WHO/EDM/QSM/2004.6
International Nonproprietary Names (INN) for pharmaceutical substances
Names for radicals & groups comprehensive list
2004
Programme on International Nonproprietary Names (INN) Quality Assurance and Safety: Medicines Essential Drugs and Medicines Policy World Health Organization Geneva
WHO/EDM/QSM/2004.6
WORLD HEALTH ORGANIZATION ORGANISATION MONDIALE DE LA SANTE
International Nonproprietary Names (INN) for pharmaceutical substances
Names for radicals & groups comprehensive list
2004
Programme on International Nonproprietary Names (INN) Quality Assurance and Safety: Medicines Essential Drugs and Medicines Policy World Health Organization Geneva International Nonproprietary Names (INN) for pharmaceutical substances. Names for radicals and groups : comprehensive list
THE ORIGINAL AND SUBSEQUENT EDITION OF THIS DOCUMENT HAD THE REFERENCE NUMBER WHO/PHARM S/NOM 1506
© World Health Organization 2004
All rights reserved. Publications of the World Health Organization can be obtained from Marketing and Dissemination, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (tel: +41 22 791 2476; fax: +41 22 791 4857; email: [email protected]). Requests for permission to reproduce or translate WHO publications – whether for sale or for noncommercial distribution – should be addressed to Marketing and Dissemination, at the above address (fax: +41 22 791 4806; email: [email protected]).
The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may not yet be full agreement.
The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.
All reasonable precautions have been taken by WHO to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either express or implied. The responsibility for the interpretation and use of the material lies with the reader. In no event shall the World Health Organization be liable for damages arising from its use.
Printed by the WHO Document Production Services, Geneva, Switzerland
INN – Names for radicals & groups i
TABLE OF CONTENTS
Pages
- Preface iii
- Reference to the volumes of the WHO Drug Information in v which the respective proposed lists of INNs have been published
- Layout of information vii
- Alphabetical list of names for radicals and groups 1-37
- ANNEX: Groups and elements that have been published 38 together with INNs
ii INN – Names for radicals & groups
Acknowledgements The INN Secretariat wishes to express its gratitude to Dr R. Boudet-Dalbin, France, and to Professor H. Favre, Canada, for their assistance in the preparation of this document. A special thank goes to Mrs E. Cortés, Spain, for review and correction of the Spanish chemical definitions. INN – Names for radicals & groups iii
Preface WHO’S INN PROGRAMME WHO has a constitutional responsibility to "develop, establish and promote international standards with respect to biological, pharmaceutical and similar products". This is the basis for many activities within WHO, such as International Nonproprietary Names (INN), WHO Good Manufacturing Practices, the International Pharmacopoeia, the WHO Certification Scheme and many others. The section of the WHO specifically dealing with selection of International Nonproprietary Names for pharmaceutical substances falls under the Department of Essential Drugs and Medicines Policy. The INN system as it exists today was initiated in 1950 by the World Health Assembly resolution WHA3.11 and began operating in 1953, when the first list of Nonproprietary Names for pharmaceutical substances was published. So far, some 8000 names have been designated as INNs, and this number is growing every year by some 120 – 150 new INNs. INNs are selected in close collaboration with national nomenclature commissions (e.g. BAN British Approved Name, DCF Dénomination Commune Française, DCIt Denominazione Comune Italiana, JAN Japanese Accepted Name, USAN United States Adopted Name etc.). Today, the INN Committee assumes the leading role in assigning generic names to drug substances. Instances where a national generic name for a new pharmaceutical substance is different from the INN are rare exceptions.
INN SELECTION PROCEDURE AND CRITERIA A request for an INN is usually submitted on a form to the World Health Organization. In certain countries, where national nomenclature commissions exist, this is done through the corresponding national nomenclature authority. Precise information on the chemistry, pharmacological action and use, as well as suggested nonproprietary names, name and address of the manufacturer are to be provided on the form. Each name proposed by the originator of such a request is then examined and a name selected. All members of the WHO Expert Panel on the International Pharmacopoeia and Pharmaceutical Preparations designated to select nonproprietary names have to agree to the name which is then first published as a proposed INN. During a four-month period, any person can forward comments, or lodge a formal objection to a name, e.g. on grounds of similarity with a trade-name. If no objection is raised the name will be published a second time as recommended INN. The primary principles for selection are that an INN should be - distinctive in sound and spelling, - not too long, - not liable to confusion with other names in common use.
INNs for substances belonging to a particular group of pharmacologically related substances show their relationship by the use of common stems, which are listed and defined in this document. In addition to the above rules, certain rules have been established to allow the use of INNs internationally, i.e. in various languages. For example, the letters "h” and "k" should be avoided; "e" should be used instead of "ae" and "oe", "i" instead of "y" and "t", "f" instead of "th" and "ph".
