DOCSLIB.ORG

Evidence That Dimethyl Sulfide Facilitates a Tritrophic Mutualism Between Marine Primary Producers and Top Predators

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Evidence That Dimethyl Sulfide Facilitates a Tritrophic Mutualism Between Marine Primary Producers and Top Predators Evidence that dimethyl sulfide facilitates a tritrophic mutualism between marine primary producers and top predators Matthew S. Savocaa,b and Gabrielle A. Nevitta,b,1 aGraduate Group in Ecology, University of California, Davis, CA 95616; and bDepartment of Neurobiology, Physiology, and Behavior, College of Biological Sciences, University of California, Davis, CA 95616 Edited by May R. Berenbaum, University of Illinois at Urbana–Champaign, Urbana, IL, and approved February 3, 2014 (received for review September 10, 2013) Tritrophic mutualistic interactions have been best studied in plant– in this regard, and many species have been shown to detect and insect systems. During these interactions, plants release volatiles respond to biogenic concentrations of DMS in foraging contexts in response to herbivore damage, which, in turn, facilitates pre- (24, 25). Members of this order share highly pelagic lifestyles and dation on primary consumers or benefits the primary producer by are central-place foragers associated with land only during in- providing nutrients. Here we explore a similar interaction in the cubation and chick rearing (26). Procellariiformes routinely range Southern Ocean food web, where soluble iron limits primary pro- thousands of kilometers to forage (27) and have large olfactory ductivity. Dimethyl sulfide has been studied in the context of bulbs compared with other avian clades (28), and some species global climate regulation and is an established foraging cue for marine top predators. We present evidence that procellariiform have been shown to track their prey using their sense of smell (29). seabird species that use dimethyl sulfide as a foraging cue selec- Some procellariiform species are attracted to DMS, whereas others tively forage on phytoplankton grazers. Their contribution of ben- are not (24, 30) (Fig. 1); however, the relationship between DMS eficial iron recycled to marine phytoplankton via excretion suggests behavioral sensitivity and the consumption of herbivorous crusta- a chemically mediated link between marine top predators and oce- cea has not previously been shown. anic primary production. The Southern Ocean is the largest marine ecosystem in the world, with the polar front forming a distinct northern boundary any plant species interact with carnivores to gain pro- to this ecoregion (31). Our rationale for using this system is Mtection from herbivory. Such mutualistic tritrophic inter- twofold: (i) A majority of the world’s procellariiform species actions have been studied extensively in plant–insect systems, breed or forage in the Southern Ocean (32), and (ii) food web and are frequently mediated by plant volatiles released in re- relationships are relatively simple by comparison with other sponse to insect feeding (1). One example that has received marine systems. Phaeocystis antarctica and several siliceous di- detailed study is the interaction between the phytophagous two- atom species are the dominant DMS-producing phytoplankton Tetranychus urticae spotted spider mite , the lima bean plant species in this ecosystem, and Antarctic krill (Euphasia superba) Phaseolus lunatus, and the predatory mite Phytoseiulus persimilis and other small crustaceans (copepods, decapods, amphipods, (2, 3). In this model system, grazing by the herbivorous spider mite has been demonstrated to elicit a cascade of biochemical etc.) are their major consumers. reactions within the afflicted plants, stimulating the release of Here we take advantage of a 50-y dietary database of Southern a suite of volatile terpenoids such as (E)-4,8-dimethyl-l,3, Ocean seabirds (33) to explore whether DMS mediates a mutual- 7-nonatriene, (E)-β-ocimene, and (E,E)-4,8,12-trimethyl-1,3,7, istic tritrophic interaction in the Southern Ocean pelagic ecosys- 11-tridecatetraene (3). These volatiles attract olfactory-searching tem. If this is the case, then we predict that (i) carnivorous species, P. persimilis that prey upon herbivorous spider mites. such as seabirds, that are attracted to this infochemical should spe- The possibility of tritrophic mutualisms involving plant vola- cialize on primary consumers, such as crustaceans, and (ii)primary tiles has received considerable attention in terrestrial commu- producers should gain some benefit from this