1 Phytochemical and Biological Evaluation of Two Vietnamese
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Neuroprotective Mechanisms of Red Clover and Soy Isoflavones in Parkinson’S Disease Models
bioRxiv preprint doi: https://doi.org/10.1101/2020.12.01.391268; this version posted July 5, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson’s disease models Aurélie de Rus Jacquet1,2*, Abeje Ambaw3,4, Mitali Arun Tambe1,5, Sin Ying Ma1, Michael Timmers6,7, Mary H. Grace6, Qing-Li Wu8, James E. Simon8, George P. McCabe9, Mary Ann Lila6, Riyi Shi3,10,11, Jean-Christophe Rochet1,11*. 1Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, 47907, USA 2Present affiliations: Centre de Recherche du CHU de Québec, Axe Neurosciences, Québec, QC, G1V 4G2, Canada, and Département de Psychiatrie & Neurosciences, Université Laval, Québec, QC, G1V 0A6, Canada 3Department of Basic Medical Sciences, Purdue University, West Lafayette, IN, 47907, USA 4Present affiliation: Physiology Department, Monterey Peninsula College, Monterey, CA, 93940, USA. 5Present affiliation: National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA 6Plants for Human Health Institute, Department of Food Bioprocessing and Nutrition Sciences, North Carolina State University, Kannapolis, NC, 28081, USA 7Present affiliation: Berry Blue, Kannapolis, NC, 28081, USA 8Department of Plant Biology, Rutgers University, New Brunswick, NJ, 08901, USA 9Department of Statistics, Purdue University, West Lafayette, IN 47907, USA 10Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA 11Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN, 47907, USA * Corresponding authors: Jean-Christophe Rochet: [email protected] Aurélie de Rus Jacquet: [email protected] 1 bioRxiv preprint doi: https://doi.org/10.1101/2020.12.01.391268; this version posted July 5, 2021. -
Glucosylation of Isoflavonoids in Engineered Escherichia Coli
Mol. Cells 2014; 37(2): 172-177 http://dx.doi.org/10.14348/molcells.2014.2348 Molecules and Cells http://molcells.org Established in 1990 Glucosylation of Isoflavonoids in Engineered Escherichia coli Ramesh Prasad Pandey1,3, Prakash Parajuli1,3, Niranjan Koirala1, Joo Ho Lee1, Yong Il Park2, and Jae Kyung Sohng1,* A glycosyltransferase, YjiC, from Bacillus licheniformis INTRODUCTION has been used for the modification of the commercially available isoflavonoids genistein, daidzein, biochanin A Isoflavonoids are biologically active secondary metabolites and formononetin. The in vitro glycosylation reaction, us- which are produced by most leguminous plants. However, non- ing UDP-α-D-glucose as a donor for the glucose moiety leguminous plants have also been reported to produce isofla- and aforementioned four acceptor molecules, showed the vonoids. Structurally, isoflavonoids differ from flavonoids ac- prominent glycosylation at 4′ and 7 hydroxyl groups, but cording to the position of the phenolic ring B attachment at the not at the 5th hydroxyl group of the A-ring, resulting in the C-3 position of the C-ring, instead of at the C-2 position in fla- production of genistein 4′-O-β-D-glucoside, genistein 7-O- vonoids. A number of isoflavonoid derivatives (more than 1600 β-D-glucoside (genistin), genistein 4′,7-O-β-D-diglucoside, to date) have been identified from different sources (Veitch, biochanin A-7-O-β-D-glucoside (sissotrin), daidzein 4′-O-β- 2007; 2013). In plants, the biosynthetic pathway of most of the D-glucoside, daidzein 7-O-β-D-glucoside (daidzin), daidzein flavonoid groups of compound share the same chalcone inter- 4′, 7-O-β-D-diglucoside, and formononetin 7-O-β-D-gluco- mediate (Pandey and Sohng, 2013). -
Phytoalexins: Current Progress and Future Prospects
Phytoalexins: Current Progress and Future Prospects Edited by Philippe Jeandet Printed Edition of the Special Issue Published in Molecules www.mdpi.com/journal/molecules Philippe Jeandet (Ed.) Phytoalexins: Current Progress and Future Prospects This book is a reprint of the special issue that appeared in the online open access journal Molecules (ISSN 1420-3049) in 2014 (available at: http://www.mdpi.com/journal/molecules/special_issues/phytoalexins-progress). Guest Editor Philippe Jeandet Laboratory of Stress, Defenses and Plant Reproduction U.R.V.V.C., UPRES EA 4707, Faculty of Sciences, University of Reims, PO Box. 1039, 51687 Reims cedex 02, France Editorial Office MDPI AG Klybeckstrasse 64 Basel, Switzerland Publisher Shu-Kun Lin Managing Editor Ran Dang 1. Edition 2015 MDPI • Basel • Beijing ISBN 978-3-03842-059-0 © 2015 by the authors; licensee MDPI, Basel, Switzerland. All articles in this volume are Open Access distributed under the Creative Commons Attribution 3.0 license (http://creativecommons.org/licenses/by/3.0/), which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. However, the dissemination and distribution of copies of this book as a whole is restricted to MDPI, Basel, Switzerland. III Table of Contents About the Editor ............................................................................................................... VII List of -
Amorpha Fruticosa – a Noxious Invasive Alien Plant in Europe Or a Medicinal Plant Against Metabolic Disease?
