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Expect the Unexpected: Building Business Value in a Changing World
Expect the Unexpected: Building business value in a changing world kpmg.com KPMG INTERNATIONAL PART 1 b | Expect the Unexpected: Building business value in a changing world In this report we offer a starting point for discussion. We present a system of ten sustainability megaforces that will impact each and every business over the next 20 years. We want to build awareness that these forces do not act alone in predictable ways. They are interconnected. They interact. Disclaimer: Throughout this document, "KPMG" ["we," "our," and "us"] refers to KPMG International, a Swiss entity that serves as a coordinating entity for a network of independent member firms operating under the KPMG name, KPMG's Climate Change and Sustainability practice, and/or to any one or more of such firms. KPMG International provides no client services. © 2012 KPMG International Cooperative (“KPMG International”), a Swiss entity. Member firms of the KPMG network of independent firms are affiliated with KPMG International. KPMG International provides no client services. All rights reserved. Expect the Unexpected: Building business value in a changing world | c Foreword usinesses today are operating in an ever more At KPMG’s network of firms we have always been at the interconnected and globalized world. Supply chains forefront of developments that shape business behavior. Bstretch across continents and are vulnerable to We are working with organizations to help them understand disruption. Consumer demands and government policies the forces at work that will influence markets and impact are changing rapidly and will impact your bottom line if your profitability in the medium to long term. -
The Relative Value of Alcohol May Be Encoded by Discrete Regions of the Brain, According to a Study of 24 Men Published This Week in Neuropsychopharmacology
PRESS RELEASE FROM NEUROPSYCHOPHARMACOLOGY (http://www.nature.com/npp) This press release is copyrighted to the journal Neuropsychopharmacology. Its use is granted only for journalists and news media receiving it directly from the Nature Publishing Group. *** PLEASE DO NOT REDISTRIBUTE THIS DOCUMENT *** EMBARGO: 1500 London time (GMT) / 1000 US Eastern Time Monday 03 March 2014 0000 Japanese time / 0200 Australian Eastern Time Tuesday 04 March 2014 Wire services’ stories must always carry the embargo time at the head of each item, and may not be sent out more than 24 hours before that time. Solely for the purpose of soliciting informed comment on this paper, you may show it to independent specialists - but you must ensure in advance that they understand and accept the embargo conditions. This press release contains: • Summaries of newsworthy papers: Brain changes in young smokers *PODCAST* To drink or not to drink? *PODCAST* • Geographical listing of authors PDFs of the papers mentioned on this release can be found in the Academic Journals section of the press site: http://press.nature.com Warning: This document, and the papers to which it refers, may contain sensitive or confidential information not yet disclosed to the public. Using, sharing or disclosing this information to others in connection with securities dealing or trading may be a violation of insider trading under the laws of several countries, including, but not limited to, the UK Financial Services and Markets Act 2000 and the US Securities Exchange Act of 1934, each of which may be subject to penalties and imprisonment. PICTURES: While we are happy for images from Neuropsychopharmacology to be reproduced for the purposes of contemporaneous news reporting, you must also seek permission from the copyright holder (if named) or author of the research paper in question (if not). -
Novartis Swaps Two Avexis Executives for One Following