interaction. nities (2–5); however, similar interactions have rarely been suggested for marine systems (6). Dimethyl sulfide (DMS) and its Significance precursor dimethylsulfoniopropionate (DMSP) are well-established infochemicals in the marine environment, and as such are good This study demonstrates that dimethyl sulfide, a chemical cue candidate molecules for mediating tritrophic interactions between involved in global climate regulation, mediates a tritrophic phytoplankton and carnivores (7–10). DMS arises as a catabolic mutualistic interaction between marine apex predators and breakdown product of DMSP, and has been studied extensively primary producers. Our results imply that marine top predators for its putative role as a global climate regulator (11). DMSP is play a critical role in maintaining both ocean health and global produced by marine algae, where it has been proposed to function climate. Our results highlight the need for more collaboration as an osmolyte (12) and a cryoprotectant (13). When algal cells and discussion between micro- and macroscale biologists lyse, due to biotic or abiotic stress, one of the fates of DMSP is working on global issues in the Southern Ocean. catabolism by the enzyme DMSP lyase to DMS and acrylic acid – (14 16). This process may also occur during autocatalytic cell Author contributions: M.S.S. and G.A.N. designed research; G.A.N. developed the initial death (17). It has been proposed that acrylic acid is the bi- dataset; M.S.S. performed research; M.S.S. analyzed data; and M.S.S. and G.A.N. wrote ologically salient product of this reaction due to its antimicrobial the paper. properties (18). Conflict of interest statement: The authors declare a conflict of interest (such as defined DMS production has also been shown to increase during by PNAS policy). zooplankton grazing (14). It has been previously proposed that This article is a PNAS Direct Submission. this phytoplankton-derived odorant is an important infochemical Freely available online through the PNAS open access option. 1 for marine apex predators including whale sharks (19), harbor To whom correspondence should be addressed. E-mail: [email protected]. ECOLOGY – seals (20), penguins (21 23), and procellariiform (tube-nosed) This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10. seabirds (24). Procellariiform seabirds have been the best-studied 1073/pnas.1317120111/-/DCSupplemental. www.pnas.org/cgi/doi/10.1073/pnas.1317120111 PNAS | March 18, 2014 | vol. 111 | no. 11 | 4157–4161 Downloaded by guest on September 25, 2021 Procellariiform species included in analysis alopods in the diet showed a positive overall relationship (Fig. 3B), but log-transformed weight was the only significant mor- Sphenisciformes phological predictor (βlog wt = 0.12 ± 0.055, P = 0.03; βDMS tracker = Oceanites oceanicus Hydrobatidae −0.10 ± 0.082, P = 0.23 and βaspect ratio = 0.06 ± 0.016, P = Fregetta tropica β = − ± P = Thalassarche melanophris 0.89; DMS tracker 0.03 0.076, 0.70). The multiple linear Thalassarche chrysostoma Diomedeidae regression for the proportion of fish in the diet exhibited Diomedea exulans a weakly positive overall relationship (Fig. 3C), but neither Pelecanoides urinatrix Pelecaniodidae morphological parameter was significant (βlog wt = 0.01 ± 0.049, Pagodroma nivea P = 0.89; βDMS tracker = −0.15 ± 0.073, P = 0.04 and βaspect ratio = Thalassoica antarctica 0.02 ± 0.015, P = 0.29; βDMS tracker = −0.10 ± 0.070, P = 0.16; Fig. Daption capense 3C). Taken together, these results suggest that DMS behavioral Macronectes halli Macronectes giganteus responsiveness is linked to the consumption of primary con- Fulmarus glacialoides sumers (crustacea) that forage on DMS-producing phytoplank- Pachyptila turtur Procellariidae ton. As a result, we argue that procellariiform seabirds are Pachyptila desolata playing a similar role to that played by carnivorous mutualists Pachyptila salvini (e.g., P. persimilis) in plant–insect interactions. outgroup Pachyptila belcheri For this chemically mediated, tritrophic interaction to be mu- DMS + Halobaena caerulea tualistic, it must also carry a benefit to phytoplankton (Fig. 4). Procellaria aequinoctialis DMS − Predatory release implies that phytoplankton are “rescued” from Fig. 1. Phylogenetic relationships between the species included in the meta- grazing pressure when primary consumers are ingested by car- analysis, mapped with DMS responsiveness. DMS responsiveness is thought to nivores. Our results support this hypothesis in that DMS res- be ancestral in this lineage (30). Certain species in the outgroup, sphenisci- ponders were found to preferentially consume phytoplankton formes (penguins), have also been shown to be responsive to DMS (21–23). grazers (Fig. 2). However, we also considered the possible fer- tilization benefits that foraging seabirds may provide to phyto- plankton. Iron is necessary for electron transfer and ATP pro- Results duction involved in phytoplankton growth (36), but the Southern To address our first prediction, we conducted a meta-analysis of Ocean is iron-limited (37). This is because the Southern Ocean diet composition relative to DMS behavioral sensitivity for dif- lacks major land masses
