1.8 1-F3 Dobutamine HCl 2398.6 -2.5 1-F4 Pronethalol HCl 2869.3 -2.1 1-F5 Sotalol HCl 2952.9 -2.0 1-F6 Maprotiline HCl 1198.9 -4.9 1-F7 Nisoxetine HCl 3871.6 -1.5 1-F8 Canthaxanthin 3302.1 -1.8 1-F9 Pilocarpine HCl 2990.8 -2.0 1-G10 Mepyramine maleate 4281.6 -1.4 1-G11 Trans-triprolidine HCl 4046.2 -1.5 1-G2 2HCl 2747.8 -2.1 1-G3 Tropicamide 2656.7 -2.2 1-G4 Pancuronium Br 1988.6 -3.0 1-G5 Ivermectin 583.9 -10.1 1-G6 Physostigmine sulfate 3249.0 -1.8 1-G7 Nialamide 3036.4 -1.9 1-G8 Haloperidol HCl 4236.0 -1.4 1-G9 Piribedil HCl 4031.0 -1.5 1-H10 Riluzole HCl 4661.2 -1.3 1-H11 Propofol 3871.6 -1.5 1-H2 2968.0 -2.0 1-H3 Tiotidine 2823.8 -2.1 1-H4 Zonisamide 2466.9 -2.4 1-H5 Zoledronic acid 3438.8 -1.7 1-H6 Naltrexone HCl 3119.9 -1.9 1-H7 zolmitriptan 3590.6 -1.6 1-H8 Memantine HCl 3446.4 -1.7 1-H9 Aniracetam 3901.9 -1.5 2-A10 Mecamylamine HCl 3494.5 -1.7 2-A11 Neostigmine Br 3206.4 -1.8 2-A2 Mianserin hcl 4661.7 -1.3 2-A3 4011.6 -1.5 2-A4 Furafylline 3391.1 -1.7 2-A5 nateglinide 3546.2 -1.7 2-A6 Isoproterenol HCl (rac) 5585.1 -1.1 2-A7 Acetylcholine Cl 4890.7 -1.2 2-A8 Atropine sulfate 4875.9 -1.2 2-A9 Decamethonium 2Br 4905.5 -1.2 2-B10 Raclopride l-tartrate s(-) 4026.4 -1.5 2-B11 Risperidone 4107.6 -1.4 2-B2 Strychnine HCl 3583.1 -1.6 2-B3 Tubocurarine Cl (+) 4085.5 -1.4 2-B4 Butaclamol (+) 2851.8 -2.1 2-B5 Apomorphine r (-) 2090.9 -2.8 2-B6 Chlorpromazine HCl 3383.7 -1.7 2-B7 Domperidone 4203.7 -1.4 2-B8 Fluphenazine 2HCl 953.2 -6.2 2-B9 Pergolide mesylate 4683.8 -1.3 2-C10 Xylazine HCl 3435.4 -1.7 2-C11 Norepinephrine-(+)-tartrate l (-) 2718.8 -2.2 2-C2 Sulpiride s (-) 2844.4 -2.1 2-C3 Diphenhydramine HCl 4233.2 -1.4 2-C4 Promethazine HCl 2275.6 -2.6 2-C5 HCl 4595.2 -1.3 2-C6 Naltrindole HCl 5031.1 -1.2 2-C7 Idazoxan 3590.5 -1.6 2-C8 Spiperone 2667.1 -2.2 2-C9 Epinephrine-(+)-tartrate l (-) 4676.5 -1.3 2-D10 Vitamin a (acetate) 6656.3 1.1 2-D11 Levallorphan tartrate 4573.0 -1.3 2-D2 Quetiapine fumarate 3176.8 -1.9 2-D3 Alprenolol HCl 4284.9 -1.4 2-D4 Imipramine HCl 5695.9 -1.0 2-D5 Amoxapine 1810.2 -3.3 2-D6 Mesulergine HCl 5843.7 -1.0 2-D7 Amfebutamone 4742.9 -1.2 2-D8 Metoclopramide HCl 3841.7 -1.5 2-D9 Naltriben mesylate 4277.5 -1.4 2-E10 Amorolfine 1403.8 -4.2 2-E11 Clemastine fumarate 1137.9 -5.2 