fphar-08-00333 June 6, 2017 Time: 18:44 # 1 REVIEW published: 08 June 2017 doi: 10.3389/fphar.2017.00333 Amorpha fruticosa – A Noxious Invasive Alien Plant in Europe or a Medicinal Plant against Metabolic Disease? Ekaterina Kozuharova1, Adam Matkowski2, Dorota Wo´zniak2, Rumiana Simeonova3, Zheko Naychov4, Clemens Malainer5, Andrei Mocan6,7, Seyed M. Nabavi8 and Atanas G. Atanasov9,10,11* 1 Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Sofia, Sofia, Bulgaria, 2 Department of Pharmaceutical Biology with Botanical Garden of Medicinal Plants, Medical University of Wroclaw, Poland, 3 Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, Sofia, Bulgaria, 4 Sofia University St. Kliment Ohridski, Faculty of Medicine, Department of Surgery, Obstetrics and Gynecology, Division of Cardiac Surgery, University Hospital Lozenetz, Sofia, Bulgaria, 5 Independent Researcher, Vienna, Austria, 6 Department of Pharmaceutical Botany, Iuliu Ha¸tieganuUniversity of Medicine and Pharmacy, Cluj-Napoca, Romania, 7 ICHAT and Institute for Life Sciences, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania, 8 Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran, 9 Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Poland, 10 Department of Pharmacognosy, University of Vienna, Vienna, Austria, 11 Department of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria Amorpha fruticosa L. (Fabaceae) is a shrub native to North America which has been Edited by: Kalin Yanbo Zhang, cultivated mainly for its ornamental features, honey plant value and protective properties University of Hong Kong, Hong Kong against soil erosion. -
Germination and Salinity Tolerance of Seeds of Sixteen Fabaceae Species in Thailand for Reclamation of Salt-Affected Lands
BIODIVERSITAS ISSN: 1412-033X Volume 21, Number 5, May 2020 E-ISSN: 2085-4722 Pages: 2188-2200 DOI: 10.13057/biodiv/d210547 Germination and salinity tolerance of seeds of sixteen Fabaceae species in Thailand for reclamation of salt-affected lands YONGKRIAT KU-OR1, NISA LEKSUNGNOEN1,2,♥, DAMRONGVUDHI ONWIMON3, PEERAPAT DOOMNIL1 1Department of Forest Biology, Faculty of Forestry, Kasetsart University. 50 Phahonyothin Rd, Lat yao, Chatuchak, Bangkok 10900, Thailand 2Center for Advanced Studies in Tropical Natural Resources, National Research University, Kasetsart University. 50 Phahonyothin Rd, Lat yao, Chatuchak, Bangkok 10900, Thailand. ♥email: [email protected] 3Department of Agronomy, Faculty of Agriculture, Kasetsart University. 50 Phahonyothin Rd, Lat Yao, Chatuchak, Bangkok 10900, Thailand. Manuscript received: 26 March 2020. Revision accepted: 24 April 2020. Abstract. Ku-Or Y, Leksungnoen N, Onwinom D, Doomnil P. 2020. Germination and salinity tolerance of seeds of sixteen Fabaceae species in Thailand for reclamation of salt-affected lands. Biodiversitas 21: 2188-2200. Over the years, areas affected by salinity have increased dramatically in Thailand, resulting in an urgent need for reclamation of salt-affected areas using salinity tolerant plant species. In this context, seed germination is an important process in plant reproduction and dispersion. This research aimed to study the ability of 16 fabaceous species to germinate and tolerate salt concentrations of at 6 different levels (concentration of sodium chloride solution, i.e., 0, 8, 16, 24, 32, and 40 dS m-1). The germination test was conducted daily for 30 days, and parameters such as germination percentage, germination speed, and germination synchrony were calculated. The electrical conductivity (EC50) was used to compare the salt-tolerant ability among the 16 species. -
And S-Equol and Implication of Transactivation Functions (AF-1 and AF-2) in Estrogen Receptor-Induced Transcriptional Activity