Load more

Recommended publications
  • Anaerobic Degradation of Methanethiol in a Process for Liquefied Petroleum Gas (LPG) Biodesulfurization
    Anaerobic degradation of methanethiol in a process for Liquefied Petroleum Gas (LPG) biodesulfurization Promotoren Prof. dr. ir. A.J.H. Janssen Hoogleraar in de Biologische Gas- en waterreiniging Prof. dr. ir. A.J.M. Stams Persoonlijk hoogleraar bij het laboratorium voor Microbiologie Copromotor Prof. dr. ir. P.N.L. Lens Hoogleraar in de Milieubiotechnologie UNESCO-IHE, Delft Samenstelling promotiecommissie Prof. dr. ir. R.H. Wijffels Wageningen Universiteit, Nederland Dr. ir. G. Muyzer TU Delft, Nederland Dr. H.J.M. op den Camp Radboud Universiteit, Nijmegen, Nederland Prof. dr. ir. H. van Langenhove Universiteit Gent, België Dit onderzoek is uitgevoerd binnen de onderzoeksschool SENSE (Socio-Economic and Natural Sciences of the Environment) Anaerobic degradation of methanethiol in a process for Liquefied Petroleum Gas (LPG) biodesulfurization R.C. van Leerdam Proefschrift ter verkrijging van de graad van doctor op gezag van de rector magnificus van Wageningen Universiteit Prof. dr. M.J. Kropff in het openbaar te verdedigen op maandag 19 november 2007 des namiddags te vier uur in de Aula Van Leerdam, R.C., 2007. Anaerobic degradation of methanethiol in a process for Liquefied Petroleum Gas (LPG) biodesulfurization. PhD-thesis Wageningen University, Wageningen, The Netherlands – with references – with summaries in English and Dutch ISBN: 978-90-8504-787-2 Abstract Due to increasingly stringent environmental legislation car fuels have to be desulfurized to levels below 10 ppm in order to minimize negative effects on the environment as sulfur-containing emissions contribute to acid deposition (‘acid rain’) and to reduce the amount of particulates formed during the burning of the fuel. Moreover, low sulfur specifications are also needed to lengthen the lifetime of car exhaust catalysts.
    [Show full text]
  • University of Warwick Institutional Repository
    CORE Metadata, citation and similar papers at core.ac.uk Provided by Warwick Research Archives Portal Repository University of Warwick institutional repository: http://go.warwick.ac.uk/wrap This paper is made available online in accordance with publisher policies. Please scroll down to view the document itself. Please refer to the repository record for this item and our policy information available from the repository home page for further information. To see the final version of this paper please visit the publisher’s website. Access to the published version may require a subscription. Author(s): Hendrik Schäfer, Natalia Myronova and Rich Boden Article Title: Microbial degradation of dimethylsulphide and related C1- sulphur compounds: organisms and pathways controlling fluxes of sulphur in the biosphere Year of publication: 2010 Link to published version: http://dx.doi.org/ 10.1093/jxb/erp355 Publisher statement: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Journal of Experimental Botany following peer review. The definitive publisher-authenticated version Schäfer, H. et al. (2010). Microbial degradation of dimethylsulphide and related C1-sulphur compounds: organisms and pathways controlling fluxes of sulphur in the biosphere. Journal of Experimental Botany, Vol. 61(2), pp. 315-334 is available online at: http://jxb.oxfordjournals.org/cgi/content/full/61/2/315 Microbial degradation of dimethylsulfide and related C1-sulfur compounds: organisms and pathways controlling fluxes of sulfur in the biosphere Hendrik Schäfer*1, Natalia Myronova1, Rich Boden2 1 Warwick HRI, University of Warwick, Wellesbourne, CV35 9EF, UK 2 Biological Sciences, University of Warwick, Coventry, CV4 7AL, UK * corresponding author Warwick HRI University of Warwick Wellesbourne CV35 9EF Tel: +44 2476 575052 [email protected] For submission to: Journal of Experimental Botany 1 Abstract 2 Dimethylsulfide (DMS) plays a major role in the global sulfur cycle.
