CURRICULUM VITAE Antonio Frontera, MD

May 17th 2019 Milan, Italy

Personal Information

Nationality: Italian

Spoken languages

Languages Degree of fluency (written) Degree of fluency (spoken)

Italian Mother tongue Mother tongue English Excellent Excellent French Good Good

1 Academic records

Academic Degree Class Subject Year Institution

Università Cattolica Usefulness of CARTO ™ Medicine and 110/110 cum laude Sacro Cuore. Rome, Italy merge module for AF 2006 Surgery ablation procedures

Phenotype – Genotype Università Cattolica 50/50 cum laude correlation in 2012 Sacro Cuore. Rome, Italy Hypertrophic .

University of Bordeaux. Advance Management of Registered in Bordeaux, Ph.D. On going Ventricular Sept 2015

Post-graduate career including current employment

Place of work Post held From - to

Policlinico Gemelli, Rome – Italy Cardiology resident March 2007 –August 2011 Director Prof. Filippo Crea

Policlinico S. Matteo, Pavia – Italy Fellow at inherited cardiovascular diseases center September 2011 – May 2012 Director Prof.ssa Eloisa Arbustini and Prof. Schwartz

Istituto S.Ambrogio, Milan – Italy Consultant cardiologist - Electrophysiology June 2012 -March 2013 Director Dr. Massimo Mantica

Bristol Heart Institute, Bristol – United Kingdom Electrophysiology Fellow April 2013 to October 2014 Lead EP phisician Dr. Glyn Thomas

Hôpital Lèvéque, Bordeaux – France Electrophysiology Fellow – PhD student November 2014 to February 2018 Prof. Michel Haïssaguerre

San Raffaele Hospital, Italy Consultant cardiologist - Electrophysiology February 2018 to current Dr. Paolo Della Bella

Previous training and experience in clinical cardiology and electrophysiology

2

February 2018 to current: I have been appointed as cardiology consultant in Electrophysiology at San Raffaele Hospital (director professor Paolo Della Bella). I am involved in the daily management of complex arrhythmias (VT Unit). I spend 3 days per week in the electrophysiology laboratory being involved as first operator in and ventricular ablation procedures. In the remaining time I do research in the electrophysiology field of atrial fibrillation and ventricular tachycardia (main area of interest is the EGM characterization).

November 2014 to February 2018: I have been awarded by the European Heart Rhythm Association (EHRA) of one-year research grant in electrophysiology to be spent at Hôpital Haut Levéque, Bordeaux (Director Prof. Haïssaguerre). I was involved in the clinical activity as well in research projects on sudden cardiac death, atrial fibrillation and ventricular tachycardia ablation procedures. Since September 2015, I am a Ph.D student at University of Bordeaux. Current projects are: 1) Exploring the role of the right ventricle in the setting of CRT. A working heart model setup study. 2) Novel discrimination algorithms in SVT/VT: improving ICD therapies. 3) Non invasive study of VF mechanisms. These projects are being developed at the LIRYC institute under the supervision of Prof. Bordachar and Prof. Haïssaguerre.

March 2013 to October 2014: I was employed at University Hospitals Bristol NHS Foundation trust as clinical fellow in electrophysiology. My work schedule was 4 days per week in the electrophysiology lab plus a morning of outpatient clinic. I completed my own operating lists in conventional EP and was independent in performing transeptal punctures as well as performing complex ablation in left atrium (AF and AT). I developed good experience of ablating paroxysmal and persistent AF. I had some experience of 1st operator VT ablation and considerable experience of controlling the 3D mapping systems in these cases. I was also involved in more than 200 ICD/PPM implants and CRT devices (although has been my focus in my post).

May 2012 – March 2013: I was employed at Ist.Clinico S.Ambrogio (Gruppo San Donato, Milan) as consultant in EP. I spent three days per week in the EP lab performing pacing procedures, simple EP procedure (right sided). During this post I managed an acute general cardiology ‘take’ and A&E on call rota. I therefore have good experience of managing unstable cardiac patients.

Sept 2011 – Apr 2012: I was clinical fellow at the inherited cardiac centre – under Prof. E. Arbustini – Pavia University in collaboration with Prof. Schwartz. There I gained cardio-genetic skills, performing as first operator > 500 transthoracic and 150 transoesophageals echocardiogram. I had chance to study (and scan) 200 HCM patients and their families as part of my speciality thesis in cardiology. I also gained experience of managing patients with Marfan syndrome, Loyes dietz and Ehlers-danlos syndromes. I was involved in the follow-up of patients with ARVD, idiopathic dilated cardiomyopathy, long QT and Brugada syndrome.

3 Jan 2011 – August 2011: I spent 8 months in the EP lab of my University (Sacred Heart, Rome, Italy) where I was trained in performing conventional EP studies and procedures like atrial flutter, AV node ablation and PM implantation.

Sept 2010 – December 2010: I spent this time in the cath lab of my University (Sacred Heart, Rome – Italy). I performed some coronary angiograms as first operator and I’ve been involved in more than 100 angioplasty as second operator.

March 2008 – August 2010: I worked as SpR in CCU and Cardiology wards at Policlinico Gemelli - Rome, an hospital with more than 1000 beds, where I was involved in treating end stage heart failure, acute coronary syndromes and arrhythmias.