2-E2 Nalbuphine HCl 2925.6 -2.0 2-E3 Carbamylcholine Cl 3538.8 -1.7 2-E4 Carbamyl-beta-methylcholine Cl 4277.5 -1.4 2-E5 Butyrylcholine Cl 4491.8 -1.3 2-E6 3553.6 -1.7 2-E7 Terfenadine 1692.0 -3.5 2-E8 Isoniazid 2910.9 -2.0 2-E9 Ticlopidine HCl 3893.4 -1.5 2-F10 Nisoldipine 2386.4 -2.5 2-F11 Lacidipine 1359.5 -4.3 2-F2 4506.5 -1.3 2-F3 Linezolid 3457.5 -1.7 2-F4 Docetaxil 3021.7 -2.0 2-F5 Olopatadine 3405.8 -1.7 2-F6 Manidipine 1174.8 -5.0 2-F7 Tolcapone 3398.4 -1.7 2-F8 Gestrinone 1802.8 -3.3 2-F9 Olmesartan 2992.1 -2.0 2-G10 Aripiprazole 1322.6 -4.5 2-G11 Candesartan 2918.3 -2.0 2-G2 Olanzapine 2881.3 -2.0 2-G3 Lovastatin 2017.0 -2.9 2-G4 Lamotrigine 4100.2 -1.4 2-G5 Ractopamine 5260.1 -1.1 2-G6 4188.9 -1.4 2-G7 Atovaquone 1366.9 -4.3 2-G8 Sertaconazole 1071.4 -5.5 2-G9 Cefepime 2489.8 -2.4 2-H10 Bopindolol malonate 2962.6 -2.0 2-H11 Guanfacine HCl 4750.3 -1.2 2-H2 Butenafine 561.7 -10.5 2-H3 Dorzolamide 5068.0 -1.2 2-H4 Escitalopram 4883.3 -1.2 2-H5 Eprosartan 4742.9 -1.2 2-H6 Sodium phenylacetate 3841.7 -1.5 2-H7 Ozagrel 4661.7 -1.3 2-H8 Entacapone 2489.8 -2.4 2-H9 Bleomycin sulfate 2445.5 -2.4 3-A10 Gefitinib 817.9 -7.2 3-A11 2616.4 -2.3 3-A2 Tizanidine HCl 9302.1 1.6 3-A3 Meglumine 5431.5 -1.1 3-A4 Propranolol HCl s(-) 5718.2 -1.0 3-A5 Carvedilol 4291.1 -1.4 3-A6 Cerivastatin 4708.2 -1.3 3-A7 Aclarubicin 798.4 -7.4 3-A8 Flumazenil 3926.2 -1.5 3-A9 Fenretinide 4571.3 -1.3 3-B10 Metformin 9360.8 1.6 3-B11 4336.7 -1.4 3-B2 Imatinib 2596.9 -2.3 3-B3 Idarubicin 10553.3 1.8 3-B4 1756.3 -3.4 3-B5 Selegiline 733.2 -8.0 3-B6 Vatalanib 3046.5 -1.9 3-B7 Fumagillin 1938.7 -3.0 3-B8 Efaroxan 5151.3 -1.1 3-B9 Dinoprostone 6545.7 1.1 3-C10 Tacrine HCl 5151.3 -1.1 3-C11 Gallamine triethiodide 7171.3 1.2 3-C2 Dofetilide 3939.2 -1.5 3-C3 Erlotinib 4382.3 -1.3 3-C4 Lobeline 2479.6 -2.4 3-C5 Melatonin 3971.8 -1.5 3-C6 Dinoprost 3313.7 -1.8 3-C7 Fasudil 2851.0 -2.1 3-C8 Hydroxytacrine maleate 3111.7 -1.9 3-C9 Oxotremorine sesquifumarate 4043.5 -1.5 3-D10 Niguldipine HCl 4766.8 -1.2 3-D11 Flunarizine-2HCl 778.8 -7.6 3-D2 Galanthamine HBr 831.0 -7.1 3-D3 Amiloride 4304.1 -1.4 3-D4 Amlodipine 5222.9 -1.1 3-D5 Diltiazem 3698.1 -1.6 3-D6 Nifedipine 4010.9 -1.5 3-D7 Nimodipine 2701.1 -2.2 3-D8 Nitrendipine 4206.4 -1.4 3-D9 