Further information on the selection procedure and general principles in devising INNs may be found in the “Guidelines on the Use of International Nonproprietary Names (INNs) for Pharmaceutical Substances” (WHO/PHARM S/NOM 1570). iv INN – Names for radicals & groups
INN – Names for radicals & groups v
Reference to the volumes of the WHO Drug Information in which the respective proposed lists of INNs have been published:
List no. and reference List no. and reference
1 Chron. Wld Hlth Org. 7: 299 (1953) 46 WHO chronicle 35: No. 5, suppl. (1981) 2 Chron. Wld Hlth Org. 8: 216 (1954) 47 WHO chronicle 36: No. 2, suppl. (1982) 3 Chron. Wld Hlth Org. 8: 313 (1954) 48 WHO chronicle 36: No. 5, suppl. (1982) 4 Chron. Wld Hlth Org 10: 28 (1956) 49 WHO chronicle 37: No. 2, suppl. (1983) 5 Chron. Wld Hlth Org. 11: 231 (1957) 50 WHO chronicle 37: No. 5, suppl. (1983) 6 Chron. Wld Hlth Org. 12: 102 (1958) 51 WHO chronicle 38: No. 2 suppl. (1984) 7 WHO chronicle 13: 105 (1959) 52 WHO chronicle 38: No. 4, suppl. (1984) 8 WHO chronicle 13: 152 (1959) 53 WHO chronicle 39: No. 1, suppl. (1985) 9 WHO chronicle 14: 168 (1960) 54 WHO chronicle 39: No. 4, suppl. (1985) 10 WHO chronicle 14: 244 (1960) 55 WHO chronicle 40: No. l, suppl. (1986) 11 WHO chronicle 15: 314 (1961) 56 WHO chronicle 40: No. 5, suppl. (1986) 12 WHO chronicle 16: 385 (1962) 57 WHO drug information 1: No. 2 (1987) 13 WHO chronicle 17: 389 (1963) 58 WHO drug information 1: No. 3 (1987) 14 WHO chronicle 18: 433 (1964) 59 WHO drug information 2: No. 2 (1988) 15 WHO chronicle 19: 446 (1965) 60 WHO drug information 2: No. 4 (1988) 16 WHO chronicle 20: 216 (1966) 61 WHO drug information 3: No. 2 (1989) 17 WHO chronicle 21: 70 (1967) 62 WHO drug information 3: No. 4 (1989) 18 WHO chronicle 21: 478 (1967) 63 WHO drug information 4: No. 2 (1990) 19 WHO chronicle 22: 112 (1968) 64 WHO drug information 4: No. 4 (1990) 20 WHO chronicle 22: 407 (1968) 65 WHO drug information 5: No. 2 (1991) 21 WHO chronicle 23: 183 (1969) 66 WHO drug information 5: No. 4 (1991) 22 WHO chronicle 23: 418 (1969) 67 WHO drug information 6: No. 2 (1992) 23 WHO chronicle 24: 119 (1970) 68 WHO drug information 6: No. 4 (1992) 24 WHO chronicle 24: 413 (1970) 69 WHO drug information 7: No. 2 (1993) 25 WHO chronicle 25: 123 (1971) 70 WHO drug information 7: No. 4 (1993) 26 WHO chronicle 25: 415 (1971) 71 WHO drug information 8: No. 2 (1994) 27 WHO chronicle 26: 121 (1972) 72 WHO drug information 8: No. 4 (1994) 28 WHO chronicle 26: 414 (1972) 73 WHO drug information 9: No. 2 (1995) 29 WHO chronicle 27: 120 (1973) 74 WHO drug information 9: No. 4 (1995) 30 WHO chronicle 27: 380 (1973) 75 WHO drug information 10: No. 2 (1996) 31 WHO chronicle 28: 133 (1974) 76 WHO drug information 10: No. 4 (1996) 32 WHO chronicle 28: No. 9, suppl. (1974) 77 WHO drug information 11: No. 2 (1997) 33 WHO chronicle 29: No. 3, suppl. (1975) 78 WHO drug information 11: No. 4 (1997) 34 WHO chronicle 29: No. 9, suppl. (1975) 79 WHO drug information 12: No. 2 (1998) 35 WHO chronicle 30: No. 3, suppl. (1976) 80 WHO drug information 12: No. 4 (1998) 36 WHO chronicle 30: No. 9, suppl. (1976) 81 WHO drug information 13: No. 2 (1999) 37 WHO chronicle 3l: No. 3, suppl. (1977) 82 WHO drug information 13: No. 4 (1999) 38 WHO chronicle 31: No. 9, suppl. (1977) 83 WHO drug information 14: No. 2 (2000) 39 WHO chronicle 32: No. 3, suppl. (1978) 84 WHO drug information 14: No. 4 (2000) 40 WHO chronicle 32: No. 9, suppl. (1978) 85 WHO drug information 15: No. 2 (2001) 41 WHO chronicle 33: No. 3, suppl. (1979) 86 WHO drug information 16: No. 1 (2002) 42 WHO chronicle 33: No. 9, suppl. (1979) 87 WHO drug information 16: No. 2 (2002) 43 WHO chronicle 34: No. 3, suppl. (1980) 88 WHO drug information 17: No. 1 (2003) 44 WHO chronicle 34: No. 9, suppl. (1980) 89 WHO drug information 17: No. 3 (2003) 45 WHO chronicle 35: No. 3, suppl. (1981) 90 WHO drug information 18: No. 1 (2004) vi INN – Names for radicals & groups
INN – Names for radicals & groups vii
Layout of information
Radical/Group Name (Latin)
List of Proposed INN
pivalas (18)
pivalate 2,2-dimethylpropanoate (ester) pivalate 2,2-diméthylpropanoate (ester) pivalato 2,2-dimetylpropanoato (éster)
C5H9O2
BAN USAN
O
H3C O H3CCH3
Chemical name (English, French, Spanish) Molecular Formula
Graphic Formula
National Name(s)
Radical/Group Name (English, French, Spanish)
viii INN – Names for radicals & groups
INN – Names for radicals & groups 1
INNs: Names for radicals and groups
Comprehensive list
Some substances for which a proposed International Nonproprietary Name has been established may be used in the form of salts or esters. The radicals or groups involved may be of complex composition and it is then inconvenient to refer to them in systematic chemical nomenclature. Consequently, shorter nonproprietary names for some radicals and groups have been devised or selected, and they are suggested for use with the proposed nonproprietary names.
The following list contains radicals and groups which have been published either in the section "Names for radicals and groups" in lists 1-90 of proposed INNs or as part of a two-word INN in lists 1-90 of proposed and 1-51 of recommended INNs, respectively. Whenever a name appeared in both lists, reference is made to its publication only in the category "radicals and groups". Only one reference is given for groups and radicals published as part of a two-word name.