Experience with (3D) mapping system

• Knowledge of the entire CARTO Suite (Biosense, Johnson&Johnson): CartoXP , Carto Sound ™ , CARTO version 3,4, 5 and current 6. I am confident with the paso double™ function, SCI CFAE maps in the context of AF mapping. • NAVX - PRECISION suite (ABBOTT). Excellent experience with HD Grid catheter in the setting of Ventricular Tachycardia. • Rhythmia™ (Boston Scientific) – mainly used on AT and VT. I have great confidence with this machine, being able to run alone the whole setup. • Non invasive mapping: knowledge of the Cardioinsight (Medtronic) - More than 100 cases (VT, VF and AF procedures).

IT Knowledge

• Knowledge of MAC OSx, Windows 95,98, 2000, NT, XP, Windows 7 & Vista • Knowledge of the entire Office package: Powerpoint, Excel, Access, Word. • Basic knowledge of SPSS and STATA (statistic software) • Knowledge of HTML – JAVA - PHP languages – great experience in building WEB pages as well application for Iphone, Ipad, Android. • Knowledge of Osirix , 3D anatomic reconstruction of aorta and great vessels of the heart.

4 Hobbies

Astronomy. I have a 80Mm refractor, 12” dobson telescope, and (for the portable use) a stabilized binocular 15x50 Canon. I like the visual observations but main interest is astrophotography. I like to pass my free time during summer taking pictures of the deep sky: Messier objects like M31, Andromeda Galaxy and the well known M53 galaxy. The setup is Canon 450D, EQ systrek scan and refractor 80 mm by Skywatcher.

Radiocontrolled modellism. I have more than 15 RC models : airplanes (glider, seaplanes, warbirds reproduction mustang and spitfires), drones, helycopter, sail ships, submarines. Most of these RC models are electric. Only few are powered by gasoline (nitro).

Ham radio. I am radioamateur since 2006 when I built up my first RF trasmitter on 88 Mhz. My main interest is the study of wave propagation at different wavelenght. Lambda ½ Lamba vs ¼ dipoles and their reflection in the troposphere on HF band. I am licensed by the Italian minister of telecommunication with the callsign IZ0JOJ. I also performed this license in England (callsign M0HKH) and in France (Callsign F4VQW). I like QRP and low power transmission in morse cose. I own 6 transceivers, 1 on VHF band, 5 on HF band, one home made.

App developer. I have great interest in medical application for daily use. I personally developed Cardiourgenze and Heart Emergency, apps available on Apple Store as well on Android market. I recently developed the app “EP Rounds” (available since May 2017), which is an application where cardiologist can exchange (and comment) interesting ECG and EGM traces.

Research Peer reviewed publications

1. Lead Extraction : a new effective tool to overcome fibrous binding sites. Dello Russo A, Biddau R, Pelargonio G, Casella M, Frontera A, Camporeale A, Bisceglia C, Forleo GB, Tondo C, Zecchi P, Bellocci F. Journal of Interventional Cardiac Electrophysiology 2009 Mar; 24(2):147-50

2. Cardiac Myxoma presenting with sensory neuropathy. Santangeli P, Pieroni M, Marzo F, Frontera A, Vitulano N, Luciani N, Bellocci F, Crea F. International Journal of Cardiology 2010 Aug 6; 143 (1): e14-6

3. Prevalence of J-Point Elevation in Sudden Arrhythmic Death Syndrome Families Serio A, Frontera A, Arbustini E. Journal of American College of Cardiology 2012 May

5 1;59(18):1659-60; 1660-1

4. Cardiac arrest in concomitant Wolff-Parkinson-White syndrome and early repolarization: is pathway ablation enough? Frontera A, Thomas G, Duncan E. Heart 2014 Apr;100(7):598-9.

5. Screening for atrial fibrillation in patients with obstructive sleep apnoea to reduce ischaemic . Frontera A, Wilson D, Thomas G, Duncan E. Int J Cardiol. 2014 Mar 15;172(2):297-8

6. A case of malignant arrhythmia in takotsubo Cardiomyopathy. Dadistar AG, Frontera A, Petersen M. Journal of 2014 Sep-Oct;47(5):690-1.

7. Prevalence and significance of early repolarization in patients presenting with syncope. Frontera A, Carpenter A, Ahmed G, Fasiolo M, Diab I, Cripps T, Thomas G, Duncan E. International Journal of Cardiology 2014 Sep;176(1):298-9

8. The association between ICD interventions and mortality is independent of their modality: clinical implications. Bencardino G, Di Monaco A, Rio T, Frontera A, Santangeli P, Leo M, Pelargonio G, Perna F, Narducci ML, Gabrielli F, Lanza GA, Bellocci F, Rebuzzi A, Crea F. Journal of Cardiovascular Electrophysiology 2014 Dec;25(12):1363-7

9. Catheter Ablation of Atrial Fibrillation in Patients with Left Ventricular Systolic Dysfunction: A Systematic Review and Meta-Analysis. Anselmino M, Matta M, D’ascenzo F, Bunch TJ, Shilling RJ, Hunter RJ, Pappone C, Neumann T, Noelker G, Fiala M, Bertaglia E, Frontera A, Duncan E, Nalliah C, Jais P, Weerasooriya R, Kalman JM, Gaita F. Circulation Arrhythmia and Electrophysiology. 2014 Sep 28.