No. 3969 August 23, 2019 and CSO that the Kaspars have not been involved in the Novartis subsidiary’s op- erations since early May. Asked whether more AveXis employees will exit the company due to the preclini- cal safety data manipulation revealed on 6 August or whether other actions will be taken by Novartis in relation to the matter, Althoff told Scrip: “We cannot comment on the specifics of who is involved, but we can confirm this issue was not widespread, ei- ther in our overall dataset nor in our com- pany or any function within our company and was limited to a few individuals.” Novartis CEO Vas Narasimhan said in a 7 August conference call about the Zol- gensma data controversy that the compa- ny was in the process of “exiting the small number of AveXis scientists involved” in the data manipulation, which occurred Novartis Swaps Two AveXis before Novartis bought the gene therapy firm. (Also see “Novartis CEO Explains De- lay In Telling US FDA About Zolgensma Executives For One Following Data Fraud: We Wanted To Understand It First” - Pink Sheet, 7 Aug, 2019.) Zolgensma Data Manipulation Novartis acquired AveXis for $8.7bn MANDY JACKSON [email protected] last year. (Also see “Novartis Goes Big On Gene Therapy With $8.7bn AveXis Acquisi- ovartis AG said when it disclosed the Zolgensma BLA was manipulated. Page tion” - Scrip, 9 Apr, 2018.) Zolgensma was that preclinical safety data for Zol- Bouchard, whose most recent function was the lead asset in AveXis’s R&D pipeline and Ngensma were manipulated in the bi- global head of preclinical safety for Novar- won US Food and Drug Administration ologic license application for the gene ther- tis Institutes of Biomedical Research (NIBR), approval in May, becoming the world’s apy that the company would be “exiting” was named senior vice president and chief most expensive drug with a $2m list price. -
The Alexandria Library, a Quantum-Chemical Database of Molecular Properties for Force field Development 9 2017 Received: October 1 1 1 Mohammad M
www.nature.com/scientificdata OPEN Data Descriptor: The Alexandria library, a quantum-chemical database of molecular properties for force field development 9 2017 Received: October 1 1 1 Mohammad M. Ghahremanpour , Paul J. van Maaren & David van der Spoel Accepted: 19 February 2018 Published: 10 April 2018 Data quality as well as library size are crucial issues for force field development. In order to predict molecular properties in a large chemical space, the foundation to build force fields on needs to encompass a large variety of chemical compounds. The tabulated molecular physicochemical properties also need to be accurate. Due to the limited transparency in data used for development of existing force fields it is hard to establish data quality and reusability is low. This paper presents the Alexandria library as an open and freely accessible database of optimized molecular geometries, frequencies, electrostatic moments up to the hexadecupole, electrostatic potential, polarizabilities, and thermochemistry, obtained from quantum chemistry calculations for 2704 compounds. Values are tabulated and where available compared to experimental data. This library can assist systematic development and training of empirical force fields for a broad range of molecules. Design Type(s) data integration objective • molecular physical property analysis objective Measurement Type(s) physicochemical characterization Technology Type(s) Computational Chemistry Factor Type(s) Sample Characteristic(s) 1 Uppsala Centre for Computational Chemistry, Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Husargatan 3, Box 596, SE-75124 Uppsala, Sweden. Correspondence and requests for materials should be addressed to D.v.d.S. (email: [email protected]). -
Carbon Dioxide Adsorption by Metal Organic Frameworks (Synthesis, Testing and Modeling)
Western University Scholarship@Western Electronic Thesis and Dissertation Repository 8-8-2013 12:00 AM Carbon Dioxide Adsorption by Metal Organic Frameworks (Synthesis, Testing and Modeling) Rana Sabouni The University of Western Ontario Supervisor Prof. Sohrab Rohani The University of Western Ontario Graduate Program in Chemical and Biochemical Engineering A thesis submitted in partial fulfillment of the equirr ements for the degree in Doctor of Philosophy © Rana Sabouni 2013 Follow this and additional works at: https://ir.lib.uwo.ca/etd Part of the Other Chemical Engineering Commons Recommended Citation Sabouni, Rana, "Carbon Dioxide Adsorption by Metal Organic Frameworks (Synthesis, Testing and Modeling)" (2013). Electronic Thesis and Dissertation Repository. 1472. https://ir.lib.uwo.ca/etd/1472 This Dissertation/Thesis is brought to you for free and open access by Scholarship@Western. It has been accepted for inclusion in Electronic Thesis and Dissertation Repository by an authorized administrator of Scholarship@Western. For more information, please contact [email protected]. i CARBON DIOXIDE ADSORPTION BY METAL ORGANIC FRAMEWORKS (SYNTHESIS, TESTING AND MODELING) (Thesis format: Integrated Article) by Rana Sabouni Graduate Program in Chemical and Biochemical Engineering A thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy The School of Graduate and Postdoctoral Studies The University of Western Ontario London, Ontario, Canada Rana Sabouni 2013 ABSTRACT It is essential to capture carbon dioxide from flue gas because it is considered one of the main causes of global warming. Several materials and various methods have been reported for the CO2 capturing including adsorption onto zeolites, porous membranes, and absorption in amine solutions. -