Other groups and elements which have been published in two-word INNs and which may now be considered as being part of the INNM (modified INN) approach are listed in the ANNEX to this document.
In addition, references to British Approved Name (BAN), Japanese Accepted Name (JAN) and United States Adopted Name (USAN) have been included for the radicals, groups and adducts published or accepted for use by these national nomenclature committees. 2 INN – Names for radicals & groups
Latin name prop./rec. list English name chemical name Dénomination en français molecular formula Denominación en español graphic formula ( ) published as INN
acefuras (dexamethasoni acefuras (57)(27))
acefurate acetate (ester), furan-2-carboxylate (ester) acéfurate acétate (ester), furane-2-carboxylate (ester) acefurato acetato (éster), furano-2-carboxilato (éster)
C7H6O5 USAN O O O O H3CO
aceglumas (deanoli aceglumas (15) (*))
aceglumate rac-hydrogen N-acetylglutamate acéglumate rac-N-méthylhydrogénoglutamate aceglumato rac-N-metilhidrógenoglutamato
C7H10NO5
HO C CO - 2 2 O and enantiomer et énantiomère H N H y enantiómero CH3
aceponas (methylprednisoloni aceponas (52)(25))
aceponate acetate (ester), propanoate (ester) acéponate acétate (ester), propanoate (ester) aceponato acetato (éster), propanoato (éster)
C5H8O4
O O
H3C H3CO O
INN – Names for radicals & groups 3 acetonidum (fluocinoloni acetonidum (11)(05)) acetonide propane-2,2-diylbis(oxy) acétonide propane-2,2-diylbis(oxy) acetónido propano-2,2-diilbis(oxi)
C3H6O2 BAN CH3 O CH3 O
aceturas (22) aceturate N-acetylglycinate acéturate N-acétylglycinate aceturato N-acetilglicinato
C4H6NO3 BAN JAN USAN O
- H3CNCO2 H
acibutas (betamethasoni acibutas (26)(12)) acibutate acetate (ester), 2-methylpropanoate (ester) acibutate acétate (ester), 2-méthylpropanoate (ester) acibutato acetato (éster), 2-metilpropanoato (éster)
C6H10O4
O O H3C O H3CO CH3
acistras (64) acistrate acetate (ester), octadecanoate (ester) acistrate acétate (ester), octadécanoate (ester) acistrato acetato (éster), octadecanoato (éster)
C20H38O4 JAN USAN O - CO2 H3CO H3C
4 INN – Names for radicals & groups acoxilum (67) acoxil (acetyloxy)methyl acoxil (acétyloxy)méthyle acoxilo (acetiloxi)metilo
C3H5O2 JAN H3CO CH2 O
alfosceras (cholini alfosceras (60)(29)) alfoscerate (2R)-2,3-dihydroxypropyl hydrogen phosphate alfoscérate hydrogénophosphate de (2R)-2,3-dihydroxypropyle alfoscerato hidrógenofosfato de (2R)-2,3-dihidroxipropilo
C3H8O6P
H OH HO O O P OH O
alideximerum (exatecanum alideximerum (89)(51)) alideximer poly([oxy(2-hydroxyethane-1,1-diyl)]{oxy[1-(hydroxymethyl)ethane- 1,2-diyl]}) partly O-etherified with carboxymethyl groups with some carboxy groups amide linked to the tetrapeptide residue (glygylglycyl- L-phenylalanylglycyl) alideximer poly([oxy(2-hydroxyéthane-1,1-diyl)]{oxy[1-(hydroxyméthyl)éthane- 1,2-diyl]}) partiellement O-éthérifié avec le groupe carboxyméthyle avec quelques groupes carboxamides liés au tétrapeptide (glygylglycyl-L-phénylalanylglycyl) alidexímero poli([oxi(2-hidroxietano-1,1-diil)]{oxi[1-(hidroximetil)etano-1,2-diil]}) en parte O-eterificado con grupos carboximetil de los cuales algunos formen unizes carboxamida con la cadena tetrapeptídica (glicilglicil- L-fenilalanilglicil)
[(C5H10O4)x.(C7H12O6)y.(C22H30N4O9)z]n
OO
R =-H O O -CH2-CO2H R R n or / ou / o :
CH2 Gly Gly Phe Gly O
INN – Names for radicals & groups 5 amsonas (18) amsonate 2,2'-ethene-1,2-diylbis(5-aminobenzene-1-sulfonate) amsonate 2,2'-éthène-1,2-diylbis(5-aminobenzène-1-sulfonate) amsonato 2,2'-eteno-1,2-diilbis(5-aminobenceno-1-sulfonato)
C14H12N2O6S2 BAN JAN
- NH2 SO3
- SO3 H2N
anisatilum (76) anisatil 2-(4-methoxyphenyl)-2-oxoethyl anisatil 2-(4-méthoxyphényl)-2-oxoéthyle anisatilo 2-(4-metoxifenil)-2-oxoetilo
C9H9O2
O
CH2
H3CO
arbamelum (tilnoprofenum arbamelum (74)(36)) arbamel 2-(dimethylamino)-2-oxoethyl arbamel 2-(diméthylamino)-2-oxoéthyle arbamel 2-(dimetilamino)-2-oxoetilo
C4H8NO
O
H3C N CH2 CH3
arginum (insulinum arginum (58)(28))
B B argine 30 α-L-arginine-30 β-L-arginine B B argine 30 α-L-arginine-30 β-L-arginine B B argina 30 α-L-arginina-30 β-L-arginina
C12H25N8O3
-Arg-Arg-OH
6 INN – Names for radicals & groups aritoxum (dorlimomabum aritoxum (66)(32)) aritox ricin A chain-MAB immunotoxine aritox immunotoxine obtenue par couplage du MAB avec la chaîne A de la ricine aritox inmunotoxina obtenida por acoplamiento del anticuerpo monoclonal con la cadena A de la ricina
aspartum (insulinum aspartum (76)(38))
B aspart 28 -L-aspartic acid- B asparte 28 -acide L-aspartique B asparta 28 -ácido-L-aspártico-
C4H5NO3 BAN USAN -Asp-
axetilum (48) axetil rac-1-(acetyloxy)ethyl axétil rac-1-(acétyloxy)éthyle axetilo rac-1-(acetiloxi)etilo
C4H7O2 BAN JAN USAN H3CO and enantiomer C et énantiomère y enantiómero O HCH3
benetonidum (triamcinoloni benetonidum (36)(17)) benetonide N-benzoyl-2-methyl-β-alanine (ester), acetonide bénétonide 3-(benzoylamino)-2-méthylpropanoate (ester),acétonide benetónido 3-(benzoilamino)-2-metilpropanoato (éster), acetónido
C14H18NO5
OO and enantiomer CH3 O NOet énantiomère H y enantiómero CH3 O H CH3
INN – Names for radicals & groups 7
besilas (22)
besilate benzenesulfonate bésilate benzènesulfonate besilato bencenosulfonato
C6H5O3S BAN: besylate JAN USAN: besylate - SO3
bezomilum (62)
bezomil (benzoyloxy)methyl bézomil (benzoyloxy)méthyle bezomilo (benzoiloxi)metilo
C8H7O2 JAN
O CH2 O
buciclas (66)
buciclate trans-4-butylcyclohexanecarboxylate buciclate trans-4-butylcyclohexanecarboxylate buciclato trans-4-butilciclohexanocarboxilato
C11H19O2 JAN - H CO2 H3C H
bunapsilas (24)
bunapsilate 3,7-di-tert-butylnaphthalene-1,5-disulfonate bunapsilate 3,7-di-tert-butylnaphtalène-1,5-disulfonate bunapsilato 3,7-di-terc-butilnaftaleno-1,5-disulfonato