10. New strategies for ventricular tachycardia and ablation. Hooks DA, Berte B, Yamashita S, Mahida S, Sellal JM, Aljefairi N, Frontera A, Derval N, Denis A, Hocini M, Haïssaguerre M, Jaïs P, Sacher F. Expert Rev Cardiovascular Therapy. 2015 Mar;13(3):263-76.

11. Implantable cardioverted defibrillators in octogenarians: clinical outcomes from a single center. Wilson DG, Ahmed N, Nolan R, Frontera A, Thomas G, Duncan ER. Indian Pacing

6 Electrophysiology Journal 2015 Apr 1;15(1):4-14.

12. Premature ventricular beats initiate recurrent ventricular fibrillation in early repolarization syndrome. Ahmed N, Frontera A, Duncan E, Thomas G. Journal of Arrhythmias 2015 Apr;31(2):114-5.

13. Clinical Predictors of Pacemaker Implantation in Patients with Syncope Receiving Implantable Loop Recorder with or without ECG Conduction Abnormalities. Ahmed N, Frontera A, Carpenter A, Cataldo S, Connolly GM, Fasiolo M, Cripps T, Thomas G, Diab I, Duncan ER. Pacing Clinical Electrophysiology 2015 Aug; 38(8):934-41.

14. Transcoronary Ethanol Ablation for Incessant Ventricular Tachycardia: a salvage technique when faced with left ventricular thrombus. Frontera A, TW Johnson, Thomas G, Duncan E. Netherland Heart Journal 2015 Sep 9

15. Atrial fibrillation and hypertrophic cardiomyopathy. Who to anticoagulate? Frontera A, Wilson D, Duncan E. Thomas G. Clinical Res Cardiology 2015 Oct;104(10):799-802.

16. Vagal atrial fibrillation: what is it and should we treat it? Carpenter A, Frontera A, Bond R, Duncan E, Thomas G. International Journal of Cardiology 2015 Dec 15;201:415-21.

17. Demographic and clinical characteristics to predict paroxysmal atrial fibrillation: insights from an implantable loop recorder population. Frontera A, Carpenter A, Ahmed N, Fasiolo M, Nelson M, Diab I, Cripps T, Thomas G, Duncan E. Pacing Clinical Electrophysiology 2015 Oct;38(10):1217-22

18. Characterization of the Left-Sided Substrate in Arrhythmogenic Right Ventricular Cardiomyopathy. Berte B, Denis A, Amraoui S, Yamashita S, Komatsu Y, Pillois X, Sacher F, Mahida S, Wielandts JY, Sellal JM, Frontera A, Al Jefairi N, Derval N, Montaudon M, Laurent F, Hocini M, Haïssaguerre M, Jaïs P, Cochet H. Circulation Arrhythmias and Electrophysiology 2015 Aug 26.

7 19. Atrioventricular reciprocating tachycardia mediated by twin AV nodes. Frontera A. Hooks DA, Haissaguerre M, Derval N. Journal American College of Cardiology Electrophysiology. Jan 2016

20. Catheter ablation of atrial fibrillation in patients with diabetes mellitus: a systematic review and meta-analysis. Anselmino M, Matta M, D'ascenzo F, Pappone C, Santinelli V, Bunch TJ, Neumann T, Schilling RJ, Hunter RJ, Noelker G, Fiala M, Frontera A, Thomas G, Katritsis D, Jais P, Weerasooriya R, Kalman JM, Gaita F. Europace 2015 Oct;17(10):1518-1525.

21. Smart-watches: a potential challenger to the implantable loop recorder? Carpenter A and Frontera A. Europace, 2016 Jun;18(6):791-3.

22. Performance of a specific algorithm to minimize right ventricular pacing: a multicenter study. Strik M, Defaye P, Eschalier R, Mondoly P, Frontera A, Ritter P, Haïssaguerre M, Ploux S, Ellenbogen KA, Bordachar P. Heart Rhythm. 2016 Feb 17.

23. Body Surface Mapping to Guide Atrial Fibrillation Ablation. Yamashita S, Shah AJ, Mahida S, Sellal JM, Berte B, Hooks D, Frontera A, Jefairi NA, Wielandts JY, Lim HS, Amraoui S, Denis A, Derval N, Sacher F, Cochet H, Hocini M, Jaïs P, Haïssaguerre M. Arrhythm Electrophysiol Rev. 2015 Dec;4(3):172-6.

24. Accuracy of the pacemaker-mediated tachycardia algorithm in Boston Scientific devices. Strik M, Frontera A. Eschalier R, Defaye P, Mondoly P, Ritter P, Haïssaguerre M, Ploux S, Bordachar P. Journal of Electrocardiology 2016 Apr 22.

25. Impact of new technologies and approaches for post- ventricular tachycardia ablation during long-term follow-up. Yamashita S, Cochet H, Sacher F, Mahida S, Berte B, Hooks D, Sellal JM, Al Jefairi N, Frontera A, Komatsu Y, Lim HS, Amraoui S, Denis A, Derval N, Sermesant M, Laurent F, Hocini M, Haïssaguerre M, Montaudon M, Jaïs P. Circulation Arrhythmia and Electrophysiology. 2016 Jul;9(7).