Verapamil 4858.0 -1.2 3-E10 Ouabain 2824.9 -2.1 3-E11 Clopamide 1645.5 -3.6 3-E2 Gabapentin 4616.9 -1.3 3-E3 Felodipine 4421.4 -1.3 3-E4 Cilnidipine 1293.6 -4.6 3-E5 Phenoxybenzamine HCl 107.7 -54.7 3-E6 Trifluoperazine 4225.9 -1.4 3-E7 Denbufylline 3333.2 -1.8 3-E8 Miltefosine 2987.9 -2.0 3-E9 Latanoprost 3307.1 -1.8 3-F10 Remoxipride 3971.8 -1.5 3-F11 Calcifediol 3743.7 -1.6 3-F2 Molsidomine 1208.9 -4.9 3-F3 Pravadoline 3913.2 -1.5 3-F4 Tranilast 3913.2 -1.5 3-F5 Shikonin 3235.5 -1.8 3-F6 Bromocriptine mesylate 3424.4 -1.7 3-F7 Clozapine 3352.8 -1.8 3-F8 Clothiapine 4102.1 -1.4 3-F9 Quinpirole HCl (-)- 3033.5 -1.9 3-G10 Indomethacin 10436.0 1.8 3-G11 Naproxen 3984.8 -1.5 3-G2 Calcitriol 4063.0 -1.5 3-G3 Ketoconazole 4532.2 -1.3 3-G4 Oxatomide 4212.9 -1.4 3-G5 Disodium cromoglycate 4167.3 -1.4 3-G6 Capsaicin 3196.4 -1.8 3-G7 Dexamethasone 2805.4 -2.1 3-G8 5535.7 -1.1 3-G9 Ethacrynic acid 5802.9 -1.0 3-H10 Captopril 94.6 -62.3 3-H11 Docebenone 348.8 -16.9 3-H2 Clofibrate 6728.2 1.1 3-H3 Ibuprofen 3997.9 -1.5 3-H4 Benserazide HCl 3698.1 -1.6 3-H5 Debrisoquin sulfate 4597.4 -1.3 3-H6 Methiothepin maleate 4076.1 -1.4 3-H7 Bumetanide 3020.4 -2.0 3-H8 Neomycin sulfate 4219.4 -1.4 3-H9 Auranofin 2961.8 -2.0 4-A10 Terbinafine HCl 5329.8 -1.1 4-A11 Sodium phenylbutyrate 4492.1 -1.3 4-A2 Tranylcypromine 4380.4 -1.3 4-A3 Piroxicam 6018.6 1.0 4-A4 Deprenyl HCl r (-) 6180.0 1.0 4-A5 Troleandomycin 6788.1 1.2 4-A6 Carbidopa 5398.1 -1.1 4-A7 Nimesulide 6248.2 1.1 4-A8 Ketoprofen 5516.0 -1.1 4-A9 Meloxicam 4814.7 -1.2 4-B10 Retinoic acid 5292.6 -1.1 4-B11 Troglitazone 4361.7 -1.4 4-B2 Ergothioneine 5422.9 -1.1 4-B3 Ambroxol 5844.9 -1.0 4-B4 Idebenone 6527.5 1.1 4-B5 Mevastatin 5602.9 -1.1 4-B6 Simvastatin 2456.6 -2.4 4-B7 Suramin sodium 2438.0 -2.4 4-B8 Goserelin acetate 5720.8 -1.0 4-B9 Guaiacol 4994.7 -1.2 4-C10 Delavirdine mesylate 1556.8 -3.8 4-C11 10-hydroxycamptothecin 4771.3 -1.2 4-C2 Bezafibrate 4641.0 -1.3 4-C3 Raloxifene HCl 5789.0 -1.0 4-C4 Camptothecin 3449.5 -1.7 4-C5 Plicamycin 1494.7 -3.9 4-C6 Rifampicin 2326.3 -2.5 4-C7 Etoposide 5280.2 -1.1 4-C8 Mitomycin c 4299.7 -1.4 4-C9 Puromycin 2HCl 2673.8 -2.2 4-D10 Rofecoxib 4864.4 -1.2 4-D11 Ergotamine D-tartrate 3809.4 -1.5 4-D2 Daunorubicin HCl 4932.7 -1.2 