C18H22O6S2 JAN - SO3
(H3C)3C
C(CH3)3 - SO3
8 INN – Names for radicals & groups butepras (61) buteprate butyrate (ester), propionate (ester) butéprate butanoate (ester), propanoate(ester) buteprato butanoato (éster), propanoato (éster)
C7H12O4 JAN USAN O O
H3C H3CO O
camsilas (18) camsilate (7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate camsilate (7,7-diméthyl-2-oxobicyclo[2.2.1]heptan-1-yl)méthanesulfonate camsilato (7,7-dimetil-2-oxobiciclo[2.2.1]heptan-1-il)metanosulfonato
C10H15O4S BAN: camsylate JAN USAN:camsylate - SO3
O H3C H3C
carbesilas (33) carbesilate 4-sulfobenzoate carbésilate 4-sulfobenzoate carbesilato 4-sulfobenzoato
C7H5O5S JAN - CO2
SO3H
INN – Names for radicals & groups 9 ciclotas (28) ciclotate 4-methylbicyclo[2.2.2]oct-2-ene-1-carboxylate ciclotate 4-méthylbicyclo[2.2.2]oct-2-ène-1-carboxylate ciclotato 4-metilbiciclo[2.2.2]oct-2-eno-1-carboxilato
C10H13O2 JAN USAN:cyclotate - CO2
CH3
cilexetilum (73) cilexetil rac-1-{[(cyclohexyloxy)carbonyl]oxy}ethyl cilexétil rac-1-{[(cyclohexyloxy)carbonyl]oxy}]éthyle cilexetilo rac-1-{[(ciclohexiloxi)carbonil]oxi}etilo
C9H15O3 BAN OO and enantiomer C et énantiomère O HCH y enantiómero 3
cipionas (18) cipionate 3-cyclopentylpropanoate cipionate 3-cyclopentylpropanoate cipionato 3-ciclopentilpropanoato
C8H13O2 BAN: cypionate JAN USAN:cypionate - CO2
10 INN – Names for radicals & groups cituxetanum (epitumomabum cituxetanum (89)(51)) cituxetan N-(4-{2(RS)-2-[bis(carboxymethyl)amino)]-3-({2-[bis(carboxymethyl)= amino]ethyl}(carboxymethyl)amino)propyl}phenyl)thiocarbamoyl cituxétan N-(4-{2(RS)-2-[bis(carboxyméthyl)amino)]-3-({2-[bis(carboxyméthyl)= amino]éthyl}(carboxyméthyl)amino)propyl}phényl)thiocarbamoyle cituxetán N-(4-{2(RS)-2-[bis(carboximetil)amino)]-3-({2-[bis(carboximetil)= amino]etil}(carboximetil)amino)propil}fenil)tiocarbamoilo
C22H29N4O10S BAN HO2CCO2H
HO2C N N CO2H * N and epimer at C* H et l'épimère en C* S y el epímero en C* CO2H N H
clofibrolum (acefyllinum clofibrolum (44)(22)) clofibrol 2-(4-chlorophenoxy)-2-methylpropyl clofibrol 2-(4-chlorophénoxy)-2-méthylpropyle clofibrol 2-(4-clorofenoxi)-2-metilpropilo
C10H12ClO
Cl H3C CH3
OCH2
closilas (18) closilate 4-chlorobenzene-1-sulfonate closilate 4-chlorobenzène-1-sulfonate closilato 4-clorobenceno-1-sulfonato
C6H4ClO3S BAN: closylate JAN USAN:closylate - SO3
Cl
INN – Names for radicals & groups 11
crobefas (61)
crobefate rac-{3-[(3E)-4-methoxybenzylidene]-2-(4-methoxyphenyl)chroman- 6-yl phosphate(2-)} crobéfate rac-{phosphate(2-) de 3-[(3E)-4-méthoxybenzylidène]- 2-(4-méthoxyphényl)chroman-6-yle} crobefato rac-{fosfato(2-) de 3-[(3E)-4-metoxibencilideno]- 2-(4-metoxifenil)croman-6-ilo}
C24H19O8P JAN O O - P O - O O and enantiomer H3CO H O et énantiomère y enantiómero
H3CO
cromacas (22)
cromacate 2-[(6-hydroxy-4-methyl-2-oxo-2H-chromen-7yl)oxy]acetate cromacate 2-[(6-hydroxy-4-méthyl-2-oxo-2H-chromén-7-yl)oxy]acétate cromacato 2-[(6-hidroxi-4-metil-2-oxo-2H-cromen-7-il)oxi]acetato
C12H9O6 JAN CH3 OH
- O O OCO2
cromesilas (22)
cromesilate (6,7-dihydroxy-2-oxo-2H-chromen-4-yl)methanesulfonate cromésilate (6,7-dihydroxy-2-oxo-2H-chromén-4-yl)méthanesulfonate cromesilato (6,7-dihidroxi-2-oxo-2H-cromen-4-il)metanosulfonato
C10H7O7S JAN BAN HO O O
HO
- SO3
12 INN – Names for radicals & groups crosfumarilum (hemoglobinum crosfumarilum (76)(38)) crosfumaril (2E)-but-2-enedioyl crosfumaril (2E)-but-2-ènedioyle crosfumarilo (2E)-but-2-enodioilo
C4H4N2O2 USAN CO OC
cyclamas (aminophenazoni cyclamas (16)(*)) cyclamate cyclohexylsulfamate cyclamate cyclohexylsulfamate ciclamato ciclohexilsulfamato
C6H12NO3S
H N - SO3
daloxatum (cefcanelum dolaxatum (59)(29)) daloxate L-alaninate (ester), (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl daloxate L-alaninate (ester), (5-méthyl-2-oxo-1,3-dioxol-4-yl)méthyle daloxato L-alaninato (éster), (5-metil-2-oxo-1,3-dioxol-4-il)metil
C8H11NO5
O O OO H3C O - HNH2 H3CCH2
daropas (74) daropate 3-(dimethylamino)propanoate daropate 3-(diméthylamino)propanoate daropato 3-(dimetilamino)propanoato
C5H10NO2 USAN - H3C CO2 N CH3 INN – Names for radicals & groups 13 deanil (40) deanil 2-(dimethylamino)ethyl déanil 2-(diméthylamino)éthyle déanilo 2-(dimetilamino)etilo
C4H10N JAN H3C NCH2 CH3
decil (40) decil decyl décil décyle decilo decilo
C10H21 JAN H3C CH2
defalanum (## insulinum defalanum (37)(*))
B defalan des-1 -L-phenylalanine-insulin B défalan dés-1 -L-phénylalanine-insuline B defalan des-1 -L-(fenilalanina)-insulina
detemirum (insulinum detemirum (80)(42)) detemir tetradecanoyl détémir tétradécanoyle detemir tetradecanoil
C14H30O BAN USAN O
CH3 dibudinas (25) dibudinate 2,6-di-tert-butylnaphthalene-1,5-disulfonate dibudinate 2,6-bis(1,1-diméthyléthyl)naphtalène-1,5-disulfonate dibudinato 2,6-di-terc-butilnaftaleno-1,5-disulfonato
C18H22O6S2 JAN - SO3
C(CH3)3
(H3C)3C - SO3 14 INN – Names for radicals & groups
dibunas (48)
dibunate 2,6-di-tert-butylnaphthalene-1-sulfonate dibunate 2,6-di-tert-butylnaphtalène-1-sulfonate dibunato 2,6-di-terc-butilnaftaleno-1-sulfonato
C18H23O3S JAN - SO3
C(CH3)3
(H3C)3C
dicibas (locicortoloni dicibas (60)(29))
dicibate dicyclohexylmethyl carbonate dicibate carbonate de dicyclohexylméthyle dicibato carbonato de diciclohexilmetilo
C14H23O3
O
OO
diftitoxum (denileukinum diftitoxum (78)(40))
diftitox N-L-methionyl-387-L-histidine-388-L-alanine-1-388-toxin (Corynebacterium diphtheriae strain C7) (388→2')-protein diftitox N-L-méthionyl[387-L-histidine-388-L-alanine]-(1-388)-toxine (souche C7 de Corynebacterium diphtheriae)-(388→2’) diftitox N-L-metionil-387-L-histidina-388-L-alanina-1-388-toxina (cepa C7 de Corynebacterium diphtheriae) (388→2') USAN