    [Show full text]
  • Kinetics of the Ozonation of Dimethyl Sulfide in the Gas Phase
    University of Montana ScholarWorks at University of Montana Graduate Student Theses, Dissertations, & Professional Papers Graduate School 1973 Kinetics of the ozonation of dimethyl sulfide in the gas phase Robert John Moody The University of Montana Follow this and additional works at: https://scholarworks.umt.edu/etd Let us know how access to this document benefits ou.y Recommended Citation Moody, Robert John, "Kinetics of the ozonation of dimethyl sulfide in the gas phase" (1973). Graduate Student Theses, Dissertations, & Professional Papers. 8125. https://scholarworks.umt.edu/etd/8125 This Thesis is brought to you for free and open access by the Graduate School at ScholarWorks at University of Montana. It has been accepted for inclusion in Graduate Student Theses, Dissertations, & Professional Papers by an authorized administrator of ScholarWorks at University of Montana. For more information, please contact [email protected]. KINETICS OF THE OZONATION OF DIMETHYL SOLFIDB IN THE GAS PHASE by Robert J, Moody B.S., University of Montana, 1968 Presented in partial fulfillment of the requirements for the degree of Master of Science UNIVERSITY OF MONTANA 1973 Approved by: Chairman, Board of Examiners Deanf 'Graduait Schoo Date 7 Reproduced with permission of the copyright owner. Further reproduction prohibited without permission. UMI Number: EP38926 All rights reserved INFORMATION TO ALL USERS The quality of this reproduction is dependent upon the quality of the copy submitted. In the unlikely event that the author did not send a complete manuscript and there are missing pages, these will be noted. Also, if material had to be removed, a note will indicate the deletion.
    [Show full text]
  • MSM) Levels in Human Plasma Ling Lin1,2*, Dejian Ma1, Richard J
    ition & F tr oo OPEN ACCESS Freely available online u d N f S o c l i e a n n c r e u s o J ISSN: 2155-9600 Journal of Nutrition & Food Sciences Research Article Development and Application of an LC-MS/MS Method for Determining Methylsulfonylmethane (MSM) levels in Human Plasma Ling Lin1,2*, Dejian Ma1, Richard J. Bloomer3, Matthew Butawan3 , Webb A. Smith4,5, Charles R. Yates6 1Department of Pharmaceutical Sciences, University of Tennessee College of Pharmacy, Memphis, TN, USA; 2Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China; 3Center for Nutraceutical and Dietary Supplement Research, School of Health Studies, University of Memphis, Memphis, TN, USA Savar; 4Department of Pediatrics, University of Tennessee College of Medicine, Memphis, TN, USA; 5Children’s Foundation Research Institute, LeBonheur Children’s Hospital, Memphis, TN, USA; 6The National Center for Natural Products Research, Oxford, MS, USA ABSTRACT Methylsulfonylmethane (MSM) isan organosulfur phytochemical widely used as a dietary supplement carrying structure/function claims that includethe promotion of joint health. Untargeted metabolomics studies using nuclear magnetic resonance (NMR) have identified MSM in plasma and urine. However, MS-based methodology is more suitable for pharmacokinetic studies designed to explore MSM’s concentration-effect relationship for purposes of establishing dosing guidelines. To address this deficiency, an LC-MS/MS method using MSM, deuterated MSM (MSM-d6, internal standard), and liquid-liquid extraction was developed and validated in accordance with international guidelines. The method proved well-suited for determining MSM levels in human plasma following chronic oral administration (1, 2, or 3 grams daily) for four weeks.