8

26. Triple-loop re-entrant atrial tachycardia originated after pulmonary vein isolation. Takigawa M, Denis A, Frontera A, Derval N, Sacher F, Jaïs P, Haïssaguerre M. Journal of Interventional Cardiac Electrophysiology. Oct 5 2016

27. Safety and mid-term outcome of catheter ablation of ventricular tachycardia in octogenarian. Frontera A, Panikker S, Breitenstein A, Bruno VD, Connolly GM, Wilson D, Rio T, Dhinoja M, Hussain W, Schilling RJ, Thomas G, Wong T, Hunter R, Sacher F, Jais P, Duncan E. Europace Nov 9, 2016

28. Catheter Ablation for Ventricular Tachycardia in Patients with Nonischemic Cardiomyopathy. Thompson N, Frontera A, Takigawa M, Cheniti G, Massoullie G, Cochet H, Denis A, Chaumeil A, Derval N, Hocini M, Haissaguerre M, Jais P, Sacher F. Cardiac Electrophysiol Clin. 2017 Mar;9(1):47-54

29. Multicenter Investigation of an ICD Algorithm to Detect Oversensing. Welte N, Strik M, Eschalier R, Mondoly P, Pascal Defaye, Frontera A, Ritter P, Haïssaguerre M, Ploux S, Ellenbogen K, Bordachar P. Heart Rhythm, Mar 18. pii: S1547-5271(17)30345

30. Myocardial wall thinning predicts transmural substrate in patients with scar-related ventricular tachycardia. Yamashita S, Sacher F, Hooks DA, Berte B, Sellal JM, Frontera A, Al Jefairi N, Komatsu Y, Amraoui S, Denis A, Derval N, Sermesant M, Laurent F, Montaudon M, Hocini M, Haïssaguerre M, Jaïs P, Cochet H. Heart Rhythm. 2017 Feb;14(2):155-163. doi: 10.1016/j.hrthm.2016.11.012.

31. Diagnostic yield of cardiovascular magnetic resonance in young-middle aged patients with high- grade AV block. Baritussio A, Ghosh Dastidar A, Frontera A, Ahmed N, De Garate E, Harries I, Diab I, Duncan E, Thomas G, Nisbet A, Bucciarelli-Ducci C. Int J Cardiology 2017 Oct 1;244:335-339. doi: 10.1016/j.ijcard.2017.06.080. Epub 2017 Jun 21.

32. The electrical circuit of a hemodynamically unstable and recurrent ventricular tachycardia diagnosed in 35 s with the Rhythmia mapping system. Takigawa M, Frontera A, Thompson N, Capellino S, Jaïs P, Sacher F.

9 Journal of Arrhythmias 2017 Oct;33(5):505-507. doi: 10.1016/j.joa.2017.06.002. Epub 2017 Aug 2.

33. Dual loop reentrant tachycardia with a combination of a localized reentry and a macro-reentry. Takigawa M, Frontera A, Martin R, Jaïs P, Haissaguerre M, Sacher F. Journal of cardiology cases. April 2017, in press.

34. Relationship between Fibrosis detected on Late Gadolinium-enhanced MRI and Reentrant Activity assessed with ECGI in Human Persistent Atrial Fibrillation". Cochet H, Berte B, Sellal JM, Frontera A, Al Jefairi N, Komatsu Y, Amraoui S, Denis A, Derval N, Sermesant M, Laurent F, Montaudon M, Hocini M, Haïssaguerre M, Jaïs P. JACC Electrophysiology 2017 Oct (In press).

35. Frontiers in non-invasive cardiac mapping: future implications for arrhythmia treatment. Frontera A, Cheniti G, Martin CA, Takigawa M, Duchateau J, Puyo S, Martin R, Thompson N, Kitamura T, Vlachos K, Wolf M, Al-Jefairi N, Massoullié G, Pambrun T, Denis A, Sacher F, Derval N, Dubois R, Jaïs P, Hocini M, Haissaguerre M. Minerva Cardioangiol. 2017 Jul 12. doi: 10.23736/S0026-4725.17.04463-2

36. Atrial : Cause or effect with ablation of persistent atrial fibrillation? Yamashita S, Hooks DA, Shah A, Relan J, Cheniti G, Kitamura T, Berte B, Mahida S, Sellal JM, Jefairi NA, Frontera A, Amraoui S, Collotand F, Denis A, Derval N, Sacher F, Cochet H, Dubois R, Hocini M, Haïssaguerre M, Klein G, Jaïs P. J Cardiovasc Electrophysiology. 2017 Oct 26. doi: 10.1111/jce.13377

37. Revisiting anatomic macroreentrant tachycardia after atrial fibrillation ablation using ultrahigh- resolution mapping: Implications for ablation. Takigawa M, Derval N, Frontera A, Martin R, Yamashita S, Cheniti G, Vlachos K, Thompson N, Kitamura T, Wolf M, Massoullie G, Martin C, Al-Jefairi N, Amraoui S, Duchateau J, Klotz N, Pambrun T, Denis A, Sacher F, Cochet H, Meleze H, Haïssaguerre M, Jais P. Heart Rhythm 2017 Nov 22. pii: S1547-5271(17)31243-2. doi: 10.1016/j.hrthm.2017.10.029. [Epub ahead of print]

38. Arrhythmogenic response to isoproterenol testing vs. exercise testing in arrhythmogenic right ventricular cardiomyopathy patients. Denis A, Sacher F, Derval N, Martin R, Lim HS, Pambrun T, Massoullie G, Duchateau J, Cochet H, Pillois X, Cheniti G, Frontera A, Takigawa M, Vlachos K, Martin C, Kitamura T, Hocini M, Douard H, Jaïs P, Haïssaguerre M. Europace. 2018 Feb 1.