Antidepressants During Pregnancy and Fetal Development
PRESS RELEASE FROM NEUROPSYCHOPHARMACOLOGY (http://www.nature.com/npp) This press release is copyrighted to the journal Neuropsychopharmacology. Its use is granted only for journalists and news media receiving it directly from the Nature Publishing Group. *** PLEASE DO NOT REDISTRIBUTE THIS DOCUMENT *** EMBARGO: 1500 London time (BST) / 1000 US Eastern Time / 2300 Japanese time Monday 19 May 2014 0000 Australian Eastern Time Tuesday 20 May 2014 Wire services’ stories must always carry the embargo time at the head of each item, and may not be sent out more than 24 hours before that time. Solely for the purpose of soliciting informed comment on this paper, you may show it to independent specialists - but you must ensure in advance that they understand and accept the embargo conditions. A PDF of the paper mentioned on this release can be found in the Academic Journals section of the press site: http://press.nature.com Warning: This document, and the papers to which it refers, may contain sensitive or confidential information not yet disclosed to the public. Using, sharing or disclosing this information to others in connection with securities dealing or trading may be a violation of insider trading under the laws of several countries, including, but not limited to, the UK Financial Services and Markets Act 2000 and the US Securities Exchange Act of 1934, each of which may be subject to penalties and imprisonment. PICTURES: While we are happy for images from Neuropsychopharmacology to be reproduced for the purposes of contemporaneous news reporting, you must also seek permission from the copyright holder (if named) or author of the research paper in question (if not). -
The EBRARY Platform
One eContent platform. Many ways to use it. Subscribe, Purchase or Customize Share, Archive & Distribute Integrate THE EBRARY PLatFORM Our eContent Your eContent eBooks, reports, journals, Theses, dissertations, images, journals, sheet music, and more eBooks – anything in PDF Subscribe Purchase Customize Share Archive Distribute SULAIR Select Collections SUL EBRARY COLLECTIONS Select Collections TABLE OF CONTENTS Infotools All ebrary Collections CONTRIBUTORS Byron Hoyt Sheet Music (Browse) INTRODUCTION Immigration Commision Reports (Dillingham) Contents BUSINESS: A USER’S GUIDE Women and Child Wage Earners in the U.S. CSLI Linguistics and Philosophy BEST PRACTICE SUL Books in the Public Domain MANAGEMENT CHECKLISTS Medieval and Modern Thought Text Project ACTIONLISTS MANAGEMENT LIBRARY BUSINESS THINKERS AND MANA DICTIONARY WORLD BUSINESS ALMANAC Highlights Notes BUSINESS INFORMATION SOURC INDEX CREDITS InfoTools Integrates Define Explain Locate multiple online Translate Search Document... resources Search All Documents... Search Web Search Catalog with one Highlight Add to Bookshelf customizable Copy Text... Copy Bookmark interface. Print... Print Again Toggle Automenu Preferences... Help About ebrary Reader... EASY TO USE. Subscribe, Purchase AFFORDABLE. or Customize your ALW ay S AVAILABLE. eBook selection NO CHECK-OUTS. Un I Q U E S U B SC R I B E T O G R OWI ng E B O O K D ataba S E S W I T H SIMULtanEOUS, MULTI-USER ACCESS. RESEARCH TOOLS. ACADEMIC DATABASES Academic Complete includes all academic databases listed below. FREE MARCS. # of # of Subject Titles* Subject Titles* Business & Economics 6,300 Language, Literature 3,400 & Linguistics “ebrary’s content is Computers & IT 2,800 Law, International Relations 3,800 multidisciplinary and Education 2,300 & Public Policy Engineering & Technology 3,700 supports our expanding Life Sciences 2,000 (includes Biotechnolgy, History & Political Science 4,800 Agriculture, and (also includes a bonus selection faculty and curriculum. -
Advertising (PDF)