    [Show full text]
  • Dimethyl Sulfide-Dimethyl Ether and Ethylene Oxide-Ethylene Sulfide Complexes In- Vestigated by Fourier Transform Microwave Spectroscopy and Ab Initio Calculation
    DIMETHYL SULFIDE-DIMETHYL ETHER AND ETHYLENE OXIDE-ETHYLENE SULFIDE COMPLEXES IN- VESTIGATED BY FOURIER TRANSFORM MICROWAVE SPECTROSCOPY AND AB INITIO CALCULATION YOSHIYUKI KAWASHIMA, YOSHIO TATAMITANI, TAKAYUKI MASE, Applied Chemistry, Kanagawa Institute of Technology, Atsugi, Japan; EIZI HIROTA, The Central Office, The Graduate University for Ad- vanced Studies, Hayama, Kanagawa, Japan. The ground-state rotational spectra of the dimethyl sulfide-dimethyl ether (DMS-DME) and the ethylene oxide and ethylene sulfide (EO-ES) complexes were observed by Fourier transform microwave spectroscopy, and a-type and c-type transitions were assigned for the normal, 34S, and three 13C species of the DMS-DME and a-type and b-type rotational transitions for the normal, 34S, and two 13C species of the EO-ES. The observed transitions were analyzed by using an S-reduced asymmetric-top rotational Hamiltonian. The rotational parameters thus derived for the DMS-DME were found consistent with a structure of Cs symmetry with the DMS bound to the DME by two C-H(DMS)—O and one S—H- C(DME) hydrogen bonds. The barrier height V 3 to internal rotation of the ”free” methyl group in the DME was determined to be 915.4 (23) cm−1, which is smaller than that of the DME monomer, 951.72 (70) cm−1,a and larger than that of the DME dimer, 785.4 (52) cm−1.b For the EO-ES complex the observed data were interpreted in the terms of an antiparallel Cs geometry with the EO bound to the ES by two C-H(ES)—O and two S—H-C(EO) hydrogen bonds.
    [Show full text]
  • Long‐Term Trends for Marine Sulfur Aerosol in the Alaskan Arctic And
    Quinn Patricia, K. (Orcid ID: 0000-0003-0337-4895) Pratt Kerri, A. (Orcid ID: 0000-0003-4707-2290) Sheesley Rebecca, Jacobs (Orcid ID: 0000-0002-8187-0571) Long-term trends for marine sulfur aerosol in the Alaskan Arctic and relationships with temperature Claire E. Moffett1, Tate E. Barrett1,2*, Jun Liu3, Matthew J. Gunsch3†, Lucia Upchurch4, Patricia K. Quinn5, Kerri A. Pratt3, Rebecca J. Sheesley1,2 1Department of Environmental Science, Baylor University, Waco, TX, USA. 2The Institute of Ecological, Earth, and Environmental Sciences, Baylor University, Waco, TX, USA. 3Department of Chemistry, University of Michigan, Ann Arbor, MI, USA. 4Joint Institute for the Study of the Atmosphere and Ocean, University of Washington, Seattle, WA, USA. 5Pacific Marine Environmental Laboratories, National Oceanic and Atmospheric Administration, Seattle, WA, USA. Corresponding author: Rebecca Sheesley ([email protected]) *Now at Barrett Environmental, McKinney, TX, USA. †Now at Merck & Co., Inc., Kenilworth, NJ, USA. Key Points: Arctic MSA and non-sea-salt sulfate concentrations show increasing summer trends over the past two decades (3±4% and 2±14% respectively) at Utqiaġvik, AK. Concentrations of MSA at Oliktok Point are highly correlated to temperature as air masses are consistently from the Beaufort Sea. Summers with Arctic cyclones have better correlation of MSA with ambient temperature. This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1029/2020JD033225 ©2020 American Geophysical Union. All rights reserved.