10 39. Universal ventricular coordinates: A generic framework for describing position within the heart and transferring data. Bayer J, Prassl AJ, Pashaei A, Gomez JF, Frontera A, Neic A, Plank G, Vigmond EJ. Med Image Anal. 2018 Feb 1;45:83-93. doi: 10.1016/j.media.2018.01.005

40. Characteristics of Single-Loop Macroreentrant Biatrial Tachycardia Diagnosed by Ultrahigh- Resolution Mapping System. Kitamura T, Martin R, Denis A, Takigawa M, Duparc A, Rollin A, Frontera A, Thompson N, Massoullié G, Cheniti G, Wolf M, Vlachos K, Martin CA, Al Jefairi N, Duchateau J, Klotz N, Pambrun T, Sacher F, Cochet H, Hocini M, Haïssaguerre M, Maury P, Jaïs P, Derval N. Circ Arrhythm Electrophysiology 2018 Feb;11(2):e005558. doi: 10.1161/CIRCEP.117.005558.

41. Long-Term Outcome of Substrate Modification in Ablation of Post-Myocardial Infarction Ventricular Tachycardia. Wolf M, Sacher F, Cochet H, Kitamura T, Takigawa M, Yamashita S, Vlachos K, Cheniti G, Frontera A, Martin R, Thompson N, Massoullié G, Lam A, Martin C, Collot F, Duchateau J, Pambrun T, Denis A, Derval N, Hocini M, Haïssaguerre M, Jaïs P. Circ Arrhythm Electrophysiology 2018 Feb;11(2):e005635. doi: 10.1161/CIRCEP.117.005635.

42. Relationship Between Fibrosis Detected on Late Gadolinium-Enhanced Cardiac Magnetic Resonance and Re-Entrant Activity Assessed With Electrocardiographic Imaging in Human Persistent Atrial Fibrillation. Cochet H, Dubois R, Yamashita S, Al Jefairi N, Berte B, Sellal JM, Hooks D, Frontera A, Amraoui S, Zemoura A, Denis A, Derval N, Sacher F, Corneloup O, Latrabe V, Clément-Guinaudeau S, Relan J, Zahid S, Boyle PM, Trayanova NA, Bernus O, Montaudon M, Laurent F, Hocini M, Haïssaguerre M, Jaïs P. JACC Clin Electrophysiol. 2018 Jan;4(1):17-29. doi: 10.1016/j.jacep.2017.07.019. Epub 2017 Nov 6.

43. Influence of contact force on voltage mapping: A combined magnetic resonance imaging and electroanatomic mapping study in patients with tetralogy of Fallot. Teijeira-Fernandez E, Cochet H, Bourier F, Takigawa M, Cheniti G, Thompson N, Frontera A, Camaioni C, Massouille G, Jalal Z, Derval N, Iriart X, Denis A, Hocini M, Haissaguerre M, Jais P, Thambo JB, Sacher F. Heart Rhythm. 2018 Mar 20. pii: S1547-5271(18)30236-4. doi: 10.1016/j.hrthm.2018.03.022.

44. Transient under-sensing of the ventricular lead during abdominal ultrasound as cause of ventricular fibrillation.

11 Frontera A, Klotz N, Martin R, Ploux S, Haīssaguerre M, Ritter P, Bordachar P. Pacing Clin Electrophysiol. 2018 May 7. doi: 10.1111/pace.13362. [Epub ahead of print]

45. Comprehensive Multicenter Study of the Common Isthmus in Post-Atrial Fibrillation Ablation Multiple-Loop Atrial Tachycardia. Takigawa M, Derval N, Maury P, Martin R, Denis A, Miyazaki S, Yamashita S, Frontera A, Vlachos K, Kitamura T, Cheniti G, Massoullieé G, Thompson N, Martin CA, Wolf M, Pillois X, Duchateau J, Klotz N, Duparc A, Rollin A, Pambrun T, Sacher F, Cochet H, Hocini M, Haiïssaguerre M, Jaiïs P. Circ Arrhythm Electrophysiol. 2018 Jun;11(6):e006019. doi: 10.1161/CIRCEP.117.006019.

46. First clinical use of novel ablation catheter incorporating local impedance data. Martin C, Martin R, Gajendragadkar P, Maury P, Takigawa M, Cheniti G, Frontera A, Kitamura T, Duchateau J, Vlachos K, Bourier F, Lam A, Lord S, Murray S, Shephard E, Pambrun T, Denis A, Derval N, Hocini M, Haissaguerre M, Jais P, Sacher F. J Cardiovasc Electrophysiol. 2018 Jun 2. doi: 10.1111/jce.13654. [Epub ahead of print]

47. Atrial tachycardia originating from deep septum following catheter ablation for persistent atrial fibrillation. Kitamura T, Martin R, Frontera A, Jaïs P. Europace. 2018 Apr 17. doi: 10.1093/europace/euy060. [Epub ahead of print] No abstract available.