Nutrients 2010, 2, 340-354; doi:10.3390/nu2030340 OPEN ACCESS nutrients ISSN 2072-6643 www.mdpi.com/journal/nutrients Communication Comparative Effects of R- and S-equol and Implication of Transactivation Functions (AF-1 and AF-2) in Estrogen Receptor-Induced Transcriptional Activity Svitlana Shinkaruk 1, Charlotte Carreau 1, Gilles Flouriot 2, Catherine Bennetau-Pelissero 1 and Mylène Potier 1,* 1 ENITA de Bordeaux, Unité Micronutriments Reproduction Santé, 1 Cours du Général de Gaulle, CS 40201, F-33175 Gradignan cedex, France; E-Mails: [email protected] (S.S); [email protected] (C.C.); [email protected] (C.B.-P.); 2 CNRS UMR 6026, 35042, Equipe "Récepteur des œstrogènes et destinée cellulaire", Rennes cedex, France; E-Mail: [email protected] * Author to whom correspondence should be addressed: E-Mail: [email protected]. Received: 4 January 2010; in revised form: 20 February 2010 / Accepted: 25 February 2010 / Published: 15 March 2010 Abstract: Equol, one of the main metabolites of daidzein, is a chiral compound with pleiotropic effects on cellular signaling. This property may induce activation/inhibition of the estrogen receptors (ER) or and therefore, explain the beneficial/deleterious effects of equol on estrogen-dependent diseases. With its asymmetric centre at position C-3, equol can exist in two enantiomeric forms (R- and S-equol). To elucidate the yet unclear mechanisms of ER activation/inhibition by equol, we performed a comprehensive analysis of ER and ER transactivation by racemic equol, as well as by enantiomerically pure forms. Racemic equol was prepared by catalytic hydrogenation from daidzein and separated into enantiomers by chiral HPLC. -
Xxx-Xxx, Xxxx
PSRU Journal of Science and Technology 5(3): 74-96, 2020 ความหลากหลายของพรรณพืชในวัดป่าเขาคงคา อ าเภอครบุรี จังหวัดนครราชสีมา PLANT DIVERSITY IN KHAO KHONG KHA FOREST MONASTERY KHON BURI DISTRICT, NAKHON RATCHASIMA PROVINCE เทียมหทัย ชูพันธ์* นาริชซ่า วาดี ศรัญญา กล้าหาญ สุนิษา ยิ้มละมัย และ สุวรรณี อุดมทรัพย์ Thiamhathai Choopan*, Narissa Wadee, Saranya Klahan, Sunisa Yimlamai and Suwannee Udomsub คณะวิทยาศาสตร์และเทคโนโลยี มหาวิทยาลัยราชภัฏนครราชสีมา Faculty of Science and Technology, Nakhon Ratchasima Rajabhat University *corresponding author e-mail: [email protected] (Received: 27 July 2020; Revised: 8 October 2020; Accepted: 9 October 2020) บทคัดย่อ การวิจัยครั้งนี้เป็นการศึกษาความหลากหลายของพรรณพืชในวัดป่าเขาคงคา อ าเภอครบุรี จังหวัดนครราชสีมา ด้วยการสุ่มวางแปลงตัวอย่าง จ านวน 18 แปลง ขนาด 2020 เมตร เพื่อส ารวจ ไม้ต้น และขนาด 55 เมตร เพื่อส ารวจไม้พื้นล่างร่วมกับการส ารวจตามเส้นทางศึกษาธรรมชาติ ผลการศึกษาพบว่ามีไม้ต้น จ านวน 38 วงศ์ 83 สกุล 98 ชนิด โดยไม้ต้นชนิดที่พบมากที่สุด ได้แก่ ติ้วเกลี้ยง (Cratoxylum cochinchinense (Lour.) Blume) รองลงมา คือ เสี้ยวป่า (Bauhinia saccocalyx Pierre) และแดง (Xylia xylocarpa (Roxb.) W. Theob. var. kerrii (Craib & Hutch.) I.C. Nielsen) ตามล าดับ ส่วนไม้ต้นชนิดที่มีค่าดัชนีความส าคัญสูงที่สุด คือ เสี้ยวป่า ติ้วเกลี้ยง และแดง ตามล าดับ ค่าดัชนี ความหลากหลายของไม้ต้น มีค่าเท่ากับ 3.6656 ค่าความสม่ าเสมอในการกระจายตัว มีค่าเท่ากับ 0.7995 ค่าความหลากหลาย มีค่าเท่ากับ 39.0785 นอกจากนั้นพบว่ามีไม้พื้นล่าง จ านวน 61 วงศ์ 137 สกุล 145 ชนิด ไม้พื้นล่างชนิดที่พบมากที่สุด ได้แก่ พลูช้าง (Scindapus officinalis -
Medicinal Uses, Phytochemistry and Pharmacology of Pongamia Pinnata (L.) Pierre: a Review
Journal of Ethnopharmacology 150 (2013) 395–420 Contents lists available at ScienceDirect Journal of Ethnopharmacology journal homepage: www.elsevier.com/locate/jep Review Medicinal uses, phytochemistry and pharmacology of Pongamia pinnata (L.) Pierre: A review L.M.R. Al Muqarrabun a, N. Ahmat a,n, S.A.S. Ruzaina a, N.H. Ismail a, I. Sahidin b a Faculty of Applied Sciences, Universiti Teknologi MARA (UiTM), 40450 Shah Alam, Selangor, Malaysia b Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Haluoleo University (Unhalu), 93232 Kendari, Southeast Sulawesi, Indonesia article info abstract Article history: Ethnopharmacological relevance: Pongamia pinnata (L.) Pierre is one of the many plants with diverse Received 10 April 2013 medicinal properties where all its parts have been used as traditional medicine in the treatment and Received in revised form prevention of several kinds of ailments in many countries such as for treatment of piles, skin diseases, 19 August 2013 and wounds. Accepted 20 August 2013 Aim of this review: This review