Edited by John Cairns, Cold Spring Harbor Laboratory; Gunther S. Stent, University of California, Berkeley; James D. Watson, Harvard University his landmark collection of essays, written by pioneers in the field of molecular biology, was first published T in 1966 as a 60th birthday tribute to Max Delbrück, a formative influence on many of today’s leading sci- entists. The book served as a valuable historical record as well as a remarkable portrait of a small, pioneering, close- knit scientific community that focused intensely on the most important questions in biology. This centennial edi- tion reflects a more personal side of Delbrück, and includes a series of photographs from his family’s albums. “Delbrück had been a kind of Gandhi of biology...It was his extraordinary personality that made him the spiritu- al force which affected the scientific and personal lives of so many people.” —Gunther S. Stent 2007, 394 pp., illus., timeline, photo gallery Hardcover $29 ISBN 978-087969800-3 CONTENTS Note from the Publisher The Injection of DNA into Cells Bacterial Conjugation Quantitatitve Tumor Virology Preface to the First Edition by Phage Elie L. Wollman H. Rubin John Cairns, Gunther S. Stent, James A.D. Hershey Story and Structure of the The Natural Selection Theory D. Watson Transfer of Parental Material to λ Transducing Phage of Antibody Formation; Ten Preface to the Expanded Edition Progeny J. Weigle Years Later John Cairns Lloyd M. Kozloff V. DNA Niels K. Jerne Electron Microscopy of Developing Growing Up in the Phage Group Cybernetics of the Insect I. ORIGINS OF MOLECULAR Optomotor Response BIOLOGY Bacteriophage J.D. -
Winter for the Membership of the American Crystallographic Association, P.O
AMERICAN CRYSTALLOGRAPHIC ASSOCIATION NEWSLETTER Number 4 Winter 2004 ACA 2005 Transactions Symposium New Horizons in Structure Based Drug Discovery Table of Contents / President's Column Winter 2004 Table of Contents President's Column Presidentʼs Column ........................................................... 1-2 The fall ACA Council Guest Editoral: .................................................................2-3 meeting took place in early 2004 ACA Election Results ................................................ 4 November. At this time, News from Canada / Position Available .............................. 6 Council made a few deci- sions, based upon input ACA Committee Report / Web Watch ................................ 8 from the membership. First ACA 2004 Chicago .............................................9-29, 38-40 and foremost, many will Workshop Reports ...................................................... 9-12 be pleased to know that a Travel Award Winners / Commercial Exhibitors ...... 14-23 satisfactory venue for the McPherson Fankuchen Address ................................38-40 2006 summer meeting was News of Crystallographers ...........................................30-37 found. The meeting will be Awards: Janssen/Aminoff/Perutz ..............................30-33 held at the Sheraton Waikiki Obituaries: Blow/Alexander/McMurdie .................... 33-37 Hotel in Honolulu, July 22-27, 2005. Council is ACA Summer Schools / 2005 Etter Award ..................42-44 particularly appreciative of Database Update: -
Annual Copyright License for Corporations
Responsive Rights - Annual Copyright License for Corporations Publisher list Specific terms may apply to some publishers or works. Please refer to the Annual Copyright License search page at http://www.copyright.com/ to verify publisher participation and title coverage, as well as any applicable terms. Participating publishers include: Advance Central Services Advanstar Communications Inc. 1105 Media, Inc. Advantage Business Media 5m Publishing Advertising Educational Foundation A. M. Best Company AEGIS Publications LLC AACC International Aerospace Medical Associates AACE-Assn. for the Advancement of Computing in Education AFCHRON (African American Chronicles) AACECORP, Inc. African Studies Association AAIDD Agate Publishing Aavia Publishing, LLC Agence-France Presse ABC-CLIO Agricultural History Society ABDO Publishing Group AHC Media LLC Abingdon Press Ahmed Owolabi Adesanya Academy of General Dentistry Aidan Meehan Academy of Management (NY) Airforce Historical Foundation Academy Of Political Science Akademiai Kiado Access Intelligence Alan Guttmacher Institute ACM (Association for Computing Machinery) Albany Law Review of Albany Law School Acta Ecologica Sinica Alcohol Research Documentation, Inc. Acta Oceanologica Sinica Algora Publishing ACTA Publications Allerton Press Inc. Acta Scientiae Circumstantiae Allied Academies Inc. ACU Press Allied Media LLC Adenine Press Allured Business Media Adis Data Information Bv Allworth Press / Skyhorse Publishing Inc Administrative Science Quarterly AlphaMed Press 9/8/2015 AltaMira Press American -