48. Response to cardiac resynchronization therapy is determined by intrinsic electrical substrate rather than by its modification. Strik M, Ploux S, Huntjens PR, Nguyên UC, Frontera A, Eschalier R, Dubois R, Ritter P, Klotz N, Vernooy K, Haïssaguerre M, Crijns HJGM, Prinzen FW, Bordachar P. Int J Cardiol. 2018 Jun 6. pii: S0167-5273(18)30192-X. doi: 10.1016/j.ijcard.2018.06.005.

49. Importance of bipolar electrode orientation on local electrogram properties. Takigawa M, Relan J, Martin R, Kim S, Kitamura T, Frontera A, Cheniti G, Vlachos K, Massoullié G, Martin CA, Thompson N, Wolf M, Bourier F, Lam A, Duchateau J, Klotz N, Pambrun T, Denis A, Derval N, Magat J, Naulin J, Merle M, Collot F, Quesson B, Cochet H, Hocini M, Haïssaguerre M, Sacher F, Jaïs P. Heart Rhythm. 2018 Jul 17. pii: S1547- 5271(18)30697-0. doi: 10.1016/j.hrthm.2018.07.020.

50. High-power short-duration versus standard radiofrequency ablation: Insights on lesion metrics. Bourier F, Duchateau J, Vlachos K, Lam A, Martin CA, Takigawa M, Kitamura T, Frontera A, Cheniti G, Pambrun T, Klotz N, Denis A, Derval N, Cochet H, Sacher F, Hocini M, Haïssaguerre

12 M, Jais P. J Cardiovasc Electrophysiol. 2018 Aug 31. doi: 10.1111/jce.13724. [Epub ahead of print]

51. High-density characterization of a localized reentry circuit occurred after AF ablation. Frontera A, Takigawa M, Haïssaguerre M, Derval N, Jaïs P. Pacing Clin Electrophysiol. 2018 Sep 18. doi: 10.1111/pace.13497. [Epub ahead of print]

52. Chronic Total Coronary Occlusion and Ventricular Tachycardia: Not Just an Electrophysiology Business? Della Bella P, Frontera A. JACC Clin Electrophysiol. 2018 Sep;4(9):1224-1226. doi: 10.1016/j.jacep.2018.07.005. No abstract available.

53. Mapping and Ablation of Idiopathic Ventricular Fibrillation. Cheniti G, Vlachos K, Meo M, Puyo S, Thompson N, Denis A, Duchateau J, Takigawa M, Martin C, Frontera A, Kitamura T, Lam A, Bourier F, Klotz N, Derval N, Sacher F, Jais P, Dubois R, Hocini M, Haissaguerre M. Front Cardiovasc Med. 2018 Sep 18;5:123. doi: 10.3389/fcvm.2018.00123. eCollection 2018. Review.

54. Targeted ablation of specific electrogram patterns in low voltage areas after pulmonary vein antral isolation in persistent atrial fibrillation: Termination to an organized rhythm reduces atrial fibrillation recurrence. Efremidis M, Vlachos K, Letsas KP, Bazoukis G, Martin R, Frontera A, Asvestas D, Saplaouras A, Kitamura Τ, Georgopoulos S, Valkanas K, Karamichalakis N, Takigawa M, Sideris A, Derval N, Sacher F, Jais P. J Cardiovasc Electrophysiol. 2018 Oct 4. doi: 10.1111/jce.13763

55. Detailed comparison between wall thickness and voltages in chronic myocardial infarction. Takigawa M, Martin R, Cheniti G, Kitamura T, Vlachos K, Frontera A, Martin CA, Bourier F, Lam A, Pillois X, Duchateau J, Klotz N, Pambrun T, Denis A, Derval N, Hocini M, Haïssaguerre M, Sacher F, Jaïs P, Cochet H.

56. Characterizing localised reentry with high resolution mapping: evidence for multiple slow conducting isthmuses within the circuit. Frontera A, Mahajan R, Dallet C, Vlachos K, Kitamura T, Cheniti G, Takigawa M, Martin C, Duchateau J, Lam A, Bourier F, Pambrun T, Hocini M, Sacher F, Denis A, Derval N, Haïssaguerre M, Dubois R, Jaïs P. Heart Rhythm. 2018 Nov 27. pii: S1547-5271(18)31172-X

13 57. Characteristics of Scar-Related Ventricular Tachycardia Circuits Using Ultra-High-Density Mapping. Martin R, Maury P, Bisceglia C, Wong T, Estner H, Meyer C, Dallet C, Martin CA, Shi R, Takigawa M, Rollin A, Frontera A, Thompson N, Kitamura T, Vlachos K, Wolf M, Cheniti G, Duchâteau J, Massoulié G, Pambrun T, Denis A, Derval N, Hocini M, Della Bella P, Haïssaguerre M, Jaïs P, Dubois R, Sacher F. Circ Arrhythm Electrophysiol. 2018 Oct;11(10):e006569. doi: 10.1161/CIRCEP.118.006569.