discusses the current knowledge of traditional uses, phytochemistry, Available online 7 September 2013 biological activities, and toxicity of this species in order to reveal its therapeutic and gaps requiring Keywords: future research opportunities. Pongamia pinnata Material and methods: This review is based on literature study on scientific journals and books from Fabaceae library and electronic sources such as ScienceDirect, PubMed, ACS, etc. Anti-diabetic Results: Several different classes of flavonoid derivatives, such as flavones, flavans, and chalcones, and Anti-inflammatory Karanjin several types of compounds including terpenes, steroid, and fatty acids have been isolated from all parts Pongamol of this plant. -
Neuroprotective Mechanisms of Red Clover and Soy Isoflavones in Parkinson’S Disease Models
bioRxiv preprint doi: https://doi.org/10.1101/2020.12.01.391268; this version posted January 1, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson’s disease models Aurélie de Rus Jacquet1,2*, Abeje Ambaw3,4, Mitali Arun Tambe1,5, Sin Ying Ma1, Michael Timmers6,7, Qing-Li Wu8, James E. Simon8, George P. McCabe9, Mary Ann Lila6, Riyi Shi3,10,11, Jean-Christophe Rochet1,11*. 1Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, 47907, USA 2Present affiliations: Centre de Recherche du CHU de Québec, Axe Neurosciences, Québec, QC, G1V 4G2, Canada, and Département de Psychiatrie & Neurosciences, Université Laval, Québec, QC, G1V 0A6, Canada 3Department of Basic Medical Sciences, Purdue University, West Lafayette, IN, 47907, USA 4Present affiliation: Physiology Department, Monterey Peninsula College, Monterey, CA, 93940, USA. 5Present affiliation: National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA 6Plants for Human Health Institute, Department of Food Bioprocessing and Nutrition Sciences, North Carolina State University, Kannapolis, NC, 28081, USA 7Present affiliation: Berry Blue, Kannapolis, NC, 28081, USA 8Department of Plant Biology, Rutgers University, New Brunswick, NJ, 08901, USA 9Department of Statistics, Purdue University, West Lafayette, IN 47907, USA 10Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA 11Purdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN, 47907, USA * Corresponding authors: Jean-Christophe Rochet: [email protected] Aurélie de Rus Jacquet: [email protected] 1 bioRxiv preprint doi: https://doi.org/10.1101/2020.12.01.391268; this version posted January 1, 2021. -
CHAPTER ONE INTRODUCTION 1.1 Background of the Study
CHAPTER ONE INTRODUCTION 1.1 Background of the study Throughout history, natural products have continued to play significant role as medicines and serve as repository of numerous bioactive compounds that serve as important leads in drug discovery (Dias et al., 2012). The significance of natural product based medicines is demonstrated by the reliance of more than half of the world’s population on natural products for their primary health care (Ekeanyanwu, 2011). The role of natural products in meeting the health needs of the Nigerian population has been stressed in many studies (Sofowora, 1982; Osemene et al., 2013). These natural products are rarely used solely for a particular disease condition. In some cases, a particular herbal product may be used for the treatment of related disease conditions or disease conditions with similar pathogenesis. There are situations where single herbal product is used for numerous unrelated disease conditions and for general body healing – this is the category where traditional use of Millettia aboensis falls. The contribution of natural products in disease control has been well acclaimed; however, the use of many plant based medicines for the treatment of disease conditions is yet to be fully accepted due to lack of scientific evidence on their efficacy and safety (Firenzuoli and Gori, 2007). The knowledge and uses of some medicinal plants are still based on cultural or folkloric believes. The full therapeutic potentials of herbal products would optimally be harnessed when their efficacy and toxicity are clearly validated and documented using scientific procedures. 1 Millettia aboensis is one of the plants considered to be an all-purpose plant in most parts of Africa because of the multiplicity of its use (Banzouzi et al., 2008). -