4-D3 Doxorubicin HCl 3064.8 -1.9 4-D4 Tanshinone iia 2816.5 -2.1 4-D5 Lapatinib 5038.2 -1.2 4-D6 Methyl salicylate 1798.8 -3.3 4-D7 Pioglitazone 4957.5 -1.2 4-D8 5522.2 -1.1 4-D9 Rivastigmine 4324.5 -1.4 4-E10 Fentiazac 4361.7 -1.4 4-E11 Mephenytoin 4343.1 -1.4 4-E2 Sulindac 4572.7 -1.3 4-E3 Valproic acid 4758.9 -1.2 4-E4 Calcipotriene 5267.8 -1.1 4-E5 5751.8 -1.0 4-E6 3890.1 -1.5 4-E7 Pentamidine 5137.4 -1.1 4-E8 Bortezomib 7855.5 1.3 4-E9 1569.2 -3.8 4-F10 Levetiracetam 2816.5 -2.1 4-F11 Letrozole 3989.4 -1.5 4-F2 Diazoxide 2196.0 -2.7 4-F3 Glyburide 5466.3 -1.1 4-F4 Minoxidil 4821.0 -1.2 4-F5 Tolazamide 5609.1 -1.1 4-F6 Nicorandil 3784.6 -1.6 4-F7 Bexarotene 5205.7 -1.1 4-F8 Bromebric acid 1978.8 -3.0 4-F9 Celecoxib 4833.4 -1.2 4-G10 Didanosine 2239.4 -2.6 4-G11 Dolasetron 3983.2 -1.5 4-G2 Abamectin 4814.7 -1.2 4-G3 Alfacalcidol 1829.9 -3.2 4-G4 Anethole-trithione (anetholtrithion) 1705.7 -3.5 4-G5 Anastrozole 5317.4 -1.1 4-G6 Bicalutamide 4045.3 -1.5 4-G7 Clodronate disodium 5267.8 -1.1 4-G8 Clindamycin palmitate 5571.8 -1.1 4-G9 Diclazuril 4628.6 -1.3 4-H10 Anethole, trans- 3952.2 -1.5 4-H11 Atazanavir 3542.6 -1.7 4-H2 Enalaprilat 4938.9 -1.2 4-H3 Fluvastatin Na 5944.2 1.0 4-H4 Fosinopril 2773.1 -2.1 4-H5 Gemcitabine HCl 6279.3 1.1 4-H6 Ginkgolide a 4150.7 -1.4 4-H7 Granisetron 6142.8 1.0 4-H8 Nedaplatin 5658.7 -1.0 4-H9 Oxaliplatin 5162.3 -1.1 5-A10 Iloprost 4088.7 -1.4 5-A11 Lomerizine HCl 340.2 -17.3 5-A2 Mycophenolate mofetil 2996.2 -2.0 5-A3 Etoricoxib 2930.2 -2.0 5-A4 Clofarabine 5887.6 -1.0 5-A5 Cabergoline 3796.7 -1.6 5-A6 Dilazep 4022.8 -1.5 5-A7 Ibandronate 3052.7 -1.9 5-A8 Imipenem 3570.7 -1.7 5-A9 Lomustine 4173.5 -1.4 5-B10 Rifamycin sv 2694.8 -2.2 5-B11 Risedronic acid 2610.0 -2.3 5-B2 Lofexidine 4408.9 -1.3 5-B3 Meropenem 3843.8 -1.5 5-B4 Nifekalant HCl 3985.1 -1.5 5-B5 Octreotide 3297.6 -1.8 5-B6 Oseltamivir 4625.6 -1.3 5-B7 Pamidronic acid 3495.3 -1.7 5-B8 Pramipexole 3438.8 -1.7 5-B9 Triptorelin 3128.0 -1.9 5-C10 Vincristine sulfate 2233.3 -2.6 5-C11 Acemetacin 2449.9 -2.4 5-C2 Rocuronium bromide 4295.9 -1.4 5-C3 Ricobendazole 3721.4 -1.6 5-C4 Sulbactam 3975.7 -1.5 5-C5 Thiamphenicol glycinate 3335.2 -1.8 5-C6 3730.8 -1.6 5-C7 Vinorelbine 2506.4 -2.4 5-C8 Vindesine 2242.7 -2.6 