58. A simple mechanism underlying the behavior of reentrant atrial tachycardia during ablation. Takigawa M, Derval N, Martin CA, Vlachos K, Denis A, Kitamura T, Cheniti G, Bourier F, Lam A, Martin R, Frontera A, Thompson N, Massoullié G, Wolf M, Duchateau J, Klotz N, Pambrun T, Sacher F, Cochet H, Hocini M, Haïssaguerre M, Jaïs P. Heart Rhythm. 2018 Oct 30. pii: S1547-5271(18)31117-2. doi: 10.1016/j.hrthm.2018.10.031.

59. Depolarization versus repolarization abnormality underlying inferolateral J wave syndromes - new concepts in sudden cardiac death with apparently normal hearts. Haïssaguerre M, Nademanee K, Hocini M, Cheniti G, Duchateau J, Frontera A, Sacher F, Derval N, Denis A, Pambrun T, Dubois R, Jaïs P, Benoist D, Walton RD, Nogami A, Coronel R, Potse M, Bernus O. Heart Rhythm. 2018 Nov 1. pii: S1547-5271(18)31130-5. doi: 10.1016/j.hrthm.2018.10.040

60. Atrial Fibrillation Mechanisms and Implications for Catheter Ablation. Cheniti G, Vlachos K, Pambrun T, Hooks D, Frontera A, Takigawa M, Bourier F, Kitamura T, Lam A, Martin C, Dumas-Pommier C, Puyo S, Pillois X, Duchateau J, Klotz N, Denis A, Derval N, Jais P, Cochet H, Hocini M, Haissaguerre M, Sacher F. Front Physiol. 2018 Oct 17;9:1458. doi: 10.3389/Fphys.2018.01458.

61. Early Repolarization Syndrome: Diagnostic and Therapeutic Approach. Bourier F, Denis A, Cheniti G, Lam A, Vlachos K, Takigawa M, Kitamura T, Frontera A, Duchateau J, Pambrun T, Klotz N, Derval N, Sacher F, Jais P, Haissaguerre M, Hocini M. Front Cardiovasc Med. 2018 Nov 27;5:169. doi: 10.3389/fcvm.2018.00169. eCollection 2018. Review.

62. Detailed Analysis of the Relation Between Bipolar Electrode Spacing and Far- and Near-Field Electrograms. Takigawa M, Relan J, Martin R, Kim S, Kitamura T, Cheniti G, Vlachos K, Pillois X, Frontera A, Massoullié G, Thompson N, Martin CA, Bourier F, Lam A, Wolf M, Duchateau J, Klotz N, Pambrun T, Denis A, Derval N, Magat J, Naulin J, Merle M, Collot F, Quesson B,

14 Cochet H, Hocini M, Haïssaguerre M, Sacher F, Jaïs P.JACC Clin Electrophysiol. 2019 Jan;5(1):66-77. doi: 10.1016/j.jacep.2018.08.022. Epub 2018 Nov 1

63. Is it feasible to offer 'targeted ablation' of ventricular tachycardia circuits with better understanding of isthmus anatomy and conduction characteristics? Bourier F, Martin R, Martin CA, Takigawa M, Kitamura T, Frontera A, Cheniti G, Lam A, Vlachos K, Duchateau J, Pambrun T, Derval N, Denis A, Klotz N, Hocini M, Haïssaguerre M, Jaïs P, Cochet H, Sacher F. Europace. 2019 Jan 1;21(Supplement_1):i27-i33. doi: 10.1093/europace/euy173.

64. Fast and safe mapping of ventricular tachycardia in patient with left ventricular assist device. Trevisi N, Frontera A, Calore F, Okubo K, Della Bella P. Clin Case Rep. 2019 Feb 19;7(4):630- 631. doi: 10.1002/ccr3.2004. eCollection 2019 Apr.

65. Use of Novel Electrogram "Lumipoint" Algorithm to Detect Critical Isthmus and Abnormal Potentials for Ablation in Ventricular Tachycardia. Martin CA, Takigawa M, Martin R, Maury P, Meyer C, Wong T, Shi R, Gajendragadkar P, Frontera A, Cheniti G, Thompson N, Kitamura T, Vlachos K, Wolf M, Bourier F, Lam A, Duchâteau J, Massoullié G, Pambrun T, Denis A, Derval N, Hocini M, Haïssaguerre M, Jaïs P, Sacher F. JACC Clin Electrophysiol. 2019 Apr;5(4):470-479.

66. Insights from atrial surface activation throughout atrial tachycardia cycle length: A new mapping tool. Takigawa M, Martin CA, Derval N, Denis A, Vlachos K, Kitamura T, Frontera A, Martin R, Cheniti G, Lam A, Bourier F, Thompson N, Wolf M, Massoullie G, Escande W, Andre C, Zeng LJ, Nakatani Y, Roux JR, Duchateau J, Pambrun T, Sacher F, Cochet H, Hocini M, Haissaguerre M, Jais P. Heart Rhythm. 2019 Apr 17. pii: S1547-5271(19)30358-3.