digolilum (59)
digolil 2-(2-hydroxyethoxy)ethyl digolil 2-(2-hydroxyéthoxy)éthyle digolilo 2-(2-hidroxietoxi)etilo
C4H9O2 JAN HO OCH2
INN – Names for radicals & groups 15 diolaminum (22) diolamine 2,2’-azanediyldiethanol diolamine 2,2'-azanediyldiéthanol diolamina 2,2'-azanodiildietanol
C4H11NO2 JAN USAN HO OH N H
docosilum (63) docosil docosyl docosil docosyle docosilo docosilo
C22H45 JAN H3C CH2
dofosfatum (65) dofosfate octadecyl hydrogen phosphate dofosfate hydrogénophosphate d’octadécyle dofostato hidrógenofosfato de octadecilo
C18H38O4P JAN O- H3C O P OH O
ecamas (asoprisnili ecamas (89)(50)) ecamate N-ethylcarbamate écamate N-éthylcarbamate ecamato N-etilcarbamato
C3H6NO2
H H3C N O
O
16 INN – Names for radicals & groups edaminum (70) edamine ethane-1,2-diamine édamine éthane-1,2-diamine edamina etano-1,2-diamina
C2H8N2 USAN NH2 H2N edisilas (18) edisilate ethane-1,2-disulfonate édisilate éthane-1,2-disulfonate edisilato etano-1,2-disulfonato
C2H4O6S2 BAN JAN USAN: edisylate - - SO3 O3S
embonas (18) embonate 4,4'-methylenebis(3-hydroxynaphthalene-2-carboxylate) embonate 4,4'-méthylènebis(3-hydroxynaphtalène-2-carboxylate) embonato 4,4'-metilenbis(3-hidroxinaftaleno-2-carboxilato)
C23H14O6 BAN JAN USAN:pamoate - CO2 OH
CO2- OH
enantas (18) enantate heptanoate énantate heptanoate enantato heptanoato
C7H13O2 BAN: enanthate JAN USAN:enanthate H CCO- 3 2
INN – Names for radicals & groups 17 enbutas (icometasoni enbutas (70)(34)) enbutate acetate (ester), butanoate (ester) enbutate acétate (ester), butanoate (ester) enbutato acetato (éster), butanoato (éster)
C6H10O4 BAN O O
H3CO H3CO epolaminum (69) epolamine 2-(pyrrolidin-1-yl)ethanol épolamine 2-(pyrrolidin-1-yl)éthanol epolamina 2-(pirrolidin-1-il)etanol
C6H13NO USAN OH N
erbuminum (62) erbumine 2-methylpropan-2-amine erbumine 2-méthylpropan-2-amine erbumina 2-metilpropan-2-amina
C4H11N BAN JAN USAN H3CCH3 H3CNH2
esilas (18) esilate ethanesulfonate ésilate éthanesulfonate esilato etanosulfonato
C2H5O3S BAN: esylate JAN USAN:esylate H CSO- 3 3
18 INN – Names for radicals & groups estolas (28) estolate propanoate (ester), dodecyl sulfate (salt) estolate propanoate (ester), sulfate de dodécyle (sel) estolato propanoate (éster), sulfato de dodecilo (sal)
C15H30O6S JAN USAN O - SO3 H3C H CO O 3
etabonas (64) etabonate ethyl carbonate étabonate carbonate d’éthyle etabonato carbonato de etilo
C3H5O3 JAN USAN - H3C O O
O
etilsulfas (mecetronii etilsulfas (51)(24)) etilsulfate ethyl sulfate étilsulfate sulfate d’éthyle etilsulfato sulfato de etilo
C2H5O4S BAN USAN ethylsulfate - SO3 H3CO
farnesilum (61) farnesil (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl farnésil (2E,6E)-3,7,11-triméthyldodéca-2,6,10-trién-1-yle farnesilo (2E,6E)-3,7,11-trimetildodeca-2,6,10-trien-1-il
C15H25 JAN H3C CH2 CH3 CH3 CH3
INN – Names for radicals & groups 19 fendizoas (64) fendizoate 2-(6-hydroxybiphenyl-3-carbonyl)benzoate fendizoate 2-(6-hydroxybiphényl-3-carbonyl)benzoate fendizoato 2-(6-hidroxibifenil-3-carbonil)benzoato
C20H13O4 JAN - CO2
O
OH
fostedatum (70) fostedate tetradecyl hydrogen phosphate fostédate hydrogénophosphate de tétradécyle fostedato hidrógenofosfato de tetradecilo
C14H30O4P USAN O- H3CO P OH O
furetonidum (triamcinoloni furetonidum (36)(17)) furetonide 1-benzofurane-2-carboxylate (ester), propane-2,2-diylbis(oxy) furétonide 1-benzofurane-2-carboxylate (ester), propane-2,2-diylbis(oxy) furetónido 1-benzofurano-2-carboxilato (éster), propano-2,2-diilbis(oxi)
C12H11O5
O O CH3 O O CH3 O
gamolenatum (ascorbylum gamolenatum (79)(41)) gamolenate (6Z,9Z,12Z)-octadeca-6,9,12-trienoate gamolénate (6Z,9Z,12Z)-octadéca-6,9,12-triénoate gamolenato (6Z,9Z,12Z)- octadeca-6,9,12-trienoato
C18H29O2 BAN O
H3C O
20 INN – Names for radicals & groups glarginum (insulinum glarginum (76)(38))
A B B glargine 21 -glycine-30 α-L-arginine-30 β-L-arginine A B B glargine [21 -glycine]30 α-L-arginine-30 β-L-arginine A B B glargina 21 -glicina-30 α-L-arginina-30 β-L-arginina
C14H28N9O4 BAN USAN Gly- -Arg-Arg
gluceptas (18) gluceptate D-glycero-D-gulo-heptonate gluceptate D-glycéro-D-gulo-heptonate gluceptato D-glicero-D-gulo-heptonato
C7H13O8 BAN JAN USAN H HOHHH - HOH2C CCCCCCO2 OH OHH OH OH
glulisinum (insulinum glulisinum (84)(46))
B B glulisine [3 -L-lysine,29 -L-glutamic acid] B B glulisine [3 -L-lysine,29 -L-acide glutamique] B B glulisina [3 -L-lisina,29 -L-ácido glutámico]
USAN -Lys- -Glu-
glutamerum (hemoglobinum glutamerum (80)(42)) glutamer glutaraldehyde polymer glutamère polymère de glutaraldéhyde glutámero polímero de glutaraldehido
C5H7O2
O CHO
INN – Names for radicals & groups 21 guacilum (amtolmetinum guacilum (65)(32)) guacil 2-methoxyphenyl guacil 2-méthoxyphényle guacilo 2-metoxifenilo
C7H7O
OCH3
hexacetonidum (triamcinoloni hexacetonidum (15)(06)) hexacetonide 3,3-dimethylbutanoate (ester), propan-2,2-diylbis(oxy) hexacétonide 3,3-diméthylbutanoate (ester), propan-2,2-diylbis(oxy) hexacetónido 3,3-dimetilbutanoato (éster), propan-2,2-diilbis(oxi)
C9H17O4
BAN USAN H C CH O 3 3 CH3 O CH O H3CO3
hibenzas (18) hibenzate 4-(4-hydroxybenzoyl)benzoate hibenzate 4-(4-hydroxybenzoyl)benzoate hibenzato 4-(4-hidroxibenzoil)benzoato
C14H9O4 JAN USAN:hybenzate
- HO CO2
O
hyclas (62) hyclate ethanol – hydrogen chloride - water (½ / 1 / ½) hyclate éthanol – chlorure d’hydrogène – eau (½ / 1 / ½) hiclato etanol – cloruro de hidrógeno – agua (½ / 1 / ½)
½ (C2H5OH⋅2HCl⋅ H2O) JAN USAN 22 INN – Names for radicals & groups hydroxynaphthoas (bephinii hydroxynaphtoas (11) (05)) hydroxynaphtoate 3-hydroxynaphthalene-2-carboxylate hydroxynaphtoate 3-hydroxynaphtalène-2-carboxylate hidroxinaftoato 3-hidroxinaftaleno-2-carboxilato