5-C9 5878.2 -1.0 5-D10 Albendazole 2054.3 -2.9 5-D11 Sumatriptan Succinate 2817.2 -2.1 5-D2 Acetylsalicylic acid 3664.9 -1.6 5-D3 Acipimox 3212.8 -1.8 5-D4 Aceclofenac 3862.7 -1.5 5-D5 Acycloguanosine 3702.5 -1.6 5-D6 3'-azido-3'-deoxythymidine 2996.2 -2.0 5-D7 Allopurinol 2459.3 -2.4 5-D8 Alendronate 2393.4 -2.5 5-D9 Altretamine 3335.2 -1.8 5-E10 Atenolol 3241.0 -1.8 5-E11 Atracurium besylate 3118.6 -1.9 5-E2 Amifostine 3118.6 -1.9 5-E3 Dl-aminoglutethimide 2384.0 -2.5 5-E4 4-aminosalicylic acid 2600.6 -2.3 5-E5 5-aminosalicylic acid 2902.0 -2.0 5-E6 Ampicillin trihydrate 3759.1 -1.6 5-E7 Ampiroxicam 2393.4 -2.5 5-E8 Apramycin 2958.5 -2.0 5-E9 Artemisinin 2807.8 -2.1 5-F10 Buspirone HCl 3109.2 -1.9 5-F11 Canrenone 2741.9 -2.1 5-F2 Azaperone 2977.3 -2.0 5-F3 Vinblastine sulfate 1432.7 -4.1 5-F4 Azithromycin 5934.7 1.0 5-F5 Aztreonam 2967.9 -2.0 5-F6 3194.0 -1.8 5-F7 Bifonazole 538.0 -11.0 5-F8 Bisacodyl 3109.2 -1.9 5-F9 Bromhexine HCl 2459.3 -2.4 5-G10 Chlorambucil 3420.0 -1.7 5-G11 Chlorpheniramine maleate 2920.8 -2.0 5-G2 Carbadox 2525.2 -2.3 5-G3 Carboplatin 2770.1 -2.1 5-G4 Carbamazepine 4173.5 -1.4 5-G5 Cefoperazone acid 2252.1 -2.6 5-G6 Cefotaxime acid 2581.8 -2.3 5-G7 Ceftazidime 2016.7 -2.9 5-G8 Chloramphenicol 3401.2 -1.7 5-G9 Chlormadinone acetate 1432.7 -4.1 5-H10 Clopidol 4192.3 -1.4 5-H11 Clopidogrel sulfate 2619.4 -2.2 5-H2 Chloroquine phosphate 2619.4 -2.2 5-H3 Thalidomide 2110.8 -2.8 5-H4 Ciprofloxacin 3194.0 -1.8 5-H5 Citalopram 2713.6 -2.2 5-H6 Clarithromycin 2854.9 -2.1 5-H7 Climbazole 3457.7 -1.7 5-H8 Clinafloxacin HCl 3523.6 -1.7 5-H9 Clomiphene citrate 434.4 -13.6 6-A10 Dacarbazine 3778.1 -1.6 6-A11 Danazol 3206.7 -1.8 6-A2 Clobetasol propionate 4333.7 -1.4 6-A3 Closantel 5468.7 -1.1 6-A4 Corticosterone 5087.7 -1.2 6-A5 Crotamiton 3127.3 -1.9 6-A6 Cyclophosphamide monohydrate 3690.8 -1.6 6-A7 Cyproterone acetate 3762.2 -1.6 6-A8 Cyclocytidine HCl 3492.4 -1.7 6-A9 Cytarabine 3547.9 -1.7 6-B10 Doxazosin mesylate 4706.8 -1.3 6-B11 Doxifluridine 2976.5 -2.0 6-B2 Dehydroepiandrosterone 4690.9 -1.3 6-B3 Desloratadine 2992.4 -2.0 6-B4 Dextromethorphan HBr 2825.7 -2.1 6-B5 Diclofenac, Na 2262.1 -2.6 6-B6 2',3' - dideoxycytidine 3405.1 -1.7 6-B7 Diethylstilbestrol 2436.8 -2.4 6-B8 Diflunisal 