Systematic Conservation Planning in Thailand
SYSTEMATIC CONSERVATION PLANNING IN THAILAND DARAPORN CHAIRAT Thesis submitted in total fulfilment for the degree of Doctor of Philosophy BOURNEMOUTH UNIVERSITY 2015 This copy of the thesis has been supplied on condition that, anyone who consults it, is understood to recognize that its copyright rests with its author. Due acknowledgement must always be made of the use of any material contained in, or derived from, this thesis. i ii Systematic Conservation Planning in Thailand Daraporn Chairat Abstract Thailand supports a variety of tropical ecosystems and biodiversity. The country has approximately 12,050 species of plants, which account for 8% of estimated plant species found globally. However, the forest cover of Thailand is under threats: habitat degradation, illegal logging, shifting cultivation and human settlement are the main causes of the reduction in forest area. As a result, rates of biodiversity loss have been high for some decades. The most effective tool to conserve biodiversity is the designation of protected areas (PA). The effective and most scientifically robust approach for designing networks of reserve systems is systematic conservation planning, which is designed to identify conservation priorities on the basis of analysing spatial patterns in species distributions and associated threats. The designation of PAs of Thailand were initially based on expert consultations selecting the areas that are suitable for conserving forest resources, not systematically selected. Consequently, the PA management was based on individual management plans for each PA. The previous work has also identified that no previous attempt has been made to apply the principles and methods of systematic conservation planning. Additionally, tree species have been neglected in previous analyses of the coverage of PAs in Thailand. -
The Hongmu Challenge: a Briefing for the 66 Th Meeting of the CITES Standing Committee, January 2016 Acknowledgements
The hongmu Challenge: A briefing for the 66 th meeting of the CITES Standing Committee, January 2016 ACKNOwLEDgEmENTS This briefing was written and edited by the Environmental Investigation Agency (EIA). INTRODUCTION This document has been produced with the financial assistance of UKaid, the European Union, the Norwegian Agency for Development The Hongmu sector is a significant Cooperation (NORAD), The Tilia Fund and Good Energies Foundation. The contents of this threat to the select group of timber publication are the sole responsibility of EIA. species targeted and constitutes a pressing conservation challenge for CITES and its Parties. January 2016 Since 2009, Asian demand has boomed for luxury furniture made with rare, high-value and deeply © Environmental Investigation Agency 2016 hued rosewoods, mahoganies and ebonies. Principally targeting 33 species within the All images © EIA unless otherwise stated. Pterocarpus , Diospyros , Dalbergia , Millettia and Cassia genera, sales in China’s Hongmu sector Report design: exceeded $25 billion in 2014. www.designsolutions.me.uk The sector is driving systematic illegal and unsustainable extraction at unprecedented rates and scales. Across Asia, Africa and Latin America, the nature of the industry is the same – unsustainable extraction leads to domestic protection which is then undermined by smuggling aided by corrupt officials; finally, better- governed range states seek CITES protections. Once CITES regulations come into force or when resources become exhausted, the criminal networks underpinning the trade are able to move quickly between species and countries. Key consuming countries – China and Vietnam – have no enforceable controls against illegally logged timber imports. CITES empowers these environmenTal invesTigaTion agenCy (eia) Parties as enforcement partners.