67. Impairment of the antegrade fast pathway in patients with atrioventricular nodal reentrant tachycardia can be functional and treated by slow pathway ablation: a case report study. Cheniti G, Glover BM, Frontera A, Denis A, Haissaguerre M, Derval N. Eur Heart J Case Rep. 2018 Jul 13;2(3)

68. Long-Term Follow-Up of Idiopathic Ventricular Fibrillation in a Pediatric Population: Clinical Characteristics, Management, and Complications. Frontera A, Vlachos K, Kitamura T, Mahida S, Pillois X, Fahy G, Marquie C, Cappato R, Stuart G, Defaye P, Kaski JP, Ector J, Maltret A, Scanu P, Pasquie JL, Deisenhofer I, Blankoff I, Scherr D, Manninger M, Aizawa Y, Koutbi L, Denis A, Pambrun T, Ritter P, Sacher F, Hocini M, Maury P, Jaïs P, Bordachar P, Haïssaguerre M, Derval N. J Am Heart Assoc. 2019 May 7;8(9):e011172. doi: 10.1161/J

15 69. Electrogram signature of specific activation patterns: Analysis of atrial tachycardias at high-density endocardial mapping. Frontera A, Takigawa M, Martin R, Thompson N, Cheniti G, Massoullié G, Duchateau J, Wielandts JY, Teijeira E, Kitamura T, Wolf M, Al-Jefairi N, Vlachos K, Yamashita S, Amraoui S, Denis A, Hocini M, Cochet H, Sacher F, Jaïs P, Haïssaguerre M, Derval N. Heart Rhythm. 2018 Jan;15(1):28-37. doi: 10.1016/j.hrth

Books

Ablation for Atrial Fibrillation - N.Thompson, A.Frontera, M.Takigawa, Nicolas Derval, Arnaud Denis, Meleze Hocini, Michel Haïssaguerre - Book: Catheter ablation of arrhythmias – Editor Douglas ZIPES (ELSEVIER) 2016.

Therapy of J wave syndromes – A.Frontera, Michael E. Field,, Arnaud Denis,, Nicolas Derval, Caroline Thambo, Pierre Jais, Meleze Hocini, Michel Haïssaguerre, Frederic Sacher. Book: J wave syndromes – Editor Charles Antzelevitch (ELSEVIER) 2016

International meetings

Speaker and poster presentation at :

• Heart Rhythm Society 2014, San Francisco. Poster presentation on Early repolarization and syncope. What’s the clinical significance?

• Heart Rhythm Society 2015, Boston. Speaker / Poster presentation Boston. Safety and outcome of Ventricular tachycardia RF ablation in octogenarians

• Heart Rhythm Society 2016, San Francisco. Speaker / Poster presentation 1) Idiopathic ventricular fibrillation in the pediatric age 2) Pacemaker mediated tachycardia & RHYTHMIQ function in Boston scientific pacemakers 3) Intramyocardial fat in the left atrium detected with CT-

16 MD.

• Heart Rhythm Society 2017, Chicago. Speaker / poster presentation: 1) EGM fractionation in apparently healthy tissue: time to redefine the voltage threshold for diseased atrium? 2) Relationship between scar and AT mechanisms: insight from registered magnetic resonance and HD activation mapping

• Heart Rhythm Society 2018, Boston: Speaker : 1) Real-life assessment of morphology-based algorithms for arrhythmias discrimination by ICDs: a multicenter study. 2) Sudden death in young adults. Insights from a 6-year national study. 3) Characterizing localised reentry with high density mapping: evidence for multiple slow conducting isthmuses within the circuit.

• ESC 2016, Rome. Poster on “Electrogram characteristics of specific substrate mechanisms during atrial tachycardia with high-density mapping”.

• EHRA/CARDIOSTIM 2017, Prague. Speaker / poster presentation: 1) Characterization of re- entrant atrial tachycardia circuits with a HD mapping. 2) Relationship of voltage and EGM duration at sites of fractionation during AT and paced rhythms. 3) Characterization of slow conductions areas in scar-related AT. Insights from HD mapping system

• Meeting sulla morte improvvisa. Giugno 2017. Piacenza (Dr. Aschieri). Speaker on “ Early repolarization, what we know?”

• Luci ed ombre in aritmologia. Set 2017. Pisa (Prof. Bongiorni). Speaker on “Cardioinsight. A novel non-invasive mapping system to guide ablation of complex arrhythmias”.

• Place 2017 – Rome. Speaker on “EGM fractionation, when, where and why it occurs” - “Idiopathic VF in children. Insights from a multicenter international registry”.

AWARDS

2014 year. EHRA research Award - One-year research grant in electrophysiology to be spent at Hôpital Haut Levéque, Bordeaux, France (Prof. Michel Haissaguerre and Prof. Pierre Jais).

2016 June. EHRA Certified Electrophysiology Specialist levels (ECES level 1 & 2) for electrophysiology.

2016 August. Best poster in catheter ablation at the ESC conference in Rome. Poster title “Electrogram characteristics of specific substrate mechanisms during atrial tachycardia with high-density mapping”.

2018 May – HRS Boston. Finalist at Young Investigator Award with the work “Characterizing localised re- entry with high density mapping: evidence for multiple slow conducting isthmuses within the circuit”.

17 2018 October – Pitagora Prize - Città di Crotone for the best scientific CV.

Milan, May 17th 2019

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