3540.0 -1.7 6-B9 Disulfiram 2484.4 -2.4 6-C10 Estriol 3127.3 -1.9 6-C11 Estrone 3555.9 -1.7 6-C2 3889.2 -1.5 6-C3 Doxycycline HCl 3357.5 -1.8 6-C4 Enalapril 3659.1 -1.6 6-C5 Enoxacin 2920.9 -2.0 6-C6 Enrofloxacin 3309.8 -1.8 6-C7 Ethisterone 4389.3 -1.3 6-C8 potassium 3270.2 -1.8 6-C9 Estradiol 2992.4 -2.0 6-D10 Fenofibrate 2174.8 -2.7 6-D11 Finasteride 4897.2 -1.2 6-D2 Etidronate 2Na 4095.6 -1.4 6-D3 Etretinate 4357.5 -1.4 6-D4 Trichloromethiazide 3262.2 -1.8 6-D5 Famciclovir 3206.7 -1.8 6-D6 Fenbendazole 2119.3 -2.8 6-D7 Fenbufen 4135.3 -1.4 6-D8 Fenoldopam mesylate 3381.3 -1.7 6-D9 Fenoprofen 3460.6 -1.7 6-E10 Fluconazole 2841.6 -2.1 6-E11 Formestane 3468.6 -1.7 6-E2 5-fluorouracil 2643.1 -2.2 6-E3 Flurbiprofen 2849.5 -2.1 6-E4 Fleroxacin 2635.2 -2.2 6-E5 Florfenicol 4103.5 -1.4 6-E6 Floxuridine 3135.2 -1.9 6-E7 Fluocinolone acetonide 3190.8 -1.8 6-E8 Flubendazole 3452.7 -1.7 6-E9 Flutamide 2984.4 -2.0 6-F10 Guaifenesin 3079.7 -1.9 6-F11 Hexestrol 3571.8 -1.6 6-F2 Ftorafur 3667.0 -1.6 6-F3 Furosemide 2690.7 -2.2 6-F4 Ganciclovir 2341.5 -2.5 6-F5 Gatifloxacin 2690.7 -2.2 6-F6 Gentamycin sulfate 2849.5 -2.1 6-F7 Gemfibrozil 3286.0 -1.8 6-F8 Gliclazide 3119.3 -1.9 6-F9 Glimepiride 2762.2 -2.1 6-G10 Itraconazole 3095.5 -1.9 6-G11 Ketoprofen (s) 3301.9 -1.8 6-G2 Hydrocortisone 3119.3 -1.9 6-G3 Hydrocortisone 21-acetate 3079.7 -1.9 6-G4 17- hydroxyprogesterone 904.9 -6.5 6-G5 Idoxuridine 3508.3 -1.7 6-G6 Ifosfamide 2714.6 -2.2 6-G7 Imiquimod 3841.6 -1.5 6-G8 Indapamide 2738.4 -2.2 6-G9 Itopride HCl 2897.1 -2.0 6-H10 3635.3 -1.6 6-H11 Losartan potassium 3579.7 -1.6 6-H2 Levamisole HCl 4167.0 -1.4 6-H3 Levonorgestrel 3714.6 -1.6 6-H4 Levodopa 2674.9 -2.2 6-H5 Levofloxacin HCl 3119.3 -1.9 6-H6 Leflunomide 3317.8 -1.8 6-H7 Lisinopril 3944.8 -1.5 6-H8 Lomefloxacin HCl 3468.6 -1.7 6-H9 Loratadine 2492.3 -2.4 7-A10 Metronidazole 4578.0 -1.3 7-A11 Miconazole 1651.9 -3.6 7-A2 Mebendazol 5360.0 -1.1 7-A3 Medroxyprogesterone 17-acetate 6411.8 1.1 7-A4 Mefenamic acid 5292.6 -1.1 7-A5 Melphalan 5022.9 -1.2 7-A6 Methyldopa 4847.6 -1.2 7-A7 Methylprednisolone 5939.8 1.0 7-A8 Metoprolol tartrate 4699.3 -1.3 7-A9 Methimazole 4854.4 -1.2 7-B10 Niflumic acid 5602.7 -1.1 7-B11 Norethindrone 5676.9 -1.0 7-B2 Minocycline HCl 