C11H7O3 BAN - CO2
OH
isetionas (18) isetionate 2-hydroxyethane-1-sulfonate isétionate 2-hydroxyéthane-1-sulfonate isetionato 2-hidroxietano-1-sulfonato
C2H5O4S BAN:isethionate JAN USAN:isethionate - SO3 HO
lauril (41) lauril dodecyl lauril dodécyle laurilo dodecilo
C12H25 JAN H3C CH2
laurilsulfas (24) laurilsulfate dodecyl sulfate laurilsulfate sulfate de dodécyle laurilsulfato sulfato de dodecilo
C12H25O4S JAN - SO3 H3CO
INN – Names for radicals & groups 23 lisetilum (cromoglicas lisetilum (72)(35)) lisetil L-lysinate (ester), diethyl (ester) lisétil L-lysinate (ester), diéthyl (ester) lisetilo L-lisinato (éster), dietilico (éster)
C10H23N2O2
H NH2 O CH 2 2 H2N H3C O
lisicolum (fluoresceinum lisicolum (89)(51)) lisicol {N-[(5S)-5-carboxy-5-(3α,7α,12α-trihydroxy-5β-cholan- 24-amido)pentyl]carbamothioyl}amino lisicol {N-[(5S)-5-carboxy-5-(3α,7α,12α-trihydroxy-5β-cholan- 24-amido)pentyl]carbamothioyl}amino lisicol {N-[(5S)-5-carboxi-5-(3α,7α,12α-trihidroxi-5β-colan- 24-amido)pentil]carbamotioil}amino
C31H52N3O6S
S O N NH H H3C H H HN CO2H HO CH3 H H
CH3 H
H H HO H H H OH
lisprum (insulinum lisprum (72)(35))
B B lispro 28 -L-lysine-29 -L-proline B B lispro [28 -L-lysine-29 -L-proline] B B lispro 28 -L-lisina, 29 -L-prolina BAN USAN -Lys-Pro
mafenatoxum (anatumomabum mafenatoxum (86)(48)) mafenatox enterotoxin A (227-alanine) (Staphylococcus aureus) mafénatox (227-alanine)entérotoxine A (Staphylococcus aureus) mafenatox (227-alanina)enterotoxina A de Staphylococcus aureus
24 INN – Names for radicals & groups
medoxomilum (olmesartanum medoxomilum (86)(48))
medoxomil (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl médoxomil (5-méthyl-2-oxo-1,3-dioxol-4-yl)méthyle medoxomilo 5-(metil-2-oxo-1,3-dioxol-4-il)metilo
C5H5O3 BAN USAN H3C O O C O H2
megallas (33)
megallate 3,4,5-trimethoxybenzoate mégallate 3,4,5-triméthoxybenzoate megallato 3,4,5-trimetoxibenzoato
C10H11O5 BAN JAN - H3CO CO2
H3CO OCH3
merpentanum (technetium (99m Tc) nofetumomabum merpentanum (81)(42)) merpentan {N,N’-[1-(3-oxopropyl)ethane-1,2-diyl]bis(2-sulfanylacetamidato)}(4-) merpentan {N,N’-[1-(3-oxopropyl)éthane-1,2-diyl]bis(2-sulfanylacétamidato)}(4-) merpentan {N,N’-[1-(3-oxopropil)etano-1,2-diil]bis(2-sulfanilacetamidato)}(4-)
C9H11N2O3S2 USAN O
O O NN
SS
INN – Names for radicals & groups 25 mertansinum (cantuzumabum mertansinum (89)(51)) mertansine tetrakis{(4RS)-4[(3-{[(1S)-2-{[(1S,2R,3S,5S,6S,16E,18E,20R,21S)- 11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl- 8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]= hexacosa-10,12,14(26),16,18-pentaen-6-yl]oxy}-1-methyl- 2-oxoethyl]methylamino}-3-oxopropyl)disulfanyl]pentanoyl} mertansine tétrakis{(4RS)-4[(3-{[(1S)-2-{[(1S,2R,3S,5S,6S,16E,18E,20R,21S)- 11-chloro-21-hydroxy-12,20-diméthoxy-2,5,9,16-tétraméthyl- 8,23-dioxo-4,24-dioxa-9,22-diazatétracyclo[19.3.1.110,14.03,5]= hexacosa-10,12,14(26),16,18-pentaén-6-yl]oxy-1-méthyl- 2-oxoéthyl]méthylamino}-3-oxopropyl)disulfanyl]pentanoyle} mertansina tetrakis{(4RS)-4-[[3-[[(1S)-2-[[(1S,2R,3S,5S,6S,16E,18E,20R,21S)- 11-cloro-21-hidroxi-2,5,9,16-tetrametil -12,20-dimetoxi-4,24-dioxa- 8,23-dioxo-9,22-diazatetraciclo[19.3.1.110,14.03,5]hexacosa- 10,12,14(26),16,18-pentaen-6-il]oxi]-1-metil-2-oxoetil]metilamino]- 3-oxopropil]disulfanil]pentanoilo}
(C40H55N3O11S2Cl)4
USAN
O O H CH3 S O S N
CH3 H3C CH3 O CH3 Cl O H H3C N OCH3 H H H O O OH
O N H HOCH 3 CH3
4
mesilas (18) mesilate methanesulfonate mésilate méthanesulfonate mesilato metanosulfonato
CH3O3S BAN: mesylate JAN USAN:mesylate - SO3 H3C
26 INN – Names for radicals & groups
metembonas (26)
metembonate 4,4'-methylenebis(3-methoxynaphthalene-2-carboxylate) métembonate 4.4'-méthylènebis(3-méthoxynaphtalène-2-carboxylate) metembonato 4,4'-metilenobis(3-metoxinaftaleno-2-carboxilato)
C25H18O6 JAN
- CO2
OCH3 OCH3 - O2C
methonitras (atropini methonitras (04)(03))
methonitrate N-methyl, nitrate (salt) méthonitrate N-méthyl, nitrate (sel) metonitrato N-metil, nitrato (sal)
CH3NO3
- CH3 – NO3
metilsulfas (18) metilsulfate methyl sulfate métilsulfate sulfate de méthyle metilsulfato sulfato de metilo
CH3O4S JAN
- H3C SO3 O
metiodidum (buzepidi metiodidum (14)(06))
metiodide N-methyl, iodide (salt) métiodure N-méthyl, iodure (sel) metioduro N-metilo, ioduro (sal)
CH3I
- CH3 – I
INN – Names for radicals & groups 27 mofetilum (65) mofetil 2-(morpholin-4-yl)ethyl mofétil 2-(morpholin-4-yl)éthyle mofetilo 2-(morfolin-4-il)etilo
C6H12NO JAN USAN
NCH2 O
napadisilas (18) napadisilate naphthalene-1,5-disulfonate napadisilate naphtalène-1,5-disulfonate napadisilato naftaleno-1,5-disulfonato
C10H6O6S2 BAN: napadisylate JAN - SO3
- SO3
napsilas (18) napsilate naphthalene-2-sulfonate napsilate naphtalène-2-sulfonate napsilato naftaleno-2-sulfonato
C10H7O3S BAN:napsylate JAN USAN:napsylate
- SO3
octilum (65) octil octyl octil octyle octilo octilo
C8H17 JAN H3C CH2
28 INN – Names for radicals & groups
olaminum (22)
olamine 2-aminoethanol olamine 2-aminoéthanol olamina 2-aminoetanol
C2H7NO JAN USAN OH H2N
oxogluras (22)
oxoglurate hydrogen 2-oxopentanedioate oxoglurate 2-oxohydrogénopentanedioate oxoglurato 2-oxohidrógenopentanodioato
C5H5O5 JAN
- HO2CCO2
O
pegolum (enlimomab pegol (77)(39))
pegol α-(2-carboxyethyl)-ω-methoxypoly(oxyethane-1,2-diyl) pégol α-(2-carboxyéthyl)-ω-méthoxypoly(oxyéthane-1,2-diyl) pegol α-(2-carboxietil)-ω-metoxipoli(oxietano-1,2-diil)
USAN
pamoate -> see embonate
pentexilum (65) pentexil (RS)-1-[(2,2-dimethylpropanoyl)oxy]ethyl pentexil (RS)-1-[(2,2-diméthylpropanoyl)oxy]éthyle pentexilo (RS)-1-[(2,2-dimetilpropanoil)oxi]etilo