    [Show full text]
  • Dimethyl Sulfate
    DIMETHYL SULFATE PRODUCT IDENTIFICATION CAS NO. 77-78-1 EINECS NO. 201-058-1 FORMULA (CH 3O) 2SO 2 MOL WT. 126.13 H.S. CODE 2920.90 TOXICITY Oral rat LD50: 205 mg/kg SYNONYMS Methyl Sulfate; Sulfuric acid dimethyl ester; Dimethyl Sulphate; Dimethylsulfaat (Dutch); Dimetilsolfato (Italian); Dms; Dwumetylowy Siarczan (Polish); Methyle (Sulfate De) (French); Sulfate De Dimethyle (French); Sulfate De Methyle (French); Sulfate Dimethylique (French); Sulfato De Dimetilo (Spanish); Dimethylester Kyseliny Sirove (Czech); Dimethylsulfat (Czech); DERIVATION CLASSIFICATION PHYSICAL AND CHEMICAL PROPERTIES PHYSICAL STATE Clear oily liquid MELTING POINT -32 C BOILING POINT 189 C SPECIFIC GRAVITY 1.333 SOLUBILITY IN WATER poor pH VAPOR DENSITY 4.3 AUTOIGNITION 495 C REFRACTIVE INDEX 1.3865 NFPA RATINGS Health: 4; Flammability: 2; Reactivity: 0 FLASH POINT 83 C STABILITY Stable under ordinary conditions APPLICATIONS Dimethyl Sulphate is used as a methylation agent in organic synthesis. It is also used as a solvent , stabilizer, sulfonation agent and catalyst. Its end applications include surfactants, pesticides, water treatment chemicals, dyes, flavors, pharmaceuticals, rubber chemicals and photographic chemicals. SALES SPECIFICATION APPEARANCE Clear oily liquid ASSAY 99.0% min ACIDITY (as H2SO4) 0.8% max TRANSPORTATION PACKING 260kgs in drum HAZARD CLASS 6.1 8 (Packing Group: I) UN NO. 1595 OTHER INFORMATION Hazard Symbols: T+ C, Risk Phrases: 25-26-34-43-45, Safety Phrases: 53-45 GENERAL DESCRIPTION OF ORGANOSULFUR COMPOUNDS Mercaptan: any of a class of organosulfur compounds is similar to the alcohol and phenol but containing a sulfur atom in place of the oxygen atom. Compounds containing -SH as the principal group directly attached to carbon are named 'thiols'.
    [Show full text]
  • The Influence of Ocean Acidification and Warming on DMSP & DMS in New Zealand Coastal Water
    atmosphere Article The Influence of Ocean Acidification and Warming on DMSP & DMS in New Zealand Coastal Water Alexia D. Saint-Macary 1,2,* , Neill Barr 1, Evelyn Armstrong 1,3 , Karl Safi 4, Andrew Marriner 1, Mark Gall 1, Kiri McComb 5, Peter W. Dillingham 6 and Cliff S. Law 1,2 1 National Institute of Water and Atmospheric Research, Wellington 6021, New Zealand; [email protected] (N.B.); [email protected] (E.A.); [email protected] (A.M.); [email protected] (M.G.); [email protected] (C.S.L.) 2 Department of Marine Science, University of Otago, Dunedin 9016, New Zealand 3 Department of Chemistry, University of Otago Centre for Oceanography, Dunedin 9016, New Zealand 4 National Institute of Water and Atmospheric Research, Hamilton 3216, New Zealand; karl.safi@niwa.co.nz 5 Department of Chemistry, University of Otago, Dunedin 9016, New Zealand; [email protected] 6 Department of Mathematics and Statistics, University of Otago, Dunedin 9016, New Zealand; [email protected] * Correspondence: [email protected] Abstract: The cycling of the trace gas dimethyl sulfide (DMS) and its precursor dimethylsulfonio- propionate (DMSP) may be affected by future ocean acidification and warming. DMSP and DMS concentrations were monitored over 20-days in four mesocosm experiments in which the temperature and pH of coastal water were manipulated to projected values for the year 2100 and 2150. This had no effect on DMSP in the two-initial nutrient-depleted experiments; however, in the two nutrient- amended experiments, warmer temperature combined with lower pH had a more significant effect Citation: Saint-Macary, A.D.; Barr, on DMSP & DMS concentrations than lower pH alone.
