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A Science State of Mind NEW YORK: A SCIENCE STATE OF MIND A Special Publication of The New York Academy of Sciences Magazine A publication of The New York Academy of Sciences Magazine November 2013 © The New York Academy of Sciences Cover photo credit: Samuel Stuart Photography NEW YORK: A SCIENCE STATE OF MIND EXECUTIVE EDITOR Diana Friedman PRODUCTION EDITOR Jennifer Shin GRAPHIC DESIGNER Demetra Georgiou CONTRIBUTORS W.M. Akers, Steven Barboza, Sharon Begley, Hallie Kapner, Noah Rosenberg PRESIDENT & CEO Ellis Rubinstein VICE PRESIDENT & CHIEF DEVELOPMENT OFFICER Kiryn Haslinger Hoffman ASSOCIATE DIRECTOR, DEVELOPMENT Erica Nofi DIRECTOR, PRINCIPAL GIFTS Katherine Underwood DIRECTOR, CORPORATE RELATIONS Alicia Sanchez DIRECTOR, BUSINESS DEVELOPMENT David Smith EXECUTIVE DIRECTOR, COMMUNICATIONS Diane Fusilli DEVELOPMENT ASSISTANT Azadeh Zeyghami EDITORIAL OFFICE 7 World Trade Center 250 Greenwich St, 40th Floor New York, NY 10007-2157 Phone: 212.298.8645 Email: [email protected] MEMBERSHIP Phone: 212.298.8640 Email: [email protected] Visit the Academy online at www.nyas.org BOARD OF GOVERNORS CHAIR VICE-CHAIR NANCY ZIMPHER PAUL WALKER TREASURER PRESIDENT SECRETARY ROBERT CATELL ELLIS RUBINSTEIN LARRY SMITH GOVERNORS LEN BLAVATNIK MIKAEL DOLSTEN BETH JACOBS GEORGE E. THIBAULT MARY BRABECK ELAINE FUCHS JOHN E. KELLY III FRANK WILCZEK NANCY CANTOR ALICE P. GAST MEHMOOD KHAN DEREK YACH MARTIN CHALFIE BRIAN GREENE JEFFREY D. SACHS MICHAEL ZIGMAN MILTON L. COFIELD THOMAS L. HARRISON KATHE A. SACKLER KENNETH L. DAVIS THOMAS CAMPBELL JACKSON MORTIMER D. A. SACKLER INTERNATIONAL GOVERNORS CHAIRS EMERITI HONORARY LIFE GOVERNORS SETH F. BERKLEY TONI HOOVER JOHN E. SEXTON KAREN E. BURKE MANUEL CAMACHO SOLIS RAJENDRA K. PACHAURI TORSTEN N. WIESEL HERBERT J. KAYDEN GERALD CHAN RUSSELL READ JOHN F. NIBLACK S. “KRIS” GOPALAKRISHNAN PAUL STOFFELS PRESIDENT’S COUNCIL PETER AGRE PETER DOHERTY GERALD J. MCDOUGALL MARC TESSIER-LAVIGNE Nobel Laureate; Univ. Prof. and Director, Nobel Laureate; Researcher, St. Jude National Partner, Global Pharmaceutical President, The Rockefeller University Johns Hopkins Malaria Research Inst.,Dept. Children’s Research Hospital, Memphis, & Health Sciences Practice, MARY ANN TIGHE Molecular Microbiology and Immunology, Tennessee; Univ. of Melbourne, Australia PricewaterhouseCoopers LLP Chief Executive Officer, New York Tri-State Bloomberg School of Public Health MIKAEL DOLSTEN RICHARD MENSCHEL Region, CB Richard Ellis RICHARD AXEL President, Worldwide Research and Senior Director, Goldman Sachs SHIRLEY TILGHMAN Nobel Laureate; University Professor, Development; Senior Vice-President, Pfizer Inc. RONAY MENSCHEL President Emerita/Professor of Molecular Columbia Univ.; Investigator, HHMI MARCELO EBRARD CASAUBON Chairman of the Board, Phipps Houses; Board Biology, Princeton University DAVID BALTIMORE Former Mayor, Mexico City of Overseers, Weill Cornell Medical College XAVIER TRIAS Nobel Laureate; President Emeritus, Caltech EDMOND H. FISCHER HEATHER MUNROE-BLUM Mayor, Barcelona ETIENNE-EMILE BAULIEU Nobel Laureate; Professor Emeritus, Department Former Principal and Vice-Chancellor, FRANK WALSH Former President, of