C7H13O2
H C CH 3 3 and enantiomer O H C C et énantiomère 3 y enantiómero O HCH3
INN – Names for radicals & groups 29 pivalas (18) pivalate 2,2-dimethylpropanoate (ester) pivalate 2,2-diméthylpropanoate (ester) pivalato 2,2-dimetipropanoato (éster)
C5H9O2 BAN USAN O
H3C O H3CCH3
pivoxetilum (54) pivoxetil rac-1-[(2-methoxy-2-methylpropanoyl)oxy]ethyl pivoxétil rac-1-[(2-méthoxy-2-méthylpropanoyl)oxy]éthyle pivoxetilo rac-1-[(2-metoxi-2-metilpropanoil)oxi]etilo
C7H13O3 BAN JAN USAN H C OCH 3 3 and enantiomer O H C C et énantiomère 3 y enantiómero O HCH3
pivoxil (44) pivoxil [(2,2-dimethylpropanoyl)oxy]methyl pivoxil [(2,2-diméthylpropanoyl)oxy]méthyle pivoxilo [(2,2-dimetilpropanoil)oxi]metilo
C6H11O2 JAN USAN H3C CH3 O H3C CH2 O
30 INN – Names for radicals & groups poliglumexum (paclitaxelum poliglumexum (90)) poliglumex [poly(L-glutamic acid)z―(L-glutamate-γ-ester)―poly (L-glutamic acid)y]n poliglumex [poly[(acide L-glutamique)z―(L-glutamate-γ-ester)―poly(acide L-glutamique)y]n poliglumex [poli[(ácido L-glutámico)z―(L-glutámato-γ-ester)―poli(ácido L-glutámico)y]n
[(C5H7NO3)z.(C5H6NO3).(C5H7NO3)y]n.H2O
HO HO O O
O H H H H N OH N N H H O H O z y
O
O n
proxetilum (58) proxetil rac-1-{[(propan-2-yloxy)carbonyl]oxy}ethyl proxétil rac-1-{[(propan-2-yloxy)carbonyl]oxy}éthyle proxetilo rac-1-{[(propan-2-iloxi)carbonil]oxi}etilo
C6H11O3 BAN JAN USAN H3COO and enantiomer C et énantiomère y enantiómero CH3 O HCH3
INN – Names for radicals & groups 31 raffimerum (hemoglobinum raffimerum (89)(51)) raffimer (2S,4R,6R,8S,11S,13S)-2,4,8,13-tetrakis(hydroxymethyl)- 4,6,11-tris(ylomethyl)-3,5,7,10,12-pentaoxatetradecane-1,14-diyl raffimer (2S,4R,6R,8S,11S,13S)-2,4,8,13-tétrakis(hydroxyméthyl)- 4,6,11-tris(ylométhyl)-3,5,7,10,12-pentaoxatétradécane-1,14-diyle rafímero (2S,4R,6R,8S,11S,13S)-2,4,8,13-tetrakis(hidroximetil)- 4,6,11-tris(ilometil)-3,5,7,10,12-pentaoxatetradecano-1,14-diilo
C16H29O9
OH
HO CH2 O CH2 OO HO OOCH2
H2CCH2 OH
soproxilum (82)
soproxil {[(propan-2-yloxy)carbonyl]oxy}methyl soproxil {[(propan-2-yloxy)carbonyl]oxy}méthyle soproxilo {[(propan-2-iloxi)carbonil]oxi}metilo
C5H9O3
H3COO CH2 CH3 O
steaglas (18) steaglate 2-(octadecanoyloxy)acetate (ester) stéaglate 2-(octadécanoyloxy)acétate (ester) esteaglato 2-(octadecanoiloxi)acetato (éster)
C20H37O4 JAN:steagrate O
H3CO O O
32 INN – Names for radicals & groups stinopras (erythromycini stinopras (58)(27)) stinoprate N-acetylcysteinate (salt), propanoate (ester) stinoprate N-acétylcystéinate (sel), propanoate (ester) estinoprato N-acetilcisteinato (sal), propanoato (éster)
C8H13NO5S
- CO2 HS O O H N H3C H O CH3
succinilum (norfloxacini succinilum (58)(28)) succinil 3-carboxypropanoyl succinil 3-carboxypropanoyle succinilo 3-carboxipropanoilo
C4H5O3
HO2C
O
sudotoxum (alvirceptum sudotoxum (69)(34)) sudotox 248-L-histidine-249-L-methionine-250-L-alanine-251-L-glutamic acid-248-613-exotoxin A (Pseudomonas aeruginosa reduced) sudotox 248-L-histidine-249-L-méthionine-250-L-alanine-251-acide L-glutamique-248-613-exotoxine A (Pseudomonas aeruginosa réduite) sudotox 248-L-histidina-249-L-metionina-250-L-alanina-251-ácido L-glutámico-248-613-exotoxina A (Pseudomonas aeruginosa reducida) USAN
suleptanas (methylprednisoloni suleptanas (56)(27)) suleptanate 8-[methyl(2-sulfoethyl)amino]-8-oxooctanoate (ester), monosodium salt suleptanate 8-[méthyl(2-sulfoéthyl)amino]-8-oxooctanoate (ester), sel monosodique suleptanato 8-[metil(2-sulfoetil)amino]-8-oxooctanoato (éster), sal monosódica
C11H19NNaO6 BAN USAN CH3 O N NaO3S O O INN – Names for radicals & groups 33
sulfoxylas (phenarsoni sulfoxylas (01)(*))
sulfoxylate sulfinomethyl, monosodium salt sulfoxylate sulfinométhyle, sel monosodique sulfoxilato sulfinometilo, sal monosódica
CH2NaO2S
– CH2 –SO2Na
tafenatoxum (nacolomabum tafenatoxum (80)(41))
tafenatox enterotoxin A (Staphyloccus aureus) tafénatox entérotoxine A (Staphyloccus aureus) tafenatox enterotoxina A (Staphyloccus aureus)
tebutas (22) tebutate 3,3-dimethylbutanoate tébutate 3,3-diméthylbutanoate tebutato 3,3-dimetilbutanoato
C6H11O2 JAN USAN H C 3 CH3 - CO2 H3C
tenoas (52)
tenoate thiophene-2-carboxylate ténoate thiophène-2-carboxylate tenoato tiofeno-2-carboxilato
C5H3O2S JAN - S CO2
34 INN – Names for radicals & groups teoclas (18) teoclate 8-chloro-1,3-dimethyl-2,6-dioxo-3,6-dihydro-1H-purin-7-(2H)-ide téoclate 8-chloro-1,3-diméthyl-2,6-dioxo-3,6-dihydro-1H-purin-7-(2H)-ure teoclato 8-cloro-1,3-dimetil-2,6-dioxo-3,6-dihidro-1H-purin-7-(2H)-uro
C7H6ClN4O2 BAN:theoclate JAN O
H3C N- N Cl O N N CH3
teprosilas (29) teprosilate 3-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)propane- 1-sulfonate téprosilate 3-(1,3-diméthyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)propane- 1-sulfonate teprosilato 3-(1,3-dimetil-2,6-dioxo-1,2,3,6-tetrahidro-7H-purin-7-il)propane- 1-sulfonato
C10H13N4O5S JAN O - SO3 H3C N N
O N N CH3
tidoxilum (fozivudinum tidoxilum (73)(36)) tidoxil rac-2-(decyloxy)-3-(dodecylsulfanyl)propyl tidoxil rac-2-(décyloxy)-3-(dodécylsulfanyl)propyle tidoxilo rac-2-(deciloxi)-3-(dodecilsulfanil)propil
C25H51OS
and enantiomer H3C O H et énantiomère H CS 3 y enantiómero CH2 INN – Names for radicals & groups 35
tiuxetanum (ibritumomabum tiuxetanum (86)(48))
tiuxetan N-(4-{(2S)-2-[bis(carboxymethyl)amino]-3-[(2RS)-{2- [bis(carboxymethyl)amino]propyl}(carboxymethyl)amino]propyl}= phenyl) thiocarbamoyl tiuxétan N-(4-{(2S)-2-[bis(carboxyméthyl)amino]-3-[(2RS)-{2- [bis(carboxyméthyl)amino]propyl}(carboxyméthyl)amino]propyl}= phényl]thiocarbamoyle tiuxetán N-(4-{(2S)-2-[bis(carboximetil)amino]-3-[(2RS)-{2-[bis(carboximetil)= amino]propil}(carboximetil)amino]propil}fenil)tiocarbamoilo