    [Show full text]
  • Dimethyl Sulfoxide (Dmso) 1133
    1321 DIMETHYLGLYCINE (DMG) PDR FOR NUTRITIONAL SUPPLEMENTS on cardiorespiratory function or lactate production." And Hoorn AJ. Dimethylglycine and chemically related amines male track athletes supplemented with DMG exhibited no tested for mutagenicity under potential nitrosation conditions. significant changes In short-term maximal treadmill Mutat Res. 1989; 222:343-350. performance. Moolenaar SH, Paggi-Bach J, Engelke UF, et al. Defect in On the other hand, an early fmding that DMG can enhance dimethylglycine dehydrogenase, a new inborn error of metabolism: NMR spectroscopy study. Clin Chern. 1999; both humoral and cell-mediated immune responses has been 45:459-464. fortified by some subsequent research. This animal research needs to be extended to humans. Reap EA, Lawson JW. Stimulation of the immune response by dimetbylglycine, a nontoxic metabolite. J Lab Clin Med. 1990; Early fears that DMG might be mutagenic now appear to be 115:481-486. unfounded. Rose RJ, Schlierf HA. Knight PK, et a!. Effects of N, N­ CONTRAINDICATIONS, PRECAUTIONS, ADVERSE IREACTIONS dimethylglycine on cardiorespiratory function and lactate CONTRAINDICATIONS performance in thoroughbred horses performing incremental Those with hypersensitivity to any component of the treadmill exercise. Vet Rec. 1989; 125; 268-271. preparation should not use DMG. PRECAUTIONS DMG is not advised for pregnant women or nursing mothers and should only be used in children under medical Dimethyl Sulfoxide supervision. (DMSO) ADVERSE REACTIONS Those with the rare disorder of dimethylglycine dehydroge­ TRADE NAMES nase deficiency may complain of a fish odor when taking Rimso-50 (Edwards Lifesciences) DMG supplements. No other significant adverse reactions have been reported with DMG. DESCRIPTION Dimethyl sulfoxide or DMSO is a very hygroscopic, sulfur­ INTERACTIONS containing organic compound.
    [Show full text]
  • Health Consultation
    Health Consultation POSSIBLE HEALTH IMPLICATIONS FROM EXPOSURE TO SULFUR GASES EMITTED FROM CHINESE-MANUFACTURED DRYWALL MAY 2, 2014 U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Agency for Toxic Substances and Disease Registry Division of Community Health Investigations Atlanta, Georgia 30333 Health Consultation: A Note of Explanation A health consultation is a verbal or written response from ATSDR or ATSDR’s Cooperative Agreement Partners to a specific request for information about health risks related to a specific site, a chemical release, or the presence of hazardous material. In order to prevent or mitigate exposures, a consultation may lead to specific actions, such as restricting use of or replacing water supplies; intensifying environmental sampling; restricting site access; or removing the contaminated material. In addition, consultations may recommend additional public health actions, such as conducting health surveillance activities to evaluate exposure or trends in adverse health outcomes; conducting biological indicators of exposure studies to assess exposure; and providing health education for health care providers and community members. This concludes the health consultation process for this site, unless additional information is obtained by ATSDR or ATSDR’s Cooperative Agreement Partner which, in the Agency’s opinion, indicates a need to revise or append the conclusions previously issued. You May Contact ATSDR Toll Free at 1-800-CDC-INFO or Visit our Home Page at: http://www.atsdr.cdc.gov HEALTH CONSULTATION POSSIBLE HEALTH
    [Show full text]
  • (MSAM), DMS and DMSO2 Measured in Air Over the Arabian Sea Achim Edtbauer1, Christof Stönner1, Eva Y