Flexible Heuristic Algorithm for Automatic Molecule Fragmentation: Application to the UNIFAC Group Contribution Model Simon Müller*
Müller J Cheminform (2019) 11:57 https://doi.org/10.1186/s13321-019-0382-3 Journal of Cheminformatics RESEARCH ARTICLE Open Access Flexible heuristic algorithm for automatic molecule fragmentation: application to the UNIFAC group contribution model Simon Müller* Abstract A priori calculation of thermophysical properties and predictive thermodynamic models can be very helpful for developing new industrial processes. Group contribution methods link the target property to contributions based on chemical groups or other molecular subunits of a given molecule. However, the fragmentation of the molecule into its subunits is usually done manually impeding the fast testing and development of new group contribution methods based on large databases of molecules. The aim of this work is to develop strategies to overcome the challenges that arise when attempting to fragment molecules automatically while keeping the defnition of the groups as simple as possible. Furthermore, these strategies are implemented in two fragmentation algorithms. The frst algorithm fnds only one solution while the second algorithm fnds all possible fragmentations. Both algorithms are tested to frag- ment a database of 20,000 molecules for use with the group contribution model Universal Quasichemical Func- tional Group Activity Coefcients+ (UNIFAC). Comparison of the results with a reference database shows that both algorithms are capable of successfully fragmenting all the molecules automatically. Furthermore, when applying them on a larger database it is shown, that the newly developed algorithms are capable of fragmenting structures previously thought not possible to fragment. Keywords: Molecule fragmentation, Cheminformatics, RDKit, Property prediction, Group contribution method, UNIFAC, Incrementation Introduction named QSPR methods (Quantitative Structure Property Cheminformatics is a growing feld due to the increas- Relationship). -
Chemical Database Projects Delivered by RSC Escience
Chemical Database Projects Delivered by RSC eScience at the FDA Meeting “Development of a Freely Distributable Data System for the Registration of Substances” Antony Williams RSC eScience . What was once just ChemSpider is much more… . ChemSpider Reactions . Chemicals Validation and Standardization Platform . Learn Chemistry Wiki . National Chemical Database Service . Open PHACTS . PharmaSea . Global Chemistry Hub We are known for ChemSpider… . The Free Chemical Database . A central hub for chemists to source information . >28 million unique chemical records . Aggregated from >400 data sources . Chemicals, spectra, CIF files, movies, images, podcasts, links to patents, publications, predictions . A central hub for chemists to deposit & curate data We Want to Answer Questions . Questions a chemist might ask… . What is the melting point of n-heptanol? . What is the chemical structure of Xanax? . Chemically, what is phenolphthalein? . What are the stereocenters of cholesterol? . Where can I find publications about xylene? . What are the different trade names for Ketoconazole? . What is the NMR spectrum of Aspirin? . What are the safety handling issues for Thymol Blue? I want to know about “Vincristine” Vincristine: Identifiers and Properties Vincristine: Vendors and Sources Vincristine: Articles How did we build it? . We deal in Molfiles or SDF files – with coordinates . Deposit anything that has an InChI – we support what InChI can handle, good and bad . Standardization based on “InChI standardization” . InChIs aggregate (certain) tautomers The InChI Identifier Downsides of InChI . Good for small molecules – but no polymers, issues with inorganics, organometallics, imperfect stereochemistry. ChemSpider is “small molecules” . InChI used as the “deduplicator” – FIRST version of a compound into the database becomes THE structure to deduplicate against… Side Effects of InChI Usage SMILES by comparison… Side Effects of InChI Usage Searches: The INTERNET Search by InChI ChemSpider Google Search http://www.chemspider.com/google/ How did we build it? .