6148.8 1.0 7-B3 Mitoxantrone 2HCl 2353.1 -2.5 7-B4 Taxol 4422.9 -1.3 7-B5 Myclobutanil 3910.5 -1.5 7-B6 Nadifloxacin 4018.4 -1.5 7-B7 Nabumetone 4099.3 -1.4 7-B8 Naphazoline HCl 4780.2 -1.2 7-B9 Nefazodone 4227.4 -1.4 7-C10 Oxfendazole 4173.4 -1.4 7-C11 Oxibendazole 3249.8 -1.8 7-C2 Norfloxacin 4497.0 -1.3 7-C3 Nystatin 4416.1 -1.3 7-C4 Ofloxacin 4443.1 -1.3 7-C5 Oltipraz 5184.7 -1.1 7-C6 4813.9 -1.2 7-C7 Oxcarbazepine 4483.6 -1.3 7-C8 Oxiconazole nitrate 1672.2 -3.5 7-C9 Oxacillin sodium monohydrate 4153.2 -1.4 7-D10 Piperacillin 5353.3 -1.1 7-D11 Pravastatin lactone 5730.8 -1.0 7-D2 6108.4 1.0 7-D3 Paroxetine HCl 6081.4 1.0 7-D4 Pazufloxacin 4578.0 -1.3 7-D5 Pefloxacine mesylate 3580.1 -1.6 7-D6 Penciclovir 4045.3 -1.5 7-D7 3944.2 -1.5 7-D8 Pencillin v potassium 5569.0 -1.1 7-D9 Phenylbutazone 3741.9 -1.6 7-E10 Praziquantel 3586.9 -1.6 7-E11 Pyrantel pamoate 4551.0 -1.3 7-E2 Pranoprofen 4921.8 -1.2 7-E3 Prednisolone 3418.3 -1.7 7-E4 Progesterone 3512.7 -1.7 7-E5 Procarbazine HCl 4031.9 -1.5 7-E6 Prothionamide 3748.7 -1.6 7-E7 Prednisone 3998.1 -1.5 7-E8 Pregnenolone 4969.0 -1.2 7-E9 Primaquine phosphate 4072.3 -1.4 7-F10 Rimantadine HCl 3512.7 -1.7 7-F11 Propranolol 7227.6 1.2 7-F2 Quinacrine 2HCl dihydrate 1955.3 -3.0 7-F3 Quinapril HCl 3944.2 -1.5 7-F4 Racecadotril 4099.3 -1.4 7-F5 Ranolazine 2HCl 4106.0 -1.4 7-F6 Ramipril 3802.6 -1.5 7-F7 4186.9 -1.4 7-F8 Ribavirin 3371.1 -1.7 7-F9 Nelfinavir Mesylate 815.9 -7.2 7-G10 Sparfloxacin 3202.6 -1.8 7-G11 Spironolactone 6944.4 1.2 7-G2 HCl 5387.0 -1.1 7-G3 Roxithromycin 4813.9 -1.2 7-G4 Rufloxacin 3640.8 -1.6 7-G5 Sarafloxacin HCl 3458.8 -1.7 7-G6 Scopolamine n-butylbromide 3795.9 -1.6 7-G7 Scopolamine HBr 4011.6 -1.5 7-G8 Secnidazole 4342.0 -1.4 7-G9 Sibutramine HCl 3330.7 -1.8 7-H10 Tenoxicam 3371.1 -1.7 7-H11 Terazosin HCl 4834.2 -1.2 7-H2 Stanozolol 6701.7 1.1 7-H3 Streptomycin sulfate 5481.4 -1.1 7-H4 Sulfadoxine 3897.0 -1.5 7-H5 Sulfadiazine 4133.0 -1.4 7-H6 Sulfadimethoxine 4355.5 -1.4 7-H7 Sulfasalazine 4362.2 -1.4 7-H8 Tamsulosin HCl 4058.8 -1.5 7-H9 Telmisartan 3350.9 -1.8 8-A10 Topotecan -657.2 9.0 8-A11 Toremifene -657.2 9.0 8-A2 Tetracycline 5149.3 -1.1 8-A3 Tenatoprazole 4188.9 -1.4 8-A4 Temozolomide 3583.1 -1.6 8-A5 Tibolone 3686.5 -1.6 8-A6 