C23H31N4O10S BAN USAN CO2HCO2H H HO2C N and epimer at C* CH3 N CS H H et l'épimère en C* N ∗ y el epímero en C* HO2CN
HO2C
tocoferilum (tretinoinum tocoferilum (66)(32))
tocoferil rac-(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12- trimethyltridecyl]chroman-6-yl tocoféril rac-(2R)-2,5,7,8-tetraméthyl-2-[(4R,8R)-4,8,12- triméthyltridécyl]chroman-6-yl tocoferilo rac-(2R)-2,5,7,8-tetrametil-2-[(4R,8R)-4,8,12- trimetiltridecil]croman-6-ilo
C29H49O
CH3 H C OCH 3 3 and enantiomer CH et énantiomère 3 HCH HCH 3 3 CH3 y enantiómero
CH3
tofesilas (27)
tofesilate 3-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)ethane- 1-sulfonate tofésilate 3-(1,3-diméthyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)éthane- 1-sulfonate tofesilato 3-(1,3-dimetil-2,6-dioxo-1,2,3,6-tetrahidro-7H-purin-7-il)etano- 1-sulfonato
C9H11N4O5S JAN O - SO3 H3C N N
O N N CH3 36 INN – Names for radicals & groups tosilas (18) tosilate 4-methylbenzene-1-sulfonate tosilate 4-méthylbenzène-1-sulfonate tosilato 4-metilbenceno-1-sulfonato
C7H7O3S BAN:tosylate JAN USAN:tosylate - SO3
H3C
triclofenas (18) triclofenate 2,4,5-trichlorophenolate triclofénate 2,4,5-trichlorophénolate triclofenato 2,4,5-triclorofenolato
C6H2Cl3O JAN Cl O-
Cl Cl
triflutas (64) triflutate trifluoroacetate triflutate trifluoroacétate triflutato trifluoroacetato
C2F3O2 JAN USAN O
F3CO
trolaminum (22) trolamine 2,2’,2’’-nitrilotriethanol trolamine 2,2',2'’-nitrilotriéthanol trolamina 2,2’,2’’-nitrilotrietanol
C6H15NO3 JAN USAN OH N HO OH
INN – Names for radicals & groups 37 troxundas (46) troxundate [2-(2-ethoxyethoxy)ethoxy]acetate troxundate [2-(2-éthoxyéthoxy)éthoxy]acétate troxundato [2-(2-etoxietoxi)etoxi]acetato
C8H15O5 BAN JAN - H3C O O CO2 O
xinafoas (63) xinafoate 1-hydroxynaphthalene-2-carboxylate xinafoate 1-hydroxynaphtalène-2-carboxylate xinafoato 1-hidroxinaftaleno-2-carboxilato
C11H7O3 BAN JAN USAN OH - CO2
* * * * * * * * *
38 INN – Names for radicals & groups
ANNEX
The following groups and elements have also been published together with INNs:
benzoas benzoate benzoate benzoate benzoate benzoato benzoato
C7H5O2
- CO2
bromidum bromide bromure bromuro
Br -
caproas caproate hexanoate caproate hexanoate caproato hexanoato
C6H11O2
- CO2 H3C
chloridum chloride chlorure cloruro
Cl -
INN – Names for radicals & groups 39 hemissuccinas hemisuccinate hydrogen butanedioate hémisuccinate hydrogénobutanedioate hemisuccinato hidrógenobutanodioato
C4H5O4
- CO2 HO2C
iodidum iodide iodure ioduro
I -
lauras laurate dodecanoate laurate dodécanoate laurato dodecanoato
C12H23O2
- CO2 H3C
methylbromidum methylbromide N-methyl, bromide (salt) méthylbromure N-méthyl, bromure (sel) metilbromuro N-metil, bromuro (sal)
CH3Br
- H3C– Br
nicotinas nicotinate pyridine-3-carboxylate nicotinate pyridine-3-carboxylate nicotinato piridina-3-carboxilato
C6H4NO2
N
- CO2 40 INN – Names for radicals & groups oleas oleate (9Z)-octadec-9-enoate oléate (9Z)-octadéc-9-énoate oleato (9Z)-octadec-9-enoato
C18H33O2
H C CO - 3 2
palmitas palmitate hexadecanoate palmitate hexadécanoate palmitato hexadecanoato
C16H31O2
- CO2 H3C
perchloras perchlorate perchlorate perclorato
- ClO4
potassio(kalii) potassium potassium (de) potasio
K +
salicylas salicylate 2-hydroxybenzoate salicylate 2-hydroxybenzoate salicilato 2-hidroxibenzoato
C7H5O3
- CO2 OH
INN – Names for radicals & groups 41 sesquioleas sesquioleate (9Z)-octadec-9-enoate(1.5) sesquioléate (9Z)-octadéc-9-énoate(1,5) sesquioleato (9Z)-octadec-9-enoato(1.5)
3 /2 · (C18H33O2)
3/2 H CCO- 3 2
sodio(natrii) sodium sodium (de) sodio
Na +
stearas stearate octadecanoate stéarate octadécanoate estearato octadecanoato
C18H35O2
- CO2 H3C
sulfas sulfate sulfate sulfato
- SO4
tartras tartrate (2R,3R)-2,3-dihydroxybutanedioate tartrate (2R,3R)-2,3-dihydroxybutanedioate tartrato (2R,3R)-2,3-dihidroxibutanodioato
C4H4O6
- HO CO2 H OH - O2C H 42 INN – Names for radicals & groups trioleas trioleate (9Z)-octadec-9-enoate(3) or tris[(9Z)-octadec-9-enoate] trioléate (9Z)-octadéc-9-énoate(3) ou tris[(9Z)-octadéc-9-énoate] trioleato (9Z)-octadec-9-enoato(3) o tris[(9Z)-octadec-9-enoato]
. 3 (C18H33O2)
3 H CCO- 3 2
tristearas tristearate octadecanoate(3) or tris(octadecanoate) tristéarate octadécanoate(3) ou tris(octadécanoate) triéstearato octadecanoato(3) o tris(octadecanoato)
. 3 (C18H35O2)
3 H3C - CO2
undecylas undecylate undecanoate undécylate undécanoate undecilato undecanoato
C11H21O2
H C - 3 CO2
undecylenas undecylenate undec-10-enoate undécylénate undéc-10-énoate undecilenato undec-10-enoato
C11H19O2
H2C - CO2
valeras valerate pentanoate valérate pentanoate valerato pentanoato
C5H9O2
H C CO - 3 2
* * * * * * * * *
WHY INNs?
Since the number of drug substances being registered during the last decades is constantly increasing, there is a strong need to ensure the identification of each pharmaceutical compound by a unique, universally available and accepted name. The existence of an international nomenclature system for pharmaceutical products is crucial for the clear identification, safe prescription and dispensing of medicines to patients, and for communication and exchange of information among health professionals and scientists worldwide.
An International Nonproprietary Name (INN) identifies a pharmaceutical substance by a unique name that is globally recognized and is public property. A nonproprietary name is also known as a generic name. Generic names are intended to be used in pharmacopoeias, labeling, advertising, drug regulation and scientific literature.