    A new marine biogenic emission: methane sulfonamide (MSAM), DMS and DMSO2 measured in air over the Arabian Sea Achim Edtbauer1, Christof Stönner1, Eva Y. Pfannerstill1, Matias Berasategui1, David Walter1,2, John N. Crowley1, Jos Lelieveld1,3, and Jonathan Williams1,3 1Atmospheric Chemistry Department, Max Planck Institute for Chemistry, Mainz, Germany 2Department Biogeochemical Processes, Max Planck Institute for Biogeochemistry, Jena, Germany 3Energy, Environment and Water Research Center, The Cyprus Institute, Nicosia, Cyprus Correspondence: Achim Edtbauer ([email protected]) Abstract. We present the first ambient measurements of a new marine emission methane sulfonamide (MSAM: CH5NO2S), along with dimethyl sulfide (DMS) and dimethyl sulfone (DMSO2) over the Arabian Sea. Two shipborne transects (W ! E, E ! W) were made during the AQABA (Air Quality and Climate Change in the Arabian Basin) measurement campaign. Molar mixing ratios in picomole of species per mole of air (throughout this manuscript abbreviated as ppt) of DMS were in the range 5 300–500 ppt during the first traverse of the Arabian Sea (first leg) and 100–300 ppt in the second leg. In the first leg DMSO2 was always below 40 ppt and MSAM was close to the limit of detection. During the second leg DMSO2 was between 40–120 ppt and MSAM was mostly in the range 20–50 ppt with maximum values of 60 ppt. An analysis of HYSPLIT back trajectories combined with calculations of the exposure of these trajectories to underlying chlorophyll in the surface water revealed that most MSAM originates from the Somalia upwelling region, known for its high biological activity. MSAM emissions can be as 10 high as one third of DMS emissions over the upwelling region.
    [Show full text]
  • MSM: the Mineral Essential for Health
    MSM: The Mineral Essential for Health Ron Hunninghake, MD & Anne Zauderer, DC Minerals are Essential • Vitamin deficiencies can be temporarily tolerated • Mineral deficiencies are poorly tolerated (and can be fatal) • Vitamins cannot function without minerals • In 1928, 3 minerals were recognized: iron, iodine, copper • Currently, 22 minerals are recognized as essential to health The Purpose of Minerals • Structure • Calcium, phosphorus, boron - for bones • Silicon - for collagen • Sulfur - for protein configuration and tissue structure • Function • catalysts and enzyme cofactors - to assist and speed biochemistry • muscle function, nerve impulse transmission • cell permeability and membrane receptor function Nutrient Cofactors Magnesium Zinc Zinc Magnesium Magnesium Zinc Magnesium Zinc Zinc Copper Magnesium Copper Copper Magnesium Magnesium Magnesium Sulfur: The 4th Most Plentiful Mineral • A pale yellow, brittle, bitter, nonmetallic mineral called sulfur • Referred to in Genesis as brimstone, associated with hell (volcanoes & hot springs) • A component of black gunpowder • Used in the vulcanization of rubber • Farmers use it as a fertilizer and a fungicide The Life Cycle of Sulfur • Algae converts inorganic sulfur to an organic molecule, dimethyl sulfide • Dimethyl sulfide is released to upper atmosphere, in the ozone layer • UV light catalyzes formation of DMSO (dimethyl sulfoxide) - then into MSM (methylsulfonylmethane) • MSM falls to earth, dissolved in rainwater Plant Roots Love MSM • MSM added to soil in 5 ppm water, concentrates in roots to 100 ppm in hours • Plants are natural reservoirs of MSM - animals eat the plants • Inorganic sulfur is captured by phytoplankton and algae into a volatile gas (DS) • DS --> DMSO --> MSM --> rain water --> root uptake --> food consumption Organic Minerals • Minerals are inorganic by nature • Minerals cannot be synthesized • Minerals bind to carbon molecules in plants and animals • Bound minerals are easier to absorb and utilize MSM Defined • A safe, natural, crystalline food substance originating in the ocean • Dr.
    [Show full text]