Tioconazole 1145.3 -5.1 8-A7 Tinidazole 5393.0 -1.1 8-A8 Tobramycin (free base) 5385.6 -1.1 8-A9 Tosufloxacin 4994.1 -1.2 8-B10 Valaciclovir -657.2 9.0 8-B11 Vecuronium Br -657.2 9.0 8-B2 Tolfenamic acid 4100.2 -1.4 8-B3 Tolmetin Na 3959.9 -1.5 8-B4 Toltrazuril 3826.9 -1.5 8-B5 Tramadol HCl 4026.4 -1.5 8-B6 4078.1 -1.4 8-B7 Trimethoprim 4233.2 -1.4 8-B8 Tropisetron HCl 4735.6 -1.2 8-B9 Tylosin tartrate 4041.1 -1.5 8-C10 Naloxone HCl -657.2 9.0 8-C11 Naloxonazine 2HCl -657.2 9.0 8-C2 Venlafaxine HCl 4883.3 -1.2 8-C3 Vidarabine 4528.7 -1.3 8-C4 Iproniazid 3974.7 -1.5 8-C5 Benzamil 4935.0 -1.2 8-C6 Bupivacaine HCl 4292.3 -1.4 8-C7 Astemizole 1581.1 -3.7 8-C8 Ketotifen fumarate 4683.8 -1.3 8-C9 Levocabastine HCl 4063.3 -1.5 8-D10 Tiotropium Br -657.2 9.0 8-D11 Mesoridazine besylate -657.2 9.0 8-D2 Harmine 2585.8 -2.3 8-D3 Cinanserin 5917.5 1.0 8-D4 Dibenzepine HCl 4905.5 -1.2 8-D5 Dihydroergocristine mesylate 4122.4 -1.4 8-D6 Fluperlapine 5363.5 -1.1 8-D7 Fluoxetine HCl 1854.5 -3.2 8-D8 Ondansetron 4152.0 -1.4 8-D9 Ketanserin tartrate 3272.9 -1.8 8-E10 -657.2 9.0 8-E11 -657.2 9.0 8-E2 Thioridazine HCl 1049.2 -5.6 8-E3 4174.1 -1.4 8-E4 5289.6 -1.1 8-E5 Isobutylmethylxanthine 4425.3 -1.3 8-E6 maleate 4240.6 -1.4 8-E7 4964.6 -1.2 8-E8 4011.6 -1.5 8-E9 3767.8 -1.6 8-F10 Conduritol b epoxide -657.2 9.0 8-F11 Mifepristone -657.2 9.0 8-F2 4484.4 -1.3 8-F3 3900.8 -1.5 8-F4 Alprostadil 5289.6 -1.1 8-F5 5732.9 -1.0 8-F6 Argatroban 4011.6 -1.5 8-F7 Cilastatin 3708.7 -1.6 8-F8 Artesunate 2814.8 -2.1 8-F9 Picotamide 4491.8 -1.3 8-G10 Miglustat -657.2 9.0 8-G11 Fulvestrant -657.2 9.0 8-G2 Megestrol acetate 4248.0 -1.4 8-G3 Melengestrol acetate 3612.7 -1.6 8-G4 Tamoxifen citrate 1182.2 -5.0 8-G5 Amprenavir 3959.9 -1.5 8-G6 Aprepitant 1248.7 -4.7 8-G7 Bosentan 3524.0 -1.7 8-G8 Efavirenz 1544.2 -3.8 8-G9 Taurocholic acid, sodium salt hydrate 4794.7 -1.2 8-H10 Cyproheptadine -657.2 9.0 8-H11 Benzydamine -657.2 9.0 8-H2 Methysergide 6279.5 1.1 8-H3 Esmolol 5215.7 -1.1 8-H4 Pantothenic acid 6050.5 1.0 8-H5 Phloridzin 5023.7 -1.2 8-H6 Phenylpropanolamine 5326.6 -1.1 8-H7 Succinylcholine 4632.1 -1.3 8-H8 Trifluperidol 2HCl 5511.2 -1.1 8-H9 L-thyroxine [(3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-l-alanine] 6501.1 1.1