Biochemistry, University of Washington McGill University Chief Executive Officer, Ossianix, Inc. French Academy of Sciences JEROME I. FRIEDMAN FERID MURAD GERALD WEISSMANN PAUL BERG Nobel Laureate; Institute Professor Nobel Laureate; Director, IMM Center Prof. of Medicine, NY Univ. School Nobel Laureate; Professor Emeritus, Dept. & Professor of Physics, Emeritus, for Cell Signaling, The University of Texas of Medicine of Biochemistry, Stanford University Massachusetts Institute of Technology at Houston JOHN WHITEHEAD LEN BLAVATNIK JOSEPH GOLDSTEIN JOHN F. NIBLACK Former Chairman, Lower Manhattan Chairman, Access Industries, Inc. Nobel Laureate; Chairman, Molecular Former President, Pfizer Global Research & Development Corp.; Former Co-Chairman GÜNTER BLOBEL Genetics, Univ. of Texas Southwestern Development; Honorary Life Governor, of Goldman Sachs Nobel Laureate; Director, Laboratory for Medical Center The New York Academy of Sciences GEORGE WHITESIDES Cell Biology, The Rockefeller University S. GOPALAKRISHNAN PAUL NURSE Woodford L. & Ann A. Flowers University IRINA BOKOVA Executive Co-Chairman of the Board, Nobel Laureate; President, Professor, Harvard University Director General, United Nations Infosys Technologies Limited The Royal Society; Former President, TORSTEN N. WIESEL Educational, Scientific and Cultural PAUL GREENGARD The Rockefeller University Nobel Laureate; Chairman Emeritus, Organization (UNESCO) Nobel Laureate; Prof. of Molecular RICHARD ROBERTS The New York Academy of Sciences; SYDNEY BRENNER & Cellular Neuroscience, Nobel Laureate; Chief Scientific Officer, Former Secretary General, Human Frontier Nobel Laureate; Distinguished Prof., Salk Inst. The Rockefeller University New England Biolabs Science Program Organization; President MICHAEL S. BROWN GLENDA GREENWALD EDWARD F. ROVER Emeritus, The Rockefeller Univ. Nobel Laureate; Prof. of Molecular President, Aspen Brain Forum Foundation President, The Dana Foundation FRANK WILCZEK Genetics, Univ. of Texas Southwestern PETER GRUSS BENGT SAMUELSSON Nobel Laureate; Herman Feshbach Medical Center President, Max Planck Gesellschaft Nobel Laureate; Prof., Medical & Professor of Physics, Massachusetts Institute LINDA BUCK WILLIAM A. HASELTINE Physiological Chem., Karolinska Inst.; of Technology Nobel Laureate; Investigator for HHMI; President, The Haseltine Foundation for Former Chairman, The Nobel Foundation ERNST-LUDWIG WINNACKER Member of the Fred Hutchinson Cancer Medical Sciences and the Arts; Chairman, IVAN SEIDENBERG Secretary General, Human Frontier Research Center Haseltine Global Health, LLC Advisory Partner of Perella Weinberg Partners LP; Science Program Organization; Former KAREN E. BURKE ERIC KANDEL former Chairman, Verizon Communications Inc. Secretary General, European Research Dermatologist & Research Scientist; Nobel Laureate; Prof., Physiology & ISMAIL SERAGELDIN Council; Former President, Deutsche Honorary Life Governor, The New York Cell Biology, Columbia University Librarian of Alexandria, Director of the Forschungsgemeinschaft, Germany Academy of Sciences KIYOSHI KUROKAWA Bibliotheca Alexandria, The Library of ANDREW WITTY THOMAS R. CECH Former Science Advisor to the Prime Alexandria, Egypt Chief Executive