International Journal of Plant, Animal and Environmental Sciences DOI: 10.26502/ijpaes.002 Research Article Comparison of The Anti-Inflammatory and Immunomodulatory Mechanisms of Two Medicinal Herbs: Meadowsweet (Filipendula ulmaria) and Harpagophytum (Harpagophytum procumbens) Juliette Cholet1*, Caroline Decombat1†, Marjolaine Vareille-Delarbre1,† , Maël Gainche2, Alexandre Berry1, Clémence Ogéron2, Isabelle Ripoche2, Laetitia Delort1, Marion Vermerie1, Didier Fraisse1, Catherine Felgines1, Edwige Ranouille3, Jean-Yves Berthon3, Albert Tourette4, Yves Troin2, François Senejoux1, Pierre Chalard2, Florence Caldefie-Chezet1 1Université Clermont Auvergne, INRA, UNH, Unité de Nutrition Humaine, CRNH Auvergne, F-63000, Clermont-Ferrand, France 2Université Clermont Auvergne, CNRS, SIGMA Clermont, ICCF, F-63000 Clermont-Ferrand, France 3Greentech, Biopôle Clermont-Limagne, 63360 Saint-Beauzire, France 4AltoPhyto, 7 rue des gargailles, 63370 Lempdes, France †Equal contributions *Corresponding Author: Juliette Cholet, Université Clermont Auvergne, INRA, UNH, Unité de Nutrition Humaine, CRNH Auvergne, F-63000, Clermont-Ferrand, France, Tel: +33-4-73-17-79-72; E-mail:
[email protected] Received: 24 June 2019; Accepted: 10 July 2019; Published: 22 July 2019 Abstract Background: Meadowsweet (Filipendula ulmaria) and Harpagophytum (H. procumbens) are two medicinal herbs traditionally used for their anti-inflammatory effect. Nonetheless, if the effects of the single compounds isolated from these plants have been well described, little is known about the molecular mechanisms behind whole extracts. Methods: We studied and compared the effects of methanolic extracts from the aerial parts of F. ulmaria (FUE) and from the roots of H. procumbens (HPE) on different markers of inflammation such as antioxidant capacity, leukocyte ROS production, COX-2/PGE2 pathway or cytokine secretions. Results: FUE proved to be better than HPE in terms of antioxidant capabilities.