Officer, GlaxoSmithKline Nobel Laureate; Distinguished Prof., Minister of Japan; Professor, National PHILLIP A. SHARP DATO ZAKRI ABDUL HAMID University of Colorado, Boulder Graduate Institute for Policy Studies (GRIPS) Nobel Laureate; Director, The McGovern Science Adviser to the Prime Minister MARTIN CHALFIE LEON LEDERMAN Institute, MIT Center for Cancer Research of Malaysia Nobel Laureate; William R. Kenan, Jr. Nobel Laureate; Pritzker Prof. of Science, ELLIOTT SIGAL ELIAS ZERHOUNI Prof. of Biological Sciences; Chair, Dept. Illinois Inst. of Tech.; Resident Scholar, Chief Scientific Officer, Bristol-Myers Squibb President, Global Research & of Biological Sciences, Columbia University Illinois Math & Science Academy MICHAEL SOHLMAN Development, Sanofi-aventis CECILIA CHAN GREGORY LUCIER Former Executive Director, The Nobel Foundation AHMED ZEWAIL Managing Director, Gold Avenue Ltd. Chairman and Chief Executive Officer, PAUL STOFFELS Nobel Laureate; Linus Pauling Chair of AARON J. CIECHANOVER Life Technologies Corporation Chief Scientific Officer, Johnson & Johnson; Chemistry and Physics, California Institute Nobel Laureate; Distinguished Research RODERICK MACKINNON member of the Johnson & Johnson of Technology Professor, Tumor and Vascular Biology Nobel Laureate; John D. Rockefeller, Executive Committee & Management GUANGZHAO ZHOU Research Center, Faculty of Medicine, Jr. Prof., The Rockefeller University; Committee; Worldwide Co-Chairman, Former Chairman, Chinese Association Technion-Israel Inst. of Tech., Haifa, Israel Investigator, HHMI Pharmaceuticals Group of Science & Technology TABLE OF CONTENTS PRESIDENT’S LETTER RESEARCH SPOTLIGHTS 6 New York Scientific Leadership: 46 The Feinstein Institute for Medical Research: From Dream to Reality Unlocking the Promise of Bioelectrics FEATURE ARTICLE 48 Hospital for Special Surgery: 8 New York: A Science State of Mind Revolutionizing Rheumatology Research through Genomics RESEARCH SPOTLIGHTS 12 University at Albany, SUNY: 50 Memorial Sloan-Kettering Cancer Center: The Rise of RNA as a New Target for Targeting Cancer Cells through Therapeutic Agents Genetic Engineering 14 Binghamton University, SUNY: FEATURE ARTICLE Greening the Tech Industry through 52 Local Players on the Global Stage Energy Savings RESEARCH SPOTLIGHTS 16 University at Buffalo, SUNY: 60 Icahn School of Medicine at Mount Sinai: Creating Nimble Nanomaterials Tailoring Treatment with Big Data 18 The City University of New York: 62 New York University: Interdisciplinary by Design On the CUSP of Data Science’s Watershed Moment FEATURE ARTICLE 20 Collaboration Central 64 Rensselear Polytechnic Institute: A High-Tech Home for Data Exploration RESEARCH SPOTLIGHTS 30 Cold Spring Harbor Laboratory: FEATURE ARTICLE A Translational Approach to 66 Corporate Research’s Weighty Role ‘Incurable Cancers’ RESEARCH SPOTLIGHTS 32 Columbia University: 72 University of Rochester: The Neuroscientific Basis of Human Seeking an Infinite Energy Source through Behavior and Disease Nuclear Fusion 34 Cornell University: 74 The Rockefeller University: Fueling the Tech Economy through Education A New Commitment to Personalized Medicine 36 Albert
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